<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2WI46</accession>
    <name>M2WI46_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_57066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WI46"/>
    <dbReference type="HOGENOM" id="CLU_2250062_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="104" mass="11595" checksum="306DCFD68C05913C" modified="2013-05-01" version="1">MLGGPDLGEQVLGGRSLDSPEHAVDDCVTEFAAPQIVRKVLEVAGKWAFPMFHGHEIQLVGVDKVQEHFESIDFCFWKANNAVFCFWPSVRAGYLAERRFGIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJX5</accession>
    <name>M2WJX5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_28427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJX5"/>
    <dbReference type="HOGENOM" id="CLU_821417_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="338" mass="37857" checksum="C39C6ABFED46605E" modified="2013-05-01" version="1">MNSGKPAEDRASQIAALHGSLTQRAVISEPEPTDNSVGHTATMLDEAITAGVSRRIPLKQRVPNIADSVQRHQSAALQVPSQQLDPAQQGKVGQLLERRRDEVEQADVDELRQSAEQLYEEAERSVSQEYGDVKQSDKQRLDEIDRQIVEPCDESKLVQPCDRGKRRSMLKGVSLLRPTNDDESGTANNMTAENNASKKKERKRRAFANRLSSLMILSKAPAMTSGTLGSDYSNEHQTLKHRERRSLANVLLLRPPHLNEDEANDDKSTQSSSQLPEPDFGPPDLCSTLEKYIKDRLEVTTDREKQRFLMGYMNGLRRGGMITRFETKGKGKEKAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2WM90</accession>
    <name>M2WM90_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_25135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WM90"/>
    <dbReference type="STRING" id="675120.M2WM90"/>
    <dbReference type="eggNOG" id="KOG2382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_53_0_1"/>
    <dbReference type="OMA" id="FLGMSDN"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000039">
        <property type="entry name" value="Esterase ybfF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME43158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="267" mass="30268" checksum="749ED96581F9A724" modified="2013-05-01" version="1">MAYELWEPEEAQESQGVPIVFLHGLFGSKRNHRAISKALVRDLKRPIYAVDTRNHGDSSHDPRHDYEALAEDLELFIDTNKIEDGTLIGHSMGAKAVMTVALRKRVPIGNLILVDNAPVDAALKSDFGKYCVGMRKIEEAGVKSLRDADRILADYEESLPIRQFLLTNLMRAEDGTQKFKVPLKYLTDSLNKLGDFPFRDPDEARWEGPTLFVRGTRSQYIADDMLPVCGRFFPNFELADVDSGHWVISEKPDEFRQAVVDFLSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2WNM2</accession>
    <name>M2WNM2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WNM2"/>
    <dbReference type="STRING" id="675120.M2WNM2"/>
    <dbReference type="eggNOG" id="ENOG502R48A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1948776_0_0_1"/>
    <dbReference type="OrthoDB" id="4589723at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="129" mass="14994" checksum="33C39D7506AF637E" modified="2013-05-01" version="1">MSLHIRQQAIAEAEAEHSSSDAETHHSSDDEEDIPRPLRFSAECPLLPPSRSIDFPHIIQISDYDPAADLRDLTFPDIIATFLWHWDRVQFYKFFDMSRNHFELHYRAPRASGRDMVISRNGRGVMVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2XG50</accession>
    <name>M2XG50_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_39593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XG50"/>
    <dbReference type="HOGENOM" id="CLU_555506_0_0_1"/>
    <dbReference type="OrthoDB" id="10654660at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="491" mass="53281" checksum="D0A4951F63479D8D" modified="2013-05-01" version="1">MLSILPEVAAPVAQQMFGRKNCRHVSGTKAAAERIFSRRKVMQSTKHRWFQGAGHWYSQAGLEESTCAATMGVSLPSTMCYTYWTYRAMVAIDWNIAVSTVPSSDLLGSSIAALFQHPFTHMSLDCFPQSGHLLRDLVVVYEESRVSSNLRWSLLAGSVSAEPYCSVSTLLFFRGLSARTSHPVVGVDLDIRWTSPTGHVFVDASRWPFIIGTATNTSSSPEGSSSPSPKLLPKPFISGISLSGFMAAILLGDHICRLAFGITSSVADARSRGTHCGSDHRRPGQCENHVRMAAANMYGDFDACLDKLGLTKEQFHRSVAVQFEAMKKAIPETAPSWISVEVVGTNGATAVPSCTGSEAYTWQTPVKEKINVSDPSVMKGALARCMVREVQADPNPCLGIIEKSPYKPDVHTDVPTHEILAAKGGIETACDALVASYSLDETVESWQESRVTVDDPGLHTAVYVTTLSNLDTAPTFALNAELRDAIEVYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKN7</accession>
    <name>M2XKN7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_132404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKN7"/>
    <dbReference type="eggNOG" id="ENOG502QU9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029940_1_0_1"/>
    <dbReference type="OMA" id="WWEFSNI"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="29"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="324" mass="37159" checksum="B8747A53CEBA5203" modified="2013-05-01" version="1">MGKKRVLVSYGVDIDAVAGWLGSYGGEDSTLDISRGIWAGTIGTRRLLKLFDKHGIKATWFIPGHTLESFPEDCAAVRDAGHEIGLHGYSHENPADMTLEQQRDVLDKTYKLLTEFCGKPSRGSVAPWWETSREGTELMLSYGIEYDHSMSHEDCQMYWLRTGDSWTKIDYTKRAHEWMKPLIKGETTGLVEIPGSWYIDDLPPMMFIKNSANSHGWVNPRDVEAIWMDHFDYYYREFDDFVFPMTIHPDVSGRPHVLLMHERVIKHINKHEGVEWVTMEQMCDDFKSKSTPPPNAMMPASRAEVEAMLEQPKQADDTDYVFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2XZV3</accession>
    <name>M2XZV3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C4-dicarboxylate transporter/malic acid transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_75397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XZV3"/>
    <dbReference type="STRING" id="675120.M2XZV3"/>
    <dbReference type="eggNOG" id="ENOG502QV03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030057_2_0_1"/>
    <dbReference type="OMA" id="IFPCMIC"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME38619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="50397" checksum="212B10DB6118CDB8" modified="2013-05-01" version="1">MPNEQHLFWRRYLPSTNPSRTTSAVPSRAGSQLDLSDAEKLKHLGGINGRLPQHDDPSHQVPLRERIKHFTWAWFTLPMSTGGLALLLHDTPNRFPGLETIGKVVYIFDLVIFFCLCAMMATRFIMNPGVLKKSLMHPTESLFFATVFLALVNVIGGMQIYGGPTTGDWLVVVVRVLFWMYVASTFITAVLQYMVLFSAERLTIQSMTPGWIFPIFPIMLSGTLASIIAVDQPVVQREAIIFAGITFQGLGWMVASMVYAIYMHRLMQFGLPAPNLRPGMFIAVGPPAFTGLALIGLGSALQEDMAYFKARSGMIMVLQTMANFIAIFLWSLSFWFFCIATLSVLRGVKNMRFHLTWWAFVFPNIGFTIATIRIGEQLESEGILWVASIMTVLLVAMWIFVFVAHVRAVMLRQIMMPGVDEDKEDYKANDRKNNIPVPPDHQRTTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y0K0</accession>
    <name>M2Y0K0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_139785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y0K0"/>
    <dbReference type="HOGENOM" id="CLU_3129712_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="50" mass="5986" checksum="6CE3589C353283A9" modified="2013-05-01" version="1" fragment="single">RYYNKKHKPKSYYIGEIVLLSTKNLKLAILKKKIGSKFIRPYYIIDAIRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-02-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y151</accession>
    <name>VBSA_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Versicolorin B synthase</fullName>
            <ecNumber evidence="2">4.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-oxoaverantin cyclase</fullName>
            <ecNumber evidence="2">4.2.1.142</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dothistromin biosynthesis protein vbsA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">vbsA</name>
        <name type="ORF">DOTSEDRAFT_75656</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Appl. Environ. Microbiol." volume="68" first="2885" last="2892">
            <title>Dothistroma pini, a forest pathogen, contains homologs of aflatoxin biosynthetic pathway genes.</title>
            <authorList>
                <person name="Bradshaw R.E."/>
                <person name="Bhatnagar D."/>
                <person name="Ganley R.J."/>
                <person name="Gillman C.J."/>
                <person name="Monahan B.J."/>
                <person name="Seconi J.M."/>
            </authorList>
            <dbReference type="PubMed" id="12039746"/>
            <dbReference type="DOI" id="10.1128/AEM.68.6.2885-2892.2002"/>
        </citation>
        <scope>FUNCTION</scope>
        <source>
            <strain>ATCC MYA-605</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Mycopathologia" volume="161" first="283" last="294">
            <title>A polyketide synthase gene required for biosynthesis of the aflatoxin-like toxin, dothistromin.</title>
            <authorList>
                <person name="Bradshaw R.E."/>
                <person name="Jin H."/>
                <person name="Morgan B.S."/>
                <person name="Schwelm A."/>
                <person name="Teddy O.R."/>
                <person name="Young C.A."/>
                <person name="Zhang S."/>
            </authorList>
            <dbReference type="PubMed" id="16649078"/>
            <dbReference type="DOI" id="10.1007/s11046-006-0240-5"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Fungal Genet. Biol." volume="44" first="1342" last="1354">
            <title>A fragmented aflatoxin-like gene cluster in the forest pathogen Dothistroma septosporum.</title>
            <authorList>
                <person name="Zhang S."/>
                <person name="Schwelm A."/>
                <person name="Jin H."/>
                <person name="Collins L.J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="17683963"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2007.06.005"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC MYA-605</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="Mycol. Res." volume="112" first="138" last="146">
            <title>Early expression of aflatoxin-like dothistromin genes in the forest pathogen Dothistroma septosporum.</title>
            <authorList>
                <person name="Schwelm A."/>
                <person name="Barron N.J."/>
                <person name="Zhang S."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="18262779"/>
            <dbReference type="DOI" id="10.1016/j.mycres.2007.03.018"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2009" name="Toxins" volume="1" first="173" last="187">
            <title>Functional analysis of a putative dothistromin toxin MFS transporter gene.</title>
            <authorList>
                <person name="Bradshaw R.E."/>
                <person name="Feng Z."/>
                <person name="Schwelm A."/>
                <person name="Yang Y."/>
                <person name="Zhang S."/>
            </authorList>
            <dbReference type="PubMed" id="22069539"/>
            <dbReference type="DOI" id="10.3390/toxins1020173"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2010" name="Toxins" volume="2" first="2680" last="2698">
            <title>Genetics of dothistromin biosynthesis of Dothistroma septosporum: an update.</title>
            <authorList>
                <person name="Schwelm A."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="22069571"/>
            <dbReference type="DOI" id="10.3390/toxins2112680"/>
        </citation>
        <scope>REVIEW ON FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2013" name="Fungal Genet. Biol." volume="51" first="12" last="20">
            <title>Dothistromin genes at multiple separate loci are regulated by AflR.</title>
            <authorList>
                <person name="Chettri P."/>
                <person name="Ehrlich K.C."/>
                <person name="Cary J.W."/>
                <person name="Collemare J."/>
                <person name="Cox M.P."/>
                <person name="Griffiths S.A."/>
                <person name="Olson M.A."/>
                <person name="de Wit P.J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23207690"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.11.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2013" name="New Phytol." volume="198" first="525" last="535">
            <title>Fragmentation of an aflatoxin-like gene cluster in a forest pathogen.</title>
            <authorList>
                <person name="Bradshaw R.E."/>
                <person name="Slot J.C."/>
                <person name="Moore G.G."/>
                <person name="Chettri P."/>
                <person name="de Wit P.J."/>
                <person name="Ehrlich K.C."/>
                <person name="Ganley A.R."/>
                <person name="Olson M.A."/>
                <person name="Rokas A."/>
                <person name="Carbone I."/>
                <person name="Cox M.P."/>
            </authorList>
            <dbReference type="PubMed" id="23448391"/>
            <dbReference type="DOI" id="10.1111/nph.12161"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2015" name="Fungal Biol." volume="119" first="503" last="508">
            <title>Regulation of the aflatoxin-like toxin dothistromin by AflJ.</title>
            <authorList>
                <person name="Chettri P."/>
                <person name="Ehrlich K.C."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="25986547"/>
            <dbReference type="DOI" id="10.1016/j.funbio.2015.01.007"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 5 6 12 14 15 16">Versicolorin B synthase; part of the fragmented gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B (PubMed:12039746, PubMed:17683963, PubMed:22069571, PubMed:23207690, PubMed:23448391). The first step of the pathway is the conversion of acetate to norsolorinic acid (NOR) and requires the fatty acid synthase subunits hexA and hexB, as well as the polyketide synthase pksA (PubMed:16649078, PubMed:23207690). PksA combines a hexanoyl starter unit and 7 malonyl-CoA extender units to synthesize the precursor NOR (By similarity). The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by the fungal fatty acid synthase hexA/hexB (By similarity). The second step is the conversion of NOR to averantin (AVN) and requires the norsolorinic acid ketoreductase nor1, which catalyzes the dehydration of norsolorinic acid to form (1'S)-averantin (PubMed:23207690). The cytochrome P450 monooxygenase avnA then catalyzes the hydroxylation of AVN to 5'hydroxyaverantin (HAVN) (PubMed:23207690). The next step is performed by adhA that transforms HAVN to averufin (AVF) (PubMed:23207690). Averufin might then be converted to hydroxyversicolorone by cypX and avfA (PubMed:23207690). Hydroxyversicolorone is further converted versiconal hemiacetal acetate (VHA) by moxY (PubMed:23207690). VHA is then the substrate for the versiconal hemiacetal acetate esterase est1 to yield versiconal (VAL) (PubMed:23207690). Versicolorin B synthase vbsA then converts VAL to versicolorin B (VERB) by closing the bisfuran ring (PubMed:16649078, PubMed:23207690). Then, the activity of the versicolorin B desaturase verB leads to versicolorin A (VERA) (PubMed:23207690). DotB, a predicted chloroperoxidase, may perform epoxidation of the A-ring of VERA (PubMed:23207690). Alternatively, a cytochrome P450, such as cypX or avnA could catalyze this step (PubMed:23207690). It is also possible that another, uncharacterized, cytochrome P450 enzyme is responsible for this step (PubMed:23207690). Opening of the epoxide could potentially be achieved by the epoxide hydrolase epoA (PubMed:23207690). However, epoA does not seem to be required for DOTH biosynthesis, but other epoxide hydrolases may have the ability to complement this hydrolysis (PubMed:23207690). Alternatively, opening of the epoxide ring could be achieved non-enzymatically (PubMed:23207690). The next step is the deoxygenation of ring A to yield the 5,8-dihydroxyanthraquinone which is most likely catalyzed by the NADPH dehydrogenase encoded by ver1 (PubMed:23207690). The last stages of DOTH biosynthesis are proposed to involve hydroxylation of the bisfuran (PubMed:23207690). OrdB and norB might have oxidative roles here (PubMed:23207690). An alternative possibility is that cytochrome P450 monoogenases such as avnA and cypX might perform these steps in addition to previously proposed steps (PubMed:23207690).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2S-3S)-versiconal hemiacetal = versicolorin B + H2O</text>
            <dbReference type="Rhea" id="RHEA:33859"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:77950"/>
            <dbReference type="ChEBI" id="CHEBI:77951"/>
            <dbReference type="EC" id="4.2.1.143"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-5'-oxoaverantin + H(+) = (1'S,5'S)-averufin + H2O</text>
            <dbReference type="Rhea" id="RHEA:35671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71537"/>
            <dbReference type="ChEBI" id="CHEBI:77933"/>
            <dbReference type="EC" id="4.2.1.142"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="7 8 9 10">Expression is positively regulated by the dothistromin-specific transcription factors aflR and aflJ (PubMed:23207690, PubMed:25986547). Dothistromin biosynthetic proteins are co-regulated, showing a high level of expression at ealy exponential phase with a subsequent decline in older cultures (PubMed:17683963, PubMed:18262779).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="7">Impairs the production of dothistromin (PubMed:18262779).</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.143" evidence="2"/>
    <dbReference type="EC" id="4.2.1.142" evidence="2"/>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y151"/>
    <dbReference type="SMR" id="M2Y151"/>
    <dbReference type="STRING" id="675120.M2Y151"/>
    <dbReference type="GlyCosmos" id="M2Y151">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EME39034">
        <property type="protein sequence ID" value="EME39034"/>
        <property type="gene ID" value="DOTSEDRAFT_75656"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="OMA" id="REMFYMQ"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046572">
        <property type="term" value="F:versicolorin B synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004029179" description="Versicolorin B synthase">
        <location>
            <begin position="27"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="106"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="172"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="617"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="628"/>
            <end position="629"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="E4QP00"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q12062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="12039746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="16649078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="17683963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="18262779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="23207690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="25986547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="11">
        <source>
            <dbReference type="PubMed" id="17683963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="12">
        <source>
            <dbReference type="PubMed" id="22069571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="13"/>
    <evidence type="ECO:0000305" key="14">
        <source>
            <dbReference type="PubMed" id="17683963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="15">
        <source>
            <dbReference type="PubMed" id="23207690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="16">
        <source>
            <dbReference type="PubMed" id="23448391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME39034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="647" mass="70966" checksum="F4A8C18293AC9368" modified="2013-05-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y2B1</accession>
    <name>M2Y2B1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_38631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y2B1"/>
    <dbReference type="STRING" id="675120.M2Y2B1"/>
    <dbReference type="ESTHER" id="mycp1-m2y2b1">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_5_1"/>
    <dbReference type="OMA" id="FTCNTNY"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="98"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="604" mass="64963" checksum="052CAE7A968AE99E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y2K2</accession>
    <name>M2Y2K2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_56878</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y2K2"/>
    <dbReference type="STRING" id="675120.M2Y2K2"/>
    <dbReference type="eggNOG" id="KOG3165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081098_0_1_1"/>
    <dbReference type="OMA" id="GMMDCLL"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000019">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004029904" description="PIN domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="95"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME39524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="223" mass="25136" checksum="7701287F1A6B5747" modified="2013-05-01" version="1">MGSIIGHIAISLTLSLSISALKDIGFGMGVAKKVRKFATVKRVIGQRDARLKKNVLKESSEDKRKKTNDGELVREIPQVPSNMFFQANTALQAPYSVLVDTNFLSHTVHHKLPLLPTLMDTLYATCTPIITSCVMAELEKLGPKYRIALQIARDERWERLPCDHKGTYADDCIVDRVMKQRVYLVATNDRDLKRRIRKIPGVPIISVARGKYVIERLPDAPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y404</accession>
    <name>M2Y404_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Catalase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_63323</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y404"/>
    <dbReference type="STRING" id="675120.M2Y404"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_1"/>
    <dbReference type="OMA" id="YVKIHFK"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF26">
        <property type="entry name" value="CATALASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="12">
        <location>
            <begin position="16"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME43024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="513" mass="57508" checksum="8B647B1991248F94" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y4C2</accession>
    <name>M2Y4C2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_72496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y4C2"/>
    <dbReference type="STRING" id="675120.M2Y4C2"/>
    <dbReference type="eggNOG" id="ENOG502QSZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023536_1_0_1"/>
    <dbReference type="OrthoDB" id="349045at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHIM1" evidence="4">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="523"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME43139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="567" mass="62599" checksum="BD37BD06FCE90747" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y4G7</accession>
    <name>M2Y4G7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_35500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y4G7"/>
    <dbReference type="HOGENOM" id="CLU_2073093_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="118" mass="13297" checksum="798AD27EB96614BC" modified="2013-05-01" version="1">MPATSPTDSHYYSLQHCSDGPWRIETIEAEPHKHITLGVIQDAVLRARLPHRTNCSKPKKRSEATVVIDCRTGVLAQDDPLMVQRKEKTKRWKVNGGVPSNWDYDNVSEDLSSSGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2YHY0</accession>
    <name>M2YHY0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_29724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YHY0"/>
    <dbReference type="HOGENOM" id="CLU_683390_0_0_1"/>
    <dbReference type="OrthoDB" id="10682643at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="403" mass="44011" checksum="14D55350FF0500C4" modified="2013-05-01" version="1">MNTTASNISVETHSQHSSASRWASKALIGLITPNTQFLTGQIRMQNPPDPSNNSTDQMAHAKRPDDYRPVSPDFTSSNVPTPFRLDVYTPPMDDGYRPVSPEFTVIHPAQATFEPNNRYAPPSFSMAHQSQVSPRVAEPLTIQHHYFPTNKSIDRNNATAVTVASTTSRKRNATPSMTEVSTPASVTRHQQNASAPEAFPTSLPYQSSLTTVLSSFGAQQAPGGTNVGSFDDTAQPLRLPQEDSRPVNSTRKERHRGSDNLSTLPRNIRQREVIQCERCGSQVNRGSLLRHQTKSKCARLVRHPQVFPTPETYTSEINVSESASPDEFITPKFTPINAGTTLSESATIFHIHANGAVSSGTTSIGIPEAGRFRVVQGSSDLSEIARFRTLEALPEEPQAVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJL2</accession>
    <name>M2YJL2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_179527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJL2"/>
    <dbReference type="eggNOG" id="ENOG502S0HZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092498_2_0_1"/>
    <dbReference type="OMA" id="ICINSYD"/>
    <dbReference type="OrthoDB" id="3641883at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17615">
        <property type="entry name" value="C166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="178" mass="18832" checksum="4B677CFDE4A53AE6" modified="2013-05-01" version="1">MKAGHCDLQDTAGITKLKAPEIVDELNGLTSKAQALQAPIQSITPNNGVLIVVSQGPFPSIIKGYADIVTAGTYLVAGLQDQGSLSGKDADDVYSAYTAFAKVNEFTLHMLNGKGATYANLPFVTQPVAAVLRNVENIYDTLAFTLADATKSHAAELQGAAGKLGEELDRIIYTYQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>M2YL40</accession>
    <name>M2YL40_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_91884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.M2YL40"/>
    <dbReference type="eggNOG" id="KOG0902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000893_1_0_1"/>
    <dbReference type="OMA" id="MKANFFV"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140504">
        <property type="term" value="P:microlipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000022">
        <property type="entry name" value="Phosphatidylinositol 4-kinase stt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="1351"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="1611"/>
            <end position="1904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME39585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1920" mass="214375" checksum="56757A578A117290" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2YL54</accession>
    <name>M2YL54_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_75300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YL54"/>
    <dbReference type="STRING" id="675120.M2YL54"/>
    <dbReference type="eggNOG" id="KOG2316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010289_2_0_1"/>
    <dbReference type="OMA" id="HCRLAQS"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME39600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="636" mass="69131" checksum="8CF6B5131380A4EC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLP7</accession>
    <name>M2YLP7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_72384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLP7"/>
    <dbReference type="eggNOG" id="ENOG502SAIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021051_1_1_1"/>
    <dbReference type="OMA" id="WHQTFRF"/>
    <dbReference type="OrthoDB" id="2796277at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="358"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME42926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="548" mass="61463" checksum="391508D034DA2F9F" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2YMY6</accession>
    <name>M2YMY6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_63557</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YMY6"/>
    <dbReference type="STRING" id="675120.M2YMY6"/>
    <dbReference type="eggNOG" id="ENOG502S8GR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_3_1"/>
    <dbReference type="OMA" id="GGYKGSW"/>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="12">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME43305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="122" mass="13657" checksum="C9B14C7D93D4CFD6" modified="2013-05-01" version="1">MDVQLRRINESGITAFRKQTLSLLCKIPRGRYSTYGAMSDWISKNSHKTCARAVGNAMRNNPFAPEVPCHRILAGDGTLGGFKGSWGEQGKYAKHKHELLHAEGVRFDTKGHVKGPLFRDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBX5</accession>
    <name>N1PBX5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_91218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBX5"/>
    <dbReference type="STRING" id="675120.N1PBX5"/>
    <dbReference type="eggNOG" id="ENOG502SQTP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036220_0_0_1"/>
    <dbReference type="OMA" id="ISTWRCT"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42354">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42354:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="615" mass="68833" checksum="260085D9A0D38B89" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCM1</accession>
    <name>N1PCM1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_178949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCM1"/>
    <dbReference type="STRING" id="675120.N1PCM1"/>
    <dbReference type="eggNOG" id="KOG0679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_6_2_1"/>
    <dbReference type="OMA" id="MTEAPWN"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="476" mass="52091" checksum="CBCC3FFA253F58FC" modified="2013-06-26" version="1">MASTLPPTQPPANQEYAGDEINALILDPGSHSTRAGFAGEDTPKSVVPSSYAAHDGSNLFGENAIHLYQPGLEIRNPYNSDGIVEDWDTALRLWEYSVTSRLTGSRQTPPSRNGLNNLSEQEKKDAQGDTAMDLDEQAEEMDEQEKVLGEYPLLMSEPAWNPQKAREKTMEIAIEEWGVPAFFLAKNGQLAAYSQGKATALVIDIGHLNTSITALWEGMALKKGCVHTPLGGSWINEQLRLMFSSMNAPLTPHFMVKSKQPVDAGAPSNATYAQFSKAPTDSFRRLEEERVLTAFKESVVQAWGGPSRLENSSQGGTSNADYVRSLPPKPFEMPDGWNQIFGIERFKVAEGLFDSNAAYTDASHPALNGDQTIVSAAKNAINACDVDTRPHLMNNIILTGAGSLIAGLPERIQSDLQALFPNPKIRVIANSNSVERKYGGWIGGSVLGSLGTFHQMWISRQEYEEFGAQIMEKRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD95</accession>
    <name>N1PD95_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_74951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD95"/>
    <dbReference type="STRING" id="675120.N1PD95"/>
    <dbReference type="eggNOG" id="ENOG502QW3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012543_1_0_1"/>
    <dbReference type="OMA" id="WAGCFGE"/>
    <dbReference type="OrthoDB" id="4005299at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109720" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="58"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="291"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME40317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="67500" checksum="A87F69226BD85F7D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEB0</accession>
    <name>N1PEB0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_27300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEB0"/>
    <dbReference type="HOGENOM" id="CLU_3032316_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="55" mass="6165" checksum="2320166F511A7DD6" modified="2013-06-26" version="1">MGLHVICGALSGKPSNGDRVTNREGLVKLLIERLGTKTNDEWTETLEGIRLPYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEC5</accession>
    <name>N1PEC5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_37697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEC5"/>
    <dbReference type="HOGENOM" id="CLU_1165792_0_0_1"/>
    <dbReference type="OMA" id="MCRANME"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="27159" checksum="5A4D384E7BDEDAA2" modified="2013-06-26" version="1">MCRANMENKARNEMQPKAEYSRALDRVAAQREARLVVHIEIYDDDEQLRYHTVDRAALEALSPLLAYPAVQGRGHPVLDLTDESYDTFKLLNHFILKGHLPQAPADDIDGIRHYEEHLISGWCFGRRYRAPKLQNAAMHGLLGLLRSQVDLIFYTQYTVRHVSIQSALGGLLLEKLVFASRKVGLEVEIQGWECHNSLPSSRDFLEALGRAFAEHERAPLKWDGEVEDEVRADCVVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PED0</accession>
    <name>N1PED0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_37299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PED0"/>
    <dbReference type="HOGENOM" id="CLU_1865082_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="137" mass="14874" checksum="6F8C4C1649A57941" modified="2013-06-26" version="1">MPPPQPEPTLLSLTSFPLSLPSSPEARYSQQPSPSPSPSPSPATTTTTPSSSSSSSPIIKHTTKPHPYTFSQSHSKVPPTPPHRKTKTSPRNQMFEELIQSGWEISAPGGSEDETSGLRGMYYDLEIEEDLGENLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEI2</accession>
    <name>N1PEI2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_27166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEI2"/>
    <dbReference type="HOGENOM" id="CLU_2399661_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="93" mass="10647" checksum="BC84EFA49B24C34D" modified="2013-06-26" version="1">MWTEDGEDQWLRSRPLHEVQDQLWLAVSSFPSEDFARGQHSSSYRLQVLLEQLEGLVPPPTHIKRFPEHQTEPTQLVKILLQLNTGDLDTGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEN3</accession>
    <name>N1PEN3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_27980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEN3"/>
    <dbReference type="HOGENOM" id="CLU_1004814_0_0_1"/>
    <dbReference type="OrthoDB" id="10599911at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109772" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="29126" checksum="C2AB63C934B84CC7" modified="2013-06-26" version="1">MKLTTFAAGAALAVTGAVAQATPSAGGINCKITPVGGDKDHYTVYIGEPDSTCGAVALSLSQLKHVHEYTCAAHLTNVSTQVYAADSSEHEAVVEALQRAYPGLEFYQKGACRKNTTKREETGVNAGRATRGITKRAAPGQAVYNVCDITSVAGQNNGKTTLLLNVDIGLPFNGGSGCNYIHDRIGSIGDWSCTDDGSGDTSLKFTTERNGKLVPVRDATVNDIFHAYGGAITSQNVGGIHDHGYCTATYPSKRRATRNVAAAGRIQSQLTKRVESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEQ3</accession>
    <name>N1PEQ3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_108411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEQ3"/>
    <dbReference type="STRING" id="675120.N1PEQ3"/>
    <dbReference type="eggNOG" id="ENOG502SC9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1791445_0_0_1"/>
    <dbReference type="OMA" id="YWRAKEQ"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16172" checksum="85D37FFC62556B38" modified="2013-06-26" version="1" fragment="single">DPLSTSAATKTEDILGGRAAESEIGATDGALGSGWEGDEEAEARKITETQIKRYWRAKEQERKAPRVHQEDLSVHEKVLREWDMSGQYGPCIGIARLKRWKRANTLGLKPPMEVLSVLLKDMDGGNAKSHRAHVDELMSSRFVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF45</accession>
    <name>N1PF45_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ribonuclease T2-like</fullName>
            <ecNumber evidence="4">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DOTSEDRAFT_74867</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="4"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF45"/>
    <dbReference type="eggNOG" id="KOG1642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037966_0_1_1"/>
    <dbReference type="OMA" id="YMSEYWK"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000004">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="19">
        <location>
            <begin position="323"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EME40190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="439" mass="46544" checksum="B86033763989C51E" modified="2013-06-26" version="1">MAWFDGVQDAPARHLENFLASKPDIFDNMPSPRAISGFALSALGTAQQVLGSLSSPVSRRADLGESKTCSGGQLSCHNTTVQTDLCCFNSPGGALLQTQFWDTSPQTGPVNSWTIHGLWPDRCDGTYDANCDDQRAYTNITAILNSFGKQDLVSYMNTYWPDYQGNNEQFWEHEWGKHGTCVSTLDPDCYTNYLPTEEVPDFFQKTVDLFKTLPSYTWLSDAGITPSTSQTYTLSQIEDALAKQHGGNKPYVGCASGAMDELWYFYNVQGSVQKGTFESAASLTKSNCPSSGIKYLPKSSNGGSPSTTSTAPGSSPTSSPGGSFSGSGYLNVVSGGSQNGCIISAGTWYTSGTCATFTATASGDGFNLKSSKGNCGVVSGVLTCGSGITSAVFTGDGNTLEYSDSTAFSTDSTPSGSTQAKVYPGSSKPTEFTITWQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF90</accession>
    <name>N1PF90_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_136755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF90"/>
    <dbReference type="STRING" id="675120.N1PF90"/>
    <dbReference type="eggNOG" id="KOG2565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_0_2_1"/>
    <dbReference type="OMA" id="WPDSFWR"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME41047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="402" mass="45439" checksum="479D788023B42A62" modified="2013-06-26" version="1">MSEVKKYSVNVPQAKIDRLKRRLEDTDFPNELEDAGWDYGSPLTDIKRFVEYWKTEFDWRAHEKKLNELPNYEVQVNVDKHGPVDMHFIHQKCSNPNAIPLLFVHGWPGSFLEVTKILPLLANTSNDSTKPSFHIVAPSLPNYGFSGPALKRGFNIARCAEACHKVMLALGYDQYVTQGGDTGFLITRAMAHLYPQHVKACHVNWAWAAKPEEYANGAKPEPEYSEREKKHLAMAERWWAGEGRGYLAIQSTRPATINFALRDSPVGLLAWIWDKMVEWSDDYPWTEDEVCLWVSLYVFSRAGPDATTYLYYEILHDASEITLPTVQGYIDVPLGIADFPVEICNSPVSWRESMGPIVFQKIYEKGGHFAGWERPSDIADGLCEMFGKNGGAHGVVAGKSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF96</accession>
    <name>N1PF96_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_27636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF96"/>
    <dbReference type="HOGENOM" id="CLU_737751_0_0_1"/>
    <dbReference type="OrthoDB" id="10680668at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="375" mass="42477" checksum="D075F1EDA92712C0" modified="2013-06-26" version="1">MDASDRSNLRVSTLEIGEVNKWALSMWEFDGIIVNVSRHSRSLNCTVHVEPNAPEHDASCDLLEEGVGKNVKRLTGFQDITVDEKLEESWHEMSEDIYDPQEAQAVVSEHRKRQRQKAADKTRKVQRDTGMRAERTAKKAENEDTKRTGRRCNYEDNLAKDAAALLRGKGRPPNNLLVICEPMPAVESYNAQPTSFEKHQAHGWHEVKPGAWAENPSHIPGDIIKILDKSEAPEFRRHRHMPKPEKVKKLKDVLDIEARCHKQLLSGDRLAGSVPVTEQKRMANNMNAKMLRLEKAHHIEADRIMHHALHGHTRGFSPLAVEDLMANITEAEHAQDGFVEWRLKALNSDVSEMYLVGDGSEIEPRPIEMGSCLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGX3</accession>
    <name>N1PGX3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_81873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGX3"/>
    <dbReference type="STRING" id="675120.N1PGX3"/>
    <dbReference type="eggNOG" id="KOG0151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007957_0_0_1"/>
    <dbReference type="OMA" id="VWYRWKL"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="3">
        <location>
            <begin position="477"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="685"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME41617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="823" mass="90411" checksum="8879553E04158895" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHG1</accession>
    <name>N1PHG1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sexual development protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHG1"/>
    <dbReference type="eggNOG" id="ENOG502SM3U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045147_0_0_1"/>
    <dbReference type="OMA" id="IKPCEYK"/>
    <dbReference type="OrthoDB" id="5293813at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109104" description="Sexual development protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="38792" checksum="05F934234C418582" modified="2013-06-26" version="1">MHSKLIVSALLGSAAASAIPNQASKDSYSNPAPPTGANGKNQPFKFPLSNGFPNIQVPSDALTTIQKQAHGTLPNGALPKKLNDTSATVLQLIAFNEIFEVAYFTSLLGNITDGTYNVGQGAAKDIVVNAITAVQAQEELHALGANAILSSAGRTPIKPCEYKFPVSDFDSSIALASTFTDLVLGTLQDALAAFGTDGDSELLALIGAVIGQEGEQDGFYRNIGKKIPSALPFLTRSTGPFAFSALNQMFVVPGSCPNANIIGLPIFEPLTVVTPPTAPKDQTVTFSITSSKAIDLTKYSVVYINQQNVPVSEPIHSVAQKGDVYTFCADFPGAKNLMDGLTIAGLALGAGPFADVTAATAATKYGPGLIEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI49</accession>
    <name>N1PI49_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DOTSEDRAFT_74012</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PI49"/>
    <dbReference type="STRING" id="675120.N1PI49"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="OMA" id="RIWFRPK"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="114"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EME41804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="510" mass="57124" checksum="02A4B1F59C4CEA65" modified="2013-06-26" version="1">MNHEGSKQDPATKLTGEEIAKHNDRESCWVIVHGKAYDVTEFLPEHPGGPKVILKYAGKDATEEYEPIHPPDTLDKFLDKSKHLGEVDMGTVEQEEKKYDPEEEERQERIKHMPILEQCYNLMDFEAVARRVMKKTAWAYYSSGADDEITMRENHSAFHKIWFRPRILQNVEHIDLSTTMLGTKCSIPFYVTATALGKLGNPEGEVVLTRGAKKHNVIQMIPTLASCSFDEIVDAKEGDQVQWLQLYVNKDREITKRIVEHAEKRGCKGLFITVDAPQLGRREKDMRSKFDDTGSNVQNTGGDNVDRSQGAARAISSFIDPALEWKDIPWFLSITKMPIILKGVQRVEDVIQAIAAGVHGVVLSNHGGRQLDTARSGVEILAEVMPELRRLGLDKKIEIFIDGGIRRATDIIKALCLGATGVGIGRPFLFAMSAYGLPGVDRAMQLLKDEMEMNMRLIGCNDVSQLGPEFVDTRALSMHTTGVPSDVRSLDSYDPMLGPRSPVWEQKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIR5</accession>
    <name>N1PIR5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_175617</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIR5"/>
    <dbReference type="STRING" id="675120.N1PIR5"/>
    <dbReference type="eggNOG" id="KOG0478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_1_1"/>
    <dbReference type="OMA" id="AFFKCNV"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="635"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="358"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="896"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME42503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1056" mass="115500" checksum="D4BDEB1CF5438D16" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIZ0</accession>
    <name>N1PIZ0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_134157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIZ0"/>
    <dbReference type="STRING" id="675120.N1PIZ0"/>
    <dbReference type="eggNOG" id="KOG1142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_921416_0_0_1"/>
    <dbReference type="OMA" id="HATNQPW"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000037">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="184"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME42558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="302" mass="33244" checksum="943EF0D0C2FA8411" modified="2013-06-26" version="1">MLQQQQLLQQQQLQHPTQARAAVQLKPAGQPGQQPNLQQQQQQMQQMQQQQAHMQTPTQAGQQQQQGTPASAVPNNVGQPAPQRPQALTHNQAVSQAADAARQQTQAQQNTPTGGYPNLQPQQGNSSNTKFPIPKTLALDPRSQQAVAGPPSRPTMATPGMMYQPGIQRPPPYTLEGEGDRVLSKRKLDELVRQVTGAAPPSINESESSSVLAPEVEESILQVADNFVDDVITSACRLAKLRSNQTLDIRDIQMVLERNYGIRIPGYSLDETRIVRKFQPTPGWHSKMQAVQAGKVMNNRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ71</accession>
    <name>N1PJ71_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_73874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ71"/>
    <dbReference type="STRING" id="675120.N1PJ71"/>
    <dbReference type="eggNOG" id="KOG1755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120772_1_1_1"/>
    <dbReference type="OMA" id="QGQKFML"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000755">
        <property type="term" value="P:cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000001">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME41595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="130" mass="13913" checksum="C7893417DD228619" modified="2013-06-26" version="1">MSWQAYVDQSLVGTGNVDKAAIFSAAGDSVWATSSGFQVSPQEMKEIVTAYKDTADVKQVQSTGLHIAGEKFVVLKADDRSIYGKKGREGVVIVKTTQAILVAHYPESVQPGSAANTVEQLGDYLIKVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJG1</accession>
    <name>N1PJG1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_54670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJG1"/>
    <dbReference type="STRING" id="675120.N1PJG1"/>
    <dbReference type="HOGENOM" id="CLU_794586_0_0_1"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="2">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="349" mass="38933" checksum="97515EA4317AFCE1" modified="2013-06-26" version="1">MPVDEKFCFNTSLRRVEYSRRERLILTFGSYSPYNLTPPPLYQVSRQVRAESLPIFYGYYNFITLHPRRVVDLLRARYDGDAPVDPFLGFDYSPAGGEAGATHRAAGGHLATYNGERNHFARTERTHTMESGFVRISNMADPEPPPAPVPFPIKIVTEPPPADDSPGGLDLPPAGKGNDQVYSAWGRSLAREPKRATKTYRATHEIEAEKEAVKQSPGDGLQIQENAAKSFEEAATDCKTKLAAVVEEITNGDCWFLPALMAGFTKKELTDRLCVARNEQVDWDVDKKEGQGVRHDSDKLKASLQKGGTTGGHAYAVLEAWEESDLKLLKLKNPWGEVEREGTELRMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJQ0</accession>
    <name>N1PJQ0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1765-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJQ0"/>
    <dbReference type="STRING" id="675120.N1PJQ0"/>
    <dbReference type="eggNOG" id="ENOG502QWKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003877_1_1_1"/>
    <dbReference type="OMA" id="KTCAYAF"/>
    <dbReference type="OrthoDB" id="296767at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013887">
        <property type="entry name" value="UPF0592"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988:SF1">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08578">
        <property type="entry name" value="DUF1765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1180" mass="131660" checksum="17613785A508FBEB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJR0</accession>
    <name>N1PJR0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_71554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJR0"/>
    <dbReference type="STRING" id="675120.N1PJR0"/>
    <dbReference type="eggNOG" id="ENOG502S5V9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017004_1_0_1"/>
    <dbReference type="OMA" id="MILICHF"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME43737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="657" mass="73486" checksum="3ED25A5484490243" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKA7</accession>
    <name>N1PKA7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_71678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKA7"/>
    <dbReference type="STRING" id="675120.N1PKA7"/>
    <dbReference type="eggNOG" id="ENOG502QPR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024588_2_0_1"/>
    <dbReference type="OMA" id="GWVEGWQ"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF20">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="46444" checksum="23950E9BA113DCE1" modified="2013-06-26" version="1">MVQQQTSAPHLLVPDIFPRNDIHHTAQWSAPNATTEAGGLSRLSGTTYDRHVRDWFKDQISALGADSYAVNGTGSQFATFKGEDGSVPPIAMGSHLDSVATGGRFDGPLGVIGALEVVRSLKESGIKTFAPLVLINWTNEEGARFFPPLGSSSVFAGQSTVAAAHESKANDGSGETLGDALQSIGYVGDGPNTFHDFPLSAHFEIHVEQAASLEKAGKPVGWVEGWQGICVFEMVFRGEDGHANTYPMEGRCDSLLGACKVITETETLAHSYNGYTTVTNIQSGPVGSCNIQSWTRIVFCLMHPESLKLSAMGEEIKERAQARATLGGLELETARIMHLEPGEFWPEAVDCVRRACGDKGMPARTGTAHDSTMTTLLCPTAMVFARAKDGVSHCAKEWTSREDCAESATVLGKAVLNFDEILRERSGRRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKW3</accession>
    <name>N1PKW3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_46184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKW3"/>
    <dbReference type="STRING" id="675120.N1PKW3"/>
    <dbReference type="eggNOG" id="KOG1505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020083_0_0_1"/>
    <dbReference type="OMA" id="NAYMAWT"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="130"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="619"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME42739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="676" mass="74461" checksum="0C3998A1E1F0DBCF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLA1</accession>
    <name>N1PLA1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_134384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLA1"/>
    <dbReference type="STRING" id="675120.N1PLA1"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_0_1_1"/>
    <dbReference type="OMA" id="WVFTHFT"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF10">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME42091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="61890" checksum="D71D4762325A1165" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLD7</accession>
    <name>N1PLD7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_53460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLD7"/>
    <dbReference type="HOGENOM" id="CLU_1234994_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="224" mass="24397" checksum="A2EBE35EF750A54B" modified="2013-06-26" version="1">MDTTISKQSSTIDDLNAKASAAIKKLETKKNELNTEFRMQATIITNVTTANRHCQEELNIRTNALASAKMEILELSASVDVLDWQKSALECRCANLSEDNKDMRMVARWTQREADSHRGAAHEQFPKLPVHLAELLGQVDAIAAESACEDPQPQSASDRTQFHTDLKSAPPSSRTSGGDTTLSPPLEVPSRAKPTDAFMFDYSSENAMACMGNGDPQNASADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM74</accession>
    <name>N1PM74_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_89975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM74"/>
    <dbReference type="STRING" id="675120.N1PM74"/>
    <dbReference type="eggNOG" id="ENOG502RJY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012440_1_0_1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="595"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME42640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="641" mass="72451" checksum="A356FED99C7FB024" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP91</accession>
    <name>N1PP91_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_72262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP91"/>
    <dbReference type="STRING" id="675120.N1PP91"/>
    <dbReference type="eggNOG" id="ENOG502QVV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008471_0_0_1"/>
    <dbReference type="OMA" id="NSPLIEW"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="654"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="734"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="663"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME44748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="825" mass="91750" checksum="6B2B0F2730246FA5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPM2</accession>
    <name>N1PPM2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPM2"/>
    <dbReference type="HOGENOM" id="CLU_2460716_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="89" mass="10244" checksum="944B28C5CBC830B7" modified="2013-06-26" version="1" fragment="single">DHVHRSSKIRIWKTRQHGAPHNRAGSIPGQNNSLSKRSRVRHGKRPQLHRTGCFAGNLLLCHTENDGVRWPSARPSIPQQQERGLKEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPW9</accession>
    <name>N1PPW9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_24468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPW9"/>
    <dbReference type="eggNOG" id="ENOG502TAXQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2320338_0_0_1"/>
    <dbReference type="OMA" id="FICCECR"/>
    <dbReference type="OrthoDB" id="3833019at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="99" mass="10754" checksum="F5E91E0590F56140" modified="2013-06-26" version="1">MAAQNDIEMQYQASEQMSQANQASAGSSEQAVRSSPLSPDILVVWLMNNKCSQNKTEEKAKRTFLGMRGGGIILDLCACFICCECMEGCCHAVDDCCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQC1</accession>
    <name>N1PQC1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 79 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_128798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQC1"/>
    <dbReference type="eggNOG" id="ENOG502SNBU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022148_0_1_1"/>
    <dbReference type="OMA" id="AYANEFK"/>
    <dbReference type="OrthoDB" id="2831684at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110048" evidence="1">
        <location>
            <begin position="20"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="379"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="486" mass="52012" checksum="52DEE6430BE9C05D" modified="2013-06-26" version="1">MSYLLQLVGLTILPSLVSGQYNVTIPAAPSSATVDRSFAGFAFEQASFFNFAFDANGSTNTFSVNLIDSVANRTGGIPILRVGGTSGDLATVNTSQAQAVNLPATNYGPSTSPALTLSPAYFDAFKMFNNAQYVFMVPLRQRNITSSLQFAQYGMAAIGNRLQALEIGNEPDFYDWFSSTAYANEFKDFQSALIDQFPGALKGLGRSFTPAAAFGAGLDTTDGISQVALHLYQANDPPNSGISYLQSRIANHTAIVANMAPFLNAVAYLRATQPNISLVLSENGNSLGNMDLAQRNNLATCLWNVDYQLYALSIGVSRVNNQQIVYPGFGMWVPVQSTWESPQVRANYYSQPFIADFIGSSGNTRVVELPINGTALVSAYVAFDGDRPSRLAIVNLALWTPSQGPRPFANVTISGLPSGIDTALMRVLSSPDGALSQDNLRYGGLRWTYESNGRESAVSQQGRNISVLNGAITLSVQAAAGTLVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQK9</accession>
    <name>N1PQK9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_71389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQK9"/>
    <dbReference type="STRING" id="675120.N1PQK9"/>
    <dbReference type="eggNOG" id="KOG2563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023132_2_1_1"/>
    <dbReference type="OMA" id="STICWTG"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME45672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="54423" checksum="01D5EF6B1A896FCA" modified="2013-06-26" version="1">MADAPHPQAHVHAHAHAHAHATNSSGVTRADLIRTLSAESRPPTRKDESHVLVQRSDTIVTSGSGGELLAHDEREHHDARSYRLYKRRFLGLAQLVLLNIVISWDWLTFAAISSTAADFFRVSESAINWLSTAFLFAFAAAAPATVWVLNRYGPKPSILVASALTLIGNWIRYAGTRVGNGHFGVVMFGQILIGLAQPFVLASPSRYSNVWFSDTGRISATAVASLANPFGGALGQFIGPLFVGDPAEVRLVPQMVLYTAIISSVAALPAPLISSKPPTPPSATAALEKLDLGQALRQLPRNGSFSLLMMPFAVYVGFFNATSSLINQIFEPYDFSETEAGIAGGILIIVGLVASAIVSPIIDRTKKYLATVKTLVPGIAACYILLIFMPGTRSLPGPYVVCALLGATSFSLLPVALELLSVVTLPVSPEVSSVIAWTGGQILGAIFIIIMDALEAYDGWHGEPRGTMIRGLIFEAVIACIAVPFVLFLGTGRFRRIAFDGNGVLAAPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQR8</accession>
    <name>N1PQR8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_130227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQR8"/>
    <dbReference type="STRING" id="675120.N1PQR8"/>
    <dbReference type="eggNOG" id="ENOG502S2QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_4_0_1"/>
    <dbReference type="OMA" id="TPFPACK"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME44700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="205" mass="22158" checksum="CE91B73F398C0B6E" modified="2013-06-26" version="1">MSTLPSSTDPSSPLHYPCSQTAILLLDYHNLVVELCGDAGISAVKQAKVVRDWALANDILVIHCLLDLNRPPPPTAKGGDRLRGFMQAGQTKAGEEHAKVAIVKAEREVTVLRQPGLRSGLNSKDIKELLARKDIKSLIMCGLSTSGCVLSTAKQATDEGYVVTIVRDGCGDRTAELHEMLLEQVLPSAAYILTGNDLLDEWGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQW6</accession>
    <name>N1PQW6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_127401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQW6"/>
    <dbReference type="eggNOG" id="ENOG502SSF2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162157_0_0_1"/>
    <dbReference type="OMA" id="FMAKHKA"/>
    <dbReference type="OrthoDB" id="4415650at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="139" mass="14979" checksum="44C7C22E5C966984" modified="2013-06-26" version="1">MSGQHDFPVLFTIDGSNRHEVILVNPGFGLNDIKKAIGACAESPNCAEVLSKYKSKESKDTVSEVKVKWASEGRDKQLWVKDTLLTDDNAEAVLRLMANSGIGKDTFDVKIESKPESSSQSKAGAGSEKKASPGVPKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR78</accession>
    <name>N1PR78_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_71240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR78"/>
    <dbReference type="STRING" id="675120.N1PR78"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OMA" id="CSEADHA"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME45443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="503" mass="56585" checksum="E03E061B797C91DE" modified="2013-06-26" version="1">MELQVMLSFGLAETTLSIAALLFLAPTTLALYNLYLHPLRHYPGPAPFCAFRLRWVMAMQSGDIHRILLDLHNKYGPIVRIAPNELSYIDPQAVKDIYQNPRIHRAEVWFPPRPGEPFTIMSADEDAHAKYKKAFLGGFTEKAIREHSSLMEKYVELMINKLIDTCTSSPRAAAVDIIDWLNMVTFDISGDLSFGSPFGSIQQGKAHPWVDISNQFGKGIALMASLNFYPGLVKLLKYSMPRKAMQNLKYHKKLTTEKLAERLETTADRKDFIQSILDHNADSMVREKVKQVSRTEIEVNMPVVLFAGSETTSSAIGSTLWYLLRNPKWLDRAQVEIRGAFSAEAQIIVSGLSRLEVLTAIISEGLRLGPPSVIGVPRITGKGGDIVCGRFVPGGTMLAMSQYPAFRSATNFRHPEAFDPGRFLASAKARVSPIFRPFLVGRHVCIGERFAWAEMRLIIARLLFSFDITLDEGSPSLTDWGEQKTFIFWQKEPLRIKLKPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR81</accession>
    <name>N1PR81_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_22021</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR81"/>
    <dbReference type="STRING" id="675120.N1PR81"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_7_1"/>
    <dbReference type="OMA" id="WPPRLAT"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005275">
        <property type="term" value="F:amine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF21">
        <property type="entry name" value="DITYROSINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108984" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="78"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME45897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="513" mass="55623" checksum="B5FC8226998E4126" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRW4</accession>
    <name>N1PRW4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_87968</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRW4"/>
    <dbReference type="STRING" id="675120.N1PRW4"/>
    <dbReference type="eggNOG" id="KOG0169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002738_3_1_1"/>
    <dbReference type="OMA" id="DAWDNDE"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF169">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="10">
        <location>
            <begin position="309"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="421"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME45683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="594" mass="65993" checksum="88222AE2605AE52D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS06</accession>
    <name>N1PS06_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_22343</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS06"/>
    <dbReference type="STRING" id="675120.N1PS06"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_358251_0_0_1"/>
    <dbReference type="OMA" id="GKRVHFC"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF30">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME46246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="782" mass="86940" checksum="6C5C8D67D560D1B3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSB5</accession>
    <name>N1PSB5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_52578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSB5"/>
    <dbReference type="STRING" id="675120.N1PSB5"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034311_1_0_1"/>
    <dbReference type="OMA" id="EDLWWAP"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME45255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="380" mass="40797" checksum="B3601627CEE20FFA" modified="2013-06-26" version="1">MSAHPHAVILGAGVIGLTNAVFLSEAGYRVTVIAAHVPGDSSIEYTSPWAGAHWRTHATTDTPEQCDWDVQTFQYWLNILEGEDRNPNLPKSGLKLQQSIHLWDTEISEDLWWAPHVLGFKQLSLHHEPILSINRNRPGYAPEIVWGATSKACSVHVPQYLLYLQERARKHGSIVFQSRLPTDGGLGKALATAEGIVRVIGRPKVDCFVNCTGLGAAKLCGDAAMFPIRGQTILVKGEANATRTRYHGGAIGTGSSSYCIPRPGSGTTILGGTKEKGSWIEEADPKTTKTILERCSWMAPELLTSEDGGFEVISAQAGLRPGREGGPRTERQVVGGRKVVHAYGHAGGGYQNSIGAARKVLKLVAESVGKSSHGGVSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSB9</accession>
    <name>N1PSB9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_43627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSB9"/>
    <dbReference type="HOGENOM" id="CLU_2849662_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="65" mass="7306" checksum="67EB9D70555B0D3F" modified="2013-06-26" version="1">MPTLRAVYFSIRAGTLFNTLRSYQSDAFWKASGPVLAENDFAEDLFDGAFPLIATQMSKTLEIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSL2</accession>
    <name>N1PSL2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FRG1-like family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_60657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSL2"/>
    <dbReference type="STRING" id="675120.N1PSL2"/>
    <dbReference type="eggNOG" id="KOG3962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062276_2_0_1"/>
    <dbReference type="OMA" id="ACDVNGK"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME45923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29480" checksum="A92189E8E930740A" modified="2013-06-26" version="1">MVKPLTFKGDNPAKKRKRTHDDDAATDAPSSKALVTDTVEDDENWVSADTIDDISGPVMLVLSGDKAACMAVDQFGKVFTSGVENMVENEPSTAEPHDVRQVWVSQRIVGTQDGFTLKGHHGRYLGCDQYGFLSAAREAVSPEETFKITASSNAGLFNISNTRSDKTRFVTVDNDKSPAEIRGDAEDADETTAVRVRMQARFKPRHKVEKAEKVRAKISRKELEDGVGRRLDDEEVKKLKKARREGNYHEVMLDVKVKGKHDKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSV8</accession>
    <name>N1PSV8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_71269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSV8"/>
    <dbReference type="STRING" id="675120.N1PSV8"/>
    <dbReference type="eggNOG" id="KOG1324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_2_1_1"/>
    <dbReference type="OMA" id="QYEFQMW"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="7">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME45499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="198" mass="22106" checksum="8B0B61DD191103FE" modified="2013-06-26" version="1">MLKKDMAYFARVTKRAPVPRNTGSLQSDTLKESILKGTSRNVVIMGRKTWESIPPKRRPLPERTNIVITSQNRSDLDDIPDDVVVASDIQSGLKTLEDMVKQGRSLPATRAFVIGGASIYKAALELPQANRILMTRISKDYECDTFFPDVLDDTASGWQPASHAEHHNFVGEDIDDGPVSQAVGEEDISMKFQLYERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT38</accession>
    <name>N1PT38_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_71295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT38"/>
    <dbReference type="STRING" id="675120.N1PT38"/>
    <dbReference type="eggNOG" id="KOG3007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_0_1_1"/>
    <dbReference type="OMA" id="IYCCTPS"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000577">
        <property type="entry name" value="Proline utilization protein PrnX, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="51405" checksum="98BCDB70685B8294" modified="2013-06-26" version="1">MPLTVLGNQDVSRILHSLDKDAILELQQSLGDALHWYSTSADDNDFCSDFQPERTQIKRKDGSTTLFMPASSMHGQAVKVLNITTPSDASGLPALAEDMSLSSDGDSRSSIHSPTRQGSVASTNTNSSSSSRKATTPAGSEPGATPYLQSETSAVEMVKGTLTLLDKEGNTTGLINAEEMTAFRTALASTMLLNKRHSVHDMTVFGAGKQAYWHIRLALLLRGPEIHHLNIVTRNFESARQCIMRIYNPQPDEIDFINHIGHKYNSKTKVNLLTPMHTEYQRLLKEYVRASNIIFCCTPSTSPLFPATYLTNPEGRKKGRYIACIGSYKPSMVELHPDVLKYAVTPHHEHKHLHKRQKEGGAILVDTVSGCLKEAGEVVQAKLTPDQVVELGELLMLKRDAEQRARDNGEKTDEGCHLQNSSGLKEWLTRGNVIYKSVGLGLMDVVVGNDLLVKAQVRGIGTTIENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT43</accession>
    <name>N1PT43_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_87081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT43"/>
    <dbReference type="STRING" id="675120.N1PT43"/>
    <dbReference type="eggNOG" id="ENOG502R8N6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_339524_0_0_1"/>
    <dbReference type="OMA" id="MYPHEMA"/>
    <dbReference type="OrthoDB" id="3794485at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="862" mass="93819" checksum="A9D061123195B849" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT99</accession>
    <name>N1PT99_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_43888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT99"/>
    <dbReference type="HOGENOM" id="CLU_1189898_0_0_1"/>
    <dbReference type="OrthoDB" id="10671348at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="233" mass="25468" checksum="586940E85C91AB56" modified="2013-06-26" version="1">MHRDFLDMMTITSITANTFDSHSDTGSVNNASQRSSTTSLIDELQDVAEISASNKTLVSYHDLLRHTNGGLILRTLHGFPYINDVNDTDLRRRTSTNTTSTIASTRGAHSSIQTEEAFTVRRMSGRVSFLCTSSSALTDVDMSRPHTATSNNEEGVLQARITSVSALPSSPARSRHNFSFSEDISASMCGCRALITALCKRLARQKSHEPTAAPSIHSLQATALPSHFQLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTA8</accession>
    <name>N1PTA8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_70574</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTA8"/>
    <dbReference type="STRING" id="675120.N1PTA8"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_2_1"/>
    <dbReference type="OMA" id="YVSGWQV"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="423"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME46602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="537" mass="59565" checksum="3482FC61A34CE20A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTC9</accession>
    <name>N1PTC9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTC9"/>
    <dbReference type="HOGENOM" id="CLU_2904169_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="62" mass="6630" checksum="C8FAF122BC2E7BE7" modified="2013-06-26" version="1">MRPTSQPSMLGPGLAKQTRNRLWFRKSGTGYLPPDSVCFARAGQLCAFGAVHAHTSAAVAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTR9</accession>
    <name>N1PTR9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_52165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTR9"/>
    <dbReference type="STRING" id="675120.N1PTR9"/>
    <dbReference type="eggNOG" id="ENOG502S832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_280337_0_0_1"/>
    <dbReference type="OMA" id="SICCLWK"/>
    <dbReference type="OrthoDB" id="5349119at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="347"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="513"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="796"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="871"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="905"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="927"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME46772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1121" mass="121594" checksum="761681B7DED54C36" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTU6</accession>
    <name>N1PTU6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_110508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTU6"/>
    <dbReference type="eggNOG" id="ENOG502S6HE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062260_1_0_1"/>
    <dbReference type="OMA" id="GHYTTYP"/>
    <dbReference type="OrthoDB" id="3223416at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="14797" checksum="4DA577A55558196F" modified="2013-06-26" version="1" fragment="single">LNITAIDAANSSSILQCWQLTPFTVSSTPGTVGALSAFFGEASNISYTVIPPRTNAGLHVAPAAQFVIFLSGLIHLTLPNSTQEAWVAGGKYGVIFAADTKDRSTFGHITNYPANEDTVVVQVPLAPGMELNHTVLHEGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTW1</accession>
    <name>N1PTW1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTW1"/>
    <dbReference type="HOGENOM" id="CLU_1835129_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="140" mass="15540" checksum="81D1FF3FCB17F6E4" modified="2013-06-26" version="1">MRTLGSRHPTSPLKKALGELDVTGRLLVNELVTLASTSSFFALCTSSIKVRSVESQLRPHRAEASIASRGRTQSSQYRELQADPSMGATSRSQILGPGLERTRLLREVMRQWITPLTRKTVAYLNYSEPMNIGEAWTAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV11</accession>
    <name>N1PV11_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_145652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV11"/>
    <dbReference type="STRING" id="675120.N1PV11"/>
    <dbReference type="eggNOG" id="KOG2522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012487_1_0_1"/>
    <dbReference type="OMA" id="MFLKPYR"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21156">
        <property type="entry name" value="PUA_eIF2d-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000008">
        <property type="entry name" value="eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
        <property type="entry name" value="SWIB_eIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26291">
        <property type="entry name" value="SWIB_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="547"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="642" mass="70358" checksum="1A0D0A78084CAE81" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV78</accession>
    <name>N1PV78_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV78"/>
    <dbReference type="HOGENOM" id="CLU_2497872_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="86" mass="8954" checksum="F27CAE6027BA4624" modified="2013-06-26" version="1">MTGLLYAKGALDGGGCNASGSGSGNNGVVSRASIACVYPGRQTRKMDRATNVTSAFKTQANGCCFGSRDNGRAVAATSRWEGRWWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV85</accession>
    <name>N1PV85_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_70728</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV85"/>
    <dbReference type="STRING" id="675120.N1PV85"/>
    <dbReference type="eggNOG" id="ENOG502QPVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011455_1_1_1"/>
    <dbReference type="OMA" id="MQIGLHQ"/>
    <dbReference type="OrthoDB" id="2341546at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="85"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="659"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME46858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="751" mass="82419" checksum="C22EE504B70E6CDE" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVJ1</accession>
    <name>N1PVJ1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Versicolorin reductase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dothistromin biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_69435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVJ1"/>
    <dbReference type="STRING" id="675120.N1PVJ1"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="EFHSCDV"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME47491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="278" mass="28976" checksum="ED63272EE15E1721" modified="2013-06-26" version="1">MSAEADVKLNDFKNIFSLAGKVAVITGGSRGLGLHAASGLAQAGCSKIFITSRKAKACEEAVAALNALPGNCQAISVPADIAKAGEVERLVKEVERHTDHVDILFANAGATWGEEFDKHPENAFQKVMDLNVKSVFVCSQKFAPLLRKRGTIQDPSRIIVTASIAGIGVGTLGKQGTYGYSASKAAALHLSRNLALELGPQGILVNNLAPGFFPTKMANGLMEMSGGVEKLADFSPNKRLGHPEDVAAAVVFLCSRGGSHINGGTLVLDGGSVLQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW13</accession>
    <name>N1PW13_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_145504</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW13"/>
    <dbReference type="STRING" id="675120.N1PW13"/>
    <dbReference type="ESTHER" id="mycp1-n1pw13">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_15_0_1"/>
    <dbReference type="OMA" id="CPIRYVA"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME47118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="509" mass="54431" checksum="56EE313E7DEB5ADF" modified="2013-06-26" version="1">MPFAQSPPERFSPPQKQGVGSCNIDATAWKPACIQQFVYPKIAQEFVEAVFNSPAPEESEDCLYLNVYAPSSPAPEGGRAVMFWIYGGALQFGNAGQTYYDGSSFAAYEDVIVVTSNYRTNVFGFATSPELPIAEQNLGFLDQRAGLDWVQRNIAAFGGSPHKVTIFGESAGGFSVDALLTSFPKNSTPPFRGAIMESGQYSYSAQPRTSTVPIWNQLAGLLNCTTSYTSNLTCLRAANASTIKNAIEVHILEFNPVADNVTLVHNPMQQRLSGNIAHVPILGGSNAQEGRVFTVGQTNSTTYLRTILGNNTAAITALESAYSPYHASNGTEAYTQVSEIVTESVFQCPAAYQANATASIGIPAWRYYFNASFSNTQAYSNLGVYHASEIPIVFSTYPRVNVTAQEYALSRAMRGMWATFAKNPAGGPGWNPVGSGKPGTVLVGAMSEAEGGLIMNGNETFYGAYNVGLLGNRGDALSSGVTVIDGSEIDYRCGLYAATYNGFANIDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW44</accession>
    <name>N1PW44_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Urea carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_51063</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW44"/>
    <dbReference type="STRING" id="675120.N1PW44"/>
    <dbReference type="eggNOG" id="KOG0238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002162_0_1_1"/>
    <dbReference type="OMA" id="TLQMWNR"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF128">
        <property type="entry name" value="UREA AMIDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160467">
        <property type="entry name" value="PH0987 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="3"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="119"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="1150"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1096"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME47721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1235" mass="135821" checksum="6E479921EE38D0B4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWS4</accession>
    <name>N1PWS4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_33397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWS4"/>
    <dbReference type="HOGENOM" id="CLU_1927547_0_0_1"/>
    <dbReference type="OMA" id="AIVNDCY"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="131" mass="14630" checksum="07339554923855FF" modified="2013-06-26" version="1">MIYQTPLFNLHPSTSVTNTELVLDMGKNTTKPSANARNHSKTDDITSAQQAKNERNLAKFPMTPGEIVKNWMGRSGCLRDYLTGDTVMSRDIVHNRVGSLDVSFNLSTEQGALRVDGVNLGDHRREKLEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXX5</accession>
    <name>N1PXX5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_101392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXX5"/>
    <dbReference type="STRING" id="675120.N1PXX5"/>
    <dbReference type="HOGENOM" id="CLU_004184_6_0_1"/>
    <dbReference type="OMA" id="CYWIDAL"/>
    <dbReference type="OrthoDB" id="3553147at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="134" mass="14984" checksum="8189C81A31CA8D1B" modified="2013-06-26" version="1" fragment="single">YIALSYCWGDPSITKSITLGDYQIQVTENLSNALTSIVQHHDRDACYWIDALCINQNNIPERNHHVQRMGTVYSSARLVSAWLGPEDAETETAFSEITLLASANIANRDEPPDQRVATAIGSLASRPYFDRAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q024</accession>
    <name>N1Q024_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Las1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_124919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q024"/>
    <dbReference type="STRING" id="675120.N1Q024"/>
    <dbReference type="eggNOG" id="KOG2425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019519_0_0_1"/>
    <dbReference type="OMA" id="WLWEWYW"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="46756" checksum="ECD11D044E52DFEB" modified="2013-06-26" version="1">MKYTITPWRHHSDLLQIRQQLYQLPKDGQDHRRHAVNRVMAWKLRGNLPHAIESTALLIDAILHHHSPENANSTFSIRAVYTAALTRFVTGFCDIGRNRERSLEPSSMLDIAKQIGMPVEFVALRHEATHEEMPGLRRLMKVTEQALGWLWQVYWSKLFDKTEDVASIAIVRDEARRILKEFRTAHRDALRANHGTAAQDVVSKTSEFCVKLCGGSRAKTNALVDVLMEDKLLSPSKRELGASMDGAFLIWDSLLRGIARKQRRFISALVKGMLEAISASFARPAGQDVDKEALSMWLIRIELDETWMAIRSDLEQHDLETEVLMWSSLHANDWTSWLGQKMLEFGRSQSKSEWAEILEASRLDCREAADHSMPDEKPLDAWPIDGTASHSVHSPWSRSVMPGSRPIGVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q049</accession>
    <name>N1Q049_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_67992</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q049"/>
    <dbReference type="STRING" id="675120.N1Q049"/>
    <dbReference type="eggNOG" id="ENOG502S7CA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034573_0_0_1"/>
    <dbReference type="OMA" id="HAAHECG"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME49116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="561" mass="60551" checksum="2777ACF321DE2FAA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q080</accession>
    <name>N1Q080_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_57974</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q080"/>
    <dbReference type="STRING" id="675120.N1Q080"/>
    <dbReference type="eggNOG" id="KOG0221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_8_0_1"/>
    <dbReference type="OMA" id="CSVYFMP"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME48663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="858" mass="94976" checksum="29BBC3329684EFA0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0P4</accession>
    <name>N1Q0P4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0P4"/>
    <dbReference type="STRING" id="675120.N1Q0P4"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OMA" id="ILVEYYG"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF194">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="459"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="559" mass="61602" checksum="961E72BA67024AB9" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0T0</accession>
    <name>N1Q0T0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_121760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0T0"/>
    <dbReference type="STRING" id="675120.N1Q0T0"/>
    <dbReference type="eggNOG" id="KOG2154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015945_1_0_1"/>
    <dbReference type="OMA" id="YYNNIVT"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="6">
        <location>
            <begin position="320"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="551" mass="62534" checksum="8D1A7BCE5B5FF513" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0U4</accession>
    <name>N1Q0U4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_143148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0U4"/>
    <dbReference type="HOGENOM" id="CLU_011409_7_1_1"/>
    <dbReference type="OMA" id="QGREEFW"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="55860" checksum="9EEC9B02133E55F1" modified="2013-06-26" version="1">MRAMVIDMDMAESCAFDFFRREATSQLPGSSLDWKRLVLQTSYGEPSLAHAATAIGFLIQSYGSPSAIARNGVDHHALALRHYNKSIYHAARYIENLSAGPGSASIEVILLLSLLFFSFEVLSGEDMRACAHLRTGLRVLYEKVRDPLSNTCSDKRVVVMHPVPRNEMELLLNTFVRLDGDPTLTDQYETYLHAIVAESIPNFFSSLEEAQVHLDGIESTVLDLFHELDKSYGRPLVGLHWGTSALSREELFCLSSAYSRYVPMETHPHLTERMDVAKSELQAWCRALAMLPHQEEHAAARLMLQIKHLDLWIETSKWKDENEIMGDRFDKEYAHLLNLSEQYVGLHLDVDLPIGTVPTTRPGFCVGTALIANIAGIAWYCRNPRTRRRCIALIRRINMRGVADSEYLAAVSEKVMEVEETQARLSRGKDPDEELMSGDIPEEARVIEVEMCPHQGREEFWKLHEGRIVYVTSANGAGSELSLHEVAFVVRRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q118</accession>
    <name>N1Q118_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q118"/>
    <dbReference type="STRING" id="675120.N1Q118"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_2_3_1"/>
    <dbReference type="OMA" id="PEFMNGH"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF105">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G08790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="287" mass="31411" checksum="9A0B917C243A1826" modified="2013-06-26" version="1">MTLKPCCASGSLHTGTPTGSFEKKHGLDCYVADAPNGTPKGIIVIIPDAFGITLPNNQILADDYAKNGFTVYLPEFMDGAGVPSEVFDSMKFITTSTGIWNQVTKISHIAYVARHLLPFLYFTRRAVCQPRIYDFLKAMKKNEAKDLPIGTAGFCWGGQHVTALCHDKVKAEDGGRLTVCGFVAHPSFLTYPGDIEGIKLPYSCAAAEIDPQMSPENAKKTKDILQAKTAKAKDQGIEHEFVMYDKVNHGFAVRADENDKLEAEAGKKAEGQAVRWFEKWFANPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q159</accession>
    <name>N1Q159_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_162981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q159"/>
    <dbReference type="STRING" id="675120.N1Q159"/>
    <dbReference type="eggNOG" id="ENOG502SFSH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078568_1_0_1"/>
    <dbReference type="OMA" id="SDWGNRT"/>
    <dbReference type="OrthoDB" id="5336357at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="206" mass="23194" checksum="69DC22C0E8F98C3A" modified="2013-06-26" version="1">MAIKRKRPSPGFSSPSSTGSDTTIQSSPLPSFYHRSTLIAPLYHKPTWSFPTYDDSPSSQYLNSRTRKRHRDNRPDAQQIHAHTIDRLYQAQRQHPDASPVLSQPVVQAQHPTQPQRSTLHSFWRIGQPPSTTMMAVDPGPMRLDTHMSFHCEDCDRPLKPADAMDVDEEILNQETRCASCERSICDTCAILGTSRTCLACASRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1R3</accession>
    <name>N1Q1R3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_84065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1R3"/>
    <dbReference type="STRING" id="675120.N1Q1R3"/>
    <dbReference type="eggNOG" id="KOG3211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053568_0_1_1"/>
    <dbReference type="OMA" id="LQVLYYW"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME48439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="295" mass="31438" checksum="50EEBB6BB409B0F2" modified="2013-06-26" version="1">MESFEQALRSVLQPITRNLPKPLSDAATNLLGDSCYRSLVHNVTITDTVCLKLAISKALGVAIITMSSIVKLPQLLKLLNSQSADGISFLSYLLETASYLVTLVYNVRNQFPFSTYGEVALIAVQNVAISVLVLQYSGKAAGAVAFVAGLAAAGYALYNESLVSMDMLQYCQAGAGLLGVASKLPQIVAIARQGGTGQLSAFAVFNYLAGSLARVFTTLQEVDDKLILYGFLAGFTLNLILAAQMIYYWNSPSSKDSKQTKLQPSGKQALSSATRASKATGSEKAQKSPSTRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1S3</accession>
    <name>N1Q1S3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 64 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1S3"/>
    <dbReference type="STRING" id="675120.N1Q1S3"/>
    <dbReference type="eggNOG" id="ENOG502R3TN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032886_2_0_1"/>
    <dbReference type="OMA" id="FCEFTWN"/>
    <dbReference type="OrthoDB" id="10058186at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09220">
        <property type="entry name" value="GH64-GluB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.50">
        <property type="entry name" value="Beta-1,3-glucanase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042517">
        <property type="entry name" value="Glyco_hydro_64_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165:SF1">
        <property type="entry name" value="GLUCANASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52006">
        <property type="entry name" value="GH64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH64" evidence="2">
        <location>
            <begin position="82"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="459" mass="48847" checksum="895A0B0616DA60CD" modified="2013-06-26" version="1">MGSLVEGIRSFVKRHLRKHHHQPARESKYYSPSLPANPDPQDGQPAATPPQDQPAGQQSRPQTIRVHNRAAVMPTAQAATTTGTLQIALMNQSNSSQVYAYITGRAIDNNDAVFMLQADARTPYYPASPSKVGSPVPVNIAISLGAPGNTVTATIPRLAGARIWFSIGNPLTFLLNPGPGVVEPSVFNRSDPNYNINFGFCEFTFNSAQVFVNISYVDFVSNVPIALTLADTSGGSQHVAGMSSDGLATVAKGLRAQTVADGRRWGSLIVQSGGKDLRALSPNSGITTNPTWFETYWTDYVNQVWDKYSSQQLIVDTQASWGEVKGQVNSSGYLDFGDGSTFSKPTSADIFSSNSGPFATGGNAKTNAIIPRLCAGFNRSTLLASDQAPNGTSPPQYYQNAITNHYSRIVHAANVDGLGYAWPYDDVAPDGGAPQEGAIFSFSPSKLTVTAGGNNAYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1U1</accession>
    <name>N1Q1U1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_164323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1U1"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029389_3_0_1"/>
    <dbReference type="OMA" id="KMVTMFS"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="324" mass="36029" checksum="26B54115929470F7" modified="2013-06-26" version="1">MADQGRPPRKKSLLIGINYVGSEHKLQGCHQDVENMMEFLAAEGYSSDRRDRVVLRDDQHTDPNGPFWPNGHNMMAAFQWLVSEPGTTNFLHYSGHGGQVADTGGYRVSGFDDTIVPVDFERNGQIPSGVLHKALVSALPPSSTLFIILDCCHSGSAVELPYVYRSDEDGNVSMLDNVQAGMRLMGAASHLIQGGFTVDKVGEARQLFAGAQSFFKGLMHEQAETDQYGLSQEDFAQEYQREQPKQVWMYSGCKDDQTSADASIAGSHVGAMSWAFLECMKQYGLRQSYIQVLQNTRQILKGRYQQVPQLSVGFEQDLNYGLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2C1</accession>
    <name>N1Q2C1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_40617</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2C1"/>
    <dbReference type="STRING" id="675120.N1Q2C1"/>
    <dbReference type="eggNOG" id="KOG0860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064620_2_1_1"/>
    <dbReference type="OMA" id="VRKKMWW"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090619">
        <property type="term" value="C:meiotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME49393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="117" mass="13207" checksum="99DD4EB9D6978A45" modified="2013-06-26" version="1">MASTNNDSLYDPYVKRGAEEGTAGNARTQGLQSEIDGAVRTMQNNITKISERGERLDNLQDKTDHLSTQANSFRRGANRVRKQMWWKDMKMRMCIIVGIIILLVVIIVPSVVATRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2H9</accession>
    <name>N1Q2H9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF6314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_67798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2H9"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023116_0_0_1"/>
    <dbReference type="OMA" id="GQFPMGD"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="5">
        <location>
            <begin position="585"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME48855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="756" mass="82914" checksum="E245978DA7778273" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2N6</accession>
    <name>N1Q2N6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_30272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2N6"/>
    <dbReference type="STRING" id="675120.N1Q2N6"/>
    <dbReference type="eggNOG" id="ENOG502RANQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_540811_0_0_1"/>
    <dbReference type="OMA" id="HIYELTF"/>
    <dbReference type="OrthoDB" id="3905718at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="101"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="101"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME48915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="504" mass="56284" checksum="F358B5A0A0EC24E5" modified="2013-06-26" version="1">MGHAISTPHLARAADDSPAATPEEHKKPPCSSRNINTPANDSDRRVRAVLSPTTQAIAHSSSDMTSNAADAMPAPAATSPCEQLRKEILALAHPHRAATKLPPFSAGELIVMALVCKDSEDLQAPDILRWIVKHFKHYGNRALEEYTRRIDGGNRWREEVRVVVPGFNAALDHYELPVSRRCEFNHIPDYIYSIDTAAARLYLRGYLAKKATGTFPFLRLPAELRNHIYELTFCFAKGRGIFVDNVKTGGLSMLAQHPGDDSYAKDWWNYSYETGNQTCVIGRRDVRHLPPTKDILALLLVCKQISGEALPYFYQLNPLHINTLKKLTAVAHRMAPSRLEHLNHLSIELMGDHRYHDDVASFSRFPQTVEALKAIKDLKMLEIETTDKMWLSMRPASRQSLGRKTPFKKFAQIPGMKELARLAESAVSFNLRGNSAPELQKYLDSEAQLIKTARDKQGEVQGTEQTKGKKRKATVESADGTAGGERRVRKIKKAPGSHEAGNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2X7</accession>
    <name>N1Q2X7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_67901</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2X7"/>
    <dbReference type="STRING" id="675120.N1Q2X7"/>
    <dbReference type="eggNOG" id="ENOG502QRP5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010191_1_0_1"/>
    <dbReference type="OMA" id="NVFGWVN"/>
    <dbReference type="OrthoDB" id="5356111at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="614"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="670"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="733"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME49015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="784" mass="85839" checksum="FDB8CD167FBC2D4F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q378</accession>
    <name>N1Q378_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q378"/>
    <dbReference type="STRING" id="675120.N1Q378"/>
    <dbReference type="eggNOG" id="ENOG502RYQG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013054_0_0_1"/>
    <dbReference type="OMA" id="FQDQGME"/>
    <dbReference type="OrthoDB" id="5352000at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME50132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="850" mass="90887" checksum="256B4EFFB1970B96" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q388</accession>
    <name>N1Q388_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_102418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q388"/>
    <dbReference type="STRING" id="675120.N1Q388"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="OMA" id="QFVWIAD"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME50142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="250" mass="28887" checksum="BAC784001D9C97F2" modified="2013-06-26" version="1" fragment="single">MRLIDTDNLELYEFSEEQIPFGRFAVISHRWTNDEVTFKEYRRGLKKDSTGYQKIINSCSLAKSRNLEYVWIDTCCIDKRSSAELSEAINSMFRWYQRSAECYVHLPDVSLVSLGPDRRAPNLLVGSDWFTRGWTLQELLAPSKVLFFDEGWFPIGARSDDDMASTISQITGIQTYDLNQFSHLRASVARKMSWASKRKTTRPEDLAYSLLGLFDVNMPLLYGEGSAKAFMRLQLEIIRKTADKSIFAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q393</accession>
    <name>N1Q393_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alkaline ceramidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_67988</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q393"/>
    <dbReference type="STRING" id="675120.N1Q393"/>
    <dbReference type="eggNOG" id="KOG2329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063293_2_0_1"/>
    <dbReference type="OMA" id="IMFEPLR"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME49110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="37832" checksum="7934593153C47A79" modified="2013-06-26" version="1">MPSWLPSVPYPPARDYGYWHPITATIDWCEENYYATIYSAEIVNSLTNLIFVWLAIVGMRSCALHGHDKIFFVTFAGYLLTGLGSFSFHSTLKYSYQLVDELSMIYTTCLMTWASFAHRRSGIFQIVLAVLVFALALFITLYYHYLQDPSFHQNAYAILTAVVLARSIWIMETEIRPYFRSRLEERRKSQGYAATAEHDRVEQRRQDDRDRWIVGQMWTMIAFGLTIFLGGFGIWTLDNEYCSKVRQWRHEIGLPWGILLEGHGWWHLFTGLGAYFYIVWGIWLRHCLNGRQDEYELLWPSKLTSIPRIVRARGTANGFAKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3R6</accession>
    <name>N1Q3R6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_49600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3R6"/>
    <dbReference type="STRING" id="675120.N1Q3R6"/>
    <dbReference type="eggNOG" id="ENOG502TDXJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_331496_0_0_1"/>
    <dbReference type="OMA" id="WEWYDEN"/>
    <dbReference type="OrthoDB" id="3943769at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="864" mass="96498" checksum="D4D1B2F6C41DEF59" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q420</accession>
    <name>N1Q420_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_40485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q420"/>
    <dbReference type="HOGENOM" id="CLU_3068645_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="53" mass="5763" checksum="F7A18FA408505B75" modified="2013-06-26" version="1">MTGCRRFREDPESVFRDGKGDCDRLNGASSPVGPTGPRASSLPIFLQRPDPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q479</accession>
    <name>N1Q479_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q479"/>
    <dbReference type="STRING" id="675120.N1Q479"/>
    <dbReference type="eggNOG" id="ENOG502STYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058869_0_0_1"/>
    <dbReference type="OMA" id="SHPPGYQ"/>
    <dbReference type="OrthoDB" id="5385910at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="249" mass="25842" checksum="3E04AD52B00558A1" modified="2013-06-26" version="1">MPPIQVHIDDPITPKKAEGMTPRTSEAATPPSAAEASTTQARSQYPAARPGAAAVPAATPYAPQPGPQPTPTRIIHSSSNDAPPPPQPGEAPVPFGTSTPVTATLLPPPPKAGEPMPVTTMPAQMGVSSPQHNYKPTHSTSTYSPLGRAGGPTTVNFGAVPAPTPTIVGSHPPGYHQNVDAQEMSSAQRASLDAEQRRGSFAPGLGMGGNDSNDFSAGSVWNTMKTYANFAGNKLAETEKEVWKRINKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4U0</accession>
    <name>N1Q4U0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_20296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4U0"/>
    <dbReference type="HOGENOM" id="CLU_2483327_0_0_1"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10064" checksum="D46BA58CF9DE1345" modified="2013-06-26" version="1">MVGRDDNWVTYGLSLAGRAVAWRGPLALQFMFIVPYATVPWLLESPHWLLQKDRVEDAEQIPANIEQFQIQDPYDQDELNEINFTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q527</accession>
    <name>N1Q527_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q527"/>
    <dbReference type="eggNOG" id="ENOG502SM8K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044491_0_0_1"/>
    <dbReference type="OMA" id="RHGYQRE"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="462" mass="52917" checksum="04E871140E7B65D6" modified="2013-06-26" version="1">MAIHRGIQSAIFYYLSCAPCSDARHRRRRKEEAKGERAERELLERDHPNYYRHPSPSSTNPYWQAEIDLGPHGLQRNKRKTHTADSRRRLREQNYGSESPSWDQIPPVTAGSDDSDSRWNFRRYQREDEELWGSTSNFGGSMYGEGLTKPQRAMTKDSMRSDYSEYRNPQINDMHPATVTKVTTPEEVMWMKQPPPVAAVMSGKERATRSRSDSEGSRFSPAGRPPSRSVSHRMIEQKLKAVEAATAMSRESSSRTSDGQRHERRPGTSERDFAVDPLPNEAKEKRRPSPIQVFDHSEDSDDTVVRRPSLAPEPLSRLQARRIASRPALSTIASDEAVPSNMHSSLHTPEMTKENEVPTPIHSRDGSTDVHDHFARKSELLIPGNALRERVFRNATEPSHGDYTTRRHGHRHEDSDDTMLALAPELVDIESWVEPEFDIIKWAHEFTKRDVNPRERRASMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJR1</accession>
    <name>M2WJR1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_83036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJR1"/>
    <dbReference type="HOGENOM" id="CLU_383101_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004028873" evidence="2">
        <location>
            <begin position="24"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="722" mass="80196" checksum="5615BC893F86EEFA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJS8</accession>
    <name>M2WJS8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_159405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJS8"/>
    <dbReference type="HOGENOM" id="CLU_1204735_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="230" mass="25953" checksum="3F1981CD24855115" modified="2013-05-01" version="1">MDDAAPVIDAWFPGARPYWPSQRGECWIALANARLFGLSQHGAQTNLLDQDSTSVTRPDDPSGSLARSKEMRKWSNGTLRCSPLGRGDATEQWDAGPNLYFPSNAVYLCCLPVRTWLRYSSTTLFGTSATKSLLADKKIEAPTTEAILSVLFRLFVYMHWPGLEFPGNPIQLLELLCIRRVQSVQFHHNCPHRSKREISIIVDSIIQMLSLWHVQVLHDLFHPKTFSEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2WKL0</accession>
    <name>M2WKL0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_75244</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WKL0"/>
    <dbReference type="STRING" id="675120.M2WKL0"/>
    <dbReference type="eggNOG" id="KOG3273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064992_0_2_1"/>
    <dbReference type="OMA" id="TPLRNNW"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="157"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME39513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="252" mass="27541" checksum="1B08731B8C52E0B4" modified="2013-05-01" version="1">MPAPTALQRAPEDLAIQEATHDAPQSAVEEEVLLTSTISGQPEGADAVADMEVDGQDGALFAPETVSSTVHRVEERKVRVPPHRMSPLKANWPKIYPPLVEHLKLQVRMNIAKKAVELRTSPLTTDTGAIQKGADFIQAFCLGFDLDDAIALLRLDDLYIQSFEVKDVKRLEGEHLGRAVGRIAGKDGKTKFAIENASRTRIVLADQKVHILGGFKNIHVAREAVVSLILGSPPGKVYGNLRTVAGRMKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>M2WN45</accession>
    <name>M2WN45_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_35697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WN45"/>
    <dbReference type="HOGENOM" id="CLU_1517826_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="177" mass="19949" checksum="3FFBA9850EE417EC" modified="2013-05-01" version="1">MSLLPHGDFALQAVLGSGFGCHLAILPKPSLPCNATERVHSRLIIQLFILLYQACWPNGKALDYDSFGIKRLQANARNAGYTPNKRIPQNCQDYASYLRCKVLQFDISETIHTINHLFFFDILQNVKTKLDPAILVRNTGDGQDRLKLIAARDLQIIQETERVLYSSLIQGPIADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2WN94</accession>
    <name>M2WN94_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_25421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WN94"/>
    <dbReference type="HOGENOM" id="CLU_1578499_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="169" mass="19123" checksum="61BC3446C086A5EE" modified="2013-05-01" version="1">MDSTQDVTNVNTNPTYIWDDAEANATMYDGKSRAYHEEMNESPNPEAQGIVLPLLIFEDLDQKTADETIKAKESPRKVSKKETSEMINQTKRTPEKNSATKDTPRKTTKNKAAKAKAFEGKAPTRQQQRKERDRELLDSSERSKEEVKAVEGHFNTGNRFSMLARSAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2XHE2</accession>
    <name>M2XHE2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_66840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XHE2"/>
    <dbReference type="STRING" id="675120.M2XHE2"/>
    <dbReference type="HOGENOM" id="CLU_1081927_0_0_1"/>
    <dbReference type="OrthoDB" id="3630991at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29209" checksum="608361C8FF347B0E" modified="2013-05-01" version="1">MEDHRVPIWTPSLQHDSSVTASIRRFADVQAVRTLCDQVERQIRYYGALERFRHIKQTSSKQCIDGRRITTQKVLNHRPEASFCWVTSRLALHQGNGTLADCTICLTPADDRLTLSCDRVYCRGCFEGLCISNDVNTADLKTTCRDQDDQCRRCSSAVHIRRRLHHHRFCPTANGRHIISAGCFEQHDESLSCEEHRDLLKRATGVKDCPQCKTPLEKIDGCDHMTAVAPCHVHMDEAHGGSRLPNRDNDDQEDDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M2XHI8</accession>
    <name>M2XHI8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_75575</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XHI8"/>
    <dbReference type="STRING" id="675120.M2XHI8"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021757_0_0_1"/>
    <dbReference type="OMA" id="VPVKYCK"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="476"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="649"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME38907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="710" mass="78129" checksum="7154D49631058808" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKM5</accession>
    <name>M2XKM5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="2">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_72442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="2"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKM5"/>
    <dbReference type="STRING" id="675120.M2XKM5"/>
    <dbReference type="eggNOG" id="KOG1417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1326347_0_0_1"/>
    <dbReference type="OMA" id="VECNDDP"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME43052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="207" mass="23286" checksum="06B9109B57911360" modified="2013-05-01" version="1">MYRTNSSSHHRDFAPYEAVPVVPTSLSPNSYMWPYFPAQNDAEWLHEKHLGRNGVPAAKDGCDTWIFNMTADMPKKTVLSSLDGDSLIIPHVGAMNIQTELGRLLVRQNEIAVIPWGIRHRITLPTGKAKDTICELLQGHYQLPALGAIGSTGLANTRDVSTPTAHFDGSFQNGRALTPERYRRLEHRPAPRWPLLRLHSKSHPIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2XM31</accession>
    <name>M2XM31_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_72769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XM31"/>
    <dbReference type="eggNOG" id="KOG4476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028895_5_0_1"/>
    <dbReference type="OMA" id="IEPPMAS"/>
    <dbReference type="OrthoDB" id="5319641at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="531" mass="57062" checksum="1483F7B4AFAE3D0A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y0W6</accession>
    <name>M2Y0W6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_29138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y0W6"/>
    <dbReference type="HOGENOM" id="CLU_068279_5_0_1"/>
    <dbReference type="OMA" id="PARISYD"/>
    <dbReference type="OrthoDB" id="3647113at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="35"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="255" mass="28832" checksum="18BFDE5AE6CBDE74" modified="2013-05-01" version="1">MANASNISNSLKRKVSADEDRLDKLAKLAKMNQTNAVTVKLGDNPKGFRIVHRDIICSQSAYLKRVLIGQSEDRAKIDLRVEEIPLAHFDLYLEWLYTRRSTSLDKAVTSIAKVNADKPDKGCTSSEHLDHRTFHVLVDIWLVGDLLQDTKFQDQIIRAIFRIPHELRTLATKCAALRSVMLNTPDQGSKLRRACLDLMECRVVIGDVDDLEMEDWTKDIVVLLMKRLGTLVAQGDVPRDETYVEEDSAAVEDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y142</accession>
    <name>M2Y142_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_39204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y142"/>
    <dbReference type="STRING" id="675120.M2Y142"/>
    <dbReference type="eggNOG" id="ENOG502SHQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013929_1_0_1"/>
    <dbReference type="OMA" id="EYCFANS"/>
    <dbReference type="OrthoDB" id="3636259at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="348" mass="39003" checksum="DAC5AE2C49F3C93C" modified="2013-05-01" version="1">MDETGIMLSQLGSVKVLVSKENPHSYRGARVKRVTITAIECLKLVFDPQTKDRVGQKPRVLICDGFGTHETLEVLEFCFENNITLCRLPSHTSHKLQPCDISVFGPLKAAYRDQVERLERGGVGTIGKEHFTYLYSPARERAFTSRNIRSGWAKAGLFPFDPAKVVEDLPQANIRPAGLAPGATPVTPASAEGVHALHNLMKHDTDTLDVTRRQRFQEHLKKLTNATHLSFAERALLREQNHFLAKINNEAKARRSTKTEIIGTARVMSYEDLAKARMDRALKEAEKEAKRAEKEAKKAGSARSRPKPLAPNNETQDFRDTEALRVGIEAQESRFMPGPCRAPVARMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y3Z9</accession>
    <name>M2Y3Z9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_80557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y3Z9"/>
    <dbReference type="STRING" id="675120.M2Y3Z9"/>
    <dbReference type="eggNOG" id="ENOG502REVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049215_0_0_1"/>
    <dbReference type="OMA" id="WVGRHEK"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004029230" description="Urease accessory protein UreF" evidence="4">
        <location>
            <begin position="24"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME43019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="26565" checksum="600E1C144969F743" modified="2013-05-01" version="1">MATPSLHALLLLSDSALPLGSFAFSSGLESFLGHKGLSNTHRSSSAATKLAAAEAFLEQSIVNLASTALPYVLFAYHNPSTLEDSDNDFDASTPCTVARRASIAQGRALMQIWERALLPAAGGGEAKDRVSAFAIKLKANVVDDFGLSLQAHFAPLFGAVCAALCLSVHDTAYLFLLNHAKAVLSAAVRASVIGPYQSQALLANSRLQNCIKVCIKREAASKVESAAVTVPTMDLWMGRHELLYSRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y5Q6</accession>
    <name>M2Y5Q6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_174493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y5Q6"/>
    <dbReference type="STRING" id="675120.M2Y5Q6"/>
    <dbReference type="eggNOG" id="ENOG502S025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="OMA" id="DWAIWIL"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="54"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME43579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="388" mass="41997" checksum="A51419606165A4FF" modified="2013-05-01" version="1">MIRRGFREDYDDSIPINEQPTSATAVHFGAGDIGWTAFGPSIGLSLLATVIVVLRWYTRARLVRIVGLDDWVILISLLLCWVITASIGVAIFAGIGKYHTGPGAINTILIVKLIIVVNTVWATTVNITKASILVQYLRVFNDRIIRICCWILMAALLPATCWGVFGGIFLCSPTAKLWNVQLPGHCRNAQTYWASVAGVNIGLDFLTLVLPIPVIGGLHLPRKQKFLTILVFILGFMVCGVSCVRLGTVIATADLGDPVKSGIWAVTWSAVEANVGVICASLLALKAFIVKLFPSLMEESRLPRHQMRLPEVASAGTIWNPGDSEVPTPGCSGTASWAPTPNSVRNSSFSAANLLYMMKVESVPEDQRLGATPNEILVRGNTVGLRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIK2</accession>
    <name>M2YIK2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_57111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIK2"/>
    <dbReference type="STRING" id="675120.M2YIK2"/>
    <dbReference type="eggNOG" id="ENOG502R7TT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022381_2_1_1"/>
    <dbReference type="OMA" id="HRYELLT"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000004">
        <property type="entry name" value="Glycosyltransferase family 32 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="512"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME38741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="632" mass="69362" checksum="6B3C19D84CC83C48" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJJ6</accession>
    <name>M2YJJ6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_83665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJJ6"/>
    <dbReference type="STRING" id="675120.M2YJJ6"/>
    <dbReference type="eggNOG" id="ENOG502QV31">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_669067_0_0_1"/>
    <dbReference type="OrthoDB" id="3633611at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="51"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="411" mass="45957" checksum="7455C3E3E168A5C7" modified="2013-05-01" version="1">MADAAHECATGVGAAAVSHQIHGRLFEVPFDQLERRRPNPASRRVEVTIPYTALSYHWGDESDDIEYIVLHKSGSRFFQTVMEAQAAKKAKSAADLTKPQRSQPKENKYPVKINLYRALKALQHHQHTIVMWIDALCINQDDPVEKQAQLAKINLVYELAPKVLIWLGPADSAGQCSTHTDEMDTLLLSRAARGLDLSIRVQGFEVDTITWRTIGLSGGLVPKAVMVRLAPTFMNKVQEHYPCETADVPDNVWKCLVAERGAGGANPPPPTYPRACKDIMSNHLSGNDLNIRELLRNANVLDYEKEFLSRIEAVTCNRSYFEAGPELNDKEQVEDRLHGFGPEGLEVNDVVCILFGCTVPVILRPKTNTMTGNLQYYKLVGECYLYGLMDGEAVVLNEKYKGGSTREFRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2YMF9</accession>
    <name>M2YMF9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_25086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YMF9"/>
    <dbReference type="HOGENOM" id="CLU_1061842_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28102" checksum="D17826950744C8AF" modified="2013-05-01" version="1">MAQAIPQLHPNASNIASKGTAANPTPVAQIYLDRDLVDAKYVTSDGTLGESHSLPPTSEPRTGQYVTSLKGVNLYSVRGTRVASYLKSTNTVGPIEFIDCRGAPFELLTMKASNGAMKRAKHIPMLGGGEAEAALKKFKEKNPGGYSDLLKAKYVVVYCVVGQDRSPAMVLAYAAAWNQAAKNDKNCEQNVCLLNNGFKNGWKTGKGDDAVAFKLQTVTDPTFRANMGKASPTKTVIHLFFIACSLLILLHGNRVCPSLIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2YMP3</accession>
    <name>M2YMP3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_153605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.M2YMP3"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261362_0_0_1"/>
    <dbReference type="OMA" id="ITSQTWD"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF2">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G17620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004030074" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="846"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME43210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1302" mass="138525" checksum="13CDCBC649B84CDD" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2YPB0</accession>
    <name>M2YPB0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_25397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YPB0"/>
    <dbReference type="STRING" id="675120.M2YPB0"/>
    <dbReference type="eggNOG" id="ENOG502SSJN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_690824_0_0_1"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="399" mass="44781" checksum="D73E8D891B7BD427" modified="2013-05-01" version="1">MAASWLDYPFTLRQSTRIGNMFLVLQPSTIGIATSHLLKRDQASDVSAVASSIAASLSSPTFVPYVRPKQKIEDFIAIVDSFTAGTGSNGQGEVLAGDAVRGQRAYPMPMSTDESGWQFVNGGNVALPRFSFHTYTGDTTVQVVTEQLNSGDYKDDKGLPRHLERMRLFRLPDHRWTRLSAELKKLQDEIDSGILRNKINTALRHVASAGRQAGGADPRGSFQCDEIRWGFWPGRKPKLTTALHERLNDLTRSVSGEIKKAADDLEHMCVVYVDISNDKYNDHRFCEPDRTDQKMIDYDAWSWSWDSGIESPSEGPRDPNHAYDGESVNVAQQIYDFVFPDQARNVSEEADNAPAWAAEIDKRYPTMDDLFNAMENSRPALTMKYPLPYFDKAMLPLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBI2</accession>
    <name>N1PBI2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_48597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBI2"/>
    <dbReference type="HOGENOM" id="CLU_2867621_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="64" mass="7014" checksum="FB1416A28FC61519" modified="2013-06-26" version="1">MFVKEKCVREARCCCSKQPTAQSSSRCTCSLQRSSELKDSNPELPPVMPAALQRSASGLPELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCA4</accession>
    <name>N1PCA4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10 11">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 10 11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_137959</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 11">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 10 11"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCA4"/>
    <dbReference type="STRING" id="675120.N1PCA4"/>
    <dbReference type="eggNOG" id="ENOG502RXA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052631_0_0_1"/>
    <dbReference type="OMA" id="ISLYGWT"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109290" description="Endo-1,4-beta-xylanase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="13">
        <location>
            <begin position="40"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME39847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="229" mass="24624" checksum="01BFE845F3E97EE9" modified="2013-06-26" version="1">MLSMQPLFLIVTSILGALAAPVVEPFELVDDVNTTSLEARTTAQGTGTNNGYYYSFWSDNSQGSVTYNNGDAGSYTTQWSDVGDFVAGKGWNPGSARVINYSGSFSPSGNAYLSVYGWTTSPLVEYYILESYGTYNPGSGLTLKGQVTSDGGTYDIYETTRTNAPSISGTATFQQYWSIRTTKRVGGTVTTANHFAAWKKYSMALGTYNYQIVATEGYKSSGSSSITVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD85</accession>
    <name>N1PD85_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_116176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD85"/>
    <dbReference type="STRING" id="675120.N1PD85"/>
    <dbReference type="eggNOG" id="ENOG502QUDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068733_0_0_1"/>
    <dbReference type="OrthoDB" id="3550957at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108714" evidence="2">
        <location>
            <begin position="22"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="248" mass="25772" checksum="BF7562C2AE4A112F" modified="2013-06-26" version="1" fragment="single">YHHALMLIAIVAIACASVLLAGCHPTAGSLQNVYLLSIEYATTANEAAGVSTRIANSNDVSTAQIAVRAGYFGICARNAAHGAWRCGSAFALRAVLGVGRNDTLGAIATASSFRSHVVFPGLIIGGIASLALCWAGLATTPGWHEEHDEQTGSTIDVKPFPSRPVSHICLLLSLLSTVFFLVSALWQHISAATCASLVASVTEDRLQGSVGGVSAALCWMAFALAALLFAGVLVVILSLRLLDKLTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDR1</accession>
    <name>N1PDR1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_136506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDR1"/>
    <dbReference type="STRING" id="675120.N1PDR1"/>
    <dbReference type="eggNOG" id="ENOG502SKKQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093259_1_0_1"/>
    <dbReference type="OMA" id="GYLQWAD"/>
    <dbReference type="OrthoDB" id="3626489at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="198" mass="22026" checksum="D02DF23F65006BD7" modified="2013-06-26" version="1" fragment="single">QHHLWKADLGYLIHPSIPVPAKPRIADVACGNGCWLLDVASTLQLPYALRGFDISLDQVPSTGLDPSAFPSVRFLTWNIFNDPPSDYVGAFDIVHIRLITVIFRDNDPIPVIESLKKLLKPGGYLQWEEVDNVDFSVLTPRGGEEAPALEQAVAQLCSSGKGDWKQHGAQFLNQNGFAHAKQFHIEPSNLNARFWTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE03</accession>
    <name>N1PE03_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM5</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM5</name>
        <name evidence="7" type="ORF">DOTSEDRAFT_159137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE03"/>
    <dbReference type="STRING" id="675120.N1PE03"/>
    <dbReference type="eggNOG" id="KOG3350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074410_1_0_1"/>
    <dbReference type="OMA" id="CNFRPEH"/>
    <dbReference type="OrthoDB" id="206354at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME40334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="243" mass="27334" checksum="7F7C615EB90B6C2B" modified="2013-06-26" version="1">MDDDDDIPQLSADTLAVLQEFNLEKDAKAKKFEDLKAQAEADFEGAAENGKLSMDLFGEDWNASQFWYTDATALLLARQLLQDATSDSAIAVVSAPSVYVALRNVLAEDTSLPRPKLCLLEFDQRFEVVGPDFQFYDFQQPLRLPAELKGRFDRIIADPPFLSTDCQTKTALTVRYLAKKGSAEGADGLRFISCTGERMEETISKLYGKVGTKTTTFEPEHSKGLSNEFFCYANFECEDWNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE13</accession>
    <name>N1PE13_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE13"/>
    <dbReference type="STRING" id="675120.N1PE13"/>
    <dbReference type="eggNOG" id="ENOG502SDMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102617_2_0_1"/>
    <dbReference type="OMA" id="RSHDNHA"/>
    <dbReference type="OrthoDB" id="2348401at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2440">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002590">
        <property type="entry name" value="HSP9/HSP12_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="83" mass="8660" checksum="29F632445B085471" modified="2013-06-26" version="1">MTDSGRKDLSDKVGDKMTPDSSKSTLDKVGEGLSGAGDKAARDLVPDSQKSTGQSLSDKASRSKDDAKNESLLDKAKDAVGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEV9</accession>
    <name>N1PEV9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_55062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEV9"/>
    <dbReference type="STRING" id="675120.N1PEV9"/>
    <dbReference type="eggNOG" id="KOG0140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1315392_0_0_1"/>
    <dbReference type="OMA" id="EMYAVET"/>
    <dbReference type="OrthoDB" id="10016597at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22943" checksum="1B2DB165053719FD" modified="2013-06-26" version="1">MIDFTLSRSQQQIHSEAAGFADQVLKGAGEIHSKHVSRSERFKVIRQFYRMAIAGGMIEEQIPTAYWRRRLPADTSVALTIAATGLGLTPLILSGNETFQKEHLKPLLSGEGEPLASLMHSEPGVTTNWLERDGKGYGRRTAAARTGKKADLQCIVCYEIPHDQPNAKPQNANPRSFTIILLLTRSVTAHDPFISSSAALTFALTFAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEW3</accession>
    <name>N1PEW3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEW3"/>
    <dbReference type="STRING" id="675120.N1PEW3"/>
    <dbReference type="eggNOG" id="ENOG502S2YE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_3_1"/>
    <dbReference type="OMA" id="KGVGHWH"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="239" mass="25519" checksum="EBF3FF2A2E6120DA" modified="2013-06-26" version="1">MIHGLGSSQNYYVPVIGQPELEGHHCLALSTYGAAQSRSQGENLTLEQLADDVVAMMDHVKIRRAIIAGHSMGGSMAFTIAAKCPDRVAGVVGIGPVNPASVNPAVFRGRIDAVNKNGMEPLANSVPQAATNARSTPLQKAFIRELIMNQDPKAYASHCEVIVNMKDPGFELIKAPSLILAGDEDKSAPMEGCQYIQSHLGSQQKELKVLKGVGHWHCIEAPEQVAKEIAAFASKITDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEX3</accession>
    <name>N1PEX3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEX3"/>
    <dbReference type="eggNOG" id="ENOG502SPD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117282_0_0_1"/>
    <dbReference type="OMA" id="TANCTYI"/>
    <dbReference type="OrthoDB" id="5352317at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109680" description="Small secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="13884" checksum="F1805A0617ACB604" modified="2013-06-26" version="1">MQYTTILALLTAVAAPAFAAPAGAPAITTWTLRDFTRTCADVCTYDYTIVAGQDATPCQYTAAGPEASYNGVQCGAFTISSNWSGQFGPGQGFQTLAVVSEQQIIYPGYSDAELVDGQAVVPDKSYRPQPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFJ2</accession>
    <name>N1PFJ2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NCT transcriptional regulatory complex subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Negative cofactor 2 B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_64704</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms the NCT transcriptional regulatory complex with nctA and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFJ2"/>
    <dbReference type="STRING" id="675120.N1PFJ2"/>
    <dbReference type="eggNOG" id="KOG0871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066247_11_3_1"/>
    <dbReference type="OMA" id="RDAKFKK"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017055">
        <property type="term" value="P:negative regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="13"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME41378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="148" mass="16376" checksum="C88A55BF44AB8929" modified="2013-06-26" version="1">MSDKEFGGNDDLSLPKATVQKIINEVLATNPAFEGANLAFAKDTRDILIECCVEFITMLTSEANEIAEKDAKKTIACEHITKAIADLGYPEFVPELEKVAAEFKTQQAHRERKQTKIEQSGMSHEELLKAQEELFKSAGDKYNAGPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFP8</accession>
    <name>N1PFP8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_46806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFP8"/>
    <dbReference type="HOGENOM" id="CLU_2427018_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="91" mass="10343" checksum="7C739E9C5D26073D" modified="2013-06-26" version="1">MSSAHPDLTPHFGRYDAEKQAEYDLTPTPYLFDFQHVSEYGFKLPQSRQTIGGSSQDGPNTSRVRTGRKQEIQHDFRYLSTIGFTTLVMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGD5</accession>
    <name>N1PGD5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_36842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGD5"/>
    <dbReference type="STRING" id="675120.N1PGD5"/>
    <dbReference type="eggNOG" id="ENOG502QRAQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049915_0_0_1"/>
    <dbReference type="OMA" id="GLWFFNS"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="182"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="284" mass="31621" checksum="FEA06DB551C9874D" modified="2013-06-26" version="1">MDATPLERRALQNFDDLLEREQLFWKDTQPQVVKSSPFDFEFRVAPSFKSKPVLPADAKGRSEDTGAFGDDDPAFTIESGISHKLILNKFCVVRPQFVLHTTEFEQQSDPLTHRDIEALWQTMQSLGQGKYIGIFNCGAKAGSSIGHKHMQVFPRSDHTIFPDSLVSQHRIDGTAIIPLRHPEVSYEHAVLPNAQTASADAIFRSYENLRHTLQLEQDSPHNAIITGTSITVIPRTQANVGPRAVNAAGMLGMVWVKTGDELEAWKEYGPAKVLKEVGVQHSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGL4</accession>
    <name>N1PGL4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">squalene synthase</fullName>
            <ecNumber evidence="4">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">sqs1</name>
        <name evidence="18" type="ORF">DOTSEDRAFT_36908</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Squalene synthase; part of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a heavily oxidized fungal polyketide that offers potent cholesterol lowering activity by targeting squalene synthase (SS). Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. The presence of a gene encoding a squalene synthase supports the identification of the cluster as being responsible for SQS1 production and suggests a likely mechanism for self-resistance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGL4"/>
    <dbReference type="STRING" id="675120.N1PGL4"/>
    <dbReference type="eggNOG" id="KOG1459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031981_2_1_1"/>
    <dbReference type="OMA" id="CKSEESF"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00053206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME41522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="407" mass="46802" checksum="0F2051F6C8B18597" modified="2013-06-26" version="1">MAPSMSHYLTHPAELRAMLQWKLLHAPIYRSDETPGTQTHDLKECWRFLALTSRSFVAVIQQLHPELLMPMCIFYLALRSLDTIEDDMTLPIAVKEPLLRDFDQHLDDETWTFDGSGPDEKDREVLVKFDCVAREYNKLKEEYRRIIADITKRMGAGMADYAVTADTVGVKTIADYELYCHYVAGLVGEGVTRMFVLASLAEPRVMEKPELAEAMAQLLQQTNIIRDVHEDHMDNRHFWPTEVWSKHVDKFSDLFQKDPPGQRKALECMSEMVLMALEKAPDCLSYMANVREQSVFNFVAIPQTMAMATLELCFQNPSVFDRNIKITRGVACQLLIDSVKDLRYVGRAFSRYAAKIQKKNRPEDPNYSKIDAACTAITQSTHRLLLDYKPPPTLRAQHLWLSPHSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGW0</accession>
    <name>N1PGW0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_26758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGW0"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_891434_0_0_1"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME41607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="312" mass="35631" checksum="F4F5450A4C84272B" modified="2013-06-26" version="1">MAFGLQTLRASRHAMWHVLAPQMWKVNSRKPRKAPKCREPPQNPSQRCAAPVVLLHSVPDVAFDSNSEPLTAVKPICPSGAGSRCSDAHRAGVVGSSDCTIIVPRPCGDEGVSRQFAAELREDLAKQDNGWVPYASGESYRHICRYQGGFFYRPQLALEYEWYWRVEPHIQLFCDLPNDPFRYMAENHRKYGFAISMNEISRTVPILRTHVRAVVRDFPQHLSKVNHLAFLSEDGSVTTKYYRLWSRFELVRLEWFRSEAYADIFNYLDVAGGFFCERWGDASVLSIVPYSLRSLMAPVSRDGRHARSTCPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHU5</accession>
    <name>N1PHU5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Catalase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_54448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME41957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHU5"/>
    <dbReference type="STRING" id="675120.N1PHU5"/>
    <dbReference type="eggNOG" id="ENOG502SI2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046417_2_0_1"/>
    <dbReference type="OMA" id="NTRENAK"/>
    <dbReference type="OrthoDB" id="3358373at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08152">
        <property type="entry name" value="y4iL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF4">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="44178" checksum="71CF0C6EF3FA6332" modified="2013-06-26" version="1">MGSIEQEKYIRWDAKGVEYEQEGELDKIWEVSKQFNRLQMMNFNEHMHCLRGTHLKTQGCVIGRFKVNDHLPAHLAQGMFAKGGTYDCIMRYSSLTPKILPDNVPQPRGIGIKVFGVEGEKIWGEDKKTQDFTFNNYPVLELRTPVATCEIADSLERNWNTLDKFGEELSARPDADVATLPARLDRQHLVAMKEWSQSAYRYGDYVAKFGVFPKGEAQKKIEKEYLKDDDPINILSQHARAFHQNHKVTYSFCVQLLENLDDQPVEDIGVEWDEKKYPFHEVAELEFDPQDSWLPEFRVWWDDRITVNGWHGLKSHQPLGSTNRMRRVVYAESRKLRLRVNAHKDYIEPESLTDVPAPIPAIQLPYNPKSGQKAVTSVEISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHW7</accession>
    <name>N1PHW7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_74464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PHW7"/>
    <dbReference type="eggNOG" id="KOG3572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000935_1_1_1"/>
    <dbReference type="OMA" id="RTWHFKR"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="6">
        <location>
            <begin position="1007"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="567"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="925"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1107"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1349"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1402"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="928"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME40916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1447" mass="160518" checksum="63DA5E708B4AE548" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJV4</accession>
    <name>N1PJV4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_73483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJV4"/>
    <dbReference type="STRING" id="675120.N1PJV4"/>
    <dbReference type="eggNOG" id="KOG1230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012508_0_0_1"/>
    <dbReference type="OMA" id="ATFTQMN"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="645"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="533"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="703"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="740"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME42672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="804" mass="85382" checksum="2772A2F2FF5AEC2A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK15</accession>
    <name>N1PK15_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_23979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK15"/>
    <dbReference type="STRING" id="675120.N1PK15"/>
    <dbReference type="eggNOG" id="ENOG502SM9J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060136_1_0_1"/>
    <dbReference type="OrthoDB" id="4391601at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008684">
        <property type="term" value="F:2-oxopent-4-enoate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050772">
        <property type="entry name" value="Hydratase-Decarb/MhpD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30143:SF0">
        <property type="entry name" value="2-KETO-4-PENTENOATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30143">
        <property type="entry name" value="ACID HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31038" checksum="1E4CCF4B9E6580B6" modified="2013-06-26" version="1">MTSPSPSSVDQPYTTSQASHASSLCTSHWQNGTTLTSLPPSLIPPTIAAAYTAQSHITSLSSHPLWGWKIAATSIHGQKHINVDRPLAGRILRERVTPYGSPVPLGANRMLVAELEFVFRMGETLEPRDGGEGEGKGEGGYRQEEVMEAVDGLWLGSEIPDSRFEGFVTVGAEQLIADNACADRFVLGPEVTVAWRDVDLAEHAVKGWVVDENGEVGEVREGKGGNVLEDPRIAMTWIANELSRYGVPLEKGQYVTTGTCIVPLTIKPGVRAVLDYGGLGRMELEFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK45</accession>
    <name>N1PK45_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK45"/>
    <dbReference type="HOGENOM" id="CLU_1447647_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="187" mass="20990" checksum="DFE29102BCAC1E84" modified="2013-06-26" version="1">MDAHARHRFATLQAGLYYDSAAGIHVTAHIIKGLHSPDLMGLRWGKPGQGLPSWVPDFSVAPAPLPDFPVPRELASLVNRASSSHSSLHIERLRRQTWSPRTAGFLDNVASVCSCEPFKDLDNRVRAFHRDAEAWLAKFQDEAALLASMETMVSTEDKELLTVRRQALRRRRARYGRNSADLKAELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKG1</accession>
    <name>N1PKG1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C6 zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tfc9</name>
        <name evidence="6" type="ORF">DOTSEDRAFT_53115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKG1"/>
    <dbReference type="STRING" id="675120.N1PKG1"/>
    <dbReference type="eggNOG" id="ENOG502RJK6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004083_7_1_1"/>
    <dbReference type="OMA" id="WPNVWDA"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME43831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="686" mass="75461" checksum="F7294473104F8D45" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKJ2</accession>
    <name>N1PKJ2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_135377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKJ2"/>
    <dbReference type="STRING" id="675120.N1PKJ2"/>
    <dbReference type="HOGENOM" id="CLU_054243_5_0_1"/>
    <dbReference type="OrthoDB" id="3633414at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="180" mass="19895" checksum="043CECAFE2E5E10E" modified="2013-06-26" version="1">MVDQVDVAPNGDLVLIIRDELALRVYSVILELCSPVFKAMLDPHFAEGQIQGASADPKRIALPEDSAEGMRILCLCLHHQTDTLKQLPSHAVIQELAIVADKYGCMNAVCSVLESWLAQIDTLSWKNPGPVLHTICLFDDAERFQTLTEDLNGGVAYSPSERGLRLRTRRCSVSVVIEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKN7</accession>
    <name>N1PKN7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_36050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKN7"/>
    <dbReference type="HOGENOM" id="CLU_625594_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="438" mass="49255" checksum="D9D1A1FDB443191C" modified="2013-06-26" version="1">MLLWPASIAKASKLRVSMVMFGTYFSRYREHKHAEANGYRWRHGRRRSIVNNVLFSLCLFFMAASDISRDVHLDLTEVNGGMEDDESQHDDENPLCTCFARALRPLDILHRESRLFIQHEVEHNVEGDREAKDAVIDGLLSTSWNSDALPDLAKWRDLTKKAQVCSKLYNSSGPYFIDEERGQGPNTQVDYRTLPTLCCNDSFKRGTLSPASTLPASVVSAVSAISASLFLPALHLQIFRITTPSTTKARIAVHKATTAVRFMPSNTKLEASSTKPRYTMNTIWKPSVNNVPIPNCLISSHGQALHRQRLVICLRLVIRLLLVVRFIFALCTHEPVSQKHYTTSKCRDSEEGQEPSLEEKEPFQEEGANGDDEAKNSAEEGDKAVEAEGVTVGVTAVVVLERDILMRKAVACRQRYGFVDVQVQMTQRQYRGGHRHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKP7</accession>
    <name>N1PKP7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKP7"/>
    <dbReference type="HOGENOM" id="CLU_1948775_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="129" mass="14211" checksum="DCF5CDE1E5530F44" modified="2013-06-26" version="1">MSSSRSSSGSVMALQRTRTIRQRSMSSGTRPEYRATRGGTMYGGASRSSANRRLSRMESGWKVPTDHVSCEYLAICASMQQRCRQESGRSGISKMLSRNLAGSGTLSGRCSHDVQSKQRSDQPATRQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKY1</accession>
    <name>N1PKY1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_71724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PKY1"/>
    <dbReference type="eggNOG" id="ENOG502QPI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000998_2_1_1"/>
    <dbReference type="OMA" id="FCVIREY"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="826"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1274"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1476"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1573"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1374"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1477"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1510"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1536"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1573"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1618"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1646"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1693"/>
            <end position="1704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1722" mass="190193" checksum="0A91B1A04A39DBFF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL16</accession>
    <name>N1PL16_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PhzF family phenazine biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL16"/>
    <dbReference type="STRING" id="675120.N1PL16"/>
    <dbReference type="eggNOG" id="KOG3033">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153351_0_0_1"/>
    <dbReference type="OMA" id="MTHFEIT"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF32">
        <property type="entry name" value="ANTISENSE-ENHANCING SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15293" checksum="6EDC82C9648AE5A1" modified="2013-06-26" version="1">MNFITVELPDLESLAKVTSSSKPAPKLDEYDGWNVGFSGSYFYVLAEPGLDTSKVNLQSRMIEGSFEDPATGSAACALTCYLALKRAKHRMTHFEITQGLEMGRRSEIGVTITLTKDLKSVERVELSGSAVKVTEGQIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL26</accession>
    <name>N1PL26_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_24145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL26"/>
    <dbReference type="HOGENOM" id="CLU_1396285_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="24"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="195" mass="22647" checksum="39930DC0571DCA52" modified="2013-06-26" version="1">MDGSPTRHSFSQRSDFRVLEGQVKQYKHGTKMVIEWLSNTMKATFDLARAQALVQDTTEELTTTNCHGISDLATLVRESCKRTGRRPSIHAIVMNIKRKDSVIFQRFQVTQYIPEAERDAEHQHFIEVIKSVRAELEKARMLLDESMKLRAKPHIRGPVVERRGSNYYEYLPREPTPPSSPREQHEEDRGREEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL45</accession>
    <name>N1PL45_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_54681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL45"/>
    <dbReference type="eggNOG" id="ENOG502T9AX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1194865_0_0_1"/>
    <dbReference type="OrthoDB" id="3646160at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25600" checksum="DD89C7C2C1CA66EA" modified="2013-06-26" version="1">MGNVSSRGEHPFSFLHLPPELRNEVYRHSLTHDRRKGHKATPALLRTCKQIYDEGISILNAESTLSVTVSVRPWSSEITLTGDFHRERQSESIAHTLPLRLTNIRNLQLHLKHAPLYGRGAYTNAGSASAIHDFLTQLTASLRQSTLPRTITCALEIEPPNCSAPGPSRIQDPRVEEMLTPLFPWPATASVRVESRAPSILGVLGWLASGNGWLARSAARSITTCTLEAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM75</accession>
    <name>N1PM75_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_72061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM75"/>
    <dbReference type="STRING" id="675120.N1PM75"/>
    <dbReference type="eggNOG" id="KOG1465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_4_3_1"/>
    <dbReference type="OMA" id="SHSCAVA"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000008">
        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME44456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="490" mass="52997" checksum="C89D00F11B659601" modified="2013-06-26" version="1">MPAPAVGTRPSLRTFLYNLKHSDNVESSIALLVSLLKFRQIAHSRPCAIATTRLLLQVVAARRWSSSKDLERRIREVGERLQAAQPREMAVGNIVRRVLGIVHEVAEDDQDTTSTNDSQELPASPAVNTGVSTHRPKLPTNISEFSPLHQGAALPHSAQPHASSAASSPSINGTTESPPRRPALTAVASSYAGQGPHGSLFGILTQPQGLASIGGSPPDSGTTTPVPKSAKNQDESKEKLDIKAEVIDGIKDLLEELDIVDSQISEYALDHIHSNEIILTHTSSQTVQRFLSAAARKRKFTVIHAEAYPNNHEETHSTVINGSQKAGEDEDPNERWKTLTSMGIKVIVIPDSAVFALMSRVNKVIMAPHAVLANGSLIAAAGASTIAQAAKAHQVPVVVLSGVYKLSPVYPFDMSEMIEYGDPGKVVPFQDGPFMDKVDVINPLFDWVDADLVNLYITNLGAHAPSYLYRIVADHYRTEDIDLTAKVQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMM7</accession>
    <name>N1PMM7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_172955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMM7"/>
    <dbReference type="STRING" id="675120.N1PMM7"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_59_8_1"/>
    <dbReference type="OMA" id="ACIKKAC"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME44657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="565" mass="62443" checksum="BBFE5A1675FB94A7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMU0</accession>
    <name>N1PMU0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_36575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMU0"/>
    <dbReference type="HOGENOM" id="CLU_1384140_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="197" mass="21682" checksum="3538FA4AC77D576C" modified="2013-06-26" version="1">MANTFGTDTASQKDNQHMYDDDTSGSDGETEGYIPFSDERLEQEFKAALSGGDESLSDDETSSATADPVDTAAVIPTPVPAITLAIPSTPMASSSHSIRSACDCRIETAAEGERCTHSFYDHSPRWERDRQEEKPWNGVLEAEKTVFRPGLFKAEYPQGTILGWHKTDEEAMRVVQEVMMREAQETQGAKDRGTLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN20</accession>
    <name>N1PN20_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_88843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN20"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="OMA" id="GSWMALT"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF230">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="69"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME44826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="466" mass="50738" checksum="151B0A0C6F463E67" modified="2013-06-26" version="1">MLRERTLYSEPTFDSALAMQLKCHRRLNRVRGPSAIIIANATGRNKRPTSKGVDLRARWENISESMTTAAWIVLAGSFLALFPSFGLIVSIGTLQDYWQYHQLAGFSSRDIGWISGVFTYLALALGICCGPVFDRHGPRVVMLVGSIAYIVAIFLLAECKLYWQFMLCLGLLAGPAAAALTTVGLAVVSHWFKVKRGFASGIAMVGNSFGGVVIPLVLRHCFPRYGYAWSIRILGFVFTVCLIMSNFLVRSRFPPSPDAKKSKIFSLDLFGNGAFSFLTVSVLGIEVVLFGSLGILPTYAGLSTDYPAATGFYLIAVMNGSSCFGRILPGFISDYVGRFNTLLVMMVFTLVVMLAIWLPFGTSSLAALYAFTALFGFGTGSWMAMVPATIATLSGPHHFGQYFGTSYFVASLATLVCIPISGELIQSVGPKALVGFMCAMLFVSIFTFAASRWFLLGRVWKWSAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN54</accession>
    <name>N1PN54_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_71600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN54"/>
    <dbReference type="STRING" id="675120.N1PN54"/>
    <dbReference type="eggNOG" id="KOG0120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021795_2_0_1"/>
    <dbReference type="OMA" id="MTQWDIK"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="105"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="227"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="334"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME43820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="433" mass="47313" checksum="B588C24D1FCEDA40" modified="2013-06-26" version="1">MRQLERQTARKSASPPPRKPKEPTPDLTEVTSVLERKRRLTQWDIKPPGYENVTAEQAKLSGMFPLPGAPRQQPMDPQKLQAFMNQPGGEANKTALKPSTARQSKRLLIYNIPASATEDTIMDFFNLQLNGLNVTRGADPCISAQLSQDKAYALLEFKTPEDATNAMAFDGINMEPEAMVTSGNEDENGGARGLDIKRPKDYIVPVVTDGTENDAGVLSNVVPDTQNKISITNIPAYVDEEQTMELLNSFGELKNFVLVKDASTEESRGIAFCEYKDPNSTKVAVESLHGMTLGDAAMKVRLASIGIQQVSGEMSVNAMSLMAGTARADGEGGRVLSLMNMITPEELMDPDEADEILEDVKEECAKYGPLLDVKMPRPTGGSRQSNGIGKIYLKYESTESAAKALAALAGRKFADRTVVVTYFGEEYFDVNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNC8</accession>
    <name>N1PNC8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_110190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNC8"/>
    <dbReference type="eggNOG" id="ENOG502QWCE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1431213_0_0_1"/>
    <dbReference type="OrthoDB" id="3189033at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="190" mass="21521" checksum="26CD95408246B7AD" modified="2013-06-26" version="1" fragment="single">DELLRENFTASLLRTKKRALRDTLISALLFPPAIVLDTLAVPIWPFGGLAEIDAVWLYASIRGLKTSHTITKRLSLSSSSSPSSSKKSDQLTLTLTPFPKMPVLEQYLSARCHDADPKLFPEYVAPPPDTDVLKAMGWEHRGGGGRGWEDRQWESQQVKDDLERCFGKAAKEWTRWCKRWVKDPEKAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNN0</accession>
    <name>N1PNN0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTF2-related export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_71711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNN0"/>
    <dbReference type="STRING" id="675120.N1PNN0"/>
    <dbReference type="HOGENOM" id="CLU_1855236_0_0_1"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="138" mass="15006" checksum="408A56F4483A099C" modified="2013-06-26" version="1">MADPAATATPFLERYFTTFDFGSRATLEGFYTSSSRLTFEDTTCTGASEIVPFLFEAPKQLEHKRAKTVVDEIGSGGNLSVLVTGLLEFGKRGTTSKFATSLVLGRKEGGTDGEERWVILSQIISISFDGSEEVDMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNR6</accession>
    <name>N1PNR6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_71733</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNR6"/>
    <dbReference type="STRING" id="675120.N1PNR6"/>
    <dbReference type="eggNOG" id="KOG0881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_1"/>
    <dbReference type="OMA" id="PYHKANF"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="45"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME44030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="193" mass="20157" checksum="4B75978C8335623F" modified="2013-06-26" version="1">MDKLKKLFGGDKHAEQSASTASSSATPAASSGTGNADKPNNVVLHTTIGDITCTMYSEQTPRTCKNFATLAQTGKYDGVIFHRIIKNFMIQGGDPTGTGRGGSSIYGAKFEDEFVSSLKHDGKGVLSMANAGPGTNGSQFFITLAATPHLNGKHTVFGRVTDGMDVVDKLGAVATDAGDRPKSEVKIVNTTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNS5</accession>
    <name>N1PNS5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_61650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNS5"/>
    <dbReference type="eggNOG" id="ENOG502SA4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111658_1_0_1"/>
    <dbReference type="OMA" id="YEFPLRT"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048269">
        <property type="entry name" value="RNase_U2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037430">
        <property type="entry name" value="RNase_U2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109997" description="ribonuclease T1" evidence="10">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME45057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="132" mass="14188" checksum="18944C0494B0BCA8" modified="2013-06-26" version="1">MRFAFASAVLFAVSAIAAPTSEFVKRQSSTTCGNNYYSYDQVNDALNQGYNYYENDQQVGNDGYPHQYNNYEGFSFPVSGPYEEFPITESGVYTGGSPGADRVVFNTNGEYAGAITHTGASGNNFVGCSGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP25</accession>
    <name>N1PP25_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_23221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP25"/>
    <dbReference type="STRING" id="675120.N1PP25"/>
    <dbReference type="eggNOG" id="ENOG502SBGS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012883_0_0_1"/>
    <dbReference type="OMA" id="VCRKQIR"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="875"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="846"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="936" mass="104371" checksum="028CF03FFACE5D87" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPI7</accession>
    <name>N1PPI7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_70793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPI7"/>
    <dbReference type="STRING" id="675120.N1PPI7"/>
    <dbReference type="eggNOG" id="ENOG502SKCU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011237_1_0_1"/>
    <dbReference type="OMA" id="DNGWSTI"/>
    <dbReference type="OrthoDB" id="5420905at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="875" mass="99373" checksum="359FA69C5B9433C9" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ48</accession>
    <name>N1PQ48_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_72118</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ48"/>
    <dbReference type="STRING" id="675120.N1PQ48"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012630_2_1_1"/>
    <dbReference type="OMA" id="EMIYKEM"/>
    <dbReference type="OrthoDB" id="1908178at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="489"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME44549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="78327" checksum="5A7CEE789C45CC23" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ87</accession>
    <name>N1PQ87_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_70967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ87"/>
    <dbReference type="STRING" id="675120.N1PQ87"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_4_1"/>
    <dbReference type="OMA" id="NWYRVRT"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="42"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="395" mass="44911" checksum="E136FD755FB2F8AC" modified="2013-06-26" version="1">MSQANSLDPLPLPQGVIEDYADCTSSCGLDFHLLKAGTPGNPLVLFCHGYPELAYSWRKLMPKVAAAGYYCVAMDQRGYGRTTGWEDKPYDLVDLTQYTMTNLVRDLVCLVYKLGYTEVTCIIGHDFGAVSSAMAALIRPDIFKATIQMSHPHHAPPTPQFSDQAQKPKLDIQAELAKLNPPRKHYKWYNSSPGAAEDWNSPPQGLEKYLRGYFHLKSADWDKNDPHPLQAWSAKDIEIMPEYYVMKKDDTFPQTVEKNMQSEDYSKTEKWLPPDDLKVYVKEWQRVGFQGALNWYRAQTASTPQSKKDMFLYSGRRIDVPCMFISGKQDWGNYQQPGAFQAYEDGKCVKAGCFKGARLIDHAGHWVQQEQPEATTKEVLQFLRGLETYPLSGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQE2</accession>
    <name>N1PQE2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_88720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQE2"/>
    <dbReference type="STRING" id="675120.N1PQE2"/>
    <dbReference type="eggNOG" id="ENOG502RXXJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080487_0_0_1"/>
    <dbReference type="OMA" id="LEYIHIC"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="222" mass="24435" checksum="4D8FF8C8486ED9FF" modified="2013-06-26" version="1">MASTGHKRKHTFIVEHLDPELEDWQALEYDCISNEATDAGSVFLLSGLSSDFSSLGKLHVPATSKTQQSVESIYATPIERQRVCLLDPKAEKDLSPDDGELFDAFLFGGILGDDPPRDRTGDLRKLGFPGRRLGPEQMTTDTAVRTTRIVVQESKKLEEIEYVDRPDFDVPSRPKADGKAGPTETVSMPFKYVKGTDGQPILPEGMLALLASDADKDILDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQI4</accession>
    <name>N1PQI4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_34170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQI4"/>
    <dbReference type="HOGENOM" id="CLU_1777389_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="146" mass="15891" checksum="48166EC6339C6AFC" modified="2013-06-26" version="1">MSADFNEGLSQQCILDGTMYDDVADWRRQVNVVRAGIVDVHRDAHKTVQDKLLEARGHLEDELRQRGSLNHVTCAEADVVETDFQTDVEIDGIELQPQATAQANELQEQGTRGGQQPQSAAVTSPDSGNPPQVGASGERHSPGPYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQK8</accession>
    <name>N1PQK8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_128553</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQK8"/>
    <dbReference type="STRING" id="675120.N1PQK8"/>
    <dbReference type="eggNOG" id="KOG1578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_3_1_1"/>
    <dbReference type="OMA" id="NVAWAHE"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME45736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="216" mass="24048" checksum="A29B7DC51B5C87CB" modified="2013-06-26" version="1">MTSPPDHSTFFAHLLDNNKTWATKTATDDPSLFPSCAKGQSPRMLYLGCADSRVPETTILGCKPGEVFTHRNIANIVSNTDVSLLSIVQFAVFHLKVTDIVVCGHTSCGGVAASLENAKLDILDVWLQPLRLLRERFSEEMEGMEVERVKKCLCEKNVLAGMENLERIPTVIDAVRERGLQIHGVIYDVATGLLEEIVYEEDEVVGKRRMAAFERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQQ0</accession>
    <name>N1PQQ0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_71095</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the CWC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQQ0"/>
    <dbReference type="STRING" id="675120.N1PQQ0"/>
    <dbReference type="eggNOG" id="KOG1813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050460_0_0_1"/>
    <dbReference type="OMA" id="ANFRKKP"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="234"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME45273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="318" mass="35135" checksum="0FE1F383BE5716AC" modified="2013-06-26" version="1">MADVAAPIFKKRANKGSNVRKRPASPAAEESGPDSDYTDDEAGVRIKRRKKEGVTLGTGPKREVDFSKTTNFEADRSKTIADHEDATKASNWYTDAALAAKDAPSPAAGRTETVVPDATDGKYQGTAKYSTFIQKHPDHEKKVGPVKAPTNVRAITVTDFAPDVCKDYKQTGFCGFGDSCKFLHAREDYKQGWQLDKEWEKVGSKKDKLGQTGKEDTSGMTEEEKMLLEIPFACIICKESYKNPVVTKCGHYFCEKCAMGRYMKEKRKTCANCGADTGGSFGVAKKLKGLLEKKKQREEEQKEKEENEGDDDAKVNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQS2</accession>
    <name>N1PQS2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_170605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQS2"/>
    <dbReference type="STRING" id="675120.N1PQS2"/>
    <dbReference type="eggNOG" id="ENOG502S0YM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071343_1_0_1"/>
    <dbReference type="OMA" id="FPMQGGL"/>
    <dbReference type="OrthoDB" id="2131401at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME45293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16189" checksum="1DF0A298295A60C5" modified="2013-06-26" version="1">MSHRFLKLQVNPKPLSYEVPPYPSLYWPFPVDGPQNNYLYDAEPIWRFTLYWTLVCVGGIHLIAGAYACAIQRRNWKLIWITPIIYTIIGTTEALIAGNAVGALRLAAVYTAGFFRMSTWIPLTWGVINALVLILSSFAIQGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR73</accession>
    <name>N1PR73_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_70836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR73"/>
    <dbReference type="STRING" id="675120.N1PR73"/>
    <dbReference type="eggNOG" id="ENOG502SFGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076914_0_0_1"/>
    <dbReference type="OMA" id="HPEYFSP"/>
    <dbReference type="OrthoDB" id="333176at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="138"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="213" mass="24509" checksum="30D594120C7050CA" modified="2013-06-26" version="1">MPHFPSSDSMVASEALSTLSIHSKHENMSATGQVQPDRIRIKNRRKRYLDLHPEYFHGAELELADPLLYDRLVRRYQSADEREKEGRQRGYTGVLEADLVRSEAKIDALKHPDPNSPIVYKRDGRGSIYSVDQDAEDRAMSRDEGWARWIDVMGQRFLRGDDGDFDYAAVDDSDDFDDREEEDRSRLEQYFQGEEAQFVGDGKPTGETGIQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR86</accession>
    <name>N1PR86_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_70055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR86"/>
    <dbReference type="STRING" id="675120.N1PR86"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_0_1"/>
    <dbReference type="OMA" id="GHDSCSQ"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="503"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="852"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1068"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="930"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="934"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="968"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="988"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1013"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME45902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1256" mass="141545" checksum="9961930FF1B53EE0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRP0</accession>
    <name>N1PRP0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_60757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRP0"/>
    <dbReference type="STRING" id="675120.N1PRP0"/>
    <dbReference type="eggNOG" id="KOG4419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_7_2_1"/>
    <dbReference type="OMA" id="WLATINS"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="6">
        <location>
            <begin position="307"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="555"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME46057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="660" mass="73399" checksum="C1B31E50C5D87B89" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRR4</accession>
    <name>N1PRR4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRR4"/>
    <dbReference type="STRING" id="675120.N1PRR4"/>
    <dbReference type="eggNOG" id="ENOG502SKZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024203_0_0_1"/>
    <dbReference type="OMA" id="FGEAMHW"/>
    <dbReference type="OrthoDB" id="5413829at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2790">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="352" mass="38276" checksum="72D410EC047F9EFE" modified="2013-06-26" version="1">MAAPIVVTPSAGSVEPKSSHVLDPTIQPFLHANFDPAAYLNNTLPGLSISSTSSRAGRNVSLPDLSLQLQALLSQLNAHTSRLSSTLTQLTDEIIRSGSRLAYEVEVLKGETLGLTDTFNNGLNKEISLLAPGESMVKQPNAAAQSKNCMEALKVNGTDGDDERSQPAEPDFLQRLRTLTTVRERLDTVIKTFGSAMQWPLAPSELSIASSFISVSAPEGTDDSRSREEKGKQHVEKLRNEVNELVSSGAEGLRTANERVEELRLLAEVWKGTAEEKARFKLVDALQKAIDDKQKTVAKTTAEGNRKPGVSPARGYDHRYGDTDTTQVTGEIGSGYGFLQNLRNLKNELYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS12</accession>
    <name>N1PS12_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_86785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS12"/>
    <dbReference type="STRING" id="675120.N1PS12"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_4_1"/>
    <dbReference type="OMA" id="FHNMGSQ"/>
    <dbReference type="OrthoDB" id="4050368at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="198"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME46162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="636" mass="69842" checksum="4645A462C9BED824" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSF7</accession>
    <name>N1PSF7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_32953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSF7"/>
    <dbReference type="HOGENOM" id="CLU_397950_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="692" mass="74521" checksum="4B4EE6AB2C733348" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSJ8</accession>
    <name>N1PSJ8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_70058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSJ8"/>
    <dbReference type="STRING" id="675120.N1PSJ8"/>
    <dbReference type="eggNOG" id="KOG4561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034597_0_1_1"/>
    <dbReference type="OMA" id="AQWYNGM"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="69"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME45908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="415" mass="46692" checksum="BBD21EDD745A35FA" modified="2013-06-26" version="1">MKDPFPIAPPKALIELVKPIADPLGLPSLALHAHEVLFAFGLYIFIDTVVSPVLSSRLVPDTYNKLNKRTRLNWDVHVVSFFQSVLISALSLYVIFYDEERASLRPRGRWEERIWEYTGVSGLCQSFALGYFMWDFYKCAWHLDIFGWGMLAHAISAFSVFALGYRPFIYFYAPIFLLYELSSPFLNIHWFCDKLELTGSIYQAINGAFLTGTFFACRLVWGNISSFWVFYDIFHAIQSGSTTISNNETGAPKHYSADDLLSIYGDEQGQRLAFAGGYKVPIWLGLVYLTSNLVLNSLNIFWFGKMLATIRKRFDPPLGTKGVGEEYSGYEPKEKVKKEKAYNTSTAQRLDPSAGQITNSSGKGSVRAARERAEAAMDGAIASSEDIDSQRVTLADGSKGIQIEGQRTLRTRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSL7</accession>
    <name>N1PSL7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_42958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSL7"/>
    <dbReference type="STRING" id="675120.N1PSL7"/>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074611_0_0_1"/>
    <dbReference type="OMA" id="HRCPWAH"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF8">
        <property type="entry name" value="S-TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="114"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28453" checksum="EF2A572EA5D4B5F9" modified="2013-06-26" version="1">MATTTGTNNHVIGNDIAAPKITLYTNHRCPYAQRAHITLDELKLPYEEVLIDLDTPRPQWYLDINPRGLVPSIKYSVPGVYNEEIITESAIVAQFLVDSFPSHLLPGTRESAKAPLQRARIGFFVDTWSTKVGSNWFQVIMACAEEKEAKVDDWVATVKKEIEPLLAGANPFFGGSEKLTFAEVIAAPFILRFYALAEDGELIPKSLIEKFDALPNFGKWAKVIREHPTVTKVWDEKDAIAGTKRKVASLKAGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT52</accession>
    <name>N1PT52_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT52"/>
    <dbReference type="HOGENOM" id="CLU_2061423_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="119" mass="13018" checksum="D3989F8056F4299A" modified="2013-06-26" version="1">MGQSTVVDSLRCSPYSCELTAVAHFYACQQIVVHCSHGHAVVLEIFRLRPFSAHRVFGMLSVLSARSDAVPATGPAGMRCKTGKVLYSFRPFYGTDHLPRRCAEDISFSNAMRSSAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU27</accession>
    <name>N1PU27_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_22516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU27"/>
    <dbReference type="STRING" id="675120.N1PU27"/>
    <dbReference type="eggNOG" id="ENOG502QW2A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1272274_0_0_1"/>
    <dbReference type="OMA" id="NDSRDMT"/>
    <dbReference type="OrthoDB" id="9970295at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925">
        <property type="entry name" value="GLYCOSYL HYDROLASE 43 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME46448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="217" mass="24637" checksum="B54E7DB48DA165BA" modified="2013-06-26" version="1">MTDTGGNLVQAHGGHIIQAQDGDSAWYWFGEDQTGETTSGHFIGVSCYKSTNISNSRVVERPKVLYNDQNSEYVMWFYGDSSDYGDAQVGVATSKTIDGQYEWKGNFKPFGNDSRDMTVWKDPDDGKAYLIFATSNNADFQIASLDDDYYNVTEALYTFRDVYQEAPGVFKIDGQFYLLFSPQDGWTPTTMATTLQPAWQALGRRKNYSRRRFLMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUB2</accession>
    <name>N1PUB2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aldose 1-epimerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_70077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUB2"/>
    <dbReference type="STRING" id="675120.N1PUB2"/>
    <dbReference type="eggNOG" id="KOG1604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_0_1_1"/>
    <dbReference type="OMA" id="VWDVEPF"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000014">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109606" description="Aldose 1-epimerase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME45950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="45126" checksum="923C53AE31260643" modified="2013-06-26" version="1">MMLSYGFWSAVAALPLLTVAQDTISRPSVLPNGKYEISAEGIRAQFIPYAASITNLFIQDVHGVERDIVLGFDNATCYSISKLHPHLNGVPGRYANRIKNSTFTIDGTTYHTDPNDNKGLDTLHGGSNGWDYRNWTLVAHAPDSITFSLADGDGEMGFPGDVVANVTYTVTPYQWHLRMTALATTKKTSIMLSSHDYWNLDGYQNPDTPLVLNHTLHMPYADQRIAIDGISVPTGDILINAKNGLNDFWSSPKQLGANFTNPDLLGNCGTNCTGYDNCFLTNRDQLGSCDWRENPVLTLASPFSGIQVDVYTDQQALQVYTCNNMNGTFALKETQGFFNDPSRPRVSNKYGCVVLEVEDWIDGINHPEWGRERRQIFGPADDPYVLQATYNFSLNHELVASNDGTTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUG3</accession>
    <name>N1PUG3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_70137</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUG3"/>
    <dbReference type="STRING" id="675120.N1PUG3"/>
    <dbReference type="eggNOG" id="KOG1341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005947_4_0_1"/>
    <dbReference type="OMA" id="NNHPRDV"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME46044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="731" mass="82314" checksum="878DC7CF23AC0CA6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUI6</accession>
    <name>N1PUI6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUI6"/>
    <dbReference type="eggNOG" id="ENOG502QZRU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1635344_0_0_1"/>
    <dbReference type="OMA" id="WSHASPE"/>
    <dbReference type="OrthoDB" id="3621732at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18194" checksum="FBE81EEF994827C8" modified="2013-06-26" version="1">MEDRPEQPHIDDESADLTTKEKLERQMQGFISAINKRNFDPNSAAWSHASPEFSGEVERPPGDSDLTPPGMMPLREHLAMFQFMAQMYPGFFISIFDLTTEIDEQTGMATMFWNGETHGVPTGVVLPSVGICDFKRYGRKWMCISFKGARGMSDGIPDMPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVS3</accession>
    <name>N1PVS3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVS3"/>
    <dbReference type="STRING" id="675120.N1PVS3"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_765093_0_0_1"/>
    <dbReference type="OrthoDB" id="3791627at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="101"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="362" mass="40363" checksum="92878C9CA279DB19" modified="2013-06-26" version="1">MKVTRELRFRGISLRLAAVLKSPRLSVMALAMQFGEQATAQDAYRPLSLVPSDVTLARVDELLQPWEIQPSAVDDIMPTTDEQARHVALIYSAARTLLLYHTLDGSGPLAIDKLEIAIARLVARFSILRTVFMPHRNSFLQVVLKRSDTHTAVVEASNGDTLDMVCDRSVENDVVEDLLFGTCLTRFIIIHCKDQYRIVCRISHAQHDGMSIANMWTAFEALCSTDRVPRAPDNKHSFAQHMRTLAKLDTPAALSHWQRLLNKSSPTRLKAQSTCQLNFDEGPSITSTIFEQSMRSIDYTFATVLKAAWAAVLAKFCAKQDVVFGTLINGRSEADAQEILGPCSPDDDRQRLSRAGPPCYCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVV6</accession>
    <name>N1PVV6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">40S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_165834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVV6"/>
    <dbReference type="STRING" id="675120.N1PVV6"/>
    <dbReference type="eggNOG" id="KOG3311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_0_1_1"/>
    <dbReference type="OMA" id="SYKGVRH"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME47068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17798" checksum="194F68DD1682C6B1" modified="2013-06-26" version="1">MSLVSGEKSNFQFILRLLNTNVDGKQKVMYALTKISGVGRRYSNLVCKKADVDLNKRAGELTSEELERIVTIIQNPTQYKIPTWFLNRQRDIVTGKDEQVLANGVYSKLRDDLERLKKIRAHRGLRHYWGLRVRGQHSKTTGRRGRTVGVSKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWF4</accession>
    <name>N1PWF4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWF4"/>
    <dbReference type="STRING" id="675120.N1PWF4"/>
    <dbReference type="eggNOG" id="ENOG502S447">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138059_0_0_1"/>
    <dbReference type="OMA" id="WLHVPME"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10178">
        <property type="entry name" value="PAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="161" mass="16451" checksum="CDF30BF75DD43235" modified="2013-06-26" version="1">MAAPTAATLPQVNAFPAPFPAPSKSAAGEIDGVHTDVSSIAFADKIVITISQAGKLAHWVHVPIAAASADPMNPGIMSTDSSENNLLPMSHLTATTVLGGTKREDEVVGQTLATVIASAILMKSPSEERLLVVALGLEDAAGSLTGRAQFDEAVGLVLEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX61</accession>
    <name>N1PX61_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX61"/>
    <dbReference type="HOGENOM" id="CLU_2564600_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="82" mass="8441" checksum="876388D0674651CF" modified="2013-06-26" version="1" fragment="single">NSYATVNSPRASFSSTTPYQNNIAGLLVSASNFSAVINVRIASCIPRHTASILTLCSSISSPWPPTPAATPAPPLPPPSSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX65</accession>
    <name>N1PX65_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX65"/>
    <dbReference type="HOGENOM" id="CLU_987029_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="282" mass="31123" checksum="532AD476BDFBCF70" modified="2013-06-26" version="1">MRHEILLACLHCIAVGRLEERRYLLSSSAKQQRLRSIEKSALCTCLDARRRAGPTYQEREQGAQRSLETTSARRPSGCFAESGERKTFFEIGTRFQLDVRPANMPLRCASSANRTTHGPRGYNLTHRTAVPGVLGRAALVEPAGILYLVVGVCPCAVWVEALDLAEEQTYLEDHSPQSSHRATRYNHCIAKLILPGHCNTEQGDTYDAGGGSGAAAVVLVWVWIKAYLSDNIPMITDGRRMRGKLQLSRLLLQPGSTIVRRSCFYPGVVVEVSKVALCIGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXK8</accession>
    <name>N1PXK8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="11">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_147397</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="11"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXK8"/>
    <dbReference type="STRING" id="675120.N1PXK8"/>
    <dbReference type="eggNOG" id="KOG3146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074922_0_0_1"/>
    <dbReference type="OMA" id="VYATLIW"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000003">
        <property type="entry name" value="Dolichyldiphosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="12">
        <location>
            <begin position="52"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME48147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="234" mass="26317" checksum="9F31957BEF86DFAB" modified="2013-06-26" version="1">MSDPPLASLSLTHVRYNPADPLSHISAYLALVPQALMIAYVSLIWGTREIEIVLMFVGQLGCEALNWILKRYIKEERPTQMLGKGYGMPSSHAQFVAYFSAFLTLFLLFRHDPNNHPHASNTHLPIPLWQRLGLAALSLVSAAAVAQSRIYLNYHTPKQVYIGIGAGVSCAAAWFVVTSAARRFGVVDKILELPLMRWLRFRDLVVHEGLEDAGWGRWELAKQKRAELVAKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXV2</accession>
    <name>N1PXV2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitrilase</fullName>
            <ecNumber evidence="4">3.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_60577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="4"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXV2"/>
    <dbReference type="STRING" id="675120.N1PXV2"/>
    <dbReference type="eggNOG" id="KOG0805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_6_0_1"/>
    <dbReference type="OMA" id="WYPYFSF"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="5">
        <location>
            <begin position="11"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME48252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="328" mass="35777" checksum="28DD4F834499071C" modified="2013-06-26" version="1">MVVSASTSATVRVAVTQHEPVWLNLEGTVNKTITLIKEASQVSARIIAFPECWIPGYPAWIWSRPVDFDLGTRYVQQSLKVNSPEMKRICAAAAENQIAVALGFSERDGDSVYIAQALIDETGELKMTRRKMKPTHMERTIFGDAAGGHCLAKVVDVKDVGRVGGLSCWEHIQPLLKYYTFAQGEQIHVAAWPPLEPFIEGSPGFYSMSVEGCRNQSQAYAIESQSFVLHSTTVLTAGGIEAMSTKGAPIMGHANTGSSAVFGPDGRILTPMENPPEELIIADVDLSLVTKTKTFADASGHYSRPDLMWLGVDEKQKLVVRPQNVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYL3</accession>
    <name>N1PYL3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_29951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYL3"/>
    <dbReference type="HOGENOM" id="CLU_1660706_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="159" mass="16165" checksum="2E369439E92146A6" modified="2013-06-26" version="1">MPYSRCPSQQELSVLFEGPVGRKGGLTLVAIGGGGQVDPGTVLQADTVACTAAAGGAAQGWPGGSSADDVEEEAEPRGERKDEAEANTTRLSARAETANSRSSSEESQTPSQISAPFAQSEPGQAPTDQRNNSQDSEAPALLQLGRPAITTINASSPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYP2</accession>
    <name>N1PYP2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rgp1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_67597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYP2"/>
    <dbReference type="STRING" id="675120.N1PYP2"/>
    <dbReference type="eggNOG" id="KOG4469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005862_0_0_1"/>
    <dbReference type="OMA" id="VLGHDLM"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="872" mass="92955" checksum="F41892E5888FCE4D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYW2</accession>
    <name>N1PYW2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_167816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYW2"/>
    <dbReference type="STRING" id="675120.N1PYW2"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_1"/>
    <dbReference type="OMA" id="CAGGWYT"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="3">
        <location>
            <begin position="23"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="186"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME48168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="39634" checksum="4D3E8FB623795B68" modified="2013-06-26" version="1">MKAARFHARGDIRVDDVEEPVPGEGQVIVDIEWCGICGSDLHEYLIGPITVPTKENPHPISQATIPVTLGHEMCGKVRSPPAGSKFKHGDNVMVDPRVFCTSCLACKAGRSHCCSRLGYIGGSTGFGGFGETVVVDEGNLYLLPPEIGMECAAVLEPLVIVHHAMKVSGIAEWKDKDILVLGGGPTGFALLLCLKAAGARNVIVSEPTALRRQQVSQFCHTVINPIEEDVPERCHELTEGRNVQIVFDCAGAPRALSGALDALRFEGLYIMVAVWEQDITIPCWKFLAKHITMKGTLIFDDDAMLEVMQMIVDGKLTGYENMVTGRIALNDIVEEGFQELVNNKDEHIKILVSPRSRRDSSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZ15</accession>
    <name>N1PZ15_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA amidotransferase complex subunit Gta3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_67722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZ15"/>
    <dbReference type="eggNOG" id="ENOG502SERM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085810_1_0_1"/>
    <dbReference type="OMA" id="RIGHYQR"/>
    <dbReference type="OrthoDB" id="5522061at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049545">
        <property type="entry name" value="Gta3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20978">
        <property type="entry name" value="Gta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl-tRNA amidotransferase complex subunit Gta3" evidence="1">
        <location>
            <begin position="64"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="195" mass="21573" checksum="0154AAF7D3321785" modified="2013-06-26" version="1">MSFRSLYKAGSSRVKVITYRGQHRALSNCTALCSQAGSNKIDVEELLATPSWSVASLLPSDQESPGALGVTSEQLHHLLRLAALAPPKDQEEEKRMLSTLSSQLHFVRDIQQVDTTAIEPLLSPRDETARGEKDAELGMEALKEALAGEEVRGKHHKRIRRRQDLVVEDREGKWDVVGSASKKVGRYFVVEGGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZC6</accession>
    <name>N1PZC6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZC6"/>
    <dbReference type="HOGENOM" id="CLU_1378089_0_0_1"/>
    <dbReference type="OMA" id="MAKVAMW"/>
    <dbReference type="OrthoDB" id="10392570at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="198" mass="22274" checksum="E8E8D1A85E33B987" modified="2013-06-26" version="1">MLSLKHKSPKAGSPVQQGAYPAKQDKSVDQGTQQPARREERSVESQEVVVIVRHFGDKKARLKGKDPVQVKEGTGEVDGEMSLTELYRELRQLALLSVGMKATTPGFHGSLLIQAPGHERVALVNEQDWKQHRGLLKVRATRLMLDFDIDSLEVKETTKSSSWLDKARGKAMAKVAMWDDAIKREKSAQQEQFNNPWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0E5</accession>
    <name>N1Q0E5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_84588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0E5"/>
    <dbReference type="STRING" id="675120.N1Q0E5"/>
    <dbReference type="eggNOG" id="KOG2565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_0_2_1"/>
    <dbReference type="OMA" id="YSAMMVT"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="401" mass="45682" checksum="76F8482FDCDEE35E" modified="2013-06-26" version="1">MSTYDIYVPEEKLVTLKIKLGQSEFPDELDGAAWDYGAPLSDVKRLAKRWQSGYDWRAEEAKLNELPNFHRPIKVDGFGDLDVHYLHSQSDSSDAIPLLFVHGWPGSYLEVTKMLPVLRQSNQGVSFHVVAPSLPNFGWSEGVKKTGFGLVQYAQVCDQLMQSLGYKQYVTQGGDWGFMITRTIGLLYPQRCLASHINMVRGAQPTWSKHPILALEHALTPYGEAEKKGFERTRWFLQEGSGYRVLQNTKPQTLGYALHDSPVALLAWIYEKLHDWTDEYPWTDDEILTWVSIYYFSTAGPAASVRIYYEAIHPRKGGINRDRTEKWIPNVKLGLCFSPKELTVIPSTWGRTLGPVAYESRKLRGGHFAAWEHPNQIIEDLLAMFGKKGKCYQIVRPQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0H7</accession>
    <name>N1Q0H7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_67723</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0H7"/>
    <dbReference type="STRING" id="675120.N1Q0H7"/>
    <dbReference type="eggNOG" id="ENOG502S7S9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138649_2_0_1"/>
    <dbReference type="OMA" id="KPEAEGW"/>
    <dbReference type="OrthoDB" id="2147978at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME48773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="124" mass="14074" checksum="75132008553018AD" modified="2013-06-26" version="1">MTMSLLRATRLISTSRTRLQVIPNIAARPQHRQVSASATRSAGDQAHEDHYDPPGGWLWGIKPGEKPEAEGWENVWFYGFFGSLLFGVVGYCYKPDTSIQTWALEEARRRLEAEGILEDPDKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0X4</accession>
    <name>N1Q0X4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_117147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0X4"/>
    <dbReference type="STRING" id="675120.N1Q0X4"/>
    <dbReference type="eggNOG" id="KOG1911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045874_0_1_1"/>
    <dbReference type="OMA" id="VERICNH"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="154" mass="17553" checksum="85F2AB3342894B20" modified="2013-06-26" version="1" fragment="single">KGQTFYQVKWMGYENDEDLTWEPKENLETAPDILEAYHQKVGGTPEPPNKKGAPAGKRKSEAQDSPAPKKGRKSQINGFAEWEPPLGSWEEHVTRVAAIIEDDLEAGVIKKAKTEPKDLSGLLEWDNGRKTQHNMQLLRQKCPQRLLDYYESHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q202</accession>
    <name>N1Q202_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_68476</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q202"/>
    <dbReference type="STRING" id="675120.N1Q202"/>
    <dbReference type="eggNOG" id="KOG4139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017715_0_0_1"/>
    <dbReference type="OMA" id="GMKIWAI"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="609"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="663" mass="74249" checksum="6E37DD2CFA6E64E0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q207</accession>
    <name>N1Q207_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stc1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_49987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q207"/>
    <dbReference type="STRING" id="675120.N1Q207"/>
    <dbReference type="eggNOG" id="ENOG502SB6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1035013_0_0_1"/>
    <dbReference type="OMA" id="LVEIECF"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024630">
        <property type="entry name" value="Stc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12898">
        <property type="entry name" value="Stc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stc1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="289" mass="30199" checksum="8BF4CDC1420479C8" modified="2013-06-26" version="1">MAPAATHSGYNNYNHFPRQNGVAVPSSIKCTRCDIVKSKGAFSNGPQADLVAHMKRIGPGFNAAKTAYIACMACTPKQVVELHCYMCDMDKGLDKFFKTQRRTPDHALCMACQQDKLNYEPGAMSDDDSSGGGTDDSEDSDDDRLSLVDGITSMSVSGAGTMPPARSSTVGGGVSLDGSKAPSSTVTASTTGAPTTASTTDNVTSRAASSRASAAAVAARYGTPSSRTASSVAGTTTSTRPSGSWAKPKTIQRKIQYDDVAQQKREEQMAKGNVNDDEKEYCGAGSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2L0</accession>
    <name>N1Q2L0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_49733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2L0"/>
    <dbReference type="eggNOG" id="ENOG502S92K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064039_0_0_1"/>
    <dbReference type="OMA" id="GWHIVVY"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052358">
        <property type="entry name" value="Aro_Compnd_Degr_Hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563:SF2">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="26"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="299" mass="33029" checksum="10BA559F1121B7DA" modified="2013-06-26" version="1">MASKRTHSTSNFSRLAARIPDGTWCAHMHVVDPITFPLDKSAQYTPSPHNLDQAKSFLGSLGITKMVIVQPSIYSNDNACTLDGLRQLGIDNGRAVVQFDPSATSHAQLQEWHSLGVRGVRLNLKSVGATPSAKALKQTMQVYGDAVRPFGWPLELYIALEDVPLLEAIGDGLVHTKVIVDHFAHPTAASLRGANSAYDIEGFQSLVRLLRKGNVWVKLSASYRLSKDPNDPVVESLCKEILRVRPDRCVFATDWPHTRFENVEIGAYLDKILDWIEEEGVSLSQVLVTNAEELFDARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2W5</accession>
    <name>N1Q2W5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2W5"/>
    <dbReference type="STRING" id="675120.N1Q2W5"/>
    <dbReference type="eggNOG" id="ENOG502S0Z5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035325_0_0_1"/>
    <dbReference type="OMA" id="PGMGFYQ"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="547" mass="58169" checksum="B4AD8F9CBB114073" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3C8</accession>
    <name>N1Q3C8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_142514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3C8"/>
    <dbReference type="eggNOG" id="KOG2819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032056_3_0_1"/>
    <dbReference type="OMA" id="YRKNDQK"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="486" mass="53018" checksum="5E678D37701452A3" modified="2013-06-26" version="1">MAAEPLAVVPGHSLGFVYLGAALQQVLSSLKGDKDRFPAIHLSYTQSRPLSAPVVVTLPENGLRLRFDGSDQRLRLIEVLDFARTRLTYKASELVKKQEDGASATFKRIYQLFGASYPGEYLPPKSGRDGTYVLSWPGVAFNFPLQHAAWSPDKDHVSLLGSHAAAPATHMAIFDGHSWPEARNTLFVQIPSAPRTPALTAQPRDALPPEIELAIIETDGKISLERRAPALPFHIVLNQTTPQDLITELGAPEATHRRDVPVATEEPVNAHPRNNSRSLAHGRPHATPPSSYSSTGTDTFDTDFDSGDADDDSERLGRETFWCYFSHGMDILVGPPSDQVSVVEINNADPTPLFTSPHLVVVKVVLHGNVPGSYAFNRHRRSRWVVDLPGARSIVSSETPFEETKAALMQAFQGIIPESEMGRGKVVNRTWGPNPTDSTFFLPDADQDLVEGGGSESGLDNTKLYDLGFLQFEVASNDAVVAMTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3T6</accession>
    <name>N1Q3T6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxisomal biogenesis factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_69028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3T6"/>
    <dbReference type="STRING" id="675120.N1Q3T6"/>
    <dbReference type="eggNOG" id="KOG4186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049216_0_0_1"/>
    <dbReference type="OMA" id="AYHPTVA"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME50357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25935" checksum="3042D20ED610CEDD" modified="2013-06-26" version="1">MVADALIYHPEVAHFNRFVATTVGRDKLLRTIQYFSRFLAWYLYRTNHPASTVAVPETIKKQFSSVRKAIRIGKFVEHLKAAAIASDSKSLDPVLKYLAVGRQLGYAVYLGLDTLCYIDQSGIYKLKQGARLQREAYRAWFAGLVCNIAAGGYTLWNMREVAKRQEASGDAEKVVEQKRLEKERGAAQLQLLSDVCDITIPANAIYGRFDDGIVGIAGTVSSLIGLQAAWAKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q419</accession>
    <name>N1Q419_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_19902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q419"/>
    <dbReference type="STRING" id="675120.N1Q419"/>
    <dbReference type="eggNOG" id="ENOG502RXIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084253_1_1_1"/>
    <dbReference type="OMA" id="AIFTCMD"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03379">
        <property type="entry name" value="beta_CA_cladeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="166" mass="17946" checksum="0C122F35659F2F7C" modified="2013-06-26" version="1">MATDTQQNLKTKNEQYASSFDKGHLALPPAKKYLVVTCMDARIDPAAAYGIDLGDAHVIRNAGGNAKDALRSILISQHLLGTREIILVKHTGCGMLTFTNTDALSVVANNVGTGVLASTFDFQPFGDLEKAVKDDVDWLKEHSALVGKTITGWVYEVETGKTRQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4N5</accession>
    <name>N1Q4N5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_144136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4N5"/>
    <dbReference type="STRING" id="675120.N1Q4N5"/>
    <dbReference type="eggNOG" id="ENOG502S090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039475_0_1_1"/>
    <dbReference type="OMA" id="LWVHQLQ"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000051">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF263">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="105"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29399" checksum="5B04EB5A3E7F1497" modified="2013-06-26" version="1">MAEHPSYELLYHPAIPGRGEFVRLAFEAAGVPVTDIANSEKDGYSEVQKICANKDIESSDGNPPIFSPPALRVPGKGRDGKALVISQTPNILLYLGDKLGLVPDDEAGKLYVNQLTLTALDLANEIHDSHHPIGVMLYYEDQKTEALRKAKDVRENRFPKFFSYFSRVLEHNERNGGGGKYMVGDKLTYADTTVWQVLDGVSFAFPKELEARRKEFPLLFDTFYENLKQEKGLKEYIKSARRLPFSQGLFRYYDELDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5B6</accession>
    <name>N1Q5B6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_31417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5B6"/>
    <dbReference type="STRING" id="675120.N1Q5B6"/>
    <dbReference type="eggNOG" id="ENOG502S6HP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_482334_0_0_1"/>
    <dbReference type="OrthoDB" id="3650858at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="565" mass="64624" checksum="3E86FBA4BA0DF7E9" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2WHU1</accession>
    <name>M2WHU1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_57684</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WHU1"/>
    <dbReference type="STRING" id="675120.M2WHU1"/>
    <dbReference type="eggNOG" id="KOG0686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022348_1_1_1"/>
    <dbReference type="OMA" id="IYLQNWA"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="248"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME38172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="479" mass="52903" checksum="3EFBD53317BEC67C" modified="2013-05-01" version="1">MARRVSTANLPPPTFDLETYASNYEGPLLPLRLAHIATHCPTLSRQALTLAFDHAKNGKDVQLYHRLLDLAINLGFEDLGREDTEWAAKKDEENRRELSRLESELRGYKNNLIRESIRMGQEDLATHHLLTGGPIPDPNNPQSVNSSGYNAAYSQFGKMRDFCTTPIHIAAMTLRLIYTSLLQAVTTSQFGGSGSMHFNNVLINASRLRNSGVKEEEQTKLTPISYVMSGLACMAQGEYATAAKTLLQASFDYHNMGPVFGSDLERTVASANDVAVYGGLCALATMSRDELNDEVLGGPFRAFLEQEPHMRKAITLYTTAKYQSCIETLRRYYSDWTLDVFLGATSASVYGSHVDRLIAKIRERSITAYFSSFSEVSLASLASTFPPNPDTPAAMEAEVLLMIDSGILDARLDVVNGVLIAPRKEARQAAHNDAKQTAEEVERTLLLRLHKVNMTLAGLEVPKAKNQWNSGSLGNGHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2WM95</accession>
    <name>M2WM95_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_72519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WM95"/>
    <dbReference type="STRING" id="675120.M2WM95"/>
    <dbReference type="eggNOG" id="KOG0858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051898_7_0_1"/>
    <dbReference type="OMA" id="LWRCVTS"/>
    <dbReference type="OrthoDB" id="19102at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="188"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME43163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="232" mass="25435" checksum="FC997DEDB9562A74" modified="2013-05-01" version="1">MWVVFLSDYIFTIRQLPQIWRLVTSFFVTGPQLGLIMDPFFLYHYSSQLETGSPRFSTPGAYAFYILFVSTVILLTGGFYLGGITLLNPLSMALIYTFAQDDPNRVVQFFIVQMPAKYLPYASLAITYLMAGQYATLVQATGILAAHLYDFLDRIWPRFGSGPKLIQVPQWIQRQFAAPAGVGQGRSYGTAFTGRTGGPGQPPAQNQTGSGGGWASGSSWTGRGSGRRLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2WNM8</accession>
    <name>M2WNM8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_72853</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Golgi apparatus</location>
            <location evidence="9">trans-Golgi network membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WNM8"/>
    <dbReference type="STRING" id="675120.M2WNM8"/>
    <dbReference type="eggNOG" id="KOG3202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061883_0_0_1"/>
    <dbReference type="OMA" id="EHDPYRF"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21444">
        <property type="entry name" value="SNARE_NTD_Tlg1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000004">
        <property type="entry name" value="Syntaxin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048036">
        <property type="entry name" value="Tlg1p-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="140"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME43618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="232" mass="26169" checksum="BB657625BA8C0503" modified="2013-05-01" version="1">MSDDPFLAAQADVLSLLDQTRSQLKSYLRIRSTSSASPELVEARQELESTLTDLSADLQDLVDSVKAVEGDPYRYGLDVAEVGRRRKLVQDVAKEVEDMHQQLNATAAQADAQLAHPDNFAVDEEDMGDEYGEWEEQRQMEIMHEQDEALDGVFQTVGNLRMQADTMGRELEEQAELLEDTENITDRVTGKLETGMKKIRYVIEKNEDRYSSCCIAALIFVLILLLILVIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2XG56</accession>
    <name>M2XG56_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_141234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XG56"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="NAIVIMF"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="66"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME38051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="516" mass="57039" checksum="D852D9562E05FC65" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>M2XGB7</accession>
    <name>M2XGB7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_75972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XGB7"/>
    <dbReference type="HOGENOM" id="CLU_2885743_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="63" mass="6709" checksum="55476845ACDDAB12" modified="2013-05-01" version="1">MLSVPPSIQVGGVGMIHLRQTSQGSSTRSSYAGRWWCVPTVRCPEIGQEDSPSKSPKTAAYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2XJ67</accession>
    <name>M2XJ67_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_75238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XJ67"/>
    <dbReference type="STRING" id="675120.M2XJ67"/>
    <dbReference type="eggNOG" id="KOG0184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_0_1_1"/>
    <dbReference type="OMA" id="RVSMYMH"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000044">
        <property type="entry name" value="Probable proteasome subunit alpha type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="4">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="291" mass="31427" checksum="9DD6AE3AFCBFC73E" modified="2013-05-01" version="1">MTSIGTGYDLSNSVFSPDGRNFQVEYAVKAVENGGTAIGIRCKDGVVLALEKLVTSKLLKKDANKRIATVDRNMGVVHSGLLPDGRHFVSRARDEASSWRSTYKAPIPVSSLANRMGAYVQAYTLYSSVRPFGITAIIGGWDAETEVDVDGAVGSGPKSGSGGKTKGVKEGGPYLYMIEPSGLYWGYYGAATGKGRQAAKAELEKLKLDPKEGDCISLEEGVKEAARIIYVAHEDSKDKDFELELTWISAVNGPTKGRHEEVPKTLREEAERLAKAALEGDDDEEEGKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2XJF1</accession>
    <name>M2XJF1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_75294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XJF1"/>
    <dbReference type="HOGENOM" id="CLU_2739991_0_0_1"/>
    <dbReference type="OrthoDB" id="3650820at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="71" mass="8764" checksum="1CD02589E9468587" modified="2013-05-01" version="1">MQECRRKYEEEMRKLHRPMLDRLRELLAKKRDIESQLEQYHDLKDQTFEAAVQHYQTAATDRTRQIEVEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKE9</accession>
    <name>M2XKE9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_88968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKE9"/>
    <dbReference type="eggNOG" id="ENOG502S09K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071379_2_0_1"/>
    <dbReference type="OMA" id="VGAFHYG"/>
    <dbReference type="OrthoDB" id="5580261at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="201" mass="22274" checksum="15832A2A3206EC6C" modified="2013-05-01" version="1">MSSHGGPTAYQTIRSSSTETLRSTSRIARIESRLPRFLRRYITPLRTAPLSHISAFLILHELTAIIPLFGLAGAFHYYNWLPPYISEGKWVSDGTEKFGKWMRKKGWISDEERSGRYFGKGESGTRIVVELATAYAITKVLLPLRLIGSIWATPWFARWTVLPITRRFGGMMFGTKKAVAVKDVKAAGTGAVGGGAIPKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKG7</accession>
    <name>M2XKG7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_132174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKG7"/>
    <dbReference type="STRING" id="675120.M2XKG7"/>
    <dbReference type="eggNOG" id="ENOG502S0TT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047034_1_0_1"/>
    <dbReference type="OMA" id="SVLWWKS"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="88"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="307" mass="34594" checksum="DC27D56CCB8892BA" modified="2013-05-01" version="1">MCPRKPVLQSSDDLLICNECGTQYAVREDSGQDECKVCNDPRQYVPATGQVFTTLGKLKDAGHKNVWWQDEHNSKVWSVKTYPSFAIGERAELIQTDKGNILWDLIPLIDQETVDKIVELGGLEAIVISHPHYYSTWADWSRTFNCPVYVGAPDKIWLERVDVPGLHDIYTPILEGSGVTAILAGGHFPGSLLLHWNDILFIADTIFTSPSATNPVPGKEGVISFTLWYSIPNRIPLHPDEILRIWQIVKPYDFHFAFGAFRGQDVRTMPNEQERGTGGPKGRLLESCKIYVRAMGWREHGLFGETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKY9</accession>
    <name>M2XKY9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_72525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKY9"/>
    <dbReference type="STRING" id="675120.M2XKY9"/>
    <dbReference type="eggNOG" id="KOG3382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110455_2_1_1"/>
    <dbReference type="OMA" id="WHGWIHH"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="130" mass="15303" checksum="4B1CF7A5658E141F" modified="2013-05-01" version="1">MSTILRTLRNLRSIGLKEYGHQLHRGALVGIDRYGNKYFENLEEELPLRTRWVDYKDNEYDPSQIEPGWHAWMSYMVDKAPSEDKLLQRGIRPWEPKEHVPVMTASRSAYKPFNTTKNKYAPWTPVAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2XML2</accession>
    <name>M2XML2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_45533</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XML2"/>
    <dbReference type="STRING" id="675120.M2XML2"/>
    <dbReference type="eggNOG" id="KOG2007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_3_1_1"/>
    <dbReference type="OMA" id="EAYWSTP"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.640">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="12">
        <location>
            <begin position="44"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="761"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="778"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME43692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="796" mass="89488" checksum="04A7D069AE695470" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y1I3</accession>
    <name>M2Y1I3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_47786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y1I3"/>
    <dbReference type="HOGENOM" id="CLU_2158287_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="111" mass="12145" checksum="791A6BC98479034C" modified="2013-05-01" version="1">MKAWSDIRSLCSGVSSGSFTFRGVCNTRHSPRACEHGLSEFGQSGNNEEHIENAVSRPWVIEMRIARSLPSRGSGEMQRYVACGKAPGDEVESDVRLGNGFEVISTDRVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y208</accession>
    <name>M2Y208_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_179814</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y208"/>
    <dbReference type="STRING" id="675120.M2Y208"/>
    <dbReference type="eggNOG" id="KOG2231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008515_1_0_1"/>
    <dbReference type="OMA" id="VFTHEHT"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="114"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="360"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="621"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="762"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME39324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="783" mass="84828" checksum="F07670B0E7963BB1" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y484</accession>
    <name>M2Y484_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_72471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y484"/>
    <dbReference type="STRING" id="675120.M2Y484"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="OMA" id="ATGWDWE"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF123">
        <property type="entry name" value="GMC OXIDOREDUCTASE (AFU_ORTHOLOGUE AFUA_2G01770)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME43104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="549" mass="59496" checksum="A37712CFC57BF2FC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIP1</accession>
    <name>M2YIP1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_75492</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIP1"/>
    <dbReference type="eggNOG" id="ENOG502QPXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014819_1_0_1"/>
    <dbReference type="OMA" id="VWFTEHV"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005140247" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME38776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="537" mass="59055" checksum="2F492B70FBEC9D05" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIW4</accession>
    <name>M2YIW4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_75553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIW4"/>
    <dbReference type="STRING" id="675120.M2YIW4"/>
    <dbReference type="eggNOG" id="ENOG502SMB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014183_0_0_1"/>
    <dbReference type="OMA" id="QGHEGDW"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF19">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="100"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME38875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="458" mass="50658" checksum="74B9F9011CF18879" modified="2013-05-01" version="1">MNLPSHLAPDRLKIMIVGDSMTHGEEGDWTWRYRIWEWLQHSVPGIKVQFVGPYTGTVPPPKSHPPVPPRLPGDSDPDERDSMAGGYAKDVSSSFDKEHFSHTGRQMKQAKDEIHSQVSIYKPDMLLTMLGFNDLGWLVSSGADETLEDTKSFVDQARAANPEIHLVLGNIPQRSHIDRDDLVKKTSKYNALLHHAIPEWSTARSRIEGVEIERSYGYVPDECKGTFDGLHPNALGDYQIACAFSRTLHHAFGFGSKPLTMPKHIPKRPLPVPSNLKACGAPYGVVCTFDAVYGSHGYDTRQRRQGESDWDEGFTGMNRIDHTFTSPGEKWEFQVRASGGLHEKGEWSEIVRATAERSTAPSPKNVQVYSTPLGFEATWEPLDDSWNVDRYVALYQDKTDNGFLCGVASRGTSASVSDLATGHRVDVMMQTWTAAGPGVPEHAGTIVVGSGVFSRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJ70</accession>
    <name>M2YJ70_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_57272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJ70"/>
    <dbReference type="STRING" id="675120.M2YJ70"/>
    <dbReference type="eggNOG" id="ENOG502SK3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_347128_0_0_1"/>
    <dbReference type="OMA" id="CHLPTPN"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="870" mass="98305" checksum="53B2F71884C0E560" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJQ6</accession>
    <name>M2YJQ6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_28347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJQ6"/>
    <dbReference type="HOGENOM" id="CLU_2015207_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="123" mass="13746" checksum="99E36642C098FDE3" modified="2013-05-01" version="1">MPTLFESLPVMDEDMDEQRDEHNAPSAESAPAIMRLGSFLLIDTNVRRMIWATISLGTSRYLLTGHVNYPLHLLAVHLAAIQTARIFPATYLRAFTHMPARQFVPDILTVILTALTMLVLISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJY3</accession>
    <name>M2YJY3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_95524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJY3"/>
    <dbReference type="STRING" id="675120.M2YJY3"/>
    <dbReference type="eggNOG" id="KOG0001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_0_0_1"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="126" mass="14092" checksum="2FAF58FD994AE1D6" modified="2013-05-01" version="1" fragment="single">LQMIVKSLTGKRTLIQVKNRTTASYVAQKVEAQEGLPPSHQHLFFDTTVREGGRCHSIQHRPRASTISQQIFTGAIHHRRQNACGKLTRVLISRDTTVSELVRKIGAADGIPPCQQRIIFAGRQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLM3</accession>
    <name>M2YLM3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 6B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_173406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLM3"/>
    <dbReference type="STRING" id="675120.M2YLM3"/>
    <dbReference type="eggNOG" id="KOG3316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076409_0_1_1"/>
    <dbReference type="OMA" id="CKEFWTA"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24627" checksum="B21493D1D3065F9E" modified="2013-05-01" version="1">MSRAPAAQVDIEDLNNPKLNVSCLDFLLIELVPLAQRITDQLHAREQALVDEFKSTNSVKDSSFVGGMGSTALGTATVMDDETREAVFWRLDGLGYRVGQGLVERFSAGKPRPTTPLEAIKFICKDLWQLLFRKQIDNLKTNHRGVFVLTDSRFQPLSRMSVDRRAGPKAAEDALRRAQTFLYFPCGVIRGALQGLGIDVTITAETTEIPTATFQIKTKGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLY1</accession>
    <name>M2YLY1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_80559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLY1"/>
    <dbReference type="HOGENOM" id="CLU_1015722_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="274" mass="30776" checksum="EB6C4B498BA4595F" modified="2013-05-01" version="1">MTVKDRIAATDATAIAFPIKSTRSTSTATQENAYSKQKHALQVARLSDSYWLTEEVLPTVGTSRSNSRSQSRSRKISSLKTNCSSSKASLDSSSTTMRSRDIPTDSIAFAEDHKAAKEKRERTKSRSRMIGESPSPRSRNLSTYDMYRLSPEERPCTDCVSSQCQDPKEAVALDPASNPVQIWRHIHVDLHLKPSLFVVRTPATVAKLLKLMFILCGKGSQVALLTRSQNLYCLTFRRHWYGVAKSQLFRRPMSTLVFIDDLEPLAPLRDFSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2YNP5</accession>
    <name>M2YNP5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_25568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YNP5"/>
    <dbReference type="HOGENOM" id="CLU_1722329_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="152" mass="16963" checksum="27429ED8AC72D885" modified="2013-05-01" version="1">MTPLFQIQDSTGKGQALFATQDILAETIIFQEAPVLTVPKSLPTEADMYQVFLQRSYVPHSRFFQVNPLPYPPAKRNKTNSTPSTKAPAPNKSRLDRIYFEKTFEREGACWICLTGSEINDSSACAPNATLIGNSALDEETLHASQDIQNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBI0</accession>
    <name>N1PBI0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_29401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBI0"/>
    <dbReference type="STRING" id="675120.N1PBI0"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1366227_0_0_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF41">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME38342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21509" checksum="B7D48EB012D2E1F6" modified="2013-06-26" version="1">MAITSAYCIGPLDAAAMPAYSFAFIGIFYNATQLHAGATVMTCVITILTLCSVISNVATASRQMFAFARNGGLTFARIWCYVRPGWDIPLNAVVLSFTVTCLLSLTNLGSSVTFNAILSIGVVALLASYVTSIGCILRKSYRNITPRTRVIIGAGIMAYAAAGLFLSDKAEQSFGFTPTEEDKKKLRDAVPTVHMVEREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBK6</accession>
    <name>N1PBK6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_39271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBK6"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1012027_0_0_1"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109692" evidence="7">
        <location>
            <begin position="27"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME38216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="275" mass="30703" checksum="8B43942E7ACB1289" modified="2013-06-26" version="1">MLHCPPWILIPIWPPLFLLQLDYALHATIMKWDEVPPSRSSTLATCTGVYDQALRFGSCDWINTCMAGDARLQSRAWSYIVPYGQAGRHDEYPIASALPYLYGILVAACAKKLTREAYWNIWDVMTFMLPQYPEDHGARFGNFLIAVAMAFSYLADLTAMFPRWMTIRRGQILCTILGIAIVPWKLLNSAEAFLTFSSGYGCWLALIALQHGLARKSDVAVVGQMCFEQRANENDVQNKSEVILDVVEDGSQVSNDVDTTEDEAAAADCNTDQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBL2</accession>
    <name>N1PBL2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Carbamoyl phosphate synthase arginine-specific large chain, mitochondrial</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DOTSEDRAFT_75853</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBL2"/>
    <dbReference type="STRING" id="675120.N1PBL2"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_3_1"/>
    <dbReference type="OMA" id="FPFNKFP"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="221"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="758"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="23">
        <location>
            <begin position="1023"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EME38462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1173" mass="129295" checksum="3A1D2807D49A4025" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBT2</accession>
    <name>N1PBT2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_94778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBT2"/>
    <dbReference type="STRING" id="675120.N1PBT2"/>
    <dbReference type="eggNOG" id="ENOG502S60G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1880337_0_0_1"/>
    <dbReference type="OMA" id="TEASICH"/>
    <dbReference type="OrthoDB" id="5388486at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15711" checksum="F1A1F49024153BFD" modified="2013-06-26" version="1" fragment="single">RSFPCPLTIYGCTSTFGSKNEWKRHVNTQHMRLGFWRCDLCPNGERKPNDFNRKDLFIQHVRRMHPAAASRTEATSSLPKAGKDNESMQALQDAANRCYKALRHPPQQSCCLFCDQQFTGNGSWDDRMEHVGRHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBW5</accession>
    <name>N1PBW5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_74666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBW5"/>
    <dbReference type="STRING" id="675120.N1PBW5"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="OMA" id="YDYKDAQ"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="7"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="365" mass="39498" checksum="5BF6CE1F2CF94229" modified="2013-06-26" version="1">MTSQLPSTMKAVTVNENKAKVSEISVPKIRPTYLLAKIDSVALNPTDWKHINGKRAATNGLAGCDFSGTVVEVGPDVVKTFKPGDRVAGTTHGANYSQPEDGCFAEYAVAKADLLVKIPDSLPFEAAATFPLGVSTVGQGLFQKGLKLNLPDNPFNSDETVLIYGGSSATGSLAIQYATLAGYKVITTCSPRNNDFVKSLGATAAYDYKDPDCGKNINKDTNNALRLIWDTISLQDSAKICEEALSTDAKDPKYWTILPVKLPNRNDVESGFTFMYTIFNDPFHKAGRDTPASPEDFEFAKKFFGMTEKLLEQGKLKTHPGKIGAKGLEGVLQGLKDLKEDKVSGNKLVYRVKETPADSKAEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBZ6</accession>
    <name>N1PBZ6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_37935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBZ6"/>
    <dbReference type="HOGENOM" id="CLU_1098481_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="253" mass="28382" checksum="05AF5F871863A279" modified="2013-06-26" version="1">MVNDSIDRATSRLSKISCSDQKPTMQDLEVRLKDTNITPVSSRGAEKARAYPPQRAPPGTRQMYKVIKVALKKKLSCTRTMPAHQSHLLRSSPKSSLRIEPMARLLAMSSEELPPPPYSSISQRDVTARAFVTDDERGMLQPRDAVLTNLSALPRGSCGMHPGYFCEYHHDTHIQEQRQGTSGYQHPQVQQVVDEDVRAGTFRSEDEVDAWIPYYVLAPDDTQVVPTEKWLLPAQRFKSRSGRYLAVACSVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC78</accession>
    <name>N1PC78_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_75812</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="9"/>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC78"/>
    <dbReference type="STRING" id="675120.N1PC78"/>
    <dbReference type="eggNOG" id="KOG0354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002513_0_1_1"/>
    <dbReference type="OMA" id="EMEMCMD"/>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="318"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="509"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="708"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME38393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="913" mass="100466" checksum="FE36209CD4C4428C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCH5</accession>
    <name>N1PCH5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_28095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCH5"/>
    <dbReference type="eggNOG" id="ENOG502SQ6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_871610_0_0_1"/>
    <dbReference type="OMA" id="VATHRDW"/>
    <dbReference type="OrthoDB" id="4232400at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="319" mass="35904" checksum="E864E0E99B53E706" modified="2013-06-26" version="1">MAPSGEAYEVDWILSNSSNAHVATHRDWFTTFTAFETSIYRSFSTDRCLVLGIGDVHLNVRVAPSSQGVASHKIIILHDVLYCPELANNILGGHIHDDFPLGEATTRLVDSNGKVGCVFDRIEVHLHGFRNDHKTKLWLEGHRQGHFSEGPGLTWKQAIWPGDEMQKWEDYKAVRHWSVSVHDLVEPAAAAEVGKPKSLMRAFFGERRKKSRTPRQQLQHRVNSGAFSLIRNGVAKPPPYTPQEKAWLRDHYGEDFKFKGSAIDDGGDHKDGQSTVSLTRQGPVKKGPKRFGLSRMTKGMQRVTSLIWNCAARSDAWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD18</accession>
    <name>N1PD18_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_112542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD18"/>
    <dbReference type="STRING" id="675120.N1PD18"/>
    <dbReference type="eggNOG" id="ENOG502S7HF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142408_0_0_1"/>
    <dbReference type="OMA" id="CAKAWVK"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase assembly factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME40202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="110" mass="12757" checksum="8C153B5B3290CEED" modified="2013-06-26" version="1" fragment="single">MAWFSSSESQPAPAAAEPSKDGGYIAPDRTQRAQCWEGRDNFFKCLDKNNIIDSVREDEKARQVCLPELREFEKVCQGSWVTYFKKRRVMEHQRDQTIKKLNAEGAQQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD61</accession>
    <name>N1PD61_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lea domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD61"/>
    <dbReference type="STRING" id="675120.N1PD61"/>
    <dbReference type="eggNOG" id="ENOG502SBN9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128874_1_1_1"/>
    <dbReference type="OMA" id="REAAGMH"/>
    <dbReference type="OrthoDB" id="4023585at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="9921" checksum="A0D2500FB1B3F4A1" modified="2013-06-26" version="1">MFRQVVARNVRLFSTSRVVLEKGPIEGTKEAVKQVDRTVSDTLVKGIEKGEEAAAAAKKAAGITGEEAKQKASEAAQSAHDAKEQAKGAAKTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDE3</accession>
    <name>N1PDE3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2 type master regulator of conidiophore development brlA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_75856</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDE3"/>
    <dbReference type="STRING" id="675120.N1PDE3"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_704035_0_0_1"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME38469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="392" mass="43841" checksum="DC40114E44F9DCCD" modified="2013-06-26" version="1">MAHETTQDGFETYDKHDGDNSDMARCIDPRLRDHGAIDMSGTWTDEAGYIASMRDLELDITNGQLLGGYQTTWQQDSIRSAPQSPLDFEDTVYTEVHNSQPLWPTELMQHHETPYHANAIASTSPTNQPYTPPSSNSARTARHRSDGMVATVFGAQQHATLPQLRLVTSEPQTFAPRITQPIPGDGCPTPTSTRSAQTSIESPLYTNTPSRPPRAGLSVGVSMSLLTFDAFVHHQEQEQHPVSAVSVQHWRDDIRSKTNQGQTLQPPPLHHQTQSAPASIVQSQTSYTCDVCGSTFGRNADLQHHRRNHGDRVHGCGACDASFVFRKDLRRHAGSVHQEQASFFCEYEDCKHRAQGFKRKDHWKRHMKGVHNWAFPPSRHTSNASRSSRHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDX7</accession>
    <name>N1PDX7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_37854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDX7"/>
    <dbReference type="STRING" id="675120.N1PDX7"/>
    <dbReference type="HOGENOM" id="CLU_605536_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109034" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="48383" checksum="AE1F2A2DF85B1676" modified="2013-06-26" version="1">MIVGWTALAPIAAAAGTYCSEAPYSALVPLGTLPGVQSLCSKFYPPTSITTTTTLTSATTITSTASTTVTQSTITETTTTTQTSTVFVPAQERKRDSDLESLDARSAASGHCSPGVVAGTRCTAQCGTDRPGGDYNHKNCSCFTECDKLCSQDSKCTNIDYHRDMSICYFKASKTPAKPNSNNDDAVCRQAPDASTTVSTTTTTTTTNPLVSITNMPASKIASFCSCVEITPTSTVTISTTQSSSTTITMTITPDATTTTTTATTTSTTQVACPAPSLAQCGKSSPIPSSSDPCAFIRRKTLLDCFRLHTSNHEQTVFNKPLQCKQNAFCSNGSCTKYNNLDQCRDPGQQCNNPGQTCYCYETTDTYNVLKEALTDAQGEMNWVLTMKFNLVTCLRTVPHHHTIPETILATIEPQHAQTTNSAHDVNDPSSAHNASVTEFQDQRPMIPKRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE46</accession>
    <name>N1PE46_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_91213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE46"/>
    <dbReference type="STRING" id="675120.N1PE46"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OMA" id="TWHHRVQ"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME39850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="306" mass="33744" checksum="7841B85134B721AB" modified="2013-06-26" version="1">MGSIPPKVTQRTYKLNTGAEIPAIGLGTWQSPPGQVEKAVEAALKHGYRHIDTAAAYGNEAEVGTGWKVSGVPRDQFFLTTKLNNPDQGRVAEACDASLKRLGTDYVDLFLMHWPQPVDPSDATGKKALENWDFKETWAEMQKLVATGKVKAIGVSNFSKHHLEELFADPSFKITPAVNQVEVHPCYPSFKLVDYNTAKGIHTTAYSCLGSTDSPLYKNDTLASIAEKKGKTVQQVLLQWGLSRGYSVIPKSTSPSRIEANFALDGWSLDNDEIRTISSIKDRFKVCDGTFLPYDGKEAKLFIDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFE4</accession>
    <name>N1PFE4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_138054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="6">Nucleus and/or cytoplasm.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFE4"/>
    <dbReference type="STRING" id="675120.N1PFE4"/>
    <dbReference type="eggNOG" id="KOG1914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007630_1_1_1"/>
    <dbReference type="OMA" id="VQLWSVY"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="8">
        <location>
            <begin position="124"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="515"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME40295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="915" mass="102389" checksum="0E00B2FF2948AD2B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFF1</accession>
    <name>N1PFF1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_113746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFF1"/>
    <dbReference type="STRING" id="675120.N1PFF1"/>
    <dbReference type="eggNOG" id="KOG1657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045277_11_1_1"/>
    <dbReference type="OMA" id="FLEYKHI"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="114" mass="12853" checksum="C749593C115F3FCD" modified="2013-06-26" version="1" fragment="single">MPYNNTPIAPPEEITGTASLPLARVKKIIAVDPDISACSNNAAFVITVATEMFLRHLVEHSFHQVKTENTQKPRRNIQYRDVANAVARVENLEFLSDVVPRTMTYKQFKQKQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFK5</accession>
    <name>N1PFK5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_28255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFK5"/>
    <dbReference type="HOGENOM" id="CLU_1142578_0_0_1"/>
    <dbReference type="OMA" id="KMESWGR"/>
    <dbReference type="OrthoDB" id="10617619at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="243" mass="26859" checksum="B62B65CF43B86358" modified="2013-06-26" version="1">MAPFNFNDSTVVPVRVTDEELQEGRHRVQTRERFEPLSASASPPPTSPLSSPPSTAPVKNNTEATTARSAILPLPSYLNATTPASNLLLLLDWKDLTKDALLTVAAEYTTDEVLEEVNRLRTATQPLPPPITKRQAHQKITSSLNSVAKRNEIRRRDLKAALQEARRASGCLARMNGTSCAKGGEDDEEKLGVSPREGVSMLGKVKKFRVVIDRMPAKKWEKKTVGMRSITGGRWKMESWGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFN1</accession>
    <name>N1PFN1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_36824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFN1"/>
    <dbReference type="HOGENOM" id="CLU_823927_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="337" mass="37341" checksum="78721EC409A40740" modified="2013-06-26" version="1">MSKRRFCPEGAVRTHRGTQSQVCDRPSRHQTSRSKIGCALPDAYTRGTLQNLMSFNSHLRRRFSEPGDLGWAAKEVMYKTVQGVSKPGAASELLAGHLMFAAAFVHRDQTVALRSPLERLKDFGLRVYLDTASQNDIAGDPSMRVKIPIFKISTFVFSLSLLHPTIHRPKLINLAHPHHAPSLIHIDDAWISSFHLYDTSDIIVRLVLGIAGSCNPPTEEILRRAQSPSTSPLLNPSTTITAELTFLTSSPQQGRLIAARNIDAAAACASHQEQPAVSDDQRRQSISHHIDHGFERPIIISQRGSRSHKRSPHLALEPITNDDQSSLTTNLIDRSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFW6</accession>
    <name>N1PFW6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_74525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFW6"/>
    <dbReference type="STRING" id="675120.N1PFW6"/>
    <dbReference type="eggNOG" id="KOG1763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042870_1_0_1"/>
    <dbReference type="OMA" id="GREMFYF"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="172"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="172"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME41009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="342" mass="38591" checksum="38C7155DA3879E08" modified="2013-06-26" version="1">MAPKGKQQEPKKAKSTVEDKTFGMKNKKGGAAQKQIKQIASSAAAGGTPEEKKKAAEKAQREKEKAAAEQAKREAAELFKPVQVQKVPFGVDPKTIVCQFFKKGHCEKGKKCKFSHDLDAGRKQEKKSLYTDTREEEGEDGEADPKKKDNMDDWDEEKLRQVVMSKHGNPKTTTDKVCKFFIEAVENQKYGWFWQCPNGEKCMYQHKLPPGFVLKTKEQRAAEKALMDKSPLNTLTLEDFLESERHKLTGTLTPVTPETFAKWKKERMDKKAAEEEARKLKEATGRAMFETGDWKGSDSEDDSDDDDDGGFNLEALRRETEAAREKKEAERVAAQMGETSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFY5</accession>
    <name>N1PFY5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFY5"/>
    <dbReference type="HOGENOM" id="CLU_2158306_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="111" mass="12686" checksum="8779EEA039D0BD68" modified="2013-06-26" version="1">MSEHVKTSSHRPSSFVWFIELPVIRPVRQKIRDHKRRRDVQEIVSTSTENIQKSIVEDGVTAWSDSVRSQFPRSSSLRWKKRKLTTPMSAPPTYGGFMSQSPQVGAFGAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGS3</accession>
    <name>N1PGS3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2306 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_55848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGS3"/>
    <dbReference type="STRING" id="675120.N1PGS3"/>
    <dbReference type="eggNOG" id="ENOG502RYBX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054818_0_1_1"/>
    <dbReference type="OMA" id="RHDVWSC"/>
    <dbReference type="OrthoDB" id="193478at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39441" checksum="0CD61EA7627B9650" modified="2013-06-26" version="1">MTLYKRNDHPNTFVSTIRKLCNPLGFYKGYNFILFFILAGALFGFALASSPKLNINDYFLSHAAPGEAYWYRQSIPNIGITLHLFGVIPASLLVVWQFVPVVRHKALLFHRINGYAVLLLLLVGNVGALMSARHAFGGSLAVQTAVGVLAIATATSSVLAYVNIKRLQIEQHRAWMLRTWIWAGCIVTVRLIQIAAVTIVSKIGTYQTVMPCEQIADAGGNATKYVGCQADPTGYAVVHAAFADAKRIEEVAGAFHVTFGMAIWLAFVIHVVGGEVYLHLTTAEAERLRKISYERQMERGMVSPGSAGLTSDRLGDCEPWQAPAKSEVVTRHGRTVHGVNIDGDDDDSDISKPAAVLGWDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHG8</accession>
    <name>N1PHG8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_103210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHG8"/>
    <dbReference type="STRING" id="675120.N1PHG8"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002678_42_25_1"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME41812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="55" mass="6477" checksum="F0D48648F72A2A88" modified="2013-06-26" version="1" fragment="single">FPCQSQGCEKVFDRAGDRTKHEKYHYQGRPNVCMRCGKGFHFPKDLRRHMIVHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHS2</accession>
    <name>N1PHS2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Lariat debranching enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_82544</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHS2"/>
    <dbReference type="STRING" id="675120.N1PHS2"/>
    <dbReference type="eggNOG" id="KOG2863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005893_1_0_1"/>
    <dbReference type="OMA" id="GIDDPLC"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000035">
        <property type="entry name" value="Lariat debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="396"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="271"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="341"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="552"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME41095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="605" mass="67343" checksum="969F5B23D462CEEE" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI60</accession>
    <name>N1PI60_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PI60"/>
    <dbReference type="HOGENOM" id="CLU_2849666_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="65" mass="7312" checksum="D7FE175151C94C17" modified="2013-06-26" version="1">MRVTVIRREGQKIPGDAPGSTTQAFTVASMRPRPQDVTSGKDGWLMRYNSKQCITPRLHSTTQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIP8</accession>
    <name>N1PIP8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_90276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIP8"/>
    <dbReference type="STRING" id="675120.N1PIP8"/>
    <dbReference type="eggNOG" id="ENOG502QUJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1261482_0_0_1"/>
    <dbReference type="OMA" id="DYNHANG"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME41425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="219" mass="23592" checksum="61214B13A012BAA1" modified="2013-06-26" version="1">MAQGDSSSVEHTEHATQRAQSDDYGGNPLAHQWTNNTSASTQYAAFGGAFQPAAPSLVMGPAYAYGGLCHLLAGMWEIAVGNTFGGTALSSYGDFWILVGIILTLDGFGIATAYAHTGEFYAAYGLYTLGWMILTFLLWIPSYVDAQNNPKGMSDVTLTRAGGGFGIVAAFLAWYNMFAGMADRSNSPFLIPVLHFPWSERGREARKARFEGDSNEQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIT6</accession>
    <name>N1PIT6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_176617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIT6"/>
    <dbReference type="STRING" id="675120.N1PIT6"/>
    <dbReference type="eggNOG" id="ENOG502QQCH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020809_0_0_1"/>
    <dbReference type="OMA" id="VCDFYVQ"/>
    <dbReference type="OrthoDB" id="10253390at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473">
        <property type="entry name" value="BTA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="830" mass="93365" checksum="D19126B299D146DE" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ24</accession>
    <name>N1PJ24_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MPR-like GPCR protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_73832</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ24"/>
    <dbReference type="STRING" id="675120.N1PJ24"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023075_2_0_1"/>
    <dbReference type="OMA" id="IGNACDY"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME41550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30535" checksum="889E9E03BADD85B4" modified="2013-06-26" version="1">MRDNHYIHSGYRPASNSYHKSFSSVTHLHNETVNIWSHLLGAIAAATTAIILYSTMRPRFNLATSEDVMVFACFFLGAVVCLGMSATYHTISNHSEAVAKFGNRLDYIGIVVLIWGSFVPSIYYGFGTEPGLIRVYWSMITTIGAGTLVVIMHPRFRSPEWRPFRASMFVMMGLSAIFPVLHGVQMYGLQQMEQQIGLSWLVGQGALYIAGATIYAARVPERWRPGSFDIWGSSHQIFHVLVVLAAAAHLLGLMKAFDYEHRLRSGIAGWKKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJA6</accession>
    <name>N1PJA6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_73359</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJA6"/>
    <dbReference type="STRING" id="675120.N1PJA6"/>
    <dbReference type="eggNOG" id="KOG0292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007565_1_0_1"/>
    <dbReference type="OMA" id="EMTYQKQ"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000022">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="13">
        <location>
            <begin position="349"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="15">
        <location>
            <begin position="622"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="848"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="804"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME42492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1218" mass="135791" checksum="DD3783610B715F59" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJU8</accession>
    <name>N1PJU8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_175907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJU8"/>
    <dbReference type="STRING" id="675120.N1PJU8"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_1"/>
    <dbReference type="OMA" id="PAVMRIA"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="321" mass="35161" checksum="933AF1F8F1D4619F" modified="2013-06-26" version="1">MSNGQVTPTKLPSNYAEVPYKEIKISHHPASSSEPTPVLVLTLHRPGFNNAFTDVMTDELEHFFGIASIDGRIKVIVMTGHGKMFCAGQDLNQGFKLQGNGKHETEHNHRDGGGRASLAMHNCTKPTIVAMNGHAVGVGITMTMPAVMRIAWSKAKIGFVFSQRGVVMEGCSSFFLPRLVGAARAQQLVIPGKVYPATDRRLDGLFYELCDKQEDVLPTALREAEELAVNTSTVSTFMNREMIFRGVNSAEEAHLLESRVMGAMRGKADNNEAVEAFLQKRPAKFTGTVQTDCPSVYPWFSKMHTKNPAVAEPSTTGKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJZ0</accession>
    <name>N1PJZ0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJZ0"/>
    <dbReference type="STRING" id="675120.N1PJZ0"/>
    <dbReference type="eggNOG" id="KOG0260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_741905_0_0_1"/>
    <dbReference type="OMA" id="PSESHEM"/>
    <dbReference type="OrthoDB" id="8300706at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109426" evidence="2">
        <location>
            <begin position="25"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="373" mass="39422" checksum="F08C55A52BE6B840" modified="2013-06-26" version="1">MRYATFFMAAAVTSVYAGAPGAYGDESPAPYSSSTTTTCTDEYEHQPTPYTTSSYEYSPTPYSSSSKEYKPKPYYTTSSYEHKETYAPIPPYYSHGEEKPSTYEHPPVYESTSTETETKPVYYQPTAPIYSPESPSAPIYTATASVYSPESPSAPIYTATASVYSPESPSAPIYTATASVYSPESPSAPVYSPEKPTAPIYSPESPSAPVYSPEKPTAPVYSPESPVAPAPTTCPICPAAATVTVTVTGQAPAYTPEAPKSPAPYQPEAPKSPEQPQAPSYPQKPQPYQPYKPVASQPAGSYAPAPSVPAYTKPSYPMGTGVYKPYPTGGAAYPTAGAYKPSESVTPYTGGAATYAMSGFAAVVASFAAFMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK12</accession>
    <name>N1PK12_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_134111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK12"/>
    <dbReference type="STRING" id="675120.N1PK12"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="OMA" id="RICGVTH"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="9"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME42459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="346" mass="37287" checksum="06409453F19063D1" modified="2013-06-26" version="1">MKAIKIVDGHKAELQEVPVPALRDDYILCKVHCVALNPTDWKHIDKVGKPGSTVGVDMSGMVLEIGDKVTKEWQVGDRIATFVHGGNESQKEDGAFGEFCVVKGDLGLKIPDTMSDSDAATLGTGVITCGQGLYQSLGLPLPGDGMEKYGGFLLVYGGSTATGTLAIQYGVLSGCRVITTASEQNHPLLKALGAEECFDYKDPACAKKIRDYTNDDLRKVFDCISEGSSPKICEESISSQGGTISYLLKAKHTREDVENKRTLGYTIIGEAFVKGGNKMEAKPEDFEHAKKFSELTQKLVNAGQLAVHPAEVGQDGLKGVFEGLERLRKGEVSGKKLVYRVAQTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKE5</accession>
    <name>N1PKE5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_36423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKE5"/>
    <dbReference type="HOGENOM" id="CLU_1337487_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="205" mass="22497" checksum="D310A2EA6B2344E0" modified="2013-06-26" version="1">MATSTGFQLQRAPSRLMHVTVQGLKCAVLSEQTWDKDPARLQKVSSITHPLSKTAKLDNDRISNELQLLYRDLKSTLDAGIAKHINNAIIRGRLESYMEMLHKPQPPQHNPTVSDAASEEAQDINDGRQTSELKVYTDDTGRPQEPVSSESRRSISGAAPDPPAPLQRKGSETPMVPSSTGPKDEKAASDMLFTEPMTYTPAAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKS7</accession>
    <name>N1PKS7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_25799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKS7"/>
    <dbReference type="STRING" id="675120.N1PKS7"/>
    <dbReference type="eggNOG" id="ENOG502R9ZK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_994063_0_0_1"/>
    <dbReference type="OMA" id="EGWERLF"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="29991" checksum="AED253556ED98F31" modified="2013-06-26" version="1">MAALEVLQAGQLGFVSPAESDLLEYNISEPVNITWRTPYSLTTVEVWQGPFDNGAYSTDVLVANATQRQSSISWNAISFSGSDLNTPLFFRLQKGETPNTCELCTKDSAAFRVINSGESSTSSSSSSPESMTSASSTASAVASTTSPLATAATSIESNDSALRIGLGVGLGLGLGLLLLLTVMALVLLRRRRKRQEAAARRAEALKSESAVRDSLASGWTSKHSDKTMSGMSTSGMSYHSRFEFEMPDGSIREGWERLFGPDGRVTYQKIPTKPGQAVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL37</accession>
    <name>N1PL37_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DWNN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_73173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL37"/>
    <dbReference type="STRING" id="675120.N1PL37"/>
    <dbReference type="eggNOG" id="KOG0314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019105_1_0_1"/>
    <dbReference type="OMA" id="NVPDHEP"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="558"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME42260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="65964" checksum="F5D559A893EBE5C0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL43</accession>
    <name>N1PL43_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL43"/>
    <dbReference type="HOGENOM" id="CLU_2359709_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108867" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10555" checksum="0D86DE88F3059B12" modified="2013-06-26" version="1">MRGKGLRIAVAMLLHIRHLVFQIGALRSCISCGGPFLRHSGLFNRPEMSRSLAKPVSIAILGVSDVKALPDTENPNDSGLVQFRRRVDCVQQRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLI7</accession>
    <name>N1PLI7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_44468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLI7"/>
    <dbReference type="HOGENOM" id="CLU_2831175_0_0_1"/>
    <dbReference type="OrthoDB" id="3912985at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="66" mass="7437" checksum="5D5960A243702AE8" modified="2013-06-26" version="1">MQSPRRAPSNENSDSYNSRPHAPSDGYNFVNQHAAEDFQAQSRFVAEAPNDREIALADSIPLYKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM04</accession>
    <name>N1PM04_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM04"/>
    <dbReference type="eggNOG" id="ENOG502R915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_782022_0_0_1"/>
    <dbReference type="OMA" id="IEHHTIC"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="333" mass="38175" checksum="575A8F6B38FDEB1D" modified="2013-06-26" version="1">MSTTPLHATHERHDSAVVDSYDGLPKLLPKTPNSTSSSPQCAFLSLPPDIRNMIYDLVFHCPDGILIDFTHSYHLGLGTLPSLASTCRQIYDESHDLPYWLNTFHFRLPVFRDLQALRAISPSMLKFPLPARDPSPRRLIRPADEKGSELRFVTMAMRDPHLEEIMQNFEEVVGQWRVTNRLRKVHVDLGSITNNTFLERVFHAWEEVAPRLAALSGSMRIGSETRLIFRLRLSKRFIVDYDFTLRERMATMREMDACVSRGAFDVEEFTLPELGTINAMRKRVWDTFFVSGLPGEDSLPPRLSRSFSSVEGESREQTLQRPLDEHSMLVMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMN1</accession>
    <name>N1PMN1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_72198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMN1"/>
    <dbReference type="STRING" id="675120.N1PMN1"/>
    <dbReference type="eggNOG" id="KOG0647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038526_1_0_1"/>
    <dbReference type="OMA" id="EAMDQSI"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000190">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="118"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME44662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="39702" checksum="CEBBA382942F063C" modified="2013-06-26" version="1">MAGLFGSASSTASSANANPTQGDLSQDKAIQEPPSDSISDIRFSPKSDHLAASSWDNKVRIYEIDGQGQSRAVTAFDHEGPALNTCWSGDGTKVFGAGADKAARMLDLAANGAAAQQVAAHDQPIRCVESFMHNNAPMLVTGSWDKTIKYWDLRTPNPVASVECRDRVYAMSMRNDQMLVVGTAERHTHVVDLRNPGQFYKTIQSPLKWQTRTVSCFIDGSGYAVGSIEGRCAIQYVEEKDSPSNFSFKCHRQTPPNDRNVSNVYAVNAISFHPQHGTFSTAGADGTFHFWDKDAKHRLKGYPEVGGTISTTDFNSSGTIFAYAVSYDWSKGYTGNTQNYPNKIMLHPVVGDECKPRPKTGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMV2</accession>
    <name>N1PMV2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_53059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMV2"/>
    <dbReference type="eggNOG" id="ENOG502TIFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_602727_0_0_1"/>
    <dbReference type="OMA" id="ISLEAWW"/>
    <dbReference type="OrthoDB" id="10618944at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="454" mass="48767" checksum="22B2682F3D09A8E5" modified="2013-06-26" version="1">MSAYSARLTNRKVTKLVSDLLKELRKKYPAEEFPVAHEQDPKNTLDKQYLAIEAKNIIIAAITADCYSLGLTKNKTIGLPDPADCEAGFQISLEAWWPEGSDDGGVVGLAADKQANVLADVAFTRLMYLANKNLPRADANRLKDLADANDESLFLEQTGPQPLSELEATLPAPAKVSKDFRLSSDWPGYPSAGTVTNEVSNLGQAQYSITADIIFETIKVEVAKAKTKASKAYVRTDNEDARALATDIDAQPIYFPIITAFISLPGNKLCKRAGKNVLDMAHSFAQYVQDEENNFNQAYYGDGPALFSRKLAEIPAEDLGAFYVVASKQYSATKVAEEIAAGGEDLDDGATVNSAATPSLADSASLLGDGDELDTEFQVAPNIDPPARRARGRIGRGNTDRRSAAAVPSDSDEEIEEAGAGSAKATGKRGREDDSDEDSDIAESSSKAAKKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN76</accession>
    <name>N1PN76_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN76"/>
    <dbReference type="HOGENOM" id="CLU_1713207_0_0_1"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17149" checksum="4115AB768238BD84" modified="2013-06-26" version="1">MMDTMWSGTTTSATDSTPLLRSTKEVKEHLQSTVEYLRQCANDRTLTQARDSFDPDFIAVVAPPHKLTLDEYINHLELVAHFKPNVYIKCDGMSTVIDAQKGSARVFMDFEISGVYEGVVRSSVGVFKFRYGEDGKWRLVHYEATDGVSGMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNW6</accession>
    <name>N1PNW6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_72158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNW6"/>
    <dbReference type="STRING" id="675120.N1PNW6"/>
    <dbReference type="eggNOG" id="ENOG502RZ3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070319_1_1_1"/>
    <dbReference type="OMA" id="DPHSLQM"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="7">
        <location>
            <begin position="147"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="7"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME44608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="286" mass="30570" checksum="51B21EA7BFC02183" modified="2013-06-26" version="1">MGSFIEKIKAKLPGHHGDKKDATESTTASPAPASTQATAPAPTPAAAPKTAASTGRPKVLFVLTSHDKMGDTDNPTGWYLPEFAHPYYKLAPHAEITIASPKGGEAPLDPSSVEMFKEDAESTRFLKEKEALWKNTEKLELFVGRETEFDAIFYVGGHGPMFDLATDQTSHSLIRTFYESNRIVSAVCHGPAALANAKLSDGSYLVAGKDVTGFTNVEEDQVGLSSVMPFLLESKLVENGGQFVQATEPWGAKVVNSGLEGRLITGQNPNSAGPVGEAILKALERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP15</accession>
    <name>N1PP15_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_127893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP15"/>
    <dbReference type="STRING" id="675120.N1PP15"/>
    <dbReference type="eggNOG" id="KOG4114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138069_0_0_1"/>
    <dbReference type="OMA" id="GNMPVTY"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13892" checksum="F150CF9514B01C39" modified="2013-06-26" version="1">MPSSCKDIRAALAQCLQNSDCMLIHRNSASDCIRPPLKDDLPTQCQQLIHGYGQCKRGMVDMRKRFRGNKPISTSTELEGDGRSPMLYAGKGIDDQVKEIKEREKEGYESFTRNDGIEGLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP19</accession>
    <name>N1PP19_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 64 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_62617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP19"/>
    <dbReference type="eggNOG" id="ENOG502SJJ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032886_0_0_1"/>
    <dbReference type="OMA" id="QYPAGWV"/>
    <dbReference type="OrthoDB" id="10058186at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09220">
        <property type="entry name" value="GH64-GluB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.50">
        <property type="entry name" value="Beta-1,3-glucanase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042517">
        <property type="entry name" value="Glyco_hydro_64_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165:SF1">
        <property type="entry name" value="GLUCANASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52006">
        <property type="entry name" value="GH64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109497" evidence="1">
        <location>
            <begin position="21"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="GH64" evidence="2">
        <location>
            <begin position="76"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="454" mass="47554" checksum="6B40801A559DAA2F" modified="2013-06-26" version="1">MHSFFTAFLAATYIVGTALAAPVVHRANDATPVMPGGVQDLVITKENTLNATSSQPVTNSTTGARAKGNILSVQANSRLPLALVNNMGGAVNAYVTGLDPSGKVVFVQSNGQFYYPPCDASYTTPREVTGPIAIPLNTAQGSTVTVTLPDYISSARIWFAQGSLHFYSVWNPATNSPSQVQPSFANPQDPSAGINWGFVELTNNSGGLYANLSFVDFVGLALGMSMRAGSGVTTTVRGLRTGSVSTICNALQSQQSSDGQPWASLCQSDGNGPLRVVAPNIYVSSGNGAFSNYFTSYIDQVWSQYTSNTLTISTQSGAGNVACRVSGSTLTCDGDNRAYNKPTVGDIWGCNSGTFAIQGGDNDVHRAVVPRLCAAFNRGTLFVNGGNTQPGPAASEYYTTSPNNQYSRIVHQQEVDGRGYAFSYDDVNPSGGVDQSGTLADGNPQLLTVYVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPV1</accession>
    <name>N1PPV1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_24489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPV1"/>
    <dbReference type="HOGENOM" id="CLU_924448_0_0_1"/>
    <dbReference type="OrthoDB" id="5416609at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33352" checksum="B5B16A07DF0CD52D" modified="2013-06-26" version="1">MLPHAPGIDSRHEHFLAVDYNKPVFDVYVDFAKYCIEAGLGLEILGYVCAPAASQIDYRPPPVAGEHAFPSWTPDWRIPNRIRPLNSTGLLHGEYRVLYDPCPKTKVAAVVSGLELGIQGFVFDTINSIVTTSGRQEIPVSNVLATWSAELASTYGPIEKERFWKLVLADAYQIESEETGLTANARGGGESRHLMGMDPASLDYAYIWVRSQMHHALRGVCRDRRAGYTEAKRLAILPEAAVPGDLVAAFHGGHTLYVVRPIAREEKYTFVGECYVEDMMDGEVMTLATENGIVPQTLWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPW7</accession>
    <name>N1PPW7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPW7"/>
    <dbReference type="HOGENOM" id="CLU_2372776_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="95" mass="10761" checksum="F2C582559A26E56A" modified="2013-06-26" version="1">MSSGARRTEWRSVSPTPSGSKTQRRLRRLGIPNCTHNGGRCKPSCRVVEMFNEQSKTYSSTARAKLLSSRRYSSRRTEPTRPSVLWNGAVDEFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPX4</accession>
    <name>N1PPX4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc knuckle-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPX4"/>
    <dbReference type="eggNOG" id="ENOG502S7VK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062858_0_0_1"/>
    <dbReference type="OMA" id="HYSYECT"/>
    <dbReference type="OrthoDB" id="437973at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29531" checksum="4E310AF399D9CB15" modified="2013-06-26" version="1">MNRYRTGTLSQASATTTCQKCLKKGHYSYECTASKQDRPYVSRPSRSQQFSNPKLAPKLSAVLPPADPKPEVKNPGLVLEDSRSRKHSREEPTRTSAPKRRRSVLSYSSDSVSTISTSQSRSRSNSPPRDSRRRISVYREAPPRDERRRRGSSTGSRRRPSRPDSRTQSEQSPVDSRQRTGSSLRSSRKRSISPTRRDVRRSRSRSPYRGGSQHAMASRSRLDDEQIAQPPRRPAAPPEPARLRSLSPYSQRVAMTRAGNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ43</accession>
    <name>N1PQ43_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_172810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ43"/>
    <dbReference type="STRING" id="675120.N1PQ43"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OMA" id="NIWHAYH"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME44544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="513" mass="57517" checksum="AC0F930AEF4C92D8" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQK3</accession>
    <name>N1PQK3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="5">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_150963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="5"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQK3"/>
    <dbReference type="STRING" id="675120.N1PQK3"/>
    <dbReference type="eggNOG" id="KOG3124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_1_1_1"/>
    <dbReference type="OMA" id="VWAVKPQ"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="7">
        <location>
            <begin position="199"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="4"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME45731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="300" mass="31005" checksum="772375C895B81EE3" modified="2013-06-26" version="1">MAVLGCGTMGTAVLGGILQSLQSQSEQSAAASYAMSSAEPAPQRPPSKFHACVHSAAGAERVRSALSKYNARLKIHQSSNVDAAKDADIVLLACDTHVVASILQADGMREALAGTLLISICAGLSETVLQDIIYGRDFTTSLADSHACRIVRAMPNTAAAIRESMTMIATPEPPLDAERDTLLTWIFTRIGRVTRLPAANMDACTALCGSGTAFAAVMVESMAAGAIGTGMPREQAYTMAAQTVRGATGLLLQGEHPAVLRDQVSTPGGCTTVGLAALEEGGFRGTIAKAIRNATSAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR93</accession>
    <name>N1PR93_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_52311</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR93"/>
    <dbReference type="STRING" id="675120.N1PR93"/>
    <dbReference type="eggNOG" id="KOG3492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097217_0_0_1"/>
    <dbReference type="OMA" id="LISMGTC"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="103"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME44885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="190" mass="21157" checksum="AB62F3C3DBD1A096" modified="2013-06-26" version="1">MRPLTDTETKTLFEKLANYTGRSLNNLLTDTASTPNAKTTDRYVFRVQKDRVYYVRESLANLATSVARDSLLSLGTCLGKFTKTGKFRLHITALDVIAPHARYKVWVKQNGEMPFLYGGHVVKAHVGRWSEDAPEHAGAIVMSMNDTPLGFGVTARSTAEARKLDPTGIVVFRQADVGEYLREEDTLFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRB4</accession>
    <name>N1PRB4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_115416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRB4"/>
    <dbReference type="HOGENOM" id="CLU_1953909_0_0_1"/>
    <dbReference type="OrthoDB" id="2788050at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="129" mass="14694" checksum="3F10982CE31C6439" modified="2013-06-26" version="1" fragment="single">ELERMAAAAEVRDTDNIEQAVSLRQSIFGYSFWEVEQQVLQQRSDLTSTVAQDLWESVREEQEILGHDREPYSNWPNLARRPRPTVLPSQSALTSRGVLDREYIFKLGVLVTSAHVLQDIAGLPHPPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRD7</accession>
    <name>N1PRD7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_43416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRD7"/>
    <dbReference type="eggNOG" id="ENOG502SPD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117282_0_0_1"/>
    <dbReference type="OMA" id="WPAYTDV"/>
    <dbReference type="OrthoDB" id="5352317at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110080" description="Small secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15197" checksum="A356F090366A68FC" modified="2013-06-26" version="1">MQFTSVLALLSAVAVPALAAPAADPATTNMMASGPQWTVQNFKRTCGGGVCTYDYSVLQNGQATKCNYQVKGSPATRASYNNVQCGPYVISSSWSGQFGDGNGFQTLAVVNGKQIIYPAYTDKQLVSGQVVTPDQSYTPQNLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT24</accession>
    <name>N1PT24_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_71281</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT24"/>
    <dbReference type="STRING" id="675120.N1PT24"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="OMA" id="CFDDYPE"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000822">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="81"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="344"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME45520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="401" mass="46266" checksum="B94E3168F12CC70E" modified="2013-06-26" version="1">MAPAVVSNIASRFHRMSHSQDNDSHNSSRDSRQSNAQREEEKTRLASWEAEKHPLEPDEIVKDPQTKPVGHSSKVLRKEDFELVKTLGTGTFARVWLVKLANRKERDNNKVFALKILRKPDVIRLKQVEHVRNERNVLAAVAGHPFITTMVASFQDDTTLYMLLDYCPGGEVFSYLRRARRFNESTSQFYAAEIVLILEFLHEREGVAYRDLKPENILIDAEGHLKLVDFGFAKKIESRETYTLCGTPEYLAPEVIRNTGHGTAVDWWAFGILIYEFLVGQPPFWDQNPMKIYEQIVEGKVRYPSAMSKDARDIIGGLCTVDVSKRLGNVKGGANSVKQHPWFQSINWDDLYHRRMRGPIVPHLKGADDTRNFDEYDAEPKERDEYTKEMRDKYDRAFADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT25</accession>
    <name>N1PT25_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_128644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT25"/>
    <dbReference type="STRING" id="675120.N1PT25"/>
    <dbReference type="eggNOG" id="ENOG502S6W3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_81_3_1"/>
    <dbReference type="OMA" id="MCHGSPY"/>
    <dbReference type="OrthoDB" id="2447880at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="entry name" value="DNA Methylphosphotriester Repair Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="Ada DNA repair protein, N-terminal domain (N-Ada 10)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="87"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME45564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="134" mass="15261" checksum="66B8BDD977978BB3" modified="2013-06-26" version="1" fragment="single">MAYGYATEATRWAAIRDRDAHAEGFFVYCVKTTKIFCRPTCKARLCRRSNVEFCETNAEAQAAGYRACKRCKPELANFVPEADQSIENVRRMLEQLPQDAVLPKLDALAASAGLTKYHFHRCFKKPTGMTPREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTI4</accession>
    <name>N1PTI4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTI4"/>
    <dbReference type="STRING" id="675120.N1PTI4"/>
    <dbReference type="eggNOG" id="ENOG502TMS4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1462201_0_0_1"/>
    <dbReference type="OMA" id="WHERGIG"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="201" mass="22423" checksum="3A78986331CBBA5A" modified="2013-06-26" version="1">MLRVIWRYACAAGHVNYSMRARLSRSLCSTTRPDEINSNDISRGHIWKTYAGKFAVGVSQGLTKGRRLEDAGICGTSPKSEEHLVSLASHTVAGRGREQEKARHAALLQFMQDDLKEVNNCMPVEPLSKMLAKAYATDIVWKEESHLGLPKALSTHRGPNDMFARMLREGINVHMRAGDFTRRARDWEAPGAIAALLAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTQ7</accession>
    <name>N1PTQ7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_78969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTQ7"/>
    <dbReference type="HOGENOM" id="CLU_857953_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="324" mass="35493" checksum="F989A82ABCF02023" modified="2013-06-26" version="1">MPLHHFQNFHLGLCLTPWDDKPEDVDSPGEEERKIAALALTGPTLWPPNDGTPDHYQTTRDRRGQYHTRRGWAASCVLWRKAAKASGAGGGKPASPLSVGWLDKHASSRGATIVFGLPRSSHRPLRLPRGQESNGRRSPRWSVGASWSSGYDRLASTAYMPVHSTSSSHRVLLQLYARGQLSVGSRSPELALKLAQTRMYTSAAKRWYNASSIQSRSSSVEDDKRLRTKSVCATDSVRDVHSAHGTWKLPRGTTGVRSGIDIDWKLFREGERSCGSGRLEGNAVEKHARGLAQGPQALRASYSKLGFPTAPSSNNDIDYAATIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTZ0</accession>
    <name>N1PTZ0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTZ0"/>
    <dbReference type="STRING" id="675120.N1PTZ0"/>
    <dbReference type="HOGENOM" id="CLU_1408730_0_0_1"/>
    <dbReference type="OrthoDB" id="3635333at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="193" mass="21919" checksum="4ADC53440F73C0AC" modified="2013-06-26" version="1">MSWASIRTTSRIEDTASCLMGLFSVNMPLIYGERMDASTRLQLEIIKHSDDESIFAWAGEPNIGSSRANKYQPRGSLLASHPRLFESSREIYRIDRVSGKPYAMTNKGLRLGADAAIIGYGVDKFYVILINCAHGKFIRLDNEYRMKGVTPCLLVLQRLNHNMFGRSRYELDLETHHDGAWLSNPFSDEVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU30</accession>
    <name>N1PU30_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_71528</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU30"/>
    <dbReference type="STRING" id="675120.N1PU30"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034009_0_0_1"/>
    <dbReference type="OMA" id="SFYTKDV"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="126"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="402"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME45860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="467" mass="53534" checksum="623BC0A57F412DEB" modified="2013-06-26" version="1">MSPRNRGSIYVARFIPALLVLIVGYVSWVIVGPLSIDYLINPPKDSDGNLVRPRRVAVGLAIIIVYFVLLLPVAATWLRLLVTVLKDPGYIPQGPEQERRASEPHPSINDFWQRDVFVCDPNGSPIWCAHCRNWKPDRTHHSQDVGRCTRKMDHFCPWVGGVVGERALKFFIQFLVYTMILTCYLTTVLAYWVARRKGNVHWYVALGLAGFFLLFTLGMVMNSLNFVFKNVTTIENVSRRMYLAVVLPPEKQIDPTMPPPPTKDDDSDRPTTSELDHPAHLNYFSRQSRSGIQAHSPDPVPPKKSKIWKGTITYPLHLPVDRPPLPAPQPRTFAILHTPPGLNPWDMGSSYINFKQVFGERLHDWIFPLKHSPCCDHTLHISEFPLGPEFELLLMDAGLVQREKPHKKDRRPSSSHNGKRKRRLDVGWKDGERPDGWVSEKEARRIRNEWRRRANQGQLGQHPPEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU86</accession>
    <name>N1PU86_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_20842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU86"/>
    <dbReference type="STRING" id="675120.N1PU86"/>
    <dbReference type="eggNOG" id="ENOG502RV5M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1348893_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="203" mass="21626" checksum="410F8DBB58E28062" modified="2013-06-26" version="1">MGHHMRMPRGRCEPHSVSKRYTTYSHILLKTSTSRERILNTCYIHHIVFCAPAPGSQALTAGQAKASDCYPDRLAYTDVGYRNSFVDTAACFAIFRKNTKPLASGFVSFTTAIGITLQHRGDIYRDVAICNASAIDPFGKSGVSLVPFIAGSAGRNIGWNSTIDGAVGLFAGAGTFNDPSGSLSAPNLLTVTVSIHSPGPDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUG7</accession>
    <name>N1PUG7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUG7"/>
    <dbReference type="HOGENOM" id="CLU_2483329_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="87" mass="9838" checksum="2DA9B3E70F670532" modified="2013-06-26" version="1">MSSCWKDTTSALEPYRSEIWSAIECNLMSSGIARARPSIHDLYRMVGSHDIESISSRSVPKNAPRCDGSPRDARPIIHCPRRHVQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUP7</accession>
    <name>N1PUP7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_50652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUP7"/>
    <dbReference type="STRING" id="675120.N1PUP7"/>
    <dbReference type="eggNOG" id="ENOG502S522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109915_3_0_1"/>
    <dbReference type="OMA" id="ITTIFWF"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME47201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="168" mass="18448" checksum="42A2C58015887C09" modified="2013-06-26" version="1">MAIWDSRAVVLGLRITQASFAIIVLGLAAYVVNWWSGYWHASSPDSMNFLVFCAVWTILALLYLIMVPWRFSETGAHHPIIFTTVEALTMIFWFAGFIAAAVFLSDRVCFGSVCSAAKAATVFGAFLWILFAFTTALAVTTIGRRGRGIGSNHHHNKADPKFNVAEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW69</accession>
    <name>N1PW69_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA recombination and repair protein Rad51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_33187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW69"/>
    <dbReference type="STRING" id="675120.N1PW69"/>
    <dbReference type="eggNOG" id="KOG2859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046729_0_0_1"/>
    <dbReference type="OMA" id="TAFFWQD"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19490">
        <property type="entry name" value="XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030547">
        <property type="entry name" value="XRCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39431" checksum="7495DCD479954429" modified="2013-06-26" version="1">MSAEDLGKKLLAEVEEVGLDEILNYLRLRDDASLSIFGLSALDSMIHVLNVARTSSGRPQPTLPIIELMTLRPDTGTSELLHHLIARSVLSTNLGGHQSCAIVIDADNTFSVSRLTHSIKHFAFSNRQPETTSESLNQAIHHSLKHIHIFHPQSLSSTIATLNALPSYLFDAKRHTSFDRPISFIALDSASSFYWQARSSSEDAALLANTSKTSAMSSEGYTHLAVALKRASRVLHAPILYTTRYIGPRKNHSTGFEMEARSFRPSLPPPWGTMPTVRLMVRRVEVRKLPVGATVEQARREDEARRKVVEKAKFEVFVNEWGIDEGTVRRLQAREADAFAFFAGREGFRKEVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW71</accession>
    <name>N1PW71_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW71"/>
    <dbReference type="eggNOG" id="ENOG502RVY1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_739726_0_0_1"/>
    <dbReference type="OMA" id="EGHTWHE"/>
    <dbReference type="OrthoDB" id="3633490at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="374" mass="41472" checksum="40FF8A3EA08834AA" modified="2013-06-26" version="1">MSLSSLKRKANSPPENPPVRKKSSVSVLAAAAAYGGSIKVAKKGRPGPALRESTSNLALAKIDRGEALKEFGPWEKASTVNNRGRTLRRRESVLTGHGTPLRPGLELAGSQLQTMKGEDIASIKEVLLLPTSLAVIKPNWPFCFDINCTPQLGPALPELIAEDLYQKYVCSSPLLRPGRLPYYHIGTTTIGFRLHFYLVLPNAGGPPHAANTGHLSDEVLQRLFDHCICPALQAAEPKRRGFASWMQAMNEANLKPLKSRKRSAGPEMQEERIHCFHLTSIWEAIEACDDEDVQDLLQGGMLVAYGDVEGHTWHEGWKPTWASWRKDWEGAVEKRFLREESRISVGIDLGVGVSEEGRKGDGKMSRYERNRARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXE9</accession>
    <name>N1PXE9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_31578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXE9"/>
    <dbReference type="STRING" id="675120.N1PXE9"/>
    <dbReference type="HOGENOM" id="CLU_756553_0_0_1"/>
    <dbReference type="OMA" id="WNNGKSA"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109165" evidence="2">
        <location>
            <begin position="17"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="366" mass="40846" checksum="2EFF0736CC04A3FD" modified="2013-06-26" version="1">MTVLHILLIILGMIMAAFQWSAPGDVEDEGIVFGDYQHLWHGYRTSPALSPHPDARRQAEHGTGPEIIQTLKYCFVDERPHKNLGKILTQAIAKWAHAMTVSSLRSDLAPSAGGDPMRYCSELDKSDMDTLAIEDVTRDGDADWNNGKSAQSSGAGDVEDKPRRCATETTTGYTYIDSKAGEMGGNHRHTLNLCMRDPDNPPAGESEEWHEAAMQSAFSTKYQRPDRDEYLWIRWKNLEGFAEMQAAVKTDERGILDNPYDSDDSGHSAFEGYDQRTREYEARAEEHAAAAAYFPIAPDYIKGDHYNYEPKKSEFASYAFSSKFDYDSIMIYSSTMATPAGSTKYSITRKTGNGLQPVWMGVSSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXX6</accession>
    <name>N1PXX6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alcohol O-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.84</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alcohol O-acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_78324</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aliphatic alcohol + acetyl-CoA = an acetyl ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:17229"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:47622"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.84" evidence="6"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXX6"/>
    <dbReference type="STRING" id="675120.N1PXX6"/>
    <dbReference type="eggNOG" id="KOG1838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032487_1_0_1"/>
    <dbReference type="OMA" id="MMTTSWG"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004026">
        <property type="term" value="F:alcohol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000137">
        <property type="entry name" value="EEB1p Acyl-coenzymeA:ethanol O-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="147"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME48282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="465" mass="51768" checksum="AE9B2B3E0294768A" modified="2013-06-26" version="1">MAFTWYPGHQSITYTHSETPLLLPTKTGPKRALPEIIKDITPECYLNPFLFNGHLQTAYTAVKMAGPAIHYKRRVFEQEDNNFPGHFTVDFVVAPPPKANAEARDGGLDDQGLREDPMGVGHHRLPPRTTYFTDKEFSNLGSDDSKPLLVTLHGLSGGSYENYLRQVLEPLVRSTPEGEKAGGISSGEWEAFVVNSRGCAGSKITSSMLYNARATWDVRQMVKWARKQWPNRKIFGIGYSLGANILTNYLGEEGDKCILSAAVIVSNPWKLEPGSLSLQRSWIGLEVYSKTMGKSMLALFDTHKEQILKNKSISYDGMHKLKYLHEFDRAVQCATWGYPTEGAYYRDASSADSVMAIRIPTLCVHAKDDPIAIDEGVPYEEIKQNPYVVMLATSGGGHLSWFQFGGARWHSKPIVGFFNVMAGDVDFDHVEKPEVAGHGPHGGIQSPFAFDPMRRKQYIADSPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXX8</accession>
    <name>N1PXX8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 12 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_41573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXX8"/>
    <dbReference type="STRING" id="675120.N1PXX8"/>
    <dbReference type="eggNOG" id="ENOG502SRGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063917_0_0_1"/>
    <dbReference type="OMA" id="SFNNNAW"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF11">
        <property type="entry name" value="CONCANAVALIN A-LIKE LECTIN_GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="287" mass="31182" checksum="E50E302732D7426B" modified="2013-06-26" version="1">MTVNNNAWNQDDSGGICTFVCGASPRDVVSFFSLWNWTSSPPAVHAYPNAELRSDLLPLRLGDLLSLQVSASWAFGPATLSEDARNPNSPEDSTYIQSNNVQANVVLDIFADEDAERSRTPSEQKYEFMVWVGQFGAAAQPVGILTPREPPVVVRVDKTDFTLWNGTKSTGQYVYSWLANETLTNFDMDFAPLLGFLVKEEGVSESLYMGTIQFGHETFLAASQMNFSISSYAANVQSIVAEPNSTLAPTASLPVATSVSGASKGVRPRVGWCGTLWLSIVLFLTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZ69</accession>
    <name>N1PZ69_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_67771</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZ69"/>
    <dbReference type="STRING" id="675120.N1PZ69"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031986_1_0_1"/>
    <dbReference type="OMA" id="PYAPKHQ"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000646">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000630">
        <property type="entry name" value="Zinc finger protein 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME48826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="414" mass="43866" checksum="947D5FAE4435BBAD" modified="2013-06-26" version="1">MGPGSDPIGGPTVYTRRPNAPDLPAVQLPPPQFNSMNPYNKPAYQPSTTLTSVGNLLTPPSNSSADGISPSSGVLSNAPLSSHGAGQAYTPHGTGGMWPPPSTTGSTPYGYGASGTPVSFPSGRGIFSPSLNSIVSGSRSPTASEGLPPPPYEIPQYSQSMPMSAPTSYSQSQGYNPGVHVQSTPVSAPVTQASPVSAQDSFARPPPTPTYYPQHSSTSSQGGYSYSGPSPVQQSPMSSNPLKMSPLNQHGPVPSLQSQPPQQYTHNRPYSYPMNQPVLSNVANPNGQLALVGGGMPHGMMPGFNSGHAAQMHQLYGHHPQQQNVQNDRPFRCDQCPQSFNRNHDLKRHKRIHLAVKPFPCGHCDKSFSRKDALKRHVLVKGCGNKSATAEVKEIDPSQSPEPKSESTGHSPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZR5</accession>
    <name>N1PZR5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GPI transamidase component PIG-S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_49301</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZR5"/>
    <dbReference type="STRING" id="675120.N1PZR5"/>
    <dbReference type="eggNOG" id="KOG2459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010026_3_1_1"/>
    <dbReference type="OMA" id="AEHKYAV"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME48927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="58540" checksum="C914D725645B9A28" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q081</accession>
    <name>N1Q081_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_76547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q081"/>
    <dbReference type="eggNOG" id="ENOG502R99X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_557790_0_0_1"/>
    <dbReference type="OMA" id="EFHFQEE"/>
    <dbReference type="OrthoDB" id="3649817at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="2">
        <location>
            <begin position="51"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="489" mass="55305" checksum="1EE51BCE7A265F28" modified="2013-06-26" version="1">MPPPLLVSHAGSRLPMSHLYHNFSSLTSPSIHVRSPRPRTTYNEGTCNMELFRAYSDQSHGLNNKDLFAPGAAISSGNTIRYTAPSPTATNLAQELTDALAWNKSKPSIFIFFTTSLLFATQVGRYRKQQNETNVHITCLNTKTARTPGGNPVKFWSVACLIKTHGTALTNKDGSIRDYTDVYVATDCVDPGRDALTASFNEMEAAGLYRLYPAMVSGYRSHRPRLALTTQDLREFHFQEERSLTAGQINAAAEVAAAFTRNSISETPQVSRSMSIHVLALRKRRTNDVVLTSWIQNCSIEVVDPDGDEDELSITDFLHDLPEIEQCRKLRLVFANRQIIGTALGRGIGVSKVAQEQELAEWQIWRRENIAKHREAREKRPDYVPERSSRKRHRHEQDDSEDVVDCVQQRYEPTLQPARLRRAGDRAARDASRSSRIEAMPYSFSGRDGCNARSEMPGFETRALHGRGERHRGDRSSNHERPAKRTRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q113</accession>
    <name>N1Q113_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q113"/>
    <dbReference type="STRING" id="675120.N1Q113"/>
    <dbReference type="eggNOG" id="ENOG502S63K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024462_1_0_1"/>
    <dbReference type="OMA" id="RHNWSRG"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25499">
        <property type="entry name" value="Beta-prop_pof12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="567" mass="62436" checksum="44322A714ACFD731" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1T6</accession>
    <name>N1Q1T6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_68103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1T6"/>
    <dbReference type="STRING" id="675120.N1Q1T6"/>
    <dbReference type="eggNOG" id="ENOG502S404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_647271_0_0_1"/>
    <dbReference type="OMA" id="DDPEQRC"/>
    <dbReference type="OrthoDB" id="4150019at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME49223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="424" mass="46562" checksum="88BBC4C5B071C1F2" modified="2013-06-26" version="1">MPSSDSSQHDHSPTTTTRLSDDAVSAPQKHLTSARANAHSASGAPLPDRKKARPLQTRPGKHPSESFSTPPLRGPTMSESELDKKRNKLGYQRISIACAHCRRRKIRCLLAEDDPEQRCQNCIRLKKECVFYPVDQQTALDARSEASSRTGEASAPSSAVTTSPPHLIVRSFDQQNHQYGGGYHHMPSDAPGGYGIPIPATAALSPQNGYVPQSYGYAVQREPATAWNHQQQQMGTHTQPTPVGTTGNIAPPFVRYEATSNAGDTAPFPGSSDQQSPAVQQHPAGYSFTPEPMQQQWPPPPQQQQQQQQQQQQQQQQQHQQQQQQQQVRQPPRFLAHTTTAVLFHAAHSRSATPRWAANHGFALSGGTVIRPLCLPDATRPAQPEHSDHGRLSSPCNTNAAAALVFWWVGAVRTRRPGQSRARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1W4</accession>
    <name>N1Q1W4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_67500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1W4"/>
    <dbReference type="HOGENOM" id="CLU_2885739_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="63" mass="6860" checksum="BB106778FEFBCBD7" modified="2013-06-26" version="1">MMGMLNQLGSIPKRQAASAPSADNPSRVSTSPSKRRKRSDGAPTEDGSVKKSRQQSRSEREET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2E5</accession>
    <name>N1Q2E5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Versicolorin reductase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dothistromin biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_49054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2E5"/>
    <dbReference type="STRING" id="675120.N1Q2E5"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="NAGICSP"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME48614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="285" mass="30834" checksum="EE3213FC4CDBEF57" modified="2013-06-26" version="1">MPGRLRDRIALITGASSGLGRSTSLLFASEGAKICCVDLYDRPRNATNATTQKSDDFHNRIEGESTVTELQRLHGQDRAIFIKADVTKADDVEAAVAECVRTYGRLDILLPNAGVSVESTHSQPHGIHELCEADWDLTMSINVKGVFLCCKYGIAQMLKQDLLPGTKSRGWIVNTASVQGLVAYHNTPAYTASKGAVVQLTKQIALDYAPYRIHVNAIAPGFLRTIMTQNLQNSPEKQAEIDKAHPFGGMGSTEDVARAALFLASDDVAWITGVSLPVDGGYTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2M0</accession>
    <name>N1Q2M0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2M0"/>
    <dbReference type="eggNOG" id="ENOG502T16X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106352_0_0_1"/>
    <dbReference type="OMA" id="QTSYLAM"/>
    <dbReference type="OrthoDB" id="5429002at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109527" evidence="2">
        <location>
            <begin position="18"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="185" mass="17427" checksum="A9802405BA28C944" modified="2013-06-26" version="1">MRYSVLALAPFVAAAYGQETSSSATPTVTSTYTYSNTETNFLSSTNSYGVITGMPSLTDTGAPVAATSQPAVDTDVGAAASIPAGLPTGIQTIYHGGSNTSTSFFLVSVGSSTTVVVQSSTSSASATGGSAGSGSGATGASGSAGQSASGTGSASASSSSSAADAVKIVSGAVLGLGAAVVVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2V0</accession>
    <name>N1Q2V0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_68813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2V0"/>
    <dbReference type="STRING" id="675120.N1Q2V0"/>
    <dbReference type="eggNOG" id="KOG2588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008057_1_0_1"/>
    <dbReference type="OMA" id="WVYSEQQ"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11399">
        <property type="entry name" value="bHLHzip_scHMS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019006">
        <property type="entry name" value="Sre1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09427">
        <property type="entry name" value="DUF2014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="238"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="296"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME50076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="982" mass="106199" checksum="7BF68E93FDFBB15F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3N2</accession>
    <name>N1Q3N2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_67927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3N2"/>
    <dbReference type="STRING" id="675120.N1Q3N2"/>
    <dbReference type="eggNOG" id="KOG3003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_0_0_1"/>
    <dbReference type="OMA" id="PHRHQAI"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="246" mass="28087" checksum="FFCBCA35599D21FE" modified="2013-06-26" version="1">MLQQRLARSLQQMVRQPRPLPRPTVQSTPCYAATSKVAPATSEQLLGRRWYSEATKESEKTEEQMLKENSGEQDVKASKDGEKEDPVQKELEAKKREVIDVTDRLKRQVAEYRNLQEQTKREVAAAKDFALQKFAKDLLDSVDNLDRALENVPKEKLTDENKDLVNLHSGLKMTETILMSTLKKHGMERIDPSAENEPFDPNKHEATFQAPQPDKKDGSVFYTQQKGFMYNNRVLRAAKVGVVKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q431</accession>
    <name>N1Q431_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q431"/>
    <dbReference type="HOGENOM" id="CLU_1825233_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="141" mass="15478" checksum="4ED044A3B1CEE7D7" modified="2013-06-26" version="1">MQTLHDELSRFSLDSHRSSFDQAAYDDQYEDEDDDLDITAELQGGNGNTKDGYRCRLNTARAIRAPDIAGPSRVHVPRAPDTTGARPIKPVPGLRYGDIEMGNIEIGMSRDVSGITLTPSVTKPRGCWQAFVHAMTGMSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q504</accession>
    <name>N1Q504_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_50058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q504"/>
    <dbReference type="STRING" id="675120.N1Q504"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_20_1"/>
    <dbReference type="OMA" id="LNEPICY"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="5">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="286"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="328"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="370"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="486"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="525" mass="57134" checksum="A76FF9D4FC690801" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q535</accession>
    <name>N1Q535_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q535"/>
    <dbReference type="STRING" id="675120.N1Q535"/>
    <dbReference type="eggNOG" id="KOG3104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037043_1_1_1"/>
    <dbReference type="OMA" id="GCDLWTV"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000004">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="375" mass="42652" checksum="86C9DF7E7F95FBAD" modified="2013-06-26" version="1">MKYLPVREVDTVTNALNFSTPDTHVIGGCDIYTTKAAGTDKKLYREIENSLESQYESLVRLSASLSPPYRTASDDGKASDKSGRSRRGRTAEPAPEIDLSRASPFGPLSQITARRTFAYLIATLNASHPDYDFSHILRPSDFRKERSLRTVMHNIDSTLQNLRPKHTAAQNYLSPPSLSHSTPAGFNSGNDIWSQNMWKLIDKEMGLRHCEKYSYNPEEDPFDGEEGAIWSMHYFFFNKEKRRVCYLYLRGFSVISHSPVHAATELRPRSAPRKVSSLSVGEGAGKRASFWLSNDYLQRSVDTVSYGEDDDDEMIIEGPDDDEVEVPFMTLDDLRNDLADGRYYPISEEDENEDWHPRHVRGLSEEISETMELDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q536</accession>
    <name>N1Q536_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_41120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q536"/>
    <dbReference type="HOGENOM" id="CLU_2158285_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME49979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="111" mass="12591" checksum="4F51619CD75CED14" modified="2013-06-26" version="1">MLPESDPAVLLMLRRWQQEWLGKVQPLDFIWQLLDATGAKGDSARIGILLEGGHDDIFDVNVFACMHPEQQSGRICTRTEGGEALISLEPRLRQLLTAALEWTLELFDRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2WHM5</accession>
    <name>M2WHM5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_29693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WHM5"/>
    <dbReference type="eggNOG" id="ENOG502R9QT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_537500_0_0_1"/>
    <dbReference type="OMA" id="ITTWDES"/>
    <dbReference type="OrthoDB" id="3646116at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57079" checksum="372AAFE82B892D47" modified="2013-05-01" version="1">MPIINVPGVGPPRVSTAGLREFRRSQYDPRDLSLFRRHDHFANTSLDESGPVLPPPQLRHRAPTDMQARQDALSHRGAREEAEDEDRRERTAGHSADCKAVRLDSWRNGNEPFRRVLTTAIKLWKQTGAPDALAFEKHLTNAMLAADKEKTVYDIAGWFPNLPHNIHFPLRDVCKRLHGEARMMYELVEKEDEAGGMVASSNIHPELPRGTCCTIVDVRRSNSGVESVRVDEYPNFGTDPDHLASLDALDSFDPPHALATTLTPRQTLIRIRAQLETRSMLLQPRANTRFETTSTNRLHITYLKDGVDKAALQQAFARYGNAPHSFINRPQSSNTPTSEPASAVVAFEHAHEAARAHVEHPNATIEGQAIKIAHVTPDASRTTTWEESIDYALYRWCLYALNYVKGKLDDCDRAPSSIADGRLIASVHNQIKAFCKLHNFGKIAYMEAVDEEHDNKVVMNDDASSTPELRAELDQMEEQLEIFEEEFGAGILGQDWRMSQRSRRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2WNJ5</accession>
    <name>M2WNJ5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease III</fullName>
            <ecNumber evidence="2">3.1.26.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_131512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="2"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WNJ5"/>
    <dbReference type="STRING" id="675120.M2WNJ5"/>
    <dbReference type="eggNOG" id="KOG1817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048162_0_0_1"/>
    <dbReference type="OMA" id="WIMELYI"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034963">
        <property type="term" value="P:box C/D sno(s)RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000001">
        <property type="entry name" value="Ribonuclease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME43583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="293" mass="32832" checksum="4BA223725FF71999" modified="2013-05-01" version="1" fragment="single">FPQLPPVASEKLRSAVFKHKSIYSQHRDGGDGIVTYEKLEYLGDAYLELFASRLIYHRFPNLSAGHMSRDRETLVKNETLAQFSRAYGFDAKVEVDKSVKTQMEQDKANKGFNKVLGDVFEAYVAAVCLSHEDGFAAAEKWLTALWAPKIIELYHAHRTLIHPDDADPLTLFDPNATEELSRRLGSGKGCKLDYTPVTTIEMKGDQLGQNLWIVQLRLTGYGHTSRLLATAKGANQKEAKAWAAIKAMHGETKSVIEECEVKCQAAKSRRIAQKEMEKESQDKQPSDSVKTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2XGD7</accession>
    <name>M2XGD7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_39668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XGD7"/>
    <dbReference type="HOGENOM" id="CLU_392788_0_0_1"/>
    <dbReference type="OrthoDB" id="10586592at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="702" mass="77718" checksum="B02AEC06E284ED00" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2XI73</accession>
    <name>M2XI73_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XI73"/>
    <dbReference type="STRING" id="675120.M2XI73"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064330_0_2_1"/>
    <dbReference type="OMA" id="PFMRETP"/>
    <dbReference type="OrthoDB" id="3647333at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="322" mass="35199" checksum="2F26EA4D14081A09" modified="2013-05-01" version="1">METSRTIGDAEMQRILFSDDPPLGELPVFEPIEYSQSSDDEETTQSLISLDPKTRAVEAACKAGNADRAFADVQHLLQTGTNPQDFQVCLIAAASSGQEGLAQMLLSAGVPASQWAVKAAIKQDSIPLLSLLIKNGWNINEEEAWCLPPLLSFAIHTKASESTIAWFLSNGADPNATCQMDVTPLSVAVAVARYSVVEQLFAHCPTTTVFRGQLLHHAAGRDVPEDCDMILRLVLRRCRPDINAIMYQDHYFSYEVHKIVGLGTALYEAARTGRLSTIKTLIAHGADISIRDSLGYTALDVAEREHNLPVIEELRRLEAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2XJE6</accession>
    <name>M2XJE6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_75291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XJE6"/>
    <dbReference type="STRING" id="675120.M2XJE6"/>
    <dbReference type="eggNOG" id="KOG1003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104738_0_1_1"/>
    <dbReference type="OMA" id="EQWETKY"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070648">
        <property type="term" value="C:formin-nucleated actin cable"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990819">
        <property type="term" value="C:mating projection actin fusion focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003786">
        <property type="term" value="F:actin lateral binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000114">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18575" checksum="F3B2E9C589177F83" modified="2013-05-01" version="1">MDTIKKRMNALRIEADESAAKVEELSTKVKTLEQENLSKEQEITSLQHKNSVLEQDVEKFEKLHGEAKAAADESAQHGSQNDALQRKLQLLEEEAEENDKQLRETNEKLRQTDVKAGHYERKVQALEASRDQWETKYEEMAKKYADTKKELDDFVAEIGNI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-09-18" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2XJV1</accession>
    <name>TFC7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hps1-dma1 cluster transcription factor tfc7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">tfc7</name>
        <name type="ORF">DOTSEDRAFT_83206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2019" name="Fungal Biol." volume="123" first="397" last="407">
            <title>Evolutionary relics dominate the small number of secondary metabolism genes in the hemibiotrophic fungus Dothistroma septosporum.</title>
            <authorList>
                <person name="Ozturk I.K."/>
                <person name="Dupont P.Y."/>
                <person name="Chettri P."/>
                <person name="McDougal R."/>
                <person name="Boehl O.J."/>
                <person name="Cox R.J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="31053329"/>
            <dbReference type="DOI" id="10.1016/j.funbio.2019.02.006"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor that regulates the expression of the hps1-dma1 gene cluster that probably mediates the biosynthesis a derivative of cyclopiazonic acid (CPA) (Probable). Further studies are required to whether the CPA-like hps1-dma1 cluster is functional or a non-functional relic reflecting evolution of D.septosporum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XJV1"/>
    <dbReference type="SMR" id="M2XJV1"/>
    <dbReference type="EnsemblFungi" id="EME39732">
        <property type="protein sequence ID" value="EME39732"/>
        <property type="gene ID" value="DOTSEDRAFT_83206"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RJXM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035265_0_0_1"/>
    <dbReference type="OMA" id="VIRESCN"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000447728" description="Hps1-dma1 cluster transcription factor tfc7">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="31053329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="31053329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="381" mass="41464" checksum="4F927B811FA7510B" modified="2013-05-01" version="1">MSTIKYRAACDHCSATKIKCTQERPQCTRCRALGRDCHYSRSLRAGKPPRSSQGLNRKISNAPVLPRQNTPVSNPTSMSSKPEHWPTMPTSYPTPQAAAPTAEIFHFPDLSSAATSSSSSPANTDWFFDFNSGSADGLGDLTPPLVVTAPHLPPLDHDLKHPVFPTQGIHFGAFADLISLPPASPLLPSPSLADGDRCAKLATETLNSLYDMPANHLHGSGNRHPSVDQTLSTCARAVQAIHELVNCSCQKDLYLPMLIIIVASKIVAWYQAVAYIRDPGTGFADGKQCFREVVVEGPLNIGAYQLDDEVGWTLKNQIVLGQLQRLNEAVNIYDRRYCSDSLGGQMTEGGKLYASMVGFVKSTLQFTIHALEGRIRSGHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKL4</accession>
    <name>M2XKL4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_173641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKL4"/>
    <dbReference type="eggNOG" id="ENOG502SI9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018249_1_0_1"/>
    <dbReference type="OMA" id="HAYMDSG"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF9">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004029307" description="ASST-domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="60643" checksum="423F74EBD4F7C8D7" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKT6</accession>
    <name>M2XKT6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_132434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKT6"/>
    <dbReference type="STRING" id="675120.M2XKT6"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_2_1_1"/>
    <dbReference type="OMA" id="DYHGYRR"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="3"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME43117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="271" mass="30649" checksum="F00D3AD6DFAAB0F0" modified="2013-05-01" version="1">MHVRQIAGSLGAEISGVDLRSVTEKQTREIRQKWLDNKVIFIRRQDLDPDAYLSFASTIGKPSPYPMVPGIQGYPEITHVLKREHEKTNFGGIWHSDTVYLDTPPMATMLLARELPPFGGDTLFANQVAAYDALSDGLKKTLSTLTCVHTSSKAAASKTREDRTNDTGYKAEELVSYHPAVRTHPETGKQSLYLNVAHTDRFDGWSAEESAPLLHYLHQHQVKPEFTCRFQWQVGDVAIWDNRVVLHNPINDYHGYRRSMHRITLAGDKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2XZH6</accession>
    <name>M2XZH6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_48794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XZH6"/>
    <dbReference type="HOGENOM" id="CLU_1686528_0_0_1"/>
    <dbReference type="OrthoDB" id="2266637at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="18620" checksum="0A10F25AD602DEE6" modified="2013-05-01" version="1">MGRRLANWQQRDIQRLFDKTSRSNQDIANSLNIARRIVDKYRNNYLLFGAIYYEIGTFNRGPRHPRALLPIVEEHSYISRLLKAWNWSRKVAIRLTKERNEEYLLLYSLDFNPIELLFSVLKNWVKRHISDASIYENFGAFIRIAIKQFETVDARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y058</accession>
    <name>M2Y058_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_92051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y058"/>
    <dbReference type="eggNOG" id="ENOG502T8B2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127770_2_0_1"/>
    <dbReference type="OMA" id="CISAYDF"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.110">
        <property type="entry name" value="Protein of unknown function DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466:SF1">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="114" mass="12659" checksum="2272857BD6541019" modified="2013-05-01" version="1">MSDQKNVHGTTLTQHTLNAGFHKDGFCRTSPNDKRNLTIAATLTHSFLQCEYGDDDYKGLKAGDKTCISAYDFRQAIKEMGPDTAPKVDLNATHDKALNVIGLDELKKYAGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y188</accession>
    <name>M2Y188_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_29248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y188"/>
    <dbReference type="STRING" id="675120.M2Y188"/>
    <dbReference type="eggNOG" id="ENOG502QTX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_1_1_1"/>
    <dbReference type="OMA" id="IVSTNCW"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="416" mass="44925" checksum="914C6B8FD2549738" modified="2013-05-01" version="1">MARLRVLIAGASIAGPATAYWLSKLDADITVIERFPALRSEGGQAVDIRTVGVSVMRKIPGMEQAVRDKRAPIEGIRFIDSQGRDYGTIGATGKSEQQGLVSEYEIFRGDLSEILYDLTRDHPRVKYIFDTQISAITQDEKKGTADVTFTNGIPPETFDLVVDCSGATSHTRAIGLSYGKRDHVIPAHSWAAYFSTKTDFLSGSRIGHGVSIPGGLMLAVGQDGKGANKVTLMGVGEASTTAFREAQANGDKALRAFLKEKYENGGWICKDVCEEMLSSTDFYASEIVQVKLPSLHRGRFVLVGDAGHATGPTGFGTSAALVAAYILAGEISKSLTNIDAALDAYEAQMKPLLAEMQKIPPFVQTIMAPQTGWGIWTRNTVFWVLARTGLVDFVQIKLAGAFGSGEETVVPEYEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y1F1</accession>
    <name>M2Y1F1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_75028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y1F1"/>
    <dbReference type="eggNOG" id="ENOG502QRF9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029538_5_2_1"/>
    <dbReference type="OMA" id="EGCTIQN"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME39134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="42428" checksum="600A7121778C3A35" modified="2013-05-01" version="1">MSRPSTASNSTTAQVLPPKQDPWYAAPPNYEYAAPGTILKVRPAVGNITSVQSNSTAAYNILYRTTNSQYNATWAVTTLFVPSTSDGNDKLLSYQIPYDSVDLNSSPSYALYSSPYSDIVNALGQGWYVNVPDYEGPKASFTAGVMSGHATLDAVRAVLASGFGLNTTSAKYAMWGYSGGALASEWAAELQNQYAPELNFAGAALGGLTPNVTSVMMAVSGTIEAGLIPAGILGLASQYPELQQYLMDNLKTSGQYNATAFYEATNYTLIEEIVAYAGQNITDYFNNGLATLSDPIPRRVINRDGIMGYHGVPQMPVFAYKAIMDEVSPINDTDILVDRYCLIGATIKYDRNTVGSHTTESANGDARAVSFLTSVLGGTYNATGCQIQNVTVNGTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y1V7</accession>
    <name>M2Y1V7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_179759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y1V7"/>
    <dbReference type="HOGENOM" id="CLU_2483328_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="87" mass="9718" checksum="6AFE345A32B837A7" modified="2013-05-01" version="1">MELPTNIVSKLTGKSDLEDKIKELEKRIEVKDIERDAWVSAVEGLKIQLANALDEIKRLKSESQEEKITEQRSDNAGEAHGGNGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y265</accession>
    <name>M2Y265_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_47922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y265"/>
    <dbReference type="STRING" id="675120.M2Y265"/>
    <dbReference type="eggNOG" id="ENOG502SFH4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042426_1_0_1"/>
    <dbReference type="OMA" id="FLKCMQL"/>
    <dbReference type="OrthoDB" id="5405654at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="299" mass="31623" checksum="7203218A72E7DDAB" modified="2013-05-01" version="1">MASATATATMAAAGFNKKARDSAASSLQTPGSGTFPSEMLSPMAPSPSFKKREDALKTPITPPSAYLDFLKNYSSTGLMSPAPTGTSSRFSFNDHSFDKSSDKASEVAKSSMTPPTSQPALSRNTSYDSNGTDQSNTSSTGGATAQLRRGSRPDSPRIIIPPSTFAKPAPRSARTPRRLAIPQSPFSPALGSALTTASMPSPYSSTPLSAAPWSASFSPREHSDAINQPGKVHVRHVVTRTVTYCRTPLVEPAPRGKRRKLDTDEADSKASSHKASSEEPSIKQERIEEVVTESSSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y2D8</accession>
    <name>M2Y2D8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase family 76 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_56842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y2D8"/>
    <dbReference type="STRING" id="675120.M2Y2D8"/>
    <dbReference type="eggNOG" id="ENOG502S9QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028686_0_0_1"/>
    <dbReference type="OMA" id="KNAISIW"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF1">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="593" mass="65518" checksum="7B153DCEC025FDA4" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y398</accession>
    <name>M2Y398_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_88860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y398"/>
    <dbReference type="STRING" id="675120.M2Y398"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OMA" id="IWASKCR"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF317">
        <property type="entry name" value="ADENYLATE-FORMING ENZYME AFEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="88"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="498"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME42809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="593" mass="66565" checksum="54BD943E8F782BF8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJ49</accession>
    <name>M2YJ49_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_75617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJ49"/>
    <dbReference type="STRING" id="675120.M2YJ49"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_0_3_1"/>
    <dbReference type="OMA" id="DQVLMDH"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000009">
        <property type="entry name" value="Heat shock protein Hsp70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="498"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME38975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="591" mass="62881" checksum="07AC4AA8993BCBDF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKE0</accession>
    <name>M2YKE0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_47944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKE0"/>
    <dbReference type="HOGENOM" id="CLU_3014121_0_0_1"/>
    <dbReference type="OrthoDB" id="9971592at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="56" mass="6353" checksum="34E8B2A0DFDC1955" modified="2013-05-01" version="1">MAPARLLYVLPLNGLHCIAFWKMAYSQSPCCMLKNRLGELFGGRHRDLDVYAIVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKQ8</accession>
    <name>M2YKQ8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_75276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKQ8"/>
    <dbReference type="STRING" id="675120.M2YKQ8"/>
    <dbReference type="eggNOG" id="ENOG502RHJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_9_0_1"/>
    <dbReference type="OMA" id="PQGRMTT"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME39556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="358" mass="38228" checksum="4010417EFA960CC0" modified="2013-05-01" version="1">MEQVKQLKVDYPWTQAPLVSCGPMRLVALASLATEVSRAGGLGFLGAGSDVSTLGEELEKAKQLQAGAQALREVTEVMPIGIGFLLWAGEKLLTDALPLIEKYKPAAVWLFAPNESSQFEQWTREVRRVTNRRTKIWIQIGTVKDALEVAKTCQPDVLVVQGQDAGGHGLQEAAGLVALLPEVDEAVSALCSSEKLNKPVLTAAGGIMDGRGAAAAIALGAFGVTLGTRYLVAPESNIAKGYRDAVLAASDGGVNTARGKLYDTLRGTKDWPERFGGRGVLNETWHDAQQGMSLEENQKLYDEAMKQGDAGWGASARLTTYAGAGVGLANSIKSAARITEEVRDDAKRILKQTSKYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2YL44</accession>
    <name>M2YL44_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_56924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YL44"/>
    <dbReference type="STRING" id="675120.M2YL44"/>
    <dbReference type="eggNOG" id="KOG0299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014017_1_0_1"/>
    <dbReference type="OMA" id="CSLRIWK"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME39590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="599" mass="66167" checksum="DD6C146A1D607ED6" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2YL89</accession>
    <name>M2YL89_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_114585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YL89"/>
    <dbReference type="STRING" id="675120.M2YL89"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048469_0_0_1"/>
    <dbReference type="OMA" id="HRADGPM"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="237" mass="27457" checksum="4CD165756ADE969D" modified="2013-05-01" version="1" fragment="single">DEDDGYYLGTRVMAYQLLHSNSAGTNNSVPFLVLCTCDVSKRKRDRLKADGATIVLVERLDPGWIASGQERWRDVMTKLRLFQLIEYSKICFIDADVLITAPLDGVFFDEATLTQATLPSPANIKEDEGPLPRTYMFATHADYWGYDHPYPPTTDLDYLNCGFFVFTPSLVLFDYYLSLIKVPGRFDPQFPEQNLLNYAHRRDGNMPWKVLWYGWNVNWPTEKDWRGGARSFHAKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLD7</accession>
    <name>M2YLD7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_53823</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.M2YLD7"/>
    <dbReference type="eggNOG" id="KOG1035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001222_2_0_1"/>
    <dbReference type="OMA" id="FEDIAWD"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000660">
        <property type="entry name" value="Ser/Thr_PK_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="15">
        <location>
            <begin position="39"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="237"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="555"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="185"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="666"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1415"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1420"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="775"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="561"/>
            <end position="569"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME42826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1558" mass="174733" checksum="25260E002F508993" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLE9</accession>
    <name>M2YLE9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_72324</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLE9"/>
    <dbReference type="STRING" id="675120.M2YLE9"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023861_0_0_1"/>
    <dbReference type="OMA" id="ICEAQEH"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="59"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME42836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="450" mass="50426" checksum="2C74EA955469A18F" modified="2013-05-01" version="1">MAARQGIGLLLRLSPSIRVRAYATAAAGIGQGNASQKIVPPPWRPSNILDEWVQREARPISLRQLTFFGRSLTEDRLITSANYARLELPTRIAHRLRNMQTLPYSALTNQHISHVYELYYQAFERFRKVSAVRTLEDNDKYCEVLKQTLKDHLTVIPRLAMGILEIQDTVAGEECDRFMTHLLRSRISRRVIAEQHLALTETFHSPWHFPDAKKTGGAEDEFVGEIFLKCNAQEIIGKCAATARELSQQAYGPHVTIPEIVLQGHMNTTFPYIPSHLEYILGELLRNSIQAMVEQRGLNDPPPVEVLVCEAAQHVIIRVSDQGGGVDRSILPYLWSFAKGPRRSNRLENLGRVPRLAATMQELQVPCSAVDVSSRPQEKRPDASLASLSGRPPDLKLGMGLPMSKIYAEYWAGSLEVHSLEGYGCDAFLQISRLGNRNETLSTRAAMDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2YPS4</accession>
    <name>M2YPS4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartyl aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_72857</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YPS4"/>
    <dbReference type="STRING" id="675120.M2YPS4"/>
    <dbReference type="eggNOG" id="KOG2596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_348159_0_0_1"/>
    <dbReference type="OMA" id="WDIKPEG"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF4">
        <property type="entry name" value="VACUOLAR AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="254"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME43626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="87942" checksum="B895500F440D33AA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBF4</accession>
    <name>N1PBF4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_75704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBF4"/>
    <dbReference type="eggNOG" id="ENOG502S6BM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021768_3_2_1"/>
    <dbReference type="OMA" id="WRRISPW"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109690" description="non-specific serine/threonine protein kinase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="5">
        <location>
            <begin position="181"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME38212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="263" mass="29783" checksum="2BF69BC34BCEEE4E" modified="2013-06-26" version="1">MLLTLRLWLGCRIYGTVGDPRMPAGVRVGRKRMIKLNCKTPEVEALSYVAANTTFPCPKVHRIHRYRGKLAIELDFLPACRNLLNCWRQLSTDEQRGVVEDVSTFVQQLRALPFKDPHRISSTSGGPCRSVRISSSSLCGPFDHSAAFHECLRGGLTLEGNDSTFGDAVSRVHNRSYIVKFTHGDLAAQNILVRGGKVVAIVDWECAGWYPEYWEYTSAHYNYVLLPEFYDKLSAASDRYDEELKAERELWKILDQPLDQISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBT4</accession>
    <name>N1PBT4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_27715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBT4"/>
    <dbReference type="STRING" id="675120.N1PBT4"/>
    <dbReference type="eggNOG" id="ENOG502SFZQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056399_2_1_1"/>
    <dbReference type="OMA" id="NYSPPSC"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37434" checksum="3E71438ED2DC02F5" modified="2013-06-26" version="1">MSVYSGSTLEADISSAKMDLRHSFKCVTQSRPIRFLIGPNNESYFVHPALISKHTSALNARIDGITGPPTKVRIVLSDLEEDTWVNFLEYIYLGYYTPVEHTIIKEIYSDHEDDLDSEAEVTPPTTVDETEPVPESWLEPVLDPGFGFGSKSKKKGRKTTHAAWDMLDSVPLPVDPAPAKLSKPEGSKQGKTWAAFQARHFEVVVPSLPLSARANRSHLEDYTCVFLGHAKLFVLATSWGVEHLPELALRGLHETLVNFTLYHERTVDIARLLEYCYNGTWVEQDGHSRLQDLVMDFVACNITKLIDNDGFQDVLRADNSAGVALMKKLVKHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBX7</accession>
    <name>N1PBX7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_74680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBX7"/>
    <dbReference type="STRING" id="675120.N1PBX7"/>
    <dbReference type="eggNOG" id="ENOG502SISJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025894_2_1_1"/>
    <dbReference type="OMA" id="HATFWVY"/>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="26"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="511" mass="55859" checksum="1D8047132BB0336E" modified="2013-06-26" version="1">MAAVARPFLWFYHEFGLDSVHASGRNAWLIILARSLRMFAYGTNALILALFFSEVGFSDSRIGLFMTLTLAGDVILGTFLTLIADRVGRRKILFGGSFLMVLTGVVFAYFENFWILLFAAVIGVVSATGGDFGPFRTIEESVLSQLTTPKTRSDVLAWYVTLSALGSTLGSEASGRIIEYLQSFDGWNLADAYHSLFWIYAVMGVVNAILVLLLTNACEADPRQEKYAQVPQDEAEDHSIELVDSPVSINTARPALPAPESKANSWLAWLFSWMGNISTPTLAIVWKLWVLLAIDSLADGMVPYSLTNYYMDSKFHPSKATLGDLTSISYFLTAIGGIFAGPLARKIGLVNTMVFTHIPSSAAVLVFPLPQVLWGTAILLFLRAGLNNMDQAPRAALIAGVVKPEERTAVMGITAMMRTLAATAGPMVTGFLAGSNRFWIAFVAGGAFRLTYDIGLWVIFVNVKLNQHEPAGPEMRQSTTQERRQSQDDADIASLASSDVDDDDDENVRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCA1</accession>
    <name>N1PCA1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ABC transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_47539</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCA1"/>
    <dbReference type="STRING" id="675120.N1PCA1"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OMA" id="IRIRMLK"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000240">
        <property type="entry name" value="ABC transporter B family member 20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="744"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="817"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="849"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="964"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="51"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="376"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="706"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1029"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="625"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME40073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1271" mass="138582" checksum="31822F306434E500" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCG1</accession>
    <name>N1PCG1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_38152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCG1"/>
    <dbReference type="HOGENOM" id="CLU_1184982_0_0_1"/>
    <dbReference type="OrthoDB" id="10569999at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26685" checksum="5BA2B981A0CC59FC" modified="2013-06-26" version="1">MRQALRSRIMPPKVRQQGLRAYTQRDLVLLDHKLLSRGFLDYKADQACPSKPSQTRKTFSSLPGEIHNKIYTLIESECDVEVITWTTPLTLAARFAQVSRRIRREYLPIYHQHRHIHLTLPRGARRVSSETRNWLSVFGASRLPLAETVSIYSHRARFAAHFRGGGYEVETALFRKSALVMGHSVPATMLKKAMEEVIELGVEVREDGRPVMTMELLGQSIDIFARVGGKSSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCP8</accession>
    <name>N1PCP8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCP8"/>
    <dbReference type="STRING" id="675120.N1PCP8"/>
    <dbReference type="eggNOG" id="ENOG502SNVG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_681502_0_0_1"/>
    <dbReference type="OMA" id="QRTYRHR"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF3">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="47446" checksum="AD01C2C861E91A52" modified="2013-06-26" version="1">MPPSRTTRAVTDDDDWQHITDQALRKRAQNRLAQRKHRRIVGEKLKVLERLTERQDHPQQHALWSFPAGFPSQNSSPVHDRRPNAASDPPTTATSESSRLNHTPDPTSPDAHPAAQISQRYDNGNPATNANETSFGVQSNQQSFPWPQGHHPGDHAASKSMGSDAANMLGAQNLLYDSTTTNGASHSCHSDSCNSSVRLNRCITQQNYPPNYFDMPTSSLLDPGLRHGSASQFGGGDVFAPSIGAMGEYHSPSTTASVDRDSQKANSSISPSASVGTRLESAVQAIRPLGFDSIDELAAQYYTADLQHRPVLSHIRQLSRRRGLTELLRAIREDARDNWTEWEVQRYRDEVLRAAEEILDDEFSQFTKLSGHDSKPNETLAERKRLFQAELPNLSSLLSGLGLSVDLQGNGDRASTTVYAINTLLHGIGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCX6</accession>
    <name>N1PCX6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_56423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCX6"/>
    <dbReference type="STRING" id="675120.N1PCX6"/>
    <dbReference type="eggNOG" id="KOG3252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076723_0_1_1"/>
    <dbReference type="OMA" id="GDDLCAD"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000389">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="46"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME40162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="243" mass="27462" checksum="C886F8A9CF3AF069" modified="2013-06-26" version="1">MGVAFDYSPDRPENIDAILNGLDRYNPETTAVFQEYVAGQCESQTYDCYANLALLKLYQFNPHLTRDESAINILVKSLTVFPSPDFSLALALLPPHVLRPVPEKSGPPSSGSLSEAVQHLSALHETLNNAQYAQFWEILSDDDIYADLTADVLGFEDTMRVRIAVVVSQCMQEVGRQVLEGWLNLRGEKFETFVKEVCGWKIEGEKVRVPLNKENEARSVVQRETVKFDQFSRMVKRAYEQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD96</accession>
    <name>N1PD96_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_74810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD96"/>
    <dbReference type="STRING" id="675120.N1PD96"/>
    <dbReference type="eggNOG" id="ENOG502QRIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_5_0_1"/>
    <dbReference type="OMA" id="MISYRTH"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME40069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="315" mass="35744" checksum="C006E41B2206847C" modified="2013-06-26" version="1">MGGMHVLEFAYFGADYVRTIVAIATSAQSSAWNISWGEAQRQSIFADRKYNDGYYHLDDPPACGLGAARMSALLTYRSRDSFECRFGRRKRDRQQVHECDDLSRRRRTMISGEEQHFLAHNEGHISVRGPRPNDDPPPAPHTHPSGDAKVLEHAERRLATIYSAQSYLRYQSEKFIKRFDANCYIAITHKLDTHDVARDRASNMQAALAMIQQPALIIGIKSDGLFTYREQCELADMIPNGHLKTVHSPEGHDGFLLEHDQINLFLTEFIQRELSHIRSTQAAVQFKESRSKAYHTTGSMLSTWGMGARAKCTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDB8</accession>
    <name>N1PDB8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_74975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDB8"/>
    <dbReference type="STRING" id="675120.N1PDB8"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_2_1"/>
    <dbReference type="OMA" id="DMVNIEE"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001423">
        <property type="entry name" value="Ras family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="233" mass="26419" checksum="E5C5E55256035E71" modified="2013-06-26" version="1">MGDAHKISITVCGDGGCGKSSITLRLVRSQWTHEYDPTIEDSYSVTRTIDGTTYQLNLTDTAGQEEYRGLWSSSNLTSDAFLLVYDITQQSSLQALDYFNQLIDMEKENRVERGAVLPVCIVAGNKCDLQGIRQVPAREGLDWARGLGYGFMETSAREMVNIEETFALLVRRVIQARKAHSEGVMNLPNSTARTRPLEPIASLNNEKALPPDPKWDDHEQMPKERWWHKLRCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PED8</accession>
    <name>N1PED8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_29553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PED8"/>
    <dbReference type="HOGENOM" id="CLU_3087201_0_0_1"/>
    <dbReference type="OMA" id="IYGADSH"/>
    <dbReference type="OrthoDB" id="10297803at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="52" mass="5666" checksum="3BEDB8EAC5A2D9E4" modified="2013-06-26" version="1">MPSDTEHPRESLGDEVEDVIHGADNHSEEGHGKDVPISEEIEDAIEGGQKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFA8</accession>
    <name>N1PFA8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_27646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFA8"/>
    <dbReference type="HOGENOM" id="CLU_287847_0_0_1"/>
    <dbReference type="OMA" id="MGDPRVK"/>
    <dbReference type="OrthoDB" id="10498757at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="842"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="682"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="931"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="865"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="883"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1069" mass="121546" checksum="540B7351E0D7E361" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG27</accession>
    <name>N1PG27_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_177572</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG27"/>
    <dbReference type="STRING" id="675120.N1PG27"/>
    <dbReference type="HOGENOM" id="CLU_057738_3_0_1"/>
    <dbReference type="OMA" id="WICLASH"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME40525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28572" checksum="6D7D539AB99EA7A1" modified="2013-06-26" version="1">MDESSAKRPRYCTNCYNNVPPHRWPKEHQSTTCKHPNQVCKTCWKDWLLFQVDYHRSDRISCISCRATLSQEDVKVFAGMRVHGTYLDLAARNAVGGMEEFAWCLGKGGGSGQIHHGRSHGFECGVCKHRHCTICNLPWSIEHRRHCERCQAPEHEGKTCEEAATAHAVDERATIQAMKEIAEECPGCQRRIEKEDDGGCDWISCTKCQHEFCWICLASHKEIKSKGNEAHKEECSYHSVGKPLAFPFSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG55</accession>
    <name>N1PG55_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_36968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG55"/>
    <dbReference type="HOGENOM" id="CLU_1906689_0_0_1"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="133" mass="14385" checksum="6B1A7175310657D9" modified="2013-06-26" version="1">MAIINGSLQPETVTDFATCLKDDVECETADLPVFASARPRVIGKVGIFRALPSNEIGFVLDRTCWCRGPAKEALTTILAHLFSLKQEYEADVALREAVPALRVNLSSWSYEASGCILRSQQKLSRGIGPGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG61</accession>
    <name>N1PG61_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein HSM3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_90231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG61"/>
    <dbReference type="STRING" id="675120.N1PG61"/>
    <dbReference type="eggNOG" id="ENOG502S03U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014593_0_0_1"/>
    <dbReference type="OMA" id="PSAQWAH"/>
    <dbReference type="OrthoDB" id="4538483at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="67360" checksum="4F0AA88C8EA5A313" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGA7</accession>
    <name>N1PGA7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGA7"/>
    <dbReference type="STRING" id="675120.N1PGA7"/>
    <dbReference type="HOGENOM" id="CLU_723668_0_0_1"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="1">
        <location>
            <begin position="196"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="382" mass="43810" checksum="828E15DA5BE54CB5" modified="2013-06-26" version="1">MGVKKICTLVVPDRQYSPHSWDKIHWCVKTFQVEHLYWRAVDMLLVDEDRECSCDSDELRDKQQICFGTLRSLHLYCTGNKNTIQQWFSSRNGLSRLQKLSTLEIRIVEAPAMSGDKIQDLQDRLEKRLEDWRLSPRSDDNVVERVYTVERYQWNDEIGSRSRDAHDGTEFHIPELSRFLQQYRDNFGQHDQVPRTKVAVIDDGMMMVVNASRHSLQAQASSQVVKGKGFVYKDGSLSPWFSPGSDGHGTHMACLISRLDPHCDLHIAQVRGPNEPLYLSAVVMAIKWAIEQQVDIISMSLALRKTTPILESKLERAIQEAEQNHIVDEKYSQVMRFLPNLLVRSYRSRQQAASVNICRTVSEAGTTTVSQVVTSPWATSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGW5</accession>
    <name>N1PGW5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_82322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGW5"/>
    <dbReference type="STRING" id="675120.N1PGW5"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OMA" id="WISYYLP"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME40770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="301" mass="33043" checksum="8899C09B8F4B5E8C" modified="2013-06-26" version="1">MRQNSVLITGCTPGGIGYAVAKEFKARGLLVIATARSKAVVEELTADGLIAIQLDVTDTSSITACRQAVARLVDGKLDILMNNAGRGLSLPAIDSPLDQIRSVYETNVFAIMAMVNAFVDLLIPAQGLIINVSSITTLIPNVWGSVYASSKAAISSYSRTLRVELRPFGVRVQVIVAGAVKSNISDNTAKRTVLPADSLYRRALHLYERRKGFSQSKAAGSLPTNVFARKVVDKALASEMPLLWRNWFGRPDALYYGGMTRLLWWGSLLGDWVTDIGSWKAFRLFELQEIIERESRLTKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHV9</accession>
    <name>N1PHV9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_155806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHV9"/>
    <dbReference type="STRING" id="675120.N1PHV9"/>
    <dbReference type="eggNOG" id="KOG3232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080826_0_0_1"/>
    <dbReference type="OMA" id="QQITMVM"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904902">
        <property type="term" value="P:ESCRT III complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="198" mass="21811" checksum="056280CF902988D7" modified="2013-06-26" version="1">MSGLEKALFNLKFTAKQLNRQAAKAGKDEQTEKAKLKKAIQQNHTDIAKIYAQNAIRKKNENLNLLRLASRIDAVSSRVQTAVTMRQVTGSMANVVKGMDSAMRSMNLEQISAVMDRFETQFEDLDVATGYYENATSSATATATPQDDVDKLMGQVADEAGVELSQEMAGATPAQNIQQPAEEEREDKLGERLRALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI75</accession>
    <name>N1PI75_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_91067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PI75"/>
    <dbReference type="HOGENOM" id="CLU_1906693_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="133" mass="15127" checksum="98A1F873B9FBBD52" modified="2013-06-26" version="1">MHVKRQRLPISTSKTVTRRLMIQILRFSGGNTHLSRSLHCDLATNTSNPTDTSVFATRLPCIIEIPNHQCTPLQHNSRFLQSLVRPHQHPLRSLPLMQRHPLPHVSNDTLVLPINASQPLRHVCNGVKIEGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIQ9</accession>
    <name>N1PIQ9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_45820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIQ9"/>
    <dbReference type="STRING" id="675120.N1PIQ9"/>
    <dbReference type="eggNOG" id="ENOG502QPQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030747_0_1_1"/>
    <dbReference type="OMA" id="WSIYDAQ"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000015">
        <property type="entry name" value="Aureobasidin resistance protein Aur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="217"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME42257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="449" mass="50268" checksum="1F32D06F5351BC23" modified="2013-06-26" version="1">MRAQYFSLNGDGQTRFSFTMPRIPFSLPSLPIYVPHRIRRRFRSTRSKIRSRQAPTSSIASLETSFNPADTIRALRTHHWSYYDAQYLFLAVVGIFSLCMIETPGPLQKTLVATLLMTSLVIPITRQFFLPFLPIAGWLILFYACQFIPGEYRPGIWVRVLPALENILYGANLSNILSAHKNAVLDVLAWLPYGITHFGAPFVCTGLMFIFGPPSTAPTFARAFGYMNMTGVMIQILFPCSAPWYENMYGLAPANYSIPGSPAGLAAIDKLFGIDLYTSTFTASPLVFGAFPSLHSANATIEALFMSHTFPKLRPLFILYTLWMWYATMYLSHHYAIDLVGGSSIAAIAYFTAKGSFLPRLQAGKMFRWDYDYIEYGEEKDAYAYGMNDMDEYELALHGDSDEWTIGSSSSFSSSSREPSTGMRSPVSDHGSWEGDTLASSSDNEYQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIX4</accession>
    <name>N1PIX4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_26661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIX4"/>
    <dbReference type="HOGENOM" id="CLU_1310090_0_0_1"/>
    <dbReference type="OMA" id="HCQTITV"/>
    <dbReference type="OrthoDB" id="10513120at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109409" evidence="2">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="210" mass="20869" checksum="7B373C1EEC761A72" modified="2013-06-26" version="1">MHTTLSIPLTLASLALARTVVENSLTQTNPIEVTANRGPADDTPNNPSALSTSVDFSDLPTLTITDNVVPHCQTITVAGEPIFTIQTNTVLPTACTLTVYGGGSTTASGSTIIGGTQPTSGLNSDNGTSVVTDGPGTATGTAANTTSITADQGLPSSGHRTTTTGAQASTPAVSSRAFGSAARQSGLASNLEIRSAALVLFAAATAAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK51</accession>
    <name>N1PK51_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_27049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK51"/>
    <dbReference type="HOGENOM" id="CLU_2236523_0_0_1"/>
    <dbReference type="OrthoDB" id="10608673at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="105" mass="11346" checksum="4598CA0DEA6025F0" modified="2013-06-26" version="1">MTTADKGYDFPSEPLQTASGMNNTTPALHRRLSGDRAAAWATERKSLGALNALKVSDFDTRDNYNPFGDTLAGEDCAEWLEVHGDVPETAARYGLSKNVPALMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKF8</accession>
    <name>N1PKF8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_129299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKF8"/>
    <dbReference type="STRING" id="675120.N1PKF8"/>
    <dbReference type="eggNOG" id="KOG2538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015257_1_0_1"/>
    <dbReference type="OMA" id="YCLMEHY"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="7">
        <location>
            <begin position="477"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME43992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="584" mass="64243" checksum="B0521AF7F91A2136" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL88</accession>
    <name>N1PL88_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_53302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL88"/>
    <dbReference type="eggNOG" id="ENOG502RP1I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_359396_0_0_1"/>
    <dbReference type="OMA" id="MKMIPQP"/>
    <dbReference type="OrthoDB" id="3919589at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="784" mass="85984" checksum="F0D919EDAA6C267D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLZ5</accession>
    <name>N1PLZ5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_53595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLZ5"/>
    <dbReference type="STRING" id="675120.N1PLZ5"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_662265_0_0_1"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF5">
        <property type="entry name" value="BLL5978 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="415" mass="44153" checksum="4FF2E89023508AFF" modified="2013-06-26" version="1">MATQQKAPDQAFLSAGGFMRKAMINRSVGSDVPHVIPILDSLKPGEVVLEVGCGPGGITLSIAKRYPQLKVLGVDIDAESIKDAKAAGQGLSNLSYAVADVVNLVDSIENSSVTECIKTGCSLVYSHAAIMHTSNQVQAIKSMRAACKTGGTISLKEGDMGLFFAYPEIPGMQKLMEVFPRIGCTEGADALCGRKLVSHALAAGLSRDDAHPFELSMSAQITTATMHRAGFAAGFDKIFETNRKNPELMRSAGLNEGIVSLIREGTNSVKAYNTPNFYIDTSNFIFPADYTVAVVGAGKGIGEYIAKAYPQAKASQTLTTARTAMDLDSIKNDCQSINGNFRILALAAHATDPTSYVIIVKALGRESDGRLHALVYNAGGGVSQGLFENNVHEMNFESYSTITDLNYLGALYATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMD0</accession>
    <name>N1PMD0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_152496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMD0"/>
    <dbReference type="STRING" id="675120.N1PMD0"/>
    <dbReference type="eggNOG" id="KOG0715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050546_0_0_1"/>
    <dbReference type="OMA" id="ANPGQHP"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053025">
        <property type="entry name" value="Mito_ATP_Synthase-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="37"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME44556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="277" mass="30258" checksum="E19A267282ABE697" modified="2013-06-26" version="1" fragment="single">MIRSCVWRRTACLEQSRAKARPFHQTTGRRDDHGMPDHYATLDIASSASPKDIKKQFYKLSKANHPDLHPDDAHASKRFVKISEAWAVLGSPDKKQRYDRDFFRARQSSEPSNSGNTPQGSHSSSQTGPGGRPASGLSRRRTTFRGPPPSFYRSGGWGEHSAKREEHASKASHTSETSGESASGPQGPGMGPGGFAGGFDGEVPHFNNRAHTATHEELAERARVRRRRAVQYESAEMSGSGGSSVLFNFFMVTGLLGAVAAVSSMVYGGTERRRQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMU8</accession>
    <name>N1PMU8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_62725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMU8"/>
    <dbReference type="STRING" id="675120.N1PMU8"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_1"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052733">
        <property type="entry name" value="Chloroplast_QOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013:SF1">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="10"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME44243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="284" mass="29759" checksum="FDD9DC14130FD43A" modified="2013-06-26" version="1">MPDRPSRRFRPNKSPRLRSSTPTPIRTFNGHLIHVHAVSLQTHGPKGPQIAIVHRLALPNPCIPGFDVVGEIVALADGSSLEPGQIAFGLSASTLDGGAALVEYTAVPADVLVTMSKGMEMTDVASIPTGGSTAYQSVVSLDKHGDKVSTNGGFGGVGTHGIQFAKIVGAHVVASCSRRNVEVCWSLGADAGRPFDFVVDNVCNGFDLYCKMHTFSSSEAKYMVVGWGPSLAAIGFILMASLTVEGKLKAVIDSSSSIENTVNACRKLKSGRAVGKIVEEVAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN05</accession>
    <name>N1PN05_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_172441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN05"/>
    <dbReference type="STRING" id="675120.N1PN05"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_15_3_1"/>
    <dbReference type="OMA" id="RCIRTAW"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="88"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME44298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23956" checksum="BB90858FF29A95F3" modified="2013-06-26" version="1">MGIKLHFLQASRCIRTAWQLDELGLDYEVNFAPREKGVAPADFKKQAGGLGKFPTLEDNGQVIYESSNICEYLCDKYDKQHKLLPSPGDAHRYKVLQWVHASEGTFMLHGLAVLYAKWFQKGGDIEATVAGLSKNVHKDLDYLETTLGESKGKFLFGDEPSAADIMMHFSAAFILARELGTAGKSWPNINEWIKHCEERQAYKKAVQHTGHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNE5</accession>
    <name>N1PNE5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_70839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNE5"/>
    <dbReference type="eggNOG" id="ENOG502STER">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_502491_0_0_1"/>
    <dbReference type="OMA" id="IGIGWWQ"/>
    <dbReference type="OrthoDB" id="5350410at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="4">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME44922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="542" mass="59110" checksum="A1219C32D15F2FD6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNQ9</accession>
    <name>N1PNQ9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_24579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNQ9"/>
    <dbReference type="HOGENOM" id="CLU_1402399_0_0_1"/>
    <dbReference type="OMA" id="STSINYW"/>
    <dbReference type="OrthoDB" id="3637282at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="194" mass="22612" checksum="5EE3050768EBCA18" modified="2013-06-26" version="1">MCDYITFESLEAKYRDIAKEDAINNYWKPDTIDPDVAVGQLIALERKLFRHNLSPRRSQSLHKRRQREMVLYERCTTEELEKFCADRSITLCNSVMTSTEIIKKALEHADHCATFRFLLHVPAELREEIYHHYFNSLIIDAIFPTGLPIFRASRQLHLEVLPLFSRGSTFTISIPLMSKDGILDFSTLHARVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNY7</accession>
    <name>N1PNY7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ima1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_53675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNY7"/>
    <dbReference type="STRING" id="675120.N1PNY7"/>
    <dbReference type="eggNOG" id="KOG4623">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013127_1_1_1"/>
    <dbReference type="OMA" id="YPQVCES"/>
    <dbReference type="OrthoDB" id="5966927at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034992">
        <property type="term" value="C:microtubule organizing center attachment site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071765">
        <property type="term" value="P:nuclear inner membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042321">
        <property type="entry name" value="Ima1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018617">
        <property type="entry name" value="Ima1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538:SF1">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09779">
        <property type="entry name" value="Ima1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Ima1 N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="391"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME44638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="606" mass="68661" checksum="6CA28F30F6C8D790" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPI9</accession>
    <name>N1PPI9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_71118</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPI9"/>
    <dbReference type="STRING" id="675120.N1PPI9"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_2_2_1"/>
    <dbReference type="OMA" id="AVMITCN"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="122"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME45302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="284" mass="30219" checksum="428C5A81F6CD6B5C" modified="2013-06-26" version="1">MLGSILSNILLVLGCCFISSGIKRGESRFNETVASTMSSLMAVAATSLIIPATMYAALSRSTADSDGNILVLSRGTAIIMLILYVLYLVFQLKTHAHLFDAESQDAEGGENKEPEILGPVAATVALILVTILVAVCAEYLVDSIDAIVASSGISKTFIGLILLPIVGNAAEHVTAVVVAWKDKMDLAVGVAIGSSMQIALFVTPFLVILGWIIGQPMTLHFQGFETVVFFLSVLVVNYLIQDGKSNYLEGCMCLGTYIIIALAFWVYPEDAGDIGELVSGFFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPS1</accession>
    <name>N1PPS1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_71220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPS1"/>
    <dbReference type="STRING" id="675120.N1PPS1"/>
    <dbReference type="eggNOG" id="ENOG502SAV6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070614_1_1_1"/>
    <dbReference type="OMA" id="HVTARIR"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="8"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="322" mass="36265" checksum="F16EBED31F8F084C" modified="2013-06-26" version="1">MKHYLHPGVQVSLRVGGVDLAEYNIDDEEDEEVNTVTKYVEAVSGANFTVNFNAKVDCAPDPRDSCQMSVHLDGKYVTNIVFKMRDTTALARGTFEQLCEGHRSTAAAGGYNLEKFAFAALQTNDGPVKAEKIKELKKLGELSVRCTWARDAGTSHRLDHTPYKSAFTNGVSEKSLKGRAISQHATLAPPERRNGVFRLIELEYPYGNVPFAVFAFRYRTRKDLQIESVIPRSPSPTSLEERDPDDLSPEEMRELLRRMREREAYTVRVKREGEKCERRARSTTGIDRGDDDDDDFEITTGPAKRRHTSNDSGVEVVDLTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPY1</accession>
    <name>N1PPY1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPY1"/>
    <dbReference type="eggNOG" id="ENOG502SA1B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069867_6_0_1"/>
    <dbReference type="OMA" id="TRYTHWQ"/>
    <dbReference type="OrthoDB" id="509124at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="204" mass="21960" checksum="D619A1C52FE51BB7" modified="2013-06-26" version="1">MLLPPLSGISPLLRLTDAPGLGPHAVLDARCNNSIIGTPSFGLDNAIFTVCAEITIDAPVEAVYETWVDFESYHLWNSFVTDVHALPGSSISQVPPQIGTEMLFSNTFPPIPKFLPGPSVERLSYTEPNADGRGEAALVAWIGYESAEHPSVFTDIGEGRTGFVSWETFYGVHGTALVAGKEWLQGRHETQARDLKGYVEGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ64</accession>
    <name>N1PQ64_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_87880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ64"/>
    <dbReference type="STRING" id="675120.N1PQ64"/>
    <dbReference type="eggNOG" id="KOG2234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024645_2_0_1"/>
    <dbReference type="OMA" id="IEEDMMT"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097624">
        <property type="term" value="P:UDP-galactose transmembrane import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME45571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="454" mass="49322" checksum="FA18A5A2B7EF0DD1" modified="2013-06-26" version="1">MATESGRRQAALAGIPVRDLVLGALVVQNAALVLLMHYSRVMPLVNGDRYFASTAVFLSEVVKFSFFLSMALYEIATSPQTPDTSTVSELAEALSKAVFTGDSWKLAMPAVLFAATNSLQYVAASNLDAATFAITYQLKIVSAAMFGISLMGRVLNVRKWLSLGVLALGILVVQISYVSRQGRVLSIKDLREGVSFKSPRSIWDMEAEGNVAAGQLNKRSATYEGIDDDVAAANPKMNASIGLAAAVLGCILSGLACVYFERTLKAKGDTRVSIWVRNLQLSFYSIWPALFLGVFFMDGEHLSRTGFFTGYNFIVWAVIFLQAIGGILVALALNHSDSLTKSLATSVSTVITFLTSVVFLEFHTTLFYLLGMIATTGAAFLHNSNPEERRPRLPPINVTQYEKDGGQGYFDIEAVATAGRSPLRDPMREALVTSRPGTPVSERHFRPKSAKRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ79</accession>
    <name>N1PQ79_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ79"/>
    <dbReference type="HOGENOM" id="CLU_2542555_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="83" mass="9419" checksum="502BE556CB79E3F8" modified="2013-06-26" version="1">MPWYIYQLCSTRRICHWIQTCFGTRFGDTNVLTLASQRRPPYRPISSRSCIGESLRSGLYNFLQKFGPEALKSGVLGPSCTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQJ5</accession>
    <name>N1PQJ5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQJ5"/>
    <dbReference type="HOGENOM" id="CLU_1713206_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="153" mass="17927" checksum="6A30013F909735E8" modified="2013-06-26" version="1">MRPNTHWREQKEASARRSSHVRLDWASTRQHRPSRQLLAARMGKRDYKHFGHNVLPRRRPRSHLTRSTIDTHTGLNGEIGNLQHQERDLVGTLGRRTQCNSGRAHPRDTYSRRSESRRRHVPLSFQSLIVEREGPRIYVDVASGDEGEIRIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQL5</accession>
    <name>N1PQL5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_24646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQL5"/>
    <dbReference type="HOGENOM" id="CLU_1627003_0_0_1"/>
    <dbReference type="OrthoDB" id="3645509at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="163" mass="18434" checksum="6EEAAF6BAC55514C" modified="2013-06-26" version="1">MTNKPCHLLKLPPELRLAVYESVYCLETLHAKGAHLHDMGQPALLYTCTTRFTESRSAFDTQINRIANHAVQKMETSRYIVRIMYEHVRGSLYSGVVDFDVDELYSPDMADEARLHARDMVIGLVLKGRHKVRTFDEVCAPTLAARDEPSEVVLENVGTDAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQX6</accession>
    <name>N1PQX6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_23824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQX6"/>
    <dbReference type="STRING" id="675120.N1PQX6"/>
    <dbReference type="eggNOG" id="ENOG502S7DE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169147_1_0_1"/>
    <dbReference type="OMA" id="YKAHTRL"/>
    <dbReference type="OrthoDB" id="10670549at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME45851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="81" mass="9528" checksum="201DAC05A4C9443B" modified="2013-06-26" version="1">MRASFPRKAGFPSFPGLYRKNNVPVWQRMHQNHDGVRQWDKGPRAKYMLYPYYALLISTTAASQYMMIRMVLGHKTWFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR20</accession>
    <name>N1PR20_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR20"/>
    <dbReference type="eggNOG" id="ENOG502TEI5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2740860_0_0_1"/>
    <dbReference type="OMA" id="LMGDIKN"/>
    <dbReference type="OrthoDB" id="2872121at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="71" mass="7647" checksum="E4B4817F9BF9AE71" modified="2013-06-26" version="1">MSDLLDKAKDLVGKKEDKDAQAGDSVERGADDKINNEVNNFASQEGIPQQFDKGIDDVVDKKVNSDIPGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRH4</accession>
    <name>N1PRH4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_22110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRH4"/>
    <dbReference type="STRING" id="675120.N1PRH4"/>
    <dbReference type="eggNOG" id="ENOG502T24Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031896_0_0_1"/>
    <dbReference type="OMA" id="IMWAGMS"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="265"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="488" mass="55259" checksum="2A8259DA5F8EEDB9" modified="2013-06-26" version="1">MSFMSREKFLEEYVFEVDAEFERNGNAAEWAPSSNGGAQHWGQEISRLKLVDTDPGTGLRPESAAFALSDDGLLMAVATNKVIRIYSSWDQHLEAELVGHLENVTKVFFAPKNCYLEESYTLLSEAEHYSKEKHNPLILWHIDGGGRLITRTMPFAIDSLADKALGAIKMDLTTHHELPASSMAEVRKSLVNTLKIADTKNRSVTLTTLPGSFPGFGSKVFSSDKKLFLHLEHNNTTQSGMRPPDQLPQVVIRSLNGPETEMARLQGHEDAIMWACFSPTDPNVFATAAWDKTYQIWNLEHKTSSSIIGPTVGQNWSGDFSPDGKHVLLSGTNNVGVYSVATGDQVAKLERPKLEAWVRNLEWSPAGDAVALCNGIEILLWEPFREGEERRSSGMNVVKLTKPENRVLENFMRFHAAKWLDRRGRRLAVMAGDGTVMVWDRKENWKWRFQRPQGRAMKLWTHEIVYVEETEMLYVLDGDRKVRRWRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRH9</accession>
    <name>N1PRH9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRH9"/>
    <dbReference type="STRING" id="675120.N1PRH9"/>
    <dbReference type="HOGENOM" id="CLU_2158292_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="111" mass="12687" checksum="F27FB67EDBBBC5C3" modified="2013-06-26" version="1">MPPQQPPLQQQRNRQLSTSTARAQAEFTPINAGAPLQQHPDYRQQQQQQQQQANDQRQQQQSFSQVRGSRHSHSSHTQYHGSGSAGTGVGPRGINQHRYTDRPPRSQQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSF6</accession>
    <name>N1PSF6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_87682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSF6"/>
    <dbReference type="STRING" id="675120.N1PSF6"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_5_1"/>
    <dbReference type="OMA" id="PYFFLRL"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="125"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME45300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="527" mass="58980" checksum="5CE4D04AE7342CDC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSN9</accession>
    <name>N1PSN9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_22534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSN9"/>
    <dbReference type="HOGENOM" id="CLU_874433_0_0_1"/>
    <dbReference type="OMA" id="WAIAETT"/>
    <dbReference type="OrthoDB" id="10650406at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="318" mass="35060" checksum="27A647AA8F148FBD" modified="2013-06-26" version="1">MPARKTAPTTGQLRPGQEERKDVREALRAIVGETLYLRKDALMRASVYAELAHTLARLLREEDNEALDTIGYYVSAAWELLYHAQEAAPDEEEDAPIASAPEERDRSRHTGLAAPAKRGPRKPKKASSPAQDNDDARIAEVMPKKRGRSRKRPSPENKDRPGANDEQTVSTVPPKRKRRGRPGMNLLSPPEDDGAELDDAEDEKPTTSASTQNRGQIPAPKAPQPVTEGAKSTSTARVSGRNKRKANDADEKDAEMTAPPPVRRSKRARNGLVVDGNTAMGGSQVRAPVTWYRARNGQWWEELDATGRPDWAVDEKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTB0</accession>
    <name>N1PTB0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_71369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTB0"/>
    <dbReference type="STRING" id="675120.N1PTB0"/>
    <dbReference type="eggNOG" id="KOG4031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069856_0_0_1"/>
    <dbReference type="OMA" id="FYENYNT"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME45644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="252" mass="27435" checksum="8D44A5DE495052C1" modified="2013-06-26" version="1">MADRFPSLDEFDAGQTEAQGSSSLHNLESEEPSDFLARERAALGEDAEQFTTDADRTAQVADDDDDLLGGGSAPMHATNGDSANDMTGDFESSFPAVDTRNEAVAPGGTITGSTMPYRAPQSSEYQDYEDEPEVLKEWRERRDLQIQHRDEVSASKKAETVKAAQEAIDEFYENYNNKKDKNVAQTRKEAEEFLKSREDTTAGGTSWERIAKLVDLTGKGQAGGAAGSGKAKMRELLVSLRKDERAPGATGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTJ4</accession>
    <name>N1PTJ4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_23671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTJ4"/>
    <dbReference type="eggNOG" id="ENOG502TAM0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150137_0_0_1"/>
    <dbReference type="OMA" id="VEENGWH"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="118" mass="13435" checksum="9B173D276EF4F03C" modified="2013-06-26" version="1">MATTNFDTSEQIRDHKLVTSIINRHGTEDAVFDDRHLALLQRFCETPTIDTRDQIVEENGWHDSAGDRPGEKAANEGNLSGFVIARHGTNDPAFDDRDIEMLKRWFEEGKPKGQKVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTL8</accession>
    <name>N1PTL8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_88014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTL8"/>
    <dbReference type="STRING" id="675120.N1PTL8"/>
    <dbReference type="eggNOG" id="ENOG502SH99">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090057_1_0_1"/>
    <dbReference type="OMA" id="WKHDGVR"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02210">
        <property type="entry name" value="cupin_BLR2406-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052535">
        <property type="entry name" value="Bacilysin_H2HPP_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40112">
        <property type="entry name" value="H2HPP ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40112:SF1">
        <property type="entry name" value="H2HPP ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="178" mass="19615" checksum="FFD03029187D1E01" modified="2013-06-26" version="1">MASNPSSRDHSHDHAHEHSHPSPNDDWKNTGVRVIPSDSLDSNTPQTPGMDRAAAINFARVGAQKLWAGTVNIHANAKTGAHHHGHLESVIYVLKGKARMRWGEKLEFTAEAGPGDFIYVPPYVPHQEINASEDEKLECVLMRSDSEAVAVNLPDLEPVEMVNAETVRWIDPTHANLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTS0</accession>
    <name>N1PTS0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_128526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <title>The Genomes of the Fungal Plant Pathogens Cladosporium fulvum and Dothistroma septosporum Reveal Adaptation to Different Hosts and Lifestyles but also Signatures of Common Ancestry.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Okmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H.A."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">NZE10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTS0"/>
    <dbReference type="STRING" id="675120.N1PTS0"/>
    <dbReference type="eggNOG" id="ENOG502SI51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_657247_0_0_1"/>
    <dbReference type="OrthoDB" id="5423926at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="418" mass="45143" checksum="F8FBF2239A3E5E43" modified="2013-06-26" version="1">MAKSMRGGPVASPAPAREARPVSPEPVRGKGRDSFSIRSLSPTGSLFGRKRRAEEVKQSIRGINADSGARMSMRHQPAQKPIRPRSTQKPKSAASKFKSRFADSDDESDDDKASRDFFKSRFATESDDEDDDVFIPADLRPVRGIPRRQGQTDGDSTDLEDEEDNSRTSSRGREKMASPMVPASADVDAAMEIARKKLGITNGPTESTPSEQGGALQQGSLRGTATASQVEPKSKLEEVDLTPRKRGWSLLRRNRNSASSVTQVTSRPSSDVPPVPPVLPSPTLAGPMIATFDTPEPQTPTPRPRSPTISLAGKLVRRSSAQQAPRFRRGDSTYSNATAPPAMGESTVFGDWPLPPVPSVPEKYNDRPFTSDGPQVRFDESSDPGVNTAAEGRGGVFSARTGKKKKFGMLRKAFGLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTW4</accession>
    <name>N1PTW4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_171519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTW4"/>
    <dbReference type="STRING" id="675120.N1PTW4"/>
    <dbReference type="eggNOG" id="ENOG502SK2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091428_0_1_1"/>
    <dbReference type="OMA" id="TQDWISI"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="2">
        <location>
            <begin position="31"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="206" mass="23012" checksum="F2D59313BBF1B4B4" modified="2013-06-26" version="1">MPEKVNDLDATRDPSVAKQYDNESSTETKFKDFYKIADDRKICMMGTYRNGVGPVSRSMAVAKRTGPDFLFLANTNSKKFEDLQNKETCLIFHDSNENWISVTGEAVTTSNDDPRIKEVYSKVVSAWFGDLGDGVHTGGPEDPRMKLIEIRSKYISYWKKTTGPLTTAKEIGGAALTGRVANTGDLREMHQEEISQQRKKDSALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW39</accession>
    <name>N1PW39_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_43091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW39"/>
    <dbReference type="STRING" id="675120.N1PW39"/>
    <dbReference type="eggNOG" id="ENOG502QS1V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056435_7_0_1"/>
    <dbReference type="OMA" id="LREPSEH"/>
    <dbReference type="OrthoDB" id="3365399at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF6">
        <property type="entry name" value="CYSTEINE SULFINATE DESULFINASE_CYSTEINE DESULFURASE AND RELATED ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME46604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="322" mass="35316" checksum="2A9235D0F685F85F" modified="2013-06-26" version="1">MRGILSTTCRTTSRIRLAVTSPASKIYDSAFHGVETQTIMAGTFPADAREKLRQQFLDQPEENLTNRWDDLWQQKLTPWDKNGPSLALKDAITDRPDVFGTAIKDDSSKTRKRALVPGCGSGYDVFLLASLGYDTYGLDAAPTAVNAAKQIQAEIAADERYAVHDSEIGRGESKVILQDFFKDDFQAHTGGAGFDVIFDYTFLCALPPDLRPRWAQRMSQLLGPLGKLICLEWPLGKDPKLGGPPFGVTPELFGQLLSRPGKEVKYDDAGVVVVEDQSGEGSDHGLVTIDRFLPSRTHESTKGNDHVSIWQHQQGPGAKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWA0</accession>
    <name>N1PWA0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWA0"/>
    <dbReference type="HOGENOM" id="CLU_2291621_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="101" mass="11549" checksum="C3EFF2D6505B406D" modified="2013-06-26" version="1">MLERLRDLRTLRKCFEEHRSQHPVDHGFESPLNILQEGRNQGPTSLLDPIVMEYDSELICEAVETVNKRYCKCNTASTQFLLRRGSAAGINSTRNDTTLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWJ0</accession>
    <name>N1PWJ0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_69329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWJ0"/>
    <dbReference type="STRING" id="675120.N1PWJ0"/>
    <dbReference type="eggNOG" id="KOG2049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004133_0_0_1"/>
    <dbReference type="OMA" id="HYKGELY"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="581"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="603"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="639"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="675"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="712"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="748"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="784"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="820"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="856"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="563"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="999"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME47358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1038" mass="113900" checksum="DC8CC9BAA92FD09B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWU6</accession>
    <name>N1PWU6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_69816</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWU6"/>
    <dbReference type="STRING" id="675120.N1PWU6"/>
    <dbReference type="eggNOG" id="KOG1467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_3_0_1"/>
    <dbReference type="OMA" id="MRDYVIC"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME48006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="495" mass="53400" checksum="A73641C91C75960A" modified="2013-06-26" version="1">MTEQQKPEQPAAEEQKLSPAELKKRAKAEKQARRAAQKEQTGAPAGGPPAEEAATNGEPKLSKQGGGGGGGGPAQQKPKGEKQQQQQPKGAQKQGDQGKNQGGAEQASLPVRNRRGSQSAPKESVTRQENKQVELFSHLYNQPRRQTLEGISKDVHPAVLALGFQMSSYEICGSSARCVAMLLAFKEAIQEYTTPAGTSLARHLTSHYLSPQIDFLKSCRPISESMGNAIRWLKKLIVEVDPDVPEHEAKDQLWNDIDRFIMERITATDQAIASSASGLIKDGSVVLTYAKSSIVEKTILQAHAVGTKFRVVVVDSRPLFEGKNLATSLMNAGLQVEYYAFAGLARAVSDATLVLLGAHSMLSNGRLQARIGAASLAAAAHRVDIPVIVCCGSVKFSGKVALDSIVINEVAPAEELLLPAKTQLSIPTAKDAKNDEGEETKLKSLHDWKDIHNLQILNLMYDITPAEYIRMVICEYGSVPPSSVPVVHRLANEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXY8</accession>
    <name>N1PXY8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_18927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXY8"/>
    <dbReference type="HOGENOM" id="CLU_1156360_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="240" mass="27075" checksum="D8FECD102A34FBE4" modified="2013-06-26" version="1">MSNRVDGLSLGVGGRCWSLGQEEPMEQLHDGHRTELSTSTESEAHTGGQMVSKGSESSTCALQKWHESRRHRPPTRAIYRPSQPASLLSTYNGKHHQYTTSAPEQPSSEDNMASNCVTLMTLPTELRLEIYDRTMALFNFNHPRYSVPEHPLLQTSKQVRDEAMASYNKRLTIIVKSHTMEFLIATLELLAAIVVSGPGSAEVLTAKEESAKMLHRARLNDWLMKKKRRQLKEVGYELQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZ48</accession>
    <name>N1PZ48_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_67754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZ48"/>
    <dbReference type="STRING" id="675120.N1PZ48"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044629_0_0_1"/>
    <dbReference type="OMA" id="AWYRSRC"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40981" checksum="ED2195D2E64D45B4" modified="2013-06-26" version="1">MLSTFWSPSELQLLVGTTLAPAVTSKLKSLQREYNQLCASAARTRWYRFVQEHIALDDWMQVDAMFRSRALDFYGSCMIPGMDLASHAAGDKTNAFYDRADDKYYLWLSEDKNLSAGQEVNISYGDEKGACEMLFSYGFLDDEMATAGTVFLSLSISNDDVAKTAKMKIAGCAPGFKIIDIPVDKGSESAVEAGEAHSTPANDQESSFSGVGWKGSFVWLCCVNHDDGLRFELVNTVDGHEELRATFNGQELHGADELPCLLAQTYMWPVYRLRAVVVLQQRVFDQLQVLYCTQEEIETVSHGDASDIRETPYQQAMQLRRLEFGLLEKAYEEFERQKLRLAESAVVQQYLTSITADQSAQGEDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZ59</accession>
    <name>N1PZ59_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_19328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZ59"/>
    <dbReference type="HOGENOM" id="CLU_792325_0_0_1"/>
    <dbReference type="OrthoDB" id="10564934at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="350" mass="40049" checksum="1A0ECEB2AEEA1AE5" modified="2013-06-26" version="1">MAAYLTCSQLDLRSIDMDVRLADLIERLADYVEMLAEENNTCQRSPRATGRIQRLVRAQGLTLAIPVHDEPTPVSYPMSEIEYLDQRIQRLASEFESLDTQIHSLNDGHRDRTRQRATSLPAEMVQAPTNNLSRSDSMPQIHASHILNNTFAETLQAQIRQMSAEASHAVHVQDVMMEVINIQQTTLANPVLLFNSANDSVSRAFSSNERDILNHHGIIAHDFAIDQDNTLLYPPRTLDARGLVRPRVSSDSLGLQRNARRGNPWEVQYDYRHEIDNSRTLVVFDRSCLEHFRRLTQIEDIGQTLQSVIRVYVENCMHLVDMDQLVAYELNQARDRFILSDETAEELWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZJ5</accession>
    <name>N1PZJ5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_18965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZJ5"/>
    <dbReference type="HOGENOM" id="CLU_1004813_0_0_1"/>
    <dbReference type="OMA" id="HALNRIC"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="277" mass="31162" checksum="F1A1F6EDB23A0080" modified="2013-06-26" version="1">MSSASSTQPATQAPQDFASLLRSLSVPDGKPLATPAQDPLRPSTFAAPSSLLMPDKLPTYTESESTRGTKRKADLPATKPIPDPSNPFYDPRLDLKHAAGLIYKTLKAAHTSTDRWAETMIESHFLLLADKSKHQPDHALNRISKDITHIADLLRLGRKGWTLTDLPYNLFQDVEQLIPDIVIDLNKLSEYHGCGWLLQRAVLPTVEVEKRLRGIHKERQRIETEYKAKQAKFWNEDARKLIKKEDPTVAMERVFGFKSERNDDEERVGKGEGAKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZU1</accession>
    <name>N1PZU1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_95197</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZU1"/>
    <dbReference type="STRING" id="675120.N1PZU1"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012773_0_0_1"/>
    <dbReference type="OMA" id="NCIHVFL"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF46">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME47734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="703" mass="80097" checksum="D4A154F7112A6842" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q093</accession>
    <name>N1Q093_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_40413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q093"/>
    <dbReference type="STRING" id="675120.N1Q093"/>
    <dbReference type="eggNOG" id="KOG2552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030193_0_0_1"/>
    <dbReference type="OMA" id="ALWHLWI"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109751" evidence="10">
        <location>
            <begin position="23"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME49171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="446" mass="49312" checksum="1494C7837003111C" modified="2013-06-26" version="1">MLLFSTAAVLRLLLALTFPALPDLLTGRVEISSPVNSFKRLQEGLFLYERGLDPYDGGIFHQAPLLLPLFSLMPSPSTTLGRIISILLYTGLDIISADCIFDIAKSGANAVSSVYLSPRADRSWKPTSVVAVYLFNPFTVLACLGRPTSSFTTVFTLLSLKHACSAEAVTSAFALAIASYLSLHPALLLPPIGLLCYDRKSHMQIGNTTHKTASETQKHTTQGVDVTQDQRSLPARLPFATMVIAAFAVSLALLLGLSRLLLPSWYFIVSVYMTPLTLPDLTPNPGLWWYFFTEMFDAFREFFLGVFWLHMLSYSVPLCLRLRKQPLAAVVVMMGIIAVFQPYANVGDVGAWLGSLCLLGHVFELCSTHRYTFPALAALLYASLLGPAFHHLWVYAGSGNANFFYAITLVWSLALSILLTDIIYAVLRDEWEVERPETKGKEIRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0A7</accession>
    <name>N1Q0A7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_32275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0A7"/>
    <dbReference type="eggNOG" id="ENOG502R945">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_377229_0_0_1"/>
    <dbReference type="OrthoDB" id="5272396at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="544"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="735" mass="83492" checksum="F861E01979EA6B45" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0C0</accession>
    <name>N1Q0C0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Multicopper oxidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_68090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0C0"/>
    <dbReference type="STRING" id="675120.N1Q0C0"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_7_1_1"/>
    <dbReference type="OMA" id="GFWLYHC"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13857">
        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13910">
        <property type="entry name" value="CuRO_3_MCO_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="114"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="241"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="495"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME49211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="74983" checksum="E7CD063D45EADF30" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0M9</accession>
    <name>N1Q0M9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_40122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0M9"/>
    <dbReference type="eggNOG" id="ENOG502RH0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1796422_0_0_1"/>
    <dbReference type="OrthoDB" id="2580323at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616:SF1">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="144" mass="15829" checksum="C7F317F321A44A86" modified="2013-06-26" version="1">MIESVHLNAVGDTYRVGSVDYDGLYPAYSNAAIMHAVVPSLGGRRTGDANLAAERETWSRAFVELSIVTACFLNSTNPRQHENPHSMALWIWTLAVLNHAPLYKKPWAVAHVNDCQIDPLITILADYHEQSVDGRISCNLSPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1E1</accession>
    <name>N1Q1E1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dihydroxyacetone kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_143547</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1E1"/>
    <dbReference type="STRING" id="675120.N1Q1E1"/>
    <dbReference type="eggNOG" id="KOG2426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017054_6_0_1"/>
    <dbReference type="OMA" id="TLGNMSG"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF1">
        <property type="entry name" value="YALI0F01606P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="9"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="384"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="54"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME49502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="63423" checksum="F34DDE0DA45DA035" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q283</accession>
    <name>N1Q283_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_118358</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q283"/>
    <dbReference type="STRING" id="675120.N1Q283"/>
    <dbReference type="eggNOG" id="KOG4620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154777_1_1_1"/>
    <dbReference type="OMA" id="VEMYSSP"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="5">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="82" mass="9550" checksum="0C6221E90307E450" modified="2013-06-26" version="1">MARGTRLSGLQRDVLSLYRKCLRAARTKPTENRPNFYAFARHEFEKNIAMDKKDFSTIEFLLRKGTRQLEIYEAPNITNIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2P6</accession>
    <name>N1Q2P6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_50123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2P6"/>
    <dbReference type="HOGENOM" id="CLU_512900_0_0_1"/>
    <dbReference type="OrthoDB" id="10684831at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="531" mass="57714" checksum="4195BEFCF814E31E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2S4</accession>
    <name>N1Q2S4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_119515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2S4"/>
    <dbReference type="STRING" id="675120.N1Q2S4"/>
    <dbReference type="eggNOG" id="ENOG502QRW4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017810_1_0_1"/>
    <dbReference type="OMA" id="GETSPKW"/>
    <dbReference type="OrthoDB" id="3032304at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576:SF3">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="314"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME48955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="513" mass="57688" checksum="AF95913613E153EB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2Y2</accession>
    <name>N1Q2Y2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_41197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2Y2"/>
    <dbReference type="STRING" id="675120.N1Q2Y2"/>
    <dbReference type="eggNOG" id="KOG0009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_5_1_1"/>
    <dbReference type="OMA" id="YNTQNVP"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME50042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="62" mass="6905" checksum="3BB427B763679C0E" modified="2013-06-26" version="1">MGKVHGSLARAGKVKSQTPKVEPQEKKKTPKGRAKKRITYTRRFVNVTLTGGKRKMNPNPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q368</accession>
    <name>N1Q368_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_68850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q368"/>
    <dbReference type="STRING" id="675120.N1Q368"/>
    <dbReference type="eggNOG" id="KOG1182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_1_2_1"/>
    <dbReference type="OMA" id="GMFRGVN"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="10">
        <location>
            <begin position="105"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME50117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="460" mass="51597" checksum="39DA1172602EFCED" modified="2013-06-26" version="1">MASKRIITALGRNALAQGTLRSKTRPGKCSNCQQRWNSVSQKQGSDRVQFPGAVNSRFSTTLRFERATEEDAMPTYRILDQEGQVVDKEAAAPDISDEEALKLYKDMVTISIMDIIMFDAQRQGRVSFYMVSAGEEGIAVGSASSLNHKDPVFAQYREHGVFQYRGFTLDDFMNQLFATKHDTGLARNMPVHYGSRKLNVHAISSPLATQIPHASGAAYAMKMQNQQNPTEEPRVVACYFGEGAASEGDFHAALNIAATRACPVLFICRNNGYAISTPTLEQYRGDGIASRGVGYGIDTIRVDGNDILAVREVTRRARELALQDGGRPVLIEAMSYRVSHHSTSDDSFAYRAKVDVEDWKRRDNPITRLRKWMEGKGIWNEDKEKELRADTRKAILNAYRKAEKEKHPPLSAMMTDVYAEPTDEQREQMAQLRKIVEKYPNEYDVSSFDGGVDGLDLDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3F8</accession>
    <name>N1Q3F8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_68931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3F8"/>
    <dbReference type="STRING" id="675120.N1Q3F8"/>
    <dbReference type="eggNOG" id="KOG1347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_1_2_1"/>
    <dbReference type="OMA" id="EFWILLK"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME50217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="521" mass="56485" checksum="3749983A2CB2C116" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3G8</accession>
    <name>N1Q3G8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_67897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3G8"/>
    <dbReference type="HOGENOM" id="CLU_1992577_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME49004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="125" mass="13756" checksum="7AE482B477C8A12D" modified="2013-06-26" version="1" fragment="single">MYTTTNLSNGIALDSESLQPGCRQAATRSSTPLVLSSGEAKMQLICCIWKFGVSRTSWSRSLAVMMLPLQLNIALHRKRSRVRAAPGPVMSESEHPVHLLLLCRTTLKSSNLAQHYVRYGGLGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3R1</accession>
    <name>N1Q3R1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">homoisocitrate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_67956</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:11900"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.87" evidence="12"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3R1"/>
    <dbReference type="STRING" id="675120.N1Q3R1"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="OMA" id="DSFVMGE"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000012">
        <property type="entry name" value="Homoisocitrate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="7"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME49079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="361" mass="38510" checksum="08A49D5EA8399D5E" modified="2013-06-26" version="1">MATKTLRIGLIAGDGIGREVIPAGRRLLEALPSSLGLKFSFVDLDAGFETFQKTGVALPDKTVETLKKECDGALFGAVSSPTTPTKGYSSPIVALRKKLDLYANVRPVKSVVPTAAFPDPIDLVIVRENTQDLYVKEEKTYDGPNGNIIAEAIKRIDKHASSRIATMAGEIALRRQRVRKSSGESNRKSMVTITHKSNVMSQTDGLFRQSARTALGEAKFKNAGVVIDEQIVDSMAYKLVREPGTYDVVVAPNLYGDILSDLAAALVGSLGLVPSANVGDGFAIGEPCHGSAPDIQGKGIANPIATLRSVALMLEFMNQEQAAARIYQAVDGNLADGKLLSPDMGGTAKTEEVLNDVIKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3U1</accession>
    <name>N1Q3U1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DOTSEDRAFT_68209</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3U1"/>
    <dbReference type="STRING" id="675120.N1Q3U1"/>
    <dbReference type="eggNOG" id="KOG2292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009279_1_0_1"/>
    <dbReference type="OMA" id="TWYAIGT"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="22">
        <location>
            <begin position="26"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="23">
        <location>
            <begin position="557"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="739"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="745"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EME49350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="762" mass="85250" checksum="E3FCA35FB9720A05" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3Z9</accession>
    <name>N1Q3Z9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_68063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3Z9"/>
    <dbReference type="STRING" id="675120.N1Q3Z9"/>
    <dbReference type="eggNOG" id="ENOG502S6QC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059426_0_0_1"/>
    <dbReference type="OMA" id="VYNHFRT"/>
    <dbReference type="OrthoDB" id="5401558at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME49194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="377" mass="41415" checksum="DBFE2432E9622C45" modified="2013-06-26" version="1">MYPTSQSNQQPQQWTPNTQPANNQYQPRPNPNQLTPISQAVQQQGAPPAMQTLQPNHPDQYRALPPPQQMYGPPYQQAPQMAYPPTQPAPRQRTAIACRYCRRRKIRCSGFDQSEDGRCTNCQRFSQECVFTPVSAQTQAFVPAHTVWRGQNPPPNTQLYGAYGQPLPQHGNRDQYQQQQQQQQPGQYPPPPQGYQQQQPMYSQQGGPQAQTAEAGRKRPNDEPHTPTLAPPNPGEQSQMPQHRGADGQPYGYPDQSGLTPAGASPNSSSTSYYPAQHPPLPYYAQTQPQVRGVSPQSAYSYDVSRASSSPHALGQPGISTSFQHGVAIDDGRAPPASAANAQHHGGKVNDLAGKPKMEERTSTDSSMLQALNRGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q403</accession>
    <name>N1Q403_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_30670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q403"/>
    <dbReference type="HOGENOM" id="CLU_752319_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME49430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="368" mass="40308" checksum="A2D4434E574FB6A2" modified="2013-06-26" version="1">MYIHVLHEIALFALFHDASSPTFVLDSSLYDDENYNDAHIQAACFVPALGRSKAVHCLRAGSPSPTIVRSNMVIITTFDVAAHLPLGVLNLLSEIRASRKTPHWQDHKLHSSLPRLTLTFSWLTPASPRSLEYGRYAFAQYTTTIAAAGSPSSPQPACSRKMPFPWMAASQPSNATDIDTFASLPSLGGKSSHASPLRQSIEESRMAALTRPGVVYHAGMRYSEALPDTPTSITSATRRSRPATRAYAIVAVLVRARGVRQEMPQAVLAVHDAWPAMGYGFSQQGPMVARLDDAAAVDPNGICVQMRLEADLAGAAQEALVKLGRRFSRLFTQESRAPSEGWVHEETEIGKDLVCRREGRDEGRQTQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4Y9</accession>
    <name>N1Q4Y9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_68760</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4Y9"/>
    <dbReference type="STRING" id="675120.N1Q4Y9"/>
    <dbReference type="eggNOG" id="KOG3111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_0_0_1"/>
    <dbReference type="OMA" id="CHLMIED"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000130">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="174"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME50010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="249" mass="27131" checksum="75B1053360FC6848" modified="2013-06-26" version="1">MAPAAIIAPSILSADFGALGKACSSTIEQGADWLHVDIMDGHFVPNMTFGPPVVTMIRSHVDRPKAAFGKGTFDCHMMIAEPKKWVTEFKKAGCDLYCFHYEAAVASTSAESPEEHSEGKTSPKEMIKYIHEQGMRAGIAIKPKTEVDVLYEILDNPNKEEVPDMALVMTVEPGFGGQKFMHDMMPKVEALRKRYPNLNIEVDGGLSEKTIDTAADAGANVIVAGSAVFGARDPSHVIEALRQAVEQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5F5</accession>
    <name>N1Q5F5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_68957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5F5"/>
    <dbReference type="STRING" id="675120.N1Q5F5"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_1"/>
    <dbReference type="OMA" id="IHSKTRM"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME50254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="424" mass="47168" checksum="F55832E7C28B7C15" modified="2013-06-26" version="1">MTFASRDGLDIIILGGGIAGLTTALALTKFAPKGQVPRIRIFEIRSEPGVIGGAVNLTPNALRMLDYLGAFQIIRERRYGRDIDYLEVFDAYSGKIAESDFRGPEGKGIGNPPYKALRITRGDALKAVLSALEQCENITMTCGRRTVKIDETEENVTIHFEDGDSATGDLLMGCDGIHSVTRLKHVEPERTATYTGVANAFGFAPVSEDFQTHFECTAINFAQRGMLLTSYHSPSNESVYVGGLMSVEDVGSRDGWKSVGADAEKTRQKLLDRFGDAKIPCLKPLIEAAQDFFLWPVYTLTKEGKWSTDRVMLLGDAAHAMPPQGESTGIVFEDTVLFSRCLTRWIEKGKPNTMKEAFTAYENLRRSRIEDAFEESKNVVKTVSDAGWLGHKIKTFIVPWYLWFSKTNREKHFLEDVTTTDIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5G7</accession>
    <name>N1Q5G7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5G7"/>
    <dbReference type="STRING" id="675120.N1Q5G7"/>
    <dbReference type="eggNOG" id="KOG2624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024238_3_0_1"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109911" description="AB hydrolase-1 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME50314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="49968" checksum="F34A2613AA52BB41" modified="2013-06-26" version="1" fragment="single">MWAWNIRQMGVMDLPALISRVLAETGFPKLALIAHSQGTTQTFVALAKEQRPDIGEKISVFCALAPAAYAGPLIGKIYFKVMQVVSPAMFRMIFGIHSFIPLMLMAHKILPPVPYSWMGYHVFSFLFSWSDSRWDRGLRNRMFQWAPTYVSSESMRWWLGRECFANQKCILATREEGQLEDKEDEEDDAVIRQYYAEREKRDSGITPRRRLTRNLTSFRCQTLTHQHHDTKRGEFAWYDDRFPPLALWVCGADDLVDGRRLLRRFDRGREPHVRVVHKKIIEGYEHLDVIWAMDAIEKVGKEVREVIWRTAEPEMQKRCRVPVGCDRPMEQEPDSNDVPMTRSGGRSRMASISGRQPVERTGDGGTNVEESKDPEKEQEKLDRRNDEIDGARNDLDERRESESLFEDLVEKANPLSPLELPGDQRQLGVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2WHJ7</accession>
    <name>M2WHJ7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_39614</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WHJ7"/>
    <dbReference type="STRING" id="675120.M2WHJ7"/>
    <dbReference type="HOGENOM" id="CLU_983607_0_0_1"/>
    <dbReference type="OMA" id="KCQKGEW"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="236"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME38072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="283" mass="30950" checksum="C5F05269BF0336AF" modified="2013-05-01" version="1">MRAFLDLISDHNNSINIGHHIASASKHVLREDNITSDLTTSNKVPVLIISANGNRQRQQRSVRHHSPRRLRRHRQVGSGSIPCLQVPRAPLRANGVASELNAASKSNEHTFINAFFLDYDPYGNIFSTMLRAPYVGDQVILVRCHGLLLDAFFVSAMHDHITALTCDGKECGSKSACTCPKDGKRNKEAVKSACTKKVFSALLERTKATMALIPGAEAVINPLAEIVSKEGALSFCGGCGMAEKENGSGLIRCSKCRIAFYCGKKCQKGEWEGHKKECKNTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2WKH1</accession>
    <name>M2WKH1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WKH1"/>
    <dbReference type="eggNOG" id="ENOG502RWBW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_660609_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="416" mass="45816" checksum="D660C689571FF9C6" modified="2013-05-01" version="1">MEIFKERVPGRPGVKDRVKPAVISTPNSWNTVVASNPRPAHDAPQARQPPAGIPGISVKSSTAPAGVPGTSVKLTTAPASTEVVQVVNKRVLSYAPSATKAIGPIQRSDGGTAQQQYIEFKGTEAELTGSAYAIDLWNFLDSMWVRGKEKTLREMLDEYDPKCHASWVKWWMEQVGNNALCFRCAYLKLPCAHTIPCGPCIENKQAKFCQYARCTKKNRGTPVDCDEAKCKAFHQIHRDMIADWVTKKGQPGEDLIARLFSVNETPSRQWVAKHGTITSNAITKLWLKDPAAPCHLDLTALPPVGSGLPYSTDNPHSFDVQYQSFFWCGRPLWVWATEGQLDVALSYAKSRSDEESKKTGQQVVLPNNPFVWLSEDNGEGDAGEEEEEKEEEEDVENAKDGEAPSKDGVAKGEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2WKI2</accession>
    <name>M2WKI2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WKI2"/>
    <dbReference type="STRING" id="675120.M2WKI2"/>
    <dbReference type="eggNOG" id="ENOG502SVU3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_303833_0_0_1"/>
    <dbReference type="OMA" id="IAQCFIA"/>
    <dbReference type="OrthoDB" id="3648067at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="902"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="979" mass="109824" checksum="ED01BD4387F0A3D9" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2WM60</accession>
    <name>M2WM60_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WM60"/>
    <dbReference type="HOGENOM" id="CLU_2589732_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="80" mass="8645" checksum="966FA703492D5830" modified="2013-05-01" version="1">MRYSNLTWVKHSRCALLAENGARHGRTRLEADDACRCAQNSDTKVSTVVCSICWTGTVVASVVASALRETAGSLAKVMRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2XZN6</accession>
    <name>M2XZN6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_57673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XZN6"/>
    <dbReference type="eggNOG" id="ENOG502R8ZW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1061837_0_0_1"/>
    <dbReference type="OMA" id="ESKAGWW"/>
    <dbReference type="OrthoDB" id="5240110at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="262" mass="28660" checksum="0F11A352298EE5AB" modified="2013-05-01" version="1">MSSSLRPLIPTITTSRSVSITQTRKASILFALGALSNSRETQHFNKLSRLDRVEHSPNLKLIKTSEIDPYPLPTPPLSTASLVRDGARTSSSVAVWDRKALQAGRAILSDNARRLSRMARTVERTKRREMKAKHTRQAELAAWAQERQKMRAEQRSAGVLILASVATATGLAMWRFWPQETARDSGEMGRRIAERARASIPLPAARSVGDVAGGTSLVEAVGVGALPVTGVSTPIVPEVTTITAEPTKSWGWSLKNTFWKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2XZT2</accession>
    <name>M2XZT2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_141173</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XZT2"/>
    <dbReference type="eggNOG" id="ENOG502S6CG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029871_3_2_1"/>
    <dbReference type="OMA" id="WYKRNPS"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF1">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME38183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="370" mass="39568" checksum="085BE920D9BDE5ED" modified="2013-05-01" version="1">MPSTPPPFNATLQYVSNQGQYAFKAPGTGDARGECPGLNAMANHGYLPHNGVATIQQFIDATGTVFGMGQDLAGFLAVFGALVDGDGLGWSIGGLPHTGILGSHNDYETDSSPIKSDLNQYGSNTKFVMSQFYNLYNRQPDAASANYNLEVLRAFRGDRLQESIAKNPYYAYLPFTGIAVSQAAFTFIYRFMSNKSAEYPEGLLNKAVLKSFMSVTGPENNLTHTPGYEAIPDNWYKRNPSDDYTIPYFISDIGYFGQTQPGIYQIGCNKGKVNTYSPFDPSQLTNGAYTAQQVAANPVCFAAEFAIAEIPLLSGVSTNSAALITQLKSYTSALNCASIGSVNQSALTSCPGFSFYGGPTGPVAPGAIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y0G5</accession>
    <name>M2Y0G5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_180709</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y0G5"/>
    <dbReference type="STRING" id="675120.M2Y0G5"/>
    <dbReference type="eggNOG" id="KOG0646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025946_1_0_1"/>
    <dbReference type="OMA" id="VTNLHML"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000929">
        <property type="entry name" value="Ribosomal assembly complex component Ipi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="431"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME38804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="526" mass="55828" checksum="C6B05BD499517B8D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y200</accession>
    <name>M2Y200_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y200"/>
    <dbReference type="STRING" id="675120.M2Y200"/>
    <dbReference type="eggNOG" id="ENOG502S3Q3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044743_0_0_1"/>
    <dbReference type="OMA" id="CDGLIYS"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="368" mass="39868" checksum="34089F64E77FC115" modified="2013-05-01" version="1">MSNGKPKPGIPSWQRTAQTRPAPTEDPVYSQPEESHGQQETAAELKEVTVAPVPTEDDVDVDSEENAAKPSESTSNDPQPAAGAQAESGSSFGVSDFETFTQHDRQQSRPVATSSQPTQQTSAAPPIITYPEFLVEAHKPPPLITPSRVLHFTYGAGAVAALLYGTSKWILNPMQDSLSEARHDFLTHSQSKVDELNERLSKIVTKIPGPKKDGTSSEIDADEADSITSDPTELYHRDMGTQTSPPPTRRSSLPGGATQVKKDPVTYQVGALEIMKNHLDELATRSEKTADANKDRQETMNKLSHYLDGLTYGGGSYVWQTSEDATALKSGNEGKNDEIENFKKEIRAVKGLMLSAKRFPARPVAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y323</accession>
    <name>M2Y323_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Branched-chain amino acid aminotransferase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_75365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y323"/>
    <dbReference type="STRING" id="675120.M2Y323"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_1_0_1"/>
    <dbReference type="OMA" id="VGMNAAY"/>
    <dbReference type="OrthoDB" id="409992at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000010">
        <property type="entry name" value="Branched-chain amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME39689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="41608" checksum="022BFC695210CC25" modified="2013-05-01" version="1">MTIDFPPPPVNTIDWDNIGFKVREVNGHIESTYTVQTGKWTPPKFVKDPFLRIHGMAPGLNYGMQCYEGLKASRGPGDDTIGIFRPHQNAERMQHSASYVSMPEVPVELFKQSVHLAVSLNAAYVPPHRTGASMYVRPLLFGSCAQLGLDPPEEYTFVVYVMPTGVYHGVHPVAALILEDFDRAAPEGTGSAKVGGNYAPVLRHSGKAKKEGFGITLHLDSKTRTEVDEFSTSGFLGIYGTPEEGCTIVVPDSKNVIKSVTSDTICQIGKSWGWKVECRPIKYEEISKFTEIAAAGTAAALVPIKSITMRSKNDTFRYQNGSDEPGPAVVKLLAQLKGIQQGKVKDEFGWVEAVREYKPNEYVSDSVAETNGVTIPNELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y4X6</accession>
    <name>M2Y4X6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_72664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y4X6"/>
    <dbReference type="STRING" id="675120.M2Y4X6"/>
    <dbReference type="eggNOG" id="ENOG502QS3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036369_3_0_1"/>
    <dbReference type="OMA" id="NRHSWSF"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000001">
        <property type="entry name" value="MIPC synthase subunit (SurA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME43324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="341" mass="39655" checksum="0E4B85D72F3387F0" modified="2013-05-01" version="1">MRRPVAIFLVINLAVVLFLIYSVWTLLELLVITGIEDAITRAELPAIGAEDKITAKPLIPKIIHQTYINTSIPEVWQDAQASCKELHHKSDGWEYKLWTDKMSVEFIADEYPEFLETFKGYRYPIQRADAIRYFVLDRFGGIYIDLDDGCNRPLEPLLSYPSFVRKTVPTGVSNDAMGAVPGHPFFKRVIQELQRYDRSWILPYITVMASTGPLFLSVIWRHYSDEGFNVGNGADGGRIRIIFPEEYNSHPWSFFTHHLGNSWHGYDVQLIFWMARNWVLLTVIGFVVGIGAILLGWWSYHRYFLAPTDIPQWKKKSVRDRLAFWSNRHQSEYELVNRHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>M2YHV5</accession>
    <name>M2YHV5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_75971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YHV5"/>
    <dbReference type="HOGENOM" id="CLU_1796427_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="144" mass="16369" checksum="88AF2C0B4F449C00" modified="2013-05-01" version="1">MASPGHQFQYPDKLASVPQRGDRRHQLWCSLPGSLQDCCLMERYRELWLGQVSVGQAFRSAAMSHLRCLDRLSNISTLSACQIHENRFTLPLNCADVDLETVQTILLSNGPKQSTNRDGLFEHSLQVEVRNRPRRSSKSMARNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIW6</accession>
    <name>M2YIW6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_139710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIW6"/>
    <dbReference type="STRING" id="675120.M2YIW6"/>
    <dbReference type="eggNOG" id="ENOG502S35E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083103_0_0_1"/>
    <dbReference type="OMA" id="YNPSKNR"/>
    <dbReference type="OrthoDB" id="61321at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09620">
        <property type="entry name" value="CBM9_like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004029966" description="Carbohydrate-binding domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25550" checksum="9AB960FFA0A2810E" modified="2013-05-01" version="1">MALKHFIFVATAAATALAVPSLDVPRCPERSTITYDKSVPDLKDFPLTQVELCYDDTFIRIDFTAYNETNFYYNKTLTTNDPIFNYEVQETFISRCISDPTTYLEFEVAPNNVTFNAFIYNPSKTREEGAPFDTFYIQDPVKDKLTVETTVDKEQETWTSKAQIPLKLFNVEDGKAKGTEWRMNFFRIVCNAETCPNEQLGAWSPPDAASFHKTPFFGKVKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIY0</accession>
    <name>M2YIY0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_75538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIY0"/>
    <dbReference type="HOGENOM" id="CLU_1825236_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="141" mass="14804" checksum="5EA3393B159420A9" modified="2013-05-01" version="1">MAGLPIASAPGHVCCDETPLGGTSRSFELQWQCAAIDASRQRLESIEVVIGIRRLRSTAVWTCSLARRHLIKPSRHCSAPTAGKADSMCAPIAGSTVPCAPLVTVMAYWTKPNVGVINAAMPAGRPEVLGKSSAFAEEATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIY7</accession>
    <name>M2YIY7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_180879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIY7"/>
    <dbReference type="STRING" id="675120.M2YIY7"/>
    <dbReference type="eggNOG" id="ENOG502RXC9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_1"/>
    <dbReference type="OMA" id="VNWFRDE"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF25">
        <property type="entry name" value="NMRA FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME38900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="305" mass="33269" checksum="C36F87E2C12AC19A" modified="2013-05-01" version="1">MSKNIIVTGATGKQGGALIEQLANNAEFTLIAITRNATGAGADKLKSKGSNIKVVQGDQNDCPALFEAAESQASGPIWGVYSVQIAQGHGPASGSGDETKQGCDMIDEAVKAGVKHFVYSSVERGGDERSWENPIPSVGHFATKHNVEQHLKKKASSMGWTILRPVAFFENLTPGFPAKVFMAAMQSTVGEKRVQWISTKDIGFFAALAFKKPQEWNHKAMGLAGDELNVNELCDKVRDNTKTTIYPTFWFLGGVLKYMVAEIGSMINWFGAEGYKADIAACKRVHPQMMDLETWLKTESTFPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJD6</accession>
    <name>M2YJD6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="8">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_110589</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="8"/>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJD6"/>
    <dbReference type="STRING" id="675120.M2YJD6"/>
    <dbReference type="eggNOG" id="KOG0988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001366_0_2_1"/>
    <dbReference type="OMA" id="DDYLVIW"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140720">
        <property type="term" value="C:subtelomeric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033562">
        <property type="term" value="P:co-transcriptional gene silencing by RNA interference machinery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070317">
        <property type="term" value="P:negative regulation of G0 to G1 transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="9">
        <location>
            <begin position="412"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP C-terminal head" evidence="10">
        <location>
            <begin position="1008"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME39040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1155" mass="131486" checksum="F7838BA1E1C68AA1" modified="2013-05-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJZ2</accession>
    <name>M2YJZ2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_38437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJZ2"/>
    <dbReference type="HOGENOM" id="CLU_637822_0_0_1"/>
    <dbReference type="OMA" id="MPNLLWW"/>
    <dbReference type="OrthoDB" id="3650832at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004029923" evidence="1">
        <location>
            <begin position="20"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="430" mass="47598" checksum="E6F6C8F19FD2460A" modified="2013-05-01" version="1">MAAISSVLLVLLACFLVSSLSTMQEDFGPIHARDIAAVTGVGMGNFSGTGSTRNATQDGIGRQFSEVLGMDEEQAAAAPYSLQQKDTLPSQAFFDSNEWEAIEDEADYDMRATMPELIPLHGLRRLEGLRTNTRRTTVSFNLDSGTWRHTRYVQNKPYVGPYALVRGKSVLTIQRGAPQQTYAYFEMAFDPKGLMILTGARSPQYQIAAMGLHQPLPAVSKWSDVAFLQEMLYNGDSAMRTGSELAAPQWILVKDIYGPRDTLAVISRCLRFHGWTSPHLPDWAHRVTFPIGSASYDAILGTQNAAGVAWFLIEHKYKYGTTMLASVTVYSDLKINTGSPQGDHPVIAMPDVNPQLGSTEMPNLLWWSGSLELAITGSRANRGFNLVEIRDVNRALEQGNRYSILHQDQWANPNFQAAPSPWKFSLKPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKU5</accession>
    <name>M2YKU5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_180206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKU5"/>
    <dbReference type="STRING" id="675120.M2YKU5"/>
    <dbReference type="eggNOG" id="KOG0868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_5_3_1"/>
    <dbReference type="OMA" id="CVRENAC"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="92"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="271" mass="29998" checksum="7E1C4B65ECC67385" modified="2013-05-01" version="1">MSSSSQAYFLHDHPVSSYAQKVRMALRLKGLAFESKTPPNLGSGEANKSFSKANPRMEVPALIDGEFAVFDSTAILMYLEDKHPEEPLLPKDPKARAEARMIEEVCDTHYEAVNWSIGEINWFGRATGSEKERLIAAAVEQTSQLQEWLTTKLGSQPFFNGSSPGYADISVAPIVNRSVHYGYGPKEGSPLRLWHKRISDVPAISETFAEMTAGAKQMAGSGAATFAKGSGRRREYRDHRLEWMVKNGALGIVQNGVEEDTVRFGWPHPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2YN63</accession>
    <name>M2YN63_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_25341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YN63"/>
    <dbReference type="STRING" id="675120.M2YN63"/>
    <dbReference type="eggNOG" id="ENOG502SFTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2196902_0_0_1"/>
    <dbReference type="OMA" id="MRFRRFK"/>
    <dbReference type="OrthoDB" id="3944319at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="6"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="108" mass="11758" checksum="415298A9FAC6C2FB" modified="2013-05-01" version="1">MAPVTNELFLLSCINHANNGRIDFKAVAQECGMNTPGAAAMRFRRFKEKHDTSLLNSASSLAAAQNGEGGDEDSEVPAKKPTPKKKATPKKRKIKEDHEVVVKAEPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2YNJ5</accession>
    <name>M2YNJ5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_25508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YNJ5"/>
    <dbReference type="HOGENOM" id="CLU_1434418_0_0_1"/>
    <dbReference type="OMA" id="QVTWNAR"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21276" checksum="91B3F0B0D09BC928" modified="2013-05-01" version="1">MAATTELARRVQTLPQELRESVLHYTLTTPDTVTIDRTYRPLPQLQVDGATRQTTSRSLYGPSTAFVISNICLCNQWLQSLSVAARQSIQNIDYIRVVGDNSDQIVDGVATSGYRKLFSNVGKWYKLLSRQVTWNARRESIFVQATRHGQGWDLDGGILGDEREGDEVREGESENCRSVISCQNSDPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2YPM9</accession>
    <name>M2YPM9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_54350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YPM9"/>
    <dbReference type="STRING" id="675120.M2YPM9"/>
    <dbReference type="eggNOG" id="KOG0888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_6_1_1"/>
    <dbReference type="OMA" id="QHYGEHK"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="41"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME43576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="190" mass="21319" checksum="F1C34E9FE2543D40" modified="2013-05-01" version="1">MSSQDTPPEPPIFKYLNAKDRAYLTTVLRQKEQQETAKMTSEQTFIAVKPDGVQRGIVGEIISRFERRGFKLAAIKLITASTEHLEKHYADLSDKPFFKGLVTYMASGPICAMVWEGREVVKTGRQILGATNPLASQPGTIRGDFAIDVGRNVCHGSDAVESAQKEIALWFSKEEVQSWKSAQHEWVYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2YPR1</accession>
    <name>M2YPR1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_72846</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YPR1"/>
    <dbReference type="STRING" id="675120.M2YPR1"/>
    <dbReference type="eggNOG" id="ENOG502S30T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072104_0_0_1"/>
    <dbReference type="OMA" id="YTTRAWV"/>
    <dbReference type="OrthoDB" id="5377273at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="174"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME43611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="333" mass="36423" checksum="934BCFFE09945DFC" modified="2013-05-01" version="1">MQALHKLAGVQEASDSGAQPQAPIPVRTNKELPRPPPIPQDEPGDVDALSTRSSAKRAAVPDNRRASQKSIRSNKSKKSFASQRSASGPEISTAVDLSEYPPSPRPPQQFDQSSTGAPDNAIPRASAESNNAEGDDVAADDLSEEFQWGPSHPCFPHPNPHCAPDSDERATTRVIRVRRDWLAAGDLFPQYANLYPEILDPLITDAEFRALVTSVNGMLESTLSPYTTRAWVDSILGVITGYFWEDLGWTGAKQGEKALEAFLDGWNQDRANEGRDVRVVQLRRTGFMSMDFVIPDPGIDQPRSQSGEEEEEEHEQNAQDVLREEGGGIGPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBK8</accession>
    <name>N1PBK8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_57536</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBK8"/>
    <dbReference type="STRING" id="675120.N1PBK8"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OMA" id="FFEEATF"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME38452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="58587" checksum="EB7DB0B48523770D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCA3</accession>
    <name>N1PCA3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_178667</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCA3"/>
    <dbReference type="STRING" id="675120.N1PCA3"/>
    <dbReference type="eggNOG" id="ENOG502QVWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_4_2_1"/>
    <dbReference type="OMA" id="MTYISIA"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="35"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME39842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="441" mass="47460" checksum="1748B24E21B90AF9" modified="2013-06-26" version="1">MLDKDTESPERDGSRYDPISDPFGDETNAEVKYRTLTWWQCSLLMIAETISLGILSLPSVMATIGLVPGVILLVILGMIASYTGFVFGQFKQAFPHVANMADAGEVLMGAFGRELIGTAQIILLIFVLGSHLLTFTIAWNTITGHATCTIVWGVIGLVVFFVLSLPRTLKNVSYMSIASFISIVGAVFITVIAVGVQKPAGGVVEATKSPSFATGFNSAMNICFAYAGHMAFFSFIAEMQKPEEFPKALAGLQSAAISLYLIAAVVIYVYVGADVVSPALGSAGPVVKKVAYGIALPTIVIAGVIYANVAAKQIYLRIFRGSKHIHEKTWTGVGSWTAIIAILWIIAWVIAESIPVFNDLNSLIVALFVSWFTYGIAGVFWLFMNYGKWFSNWKKTCLFVLNSFIFLLGGVICGVGLYATGKAIHDDTGKGASWSCADNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCC9</accession>
    <name>N1PCC9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_75855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCC9"/>
    <dbReference type="STRING" id="675120.N1PCC9"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_608344_0_0_1"/>
    <dbReference type="OMA" id="MQGWARR"/>
    <dbReference type="OrthoDB" id="3649706at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109293" description="C2H2-type domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME38468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="450" mass="49793" checksum="D847B30803E1743A" modified="2013-06-26" version="1">MSSFNSKSTILFLLVITLATFARANPNGPNYDSMDWNWDLFDSVGGQFAAGLVACNQFNPMIASPVVGSSRVAEPPRRRSPSEPQPHWNNVRAPSAAPRPGFFSFTDIEYASVWEARSQSQEVVMASSMSLYTHSAPDDRSHHHVSAAARRLFRPQYQQSISRELDQAAGVAAHPPSNPSCEQCPSLDASNMYGYPGAPQAQTPAEQRTKQAQSHAENERETETTAQRDFRTYHAPPLETEVSKSMPLLGTPFCATGPYLATPSPRMLPQEITSNPKYHLGMANGAVGNMQGWARRASAIGIPTGLSINTTHLAPPEDRGANPSPTSASTTGSSTRPGSRRSREEMVGNFVCGYCKAGFLSQGELTHHLRSHTPYMSRQHVCLVCEKRFQYKKDLGRHAPKHDPNRKKYYCSFQGCKYFTKGFGRQDHLDRHLATQHRVDTPQQASHRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCP4</accession>
    <name>N1PCP4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 15">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">pdi1</name>
        <name evidence="17" type="ORF">DOTSEDRAFT_137596</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 15"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCP4"/>
    <dbReference type="STRING" id="675120.N1PCP4"/>
    <dbReference type="eggNOG" id="KOG0190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025879_5_0_1"/>
    <dbReference type="OMA" id="FFGMKKD"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000154">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000185">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005141837" description="Protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="17"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="326"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="46"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="386"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME39794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="527" mass="57714" checksum="941EC44F47DCE7C0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE39</accession>
    <name>N1PE39_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE39"/>
    <dbReference type="STRING" id="675120.N1PE39"/>
    <dbReference type="eggNOG" id="ENOG502R3N6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007899_0_0_1"/>
    <dbReference type="OMA" id="PYLDEMS"/>
    <dbReference type="OrthoDB" id="3199516at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1044" mass="115453" checksum="5AC550FA34E0CC00" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEP0</accession>
    <name>N1PEP0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_37577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEP0"/>
    <dbReference type="HOGENOM" id="CLU_1331937_0_0_1"/>
    <dbReference type="OMA" id="TILINCW"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="206" mass="23498" checksum="96533DFC1DBA6528" modified="2013-06-26" version="1">MCDEETGDLECIVPFEAVTDLARSVALRLEGDKDAFEILLFWLTKRCVPSHDIDRHGEGDDHQEIFTILINCWLIGASYQIRAFQDAVMLELLKLLGPFSVSLITLRHAPKQSRPGSSLRAVMLEELTWSIARDRFDHKDLAVLDDTPSLLSEYIPTPRRHSGHGEEDWGERVENGKWKKFLFGHGPPKHWFGRRETASGSSEEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PES6</accession>
    <name>N1PES6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_36583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PES6"/>
    <dbReference type="eggNOG" id="ENOG502R94A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484868_0_0_1"/>
    <dbReference type="OMA" id="TEAVCRI"/>
    <dbReference type="OrthoDB" id="3440338at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="504"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="562" mass="63112" checksum="3FFFBC364576AA1C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF82</accession>
    <name>N1PF82_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Multicopper oxidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_178384</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF82"/>
    <dbReference type="STRING" id="675120.N1PF82"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_7_2_1"/>
    <dbReference type="OMA" id="HGHHFYI"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04205">
        <property type="entry name" value="CuRO_2_LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13910">
        <property type="entry name" value="CuRO_3_MCO_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="85"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="211"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="475"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME41042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="64727" checksum="0AEDF566270D3EDC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFC3</accession>
    <name>N1PFC3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_55905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFC3"/>
    <dbReference type="STRING" id="675120.N1PFC3"/>
    <dbReference type="eggNOG" id="KOG4234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058463_1_0_1"/>
    <dbReference type="OMA" id="KSAIDDC"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35168" checksum="CCE7825A12B7415D" modified="2013-06-26" version="1">MAFKPTYHNGVDEDSDSDESFHSFREDDQPKANTAPPPASRKPAPSENEARSAKPVIECFEPEEEAKLLAESNSIKGDANQLFGKGSFENAIQRYDRALASCPSYLDYELAVLHSNIAACHLKLEEWKECVESADKGVDCLERLEPLPVVKRPNAKRENADGKAIEEPEPEDGVEEVDDDLEERIENLKKSGRTLDEVRKLQIKLLMRRAKAKTELRGWASLQGAEEDYHTLLSSTMMPCLTTTDKRQITEAARKLGPKLNEAKDREMAEMMGKLKGLGNSILKPFGLSTENFQFVKDEKSGGYSMNFNQGGGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFF5</accession>
    <name>N1PFF5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_91122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFF5"/>
    <dbReference type="STRING" id="675120.N1PFF5"/>
    <dbReference type="eggNOG" id="KOG3730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015023_0_0_1"/>
    <dbReference type="OMA" id="ENMICKM"/>
    <dbReference type="OrthoDB" id="10255570at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="190"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME41102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="794" mass="90391" checksum="E0FF8CDA926FE030" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFJ1</accession>
    <name>N1PFJ1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFJ1"/>
    <dbReference type="STRING" id="675120.N1PFJ1"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_17_1_1"/>
    <dbReference type="OMA" id="HLPWDPI"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27007" checksum="06C13CEC0A9788B4" modified="2013-06-26" version="1">MSTHGSLVVFGSGPGIGRNVAALFAERGFSQIVLLSRNTDRLKEDADFVKSKASSAEVINVKIDLSSSDSVRKALEEVDDRLGNAPVEAVLYNAARVGKSEILKFPAEDLKQDLQITVVSLYITAQWALPKLLDTSKNSSYHTPAFLVTSGGLYKNPFPNLFSLSAGKAGQYNLVHSMHKEFQPQGVHCALIVVEGFVKDDAKVTTARHIAEKAWELYDQPKEKGDLDVHIVDPDYAKAMGTRNSDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFL4</accession>
    <name>N1PFL4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_134513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFL4"/>
    <dbReference type="eggNOG" id="ENOG502R964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_647273_0_0_1"/>
    <dbReference type="OMA" id="DYASECE"/>
    <dbReference type="OrthoDB" id="3825471at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="48492" checksum="4B875332D59CDB0F" modified="2013-06-26" version="1">MADKPRPSIEAPSRALGSTWIHLYEGCLWPVVICDRSTVPEFFFKLRSKEYHIPAILLGKHIYVWVTDATVQEYNPNYDYASECEAFEHRDVPKSDDEDTRTERLRRMAFEIEAPHLRDNEYWHNYIISESNVRSLERKMKRPHSTDDDEIEIVGAERQSNTSSFSSGLPHSRVKKTTRSNHAQSRHIIEITDHEESDDDDVSFLTDFTSKPDCRILLGGHGQSIIASRARCAESDYLQARERYDEAVGEHIIDLNDDQRAVELDLAHVELQRIEIFLSSGDVGPQFLKDPDEYRPFGKLSEEEKENAAHQLALAFVTASKLQHVKLQGLIEKKLNALYPLPAMSLLTVALILARMPPTGIMTHPEQRVGNWLIASLAGQFWHLAKHHTGTFQRLLQGNDELRDGVYHRMQMNADEGLQGGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFM5</accession>
    <name>N1PFM5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pkr1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_66178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFM5"/>
    <dbReference type="STRING" id="675120.N1PFM5"/>
    <dbReference type="eggNOG" id="ENOG502S6V3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068499_0_0_1"/>
    <dbReference type="OMA" id="VKLWEDI"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251:SF1">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19554" checksum="CE74A358A6AB9394" modified="2013-06-26" version="1">MANFLANLWESVFISGPTPTLLVATNITFGALQLLLAGLLFATYSIHFAILSVLSGGLWWSINWFAKELQQAQAKEAEADRLRRRQKQDEADDEGEDTETEDAGRMKESLTYEPTTGDERIREEILDAMRTSGAAASTGSQPVPGSVQTKQRKAEEGSHSASEISTDSEWEKVDETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG31</accession>
    <name>N1PG31_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG31"/>
    <dbReference type="HOGENOM" id="CLU_1618969_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="164" mass="18958" checksum="438026228E985217" modified="2013-06-26" version="1">MQAGAGCFWRRFPDDSSCNCNIGSFAPVSAAAYLDFPPFLRLVFCFGDNKLAQPVEAFGKSLKFEALQHRQGRRIAWARWFTRRCFEETSCLWQGHTSSGIENCNNRRTVALRPSSVKPVARPENSSRYRSWQRCRRRAWNRIAERMPSQQAAVSSCWNMSSWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG37</accession>
    <name>N1PG37_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_74899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG37"/>
    <dbReference type="STRING" id="675120.N1PG37"/>
    <dbReference type="eggNOG" id="KOG3979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009808_0_0_1"/>
    <dbReference type="OMA" id="CVWYFPL"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000031">
        <property type="entry name" value="Calcofluor white hypersensitive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="4">
        <location>
            <begin position="278"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="3">
        <location>
            <begin position="452"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="5">
        <location>
            <begin position="683"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME40251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="949" mass="106295" checksum="54D4E206AA1F0E53" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGM2</accession>
    <name>N1PGM2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_90163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGM2"/>
    <dbReference type="eggNOG" id="ENOG502SUUC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123909_0_0_1"/>
    <dbReference type="OMA" id="GYPVNWP"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="178" mass="20002" checksum="E114DDF46F8F097D" modified="2013-06-26" version="1">MSQETTDISQTISIRPRRTEDLASCIGILNRVYDLDGYPVHGVSNASSFLDFDALEQAFVAEYHGKIIGHVAIGEANDSDVAVQLWRTQHPATPIAVLERLFVDPRSRGSGTAAKLIEAAEAWSNERRQRLVLFVLEKDRVAERLYRRLGWEHFGTTTFRFGESKTMSALCFVCPTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGX4</accession>
    <name>N1PGX4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_37537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGX4"/>
    <dbReference type="STRING" id="675120.N1PGX4"/>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1354588_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME40780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="202" mass="22804" checksum="280358EF3ECA5E36" modified="2013-06-26" version="1">MGEDSIDQIPKTLLHTLTQQTTLLRLSIWSSSRGYRSIRLLGSFIAIVPTSDGVNKGIARRKKKVLKDNIMGITKPSIRRLARRGGVVRISDGIYEETRVSLKTFLTESMDHQNRKTVTVIDAIHALKSMGNSLMAYKNISRTSLKGDEEHEQGIKSDDNEESGMQLGSGRWNDIHGPLRRRSLTAFWTVDQMRAEHCLINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHF7</accession>
    <name>N1PHF7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_56045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHF7"/>
    <dbReference type="STRING" id="675120.N1PHF7"/>
    <dbReference type="ESTHER" id="mycp1-n1phf7">
        <property type="family name" value="Canar_LipB"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSW8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029537_0_1_1"/>
    <dbReference type="OMA" id="LVCPWLA"/>
    <dbReference type="OrthoDB" id="4605274at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053228">
        <property type="entry name" value="Stereospecific_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574:SF1">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109844" evidence="1">
        <location>
            <begin position="24"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="457" mass="48232" checksum="CBDA55FE1C1D4AB5" modified="2013-06-26" version="1">MPAYQSRMVRVAVGACLAATAIATPTPVEREAVTPAAVLERAASSTPITNQNQLDQAFSSVPADVESIAAGVSVLEAIFTNIVPAPGPTAVAQLQQELKTIYSANPQDIFKSGADILLAGLAGGDYEDLVEAFTVENNASNVNPVVPGIYDISGDAPYDISEDQLRQVIYIPPEYTYGKEPPVIFLPGTAVLAGTNFGPNYGKLFKQNHIADPVYLNLPGMNLADIQGAAEYVAYAVTTISWSAGSVDAQWALKYWPSIRPKYDNKISISADYHGTILAQSLCPGTVTLGSDPAICQQRYNSTFIRTLRNNGGDSAYIPSTNVYSIFDEIVQPQEDPNASGFLNDARGVGVTNVELQSVCGAVLPGGAFYNTHEGVLYNALAYALAVDAIQNGGPGQLSRVNPALQCAQFATPGLSLADILATEANIPIAVAAVIAFEPKTADEPPIKAYAQKDTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI25</accession>
    <name>N1PI25_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_73991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PI25"/>
    <dbReference type="STRING" id="675120.N1PI25"/>
    <dbReference type="eggNOG" id="KOG0797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006974_0_1_1"/>
    <dbReference type="OMA" id="AYKCMWA"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000232">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.580">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="728" mass="83081" checksum="DAB39F5621976568" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIP3</accession>
    <name>N1PIP3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIP3"/>
    <dbReference type="eggNOG" id="ENOG502SQZA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038508_0_0_1"/>
    <dbReference type="OMA" id="RYEETAY"/>
    <dbReference type="OrthoDB" id="5401654at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="427" mass="44996" checksum="21BA7FE0C6CD0A5B" modified="2013-06-26" version="1">MAPDINSLPTSPRLDRSNPISPSLSTNASRRASAVMGPPGQPASATLPPTPLQPRTPNMSNNDQVPMRHPRPLTAAELYLECEKEQEAVVNRLTRELTALRAQSASVASNASVSSNSTSASLLPVDISGPNPTHQMTGATHPTPSRRHRSSSSVSTRSFNTPSTNMSQAGSTISNSSTQPQTNHAANVPLHGVSQASAERAAAATGHHREPLSRQPSINASGRSTPARHSMEIPRHGGTLYTLPHRPSLSRGPSENTLSSNHAQVGTPGPVPQHLPSPAQSPSSLNVNAAMQHYVDTASYRNEMEIVKAENEQLRQRVRALERALRQRRRDSSASNVARPDPTGSTRPTRENSISERIPSMTSPLPSAGLGVAAWAANTGGVGGVAGPRERSESQSTTASSRRGLGVTEDEVRVGESASNAGVGRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIT0</accession>
    <name>N1PIT0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_98591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIT0"/>
    <dbReference type="STRING" id="675120.N1PIT0"/>
    <dbReference type="eggNOG" id="ENOG502RYEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060788_1_0_1"/>
    <dbReference type="OMA" id="KCVEYDP"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="45"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="213" mass="24102" checksum="D12FAEFC4A66C27C" modified="2013-06-26" version="1" fragment="single">LSSPPPPAQFRPSVSFDTFSNPSASDFSLTLNRKHRDYVYTKRSRTFLCGTDTNEYSDTALEWLIDELVDDGDEVVCLRVVEKDSKEAAKWAGGQGEKGYRREAQRFLEEIEKKNTEDRAISLVLEFSIGKVHDTIQQMIRIYEPAILVVGTRGRSLTGYQGLLSSGSVSKYCLQYSPVPVIVVRPGSSREKKKRKRLQDPSRSGYRDILDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIV1</accession>
    <name>N1PIV1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_45865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIV1"/>
    <dbReference type="HOGENOM" id="CLU_2722204_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="72" mass="7728" checksum="A9237AEA0D5D73B2" modified="2013-06-26" version="1">MSRLEIPGIPPVGARGRQSKEQGRHSCSSRRAPAASTATSQRVSFRQRKDAPVSATDEADEAHVVVQEQVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJF7</accession>
    <name>N1PJF7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJF7"/>
    <dbReference type="STRING" id="675120.N1PJF7"/>
    <dbReference type="eggNOG" id="ENOG502R91B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_936976_0_0_1"/>
    <dbReference type="OMA" id="NSTCNAG"/>
    <dbReference type="OrthoDB" id="3624420at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109891" evidence="1">
        <location>
            <begin position="18"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="297" mass="32169" checksum="2C9C211F33F4D404" modified="2013-06-26" version="1">MQALTFLVAALTALSTALPVDTTVPCTAAYEEYMRNASAGFGWQLAGAAKNTDELDATCNELKNGDNCKWADEGLVVDYIAAPVCNTSTAPNAELALPIIVQYNTKVFATLLLNSFDSSNKTTWNYLCDNLRFKKIDNFLLDSQTLINSTCNAGSSKLNPQPFEALGQPNLTALADYKEAASKLFAWEYASFATSSSQLNTMCAHASAKATKWVHLQLDPACVEQTICSFENPLSAEDVKTKMREWSSKQYVTVLRNVSNAPGYQRWLCNNLEADAMSAAGLDGDYVKGVVCGDVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK33</accession>
    <name>N1PK33_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_37007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK33"/>
    <dbReference type="HOGENOM" id="CLU_1749599_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="149" mass="16246" checksum="3F85DD4C3445DD88" modified="2013-06-26" version="1">MGCELSLEICKQPLSYLDPEAGMIEIADDSSWRYNTEGVAVNCTIEVGPGWEAPIKIIRDCRVTSALDSVRVSDDADEDICGQNIRCSSLSRHSIRQSARCATPTNKLATEDPIVAVDIPAYIMSRLAIAGKPLKYSPFAEDAVRRSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKF2</accession>
    <name>N1PKF2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_71601</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKF2"/>
    <dbReference type="STRING" id="675120.N1PKF2"/>
    <dbReference type="eggNOG" id="ENOG502QQ7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019691_1_0_1"/>
    <dbReference type="OMA" id="CDGHEPC"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="520"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME43821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="591" mass="66146" checksum="3D71B56F27D22D16" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKR2</accession>
    <name>N1PKR2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_74077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKR2"/>
    <dbReference type="STRING" id="675120.N1PKR2"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005210_4_0_1"/>
    <dbReference type="OMA" id="IFVWGTG"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101024">
        <property type="term" value="P:mitotic nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031291">
        <property type="term" value="P:Ran protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032888">
        <property type="term" value="P:regulation of mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="158"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="160"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="215"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="298"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="351"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="409"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="466"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME41901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="600" mass="63009" checksum="5AF38757B8D947F3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKR4</accession>
    <name>N1PKR4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_53286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKR4"/>
    <dbReference type="HOGENOM" id="CLU_1245324_0_0_1"/>
    <dbReference type="OMA" id="IDWAYFD"/>
    <dbReference type="OrthoDB" id="3649380at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="222" mass="24382" checksum="6D70202CA9658540" modified="2013-06-26" version="1">MPRQSRRYQFVTETPGNALREAFETGDGESQTATVPIPSERLHTIETHVDNLNQMVQALQAQRHPDNRQLGAQRSTNGQDVALSEIPALQSMHSTCYVELACLTSMCDEVAELGEVLSNQARYLLGSEQASTVSAESEPEYQADFDSRRPSMTQAHSSAPSSLQTSTGPQLTPLNPMAPTASNVPWDASSDVVMDPTGIDWAYFDHILQQNGFQMPDQASQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL92</accession>
    <name>N1PL92_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_34750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL92"/>
    <dbReference type="HOGENOM" id="CLU_1713208_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="153" mass="16900" checksum="B80212ED649E84D4" modified="2013-06-26" version="1">MCIEGMPGLPPPRKLASRRSNASTRLLRGPAIASIVAVSDRTRIACWSARLEDCDITRQPPEWAPRHEVTSSLPFSTRIHDQEEWRPSLQKPAWAAPPWPVTGHTRRELSKLPGQCRQALDTSFYAIQAAAGACCVLTIKADYLPCASWILAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLV8</accession>
    <name>N1PLV8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLV8"/>
    <dbReference type="HOGENOM" id="CLU_2223212_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="106" mass="12148" checksum="4EA85DB83DA91EB3" modified="2013-06-26" version="1">MLEKDRKRVEEHETKRPQLQHALDVEGEERSQLRRDNANSEQRSISLVEDNAAKLKAQAEEYQQKTAAHQGEQETLLARLQAAEKKADESAQQLEAARQARATEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM03</accession>
    <name>N1PM03_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_53599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM03"/>
    <dbReference type="HOGENOM" id="CLU_1030686_0_0_1"/>
    <dbReference type="OrthoDB" id="10472436at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="270" mass="29576" checksum="B39F460408D24828" modified="2013-06-26" version="1">MPDPPLPQNLQELSAWIARNGPYYNIDHPTADFPDVGNFMIIELEAALLTGIENIKTARERLRTVPGPHQAFVECADLAATSRSLVLSIDRSGIMDINRSTAMKLVISAKYQCSLSYQNVLTFLAIGTQKLTNETRKVKAAVSRYQREVQAKEMLMSMLQSSISSSPASALSNGDDDDWFVVSSETHKPASTPGVEREGSKSDTLAQEMLYEEIEVRLAAIPGSEKGELAGEEIGGLPGTRYEPEMRVVEEERARQGTIVVAMENGVTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN87</accession>
    <name>N1PN87_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase Hos3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hos3</name>
        <name evidence="3" type="ORF">DOTSEDRAFT_71614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN87"/>
    <dbReference type="STRING" id="675120.N1PN87"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001880_0_1_1"/>
    <dbReference type="OMA" id="MTHGLTH"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09998">
        <property type="entry name" value="HDAC_Hos3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000011">
        <property type="entry name" value="Histone deacetylase HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="256"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="817"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="886"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1206" mass="129610" checksum="D2A8FC8F8811ADE6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNE6</accession>
    <name>N1PNE6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_53542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNE6"/>
    <dbReference type="STRING" id="675120.N1PNE6"/>
    <dbReference type="eggNOG" id="KOG4141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011431_4_0_1"/>
    <dbReference type="OMA" id="NLHRHAD"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME44443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="591" mass="63052" checksum="071C6E7195905DDA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNI2</accession>
    <name>N1PNI2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1783-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNI2"/>
    <dbReference type="STRING" id="675120.N1PNI2"/>
    <dbReference type="eggNOG" id="ENOG502RZQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092488_1_1_1"/>
    <dbReference type="OMA" id="EFLIHEW"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21497" checksum="EDA1032D8B29B1C5" modified="2013-06-26" version="1">MLPRPRIRPTGLFQTLKISNQNGARRTLVAAPKAGSGPLMERRADRALPSVSTGDNRWLKTMPIFLFIVVGSTLAIFNYQKQSSSVVSSTLYALRTNDQARSILGDEIYFASQIPWISGELNQLHGRINISFWVKGKKAKGLMRFKSERKTRMGMFETLEWSLQPEGGEKISLLDGSERDPALNQKGETVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNI7</accession>
    <name>N1PNI7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_130307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNI7"/>
    <dbReference type="eggNOG" id="ENOG502SUAV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2704772_0_0_1"/>
    <dbReference type="OMA" id="FSNYYCS"/>
    <dbReference type="OrthoDB" id="3621151at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="73" mass="8568" checksum="F2183F6A6C098A56" modified="2013-06-26" version="1">MCKYTYLFYFCGCDYYIVWDSSESCANRSLSGYSVDVWTTDMCSSKEAECLGRSKYVCRECAEDHTLEYELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNP1</accession>
    <name>N1PNP1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNP1"/>
    <dbReference type="HOGENOM" id="CLU_2158296_0_0_1"/>
    <dbReference type="OMA" id="LDQGDWM"/>
    <dbReference type="OrthoDB" id="10431601at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="111" mass="12415" checksum="508FEF2B0689847E" modified="2013-06-26" version="1">MTGPQIVRRQLGSAVKQHPRSSCYASRAAAILQLDQGDWMYLRREELERLIQRQDSEERMIDESASEITRQASQEPRSSKPLAGLAVLKSAGKMLATVFRIKSVGVNTESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNY8</accession>
    <name>N1PNY8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YjgF-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_129332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNY8"/>
    <dbReference type="STRING" id="675120.N1PNY8"/>
    <dbReference type="eggNOG" id="ENOG502SQAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_4_4_1"/>
    <dbReference type="OMA" id="RHYIVKE"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857">
        <property type="entry name" value="BLR7761 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857:SF1">
        <property type="entry name" value="YJGH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17137" checksum="E5C75ABEEF63219C" modified="2013-06-26" version="1">MASSRGFDDKPRAFNPEGVPKPPPTYNQACITPILHASKFITLAGQTGITPETGKVASTSIAEQAKQAYKTVHTALRAAGAYPRDIIHVRHYIVTETGDPEVDKVDVVERGWGGHWMEFMDREAHGHRPPDTVLGVASLAKRELLYEVEVWAIVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP38</accession>
    <name>N1PP38_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_71818</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP38"/>
    <dbReference type="STRING" id="675120.N1PP38"/>
    <dbReference type="eggNOG" id="ENOG502QRH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008719_5_1_1"/>
    <dbReference type="OMA" id="HHHGAWT"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME44130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="648" mass="73494" checksum="F54F70D4F7311AA5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPY9</accession>
    <name>N1PPY9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_87834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPY9"/>
    <dbReference type="STRING" id="675120.N1PPY9"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OMA" id="AKRNSIY"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF265">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="445"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="544" mass="60503" checksum="0C27DF64984AD412" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQB8</accession>
    <name>N1PQB8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_52852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQB8"/>
    <dbReference type="eggNOG" id="ENOG502SIR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_4_1_1"/>
    <dbReference type="OMA" id="LHGHGTS"/>
    <dbReference type="OrthoDB" id="3631038at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF7">
        <property type="entry name" value="SERINE HYDROLASE FSH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="283" mass="31732" checksum="897E130C8DFD1C97" modified="2013-06-26" version="1">MRFLCLHGSGTSAQIIRYQLSALKTALGPSHTFDFLDAPCPDTAGPGVGPFFDPPFYSWWPKPTKDNIVTAIKALLVRISSSDKTYDAVVGFSQGTSLLTATTIYCQNENIPLPWKGAICICGGIPYELLECYMPVSEKAKDLVVQTRRDLDASSDRNAKKIEEMMETGNRVDLWDYPSTLWDGKEVITRDPWVLPDVDEKDVYGLDVSNLPEKVRLSIPTAHIYGHKDPMSAFHVQLATLSDAGRRIVYDHRGGHEVPRVPRVVQDLVKVVEWLEKRISENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQS3</accession>
    <name>N1PQS3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial resolvase Ydc2 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_72234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQS3"/>
    <dbReference type="STRING" id="675120.N1PQS3"/>
    <dbReference type="eggNOG" id="ENOG502S4DK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042191_0_0_1"/>
    <dbReference type="OMA" id="GITWLEW"/>
    <dbReference type="OrthoDB" id="5552842at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000402">
        <property type="term" value="F:crossed form four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16963">
        <property type="entry name" value="CCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039197">
        <property type="entry name" value="Mrs1/Cce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015242">
        <property type="entry name" value="Ydc2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072:SF1">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09159">
        <property type="entry name" value="Ydc2-catalyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial resolvase Ydc2 catalytic" evidence="2">
        <location>
            <begin position="54"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="356" mass="39509" checksum="B49C53D9147AE4D8" modified="2013-06-26" version="1">MSALRVPALKSWQLKYWAYLTGLPTTGTKAELKALLTPALAQHKHEPPSVRLASLDMGIRNLAFCVVEPQSPGRKSDKIQIKVNAWKRMDLLESATAESAENDALGEPTNDRQSPKRTRSKASLPVPKDSFTPAALSKAAYRVTKDLLSYAPNTILIERQRFRSGGAAAIQEWTVRVNMLESMLWASLHTLQQEARGATFPSVHAISPARVAQFWSSTASLSLAPTSLFDENNSDVQAMTTHSMSDRKKIEKKDKVGIVRSWIGGTPDLDLQFDGDAAKIADAFRLSTRQSKDAKELAGGKLDDLADCLLQAVTWLKWRENRRVLDKMWQKAVDDMALGDLDRDESLDSARRPSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQU6</accession>
    <name>N1PQU6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF300-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_71499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQU6"/>
    <dbReference type="STRING" id="675120.N1PQU6"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012923_5_1_1"/>
    <dbReference type="OMA" id="HAIYFQV"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME45821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="61464" checksum="0276389E8E36E897" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQX7</accession>
    <name>N1PQX7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_71470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQX7"/>
    <dbReference type="STRING" id="675120.N1PQX7"/>
    <dbReference type="eggNOG" id="KOG1304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009646_3_2_1"/>
    <dbReference type="OMA" id="WIRNISK"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF332">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="197"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME45792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="593" mass="64477" checksum="8BB812D72AFCBD77" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQY1</accession>
    <name>N1PQY1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_23831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQY1"/>
    <dbReference type="STRING" id="675120.N1PQY1"/>
    <dbReference type="eggNOG" id="ENOG502R15W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_780801_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108974" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="38223" checksum="EF049CCEB3FC3BDD" modified="2013-06-26" version="1">MTKFTLTVVTALSLAQACFALEARGADKTSAYTRHGGKYNPNVKTYYSDVYTPCTKTETVQTTTTEIVNEKHKLTTTVTTTQTIRAYEPSTYTVPASAGFIPVRSSLPDPGAPKDASAQDKRSAAPVSGLARRDYNAMNPGQYPQRVDVYHYKEKKQCITQTKTVTETQKACKTPVQFTVTSTATCKVTVYPSTTTVYAACQTNNMLPSYRGANIREVQVIDSARPDDEGFGLVRSDATDATACCVAAITMSPPSFVWTFNSGSVKPDAGRCAILTDDTCKAVPRTDSATIEATVYSDARPATDEAVLTVGNSYCGQWNRGCYDDAKGVRTCVSKGDANTISQDVPVNDPALVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRT3</accession>
    <name>N1PRT3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRT3"/>
    <dbReference type="eggNOG" id="ENOG502SARD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096567_3_0_1"/>
    <dbReference type="OMA" id="CIRFLQF"/>
    <dbReference type="OrthoDB" id="5363290at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18936" checksum="3198195B80AE8F8C" modified="2013-06-26" version="1">MAITDTLRSRASDSHGGLLGGILNGLLRFLQFVLALTVCGLYGVDLHHASQAPHGHADSKWVFAEVVAGLAAFTVITYASLSCCVPTWSEKLFGWDWIMFILWTALFGLFGSIYIDAHPSPEQHGQQRMKHAVWVDLVNMLLWLISAIYATLMFWKGRHNRSVHTGRAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRX0</accession>
    <name>N1PRX0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_52475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PRX0"/>
    <dbReference type="eggNOG" id="ENOG502SGAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005461_1_0_1"/>
    <dbReference type="OMA" id="GVAHARY"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1627" mass="168700" checksum="5B9825872D07881D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRX6</accession>
    <name>N1PRX6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="15">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">dhh1</name>
        <name evidence="19" type="ORF">DOTSEDRAFT_70202</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.</text>
    </comment>
    <comment type="function">
        <text evidence="15">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of pre-60S ribosomal complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="15"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRX6"/>
    <dbReference type="STRING" id="675120.N1PRX6"/>
    <dbReference type="eggNOG" id="KOG0345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_4_1"/>
    <dbReference type="OMA" id="AYKEHEC"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="45"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="292"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="555"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="569"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EME46122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="641" mass="72374" checksum="B8ED150E61FA833D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS03</accession>
    <name>N1PS03_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_22257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS03"/>
    <dbReference type="HOGENOM" id="CLU_773926_0_0_1"/>
    <dbReference type="OMA" id="SEARVEW"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="358" mass="39714" checksum="4825D09D103DE898" modified="2013-06-26" version="1">MDQAHQSLAWVTTFAHSPRIRTWIKGVQQARSTEVDDTAPRRGSDVSETASEARVEWERARAAATLEGRMSFDDERRAVWEQSPSYPFATKDRLTVRSSYATANTRARSTSKVPIVSAPLGWNYSSTSPIHPPHVGMDDRPDAWLGEPPTFPTKPSSARLRSSSADSGWTLTPSSYAHRSSWLQIIESGPYVHRTDAPPITRLYADPVATVKDHLAMGITSVEFISKPAQIQRPLEAHCCPEKIEGFEKDAEVLYGQNRPRTQQIPMEVKALRQKELGWYSELPPPTSSGESLFPPVYGTPIQGDSEKGSIGVVRRKEEGVEEGTAKRFVLSRNFWLGVMALLLLGLVCVYVPLAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSM7</accession>
    <name>N1PSM7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_22062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSM7"/>
    <dbReference type="HOGENOM" id="CLU_1348895_0_0_1"/>
    <dbReference type="OrthoDB" id="10631778at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="203" mass="23026" checksum="AA7D4AAA7AEF9446" modified="2013-06-26" version="1">MSATNIGQAHSAAPSVCTTENDPPQTQSQEQIGLSPNVPPFFRLPRELRDGIYNFAYGPDAPEVIKITSLLAKMDEAASNDLPKCPLSDMLVCRQFFLEVPATYFRMRTMKLCHLCMTVSDQIFDCFQGRLRFVHDFIDLDFTTISGVHDVPRLGKVELVSKATNKYTLAKTDEEIAQWHKNVAALQAFLKREIDRLWEDEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTF4</accession>
    <name>N1PTF4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_70611</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PTF4"/>
    <dbReference type="eggNOG" id="KOG0391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_24_2_1"/>
    <dbReference type="OMA" id="KLFAQWC"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="891"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="1445"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="552"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="774"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1647"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1715"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="559"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="714"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1680"/>
            <end position="1689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME46652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1734" mass="193789" checksum="E7AE217E7F10D4AE" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU76</accession>
    <name>N1PU76_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_168104</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU76"/>
    <dbReference type="STRING" id="675120.N1PU76"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_1_1"/>
    <dbReference type="OMA" id="PIVQGGH"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109093" description="beta-glucosidase" evidence="14">
        <location>
            <begin position="27"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="15">
        <location>
            <begin position="687"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME45910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="764" mass="83090" checksum="F6E2F202963CDA8C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUD8</accession>
    <name>N1PUD8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_32676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUD8"/>
    <dbReference type="HOGENOM" id="CLU_1758761_0_0_1"/>
    <dbReference type="OMA" id="RRRPNLH"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="148" mass="17029" checksum="9DDD97CA2C793B28" modified="2013-06-26" version="1">MAPQRRRPNLHLDLSDLTRPQYSLQRVSQEHELPQYRADDRPRDELGQTYYDASAEISSLEVGSPDVGSTNRGSYYVGTHDRHVSWTVELPKTVVHQASPRTSNWIITKIMSPFRKGNEVVTPQSVAPSPVLPERRYFTLKRRSRART</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUE9</accession>
    <name>N1PUE9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sld7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_145442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUE9"/>
    <dbReference type="STRING" id="675120.N1PUE9"/>
    <dbReference type="eggNOG" id="ENOG502S7PV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029042_1_0_1"/>
    <dbReference type="OMA" id="MTCIDEL"/>
    <dbReference type="OrthoDB" id="4205424at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041260">
        <property type="entry name" value="Sld7_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18596">
        <property type="entry name" value="Sld7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld7 C-terminal" evidence="2">
        <location>
            <begin position="289"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="453" mass="48906" checksum="9C11C4AAAB4F3AF7" modified="2013-06-26" version="1">MTAQWHGNLALGNDASLTGKTSQVPLCMNVGKPCAVTSSSAETEQWFSAILLGQHQDEAIDWWKSAIADSPLGILAAVKNTTIEDASPRTTELVFYAAKGASVADGPFSPPHSAPGDQAVAGDTIRLYALPLSSDLFDSAVRSEPTPPPTPRHSPEESDAVFLPLVEKRDLAAAETVNRPPVRKRKSVNETFDEAAERRRKARRKGGESVAAAAADQTEITLQDLKHRRSVSSAQVHLQIRPLSRSSSIVSVKPVIGRESSIPTATKASALCQVHSASAVGSPEKASIESKNKEFISRLVMAGMRLHGLYQSKRRRSRANSTMASPALDTSFEEIDAERQNDEEFKLMYHQIYRGTCFALRTSMAAVSLHTSTDAVRDTVDKLLAIFCSDPLTVAPSEHADDYTPGGRKVFGSSALHESKFDNPFVNAALAEATSTTNTPCSRRPKDEIRGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUR7</accession>
    <name>N1PUR7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_41681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUR7"/>
    <dbReference type="STRING" id="675120.N1PUR7"/>
    <dbReference type="eggNOG" id="KOG1754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_1_1_1"/>
    <dbReference type="OMA" id="LPAKNFG"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME47226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14879" checksum="EB1D2B32DCF16574" modified="2013-06-26" version="1">MVKTSVLNDALNAINNAEKTGKRQVLIRPSSKVIVKFLQVMQRHGYIGEFEEVDDHRNGKIVIQLNGRLNKTGVISPRYNVQLRDMEKWVVKLLPSRQFGYIVLTTSAGIMDHEEARRKHVAGKIIGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVR0</accession>
    <name>N1PVR0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_42957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVR0"/>
    <dbReference type="STRING" id="675120.N1PVR0"/>
    <dbReference type="eggNOG" id="ENOG502SA83">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046578_1_0_1"/>
    <dbReference type="OMA" id="TGLMKQY"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="60"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME46445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="318" mass="34943" checksum="1365CB077330B9A4" modified="2013-06-26" version="1">MDNIRNSQTAQSLANGPVAEKARNEADATKNEFGNLAAARQTPQTQTATGQDLTHYHSFFYSLLSWDNPRATAISYAVIVAFVFTTRYVPITRYALRVLYITLGVTAALEIAGKVVLGEGLASKLRPRKYYTIPHENLESLLSDVEELSNFFVIEFQRIVFAENVYATVAAFLTAFLGYFLVKIMPAWGLVLLSTTVIYFAPLAYLSNKEFIDHHINNASTIITEQTSQLREVAAQQTNNAVSSTSSLLKDYTGKAQEAIGQTKQAAVEKNIISSETAQKITPQKSAHDAEFPSPPKEEPSGPELAQAEEKTAEPIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW63</accession>
    <name>N1PW63_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_69631</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW63"/>
    <dbReference type="STRING" id="675120.N1PW63"/>
    <dbReference type="eggNOG" id="KOG3271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102600_1_0_1"/>
    <dbReference type="OMA" id="KDDVRMP"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="89"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME47751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="164" mass="17878" checksum="5B1922A1B80E55B4" modified="2013-06-26" version="1">MADNNDAQHEHTFESADAGASTTFPMQCSALRKNGHVVIKGRPCKIVEMSTSKTGKHGHAKVHMVAIDIFTGKKMEDLSPSTHNMDVPNVSRREYQLLDITDDGFLSLMSDDGSTKDDVKVPDGEAGDKINKLFREEEKDTNVIVLTAMGEEACIDAKEAPKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWP3</accession>
    <name>N1PWP3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_42159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWP3"/>
    <dbReference type="HOGENOM" id="CLU_2346657_0_0_1"/>
    <dbReference type="OrthoDB" id="10667217at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="97" mass="10854" checksum="B127CE439257C10B" modified="2013-06-26" version="1">MDPTRKLINVERHLAAAKACVAQLGVRIADKERSSGFADSGREGADSDVPAPCDLVEWPRHFKRLECIPEVMDPKTPQSDGSILWHTLTVCQRIQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWP4</accession>
    <name>N1PWP4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_87128</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWP4"/>
    <dbReference type="STRING" id="675120.N1PWP4"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_0_1"/>
    <dbReference type="OMA" id="YLSWKWV"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME46609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="511" mass="54620" checksum="85A51087FCD40D5A" modified="2013-06-26" version="1">MLQWFSFSDGLGSVRYGGAIQPTPTRSSQLPLSKARTISLVIVLTGAAFLNTLSVQACVIILPTIGTALNIPSARLQWVVSAYSLTFGCFLLLWGRLADVYGKRMIFIYGSAWFCIVTLVCPFIPNEIGFEIFRGLQGLGAAANVPTAIGILGVTFQPGKAKNYAFAMYSAGAPMGSVIGNMLGGVVGQYATWKAVFWVLAGLAAVITIAGHLIIPVQQVAPKELVVKNAVDWPGGILVTVGLVVLLFSLTDGNVVGWRQPYIPVLIVLSVLLVAVFVCWQIYLENRTSRRPLMKVSIFKNMRVSAAMATMALFFAAFNNFLIFATYFYQDYQGHDAIHTTVRFIPTGVVGVMTIFVSSQILARINVNYILMFGTSLFAVPIAPHTTYWAYGFPAMCLSVFGADTLFPALLLLTAHSLPREDQAIGGALINAVGQIGRAIGLAIATAIQVAVQESKEGSSTAATETKALGNGSFLTGLRSAERFSFAMGIVAFTIATACFGKVGKVGASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWR0</accession>
    <name>N1PWR0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_69694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWR0"/>
    <dbReference type="eggNOG" id="ENOG502SC3P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085138_1_0_1"/>
    <dbReference type="OMA" id="DWEDTNR"/>
    <dbReference type="OrthoDB" id="5304887at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053278">
        <property type="entry name" value="Pre-60S_factor_ECM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022784">
        <property type="entry name" value="Ribosome_bgen_Alb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280:SF1">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09135">
        <property type="entry name" value="Alb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME47852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="197" mass="21549" checksum="84434525DD59899C" modified="2013-06-26" version="1">MAKTPKVKKREISVHSRAARRSSPPPKDIAGKRAPTEESDYKPWMHNAQNAGVSKQARPKKLTHAQRLRQERAQEKALAIANKLEKKVADSKKSSKNIQSRAADWDELNGKLEAVAEAKKKEGKRASGKDGADVVLPNLEQLLPVRSAEMSGAEEEEVQREPVPASVSASAHALKEEGVPAWASMHAEPEEFLVAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWT2</accession>
    <name>N1PWT2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ARS binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWT2"/>
    <dbReference type="STRING" id="675120.N1PWT2"/>
    <dbReference type="eggNOG" id="ENOG502QV85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009887_0_0_1"/>
    <dbReference type="OMA" id="GHPHPYY"/>
    <dbReference type="OrthoDB" id="2104370at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018562">
        <property type="entry name" value="ARS-binding_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42048">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42048:SF1">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09441">
        <property type="entry name" value="Abp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="763" mass="84418" checksum="8357016237FEC72F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXF3</accession>
    <name>N1PXF3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXF3"/>
    <dbReference type="eggNOG" id="ENOG502R932">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1137978_0_0_1"/>
    <dbReference type="OMA" id="KYDEWEA"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="244" mass="28663" checksum="50FB0C912FADD866" modified="2013-06-26" version="1">MPDRTAGYQTSAAMDTSSFAKLSGELRNRIYEYALREGNEEQEPIDLEQGWFDCPFHRCRVMNEARTGFVHPLDPLRVTGLPFASRSIRRESLRLYYHLNSFYFETDYLKSKHKDRIMERLMEWVQRIGVEQAREIRDVTISLSSLKGSSTIPLVINWNHMKMIRSVFSSQGRVKIRFYLDGNGSAAFVLGPKEDMLAQLDRMAEGWAMLWRKSRKYDEWEAWTVAERYKQEVAELLKDMPETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXY5</accession>
    <name>N1PXY5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_69261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXY5"/>
    <dbReference type="STRING" id="675120.N1PXY5"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066033_0_0_1"/>
    <dbReference type="OMA" id="KMAIYGA"/>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME47255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28782" checksum="3775AB15C190DD3F" modified="2013-06-26" version="1">MSQVKFEQKETIRTTSGSGGRGGPPGGKEDFAHKIGDALTKGSGPDGYLAWYLKKLQEDPLRTKMITSGTLAGLQEFLASWIAKDRSKHGHYFTSRVPKMAVYGAFISAPLGHVMISILQRLFAGRTSLRAKIMQIIVSNLIISPIQNAVYLTSMAIIAGARTFHQIRATVRAGFMPVMKVSWVTSPLALAFAQAFLPNEVWVPFFNAVGFIIGTYINAHTKKKRLQALRRKYQDSSRTNDGRDGRDGRSEYGGSRPGPGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY11</accession>
    <name>N1PY11_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_67461</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY11"/>
    <dbReference type="STRING" id="675120.N1PY11"/>
    <dbReference type="eggNOG" id="KOG0015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063931_1_0_1"/>
    <dbReference type="OMA" id="GGHYPQD"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME48416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="215" mass="23978" checksum="E4D95F761D25813B" modified="2013-06-26" version="1">MSAELVNQDPTNDHEQEELENGNESRGVKRQRTSNAADDDDDDDDKPGRERRKIEIKFIQDKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVSETGLVYTFTTPKLQPLVTKPEGKNLIQACLNAPEPADSNGVDGDGSAVESPEEQHTAPPPMPPNMPPQGMPRNQQPQQPYMTADQQQALQYQAYLQQQQAAQQGAYPMAPQQHMQSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZF4</accession>
    <name>N1PZF4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_67755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZF4"/>
    <dbReference type="STRING" id="675120.N1PZF4"/>
    <dbReference type="eggNOG" id="ENOG502QTKQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007124_0_0_1"/>
    <dbReference type="OMA" id="TNVGFEC"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15485">
        <property type="entry name" value="ZIP_Cat8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000007">
        <property type="entry name" value="C6 transcription factor FacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF12">
        <property type="entry name" value="REGULATORY PROTEIN CAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="608"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="691"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME48807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="918" mass="100167" checksum="267A25E55E8F8F18" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZN4</accession>
    <name>N1PZN4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_67490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZN4"/>
    <dbReference type="eggNOG" id="ENOG502SBBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1611818_0_0_1"/>
    <dbReference type="OMA" id="IKCFANV"/>
    <dbReference type="OrthoDB" id="5399555at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="157" mass="17341" checksum="D9FE22B86FFEBBAB" modified="2013-06-26" version="1">MTRNDARFSTYSGAPSLQPSLAPTLDTNSNRSSTNQYLNSRLSEQTFLTPQTIPENSGRTVYGNHAAASSSLTLSSTDPKTAEIKCFANVLDRMSDERADKQRFVMNANKTEEHSKIALGAKVERALSRRMVGQDAVFRTKVKSPIDEKRALEVEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZU3</accession>
    <name>N1PZU3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_40277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZU3"/>
    <dbReference type="STRING" id="675120.N1PZU3"/>
    <dbReference type="eggNOG" id="ENOG502S44P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102617_1_0_1"/>
    <dbReference type="OMA" id="NKGVFQG"/>
    <dbReference type="OrthoDB" id="5358886at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002590">
        <property type="entry name" value="HSP9/HSP12_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="112" mass="11368" checksum="A59AF6E27423F61C" modified="2013-06-26" version="1">MSDSLRQSNTDKAASALKPDSQKSTLEQVQDSAKSTADSVAGTLQPEGEKSIGQKASDTVTGSGGDASKEGETYLKQAQDGAANLANQASETISAGVKQAQDALGLNNQGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0J2</accession>
    <name>N1Q0J2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_69809</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0J2"/>
    <dbReference type="STRING" id="675120.N1Q0J2"/>
    <dbReference type="eggNOG" id="KOG4075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070101_2_0_1"/>
    <dbReference type="OMA" id="YVIHLFA"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME47994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="180" mass="20011" checksum="00EDA2ECDC6F6C43" modified="2013-06-26" version="1">MLRAATRLPATVQTTRSAAAALTPLSRKQQSPQQVRCAHAISNPTLANIEKRWEAMPPQEQADLWMALRDRMKVDWNELTLQEKKAAYWIAFGPHGPRALPPPGEGTKIFMYTILGVVAAGAIFGATRYFAKGTPRTMNKEWQEATNEYLKENKIEPITWVGNPDYKGPGAVQSPPAPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0X9</accession>
    <name>N1Q0X9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_49691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0X9"/>
    <dbReference type="HOGENOM" id="CLU_1242699_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME49426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="223" mass="25147" checksum="B5C0261048CE15C0" modified="2013-06-26" version="1" fragment="single">MIPHYYYHYSYYYYTTTYSSAQTPPPACRASSNTTIVHVLSPPTCTRTCTCTRTCTRACTRHLQSGTWHLAPYRFPHEHRTARSLLLLAADHHALARGPTSSGQRLQSALLCSALLNMIRYVVHTQQVDTWCTLWPPARQHCRTSAAHPSLLINNVVVVPRARGPCNYPPHARHTAVQLFELLLKLVASLLLSRCVRALQAFTSPNCVVSPCKFPRGEADRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1K5</accession>
    <name>N1Q1K5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate pyruvate transaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamic--alanine transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamic--pyruvic transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_118712</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1K5"/>
    <dbReference type="STRING" id="675120.N1Q1K5"/>
    <dbReference type="eggNOG" id="KOG0258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014254_3_0_1"/>
    <dbReference type="OMA" id="FGFECPP"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000010">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="107"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME49123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="497" mass="55162" checksum="8F031940B7C63C6A" modified="2013-06-26" version="1">MQKREFSQSSSSKSLNINNINPHIKEAKYAVRGELAIKSEQYRAQLAKGEGKDLPFDSVISANIGNPQQLDQKPITFFRQVVSLVENPQLLEHEDVLKNGLGYKSDVIERARSLLKDVKSVGAYSQSQGAPGIRQSVADFINRRDGFPADPQSIYLCGGASAGVNALMSVICASPKTGILVPIPQYPLYTATLSLLNAQVVPYYLKEEDQWSTDVADMRSALKEAQKKGIDVRAVVVINPGNPTGGSLEAQHIQSVIELAAEEKLVVLADEVYQTNVFEGKFQSFKKILRQLQDGDKNKDGKFDSVELASLHSISKGMVGECGHRGGYYEMIGFDPEVVAQIYKFVSIMLCPPVVGQCLVELMVNPPKEGEPSYAQYQKEYDTIFDNLKARAHALYDAFQEMEGVECQYPQGSMYLYPTIKLPRKAIDAAKKEDKNPDDYYCLRLLDATGICIVPGSGFGQREGTLHFRTTFLAPGTEWVSRISEFHKAFMHQFSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q221</accession>
    <name>N1Q221_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_143988</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q221"/>
    <dbReference type="STRING" id="675120.N1Q221"/>
    <dbReference type="eggNOG" id="ENOG502S6DH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047453_0_0_1"/>
    <dbReference type="OMA" id="CLQSWRH"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="55"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="307" mass="33927" checksum="0E21DE19208B19F7" modified="2013-06-26" version="1">MAACTTGSSWSFDNLPGSFQSSAASTNSHTAANKPTASNDTASPAPEGPQPKRRRTHYPPRKCRICLEEVHPTFSDAPEPALPASMQSAPRATYESEDGGRLLSPCKCKGTQKYVHEECLGAWRRADPTQKRNYWECPTCRYRYNIQRLTWSAWISSTTAQIGLTLLIFVVSTFVLGFFADPIINLYLAPVDTIVSGGIVPTIEPTTWAEHMAKGFASLGLLGFAKYFLSSPFQWFRFGGGNRYGRNTAGSGRDRLQQISWITLAIGISTIAYAVWKGVRAWSRRKLQQAGERVMDVPGAEDDDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q229</accession>
    <name>N1Q229_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_119214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q229"/>
    <dbReference type="STRING" id="675120.N1Q229"/>
    <dbReference type="eggNOG" id="ENOG502SBMP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162852_1_1_1"/>
    <dbReference type="OMA" id="AMTMDHR"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME49816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="80" mass="8783" checksum="A249E57827372B1B" modified="2013-06-26" version="1">MPLVVPGLQSNDGGKTAEWMNKLAGKKIGETSNETTFAKTDLPQQHRILKGDSMMTLDHNPDRLNIHTDDDGTVKKVTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2G6</accession>
    <name>N1Q2G6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_67785</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2G6"/>
    <dbReference type="STRING" id="675120.N1Q2G6"/>
    <dbReference type="eggNOG" id="KOG1152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004134_0_0_1"/>
    <dbReference type="OMA" id="MDESECR"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14004">
        <property type="entry name" value="STKc_PASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000320">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057213">
        <property type="entry name" value="DUF7891"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25421">
        <property type="entry name" value="DUF7891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="944"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="336"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="476"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="849"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1203"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="891"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME48840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1231" mass="135758" checksum="9F5CCF297DD901AB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2J4</accession>
    <name>N1Q2J4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_67813</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2J4"/>
    <dbReference type="STRING" id="675120.N1Q2J4"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OMA" id="EMEWHAR"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="454"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME48870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="611" mass="68611" checksum="9A46AF164D12CA2F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2X6</accession>
    <name>N1Q2X6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_67783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2X6"/>
    <dbReference type="STRING" id="675120.N1Q2X6"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_274183_0_0_1"/>
    <dbReference type="OMA" id="PLHFSGE"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053210">
        <property type="entry name" value="ANKRD12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149:SF14">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="413"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="629"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="822"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="770"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="822"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1120" mass="125064" checksum="6104A8BCC1715508" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q313</accession>
    <name>N1Q313_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_121327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q313"/>
    <dbReference type="STRING" id="675120.N1Q313"/>
    <dbReference type="eggNOG" id="ENOG502S8RU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086132_1_0_1"/>
    <dbReference type="OMA" id="YPEWLWR"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME50146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="220" mass="24347" checksum="4ED9F78DB0F1A355" modified="2013-06-26" version="1">MICRKCAQRLARRDASIVTSRTFAQTTSQRAQAVTAQTTTATNPRPNDRPAATSTSAAQPFSTPLTPSPDSLNLPINKDVDKSKQPLKIQSSVPAGTILKGLNFMKNKQDPVALEDSEYPPWLWTVLNKSGAAESGQGQDAEGDLFSKSKKQRRIAAKALKRKQLLDPESLAEKVPIYEQSIDLPSDPKEGLQAREQLTKAMRVRRRSKIKEDNFLKEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4B8</accession>
    <name>N1Q4B8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_49701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4B8"/>
    <dbReference type="STRING" id="675120.N1Q4B8"/>
    <dbReference type="eggNOG" id="ENOG502S01X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006240_0_0_1"/>
    <dbReference type="OMA" id="IYEQLGW"/>
    <dbReference type="OrthoDB" id="5395343at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042511">
        <property type="entry name" value="Sld3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="2">
        <location>
            <begin position="242"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="872" mass="97279" checksum="29BF62A22B207D1D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4J5</accession>
    <name>N1Q4J5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_143977</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4J5"/>
    <dbReference type="STRING" id="675120.N1Q4J5"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_1_1_1"/>
    <dbReference type="OMA" id="RDWYWWR"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000001">
        <property type="entry name" value="Maltase A3, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000007">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF232">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 13 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="6">
        <location>
            <begin position="20"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="596" mass="68891" checksum="DD35D7CF9CECD2AF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4U2</accession>
    <name>N1Q4U2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_144320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4U2"/>
    <dbReference type="STRING" id="675120.N1Q4U2"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042179_3_0_1"/>
    <dbReference type="OMA" id="SPWCSLT"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="114"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="359" mass="39830" checksum="FB282533DB620BCF" modified="2013-06-26" version="1">MADRTEATLLDKLLFAPVLAKVLISTLFRAITLPLTSLTGAAKANKPMKDILFAALRTQLSSINAAQEQWTLTTTTEKNYLEFAGKEKLQPQSTVLNSGLRLHWLGPKTSDKVIVFFHGGGYVLPMSDGHFKWLLNLQVELSEKTSTSVIIVGYTLAPYGQFPKQLQQAAETLAWLIGKQKRRPRDIIIAGDSAGGNMALSLISHVIHPHPDAVKIDLNEPLAATVLISPWSRFDADYDSWKRNAKSDMLPPEATYRWSSLFLGSKPANSYSEAWRADEQWWSGLDKVTSDLLVWGGSAEVLIDSINEVGKQLKVAHPKTEIVIQKGASHEDFIIDVLLGYKHKAEGSKVIESWLSERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4Z2</accession>
    <name>N1Q4Z2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_68592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4Z2"/>
    <dbReference type="STRING" id="675120.N1Q4Z2"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046304_0_0_1"/>
    <dbReference type="OMA" id="KMDNMRL"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF4">
        <property type="entry name" value="S-ADENOSYL-METHIONINE-STEROL-C-METHYLTRANSFERAS (AFU_ORTHOLOGUE AFUA_4G09190)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="139"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME49849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="411" mass="45265" checksum="7272AABCA7214113" modified="2013-06-26" version="1">MEAQESEVGAAPHSLEIGRKSRGKKRSRRVRTILRSFQTLRNLTPEQVDNFMNSYIIYDLDWADEESMIAALGPNYQHAVGQCLADYYSVLNHLCAIGEVEKMYIPPVLDLDASILDNQSLYEESITKELLLPANAKVLDLGCGRGLVAAHISRVTGAQITGLNIDADQIASANTHNKQLGLANTFIRADFNELPLPLPDNHFDGFYQIQAFSLAKDHEKLCQELYRVLKPGARVSLLDWARLDAYDPTNTHHQELMKRIKPLIGAVGTPTPASLQHALEAAGFHMLLSNNASIDGIQAPLIERADGYFCVAKRTVLGLVRLGLLPQHFKTLFNRLTQDCEAFVEADRARLITTSHHWLAVKPRTADSTATSEKAVPITTAASSDTAVNSQTESIVDGGRLPSEATVKFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q552</accession>
    <name>N1Q552_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL18 C-terminal eukaryotes domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_31141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q552"/>
    <dbReference type="STRING" id="675120.N1Q552"/>
    <dbReference type="eggNOG" id="KOG0875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056222_1_0_1"/>
    <dbReference type="OMA" id="CQIASAH"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="239"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME50014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="302" mass="34633" checksum="50C9B2B5A16E5129" modified="2013-06-26" version="1">MPFTKLVKNSAYFSRYQTKYKRRQAGKTDYYARKRLVTQAKNKYNAPKYRLVVRFTNKDIIAQIITSELTGDKVFVAAYAHELKRYGITHGLTNWAAAYCVGLLIARRALSKLDLADTFEGVEEPDGEFGLTEPAEVDGEERRPFKCFLDVGLVRTSTGARVFGALKGASDGGVYIPHSEKRFPGYDMESKELDAETLRKYIFGGHVAEYMETLADDDEERYKSQFQGYIDDEIEADGLEELYADAHKQIREDPFKKDEEEGEKKSKDEWKAESKKFRQVKLTHAERKQRVQEKIKALASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2WI56</accession>
    <name>M2WI56_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_75444</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WI56"/>
    <dbReference type="STRING" id="675120.M2WI56"/>
    <dbReference type="eggNOG" id="KOG0812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044998_0_1_1"/>
    <dbReference type="OMA" id="EHNHNVV"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090083">
        <property type="term" value="P:regulation of inclusion body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000007">
        <property type="entry name" value="ER-golgi SNARE complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="257"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME38693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="349" mass="38356" checksum="02A5416BF8E2E005" modified="2013-05-01" version="1">MSALTMTSHASIQDRTPEFRSILAQAQKSLARQRKAGGAQAQLLLPQSNGQAIPPTRKQRSDFARNAAGIGRGISATMGKLQRLGELAKRKTLFDDRPVEIAELTYVIKQDLAGLNQQIGQLQQMQRQTNQGKQVDQEGEHNKNVVVLLQGRLADVSVNFKEVLEVRTKNIQASRSRQDNFVSSVSQQSHLGDGPGRTDSPLYATPQRGPSPKPPQSNGADVLSLDPTSDRSALYSGSGGQASQQQLQLMEEGSSSNTYIQQRGEAIEAIERTISELGGIFGQLAQMVSEQAEQIQRIDANTDDVVDNVEGAQRELMKYWSRVQGNRWLVAKMFGVLMIFFLLWVLIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2WKE7</accession>
    <name>M2WKE7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_179990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WKE7"/>
    <dbReference type="eggNOG" id="ENOG502T3Q3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_398019_0_0_1"/>
    <dbReference type="OMA" id="MACYLED"/>
    <dbReference type="OrthoDB" id="5244622at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="662"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="690"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="728" mass="80710" checksum="1EF00CD4A84871DB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2WNF7</accession>
    <name>M2WNF7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_25475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WNF7"/>
    <dbReference type="STRING" id="675120.M2WNF7"/>
    <dbReference type="HOGENOM" id="CLU_313987_0_0_1"/>
    <dbReference type="OMA" id="PPNVPPM"/>
    <dbReference type="OrthoDB" id="3650171at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004028050" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="720"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="932" mass="91845" checksum="634E0F80D04F0789" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2WNT4</accession>
    <name>M2WNT4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_80971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.M2WNT4"/>
    <dbReference type="eggNOG" id="KOG3548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_243269_0_0_1"/>
    <dbReference type="OMA" id="YLDTILW"/>
    <dbReference type="OrthoDB" id="129353at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17724">
        <property type="entry name" value="BRCT_p53bp1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047250">
        <property type="entry name" value="BRCT_p53bp1-like_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="1325"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="476"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="870"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1002"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1074"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1211"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1258"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1372"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1587"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="615"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="793"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1002"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1084"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1262"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1276"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1590"/>
            <end position="1601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME43673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1628" mass="177970" checksum="77C414DE4890AD66" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2XGH7</accession>
    <name>M2XGH7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_83973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XGH7"/>
    <dbReference type="STRING" id="675120.M2XGH7"/>
    <dbReference type="eggNOG" id="ENOG502SUNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535253_0_0_1"/>
    <dbReference type="OMA" id="LMHYNRD"/>
    <dbReference type="OrthoDB" id="412402at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="517" mass="58260" checksum="DAFE886F981C3237" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2XHY7</accession>
    <name>M2XHY7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_75686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XHY7"/>
    <dbReference type="STRING" id="675120.M2XHY7"/>
    <dbReference type="eggNOG" id="KOG1450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010730_3_0_1"/>
    <dbReference type="OMA" id="DSGWQAR"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07652">
        <property type="entry name" value="F-BAR_Rgd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000063">
        <property type="entry name" value="Rho GTPase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF136">
        <property type="entry name" value="RHO GTPASE ACTIVATOR (RGD1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="50"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="524"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME39082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="77717" checksum="D00C7F8F36361B78" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKL0</accession>
    <name>M2XKL0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_53963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKL0"/>
    <dbReference type="STRING" id="675120.M2XKL0"/>
    <dbReference type="eggNOG" id="KOG3321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051208_2_1_1"/>
    <dbReference type="OMA" id="MRAAYFL"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="8">
        <location>
            <begin position="83"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME43032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="264" mass="29292" checksum="90BF12B8E6E96ED7" modified="2013-05-01" version="1">MSTPPCTRSLVGAVKRLKLSPATPAVQHQIRHIQKSSRDAASSSSQLSSADANANIRLPKAVQATYLAPLKRALSAEPTKVADLQLRSYSVRNLEVFADFAMRAAYFLKLPAAGPTPLRKITERWTVPRSNFVHKKSQENFERITLRRWIQVFDGHPDTVAVWLAFLRKHQYYGVGMKAEVYEHGTLTTGKDLEEEAEKVRKLMGEGESFASFGDLNRSGDNLAKKLWDSPFKRSWGADAAMGGTPGAGTGKERLSVPGDLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2XLG2</accession>
    <name>M2XLG2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XLG2"/>
    <dbReference type="HOGENOM" id="CLU_2413241_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="92" mass="10382" checksum="CB0D62AD56E31650" modified="2013-05-01" version="1">MLTGIGRKPQPLEHSNHQPLTPTNKHRSFPGIIKHRRPKEMLLDSINRSVVPLTFFQDTPIVDLDPLLEFAVVELQDDLYQPVGCSGSLLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y1C1</accession>
    <name>M2Y1C1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiol-specific monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_56601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y1C1"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_3_1"/>
    <dbReference type="OMA" id="LYQHVVW"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME39104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="54874" checksum="EF7F027E5781B149" modified="2013-05-01" version="1">MVSIPVKRVAVVGAGPAGTISIDALMKEQAFDLVRVFERCSGPGGCWAADDGPPPTISDFRELAQRNADAPLPIPQTLPTMTPKSDQPRFAESTVYPYLETNVVAEAMEFSQEPFPSQVSQMSQSLYGPTSPFRHWSAVQGYIKDLVKRNGYEDTITYNTTVEKAEKIGPVWQLTLRKGGKEHDYWWQEDFDALIVASGHYNVPYIPAVGGLDATERNRPGSVIHSKQYRGRNAYRGKRVIVVGVSVSAADIAFDLVNVARTPVHAVVINHTPNAYFGAEAFNHPNIQRHPSLVRVDSRAAYFEDGTCVNDVDHIIFGTGYTWTLPYLPQVPTRSNRVPDLYQHVVWQHDPNLLFVGAVNAGLTFKIFEWQAVYAARLLAGRGTLPPLEEMRRWELERVKLRGDGPKFTLVYPDFEDYFETLRKLAGEGKPGVGRKLPRFRREWFRAFMDGHELRKQMWKRLNQEARKLQEAESSPESKTSGARARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y1M2</accession>
    <name>M2Y1M2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_28378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y1M2"/>
    <dbReference type="HOGENOM" id="CLU_1578494_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="169" mass="18968" checksum="A221BF0B8EF36D7B" modified="2013-05-01" version="1">MTTLQEVRIGVLIALCIYFRVPASTGTAVAVRHRLALVVPSDKIVTTTVDVSSCKDSGLASHIQVWEADIQRPTGSFRPVHMQVLAAELCTYLEFSVGPTTTEYHQEVAIIDLDDALRDNRKAVITAFNDLPYKFSTFFVMGKWFKMRTIELMLTLTHKEGPRPLRTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y4B6</accession>
    <name>M2Y4B6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_132686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y4B6"/>
    <dbReference type="STRING" id="675120.M2Y4B6"/>
    <dbReference type="eggNOG" id="ENOG502QU1D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008335_0_0_1"/>
    <dbReference type="OMA" id="MLLYSMM"/>
    <dbReference type="OrthoDB" id="5426798at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME43134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="790" mass="88168" checksum="2BCE977EAAF7510E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y4D3</accession>
    <name>M2Y4D3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_54046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y4D3"/>
    <dbReference type="eggNOG" id="ENOG502TM2S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1250656_0_0_1"/>
    <dbReference type="OMA" id="TIRCEMP"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="221" mass="25507" checksum="435B550F43F05E61" modified="2013-05-01" version="1">MENSKLGKLPAELRNLIYEFALRSPADVQIRREPGILWTCKQIRAEAEQMFYAVNDFFGIEHEDHESHGLCCEWLKTKASYLHLIRSLTIRCEMPSLGRKVPQIDPTQVEEMDDEVAFRGFYHQLHIMDELREAQFGRDVGNVVRFTLNGAHDVESFDQIDAMSTEDQDRYRSAKFLIFFLVYGLDTTMDNAEASTADKLLRGMDDAIQQQRLLADSRAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y5R8</accession>
    <name>M2Y5R8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_25517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y5R8"/>
    <dbReference type="HOGENOM" id="CLU_1272276_0_0_1"/>
    <dbReference type="OMA" id="MVECINR"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="217" mass="24002" checksum="2226A65153434684" modified="2013-05-01" version="1">MATNHKDEKDFADIELGAQEPTNTQVHHDSTGHAHAPSRRTSDSEFYNKDYTTSYEVSYTPSSRHIECHPDPPISTTYTSPAPSTNPQRPSTLSKILTRLSIYTWLLPKSAHLLTTILALPGFFSLFHAFQHKILTTGICGPSISADLSDSALLWIVYAVLWLVLMEIEVINRAFPASGKGGYKKEAMRVCAGPFAVGMWIVVAAVVEKKVESHCQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y628</accession>
    <name>M2Y628_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_35913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y628"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070111_0_0_1"/>
    <dbReference type="OMA" id="KAWITIL"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF10">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="64"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="328" mass="34816" checksum="A1DE056B1AAB5CCC" modified="2013-05-01" version="1">MGTQTLTVDAPALELDDLQSRSQNDLNIELAPKANEEEKTLASTGPSVVTVEPPKLSTRKAWITILQLCGNAFINSFGAGVLIVCLPVISTDLDLPRNLLLWPTSVTSLASASCQLIAGSVADVLGPKTPNSVGSFLQSVLIIATGFAADAYQLIIFRALLGVASSIFTTSARAILSRNIERGRLRNFAFAAIVLSFPLGAGLGLVLGGIYAEKSSWRIAYWSSGAVGLLLSISGVFTLPSGPGKHVSWSEVRRRLATEIDWVGAIIASTALALLSYVFALLSASTEYIHRPVNAVLLATSLALIPAFAMWMQRREKKGLPALIPNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2YII4</accession>
    <name>M2YII4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_75464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YII4"/>
    <dbReference type="STRING" id="675120.M2YII4"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078272_0_0_1"/>
    <dbReference type="OMA" id="ISAWEME"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306:SF7">
        <property type="entry name" value="AHBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME38721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34720" checksum="585B2B0B62C1D856" modified="2013-05-01" version="1">MAGAPKWLPSLAPAAQARARVISAVVEHHDALHRLQEGGSPDRRWGDMNDCSTVMVDRTKAWFAAKSPPKAYGGGDGAVFWAMNVNANQVIFWLVWYAYSQPGLLQELRDEVAPCVKPGVSTDGAAHIDMDSLWKYCPLLKGAFFETMRIEAASMSYKQAEQDFVVRESLDDAKLLGRSEPQSFEIEKGEYICIPHVVHQSDGRYFRDPDRFNPRRFWVHDANTAGNAGKQNNVTVDYKTMKVWGGGKQLCKGKTFAEREVVLFAAAVISAWEMEPVNGQWEHPGRVPTAGTHVPKKDVRVRMWKREGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIZ3</accession>
    <name>M2YIZ3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_92189</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIZ3"/>
    <dbReference type="STRING" id="675120.M2YIZ3"/>
    <dbReference type="eggNOG" id="ENOG502RGY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_5_2_1"/>
    <dbReference type="OMA" id="EVDGPYF"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="119"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME38905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="578" mass="64260" checksum="A28F2B615E6B4596" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKF2</accession>
    <name>M2YKF2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Notchless protein homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome biogenesis factor RSA4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_56755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NLE1/RSA4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKF2"/>
    <dbReference type="STRING" id="675120.M2YKF2"/>
    <dbReference type="eggNOG" id="KOG0271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_16_1"/>
    <dbReference type="OMA" id="AWEPYHR"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110136">
        <property type="term" value="P:protein-RNA complex remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000092">
        <property type="entry name" value="notchless protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="137"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="223"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="271"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="395"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="437"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME39335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="512" mass="55958" checksum="2155A880466FF71C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKR9</accession>
    <name>M2YKR9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_75212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKR9"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032067_2_0_1"/>
    <dbReference type="OMA" id="AWWGDIR"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000228">
        <property type="entry name" value="FAD-containing monooxygenase EthA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME39465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="496" mass="55882" checksum="0868A0FC069BE019" modified="2013-05-01" version="1">MAWQPMEKGGDNFDVVIVGAGISGINFGYRLQERCPNLSYTILEGRHELGGTWSLFKYPGIRSDSDLFTFGFSWRPWSEKTSIAQGDLIKQYLKDSAASAGIDKHIQFNTKVSSTDYNSNDKTWTLQAVQNGSEKKSIKCRFMLMCTGYYDYEKPLAASIPGLDNFKGEVIHPQFWPEALDYSGKDVVIIGSGATAITVLPVMAETAKKVTMLQRSPSYVMAVPQEDAFEKVVRKVFWWFPAAQHALIRIKWIMMPLLLTSYSARYPKKMQQLMYKLTQKQLPASIPRDPHFTPKYYPWEQRMCMCPDGDFYEALRKGVATIETGVIQEVTSNAIKLESGKELNPDIIVTATGLKLQFAGGMQVSIDGKPYDCSEKFVWKGVMLEDMPNAAFVVGYVDASWTLGADATAQTITRMLNQMKREAVVEVTPHLSEDEVKNMKEKSLLRLNSTYVTKGNSVLPKAGDRGQWQPRANYLRDILMAWYGDVKTGTTWVRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLN0</accession>
    <name>M2YLN0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homoserine kinase</fullName>
            <ecNumber evidence="4">2.7.1.39</ecNumber>
            <ecNumber evidence="5">6.3.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DOTSEDRAFT_72369</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Commits homoserine to the threonine biosynthesis pathway by catalyzing its O-phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4"/>
    <dbReference type="EC" id="6.3.3.1" evidence="5"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLN0"/>
    <dbReference type="STRING" id="675120.M2YLN0"/>
    <dbReference type="eggNOG" id="KOG0237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021258_0_0_1"/>
    <dbReference type="OMA" id="CLMEERH"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000068">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000007">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="10" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="20">
        <location>
            <begin position="67"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="23">
        <location>
            <begin position="263"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like N-terminal" evidence="21">
        <location>
            <begin position="420"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="22">
        <location>
            <begin position="539"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EME42906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="718" mass="76940" checksum="904DEB612DA1595B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLX2</accession>
    <name>M2YLX2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_173382</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLX2"/>
    <dbReference type="STRING" id="675120.M2YLX2"/>
    <dbReference type="eggNOG" id="KOG3055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065050_0_0_1"/>
    <dbReference type="OMA" id="IEWNKTH"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME42885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="259" mass="28081" checksum="7BAE73285F9B9F95" modified="2013-05-01" version="1">MTRFRPCIDLHAGSVKQIVGGTLSTDNAGLKTNYTSEHPAAYYAELYRKNDLKGGHVIMLGPGNNEAAKEALAAWPGGLQVGGGIKDTNAEEWIDAGAERVIITSFLFPSGTFSLERLQSVLNALGGDRQKLVIDLSCRRVEGGWSVAMDKWQTITNFEINKDNIAVLEPYCSEFLIHAADAEGLQAGIDETLVSYLSKICTIPVTYAGGGRNIQDLELVDRLSSGRVDLTIGSALDIFGGKTVTFEECCEWNSRCEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2YM75</accession>
    <name>M2YM75_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_53942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YM75"/>
    <dbReference type="STRING" id="675120.M2YM75"/>
    <dbReference type="eggNOG" id="ENOG502S36W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075131_0_0_1"/>
    <dbReference type="OMA" id="YILPRMP"/>
    <dbReference type="OrthoDB" id="5366541at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.70">
        <property type="entry name" value="Get5 dimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049256">
        <property type="entry name" value="Get5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024737">
        <property type="entry name" value="Get5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047154">
        <property type="entry name" value="UBL4A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17183">
        <property type="entry name" value="Get5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12754">
        <property type="entry name" value="Get5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="64"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME43005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="237" mass="25898" checksum="4C53FBFACB0B5C5A" modified="2013-05-01" version="1">MSEVTFAKQFLATIDKKPIKLPADHVSDPRQYPNQSPYILPRQTHPFPRRSGPTSSQQASSKTITATLKPMRNGETITLPSIALDTTIHDLKTQYASKTSIPQDKIKVLYNKKPVADLKTLKDIGIEGDAELSLMIMGGGGGTPRAQSPAVTAEKERVPVPDMKADSMDVDEKTSAPESEKATAEAEEKKEAQGAAAILKTDEFWADLGGFLSQRLRDDEVAARLLTVFKSASKQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2YME0</accession>
    <name>M2YME0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YME0"/>
    <dbReference type="HOGENOM" id="CLU_1315389_0_0_1"/>
    <dbReference type="OrthoDB" id="10503915at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="209" mass="23108" checksum="DB71CFBD8F2ECF0E" modified="2013-05-01" version="1">MGGQAPHPLMVEGLSDVAPEPTHGLPPYGSGGVQKYGVRDHYSKHPYNLGMLGRACHTPYQQRPGYTAYIRGLIESPVAELLSPVSDYVSLHHGATGTQAYRTITAQPAHQSKSQDELRLKHYREQQQEQAKQDTETGSIRSDATDDQGTTWVRTRQFATSIFSESTSTAASRNSFGRFSIDMGQRGPLVNIEDRSNSDREIASLMEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2YNF8</accession>
    <name>M2YNF8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_45427</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YNF8"/>
    <dbReference type="STRING" id="675120.M2YNF8"/>
    <dbReference type="eggNOG" id="KOG4077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099086_0_0_1"/>
    <dbReference type="OMA" id="MEKWPAD"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME43530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="162" mass="18368" checksum="8AB8D0A4FCFF64CD" modified="2013-05-01" version="1">MSSAVLARVSRARFFAARPARSFIVSPVFKPTTTTAALFSSASRRLAASPADDPHDPHHEESFEEFTARYEKEFEQVQDVFELQRNLNNAFAYDLVPSPSVITAALRAARRVNDYPTAVRIFEGIKAKVENKNQYEEYLKELQGVREELGVHLKENMYPEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2YPW8</accession>
    <name>M2YPW8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transaldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YPW8"/>
    <dbReference type="STRING" id="675120.M2YPW8"/>
    <dbReference type="eggNOG" id="KOG2772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047470_1_1_1"/>
    <dbReference type="OMA" id="PIKPHDQ"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF39">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40229" checksum="62B0C0C7513F2FE7" modified="2013-05-01" version="1">MPHPTSQTWLEKLEEQLNVDVDWMDPTYSKNLSITPNDMTSNNLWVNQQMSHPENKAMFERVCKELKAQGWKAAYTRIAVLMCKNNLDNIKGRVLLQVYPNEAYNTQSVLDSARAYAKEFERAGISQDRYCIKIPSTGPALNACPILKKEGIRTLGTALFSVPQAIAASQAECLYISPYFNEVKAHDDHALWPDVEDPATQHTMAARTLRILETYAKLYKQTGKEQPLLKQASFITAKEAMAAGEHGCHSATISPQVLDELAGLQYDSSKQPGEGKPKPDHPYVEYRTPDRLREVSKVDPLSKGKADAGTEVDYLANNGAELQKAIEADPVTTQRLKDALELFTGGLLESKAKIEAQFQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC08</accession>
    <name>N1PC08_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC08"/>
    <dbReference type="STRING" id="675120.N1PC08"/>
    <dbReference type="eggNOG" id="ENOG502S5P0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039192_1_0_1"/>
    <dbReference type="OMA" id="QIGVRNY"/>
    <dbReference type="OrthoDB" id="5397087at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="434" mass="47380" checksum="E82D2A0CA0A0F262" modified="2013-06-26" version="1">MPPVRTMPVTRPVRTERTHEENQERAYIAASRRSDRSLEARVESARRASEIHKKRTGRSLRVREEDVMNEEMYEEEDDDLPMQFRRINALNPGFAFNNFNDRVNSYLAGQIGVRNYLHQAIYQANQANQMNQQFYNPMMQQGFNGTMSPQAMSGPFNGMQQSPFQQTSSMQNMRPASHGRSASIATPQEFAHYQQPQAAKATTPVSTDGRRVSVHSAGAPSPSASHAKSTAGSQPPTPSADLQKSTSAKRAPTPPHTAAHLPQGLRPSAASPASGSTSFEQSMYPLTTKLPLETQQLMDVPQFAGYASHMAPGMAPGSYSYNPNGKKRDSSHNSPSGIHGLDQTLTQFPMGSQGAMSNTTHAEPQSALSAPANLDFGFGSDMYGDMSHFNDSTYAFDLGFGSGSNTSHNSGHVTPATEQNWNESDFFNYAAASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCC4</accession>
    <name>N1PCC4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_38110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCC4"/>
    <dbReference type="HOGENOM" id="CLU_2108944_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="115" mass="13184" checksum="CFED011CDDC266A4" modified="2013-06-26" version="1">MALIIVNRCDDLERSDLTLLEGHAKIKEWSKWKWKVLMKDLETPRSDHTLIDCLRPPYDSPVPEARVSIHVQRRKHITTPRATGDLGVSIVVSGRRAPDMNAWLRMPEPPAILRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCL7</accession>
    <name>N1PCL7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_107919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCL7"/>
    <dbReference type="HOGENOM" id="CLU_203576_0_0_1"/>
    <dbReference type="OrthoDB" id="3645438at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7828" checksum="9825F872423C9065" modified="2013-06-26" version="1" fragment="single">CALLELPAELRANIYRFALCEETKIANGQDSFQQPAILWTCRQVRQEASTNRYVENRFLLPTHNFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCR0</accession>
    <name>N1PCR0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="10">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_47375</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="10"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCR0"/>
    <dbReference type="STRING" id="675120.N1PCR0"/>
    <dbReference type="MEROPS" id="C19.A61"/>
    <dbReference type="eggNOG" id="KOG1867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_11_2_1"/>
    <dbReference type="OMA" id="NVSCNCI"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF33">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="141"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="415"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME39824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="513" mass="57837" checksum="3E12E343EEED3ACD" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCT4</accession>
    <name>N1PCT4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate esterase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCT4"/>
    <dbReference type="STRING" id="675120.N1PCT4"/>
    <dbReference type="eggNOG" id="ENOG502QQRF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1396280_0_0_1"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="195" mass="22404" checksum="77F2A85C7587A696" modified="2013-06-26" version="1">MLIAYQFQWGIRQGLPRLIKLFRQYNWKWTTWTCARAFETSPTYARILADEGHEIACHGNRWRIHGSNLAEAKAHIHKSFDRLQATTGLIDVPTGWFAGGMPNHTKLARAEVHRERGVPLLYCSDTYAADVPYWIQDPYAAVHGGPDQGMLMIPYSLCTNDHRCMLGCARLRPSRHRLLTGMCSLRCPRPWRLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD25</accession>
    <name>N1PD25_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_56306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD25"/>
    <dbReference type="STRING" id="675120.N1PD25"/>
    <dbReference type="eggNOG" id="KOG3854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012966_3_2_1"/>
    <dbReference type="OMA" id="IWQCADE"/>
    <dbReference type="OrthoDB" id="20772at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035240">
        <property type="entry name" value="SprT_Zn_ribbon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17283">
        <property type="entry name" value="Zn_ribbon_SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="365"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="627" mass="69593" checksum="66A6CB58AC059F09" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDH4</accession>
    <name>N1PDH4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDH4"/>
    <dbReference type="eggNOG" id="ENOG502SB08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115686_1_0_1"/>
    <dbReference type="OMA" id="GQGNIGH"/>
    <dbReference type="OrthoDB" id="2537432at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="136" mass="14240" checksum="A7E713AF9506CADD" modified="2013-06-26" version="1">MANPIHSTGRGGAGNIGPDGHVYVDGDIIREGTPGVSKEPDYSAGRGGAGNIAHADRVGVPSHEVVPESATRTDQQAGANYDNYHTGRGGEGNVHKEKYGGHSQPQKEHGKESLLDKAKHAVGLDKKEKTPEPSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDK3</accession>
    <name>N1PDK3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_74277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDK3"/>
    <dbReference type="STRING" id="675120.N1PDK3"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_1_1"/>
    <dbReference type="OMA" id="RTKRTCI"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04132">
        <property type="entry name" value="Rho4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000678">
        <property type="entry name" value="Rho GTPase Rho4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME40673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="268" mass="29712" checksum="D1F07FD2BB6E38F1" modified="2013-06-26" version="1">MSVTAVNPRFDDLKRKNSSKSFLTRGDSHRRSTRGSDGTVNTTSSARTNITAPPEYSKKFVVVGDGGCGKTCLLISYSQGYFPEKYVPTVFENYITTVEHKRSGKGVELALWDTAGQEEYDRLRPLSYPETDLLFVCFAIDCPNSLENVLDKWFPEVLHFCPTTPIILCGLKSDLRHKRTCIELLKTQGLTPVTQQQGKQVAQKMGAMYMECSSKEMAGVHEIFDTAIDIAVRGQDSLAEEGSSAPGSRGGQLNLPVKRKTRSKCKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEE9</accession>
    <name>N1PEE9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_115668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEE9"/>
    <dbReference type="STRING" id="675120.N1PEE9"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_7_0_1"/>
    <dbReference type="OMA" id="HYISSAE"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="192" mass="20892" checksum="02B9A1586A4186CB" modified="2013-06-26" version="1" fragment="single">KPSRRMDLVVMQRKVKESLIKGVTAYIVERSNKRYVSLGIPHRRGYLLCGPPDCGKSSVINAIAGDFNLSVFSICLSSSELTDDLLKGLVRSLPECALVLLEAVDASGLESRTISSNNSKHNTKSSQSRAKTGITLFGLLNCIDGANAVEHRTLCMTTSTSNTLDPALVHSGRIDMKVLFANANHDVMRQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEX4</accession>
    <name>N1PEX4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_82423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEX4"/>
    <dbReference type="STRING" id="675120.N1PEX4"/>
    <dbReference type="HOGENOM" id="CLU_1069675_0_0_1"/>
    <dbReference type="OrthoDB" id="3637282at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="260" mass="28467" checksum="B53F47B7BAA3BADA" modified="2013-06-26" version="1">MNVHASAILTRRASVFDFPQSGITSELGRRGILVTSARASLLDILQQDLSGFESRFTKRPSSETLRVYHSKWHSARISLSRRHALHCAPYWSATPHSFVYELVLGFSKGASVVDQGLRYLDAATVRNKALDGDANNTVIQQLSAVRSLSGQTQVKISISKHGGRAPCGCAVLPVSAAAHVYLELNENLASPEKRAENCDVKLKAAKAEHDHMVQTKTELGAVQHNEVTEAALLAEKREKDDVARTRALEDCNNVLRSMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF32</accession>
    <name>N1PF32_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF32"/>
    <dbReference type="STRING" id="675120.N1PF32"/>
    <dbReference type="eggNOG" id="ENOG502SSJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813866_0_0_1"/>
    <dbReference type="OMA" id="AHIISIY"/>
    <dbReference type="OrthoDB" id="2997776at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="39292" checksum="DBE6A3DAF1F9BB6A" modified="2013-06-26" version="1">MMDMLPNELLQHIFSFAALDRKHTASLWTSARQVSKPWRVNMAKVYLDLFILTPGRCNIFCGRYDAIVMRISKVLMLELFFDRLEGTDNDRCVFKEDPKSTGRPSKGASEDFKRSYESKKGRLWKRALDQYLGIEEGKAVRRMRYEHPAHIISIYGHSLDSPLPGLEYDIEKRELSFQWEPMFTAFFLEQHELGRLSEGLESYSELADRFAAEQLRPYSGHLRIALMAKRLRQAAANKEKIMTKVRRQRIVKQYQRQHREKGFEFEHDSEIEWKDEPVYVGKIVAANGAGTGRDRTHVPSTHSGSNDEDDEGNNLIEGTALPDSDSSSSGGYEHHDLSDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF56</accession>
    <name>N1PF56_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_47443</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF56"/>
    <dbReference type="STRING" id="675120.N1PF56"/>
    <dbReference type="eggNOG" id="KOG3504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169255_2_0_1"/>
    <dbReference type="OMA" id="PRTNKYP"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME39946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="65" mass="7455" checksum="8ED48040698B94AA" modified="2013-06-26" version="1">MAKSKNSSQHNQSKKAHRNGIKKPKTHRYPSLKGTDPKFRRNHRHALHGTMKALKEVKEGKRDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFD5</accession>
    <name>N1PFD5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_74927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFD5"/>
    <dbReference type="STRING" id="675120.N1PFD5"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OMA" id="PPWVSTH"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME40285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="530" mass="60097" checksum="BF9109B21FB8BD3C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFY7</accession>
    <name>N1PFY7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_27612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFY7"/>
    <dbReference type="STRING" id="675120.N1PFY7"/>
    <dbReference type="HOGENOM" id="CLU_057752_1_0_1"/>
    <dbReference type="OMA" id="IEFCYTF"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="29"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="261" mass="29244" checksum="8664286F764F00BE" modified="2013-06-26" version="1">MAAKHFDLNEARAAANQNLTKLRRDDAFCDLTVECGNTSIKAHRVILAARLRLVLESMRWWEGKAPCVTLEGDDGEDVASMIEFCYTFSYAEATAKDCGPLTKAVRMFALGDKYLISTLQTFAVDAFIHHLETSWDEQDFFEAVKLVYTGLSDPQRLLHNTIVETLRARYTSNSTWSTAFNDLLDITPGLAADAFRAIAQQPITTSTLGHKLKLYKCPAHPCPATFLSIIGEDEAHLWRCPYCHLISSLTGKGWELYIISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGB1</accession>
    <name>N1PGB1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_36603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGB1"/>
    <dbReference type="HOGENOM" id="CLU_1517827_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="177" mass="19956" checksum="927DE79D49B265D9" modified="2013-06-26" version="1">MASPILLKTQMEQTISTWHEIWTLLESLIGTPNAVPNGLKDNFLDATETILTLAVAYQDYDFDYAKLRAQLVAGSFRESWAASLFKDRGQRSKRMLDACRLAEKFLKGREESEVEARLDAFKMVLKNFEQSPALVAFMEQAGKERDKADGTVMAGGIENRTEDIKKRRSKETKSGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGN3</accession>
    <name>N1PGN3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGN3"/>
    <dbReference type="STRING" id="675120.N1PGN3"/>
    <dbReference type="HOGENOM" id="CLU_595841_0_0_1"/>
    <dbReference type="OrthoDB" id="5332281at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="459" mass="50353" checksum="7CA169C87BD474EC" modified="2013-06-26" version="1">MKLAALAVEITCDIFDSDAFETIVTYDADDDAPGLVFAHICGTDECKEKVQDTTTGYSLATQRTNKTLLTVRAANWGQFAGNPYGNSDSRFYGFAANMFSSPEVQVLIADFASISGPVANFLYVPGNGSSIEVHSPNMFNVSLPTIRAVSCTPALQNVEVQATLERKVQAGLDGKVTLLSWAVTDFDTSSIRVTSELNITDIQVLRKLLPRGSTWGHSPSLNPDYSPVKSNFTNKSQLDDDDIRPSAGIASNFFELLAAYESSQGRNSSALLDVRELGAATSAVYGLHNAELLSHFRATSSLSTRATFDERQAQMDTQEARVRPNARTTFAVVGMLCVIWVLLSIIFMTTTSSNVLLSKPGMISTQLSLFAGSEIVERLRGNNPDAVWDEKLSLGWWRPGEREVGDATLRWGIDIGRLDDSLQTTAIPRKTDARRCSLASLTFWRRRPVRGVRQSMETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHQ7</accession>
    <name>N1PHQ7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_117821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHQ7"/>
    <dbReference type="STRING" id="675120.N1PHQ7"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060397_2_0_1"/>
    <dbReference type="OMA" id="GAMHWSG"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="45"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="208" mass="22875" checksum="A31F754EEF7DA8A1" modified="2013-06-26" version="1" fragment="single">KDLVRTGYDAVAPAYLDFITRLPSPGITWVDKLLKLLPNACTSKVLELACGNGLPCTQHLAPKVGHITANDISAAQIHLVKERLAARHNISYISGDMSQLSFVDGTFDTVLALHSLIHLPRDEQPAMLRLAHKWLRPGGILLCNFDEEADVGTVIEDWLGTRMYKSGFGVAESEKMIVEAGFVVLEAEVVREVEGKKTVPFLWVLATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHS6</accession>
    <name>N1PHS6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_27473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHS6"/>
    <dbReference type="STRING" id="675120.N1PHS6"/>
    <dbReference type="eggNOG" id="ENOG502S8WA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1229907_0_0_1"/>
    <dbReference type="OrthoDB" id="4941332at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="225" mass="24825" checksum="74A60B387B0E5B33" modified="2013-06-26" version="1">MTDDLQHGYHPVALDLKVAYLWSSGILSEGPAGLRRKPSEYALRRYGPTYRWRLWLFFDIGELEAMERMINSGSDEDVFAFRRLHLASGATTTVVGSLLASVCATMLSLDSLSEVNLTVRGLFTVSLMLALLAVYFALIQQRALALSMDADSLRIWLWNGRKYGILNPVDGTEVSIRESSLSANMVLEAPFELLSISITLFLGALAAYLGLAMIQEVNLGTGSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHT5</accession>
    <name>N1PHT5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_26812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHT5"/>
    <dbReference type="STRING" id="675120.N1PHT5"/>
    <dbReference type="eggNOG" id="ENOG502SDW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122989_0_1_1"/>
    <dbReference type="OMA" id="GHVQKFT"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="132" mass="14724" checksum="5F2546D82FE811DE" modified="2013-06-26" version="1">MLRQSMRASRQTLARAVFRQNAVTTRRTFITPTAVRQADLVQDMYLKELKAYKPQPLKANDAEGHVQKFAVPKAPQSPEEADLQNDLSAYEQQTPEVEGHSGAPGSSQPVQDWFDESIFEEEEPSNPAGASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIC2</accession>
    <name>N1PIC2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIC2"/>
    <dbReference type="HOGENOM" id="CLU_2757758_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="70" mass="7909" checksum="A338310EC5DE6DD1" modified="2013-06-26" version="1">MTLEYWHVHIGLDFGKNMVIMRLDTYSQATPGGLRNVAFERGDKTVHSFRLIDVSGDSADMGDCDFDFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIW2</accession>
    <name>N1PIW2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2-16 kDa</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ubc1</name>
        <name evidence="13" type="ORF">DOTSEDRAFT_72980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIW2"/>
    <dbReference type="STRING" id="675120.N1PIW2"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="OMA" id="VHFTTRI"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME42064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="147" mass="16496" checksum="3DF4E7CC4F36D95C" modified="2013-06-26" version="1">MALKRINKELTDLGRDPPSSCSAGPIGDDLFHWQATIMGPGDSPYSGGVFFLAIHFPTDYPFKPPKVNFTTRIYHPNINSNGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIAHVYKTDRSRYEATAREWTRKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ52</accession>
    <name>N1PJ52_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="15">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_73691</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Endoplasmic reticulum membrane</location>
            <topology evidence="2 15">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Microsome membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the SFH5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ52"/>
    <dbReference type="STRING" id="675120.N1PJ52"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045138_0_1_1"/>
    <dbReference type="OMA" id="MVQIHDY"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0492">Microsome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="17">
        <location>
            <begin position="140"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME41356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="340" mass="37583" checksum="FA8378502941C82E" modified="2013-06-26" version="1">MAVDWSDLPKEHKLAQFAAGLSSILETAGYNEMYGVELIAPSTDTPAPHTTLIILQKYLRANVDDLEKAKEQLTAALKWRKEYQPLRAKDEVFDGDKFASIGYVTKVKGAKETPNEEDVACFNIYGNAAKDSKKVFGDTEAFIRWRVAQQELAISQLNLSSADKSIPEYGTGPDPYKMIAVHDYLSVSFFRQPAEIKASSQKIIDMFQRYYPETVSYKYFVNVPTVMQWMMGAMKMLMSKDSIQTMTWMTYGNQLCHYLGPDIPKEYGGTGAPLVETAITPNYGVHEKQAAKPAEAVTETAPPAQTDSIPTAQVVAAQQGPPAGTIPEVIGQPEDKSTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJB6</accession>
    <name>N1PJB6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_26595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJB6"/>
    <dbReference type="HOGENOM" id="CLU_1547551_0_0_1"/>
    <dbReference type="OMA" id="ITASTYR"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="173" mass="19641" checksum="9287B3CA59258373" modified="2013-06-26" version="1">MPVVDDENEAPSMTPHAKLAADIAAADEQQRQTFASTLRSLASHTVFERGKRGHIFSTTRNQIISLSIAITASTYRNLPEGWKDQQEVLKSGLDLASKTRLPVDNRVYQRQLKDIERVSWSQYSQEQSEENVQGYVEKELVRLADEKRRRSAKWKAKGRSGLLEKIVEGQEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJQ7</accession>
    <name>N1PJQ7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Nuclear transport factor 2</fullName>
            <shortName evidence="4">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_73992</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJQ7"/>
    <dbReference type="STRING" id="675120.N1PJQ7"/>
    <dbReference type="eggNOG" id="KOG2104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131642_0_0_1"/>
    <dbReference type="OMA" id="QFVEYYY"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME41775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="126" mass="14193" checksum="B2A35E344F00606C" modified="2013-06-26" version="1">MADFENVAKQFVEYYYKQFDSDRSGLAPLYRDNSMLTFEATPCQGAPAIVQKLQELPFQKVEHQVATLDAQPSNESGGILVIVSGALLVEEEKRPMSYAQTFQLLPTPEGSYYIFNDVFRLVYPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK32</accession>
    <name>N1PK32_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_53141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK32"/>
    <dbReference type="STRING" id="675120.N1PK32"/>
    <dbReference type="eggNOG" id="ENOG502RV5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821756_0_0_1"/>
    <dbReference type="OMA" id="QEWIERS"/>
    <dbReference type="OrthoDB" id="5365739at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="374" mass="40308" checksum="50D87AC7A303BB1E" modified="2013-06-26" version="1">MFSKRALSSLSSSERQLLRSQWLHSGQCARCFHASMRHRAGNASRSGDGNNSPAIAEQAAPPDSINPPRPQPSRKERSARISNEVSMLQKGPPPSGDTTGPGSLTGAYHAPPQAPTKSAGFLETPDDLVADSPRVGDNVSEGREGPNAQGVGRPVRYEDRRNGLQDTTLEARGVRGSGQVEEPAEGGASVLGGSNPESAHHQEWIERSGREQEDTQNAAPARTAQNIVQPRLNHTLSTTRLEKDLIHGPRTYTIAGTNTRAFLGSIRNRLGSTTFPSSPAAEPTKHRFNRLSQFAQQSLVNKLVAGQYDRENWLSGEKFAKNTTLKEVARKTTLNGTYLQMDAERLVKKVQSLLPSAASGAATGQRGQKKAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK60</accession>
    <name>N1PK60_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_176085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK60"/>
    <dbReference type="STRING" id="675120.N1PK60"/>
    <dbReference type="eggNOG" id="ENOG502QUCG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019062_0_0_1"/>
    <dbReference type="OMA" id="WLLQTLW"/>
    <dbReference type="OrthoDB" id="2922289at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF2">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="810" mass="93654" checksum="77440F279984CB0F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKI2</accession>
    <name>N1PKI2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_79908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKI2"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OMA" id="LTVNQYV"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="30"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME44007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="518" mass="56528" checksum="A87244240B3BDA92" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKV1</accession>
    <name>N1PKV1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_73113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKV1"/>
    <dbReference type="STRING" id="675120.N1PKV1"/>
    <dbReference type="eggNOG" id="ENOG502S3W3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086393_0_1_1"/>
    <dbReference type="OMA" id="RLFCETM"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME42180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="275" mass="30520" checksum="4FB8898DE269A48E" modified="2013-06-26" version="1">MPARPRPSLLVVPTPRQALMPSTPTSWLLRASISRPAGQGERGRGFEVPLGGLPSPPPSPDLGRTRPSLRARKRSGDAASHIMGECERLFCETLKTVFLVEKDTGLENSLMMDLRNNDNTSSTNGAKPIPQPSQRHTTFQHGQPTPLSSPDGRIYPKHGDMIKEYVEVWDYAGGARFRGFVAEKTERTMFIFFDKEVIGMDLKPGLMSLLELSTSDHFDCTQLVICVDRTACPSDVQDLNKSLGWVGFELSTLDDWSRSSTSCISDRYIFLGMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKW4</accession>
    <name>N1PKW4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_171959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKW4"/>
    <dbReference type="STRING" id="675120.N1PKW4"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027089_1_2_1"/>
    <dbReference type="OMA" id="VGFMNAV"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF60">
        <property type="entry name" value="FAMILY ZINC TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="51854" checksum="FC3AB13FBD97EC2A" modified="2013-06-26" version="1">MSGNGPYRSEMSARWDDLPTSLLYEELARRQADGERPACGSKHKSHSYNVTTHVLALFLILVLSTGACSFPLIVRRFPKLHIPEKALFISRHFGTGVLIATAFVHLFPTAYTNLLDPCLPPFWTDVYPAMPGFIAMTSVFVVVGIEMFFATKGAGHSHSVDFAQLRGDGELGTERVRSDPRRSMDSFNSFRQVPLGDERGHKDPQLRERRSLYQDSPAGPGSGSPSSSLNKPLPPDPEGDDSDLDLDELDPAADDDQAPLTRRTPSDDSKDEDDLVLANGHATGRPKSHNRQVSWADQQPSHEHSHSTERTPEEQRLVLQCLMLEAGILFHSVFIGLAVSVSTGSAFAVLLVAIAFHQTFEGLALGSRIASIGSFSLTSYKPWIMCLLYGVTTPIGQAIGLGVQGLYDPMSEFGLLMVGIMNAISSGLLLYAGLVQLLAEDFLSDTSYHELKGKRRLQACGAVVGGALLMAMVGAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM54</accession>
    <name>N1PM54_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM54"/>
    <dbReference type="STRING" id="675120.N1PM54"/>
    <dbReference type="eggNOG" id="ENOG502S7XT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054781_0_0_1"/>
    <dbReference type="OMA" id="AYLMPKA"/>
    <dbReference type="OrthoDB" id="2530523at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="180" mass="19193" checksum="4BC9EE3131EA7EAD" modified="2013-06-26" version="1">MVAPPLPQTPGSLPQGAVSPFPRSSLSPGSQSRDDERVALLFEINVELLQEVNRLQTEGHGGAISPQQLMQLRSEGKPDKMASEEYIQCLRRVQANLAWLMPRASTDSAGLAKAPPGPAHMTPPPHMVQLQSSYAQLTELFPGWKGLDRQSSQSAPSPGLHGPNPMATNGMTSAPAQAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN43</accession>
    <name>N1PN43_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_169860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN43"/>
    <dbReference type="STRING" id="675120.N1PN43"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057738_3_0_1"/>
    <dbReference type="OMA" id="TRTCFIH"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="35"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME44851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="284" mass="31866" checksum="F5A9B800E59997EF" modified="2013-06-26" version="1">MSKRKLRSDTALEGVVAEPIAIEDIIVKKAKKNVVRYLCSSCDVERTAGAFPDYNPSSECEHLINTCKDCLKAWVNVQIETAQFATGGENGKRFGVKCPECPAVMKNVNIQIATTKKMYASFEKAERKHIVDGTPGWRWCLAPNCDAGQLHESKAIHDPRLSKAKSRSKKKQIDPETNVEDICTCNECGARACVSCDRPYHEGEICAAYQDRVKDRTEEEDKSLRAIERITRKCPNCKKNIQKNGGCRAMQCAACNVDFCWTCLSQMDQGYCKCFPRPAQAQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN56</accession>
    <name>N1PN56_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_44187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN56"/>
    <dbReference type="HOGENOM" id="CLU_2209953_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="107" mass="12206" checksum="D548B1B0E508E123" modified="2013-06-26" version="1">MTNRAPADSYGRLLIKASGRAKTDRRPWTRIDSRMHQRPPDANNIDAGVLKVTTWSRTFVPTGTSRLATGSRPRTSMRRGTMQRATLEIVWREYSAVVRCCSSRLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP11</accession>
    <name>N1PP11_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_44452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP11"/>
    <dbReference type="STRING" id="675120.N1PP11"/>
    <dbReference type="eggNOG" id="KOG2751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024219_3_1_1"/>
    <dbReference type="OMA" id="EWDVYKA"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000005">
        <property type="entry name" value="Autophagy protein Apg6, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="4">
        <location>
            <begin position="165"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="3">
        <location>
            <begin position="296"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME44179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="499" mass="55421" checksum="23D55C16073122A4" modified="2013-06-26" version="1">MPPSNAATPGTSVLKCQKCKTSLQIDGSLGTLNPASFKILADAAPILEPKAPEAPRSAAAKDRRQLYNHVSQQAGPPMHKRNVTASLRAASGKQHPDMSYINISDSQVVSPSQHQAFISPARKKIVTRNSDPLNTANGETLMSQEMESVMRLFEILSARSDIDHPVCSECTELLLEGLQRRQAGVSRERDAYVDFLKEAQQDVPTDEEKSKTKRDLEDARQREKQALQELEALEVEKARMEEEIVILDAEAEELDEEEESFWRERNAFAAELAAFQEERDSLQNQLAHDNKVLEALQRTNVYNDTFCIGHDGTFGAINGLRLGRTQEISVDWPEINAAWGQTLLLLTVVIEKLGLRLKGYELVPIGSTSKVIRLEYPHTASTNDTKPKKTVFELFSSGDLPLGLGFLHRNFDNAMVAFLECLRQVGEHVERTTPKPGSPGLKMPYIIAKDKIGDVSIKLGSFGQEEQWTKACKYTLTCCKFLLAHASHVADAADTKPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP98</accession>
    <name>N1PP98_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Catalase</fullName>
            <ecNumber evidence="13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_43598</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="13"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP98"/>
    <dbReference type="STRING" id="675120.N1PP98"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_1_1"/>
    <dbReference type="OMA" id="FYNQGAR"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF62">
        <property type="entry name" value="CATALASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="36"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME45212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="566" mass="63835" checksum="60326E5D34D14B52" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPI6</accession>
    <name>N1PPI6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_71996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPI6"/>
    <dbReference type="STRING" id="675120.N1PPI6"/>
    <dbReference type="eggNOG" id="ENOG502QQW9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028296_1_0_1"/>
    <dbReference type="OMA" id="ISRYCYW"/>
    <dbReference type="OrthoDB" id="164921at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019431">
        <property type="entry name" value="DUF2417"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10329">
        <property type="entry name" value="DUF2417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="63050" checksum="A499FBA3A10CF34A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPT0</accession>
    <name>N1PPT0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_79426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPT0"/>
    <dbReference type="STRING" id="675120.N1PPT0"/>
    <dbReference type="HOGENOM" id="CLU_1468132_0_0_1"/>
    <dbReference type="OrthoDB" id="3177213at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="184" mass="20220" checksum="8689278B648A4215" modified="2013-06-26" version="1">MSNIASLASAVLIFSHLHALFAWLNEYHFGSIRQRIWSFVHIPFPFALVLTTEGANQSIMWRAAMITAAAPFGTPVYEKQDSDAPGAAIAKTWDYTASSIIQESLQASKGLASKLDGLNARSFVGICVSEIRERTNLDSVHLNEDRLWSISNTAIFNTAGFGGQKKQTEAVWKPGKAITDQDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ30</accession>
    <name>N1PQ30_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_43453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ30"/>
    <dbReference type="HOGENOM" id="CLU_2440826_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="90" mass="9645" checksum="B93751C66296A2E0" modified="2013-06-26" version="1">MPPSCSHDRVDGLQVLRLSILSTCITKQTEGKTVRSISIRSTPRTLQIPSTFCKPSTDSIWTISKAGSIADATYSLGLDSPRSNAIQPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQA1</accession>
    <name>N1PQA1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_52815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQA1"/>
    <dbReference type="STRING" id="675120.N1PQA1"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002806_0_0_1"/>
    <dbReference type="OMA" id="EACEQYV"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF113">
        <property type="entry name" value="POLY(A) RNA POLYMERASE CID11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="114"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="335"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="442"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="545"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="742"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="903"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1003"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="799"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1039"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1063"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME45577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1085" mass="119243" checksum="E36E266DD02854CA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQW1</accession>
    <name>N1PQW1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_71511</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQW1"/>
    <dbReference type="STRING" id="675120.N1PQW1"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="OMA" id="GDEPYTF"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME45836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="197" mass="21922" checksum="2D45012798F13252" modified="2013-06-26" version="1">MVVATIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVHHHCPGVPCLIVGTQTDLRDDPSVRDKLQKQKMQPVRKEDGEKMAKDLGAVKYVECSALTQFKLKDVFDEAIVAALEPPTVKKPKRKGKGCILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRB1</accession>
    <name>N1PRB1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_127776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRB1"/>
    <dbReference type="STRING" id="675120.N1PRB1"/>
    <dbReference type="eggNOG" id="ENOG502S8KX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092849_1_0_1"/>
    <dbReference type="OMA" id="QWYGLQT"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213:SF2">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19625" checksum="9561FBBB56EFB98B" modified="2013-06-26" version="1">MASDKGELKIENTNIKTAPGVDLSERQKTLVGSVLDLFAGRPSLAKLQLWQDDGEFIDPLTIAKGRKQYEAQWYGLQTAFSEIERLSHEVKSNGNPIELDLKTRYVVKGIGKEQTIASKVLIHQDGDKISKVEDRWDGKLPESSIAQFFQRVNANTVPYIVGVPKNAEEDAKKGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRX5</accession>
    <name>N1PRX5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">IEC3 subunit of the Ino80 complex, chromatin re-modelling-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_70274</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRX5"/>
    <dbReference type="STRING" id="675120.N1PRX5"/>
    <dbReference type="eggNOG" id="ENOG502SG34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038623_0_0_1"/>
    <dbReference type="OMA" id="PVSVYNW"/>
    <dbReference type="OrthoDB" id="4095124at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055449">
        <property type="entry name" value="Iec3-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032742">
        <property type="entry name" value="Iec3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24244">
        <property type="entry name" value="Iec3-like_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14612">
        <property type="entry name" value="Ino80_Iec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit 3 N-terminal" evidence="3">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="INO80 complex subunit 3-like middle region" evidence="4">
        <location>
            <begin position="182"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME46221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="41782" checksum="6B49C0DE80DB03E1" modified="2013-06-26" version="1">MSDSEGVAAHPPPHPTTAGKSIGGPRPKYKSWRKKYRKMRHNFEGVLDENKKLFKEDQKMEGIARRLREELDDLRDLLLDINQNPALPASMRYNINLDKPNTDIASIRSVVDDNISPQEANETLAEYKSAVQRGQIPHMDLHVIRAQINQKLSAQDVDTLADIGSTTSHPFQPGPIMDQFVGSKPPGYYTTEEEDARLLRLDALLGDQLSLERKREKEQEGANEPLHWAEMTPREVERQVELQNPQSQHNWLKIHARGTGADADDTESLASHDPKPSAARGAKGKKRDLAQQVGDRAVGRARDGNSPGAASGAGDEEDYGFIDDHPQGSAKKRKAKDEDGAYRVKGGKSGGGNAKGKRKRATGDDGAVSGKKPKVDASVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS24</accession>
    <name>N1PS24_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_170503</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS24"/>
    <dbReference type="STRING" id="675120.N1PS24"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020880_3_1_1"/>
    <dbReference type="OMA" id="FPWVNAS"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000065">
        <property type="entry name" value="Similar to histidine acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF14">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109300" evidence="4">
        <location>
            <begin position="18"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="54"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="404"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME45224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="462" mass="51375" checksum="D57D694FC8E3CB02" modified="2013-06-26" version="1">MLPLLALPALSLASSQQQPLYSEYSFNPLEHLAGIAPYFEPSDPPREPNPPQGCEVTRVAYLVRHAAINANDFDYESYLEPFTDKLKNTTVDWSKIPDLSFLSRWSPPELKEQERVTRSGKLEASQLGVQMSFRYPKLRLPKRVWASTAERTVVSAEALIRGLETEENEIELVQIYEGKEAGANSLTPYSSCPAYSSSRGSSQSQAYAERYTAPILARLRAQAPGFNWTSDDVIGMQEWCGYDTVVRGSSPFCSLDLFSPDEWLQFEYTQDLMYHHNIGYGNPVSGAIGFPWLNATASLLASNNSDDQDIYVSFTHRELPPTVLVAMGLFNNSAMTGANDVNATMPTTQINYHRQWVSSYILPFLTNIAVEHMNCSASYGYQNATDPTYYRVLVNQSPQTLPGCYDGPLESCSAAGFAKFVQERGQEVGDFSSACGVKYDNSTDVMSFYTNSTLDGETVGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS36</accession>
    <name>N1PS36_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS36"/>
    <dbReference type="STRING" id="675120.N1PS36"/>
    <dbReference type="eggNOG" id="ENOG502QTFK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006822_0_0_1"/>
    <dbReference type="OMA" id="VHEDFFP"/>
    <dbReference type="OrthoDB" id="5418235at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF2">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="938"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1265" mass="139129" checksum="9429A42EC5A6F0A1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSS9</accession>
    <name>N1PSS9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7962 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_126826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSS9"/>
    <dbReference type="eggNOG" id="ENOG502S2Q4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039745_1_0_1"/>
    <dbReference type="OMA" id="IGNDVYC"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058268">
        <property type="entry name" value="DUF7962"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25907">
        <property type="entry name" value="DUF7962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7962" evidence="2">
        <location>
            <begin position="92"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="324" mass="36471" checksum="6EA9577D1FFAD83D" modified="2013-06-26" version="1">MMPRPALRDNFHLTYRKIPVLAFGRDVYCDTSLISEALEHFFPPSEGYQSIYPRARDGSNYRSMMRGFASYWVDRPYFRATCGLMPASIWRSSFGDDRAGLIGHKLNPDKLERKLPENLSKLDMHLSILEPMLAESEGPWLFSTATPSLADIALYYQTLWGTDIAAGRYIENITMGQTPDETNEGAASVFNQERYPGVLSWFQRMQHYFDELQSVEDQVTKLESVLEQMKQSPALGPKSLLLPTPRAAHAELDRKNGLHRDALVSVAPDDTGKDDPTIGTLVALSPEEVVIQPQALESPASVETRIHFPRLGFVVRPVKEKGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT13</accession>
    <name>N1PT13_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_168372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT13"/>
    <dbReference type="STRING" id="675120.N1PT13"/>
    <dbReference type="eggNOG" id="ENOG502SKB7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009555_1_0_1"/>
    <dbReference type="OMA" id="VMDVPIM"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="527" mass="58425" checksum="745E430CD1CBB107" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTB9</accession>
    <name>N1PTB9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DOTSEDRAFT_125874</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTB9"/>
    <dbReference type="STRING" id="675120.N1PTB9"/>
    <dbReference type="eggNOG" id="KOG2986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030279_0_0_1"/>
    <dbReference type="OMA" id="KQTVNWP"/>
    <dbReference type="OrthoDB" id="341477at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028840">
        <property type="entry name" value="Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="424"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EME46208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="471" mass="53419" checksum="86B3662AFD958762" modified="2013-06-26" version="1" fragment="single">PGWEERADYDIQKFSDLPHKYFGYNQHIKVNEDFKESLRQVLWQFRAPIRYAFAYGSGVFGQKSSTSSTGSEFSPHSNPPKAVEDWQKGGAKIIDFIFGVSHTQHWHSLNLQQYPEHYSGLRRLPYSSAVVSWMQDGWGAGLYYNPYITVNGIMIKYGVVNLDTLARDLTDWDTLYLAGRLQKPVKILRDDPRIRLSNQVNLVSALRTALLMLPERFSERQLYERITSLSYLGDPRMHSLVASEAPSKVSNIVGAQLPGFRQLYVPLIENLPNVGFTDSRTPRQPGWEKEDAIRHTGTITKLEDNVLGGEEGLSLSQDLDPVKRGNMVRRLPKAFRKKLYYHYKGKFQIPGSAFDNILEETKDDDPQGFKRREGGDFERRISEQDDLPEVMAKCVQGTVSWPSTMQTIKGVFTAGITRSVKYVGEKRSKGQQKAKTAPEKAESVSKQLGQGAKAKEEEFDVEEEIGQKKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTN3</accession>
    <name>N1PTN3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_129161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTN3"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="OMA" id="IMLMSSW"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14670)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="66"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME45769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="510" mass="56359" checksum="C428A844BA939E4E" modified="2013-06-26" version="1">MDPDAKHSKQSAELHEIRKSIDNAKSVPLGHGDHEQAAFFEDFATKDADWVEHQNKKLLRKVDLHLLPMLILMYLFNFLDRSNLAQAREGTLEADLGMKGTDFNLATSIFFIGYLLMQLPSNMFITRVRPSFYLAGVTTLWGVVSTCNAATHNFTSLVVVRFFLGFVEAPFFPGVIFLMSSWYTRAELTRRVAWFYSGSSLANMFGGLFAAGILGNLDDAMGLSGWRWLFIIEGTITIFFGLCANLLLPDYPATTRWLTPEERAFAAWRLYSDINESDDTHSAGVWDGIKLALQDYRLYLFTLLQHMSLLSQTFQYFFPSIVRTLGYGNIATLLLTVPVWFATFLTSIIATLTASKTGDRSLHIASLMLIAAIGNAIATATTSVGARFFAMFLMPMGAVSAFVVIVPWIANSFPRPLVKRSACVAIANMIGNTASAYGSYMYPSSAAPQYVPGGSANAVICLGVAALALGLRWAHQRENGKLERAEDEADGNGEVVVGQEMRAVGFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTV2</accession>
    <name>N1PTV2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_70394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTV2"/>
    <dbReference type="STRING" id="675120.N1PTV2"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_12_3_1"/>
    <dbReference type="OMA" id="LMSTCDF"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000118">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005141846" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME46373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="545" mass="60418" checksum="9E6D8746D85A9DFE" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWE4</accession>
    <name>N1PWE4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWE4"/>
    <dbReference type="STRING" id="675120.N1PWE4"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_531135_0_0_1"/>
    <dbReference type="OMA" id="KERMWET"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF156">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="465" mass="51688" checksum="1E9D711F7F5D2A77" modified="2013-06-26" version="1">MQVQGTASQALGSRLCLSARQSYPNTVSSSEKEDLFLLQRTPPDPCRINSLYHMPWRHFVLRHVGHSYMTCAMMSEHLEHNAVQPTAADLRLANLQRWDEEALDVLDLPQLYTKPSAQTLLGSLAQLSSNPPSWDTTPRTTTPRSARSGISPPYSKRRRVRCEGIAPYLTRIIASALSWIEDDNQKEQIWEAASQRLSERSGRSAMGAITRTFVIDMQPSSILERSITRNPSSDSDGTQMDASENNLELTLHEPALTSDNLGLKTWASSYLLAKRLGTLRAYLPSLPRDALILELGAGTGLVGLAAAAVFSRHVILTDLPEIVENLQRNVQTNAPALTVHGAKAYAAVLDWTSPASFTLENIHPGGAGIFPLILVADPIYSTEHPRFLTQAILYHLSRDDDARVIIELPLREAYVAERQDLHTRMAELGLSILHQGEEVGFDDWSSGHDEVLTEVRCWWSVWARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWH5</accession>
    <name>N1PWH5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWH5"/>
    <dbReference type="STRING" id="675120.N1PWH5"/>
    <dbReference type="eggNOG" id="ENOG502S49J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007263_2_0_1"/>
    <dbReference type="OMA" id="DVPYIPR"/>
    <dbReference type="OrthoDB" id="5591786at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="652" mass="71440" checksum="E0724FF36021789C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWI8</accession>
    <name>N1PWI8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_122556</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWI8"/>
    <dbReference type="STRING" id="675120.N1PWI8"/>
    <dbReference type="eggNOG" id="ENOG502QQNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="OMA" id="FYLFHNY"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021863">
        <property type="entry name" value="FAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11960">
        <property type="entry name" value="DUF3474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fatty acid desaturase N-terminal" evidence="8">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="7">
        <location>
            <begin position="133"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME47896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="54646" checksum="853C946320221CE1" modified="2013-06-26" version="1">MSTTALPQKAAMRRTVTVDSVPSTVSNSEASTPDDSPTASASSTSLSSLGSVEDFQQEPEQKLIDTYGNEFKLPDYTIKDIRDAIPKHCFERSAVTGLSYVFRDLVLLASTFYLFHQFCTPEYVPSYPLRTALWAFYTFAQGCFGTGIWVLAHECGHQSFSESKTINDTVGWVLHSALLVPYFSWKISHGKHHKATGNMERDMVFLPRTREEHASRMGVVLHEMHELMEETPIYTAGNLIAQQLFGWPMYLLRNVTGHNNHEKQPEGKGVGKQNGDGSVNHFMPSSPLYEKKDEHLILLSDLGLAITVSVLTLVGRAFGFTNLLVWYILPYLWVNHWLVAITFLQHTDPSLPHYTGDAWNFTRGAAATIDREFGFIGRTLMHGIVETHVLHHYISTIPFYHADEATEAIKPIMGQHYRSDTREGSIGFIKSMYKSARWCQWVEPNEGAKGESSKVLFFRNRNGLGVPPAKITAPSSKKGMVVGDYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWP0</accession>
    <name>N1PWP0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_70708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWP0"/>
    <dbReference type="STRING" id="675120.N1PWP0"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_3_1"/>
    <dbReference type="OMA" id="GMQPWKY"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="210"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME46825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="572" mass="63865" checksum="68F9F3316C435B32" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWQ3</accession>
    <name>N1PWQ3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWQ3"/>
    <dbReference type="eggNOG" id="ENOG502SYRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_670893_0_0_1"/>
    <dbReference type="OMA" id="QEPANIM"/>
    <dbReference type="OrthoDB" id="5015154at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="410" mass="46383" checksum="506399EA2EAA142A" modified="2013-06-26" version="1">MFRTAGRVVKWLLLLTLPITIFPIFSAVFGGITFSIWRQRQIDANVDKFLNEIKNSMNDWGVGGGAPSFREFEDTHNDFHLMRINSNDWTAKMGFLLPEEYTSVESVDVSIDTYASLTTLMRDMSCPDTAKMPKEQWVWLAWYGFPQFDVQWDGAFNHALQYVHAHSNLNESGLFYAQCSGTAGFLCGVWSTRPPALIHFLVEDEPLDDAGGDETLTYSSPRDKLLPVTARIIEFPLQDAYTGLSPNQFSGYKEQILSIIAGDRLYEQFDPYDAVQQTFSHFDEYVNKLWDEKGSLLNRVNKMDDWMIDHVNKPLGIEDTVVFMHSFLFLLAAGATEGLVLLPARVVSQTVGEFLGRPKRGDWILGNLGDKPQEPANIMDDIFGDFWASLGENIAKHQSSMTEESEPVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX10</accession>
    <name>N1PX10_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_21779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX10"/>
    <dbReference type="STRING" id="675120.N1PX10"/>
    <dbReference type="HOGENOM" id="CLU_882847_0_0_1"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="315" mass="35451" checksum="40766E82539120DA" modified="2013-06-26" version="1">MTTLLKGLVNDILTYFEVKIQAKLLDGGESAAEAVELKLIGDKAVEIVTTILCHRRRETPKEEVERIILEHIHQFTSSRGIMEAQLEVHHADDVFELGEVFKLLSTPADADELDTGIVIADTPDIEDMNRYVAANTERYLKHTADLILLIAQYLRLENNVEPLLEKCLQVGKISSTQLVVIKMDQKDLLKKPEIEKLEELLKQKYMAVEAEFKPLYAKLTTQNTGFKKKQQRPKAQAFGPQGSATLQKQCTDAVEHYHDSTEQVRSLGVALHQIVVKSASRKKTEEIQDIMGKVVKPANVREDRSGEDHGDDGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX27</accession>
    <name>N1PX27_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_50487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME46970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX27"/>
    <dbReference type="eggNOG" id="ENOG502S9TZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037437_1_0_1"/>
    <dbReference type="OMA" id="QWRHLFR"/>
    <dbReference type="OrthoDB" id="5521299at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="2">
        <location>
            <begin position="73"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="413" mass="46817" checksum="5437F3E62283C8EF" modified="2013-06-26" version="1">MICWTRRAHAPYNGGRFDLRLTFNASTRSSNTDAPRSARAASTRDHHALKKALSGPKTLFSASERSKRARHTLRALLRECSYLPDPAAKQYLSQHVLSRFRTYGYRAWKHRNEPGYNARLQEKEREARQTLNQLKRANIGASKSLLRILFQTYGRIGKRRHELMRPLMTGNVAEEDGEGLEGAAKNEDIRDTSTEVDRLELADIVSADIAAHGPKPRKEHTISVVQAAKSGIAIPKALPRLTPELYSLAKSQIRTSPASMTRPNPRNLKADVPKLNAKMRPMPTSRVKNMTQKWYANTLDRLLPPLPTSEWLRLQELAAGRGIQEQLAKRRKRPETSSSVPASALERILLRGTFDTPNPTTSDVHEFTPRFMQRLYAAVFGQCPRMDWDVEKERWNVTWGSQTLSRADRSAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXG3</accession>
    <name>N1PXG3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mfs3</name>
        <name evidence="9" type="ORF">DOTSEDRAFT_70757</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXG3"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="OMA" id="PWKELQP"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="21"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="592"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME46914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="668" mass="72291" checksum="F5C8543798913CF2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYC6</accession>
    <name>N1PYC6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_18970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYC6"/>
    <dbReference type="STRING" id="675120.N1PYC6"/>
    <dbReference type="eggNOG" id="ENOG502T7WF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_940170_0_0_1"/>
    <dbReference type="OrthoDB" id="5238363at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="296" mass="33592" checksum="5FE4EF0D121ED746" modified="2013-06-26" version="1">MSAVKAVKHVAKHGLRTAQNAPKAVRAITNEARPSIRYTIDATSGAQSSQHAAIDRRSLSKNREVDQPTLTSTNTPTKPHNNAFLQRSNSPSTKPSRQSALLTFIHEPFPRPINCTTFQSTRLFATDPSHPLYIRTHRRLAAFDPERLTWRVQVPVAVSKKPAIRREAERRVKRAVGAELDGREDFNGALLLIMNKDPMRSLRFRQEEVQKEVRAWVRRTLRERERCNNVTRRERSDDFQRHARELNGGSLRGNIGRDGSEGDPSSWRRVSAQSRGNGRMSLKDGMFKDGENLDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZC2</accession>
    <name>N1PZC2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_124229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZC2"/>
    <dbReference type="STRING" id="675120.N1PZC2"/>
    <dbReference type="eggNOG" id="KOG4409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017361_3_0_1"/>
    <dbReference type="OMA" id="ADQHLVM"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="136"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME47569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="500" mass="56143" checksum="DE9FCD15833C1D8B" modified="2013-06-26" version="1">MLARQRAKEEAQAEPQKHGRDGNPYFPLGYKEGFSQWWAGLAPAVTEHRVMSFIPCLQKPPTHMQTGSEPGTGNNSSLSLDKSKSPANGETQERTTSIHDPHGPRQWQSNMVELSGKNRALNEFSVERLGEEVNNNLVMVHGYGAGLGFFYKNYEALSRLPNWRLYSLDLPGMGRSTRPPFKINARDKEGKIREAESWFVDALEEWRKKKGIDKFTLLGHSMGGYMAVCYALKYPGHLNKLILASPVGIPEDPYAVNEDMPEPGDSTMANEVAQDASVGTVKGDNKPPRRQMPKWLTTLWDANISPFSLVRLSGPLGPRLVSGWTSRRFSHLPADEAQALHDYSYSLFRQRGSGEYALAYILAPGAFARSPLVRRIHGVGRQYLEAHREPSPDNASSRTQDVPRKTRETGLPVVMMYGENDWMDVAGGYAAQERMREEKRKALSQATGREKQLENGDTKVTIIGKAGHHVYLDGYEQFNDEVLNEMKDVEKRQKRLASLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZF5</accession>
    <name>N1PZF5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_84419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZF5"/>
    <dbReference type="eggNOG" id="ENOG502RZT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042059_1_0_1"/>
    <dbReference type="OMA" id="YLLTTFY"/>
    <dbReference type="OrthoDB" id="5394254at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="388" mass="42233" checksum="C074EAE79DC5165F" modified="2013-06-26" version="1">MLARTTTTHARRTLSTASHVPLLAVQSNDQHRADAKTRKSAETNRIPIAGRDSNSALQHIMAPAPADNPMAPRAARIPSALRLPLVVLTTFSLSSLGYSLFAGSAGPELAAVSRDLTSAWHIAAMVVWKLAELSIAWYACYDYLDLAYLTLLNNVPHYFLLNTFYGIDFFATIVPLSIDVVTIAIPFWLFRSLNHGHDTTGVKSDNQRVAQDRGVQSLIALFGSSIYSLVVYGSFATWLPVYIVLHFDRVRSLEKAHSTAVLTLLGLFAPLGYAATQFIFVPAIGSDGNPGITDPQVALERPPFNTETSSLKENVLRFVRLGDTAFTRRAEILLKRTAILAACSFLNTFVRTYFTIEGTELVGAVGWAGVWAAAAGLTGLAYAWVGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q047</accession>
    <name>N1Q047_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_21595</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q047"/>
    <dbReference type="eggNOG" id="ENOG502T67P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209440_1_1_1"/>
    <dbReference type="OrthoDB" id="4150500at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019603">
        <property type="entry name" value="Tom5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10642">
        <property type="entry name" value="Tom5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME47859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="49" mass="5355" checksum="3946F58E48879EE4" modified="2013-06-26" version="1">MFGGPPPPPSAEELRQQELLATATMYQFGIIATLLYFSPFAVDAVKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q082</accession>
    <name>N1Q082_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_67643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q082"/>
    <dbReference type="STRING" id="675120.N1Q082"/>
    <dbReference type="eggNOG" id="KOG0810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042423_0_2_1"/>
    <dbReference type="OMA" id="HPRNAPQ"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF380">
        <property type="entry name" value="SYNTAXIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="213"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME48668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="327" mass="36350" checksum="B11E7801B8181D5F" modified="2013-06-26" version="1">MAYNNNYGGGGGYGQSNPYATNNDAYNNPPPAYGGHNVEMQPLTHNGAPYAATPEPQRDPNAILNDCRAVGRAIDDLEGRLQELQRLQKNFISGSGANNKDVDSLSADIMSGYRGLADRVKRIKSQPDAASPRNQAQVEALDRRIRKAIQSYQTTESAFRKDVQEQQRRQYLIVRPDATEMEIREATEAGADTQIFQQALLNADRRGQAQSTLRNVQQRHEAIQQIERTMIELQQLFQDLDAIVVQQEAPVMAIEQKAEETHTHLEAGNVHVAKAVDSARAARKKKWICLGICVAIIIIIIVIVLAYGATQGWFSSNKNNNKNNNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0F5</accession>
    <name>N1Q0F5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UEV domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_30446</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0F5"/>
    <dbReference type="STRING" id="675120.N1Q0F5"/>
    <dbReference type="eggNOG" id="KOG2391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017548_2_1_1"/>
    <dbReference type="OMA" id="YMNFPQP"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="497"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME49147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="62733" checksum="2B29DB9BB35DCBC8" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0L3</accession>
    <name>N1Q0L3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_69931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0L3"/>
    <dbReference type="HOGENOM" id="CLU_679755_0_0_1"/>
    <dbReference type="OMA" id="FFITTSM"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME48155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44440" checksum="6D552B31BF97D7E9" modified="2013-06-26" version="1">MPMMKDEERQPLLGQQAVQNAAETTREDHGKTSKWTSIFPQIQVTDPRFRFLPLIGCLTVLVNEGEYFFKQIGYFRAVEALYCIEYYHVHDPVVAHLGKAIPENMCKIDSIQKKVATANGIVLLVRMTSAFIGTMIVGYLADMYGRRLPLILHKVGTIIYTVVVASTYLGYPYLPIWVSFCGGLGGLIGANFDLNLAILLAAYNDALTSSTQVATYFFITTSMQYVGQVSFPLLAGKAINMDGKGGTPHVSLFISLGMAAAGLVISVLFFPETMKKSEPPDGPDLSDNGGDGKRKGIKAMIAAKAKSIQEGFQRSVQGVGATNVILLIVAMFLATTAIKAVDWLGLIQYPVIKFGWKYNQSTFAMAIQAVIYIFTYFILLPTYNKLGARYGFSPSSTSLTIMLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1C3</accession>
    <name>N1Q1C3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_122794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1C3"/>
    <dbReference type="STRING" id="675120.N1Q1C3"/>
    <dbReference type="eggNOG" id="KOG3393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096876_0_0_1"/>
    <dbReference type="OMA" id="VHITFVD"/>
    <dbReference type="OrthoDB" id="10591960at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME48284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="177" mass="19241" checksum="BDA80D8CB5FA5FCA" modified="2013-06-26" version="1">MYGDDNMDGHRLFKFPRPQWINSANSRTAGVYLSGSLFCLALFVLIDAQVYSKSHLNGSALHLNFVDWIPAIFSFLGMLVINSIDKTRLSGDTFAYSGDGVAWKARVVLFMGFAAMAGGLAGGVTVMVLKYVTEGATGMSLWFGAANLVANALVMLSSVVLWVSQNMEDDYTYNLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q255</accession>
    <name>N1Q255_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_84274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q255"/>
    <dbReference type="STRING" id="675120.N1Q255"/>
    <dbReference type="eggNOG" id="ENOG502QQ4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_520726_0_0_1"/>
    <dbReference type="OMA" id="EPEFEWV"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="463" mass="54712" checksum="F1CD9F68B42802BC" modified="2013-06-26" version="1">MGDYYGNDDYDYHGRPRRRPSPHHMRSDAGGFLAPGGSGLYRSRSHGASQAPTINVYNRNFQDQEGSPYPPYQGYPPYPAAPSSRRASPRASPEGCSRGRSRLGDKLGDELVDELADMALEHRYRSRSRGRSDASSFDRPPYPPAGLAEWQLAQKEAELKERSRERAWKLEQERIKGKWKLEQMEEELRKEREEDERKKNEKRAVDDYERKIREATQKREADERRWKEDIERKAREAKDKQAAEEQRIKDKIEKGAREKKEKDAAAYRAFKEKERLEKEEKEHEYQEFLREQKEREVKKKREAKEAEEKFQNEMRKRLASLGYTERTIEIMVDEEKAKKFKQEVESGGSDRRTTTTTTTTAIDLFQSPRAPVYPKVHRDYLAVETLKYYDLPWEYDRHNPDYIIILRDMDKRETDLLFEHTSRLRTGKLLLEPAKKEKQFALYRRRSKSRSGRPNEVGVIRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q294</accession>
    <name>N1Q294_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_30144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q294"/>
    <dbReference type="HOGENOM" id="CLU_1133564_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="245" mass="27416" checksum="7B247870DF06335E" modified="2013-06-26" version="1">MCQSPCVLLPTPNDGHSTGQGVSSSRSPSFRISTSGDVRKQRSITGDDVAKPLRSRHDSRRDRWAAPACVQCREQMIVIYDGIDDLRSNGAALGLQVVAVLAVPERDRDGDELLLPSILSREHQAIRDLRIAWTSMFAEADALFDRAETRKQVEDAAGITVPAYLIDHLLHHGNARRAFIREYPRGPWTKFDVAKARLVLATDLRYIWRLGEYANIHCPAEEHERVGFKGTAHNRTLSALRRATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2A7</accession>
    <name>N1Q2A7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_67720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2A7"/>
    <dbReference type="STRING" id="675120.N1Q2A7"/>
    <dbReference type="eggNOG" id="KOG0527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010453_0_1_1"/>
    <dbReference type="OMA" id="CAGPDVT"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="153"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="153"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="573"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME48770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="763" mass="82872" checksum="B01FC32FA6DF1883" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2A8</accession>
    <name>N1Q2A8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_19117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2A8"/>
    <dbReference type="STRING" id="675120.N1Q2A8"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1372184_0_0_1"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22458" checksum="267758F13854A122" modified="2013-06-26" version="1">MKHTPRDKYEEHHSPAHNAWELADRPKDYGIEAAVHLISLLLCNSLILMTPANDPLGIVVELLISNVNHSCVPNACIVFEEIFVSYVDQHGLFHARQAALWHRYYFTCTCPKCKLATQASLERFLPKPEQMPDASKKEADKLLKQLDADPILAAHHLGGSASERRLAAIEAHGHISLKPRRSLYKATQARLSYARLYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2A9</accession>
    <name>N1Q2A9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_20297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2A9"/>
    <dbReference type="STRING" id="675120.N1Q2A9"/>
    <dbReference type="eggNOG" id="ENOG502RZHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013926_0_0_1"/>
    <dbReference type="OMA" id="WHAKAPL"/>
    <dbReference type="OrthoDB" id="5362656at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="503"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="556"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="637"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="698"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="788"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="882"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME49891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="922" mass="99733" checksum="279D34BEEDE36F2A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2R3</accession>
    <name>N1Q2R3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_67853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2R3"/>
    <dbReference type="STRING" id="675120.N1Q2R3"/>
    <dbReference type="eggNOG" id="KOG1646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046346_0_0_1"/>
    <dbReference type="OMA" id="KPRYKAP"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME48945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="241" mass="27716" checksum="57909E8FE2A60BD3" modified="2013-06-26" version="1">MKLNISFPANGSQKLVEVDDERKLRVFMDRRMGQEVPGDSVGDEFKGYIFKITGGNDKQGFPMKQGVMHPTRVRLLLSEGHSCYRPRRTGERKRKSVRGCIVGMDLSVLALAIVKQGEQDIPGVTDTVHPKRLGPKRATKIRRFFGLSKEDDVRKFVIRREVQPKEGKEGAKPYTKAPRIQRLVTPQRLQHKRHRIALKRRHAEASKDAANEYAQVLHKRVNEEKAKQAEMRKRRASSMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2S9</accession>
    <name>N1Q2S9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_67863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2S9"/>
    <dbReference type="STRING" id="675120.N1Q2S9"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_3_1_1"/>
    <dbReference type="OMA" id="AEIMAIC"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="322"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME48960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="532" mass="58177" checksum="919EB6FF5EB0916D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q338</accession>
    <name>N1Q338_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_20563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q338"/>
    <dbReference type="HOGENOM" id="CLU_1272271_0_0_1"/>
    <dbReference type="OMA" id="PLRWLCC"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="217" mass="23699" checksum="14363F6D8E66927E" modified="2013-06-26" version="1">MKDPLPLRWLCCCCPCGPTKPTEKSPSELERDIGSPPTATKLEDDNAYIAEVAINMALRRSTETAERTSLDIGAPIREEVIEPPPPSYDSVWTERPAIPAVRSLCSNSVPMMSSNATSADRDVATSQFPVESQPLGGQNDVKAISSPALAMMQHRRQSAGDAEAPRGLEEDSDFESRISTPRTLTPPTTVPPTLVDGDEDEERRRWVRVEDGGVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3S3</accession>
    <name>N1Q3S3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_68185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3S3"/>
    <dbReference type="STRING" id="675120.N1Q3S3"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="OMA" id="FHEVMET"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000020">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000767">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="142"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="580" mass="64875" checksum="41C8895254711BF0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3T8</accession>
    <name>N1Q3T8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_68205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3T8"/>
    <dbReference type="eggNOG" id="KOG0754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_2_1"/>
    <dbReference type="OMA" id="LPFQYQF"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000034">
        <property type="entry name" value="Mitochondrial 2-oxodicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="108"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="205"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME49345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="304" mass="33346" checksum="43B7B7C1F5AD3E67" modified="2013-06-26" version="1">MSTERPLPFIYQFAAGAVAGVSEILVMYPLDVVKTRVQIQGKVPIPGQDHYTSMMDCFRKIIANEGAGRLYRGINAPILMEAPKRATKFAANDEWGKVYRNLFGVAQMNQSLSILTGASAGATESFVVVPFELVKIRLQDKAQSAKYNGMIDCVQKIIRQEGVLTLYQGLESTMWRHILWNSGYFGCIFQVRALLPANPTKDKSVQMRNDIISGTVGGTVGTILNTPMDVVKSRIQNSPKVAGGVPKYGWAWPSLGLIMKEEGFGALYKGFLPKVLRLGPGGGILLVVFTGVMDFFRNMRGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4I0</accession>
    <name>N1Q4I0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanine nucleotide exchange factor synembryn-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_118881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4I0"/>
    <dbReference type="eggNOG" id="KOG4464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015532_0_0_1"/>
    <dbReference type="OMA" id="NADPIFT"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME50258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50754" checksum="4065119F43B38BE2" modified="2013-06-26" version="1">MPSVRIGRIVRAGQGAWSQCSQCRSHLHEASMCGAQCDQGVLTLSKYGLGKESSNTSREALRCLANAFLLDEPSRQIFVDLGYAPKAAEHLKNDNREDEFLISRMLFLLTYNTKVDFEVLVNDNKLADSINQQIARHAKNFSKSGRRKSVNSPSQDMAMVETLKLLFNVTYYYPDLISCFTPSVEPLINIILHHPLPSPPLQPPLTHILNALLNMDLGAAEKKTPYGREARVSPLFPYSHPETVVDRLSCILDEALRKQEERELDQAAAPLVTLMRRMYELATPQMKSWMRWLLLPTAKDRDKPLGQGETLSARLLRLSCSPNLTTLRENVSGLLFELSDKDATKFVNNIGYGFASGFLVSHNIRIPASAMEASSTSSDDTSGGVDFNPITGQKWSSENRDTSKSVPEMTEDEKEREAERLFVLFERLKATGVIDVKNPVEQAIDDGRFEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5B1</accession>
    <name>N1Q5B1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_121491</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5B1"/>
    <dbReference type="STRING" id="675120.N1Q5B1"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_5_13_1"/>
    <dbReference type="OMA" id="HPWISKC"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="173"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME50335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="470" mass="53206" checksum="C67C619C570A989A" modified="2013-06-26" version="1" fragment="single">MHSEQPQPVNGSNRATSWSTLNPTRPPTKAPPNLVKSRQAAASATISAIIKDKDDLTADDEMKRLSQKRRDVDTAAKDSEELKKRAVARSPKSPENVLHDRTAALNIFERGEIMDYENQGVYFTGTKNARKIIGSLTPSPQPGDKDPKAGNYGYDDERGDYNIVLGDHLAYRYEVVDMLGKGSFGQVVRCVDHKDGGIVAVKIIRNKKRFHQQALVEVGILGRLREWDPDQTHATLSITSSFYFRSHLCIVTPCLSINLYELIRAHNFVGFTLPLIRRFARQLLSCLVLLQNKQIIHCDLKPENILLCEARKADVRVIDFGSSCKESEKVYTYIQSRFYRSPEVILGSSYGLGIDMWSLGCILAELWTGYPLFPGENEQEQLACIMEIFGPPDRHLVERCTRKKLFFDSVGKPRVTVSSKGRRRRPSSKTLSQALKSEDEAFLDFVARCLRWDPDRRLKPHDAVNHPFIT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-02-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJF5</accession>
    <name>HYPC_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Monooxygenase hypC</fullName>
            <ecNumber evidence="9">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Dothistromin biosynthesis protein hypC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hypC</name>
        <name type="ORF">DOTSEDRAFT_75655</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Appl. Environ. Microbiol." volume="68" first="2885" last="2892">
            <title>Dothistroma pini, a forest pathogen, contains homologs of aflatoxin biosynthetic pathway genes.</title>
            <authorList>
                <person name="Bradshaw R.E."/>
                <person name="Bhatnagar D."/>
                <person name="Ganley R.J."/>
                <person name="Gillman C.J."/>
                <person name="Monahan B.J."/>
                <person name="Seconi J.M."/>
            </authorList>
            <dbReference type="PubMed" id="12039746"/>
            <dbReference type="DOI" id="10.1128/AEM.68.6.2885-2892.2002"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Mycopathologia" volume="161" first="283" last="294">
            <title>A polyketide synthase gene required for biosynthesis of the aflatoxin-like toxin, dothistromin.</title>
            <authorList>
                <person name="Bradshaw R.E."/>
                <person name="Jin H."/>
                <person name="Morgan B.S."/>
                <person name="Schwelm A."/>
                <person name="Teddy O.R."/>
                <person name="Young C.A."/>
                <person name="Zhang S."/>
            </authorList>
            <dbReference type="PubMed" id="16649078"/>
            <dbReference type="DOI" id="10.1007/s11046-006-0240-5"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Fungal Genet. Biol." volume="44" first="1342" last="1354">
            <title>A fragmented aflatoxin-like gene cluster in the forest pathogen Dothistroma septosporum.</title>
            <authorList>
                <person name="Zhang S."/>
                <person name="Schwelm A."/>
                <person name="Jin H."/>
                <person name="Collins L.J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="17683963"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2007.06.005"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2010" name="Toxins" volume="2" first="2680" last="2698">
            <title>Genetics of dothistromin biosynthesis of Dothistroma septosporum: an update.</title>
            <authorList>
                <person name="Schwelm A."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="22069571"/>
            <dbReference type="DOI" id="10.3390/toxins2112680"/>
        </citation>
        <scope>REVIEW ON FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2013" name="Fungal Genet. Biol." volume="51" first="12" last="20">
            <title>Dothistromin genes at multiple separate loci are regulated by AflR.</title>
            <authorList>
                <person name="Chettri P."/>
                <person name="Ehrlich K.C."/>
                <person name="Cary J.W."/>
                <person name="Collemare J."/>
                <person name="Cox M.P."/>
                <person name="Griffiths S.A."/>
                <person name="Olson M.A."/>
                <person name="de Wit P.J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23207690"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.11.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2013" name="New Phytol." volume="198" first="525" last="535">
            <title>Fragmentation of an aflatoxin-like gene cluster in a forest pathogen.</title>
            <authorList>
                <person name="Bradshaw R.E."/>
                <person name="Slot J.C."/>
                <person name="Moore G.G."/>
                <person name="Chettri P."/>
                <person name="de Wit P.J."/>
                <person name="Ehrlich K.C."/>
                <person name="Ganley A.R."/>
                <person name="Olson M.A."/>
                <person name="Rokas A."/>
                <person name="Carbone I."/>
                <person name="Cox M.P."/>
            </authorList>
            <dbReference type="PubMed" id="23448391"/>
            <dbReference type="DOI" id="10.1111/nph.12161"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 4 5 8 10 11 12">Monooxygenase; part of the fragmented gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B (PubMed:12039746, PubMed:17683963, PubMed:22069571, PubMed:23207690, PubMed:23448391). The first step of the pathway is the conversion of acetate to norsolorinic acid (NOR) and requires the fatty acid synthase subunits hexA and hexB, as well as the polyketide synthase pksA (PubMed:16649078, PubMed:23207690). PksA combines a hexanoyl starter unit and 7 malonyl-CoA extender units to synthesize the precursor NOR (By similarity). The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by the fungal fatty acid synthase hexA/hexB (By similarity). The second step is the conversion of NOR to averantin (AVN) and requires the norsolorinic acid ketoreductase nor1, which catalyzes the dehydration of norsolorinic acid to form (1'S)-averantin (PubMed:23207690). The cytochrome P450 monooxygenase avnA then catalyzes the hydroxylation of AVN to 5'hydroxyaverantin (HAVN) (PubMed:23207690). The next step is performed by adhA that transforms HAVN to averufin (AVF) (PubMed:23207690). Averufin might then be converted to hydroxyversicolorone by cypX and avfA (PubMed:23207690). Hydroxyversicolorone is further converted versiconal hemiacetal acetate (VHA) by moxY (PubMed:23207690). VHA is then the substrate for the versiconal hemiacetal acetate esterase est1 to yield versiconal (VAL) (PubMed:23207690). Versicolorin B synthase vbsA then converts VAL to versicolorin B (VERB) by closing the bisfuran ring (PubMed:16649078, PubMed:23207690). Then, the activity of the versicolorin B desaturase verB leads to versicolorin A (VERA) (PubMed:23207690). DotB, a predicted chloroperoxidase, may perform epoxidation of the A-ring of VERA (PubMed:23207690). Alternatively, a cytochrome P450, such as cypX or avnA could catalyze this step (PubMed:23207690). It is also possible that another, uncharacterized, cytochrome P450 enzyme is responsible for this step (PubMed:23207690). Opening of the epoxide could potentially be achieved by the epoxide hydrolase epoA (PubMed:23207690). However, epoA does not seem to be required for DOTH biosynthesis, but other epoxide hydrolases may have the ability to complement this hydrolysis (PubMed:23207690). Alternatively, opening of the epoxide ring could be achieved non-enzymatically (PubMed:23207690). The next step is the deoxygenation of ring A to yield the 5,8-dihydroxyanthraquinone which is most likely catalyzed by the NADPH dehydrogenase encoded by ver1 (PubMed:23207690). The last stages of DOTH biosynthesis are proposed to involve hydroxylation of the bisfuran (PubMed:23207690). OrdB and norB might have oxidative roles here (PubMed:23207690). An alternative possibility is that cytochrome P450 monoogenases such as avnA and cypX might perform these steps in addition to previously proposed steps (PubMed:23207690).</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 11">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6">Expression is positively regulated by the dothistromin-specific transcription factor aflR (PubMed:23207690).</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="9"/>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJF5"/>
    <dbReference type="SMR" id="M2WJF5"/>
    <dbReference type="STRING" id="675120.M2WJF5"/>
    <dbReference type="GlyCosmos" id="M2WJF5">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EME39098">
        <property type="protein sequence ID" value="EME39098"/>
        <property type="gene ID" value="DOTSEDRAFT_75655"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SBMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105974_0_0_1"/>
    <dbReference type="OMA" id="PFTWVFM"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF3">
        <property type="entry name" value="ANTHRONE OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000443477" description="Monooxygenase hypC">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q12437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="12039746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16649078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="23207690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="17683963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="22069571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="17683963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11">
        <source>
            <dbReference type="PubMed" id="23207690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="12">
        <source>
            <dbReference type="PubMed" id="23448391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME39098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="185" mass="20026" checksum="54C87B78C60DBF98" modified="2013-05-01" version="1">MLRAATNLYSPPNTGKMSPKTIGSDVGIEVIPVMTGTFLSGAMMSLFLLTIPVILETTTVPSQLLNQWHRIFYRGHIQGPLISIATGLLYSYAAYQRSQRGAAWKPFAVSAAVTVAMIPFTWVFMANVNNSLFRAVAVTEKGGEGNWNEAQGLVRSWGAWNAVRALFPLSGAVLGLLSTCKIVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2WKC8</accession>
    <name>M2WKC8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">MGS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_159715</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WKC8"/>
    <dbReference type="STRING" id="675120.M2WKC8"/>
    <dbReference type="eggNOG" id="KOG2555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016316_3_2_1"/>
    <dbReference type="OMA" id="IKHNNPC"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME39418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="599" mass="65679" checksum="C0A9EE428F2C5F90" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2WLJ8</accession>
    <name>M2WLJ8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_53861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WLJ8"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OMA" id="IGSFFQW"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF25">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="12"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="465"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME42883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="496" mass="54352" checksum="FB3CD7F9996EA09C" modified="2013-05-01" version="1">MTKLGTLRAYYLGTVCCIGGFLFGYDSGIIGGVLTLASFQHDYRYGSDRKTFVTSLAVALQQLGAFVACFAIWPITHRYGRKWSIALCSFIFCIGALIQTIDTHSRSAFYVARVIAGLGLGGSSVVVPMFSSEMTPRQLRGQIGSFYQLMFTFGIFTSYWVDYGVAQNISKTATRQWQIPVGLQLAPAALLGLGMLTLKESTRWLTAQGRHNEAWESLKWIRADDSEATQVEMEEIRAGVEYEAHAREGFRFTELVDKHNFKRTATAAAVFTAQQATGATAFAYYGPQYFKLLVGSKGNNDLLLTAIFGAVKVAACGLFVLFVADNVNRRTVLTGGALFMAACQISTSAVLKTHPPPKNADITSAGIATIALIYLFVIAYNFSWGPLPWPYVAEIFPARIREPGIGIGVAFQWLFNFVFSLTTPYMINNMGWGTFLLWGLFDVVIAGYAWFGLVETRGKTLEEISGPAVGRSDSGSGSAKYIDDREPGKVPQLSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2XK71</accession>
    <name>M2XK71_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_72353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XK71"/>
    <dbReference type="STRING" id="675120.M2XK71"/>
    <dbReference type="eggNOG" id="KOG3867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_11_1_1"/>
    <dbReference type="OMA" id="QARYMEI"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000044">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.10:FF:000005">
        <property type="entry name" value="Arylsulfatase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF46">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="18"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME42882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="642" mass="72488" checksum="D9201B4DC70D4E9D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2XK75</accession>
    <name>M2XK75_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_153057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XK75"/>
    <dbReference type="STRING" id="675120.M2XK75"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020492_1_0_1"/>
    <dbReference type="OMA" id="LHHNDLV"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11051">
        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME42887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="63913" checksum="9BED76280688BA40" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKF7</accession>
    <name>M2XKF7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKF7"/>
    <dbReference type="HOGENOM" id="CLU_1660719_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="159" mass="18182" checksum="9E92B292096FDE95" modified="2013-05-01" version="1">MRTGASLRWGGEIATMLDQPRRRYRLGVVLERSCNIARVHRMNLIMLDGASLARRECLYSLHVSYAQCGANRRQALTTRYDHFPRLHSNSIGHMCRAVSHHHRLLACRTALRHHGPARDEMKPVSPVNAMDLCHTVWPCAYAVDVHLGALVWQRQLRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2XM25</accession>
    <name>M2XM25_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_35748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XM25"/>
    <dbReference type="STRING" id="675120.M2XM25"/>
    <dbReference type="HOGENOM" id="CLU_1266865_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="218" mass="25344" checksum="A4D4A5E9BFE85D0D" modified="2013-05-01" version="1">MEAFRSQWDIPTDFLIVHATNRPGQKLWDEVMNTHRYESASTTIGYAHEQCHIEGVLPHLEDPGQSMHPSRFPRRSRWDASCGWQSSTKISYRRVTNLSLTDRGMLMQKDTDRLEATQLTASRLSLRVPYSLRRGGLSVPQLYESGDFALFVAAQSFISYDWQWYALFYEPEHAVTPAVFLHFVSASALRTNLRFLNRKTERIAIRDIRRPDQHINDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2YK34</accession>
    <name>M2YK34_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_38476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YK34"/>
    <dbReference type="eggNOG" id="ENOG502RM5D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_429618_0_0_1"/>
    <dbReference type="OMA" id="VNEEEYM"/>
    <dbReference type="OrthoDB" id="3647549at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="637" mass="70825" checksum="979B2CBF59F6566B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2YK76</accession>
    <name>M2YK76_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DOTSEDRAFT_75165</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YK76"/>
    <dbReference type="STRING" id="675120.M2YK76"/>
    <dbReference type="eggNOG" id="KOG3052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040334_1_1_1"/>
    <dbReference type="OMA" id="WVKKFKW"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="20">
        <location>
            <begin position="97"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EME39366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="328" mass="36153" checksum="A4454BAE54E6B6CF" modified="2013-05-01" version="1">MLSRTAIKAARAFGAAKGAANNTAKRNASSQSSSESTASWGNTALLTSSTAAAAASVAFYWYQFGRPAYAMTPAEEGLHATQYPWEHEKYVKTFDHSALRRGFQVYREVCASCHSLSRIPYRSLVGNIMTVDEAKVLAEENEYDTEPNDEGEIEKRPGKLSDYVPSPYKNDEAARAANNGALPPDLSLIVKGRHGGCNYVFSLLTGYPEEPPAGAVVQEGLNFNPYFPGTGIAMARVLYDGLVEYDDQTPATTSQMAKDVVEFLNWAAEPEMDERKKMGWKVMVIGTTLFAMSVWVKRYKWSTIKTRKLAYQPPSASQPKQPGGVFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKC5</accession>
    <name>M2YKC5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKC5"/>
    <dbReference type="HOGENOM" id="CLU_2454714_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="89" mass="10430" checksum="427FCE21B99F7E59" modified="2013-05-01" version="1">MVQPRKSKGECSMVSMVQIGLRARFQRLWRWRDASGSYRSWAVSRAQVEGGRDHDGEHDYVQETRADVSQHRQYPHISNRPTTRPPNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKJ6</accession>
    <name>M2YKJ6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_83155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKJ6"/>
    <dbReference type="STRING" id="675120.M2YKJ6"/>
    <dbReference type="HOGENOM" id="CLU_066466_1_0_1"/>
    <dbReference type="OMA" id="WSGAVIT"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004029471" description="Concanavalin A-like lectin/glucanase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26659" checksum="1E6BFB6442ABA40C" modified="2013-05-01" version="1">MLTTLALALLATSTTASPTKRQTQVRTKNYSGAKLLSSPDGTIFTYATTIINVPDTQFVSAEGSPGQLQASAAWVGYGGMEDNGIAQTGCVFDNDGQDDRYARCWTEFYPDPPVFYDDLPSPDIGDWIQLELYLTSPTTATSIVTNTNTGDQASRDFTAPDGHSVSGNNAEWIVENPGARNNLVNFQKEFFEGCQAVTQAGNSYGPGDGNVEVFYEAKDLGDGNGATQWTNSFLPSDSEVEVDWTGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2YN67</accession>
    <name>M2YN67_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_63630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YN67"/>
    <dbReference type="STRING" id="675120.M2YN67"/>
    <dbReference type="eggNOG" id="ENOG502R82D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041583_1_0_1"/>
    <dbReference type="OMA" id="FHRTSKW"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME43395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="293" mass="32928" checksum="6A9645D7C0ADB168" modified="2013-05-01" version="1">MGSRSRTWKKPSLKYGRPPTAQRLKASISSKATQKTIVTFHQLNRDLERARASGDQAQIKRFQQQIDAIGGIKAYQQASIQGQAVDRGGDSSTILLKWLEPVREELLKASPKMKMLEIGALSTRNACSRSGVFDVTHIDLNSQGPGIEQQDFMARPLPAGADDKLDVVSLSLVLNFVPDAKVRGEMLRRTTTFLQHRISSSSNEIGKVMPSLFLVLPAPCVTNSRYFDDHQLGRIMGSLGYALMHRKETAKLVYYLWHLQHRQALEQQSFAKTKIRDGRTMNNFHVVLQRPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBF7</accession>
    <name>N1PBF7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_161036</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBF7"/>
    <dbReference type="STRING" id="675120.N1PBF7"/>
    <dbReference type="eggNOG" id="ENOG502S4WS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084284_0_0_1"/>
    <dbReference type="OMA" id="WTYFERG"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME38227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="248" mass="27957" checksum="0464475AE6ECF611" modified="2013-06-26" version="1">MRAASRLLASVQKGAQFLEAGTPTGLTGVQTHASPRTTLLYTYHTTLEKLKQFPEHSVYRQSVEALTKHRMQIVEQVKPAGLEEWQKRVLAVAESRPDAFKAVPILTPSGNKEVNIVWKAAAVKAANKRTDEWDDEIVGKPHEEGIRTEEERAYMGKEFARDLTEEERQIPRIESEPPLSLEQINEIETKIGAGLIEEVIMVAEGESTLCDTLLQAQVWEDLEEKPQDGQWAYHERDTFTKGTQAPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBN5</accession>
    <name>N1PBN5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_140883</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBN5"/>
    <dbReference type="HOGENOM" id="CLU_2855837_0_0_1"/>
    <dbReference type="OMA" id="PKNFCEA"/>
    <dbReference type="OrthoDB" id="3648802at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CFEM" evidence="9">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME38512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="65" mass="6794" checksum="0A4BEF385520F62C" modified="2013-06-26" version="1" fragment="single">IPAVTDLPLCAQGCVIGYGNCDPSDVKCICTNKPYLDPIVGCVKDSCSPFLVQGLSDPKNFCEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBP5</accession>
    <name>N1PBP5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBP5"/>
    <dbReference type="HOGENOM" id="CLU_1635342_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="162" mass="16701" checksum="2A1DC4A7FB3AAEF4" modified="2013-06-26" version="1">MTFCCIDSMNIPNLQTDPRACCSDPARVFTAGFAAYLAGPSVSTAVPTTSCYAYGCRVATATTTYRPSYTYRPPSSASTSGSFDDGVGSAMGAVIGVVCGSFGLVVVLCILSSLAKRRKVHGSALTQVQVQVHVGADGNAARVSESVGQLPPSYEAVMANRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBR5</accession>
    <name>N1PBR5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBR5"/>
    <dbReference type="HOGENOM" id="CLU_2108952_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="115" mass="12852" checksum="9FC904844EAC570D" modified="2013-06-26" version="1">MLDRLNIPSATIIGADRSRRTASTCTVAVDTDFGRWSHRGLLATLHSIRNTPLPLAETGRHDGEDYTPDSGKNRGLQYEAWSQERCTSGPGSDRCRWESQTALGEERLWVRVPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC29</accession>
    <name>N1PC29_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_181437</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC29"/>
    <dbReference type="STRING" id="675120.N1PC29"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_11_0_1"/>
    <dbReference type="OMA" id="WEAFGPF"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000098">
        <property type="entry name" value="Gly-Xaa carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="16">
        <location>
            <begin position="294"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME38328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="595" mass="65935" checksum="3E47EDE8F25501DA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC32</accession>
    <name>N1PC32_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_48585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC32"/>
    <dbReference type="STRING" id="675120.N1PC32"/>
    <dbReference type="eggNOG" id="KOG4455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110781_4_0_1"/>
    <dbReference type="OMA" id="YPGFLFY"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME38333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="109" mass="11976" checksum="81CBA32C8E91B705" modified="2013-06-26" version="1">MLDERELAIHPIQPESVQHNARTVSNIRALTASLFGVAAGTLGLESLPGFIFYFLGTAIVSSLIFSLKAEQNPKAYFFRPLGDLWAGDMFGGLMSFVLTWTLFYGLCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCC1</accession>
    <name>N1PCC1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_138071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCC1"/>
    <dbReference type="STRING" id="675120.N1PCC1"/>
    <dbReference type="eggNOG" id="KOG0988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001366_2_0_1"/>
    <dbReference type="OMA" id="GIMDETN"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF17">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="144"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="947" mass="106757" checksum="7DEB0A9BED4E3BEA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCH6</accession>
    <name>N1PCH6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_57600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCH6"/>
    <dbReference type="SMR" id="N1PCH6"/>
    <dbReference type="STRING" id="675120.N1PCH6"/>
    <dbReference type="eggNOG" id="KOG3440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115154_1_0_1"/>
    <dbReference type="OMA" id="PLAQWYT"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099617">
        <property type="term" value="C:matrix side of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME38548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="126" mass="15010" checksum="94CB70AD7A4F9AF3" modified="2013-06-26" version="1">MSTPSLAPYIMKRPWLQRWMKPLSQWYFDNAGYRKLGLRADDLIPEENPQVQLALKRLSPKEAYDRVFRMRRAFQCSLAHQLLPKNEWTTQETDTPYLSPLIVEIETEIKEREDLETMQITKPKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCT2</accession>
    <name>N1PCT2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase small domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_137756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCT2"/>
    <dbReference type="STRING" id="675120.N1PCT2"/>
    <dbReference type="eggNOG" id="KOG3191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_6_1_1"/>
    <dbReference type="OMA" id="DVNRNAC"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000274">
        <property type="entry name" value="ERF1 methyltransferase catalytic subunit MTQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27072" checksum="DF7BCDA615675A5A" modified="2013-06-26" version="1">MLPTPSTSHVNYDQIYEPAEDSYLLLDTLSSPGETAFLKNHFSVTTTPPLVLEVGPGSGVVLAFVTANAEYIFGRTDIAAIGADVNMFACKATTQTVKGAVAENKPKAGTFLDVISGDLTSSFLHRCVDVLIFNPPYVPTEELPPHPQDAMSDMPLKSSGTFERDSHLLALSYAGGADGMETTDRLLAQLPTVLSKRGVAYVLLCAQNKPKEVAAKIRAWPDGWSADLVGSSGKQAGWEKLCILRIRRDEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD02</accession>
    <name>N1PD02_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_75756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD02"/>
    <dbReference type="STRING" id="675120.N1PD02"/>
    <dbReference type="eggNOG" id="KOG0427">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_15_0_1"/>
    <dbReference type="OMA" id="WQMDIKV"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000072">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME38304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="156" mass="17712" checksum="EDD06ED75507F0F2" modified="2013-06-26" version="1">MAGMSGKRLQKELAKIQQPLPPGITLVSAPDLKQWEMDIQVLDNPLYNPEEKYRLKFSFSPQYPIEAPEVVFAKLTDPPRPIPIHPHVYSNGIICLDLLDKQGWSPVHNVESISLSLQSMLASNTKNERPPGDAEFVKSNRQRPRDISFLYHDPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD56</accession>
    <name>N1PD56_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_27169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD56"/>
    <dbReference type="STRING" id="675120.N1PD56"/>
    <dbReference type="eggNOG" id="ENOG502RKWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_630085_0_0_1"/>
    <dbReference type="OrthoDB" id="3885367at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME40528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="435" mass="48525" checksum="E1737D26A29CA5F2" modified="2013-06-26" version="1">MTLNPAKDMQPIFPAVDAVPKAKREKDCCICYGNVKTLSRPPPSHVCKDYTGTRIPNKACKECWEAHISTEVEVKPFGQVACMFCPEILVLNRQDKKLCDWSAVGARIDNKYRYDMKYTNATKYKCMARCQNVNTPLQSYFRSTDGRIFTCNLCAFAVCTDCDRPEHVGQTCEEHQSTLPAHHKEAEADTTSCFKRCPECQIPFSTEKGCGYVQCAAGNTMTKKGVVGGCGHRFCEHCLIPWTGDGSAYLGGQMQHGTTSTGALCRYYVRDHDSDHGLSHRFSHQSQAEMKAALPEELHEQFQQQVDMMTADAEKRAGDKMKREARNAEAGEGEDAGSKKRKISKSNIVDSEAEDDLDADPWQSTEAESPPPKPVKVSKRGKKAVGEPTGPKQPKQISPETKANREKQAVRREKRKGLEQKKREMQNPSAEMLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDA9</accession>
    <name>N1PDA9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_137232</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDA9"/>
    <dbReference type="STRING" id="675120.N1PDA9"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OMA" id="PLIKVYM"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME40084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="295" mass="32320" checksum="95D30E9E7751E153" modified="2013-06-26" version="1">MNTTTGELLAVKQVEVNPKAANTDPAKIREMVKALDLEIDTMQHLDHVNIVQYLGCERKEYSISIFLEYISGGSVGSCLRKHGRFEEPVVSSLTRQTLCGLAYLHSEGILHRDLKADNILLDLDGTCKISDFGISKRSANPYNNDITNSMQGSVFWMAPEVIRAQSQTLTAATSTSSSTSSSLDVTSSAGYSAKVDIWSLGCVVLEMFAGRRPWSKEEAIGAIYKLGSLNQAPPIPDDVSTVVGPAALSFMYDCFTIDPGERPTADTLLRAPFCIFDPHYNFLDTELYAKIRGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDJ9</accession>
    <name>N1PDJ9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DOTSEDRAFT_137279</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDJ9"/>
    <dbReference type="STRING" id="675120.N1PDJ9"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003731_0_0_1"/>
    <dbReference type="OMA" id="MRTHNEM"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000289">
        <property type="entry name" value="Osmosensing histidine protein kinase SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="17">
        <location>
            <begin position="562"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="18">
        <location>
            <begin position="955"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="420"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="719"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="846"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="912"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1106"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="851"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="929"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1126"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="14">
        <location>
            <position position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EME40174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1139" mass="123219" checksum="D11C60737415EF9D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDS0</accession>
    <name>N1PDS0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDS0"/>
    <dbReference type="eggNOG" id="ENOG502SWE9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143026_0_0_1"/>
    <dbReference type="OMA" id="PMTPIAE"/>
    <dbReference type="OrthoDB" id="5294241at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="138" mass="14859" checksum="B4FBB3B9C0DF4531" modified="2013-06-26" version="1">MSFSPSSSQTSTPTPTPMHSPATQPMSISSTCSSARSSFSSSRTSNPYSSVAYPSWSQGSALRKATSGTASSYVSDEDLYGDDDEHYLSEPPPPPRSAERWMAQPLLPPVYATKPRQSTSASSSSKKKRRSSTEKPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDZ1</accession>
    <name>N1PDZ1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDZ1"/>
    <dbReference type="HOGENOM" id="CLU_2941688_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="60" mass="6812" checksum="A2084D92F79DF776" modified="2013-06-26" version="1">MRWWSIKAADVSLAVVRVELTDKQNDGDIMTKRQFSANATRRSVSLRMQALPMIELSSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE12</accession>
    <name>N1PE12_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_74219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE12"/>
    <dbReference type="STRING" id="675120.N1PE12"/>
    <dbReference type="eggNOG" id="ENOG502SIPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_3_2_1"/>
    <dbReference type="OMA" id="SGHAWGM"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07729">
        <property type="entry name" value="AHL_lactonase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="60"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME40597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="287" mass="32220" checksum="D9B35964C808333E" modified="2013-06-26" version="1">MSTQITSTFGLDLVNQAPEGTKLWLLHCGNLEADDGWFMRGGTTSTASNPTPTSKRRKCVIISVLIEHPTEGLILFETGGGENYPDVWGAPLNDIFARVDYEPDHELPAQIKKTGHDIKDVKAVIMGHMHLDHAGGLENFRGTDVPIWVHELELKHAYYSVATKSDLGVYLPKDLGFDLNWKAIHGPFLEIAPGINLRHSPGHTPGLMIMQVNLKESGTWIFTTDQYHVFENFDSDVPQGWLARDHDDWVTSHQMIKALQKRTNGKMVFGHCADTFFKYKLSPHAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE72</accession>
    <name>N1PE72_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_39468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE72"/>
    <dbReference type="HOGENOM" id="CLU_1224744_0_0_1"/>
    <dbReference type="OrthoDB" id="10560263at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="226" mass="25731" checksum="3AD39A92E8E49029" modified="2013-06-26" version="1">MADDKNHCLLVMLTQNSADISSFTTLMVKPCDRISHSLLKNTRPSHRTMNFHQDMEQAQGFETCHQVLATAELFQEILLNLSTQVLSVAAHVSTDWAQAVKKIFLLPRRIRCIPGGWNLCVREYKPVGHIRKNEPPTNPDLQVTFTEVDHSRAVLFAVQREDGIEYVDLMCDEHGPWRLLAPFAFGFMVSARASVFRLQLFSEEGQDPYLDVAFDVESTKKQVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE90</accession>
    <name>N1PE90_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_91007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE90"/>
    <dbReference type="STRING" id="675120.N1PE90"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="CAGINRR"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="235" mass="24754" checksum="9B02FD8B13BF24F3" modified="2013-06-26" version="1">MAAQVPIVDVSCLFSLSGKSAIVTGGSGGLGLSMTTALASAGADIVSIELPNEPSSSAVASAISKAGRNLRQYHSDIRDSKHLHGDVKGDILLNCAGVQRRADADSFTDEEIEVVLDVNLKATLVSCQEFAKPLLKEGSSGKIINIASNICFIGVKNITPYAVSSGGVLYFHTPLTEQYQTDPKCKEFNDHVMMRTPAKRWGDPVDLAGAIIFLARSASDSVRGMSVVVDGGWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEG7</accession>
    <name>N1PEG7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_74753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEG7"/>
    <dbReference type="STRING" id="675120.N1PEG7"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029389_0_2_1"/>
    <dbReference type="OMA" id="MHRIMVT"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="6">
        <location>
            <begin position="116"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME39995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="410" mass="45195" checksum="CBE0BBE8CB5CCD19" modified="2013-06-26" version="1">MSQFPGQGYHNQYPPQQGYGAPPPPQYGGYPQQYGGPSPQPPYNSGYGAPPPPQYGNGYQQGPPPQQYQQPPPQHFQQPPPQQGYGRPPPPPTQQQGFGQGAPQGYSFQYSQCTGRRKALLIGINYFGQRGQLRGCINDVKNMSTYLNGHFGYKREDMVILTDDQQNPMSQPTKQNILRAMHWLVKDARPNDSLFFHYSGHGGQTKDLDGDEEDGYDEVIYPVDFRQAGHIVDDEMHRIMVQSLQQGVRLTAIFDSCHSGSALDLPYIYSTQGVLKEPNLAKEAGQGLLGIVSSYARGDLGGIASTAMGLFKKATSGSDTYERNLRTKTSPADVIMWSGSKDSQTSQDANIAGQATGAMSWAFITALKKAPTQSYVQLLNSIRDELEGRYSQKPQLSCSHPLDTNILYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEW0</accession>
    <name>N1PEW0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEW0"/>
    <dbReference type="STRING" id="675120.N1PEW0"/>
    <dbReference type="eggNOG" id="ENOG502S8NQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_452845_0_0_1"/>
    <dbReference type="OMA" id="RNEECEC"/>
    <dbReference type="OrthoDB" id="10249419at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF3">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G06020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="70559" checksum="0192E16D249CC828" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEY7</accession>
    <name>N1PEY7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEY7"/>
    <dbReference type="HOGENOM" id="CLU_1855227_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="138" mass="15777" checksum="1DC7348A0ABB8E02" modified="2013-06-26" version="1">MKILLTQLQRLDISARPCLAWTGYSASGITNSGLLSTSTWLGCSFVCTKAAPARILTRRPCAQHVRAKHEAARFFGRICSHIFERLDHRSRHEDVHVPRWNRCTVCDKHVKARSMDMYLWTASHKRCSGNSEATLLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF89</accession>
    <name>N1PF89_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_74342</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF89"/>
    <dbReference type="STRING" id="675120.N1PF89"/>
    <dbReference type="eggNOG" id="ENOG502R1BY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013691_3_0_1"/>
    <dbReference type="OMA" id="NIANNWY"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109785" description="tyrosinase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="68"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase C-terminal" evidence="13">
        <location>
            <begin position="447"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME40759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="641" mass="68994" checksum="9B493753941B28B5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFA3</accession>
    <name>N1PFA3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_46310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFA3"/>
    <dbReference type="HOGENOM" id="CLU_2904173_0_0_1"/>
    <dbReference type="OrthoDB" id="3660917at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="62" mass="6848" checksum="D4D0BCCE46201CFF" modified="2013-06-26" version="1">MDIFHVEHKGVHRSLTADRGPIHAVALPRRLTRAVCHQTPSDQEVEDIMRGAAGAPVPEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFI6</accession>
    <name>N1PFI6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-ribosomal peptide synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nps5</name>
        <name evidence="4" type="ORF">DOTSEDRAFT_179405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFI6"/>
    <dbReference type="STRING" id="675120.N1PFI6"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002220_2_0_1"/>
    <dbReference type="OMA" id="IWFFPEG"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="564"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1086" mass="118838" checksum="5F9847DE77E63A3E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFP1</accession>
    <name>N1PFP1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Superoxide dismutase 1 copper chaperone</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Superoxide dismutase copper chaperone</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_73562</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCS1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFP1"/>
    <dbReference type="STRING" id="675120.N1PFP1"/>
    <dbReference type="eggNOG" id="KOG4656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056632_0_0_1"/>
    <dbReference type="OMA" id="KNVWEER"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000038">
        <property type="entry name" value="Superoxide dismutase 1 copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="10">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME41172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="244" mass="25986" checksum="0240404015164AEB" modified="2013-06-26" version="1">MTIPTFETTFAVPLSCEDCIKDVSTSLYKLNGISNVSADLKSQLISITGNAAPSAIVSAIQDTGRDAILRGSGRAESAAVCILETHSTKVQDHVRGLIRMVQVSDSMTILDMTLKGVSPGTYNVTVRETGDISDGAASTGGVWDAIAAKREGRSRVKGVFGTIDVGKSGLGSVFIDKPIQIWELIGRSAVVSRKTEQFEKEDPDTLVGVIARSAGVWDNDKTVCSCSGKTVWEERKEQTAKGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFZ2</accession>
    <name>N1PFZ2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_73632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFZ2"/>
    <dbReference type="STRING" id="675120.N1PFZ2"/>
    <dbReference type="eggNOG" id="ENOG502S4R7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030267_0_0_1"/>
    <dbReference type="OMA" id="AHEDWDY"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="449" mass="48707" checksum="62833ED0909F70CD" modified="2013-06-26" version="1">MEDGTASTGGSGDRRKTVSGPFPPFDVNYDEDDGHVKFSSEAMRLPWSATASPSSSTTPTGPVSVPALRSTAHKRSLSGNILSRLNFLGRPPSRGEQDAPQLPKSPKSTKSRKSIDDDNGSAVSPVSPVKGESAMAAVLKSTKTRKRKGSLRKTALLGGRRLVTEGRERKNSLLQRGPSAKQAMLVQQALPVGPAEPIEVDFNQPVYSQNNDSNSSLRNKFSYESVDANNSSDSGWSESAAATSARLSLLTDHKAQLGDRNASAELTSPLELKSPVSQASYTSTTDDDDILTFDRPANSFAAQARETLTLHQPLSSVATSYFPSVGSVSDVSIARRLSSKKRSSPLSHNITFPEPETHDYTETEFWGWVILFVTWLTFTVGMGSCLEIWSWAWDVGETPSAPPDLEDDPTLPIVGYYPALIVLTGVVAWVWITVAWIGMKYFRHAKIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG52</accession>
    <name>N1PG52_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_137184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of methyl groups from S-adenosyl-methionine to the C-24 of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Steroid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG52"/>
    <dbReference type="STRING" id="675120.N1PG52"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039068_5_3_1"/>
    <dbReference type="OMA" id="HMVKGTF"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="7">
        <location>
            <begin position="69"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME41094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="380" mass="42983" checksum="2969188726244D27" modified="2013-06-26" version="1">MDIAPDNSIYAVRDRPAVGKEEGREAGKTKAYNSAARYQDIWGETDYVDQTEDERVERNKHGDKLAEAYYDFITDHYQGGWGDRFHFCGYYPGESWDVAMARYEHHLALSMELKPGMKVLDVGCGVGAPAREIAKFVGCHITGVTINDLHVERSNKYNADDGLADQVHMVKGTFTDLPFPDASFDAVYATEAICHATDMLKACQELHRVLKPGGRVGLIDWVITDKYDNNNPKHRQIRSEIERGSSVPRLITVQGHINALEEAGFTMELEQDRAIDKSNPIGWWTTLAGQTYPGMTLRDRFTCFMLTKPMYTVLWTIWKALDIFKLCHPARMQALETVAMCVYGCRDGGVWGIFSPMHLFVARKVEEEGEVGEGRKKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG76</accession>
    <name>N1PG76_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA 4-demethylwyosine synthase (AdoMet-dependent)</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_82556</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG76"/>
    <dbReference type="STRING" id="675120.N1PG76"/>
    <dbReference type="eggNOG" id="KOG1160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007952_1_2_1"/>
    <dbReference type="OMA" id="FHVNGKW"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="14">
        <location>
            <begin position="116"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="409"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="721"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="726"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME41114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="759" mass="84989" checksum="60E40878963E763C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGB9</accession>
    <name>N1PGB9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGB9"/>
    <dbReference type="eggNOG" id="ENOG502SS66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050871_1_0_1"/>
    <dbReference type="OrthoDB" id="5366256at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29732" checksum="AAF9A74D4B87E5C6" modified="2013-06-26" version="1">MSSLGFLLPTQYGSGPGESDPASYTMDQNYIPPMRMSQPATTGGTTAYAQTASSSPSHYQQNRTPDLSSGRRHSEMPTSSSSHAYDQSYRRISSPYDNMSSGPYSMPPSQTIPSISGITQSPLPSPAMNQTSGSQYNSSMSRSPHMYDSNMYSQQPAYTTAPSATQLYAPSQNMSYPPPYGSPNETLSKPISGDSSIRVLNQRPKPQCWEHGCNGRQFSTFSNLLRHQREKSGTSAKSYCPKCGAEFTRTTARNGHLAHDKCTKQRRSSDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH08</accession>
    <name>N1PH08_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_176547</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH08"/>
    <dbReference type="STRING" id="675120.N1PH08"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_7_6_1"/>
    <dbReference type="OMA" id="QPASYCG"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME41419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="390" mass="42339" checksum="435F8B25103B62D7" modified="2013-06-26" version="1">MDEFGMGSHSQYSHFGPVQSPFARDGMPLSPGGSSGGSAVWVASKLCWAALGTDTGGSVRLPAAYLGQVGFKPSYGRLSRWGVIQYANSLDTVGILAQNSEDTRSLYRCLDHFDEQDPTSLPWSLRERIQCISGKRDSSRLRIGIPVEYNIKELSPAVRATYTATLAALQSAGHTLHPVSLPSTRRALSAYYILAPAEASSNLAKYDGIRYGYRTSNTDASPNSTTPLPLYAETRSESFGEEVKRRILLGAYTLSSQAIDNYFIQAQKIRRLVQRDFDRVFALSNPLLDADEGPAGEIDVLLTPTAPTLPPTVAELKRQSPVESYMNDVFTVPASLAGLPAISVSMSLSALHLAEMEDTDVRTAGIQIIGQFGDDEFVLQAAKTLEVLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH17</accession>
    <name>N1PH17_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7871 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_135223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH17"/>
    <dbReference type="eggNOG" id="ENOG502SCEH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133919_0_0_1"/>
    <dbReference type="OMA" id="CTCEKAT"/>
    <dbReference type="OrthoDB" id="4140664at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057193">
        <property type="entry name" value="DUF7871"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620:SF1">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25277">
        <property type="entry name" value="DUF7871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7871" evidence="2">
        <location>
            <begin position="8"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="113" mass="11414" checksum="381A164C50C96D8F" modified="2013-06-26" version="1">MSGPTASVPATCCGKNGTGCVCAQEATCSCGKQSALHCTCEKAQLENKVDGARCSCNQRPAGACTCSRSSTENASPAGSTCACGKRSHDSCNCNNTETGAASSDLETDFTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHX4</accession>
    <name>N1PHX4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_156730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHX4"/>
    <dbReference type="STRING" id="675120.N1PHX4"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043434_0_0_1"/>
    <dbReference type="OMA" id="TNSIHNA"/>
    <dbReference type="OrthoDB" id="2935572at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12261">
        <property type="entry name" value="RRM1_3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="50884" checksum="4E1BFD36D01E6F14" modified="2013-06-26" version="1">MAAIEKVTVDKSYFDALLRRYVFCTLLISMANVQCKHTSAQILERADPASVTISQVEYDSLLRVSREFELLKTSLYQGSLTSETLALLIAGASVPKSQEPVDSWADDFDDQPVIYCQPKLHSNAPVHFTGNPNGMLWRSQTKTGGFNPAPGSGAYKALEQRPSQASLQVPKSSRNISYGYLPSSIPDDTALEADSMMDDANTEMGTSAHNGSVRRTLYFCNLSPKTTYKDLASVVKGGKLLSITIRSERSATVTFLDAAADYLAWTKRNDVYVHARRVEVRWAERQFNLNEHIANKISTGATRNILIRNALGKGLTGERIRDDMEHIHGLVIIDVKYKNGNAWVSTNSIHNALFARTCMMSRTAYRGCKIEFYPDECDVPLPVRAKPPPADLQKPVKKDMPLSNRFDMLHMSSDGSSGSGEENRDALADLHGDPDSGSATDSVHIVPRAGVRLDFLESGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI71</accession>
    <name>N1PI71_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_74025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PI71"/>
    <dbReference type="eggNOG" id="KOG0401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003998_0_0_1"/>
    <dbReference type="OMA" id="PRGGPNM"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="1027"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="822"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="903"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1286"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="403"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="583"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="720"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="752"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="776"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="967"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1423"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1435"/>
            <end position="1444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME41824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1444" mass="152897" checksum="3092089082B1271D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI88</accession>
    <name>N1PI88_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_46734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PI88"/>
    <dbReference type="HOGENOM" id="CLU_2812321_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="67" mass="7814" checksum="0BFE0F28A2768113" modified="2013-06-26" version="1">MAVKGFDDFQVFEELDHLSLGEAWAFHDRSRQNPESGSLLQQRNRSPTAITSRRLVIDEQQCILRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI90</accession>
    <name>N1PI90_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_55117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PI90"/>
    <dbReference type="STRING" id="675120.N1PI90"/>
    <dbReference type="HOGENOM" id="CLU_698346_0_0_1"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="395" mass="44272" checksum="6F6978912F38F65D" modified="2013-06-26" version="1">MSKAPEAASDFTACDLQARGNEFLERNDCFVVCDSDGATVDSISYQVKAVQPLLQLERATTHTGDKCGSSLIDTEFKSWLRDAVGRDKYAERDPVNAKQYRISPITAETGVMKIIITRFNAQKEAFSNLKQGERGRFDYPLLSGVLIQHVAWLTQGRHELKKIMNSCVNDVTKLITYQVNQVGKGKNRRVKSLLLVGGFGVSPYLQQELEKSVARKQPPIAVHRPLPGKSLTAFVHGGVIYGVETSRRTPVKCIAATTKGYETTIWSRVFWHPTKSCAKGKHDFPVYFYLHDDDSLPERSKTGQHEVEPIEAVKADLSGYLDHDPRLHPHHLTPGGAPASDYRSSIGPLKWRFTLSATSIQAELHLKDARIGEYEIKWSATDRRIVRVRARRGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ21</accession>
    <name>N1PJ21_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_54768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ21"/>
    <dbReference type="STRING" id="675120.N1PJ21"/>
    <dbReference type="eggNOG" id="KOG0051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283221_0_0_1"/>
    <dbReference type="OMA" id="IYEMDEG"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="636"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="636"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="689"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="918"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="926"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="948"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="965"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="979"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1008"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1037"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1055"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME42392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1101" mass="123862" checksum="7868F970C9FDC534" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJQ3</accession>
    <name>N1PJQ3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_133285</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJQ3"/>
    <dbReference type="eggNOG" id="ENOG502QQVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054785_2_1_1"/>
    <dbReference type="OMA" id="GRKYARH"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018229">
        <property type="entry name" value="Rhodopsin_retinal_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00950">
        <property type="entry name" value="BACTERIAL_OPSIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00327">
        <property type="entry name" value="BACTERIAL_OPSIN_RET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="285"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME42627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="333" mass="37220" checksum="9C1DCB4738AD867D" modified="2013-06-26" version="1">MSILYARENDAVRDNPPYANGRAADIHITERGSDFYYAICATMGFCGIVFLGCSLTKRRTDRIFFYLTAAINFTACVAYYSMGSNLGFTPIAVEFNPIDSHVHGMNRQVFWVRYVDWFITTPLLLLDLFLTAGLPAPTIFWAIFMNELMIIMGLVGAVTKSGYKWGFFAFGCAAMFMVFYTLLFAGRKYARHLGSDVSLAYLLPTVLLVLIWLCYPICWGVSEGGNIIAPDSEAVYYGVLDFVAKPVFSALLLFFHRKIDPARMGLKFREYDEDFAIMAIQNGHNRHHHDRKDEAPALGEGVRASEAADRPVAGDGTTSTHHDTVHNDATHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJT8</accession>
    <name>N1PJT8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_71567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJT8"/>
    <dbReference type="STRING" id="675120.N1PJT8"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029404_1_0_1"/>
    <dbReference type="OMA" id="FKTEGQW"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000118">
        <property type="entry name" value="Phosphatase 2C-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF24">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="178"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME43772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="413" mass="45515" checksum="02F09DEE9B091F25" modified="2013-06-26" version="1">MLTLRLITSASTIAPRAAKVAAASRCMSTARTFWTLTARHEEAGSSTVISSKKRERSRDPQAGLATPAPDEARDKKSASPFYFSAGYAGWAKRPSRPFPPPFFSPPSGSFSDPLSTHHRSIDRRPKVDGQMIRGVTNGDDAILVSDSLICANDGVGQWAQRERGHAPLWSRLIAHFWALAAERDLYGQVHEEGEGGKGKGEPDMIRYLSVAYERTKEALSEPNEWHGTTTASAALLHWIDGPEGQYPMLYVTQLGDCKILVVRPKKESPGEGDVIFASQEQYHYFDCPRQLGTNSPDTPEENGVLDRVELFEDDLVLAMSDGVTDNLWEEEIADYAAAGLKNYKEKHNDDEGPEAMKYVAQEIVLQARKIAEDPFAASPFMEKAVEEGLAIEGGKIDDISVVVAMCKRRDEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK47</accession>
    <name>N1PK47_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_73355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK47"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022332_0_0_1"/>
    <dbReference type="OMA" id="LFWEVPK"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="40"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME42489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="404" mass="44146" checksum="E07463F61EAD367E" modified="2013-06-26" version="1">MNEKERQSGEQPRDTQEPVLPTINPETKQPEPAKASLHPAFYIATWISLSSSVIIFNKWILDTAGFRYPIVLTTWHLAFATLMTQIMARTTKSLDGRKKVPMTGKIYLRAIMPIGLMFSLSLICGNLTYLYLSVSFIQMLKATTPVAVLIATWIFGVAPPNLKTLGNVSFIVIGVIIASYGEIKFVLTGFLFQVGGIIFEATRLVMVQRLLSSAEFKMDPLVSLYYFAPACAVMNGIVALVVEVPKMSLVDIEKVGYATLLVNAMIAFLLNVSVVFLIGKTSSLVMTLSGVLKDILLVVASMLIFQDPVSGIQAFGYSIALGGLVYYKLGGEKLKEHAGQAQRAWADYGVRHPALRKLLVFALVLITIFALLGGASQSGYVPAQYNPGKLTTDAYKQWAGKTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKE3</accession>
    <name>N1PKE3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_174819</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKE3"/>
    <dbReference type="STRING" id="675120.N1PKE3"/>
    <dbReference type="eggNOG" id="KOG3873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034001_0_0_1"/>
    <dbReference type="OMA" id="IEESSMF"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052714">
        <property type="term" value="F:mannosyl-inositol phosphorylceramide phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000059">
        <property type="entry name" value="Inositol phosphosphingolipids phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="462"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME42030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="493" mass="56375" checksum="A529CEB0A0609B21" modified="2013-06-26" version="1">MTETNTSTPHPILSLPSTLRIVSLNCWGLKFISKFRHERLTEIGRQLTLSHPVPEIVGLQECWTQQDYLQIRELTRHILPYGKFYWSGVFGGGLAILSKWPIEESSMYRYPLNGRPAAFWRGDWYVGKGVACARIRIGPREKEVVEVFCTHLHAPYEREPNDSYICHRTAQAWEIAKLMRHARERGHVVVGLGDFNMVPRSLAHQIVEGHGGGVRDVWRVLYPDSAVGSAESEAERERGNSVPTVRECLELHGATCDSRLNTWRWSKEEQKALTKGRGAKVDVEAEDVKARRLDYIFFADNVAATGHKWEVESVEVGMTMRHPELRCSLSDHFSIETTLVRSPAPQDRRKTTEPLVRHLDPATYQLIHDMITKYDTRERSQRRLQLIHFWASLVVSIGCLTAVWWSPRNYVSFILMLISTLGLSSGVLDGLMGFLFVKTELRALKEFKFDIENAADQARALGERPATQREVAGKMREALREREGEPDHEVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKI1</accession>
    <name>N1PKI1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_156871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKI1"/>
    <dbReference type="HOGENOM" id="CLU_2043620_0_0_1"/>
    <dbReference type="OrthoDB" id="2142503at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13930" checksum="6DC5C22C2D3B8AED" modified="2013-06-26" version="1" fragment="single">MARGKRHKRRASKDLNALPKKAQRAKKTPVKRMAAEIALQNEEILHSIISSLPLLERLVARRIAKHWTNAVNSFSDLHAFPFFEPQDAPHEFIYWGTYDRLNNLGPYITAALYEDDVQAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKN2</accession>
    <name>N1PKN2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_71753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKN2"/>
    <dbReference type="STRING" id="675120.N1PKN2"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034705_1_0_1"/>
    <dbReference type="OMA" id="QRHEGCR"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061852">
        <property type="term" value="C:retrograde transporter complex, Golgi to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="142"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME44052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="436" mass="48097" checksum="9ADE869FCDAEDC7D" modified="2013-06-26" version="1">MPAKSRFTKLDAFTKTVEDARIRTTSGGIVTVTSLLLILYLVWGEWADYRRITVHPELIVDKGRGEKMEIHMNVSFPRVPCELLTLDVMDVSGEVQTGVMHGVNKVRLRPEAEGGGEIEKKALDLGVEEAAQHLDPDYCGECYGAPAPSNAAKPGCCNTCAEVREAYAGVSWSFGRGENVEQCEREHYSEHLDAQRKEGCRIEGGIRVNKVVGNFHFAPGKSFSNGNMHVHDLENFFNSPEGIQHTFTHKIHSLRFGPQLPDDVVNKVGKRGIAWSEHHLNPLDGTSQVTEEKSYNFMYFVKVVSTAYLPLAWKPSGSLLDLPHELVELGGYGKGEGGSIETHQYSVTSHKRSLQGGDANEEGHKERLHARGGIPGVFFSYDISPMKVVNREARTKTFTGFLTGVAAVIGGTLTVAAAVDRLMYEGGQRVRKYHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKR5</accession>
    <name>N1PKR5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_55599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKR5"/>
    <dbReference type="eggNOG" id="ENOG502R0US">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_588161_0_0_1"/>
    <dbReference type="OMA" id="EYLQNCH"/>
    <dbReference type="OrthoDB" id="3637419at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="53488" checksum="5CAA032E9892F278" modified="2013-06-26" version="1">MFSALPVELIEHILAFLHHDDNQTYAAVCRVNRLFHEIGTPRLYRSINVASFDHDERLHRLQLLIRTLSENLPLTKHVEEISQYVWRDSTLERPIDVDIEVETLQELLRRDLAVPFIVIDYLDLIEGHISEDCGLLILIGICPGVETLNLLGELNHLKYWHDFSQVITEVRHFEDVVSEGSLRTANGATPSTGTSFDTISTVNLKCSGGGELHTDIEDLESLLWLPALQRLHTDVFDRRSEPGPYHSPPNLMSRIETLEIENCGANGEDFHDLLPYCPALKILNIEWPSRGDNYRRFDWADLGNCIRENCPNLQTLLLDHPRDSMLDDDAYRNVVGDMNDEYLQNCHLPGLGSMRSLQQLQSYHVSNIALFGTHRDDSFVPADFSDSDDENEVKHCLENVLPESLNELSVLCEHQGLEHVDIAILHEAGAERLELLTIMDCQKDEWISRNHGQLTASTPELLARVEQGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL17</accession>
    <name>N1PL17_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_45580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL17"/>
    <dbReference type="HOGENOM" id="CLU_1586440_0_0_1"/>
    <dbReference type="OrthoDB" id="5390937at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="168" mass="18288" checksum="7455C63BB1B5B53D" modified="2013-06-26" version="1">MLNLASMPRCQTTISKYHITKNGTSIDLNITQPGAVISKTSITAGVYNGMVSFTQVEEKVRSNSTVVSTMNFVSSLEDIRNPNITTAPARGYYHAYFAGTVSSIFGYVNGTQGATHILGNIDKTTVSDPLFPAQWASFRREFPEFFDNSTGHVSPNWTQILGDAGLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL60</accession>
    <name>N1PL60_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL60"/>
    <dbReference type="STRING" id="675120.N1PL60"/>
    <dbReference type="eggNOG" id="ENOG502QTVK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033074_1_1_1"/>
    <dbReference type="OMA" id="EPLAHIC"/>
    <dbReference type="OrthoDB" id="5317787at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="486" mass="55003" checksum="903C59CFD45DBFA2" modified="2013-06-26" version="1">MVLHHSLECEDIRSAFSGSMAPSDRAFHSDRGSHRSYPPSHTSSDESSHSTQPTVYSGTSERRPPRVHYNTCDDYHAAPSTTRYCPEQAPHESPRASVETYASTIPSEEDLPQELPEYEVPEYTARPYQSAAIAATPSDFSELFPSHRRMAIRHDDATLDGNMNLRVDTEVTVHGGRRCDMTLFHLRMHDLRDREFSLRRYCRDSGREVCHSSRRQQNSAAPKRPSFQRSLSNALSSMRPKSEQRSPTMASLKRNDSGYESVHSSIDMDRDEYVQTSYSSMTTQQAVERNIVKLEFSNYAQLDVRRAGNKANKRYEFEYWGTHYAWRRVVKKDNPLKQFSYHLVKSGREDVLAYIIPSPLTPGQAEEEQSKGGWIPPCSMWIADDSIVGGQKDVADVVIATGLMALVDDNIKARFHVRDSKQLLIPKLQTGMEYIGPKRLINEMFKREGTSQHSRQPSSSSRPSSSAGLTSASGTRAVVRQSSNNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL97</accession>
    <name>N1PL97_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_34755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL97"/>
    <dbReference type="HOGENOM" id="CLU_1547548_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="173" mass="19300" checksum="37D4BFFD66634210" modified="2013-06-26" version="1">MLAALGTCPSRIPRHGHGARVRIHRSILIIFCMDARRGVFEIESAKGGGQAVRVLQVARWRGDAGRPQKPKNNVGTAAREVVAATRAKSQQAQLFRFPTQEARSGRCRCRCTQSSRLEREVCPLFSNHYYCTSTTSEEDVDDNDNDKDDDDDDDDEADDDVDDDDDDDAQELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLB0</accession>
    <name>N1PLB0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_71790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLB0"/>
    <dbReference type="STRING" id="675120.N1PLB0"/>
    <dbReference type="eggNOG" id="KOG1827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012767_0_0_1"/>
    <dbReference type="OMA" id="LWTNAYF"/>
    <dbReference type="OrthoDB" id="6017at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000083">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054551">
        <property type="entry name" value="RSC4_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22994">
        <property type="entry name" value="RSC4_Ig_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="59"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="255"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="411"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME44106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="665" mass="73156" checksum="C2B15088F512D924" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLH1</accession>
    <name>N1PLH1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLH1"/>
    <dbReference type="STRING" id="675120.N1PLH1"/>
    <dbReference type="eggNOG" id="ENOG502S0AG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033002_0_0_1"/>
    <dbReference type="OMA" id="CGIRKIW"/>
    <dbReference type="OrthoDB" id="552755at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037647">
        <property type="entry name" value="HIRIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="423" mass="46752" checksum="50E04D829B259EF8" modified="2013-06-26" version="1">MSDSELSEATSVPTATAIEAALKRAVRDIEKTGEDVTINNARRLAEEALDLDEGFLKEADWKAKSKDIITLAVHQDEKPESPKVPTKPASKPKSKASAKASRKRKSDDDEDDEQAAKPPRRRKAAKVESEGEESDPEAGDDKSAFEEEEEVKPKKKQAKKPVKKPAPKKRKKVAEVVHSGDEEEPEVEAASRKSSHKVKREHEDDEPAEDNKPAADDTSELSDVPDKISEEPTKANGKSAAPEDDDSDMSVLIDEPPKKKRQKKTETGSKAKSTAREAKAKATKAKPAKKELSADEEEIKRLQGWLVKCGLRKMWHRELANCSTDKAKIKHLKDMLDDAGMTVRYSNEKAQKIKDQRELAAELEAVKEYDEKWGQSEGDDNGKDEDDDVGNEKAGETKGDEPPKRRLPKGLIDFGDSGDDGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLH5</accession>
    <name>N1PLH5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_24265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLH5"/>
    <dbReference type="HOGENOM" id="CLU_2209954_0_0_1"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11479" checksum="6101B8EF4DA06476" modified="2013-06-26" version="1">MALAPGEKLVGRGASPLGENDCDAALLAPPIHSGMSMATRYADSEVTVVEKPQAAVMASQPAPVIQPAYVAASVTPLRHLKKEPAYVDCPHCHERRLTRVTKYEEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLS9</accession>
    <name>N1PLS9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_73377</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLS9"/>
    <dbReference type="STRING" id="675120.N1PLS9"/>
    <dbReference type="eggNOG" id="KOG2499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007082_0_2_1"/>
    <dbReference type="OMA" id="GHDVVMC"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF58">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108878" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="18"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="182"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME42510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="573" mass="63973" checksum="7CEBE73D37A1D5B6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLZ4</accession>
    <name>N1PLZ4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_152208</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLZ4"/>
    <dbReference type="STRING" id="675120.N1PLZ4"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014490_0_0_1"/>
    <dbReference type="OMA" id="SFQGHRR"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000146">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000239">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="168"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="304"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="676"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="325"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="720"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME44371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="763" mass="82740" checksum="DC0F6202F9AB0859" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM16</accession>
    <name>N1PM16_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_80148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM16"/>
    <dbReference type="HOGENOM" id="CLU_490032_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="556" mass="60146" checksum="9A4C57547796DF1D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM32</accession>
    <name>N1PM32_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_107644</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM32"/>
    <dbReference type="STRING" id="675120.N1PM32"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002678_42_25_1"/>
    <dbReference type="OMA" id="FTRREHY"/>
    <dbReference type="OrthoDB" id="3946596at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME44411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="54" mass="6589" checksum="09AC3BA19B91AB42" modified="2013-06-26" version="1" fragment="single">EQKWQCEHCPKAFTRREHYKRHLLLHSGTRPFACPGCPKTFYRKDMLQRHLPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN77</accession>
    <name>N1PN77_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN77"/>
    <dbReference type="STRING" id="675120.N1PN77"/>
    <dbReference type="eggNOG" id="ENOG502QW4G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035426_1_0_1"/>
    <dbReference type="OMA" id="YYDNQQW"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="399" mass="41983" checksum="8E313268F0968DDC" modified="2013-06-26" version="1">MSYFENDNGSWSGSGRQASWEHPAPPSRTGTGSAMSTLPESTAFASQFEEIDRATDNLMKSGKWVPGAAQGAVGAGNAPPRRDSMPAMARGYDYNADPRLIGGPSRHQSVSEFSSEGARPGSAGLQGFYAGQRFPGGRQSEAEQVLQTKRKMAAQRERELRNYHQEQQYNRTVSGVKTDRSMSPNTMSEDDRRDLIARQHRALYGDNSSLYSADGSRRGSQDIRAPSGARGPSPLAYDPFSAQAQSGAEGVVQMPPRDRPENNASPASNAPAQQPSFGLLNEPQQQSRATSNSSQGGSPPISGQQKGSISGVMPIGTRPAQAPGAAPGLSKRSTTPLTPSSLSFGFNAGDAQNTTKDERSNSAASNAALGSSGLGNWGSNSANWGSGKSTLAVQPSVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNM5</accession>
    <name>N1PNM5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_33623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNM5"/>
    <dbReference type="STRING" id="675120.N1PNM5"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="OMA" id="AHRCEIT"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF96">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109494" evidence="8">
        <location>
            <begin position="18"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME45021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="494" mass="54747" checksum="FA31D8B5C372A8C9" modified="2013-06-26" version="1">MALTTANLLAFLAVLAAVRISATIFQALRNPLNRVPGPWLAKFSNLPLKLAVITGKRVYYIQTQHERYGPYVRISPNEIAVNDPKGFKQIHGINSGFEKSDWYKKLTVMPRPCLFDMTDAKDHAARRRLFARGFSKSNVHQNWGPVIQEKIQLVVSQMIAEAARTRGPVDVMKWWTLMASDVSAHLMFGESFHVIERGEANEYIKTLTSALKGSGIGVELPFVRAIGKLLPFQATKELFCTTEVLDDYAKTAVRNMRASDVAHNIFASIQAESEKGETLDDRTVESEAMGLFVAGTDTTAVSLTYLTWVVLARPQLRMDIEREVGGLPVDFEDQDVEKLPLLNAVIQETLRLYGAVPGGLPRTVPHGGIDMDGYYLPQGSIVSTHAYSMHRDPALFPDPEEFQPSRWLPNSEEHLRVSDAAKAVFSPFGSGSRGCLGLHIAYSELRLSAAEFFRRCRGSGLAPSTTEDSMDMENFFIIAPKSHRCDVVLGEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNW3</accession>
    <name>N1PNW3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_52473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNW3"/>
    <dbReference type="STRING" id="675120.N1PNW3"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="OMA" id="PETWQPK"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME45102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="60042" checksum="3E62C5A0B771FCD4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP04</accession>
    <name>N1PP04_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_70988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP04"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_7_1_1"/>
    <dbReference type="OMA" id="WNTGGCT"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME45127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="65253" checksum="E0C5A3FE50F1D0D4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP75</accession>
    <name>N1PP75_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_71924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP75"/>
    <dbReference type="STRING" id="675120.N1PP75"/>
    <dbReference type="MEROPS" id="A01.080"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_0_2_1"/>
    <dbReference type="OMA" id="WYGGVQS"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000092">
        <property type="entry name" value="Aspartic endopeptidase (AP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME44244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="447" mass="47186" checksum="1EAEDAC26F1F4D01" modified="2013-06-26" version="1">MASKSNLVRGALKRNPAHKRNGLRSYVHAMEKWGFGPTLKGPYCRVNHVHQQGQQAVFKATGRRVGGRAHVKGHVLAKTDQSGQTGDVPAEDVENNAEYLATVGIGTPAQNLALDFDTGSADLWVWSTELPANIRNQSGGNSHTIFDASKSSTFKKTSGSTWQIQYGDGSTASGDVGTDNVNAGGLVVQNQAIELAKTLSAQFEQGPGDGLLGLAFGSINTVQPTPVNTLVENMIAQNDIEKPSELFTAYLGSTAIGGSSSGSSSSAADDSTSFYTFGYVDDQATDGQTPAYTAVDNSQGFWMFDSTSAKVGDQTVTRSGNTAIADTGTTLALVGDDVCQAVYGAIPGAKQNTQQQGWVFPTSTDLSTLPQVQFAVGDTLFTINPEELPFQDLGDGTYYGGIQSRGDQNFDIFGDVFLRSVYAIFDQGNQRFGATQRASTLSSASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPJ8</accession>
    <name>N1PPJ8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_52298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPJ8"/>
    <dbReference type="HOGENOM" id="CLU_478190_0_0_1"/>
    <dbReference type="OMA" id="CWRCEMA"/>
    <dbReference type="OrthoDB" id="3650891at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="570" mass="60871" checksum="6AEB265A3E7EE50E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPK4</accession>
    <name>N1PPK4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_172526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPK4"/>
    <dbReference type="STRING" id="675120.N1PPK4"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OMA" id="PNSSFWY"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="450"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME44364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="563" mass="62746" checksum="8F6104174380232C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPX9</accession>
    <name>N1PPX9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_62006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPX9"/>
    <dbReference type="STRING" id="675120.N1PPX9"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME45486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="462" mass="51042" checksum="ED075B0583E329AD" modified="2013-06-26" version="1">MPRKSSSSHESPRDRPLTSTIPESTWCAAKEDSEIHAYAHAPNNRITKAEARDLERHIAYVLRHRHGIGSRGPGKDVVLSVASLDPFLPIVFYGIVAAGAPPLPISELTRQIRDSGTTLVLYSKEYEEATVAAAKECNIPPDRVLVIDSSSPIRMFEWPRLTSIAELERITTCLLYSSGTTGLPKGVHLSHWNLVSSNVISMRVGARYIARRMQEGHHFEWRTMECLPMAHIAGIQQSSLNPFYMGGTVYWMEKYNFRDFIMYSRQYRTVYQFSVPPIWLQVAKSPEVTDHFDSLEVASSGAAPMGLELVKEVSQELGKGDTFMTQTWGATETDGSTTATDWDSRDETGTVGRILPNVKLRVVDDEGQDVEPGEAGELLVVGPLVCQGHHNTAASIVNGWFVAADVDNIKNHLIADAAVIGMQSERYGTEVPKAFIVATAGESLAVEEVMEFAKNTLASHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQF4</accession>
    <name>N1PQF4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_71038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQF4"/>
    <dbReference type="STRING" id="675120.N1PQF4"/>
    <dbReference type="eggNOG" id="ENOG502SRV3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057752_5_2_1"/>
    <dbReference type="OMA" id="FYHMDYL"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="292" mass="32629" checksum="04E1682B780B2259" modified="2013-06-26" version="1">MALSPNTTREPSAQKELMSALSALHLGGKYSDLTITCGYRQWAVHRAIVCSRSGFFDGACSHRFRESNTGVIDLSEDDEEAVAQMIHYLYHLDYLNEQPAQQPSAMFRHRAYSNARKKAAKKLDLTQIQDPLLAQAGVYNAPDEPAAQSTVEPGKTSRSAAEARSGTPPLETDLGSDEELREEHELTESESHLVLHTQIYALAEKYDIPALKQLARHKFEMSAACYYDAPELADAIEFVYSSTMDSDRGLRDVVLQLFRSHPQLANTQDIFAVLKETPTLALELWKVERGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRW6</accession>
    <name>N1PRW6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_51751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PRW6"/>
    <dbReference type="eggNOG" id="ENOG502QRX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002983_1_0_1"/>
    <dbReference type="OMA" id="ETIHYTL"/>
    <dbReference type="OrthoDB" id="5382203at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1341"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1347"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1369"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1433"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1449"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1485"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1498"/>
            <end position="1507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1507" mass="163415" checksum="3F4B6FE42A7CED64" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS62</accession>
    <name>N1PS62_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">trans-L-3-hydroxyproline dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_52545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57938"/>
            <dbReference type="EC" id="4.2.1.77"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proline racemase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.77" evidence="3"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS62"/>
    <dbReference type="STRING" id="675120.N1PS62"/>
    <dbReference type="eggNOG" id="ENOG502QRPF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036729_0_1_1"/>
    <dbReference type="OMA" id="SHVLWTG"/>
    <dbReference type="OrthoDB" id="6409228at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050346">
        <property type="term" value="F:trans-L-3-hydroxyproline dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.10:FF:000003">
        <property type="entry name" value="Proline racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442:SF1">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="394" mass="42743" checksum="6C15503EACE88CEE" modified="2013-06-26" version="1">MDIAKDFTSTSRKDAITCVDMHTTGEPTRIVVSGHPELTGTLLEQRAEARRSYDHFRRQLFLEPRGHSDMYGAILRQNTEHTASGNAHIGVLFATNSGYSTMCGHATIALGRFLLDTHDKTAFPNRDKVTLNTTTKTASLTLHAPCGIVHVTVPTNDNGTRSDPSRPVSHISVPSFTTGLNIKVPLPDPYRWPELADCQHVTVDFSYGGTFYCFITATELGFPRGLVGKIDVQAMNVATRNLKAAINKNADLQHLFSHPDHDELSFLYSVIIVDKDAGIPIAQSTTAETGLCFFSDQQVDRSPTGSGVAARIALARAKAELDKGEPATYHSRLSNSLGGRGGFIGSLHEEIGVKDGFPVVRAKVEGYASYTGTSTFVVEDGDALGQDGFLFDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSH1</accession>
    <name>N1PSH1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-releasing factor 2, mitochondrial</fullName>
            <shortName evidence="5">RRF2mt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor G 2, mitochondrial</fullName>
            <shortName evidence="5">EF-G2mt</shortName>
            <shortName evidence="5">mEF-G 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MEF2</name>
        <name evidence="7" type="ORF">DOTSEDRAFT_71143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSH1"/>
    <dbReference type="STRING" id="675120.N1PSH1"/>
    <dbReference type="eggNOG" id="KOG0465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_1"/>
    <dbReference type="OMA" id="GPQFTFP"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051881">
        <property type="term" value="P:regulation of mitochondrial membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000106">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000007">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03059">
        <property type="entry name" value="mEF_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030851">
        <property type="entry name" value="EFG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="47"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="139"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="193"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME45315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="881" mass="95446" checksum="0932405605D9ED2B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSL0</accession>
    <name>N1PSL0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_71176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSL0"/>
    <dbReference type="STRING" id="675120.N1PSL0"/>
    <dbReference type="eggNOG" id="ENOG502SP7J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007003_8_1_1"/>
    <dbReference type="OMA" id="DHGPVVW"/>
    <dbReference type="OrthoDB" id="3648506at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="404" mass="44833" checksum="CFAB1B895702FD86" modified="2013-06-26" version="1">MDQAAVEDSRGRAAVLLASVQKAKRQAVVGACERCRSKKIKCDGERPCSTCKKKSIQCIFEVEENESHQEARKRKFEEISQAYSEAQDLLAAMANSDERTARELFNGIRKGQTAASIMRDCQTYSQQQSAGLGNQQRKKLFIMAVVQSTLALREVIGVGISILEGSSHILLPQQDAYESIRDTVIHLESIGQLLRDANPHATLLLLGGLPEYNLCRVPRAIGDGLDHGPVVWVETAPWVDLSIGNHATSHLISIFLRIHNPFWRCVEEDLFVKAMRSGQLDSGFCSPLLVNAILALASQHSEIDEAFFTPGELLTRGEHFHREALRLWALEEGLASLTNIQALLLLSIESGVRGNDKLGNQLVEKAYTLHKMLPIPDIDHNAGSAARDYCRARRVIAWTSVYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSS2</accession>
    <name>N1PSS2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_86988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSS2"/>
    <dbReference type="eggNOG" id="ENOG502QTPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079935_0_0_1"/>
    <dbReference type="OMA" id="QVEEYGW"/>
    <dbReference type="OrthoDB" id="409121at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017771">
        <property type="entry name" value="Cyanamide_hydratase_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03401">
        <property type="entry name" value="cyanamide_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="61"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="239" mass="27237" checksum="F2A301DC6F072322" modified="2013-06-26" version="1">MSKPHQVEYGWTAVPRGRSNVPSEQKARTTNVGVDFDSIWPQTQVVKGAQAYVKEKLPEETYNHSLRVYCYGHTIVSQHFPFWIEQARDQFFETWALTCLFHDIATTEENRDATWLSFEFQGGFIALQQLRLYGAPASQAESVCESIIRHQDPGETGTISRMGQLVQIATEFDNMGWQPYLVDNGVVEQVVKQLPRQKWSSCFAQSIQNEIDAKPWCHTTAIPGFKEAVAGNKLMEPYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTY4</accession>
    <name>N1PTY4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_168976</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTY4"/>
    <dbReference type="STRING" id="675120.N1PTY4"/>
    <dbReference type="eggNOG" id="KOG2869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023334_3_1_1"/>
    <dbReference type="OMA" id="DDLWHLK"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="380"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME46408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="415" mass="46229" checksum="815DA6AAC20C9617" modified="2013-06-26" version="1">MKLIKSNIERKTGAGSATLLPEEPEDMWHAYNLIRPTDLLRASAIRKVISESTTSRSSERVQMTLTIRVTKLDFDPQAGQLHVSGQVAEENKYVKLGGFHTLDLELHRNFTLEKADGWDSIALDTLKEAINQDAKAQLWAVVMQEGLANICLITEHQSILRQKVEVSLPKKRAGSSDHDKAVQRFYQTTFDSLLRQIDLTDPRPLLLASPGFTASSFQQFIRIQASTGTNKPLQQLVPKITVAHSASGHLHSLNEVLSSPAVTSKLSDTKFARETQLMERFFEMMRQDDARAWYGPKECEVAIERGAVGKGGGILLISNALFRSQDIKTRRRWVKVVDDVKEQGGEVRVLSSMHESGKRLEGLGGIAAILTYPIEDLVEEAPDDEGEDSLADTMYDDASDGIEGRRGPYEEDIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUA0</accession>
    <name>N1PUA0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Heat shock protein Hsp88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_41556</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUA0"/>
    <dbReference type="STRING" id="675120.N1PUA0"/>
    <dbReference type="eggNOG" id="KOG0103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_5_1_1"/>
    <dbReference type="OMA" id="WEQSPEI"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="655"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="662"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="721"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME47036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="735" mass="81557" checksum="2EE17C5ADCFBB728" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVE4</accession>
    <name>N1PVE4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_60980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVE4"/>
    <dbReference type="eggNOG" id="ENOG502SEZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183460_0_0_1"/>
    <dbReference type="OMA" id="WPASIFC"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34673">
        <property type="entry name" value="COLD-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34673:SF1">
        <property type="entry name" value="COLD-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="78" mass="7903" checksum="3FB55D890A3C494B" modified="2013-06-26" version="1">MADCGFLPLPLCIQCGTDQNPCHVKVVGPTLGFAVGVVMAVVCWPASIFCGCCATDTGKRMLGAPADTSGAVSNAIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWT1</accession>
    <name>N1PWT1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_70616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWT1"/>
    <dbReference type="STRING" id="675120.N1PWT1"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_13_0_1"/>
    <dbReference type="OMA" id="GWLIWRD"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="95"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25000" checksum="DF39830003B48EB0" modified="2013-06-26" version="1">MPDKDASSPRVFLLRHGETEWSKSGQFTGVSDIPLTSHGENQVKATGQMVYGPGKLIDPKKVAKAWVSPRTRAIETYELLTGSKEGYEVSESLAEWGYGQYEGLKTQQIRDLRKEHGLDRESAWDIWRDGCEDGETPEQVTARVDALIAQIRGLQALHMKDDEPKDVILIAHGHLTRAFAKRWLGYEMSFPLSLMMEPGGVGVLSYQHHSIDEPALLLGIGFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWT7</accession>
    <name>N1PWT7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_125148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWT7"/>
    <dbReference type="eggNOG" id="ENOG502TE07">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_806592_0_0_1"/>
    <dbReference type="OMA" id="PLHRRWN"/>
    <dbReference type="OrthoDB" id="5383839at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="344" mass="38037" checksum="AAA788ADFC322A5F" modified="2013-06-26" version="1">MSPLHRRWNSKATPSTSTSNMCSPLVNRTNTQKSAYSTTTAATGATGMSNTTFLPEFHSTPPMPTLQKPHSAITGTPTPLRTNTTSCSMAGYDTTPTENIFLLRQKSASGCSHHRSASPRTRRCKATIDVRDRLPNTPELPEKWSPLHDRAMCILDTRGYTHEAIVKKLKSTFVELQEKCLTPVMIDKQLRILDQKPEIPYWRVGLATLTSAEEEKEEEKKKKKKGQGRALTPKTAGSTGDNQSPSELPRRSTEAVSASSATKNSTRSLSKISRKDTESALHGKDSTQDLYVLMAHMEAKELAKTATQHQEEQENWKPHGPRAKGSTNSLRMRQPLAQISSGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXB3</accession>
    <name>N1PXB3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate esterase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_107757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXB3"/>
    <dbReference type="STRING" id="675120.N1PXB3"/>
    <dbReference type="eggNOG" id="ENOG502SQ4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040058_4_2_1"/>
    <dbReference type="OMA" id="NEWSGHT"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="199" mass="20671" checksum="876826E92DA0FA83" modified="2013-06-26" version="1" fragment="single">GAHIIVARASLEVLGYGIIGAVKDNVLKAVPGSTAEYVVYPATLTDYFNSESDGVVAMRKLIDAYVAKCANAPLVLMGYSQGAQVTADSLVGQQVVAFPANSSVDQPLPDSTLQSVAAVVMMGDPSSNLTESFHVGNATKNGIFPRKNVASFADTGLASRAKSYCDAGDPYCASGNFSMLSVHLGYVQEYGSAATTFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY52</accession>
    <name>N1PY52_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_20918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY52"/>
    <dbReference type="STRING" id="675120.N1PY52"/>
    <dbReference type="eggNOG" id="ENOG502RXPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2026677_0_0_1"/>
    <dbReference type="OrthoDB" id="2562743at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="122" mass="13573" checksum="01FFFA4FE52622E5" modified="2013-06-26" version="1">MSRLTLALTANADKNIRLLSTLAATDYAPPSLKQNIGYISDLERQIASTDDKLSRLHIITEDERKVLKEQMGEQQHRLRAREGEVTKVGNVLEEARKGLQRVRAEAFGTGSGRGREVPPAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYL7</accession>
    <name>N1PYL7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_69305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYL7"/>
    <dbReference type="STRING" id="675120.N1PYL7"/>
    <dbReference type="eggNOG" id="KOG2343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011757_0_0_1"/>
    <dbReference type="OMA" id="NNWIHER"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="5">
        <location>
            <begin position="77"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="6">
        <location>
            <begin position="369"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME47329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="806" mass="91730" checksum="907602AE939A9351" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYT1</accession>
    <name>N1PYT1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_118922</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYT1"/>
    <dbReference type="STRING" id="675120.N1PYT1"/>
    <dbReference type="eggNOG" id="ENOG502RZAX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018004_1_0_1"/>
    <dbReference type="OMA" id="ECKNEAR"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="141"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME48666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="421" mass="47109" checksum="E133A7D17E54AF93" modified="2013-06-26" version="1">MTASEATDGRPPLKRGPDPESFVERPAKRGRSRKYPERPSWAQLHPSNPRSREPGVAPNSREGPAPASRHQQPPLSHANTREDSSQATQQSNGQPPPQMNGAGAKPWLRNPPLDDELILARQVLGLPWERSIKWVKPVSGVSRAVADWLFLNFRENADIGRDARVGAIEIEAKLGTLLNDRNERIRLPVRNACVLQPDFPVTFQSSMNANEHRHMNAFLNEATKDATSEPGRQKLHYKHTKETDSFLPLSKAGYDLLPDAAYRNAHRPRAREPSLRTSTNNADGSVVARIVKVKIADDLHVYGAGEPYDVRISMNLEVNFMGKDIDPCALHDDSNPNKNKPNRVKDRMSYRHLNNTFLIDLTRVDSPGMDPIYELELELNANVARDQYALLTEGRQSAYMPVVEGFVDNLALLMKQARGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYW1</accession>
    <name>N1PYW1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ADP-ribosylation factor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_60019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYW1"/>
    <dbReference type="STRING" id="675120.N1PYW1"/>
    <dbReference type="eggNOG" id="KOG0076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_7_0_1"/>
    <dbReference type="OMA" id="HGFYKYM"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001317">
        <property type="entry name" value="Putative ADP-ribosylation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME47585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24755" checksum="479C01EEEC91B677" modified="2013-06-26" version="1">MYHLVKSLYLHATSKEEYSILLLGLDNAGKTTLLEQIKSLNNDAHRPNLNTVPTVGQNLSVIDLPELYLRVWDVGGQHSLRNLWQSYYSSCHAIVFVIDSTDIGDADIERLSKGNVSEDEEGRLDECRMVLEDVLQNEETEGVPILVLANKQDRENCVEVVRIKEGLVRKVFEGEKGQNVRDSRVLPLSALTGTGVREAVDWLCSRVKWNKEARPPVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZQ2</accession>
    <name>N1PZQ2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_67840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZQ2"/>
    <dbReference type="STRING" id="675120.N1PZQ2"/>
    <dbReference type="eggNOG" id="ENOG502SB6R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017895_0_0_1"/>
    <dbReference type="OMA" id="HPECGKT"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="322"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="438"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME48912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="615" mass="68580" checksum="125E11809D4D122A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZQ6</accession>
    <name>N1PZQ6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycosyltransferase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_69594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZQ6"/>
    <dbReference type="STRING" id="675120.N1PZQ6"/>
    <dbReference type="eggNOG" id="ENOG502S4MX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021103_0_0_1"/>
    <dbReference type="OMA" id="NGWAGKP"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="461"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME47689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="593" mass="67798" checksum="A009E85029F622DF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q154</accession>
    <name>N1Q154_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_69969</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q154"/>
    <dbReference type="STRING" id="675120.N1Q154"/>
    <dbReference type="eggNOG" id="KOG0087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_0_1"/>
    <dbReference type="OMA" id="ITAIYQM"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME48194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="212" mass="23362" checksum="CC58C8EA492F8BF6" modified="2013-06-26" version="1">MANDEYDFLFKVVLIGDSGVGKSNLLSRFTRNEFNLDSKSTIGVEFATRSIQVDNKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDISKHNTYENVTRWLKELRDHADTNIVIMLVGNKSDLRHLRAVPTEEAKQFASENGLSFIETSALDASNVELAFQNELTEIYRIVSSKALDQGEQTAGPSQGSAIPLSSSTPPGDATKKGQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1L3</accession>
    <name>N1Q1L3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_58394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1L3"/>
    <dbReference type="STRING" id="675120.N1Q1L3"/>
    <dbReference type="eggNOG" id="KOG2574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026337_2_0_1"/>
    <dbReference type="OMA" id="IGNGPMD"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="278"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME49138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="616" mass="65724" checksum="D26CD40B4A92F3EA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1P3</accession>
    <name>N1Q1P3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_142882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1P3"/>
    <dbReference type="HOGENOM" id="CLU_1111372_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="250" mass="29418" checksum="616FC5A1EE69858C" modified="2013-06-26" version="1">MQKQKELLSFAIRAAGKAKQDLSNGVNDPDSRSRRLLDSYFQCLRLRFEAARNFEEVLREQMYHVKSLISDVNKMEETLEAMQSIKQEFSASPRSILEEESFDMEKATEQVYFAFYTMVRKAEEIDDRLDEIAEREREADELEQGLDEREEELDSWENDLQAREKAMADREDRLARSRQRLKRCRPDRPNAQQAPKEFDKEESWEGEWARALPWHQDSPPRDLVGSWLRQNAIMAESVIHGRSPLSTVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1X4</accession>
    <name>N1Q1X4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1X4"/>
    <dbReference type="HOGENOM" id="CLU_2372771_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="95" mass="10474" checksum="94A74CB0CD7168BF" modified="2013-06-26" version="1">MDSFIAPQECETRPHFRAPPPCNVDSNQLAWDIEKYGARFPATATESHHCLHLSLFSATGNKATNPQQSLLPGRKPKYNRPQSDCAATSAGYART</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3G9</accession>
    <name>N1Q3G9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_145132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3G9"/>
    <dbReference type="STRING" id="675120.N1Q3G9"/>
    <dbReference type="eggNOG" id="KOG1491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037276_1_0_1"/>
    <dbReference type="OMA" id="WILGNLM"/>
    <dbReference type="OrthoDB" id="545683at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.470:FF:000001">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME50336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="436" mass="47264" checksum="74E367E98175426E" modified="2013-06-26" version="1">MPRDPLIGLVGKPSSGKSTTLNSLTDTTAKVGNFPFTTIDPNRAIGYLHIECACSRTSLPGNQPPSPDEPPPLQSRCKPNYGVCQKGTRSVPIELLDVAGLVPGAHQGKGLGNKFLDDLRHADALIHVVDVSGTIDAEGKATRGYDPHQDIAWLRSEIVNWILGNLMQKWGGIKRRHTAVKATPVETLSGQFSGYGANPTVVARTLDKTGLKIPLQDWDNDTIKFVVETFVDEKFPTVLALNKIDHADADKNVSKIAKAEKPERIVLCSAISEVFLRRLVKQGFVKYIPGSEFLDTREDLIEQGEEDGGGLKEMDEKLKTRIENLKDMVLYRFGSTGVNQVLTRASELLGLTPVWLVRNIGTFGSGEAGNAAGDRAAVFRDCVLVKKGSTVGDVYRKVMGDAPLAYSETVGGVRVAEDDLVSTGKNDILSFKVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3L7</accession>
    <name>N1Q3L7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_68574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3L7"/>
    <dbReference type="STRING" id="675120.N1Q3L7"/>
    <dbReference type="eggNOG" id="KOG1560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044094_1_0_1"/>
    <dbReference type="OMA" id="WYQSTYF"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000052">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="14"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="372" mass="41629" checksum="BD73D98C78B6562B" modified="2013-06-26" version="1">MAEISIKDTPIAEVRIEALVVMRIIKHSSQTFPTPTTGFLVGMDSGSQLQVTNSFPYPAAVGEAQTSTDPYHQQDAAALAAAAPRAKSNVAYQAEMIKFLREVNTDAQNVGWYISTSMGSFVNQNFIENQSFFQRATDEKTVALVFDVSRSSQGSLSLKAYRLSPSFMTAYKEGKFTTESIQKSKLRYQDILVELPLRVHNSHLLTAFLHQLPQQPPQKSELEFPSSLAELSRDPSVASTPLAPNLETLDLSIDPFLEKTCDLLLESIENHQTENNNAQYYQRSMAREQAKIQQWQQKRKAENALRAQQKQPPLPEDEWQKLFKLPQEPSRLESLLVGRQVEQYARQVDGFSAVVSAKMFGVKGSLLPGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3M8</accession>
    <name>N1Q3M8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_122098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3M8"/>
    <dbReference type="STRING" id="675120.N1Q3M8"/>
    <dbReference type="eggNOG" id="KOG3764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1318191_0_0_1"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109860" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME50292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="19837" checksum="8811B81026C9BA0B" modified="2013-06-26" version="1" fragment="single">FGRSSQCAGLLYIAFVLPSFGSPLVGACVDRYGGRWIAATGFLLSPAVLVCLRFVNENNLQDRVLLAALLCLLGCLLGTTISVFCAEVSRTVADIEHRRPGCCGSNGIVAQAQGLWWATYTLGVTVGLLWGGFVQRVAGWSTMPWSLALLGGITAIPVATFTSGILWEVSRDSSPGGTRLRSDSSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q475</accession>
    <name>N1Q475_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_20451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q475"/>
    <dbReference type="eggNOG" id="ENOG502RHG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1069666_0_0_1"/>
    <dbReference type="OrthoDB" id="3881872at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME50063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="260" mass="29245" checksum="41865230A877DF6A" modified="2013-06-26" version="1">MSGMSSMSKPGKLARRLFHSKYSILNNVKEENEDITAETKKAAVLTPTTPVNKGPHFTQVINDHYAKALRKGPERSRLTARTSQLQNDQGKVAKLGNRNGVKYELGRPNSTLDHNVPYDMQLPGKIFPAAIATHCPITSTVYEVNMYSFGDTGLYEGPEKERGEYINIMPHGMEEKDDYTPHNPNVPILKIAAKFGRRDMRRTTMAVRVNKISTRITDRDELELCGELDKKSLDILIAEIAKAQGFEVPQWKDEGEETVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4W4</accession>
    <name>N1Q4W4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_31087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4W4"/>
    <dbReference type="STRING" id="675120.N1Q4W4"/>
    <dbReference type="eggNOG" id="ENOG502SYR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037645_1_0_1"/>
    <dbReference type="OMA" id="WFWTCAQ"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="393" mass="43061" checksum="44C7034D0059EB76" modified="2013-06-26" version="1">MERGGRYRSRGGRASGRGGAATATGKGVFANGTWHCNCTPRLPAEHFRVKKEGPNKGRWFYTCQQRQPTGARGCDFFLWDEEAKLREESTVLANSRNEPQQEMQDGKPLPQGRGLFSGTSSRQPVCREDSETPSPEPELRPANVSKKRNLRDMIMDEGEDGQPWSLSGNEQKELADTAAVSSTLETPQKAQKTGVYATPATSGKKSSRTLPWLKEQEVMTPATAKKQTVNDYFISPSTAKVGHKAVSFEVISSPSEEATPLTPLPQAQEVPTPAAPLTPSPPSRHKDALVNPADSASSLTTEVLAELASIKLRPEKLASIRSILSKHDLKTQGVTKGRDISRLAVKARDAKIVQLESTIASLEAQRELDRSVIDQLKWKREHVGEEGEEESQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2WIS9</accession>
    <name>M2WIS9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_160582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WIS9"/>
    <dbReference type="STRING" id="675120.M2WIS9"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_0_1_1"/>
    <dbReference type="OMA" id="ICWDEDA"/>
    <dbReference type="OrthoDB" id="5410178at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF157">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="50"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME38868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="526" mass="57290" checksum="53F7C769E98C7DF4" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2XHI2</accession>
    <name>M2XHI2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_83554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XHI2"/>
    <dbReference type="HOGENOM" id="CLU_969854_0_0_1"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32462" checksum="4D7B4C4E191B87E6" modified="2013-05-01" version="1">MSPAVPGAQLWVELEVEAWRAQRNGEGGDHGIGGVRTSARRRWDTMAEDRRSRLEAALRRWRASQARVATLLPVYEHEPNPDDMSAVKEYYEANEALATAMQSGNSSLEDLVTLHEALDDSGHISRDWLQRQDTCSEDLIDQIDERSLVWFKIRRAAEAEEQEDEYDEEASEEYALASGKLRRGLCHCTGNDSDWMIEITITKQPTTSTTRPRCRLFHWTTAGLLMERGRVEKVPDGLYQDWKEIVHGDLKLSTVFLGDNTSEVFRGYPQAKLGDIGSTVIADHGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2XHR6</accession>
    <name>M2XHR6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inositolphosphotransferase Aur1/Ipt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_75630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XHR6"/>
    <dbReference type="STRING" id="675120.M2XHR6"/>
    <dbReference type="eggNOG" id="ENOG502RF04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035756_2_0_1"/>
    <dbReference type="OMA" id="CFFINRI"/>
    <dbReference type="OrthoDB" id="2566866at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF10">
        <property type="entry name" value="INOSITOLPHOSPHOTRANSFERASE AUR1_IPT1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="181"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME38997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="420" mass="47702" checksum="FF7CE2BD4E1ED69E" modified="2013-05-01" version="1">MAHHNGTMPDLGKPQSEARAWFEPVLVVSIMAASLYFNRDRTFSIIPSQDERYDASSEYLIKTQNGEYEESRSSSRSASPDRPKDSIDQQRGTSPSQRNEDVSPSSMNFPSRILQKFPFLIEMFYWALNYVAYAMTKKLGAALYSRYDGQNQVTELAQQNGIDILTFEHDTIFSIFFPMTEVAFQQFFIKHHLMILSFFNQIYSLVHIPGTVAFLSWYYYVAPSHDTFATVRRTMTLGNFSAFFIFSLYPCMPPRLLPESFGFKDTVRQDNAESVWVGGANVNQLAAMPSLHFTYAFVIGCTFLFQSGVLATCFGRRASVAASRTSRSWRSNMSVVYAVAGAVYPILVLSVIVATANHYYLDAVVATFSVTLCFFINRIWIVLLPAERLLCKVLRLRKPTPTTARNSIPERPRVVVEQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2XI64</accession>
    <name>M2XI64_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DOTSEDRAFT_179601</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XI64"/>
    <dbReference type="STRING" id="675120.M2XI64"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_16_3_1"/>
    <dbReference type="OMA" id="CYRSWVR"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990625">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="233"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="434"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="597"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EME39162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="689" mass="72221" checksum="2E2C2090E6CE3959" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKG3</accession>
    <name>M2XKG3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_45029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKG3"/>
    <dbReference type="HOGENOM" id="CLU_3074189_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="53" mass="5375" checksum="338AB87C83D051B8" modified="2013-05-01" version="1" fragment="single">TILLLGADSGLVGIWAYNHTLHSISSYIGPGVTGTGCTTAVPEAAESSLASWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y0J2</accession>
    <name>M2Y0J2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_39029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y0J2"/>
    <dbReference type="HOGENOM" id="CLU_2096815_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="116" mass="12529" checksum="5E153D4C106BBE86" modified="2013-05-01" version="1">MAQSCAESPTRDVIRETINDTLSDILGNATSTSELNSSAAQYRTIADVFMSLPVACGAHLTRRLQIGYDRDGILLHDELEATGCNSQPSPRLSHYIIPLVTLQRHGTPGCGFVPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJ79</accession>
    <name>M2YJ79_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_181067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJ79"/>
    <dbReference type="STRING" id="675120.M2YJ79"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_14_0_1"/>
    <dbReference type="OMA" id="RWNTRLV"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF8">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="15"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME38995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="607" mass="67250" checksum="5D8A061F1010D3D3" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKG6</accession>
    <name>M2YKG6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_91733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKG6"/>
    <dbReference type="STRING" id="675120.M2YKG6"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="OMA" id="SWANPIR"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF156">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME39350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="477" mass="53620" checksum="F8DE76A8E33B81BD" modified="2013-05-01" version="1">MSHKEDFLVITRAYYDPLRRVPGPRLCRFTPLYDWYKSWLGYECRWIEGLHQKYGPVVRIAPNEVVISEGEALAPIYTEKGGFFKSPAYVNFDSEGHPTIFSGLDSAHRALRAKAVMPLFSTGSLRNGTAALETCICGMIGRLEDQAEKSRGAANKTGGLAFVDVLNLSRRLAIDSLCAYLFGKDYGGIRENGTKLSASMFVDSIGDFGRFFFLPNWIFLLILNFNLKYFPDAAADKSAAKVDAFTGELVEKAEASDGTYQSRLLHAGISAQETDVQLKDVIFAGTDGLGTNFGALLWQLAKHPEVYKKLRAEVLDAEQQDPNYDVRELRYLDCVIKEGLRMALANPTRFPRQVPPTGFSYTSPSSKRTYYLPPGTLVGLQPRTLHFNPAVFHDPWTFKPERWLDPSHEMLRDWIPFGLGPRQCIARNLATYELLLTTRAVARSGVLEGAKCVQDRLDMVEWFNAKVRGDKIELVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2YME7</accession>
    <name>M2YME7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YME7"/>
    <dbReference type="STRING" id="675120.M2YME7"/>
    <dbReference type="eggNOG" id="KOG1672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072378_0_1_1"/>
    <dbReference type="OMA" id="CVIAFID"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24343" checksum="5045813999A788A2" modified="2013-05-01" version="1">MTSIDAHVAKVLDKQRLGQDSDDEDALIAELEDDEDNAFSALREQRLQQLHSEMARAKMMKEISHGTYMEIKDEKQLLDITTSEKLCIAHFMKPDFNRCGIMDDKLRMLAEKHFDTRFVSINVDNAPFLVVKLGIKVLPCVIAFKEGVSVDRIIGFEGIGYKPDSFTVAELEVRLLACGVLVRSKMNDDDDRRRERRREERVEDEYADDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBN9</accession>
    <name>N1PBN9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pex19-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBN9"/>
    <dbReference type="STRING" id="675120.N1PBN9"/>
    <dbReference type="eggNOG" id="KOG3133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043063_1_1_1"/>
    <dbReference type="OMA" id="YEPMKEM"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="34606" checksum="ADE76919F61C9BEE" modified="2013-06-26" version="1">MADKPPKNAAETAPDPDEDDLDDLDDVLDEFQATSITKPKAPSQSTPRAPSASGPGRPNDASPTTAASTTASEDDLAKQLQAGMSSLIGELDSNPSMQAEFEKMMQELIAAGAAGSDQEAGAHLQEAAKTVSEDTKPKSQSAAGSSSTDKKKPAFDSTIRATMDRISASNTAASTASTTAQNEEDLLAQMMKELTEGGMLGGEGGEGGDFNSMLMNMMAHLTNKEILYDPMKELHEKFPGWLEKNAEKTNKQDLERYKEQQVLVGEIVGRFEGKGYSDENEDDREYIVERMQKMQAAGSPPSDLVGDMSAAQEALGGLDQGCPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBR7</accession>
    <name>N1PBR7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_75921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBR7"/>
    <dbReference type="STRING" id="675120.N1PBR7"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_3_1"/>
    <dbReference type="OMA" id="MSSVIMI"/>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME38567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="116" mass="12485" checksum="E5703944AD6A4931" modified="2013-06-26" version="1">MSGLMRHAQGHFAYNAAKGATVHLTKLMSSEFQEAKIRVNSIAPGYFPSEMTAKESDSRNKSEFPEGKIESTGHVPIMRAGRDEEIGMAVLFLAKNCYVNGQILAVDGGVLNVVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBX2</accession>
    <name>N1PBX2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin reductase</fullName>
            <ecNumber evidence="7">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_92325</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="7"/>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBX2"/>
    <dbReference type="STRING" id="675120.N1PBX2"/>
    <dbReference type="eggNOG" id="KOG0404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_1"/>
    <dbReference type="OMA" id="GPCHVLK"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="4"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME38223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="358" mass="38615" checksum="978B0BBE1E917E73" modified="2013-06-26" version="1">MHSKVVIIGSGPAGHTAAIYAARADLKPVMYEGFLALGIAAGGQLTTTDEVENFPGFKMIKGTTLMDQMREQSEECGTEIVTQTVGKIDLSARPFKFWLNPMGDEETLEEETHTADSVIIATGAKARRLELPGEDKYWGNGVSACAVCDGSLPIFREKPLVVIGGGDSAVEEALYLTKKASKVTVLVRRDQLRASKTNARRLTTHPKVDVRWNSQGVEIKGDEGPKGLMKSLVIKNNKTGEQEEIPANGLFYAVGHEPATQLFKGQLKMDEDGYLITTPGTTETNVPGVFAAGDVQDKKYRQAVTSAGSGCMAALEAEKWLAENEEDVPNGIEGDSEVKKGKPEANGDVPEYRSNPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC34</accession>
    <name>N1PC34_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">DOTSEDRAFT_74737</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="26 27" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC34"/>
    <dbReference type="STRING" id="675120.N1PC34"/>
    <dbReference type="eggNOG" id="KOG0620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016428_4_0_1"/>
    <dbReference type="OMA" id="PHYYARA"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="25">
        <location>
            <begin position="388"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EME39968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="760" mass="87122" checksum="7B09F55C395D76E2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCU5</accession>
    <name>N1PCU5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_137925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCU5"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_1_0_1"/>
    <dbReference type="OMA" id="NALPCDT"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26493" checksum="838EA32A10302023" modified="2013-06-26" version="1">MAPTSRIFLTRHAQAQHNVDLDYMGNPDSPLTALGKKQAASMAHQIPKLQQEAELIVSSPLKRTLQTTRLGWGPAVERLGGIKKVVTLPQAQEVNDYPCDTGSSKEVLEADPEFAQFDFSSLTPDWTSKRGFWADDAETVRKRAQWVRQWLRERPEANIVLVAHGDILRRITGNEKGPSTYMWKNAEVREFRFRPDTVDKEEAYIYQEEEIAAAGGYAPSSTEADIIQAGHEQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCW1</accession>
    <name>N1PCW1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_82809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCW1"/>
    <dbReference type="STRING" id="675120.N1PCW1"/>
    <dbReference type="eggNOG" id="ENOG502S70K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072876_0_0_1"/>
    <dbReference type="OMA" id="GVAHSGM"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108709" description="MICOS complex subunit" evidence="3">
        <location>
            <begin position="32"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="257" mass="28089" checksum="92AF9D9044C9F47D" modified="2013-06-26" version="1">MAFAPLLRQHILPLAGLTAGVVLVPTRTVYAEEPPSDPIKAIRTRKPIYDSPTEELARQVGATTPPPASGITDKPQERENASTPHRPTPTDKLAAQVKASRLVLHSYAVKAEDAVNNGMTSFMDAEHSFTSTIASLAPPKASNEKLLPGGIYVLVAAMAGSIISRNRNILFRFATPILTGVVTAHYVVPRTTENVGNLIWKYEEKFPVVRDNHLRVSQGVRHFVETGKAHSQMGLAMAEEKVQEARESIQDWVKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE95</accession>
    <name>N1PE95_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_47192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE95"/>
    <dbReference type="HOGENOM" id="CLU_2757762_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="70" mass="7656" checksum="09E93F58F3531EAA" modified="2013-06-26" version="1">MKAHSTGNARWQSDVATIVRTYDGSDSKEIGGNSTTVRRSDFERPVLHSPHPSNQVLIHSSLIGSKPLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEC9</accession>
    <name>N1PEC9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_74287</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEC9"/>
    <dbReference type="STRING" id="675120.N1PEC9"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_4_0_1"/>
    <dbReference type="OMA" id="WNPFRHV"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="212"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="433"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME40687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="587" mass="63323" checksum="2759CCB9FDA42DE0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEG6</accession>
    <name>N1PEG6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_37326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEG6"/>
    <dbReference type="HOGENOM" id="CLU_1547552_0_0_1"/>
    <dbReference type="OrthoDB" id="10472199at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="173" mass="19036" checksum="1719F578873153E1" modified="2013-06-26" version="1">MHGLHPQPNPISILPASTTPPPAFPPRYNLQLTKSSAASVSGAASNKNALASKRVEDFVHPPFIAKSQTNNAYAQPNAIYVVQHLIEEYTGPGPNFDLEGAKKYPIAIRSFMDKGLAESFAKTFSFERARMLGLGQSEWGQESRGKELQSCSWDTVGWGWKICTRDGIRKETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF23</accession>
    <name>N1PF23_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_73587</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF23"/>
    <dbReference type="STRING" id="675120.N1PF23"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001583_0_0_1"/>
    <dbReference type="OMA" id="PQWDMIT"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000014">
        <property type="entry name" value="Cation/H+ exchanger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1023"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1095"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1130"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1158"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="12">
        <location>
            <begin position="320"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="604"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="1022"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="870"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="941"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="901"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="954"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="968"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME41213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1215" mass="134009" checksum="03C0317CA4C56C8A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF52</accession>
    <name>N1PF52_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF52"/>
    <dbReference type="HOGENOM" id="CLU_1992587_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="125" mass="13606" checksum="13E99A719AB3617F" modified="2013-06-26" version="1">MMPRKIEPSASETVHLVIATASPQIDLRQRRLPMLLHGTQGSTLLVRYAVLPKQGRLSSPSYLRCGVPTNQGYNLPASFTPGMLTLRLCTRFIRTCALPRSALSPSASSKKSSSVAFAISCHVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF60</accession>
    <name>N1PF60_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate-binding module family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_74311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF60"/>
    <dbReference type="STRING" id="675120.N1PF60"/>
    <dbReference type="eggNOG" id="ENOG502QTS6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_619668_0_0_1"/>
    <dbReference type="OMA" id="HNGANSC"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012949198" evidence="4">
        <location>
            <begin position="16"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="153"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME40724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="442" mass="45094" checksum="71A0743BB12B2DAC" modified="2013-06-26" version="1">MHAIAILSLAVLATAVPHRHSHQHLHAKKNLEVALAGRDNIDWNLGTCGGSTGFTCGTGFCCSKWGYCGTDSDYCGAGCQFGACNGEKGDKGEAAPANNTATTISLGKVFPVAYTLSPAMSSIAWPAEAPATTLTAKVSAVADKGHSSQTYGAAPPAYSSPVESPASSVATPAYTAPSSSSEAAPVAISSTTPPVYSATTTKSHSAPAPTSPSVPAYSSPSSSSSGGDAGLGNVYSMYTGNGEQSVGWPAESLWMSFDDAWKGNLDIMAKSCTQWGVDNNSDQENADLKSAIQSVAQSSGVDERFILAIVMQESNGCVRAPTTSYSVSNPGLMQSFEGTATCNPGSSTAPQGQTPCPSSSITNMIEQGTNGSKAGDMSLVYALQQAGCDDISKYYKAARIYNSGSIASGGDLGSGVATHCYASDVANRLTGWTTATCGCNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF77</accession>
    <name>N1PF77_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gem-associated protein 5 TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_74323</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PF77"/>
    <dbReference type="eggNOG" id="ENOG502QVI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000799_1_1_1"/>
    <dbReference type="OMA" id="PFPGELQ"/>
    <dbReference type="OrthoDB" id="7326421at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034605">
        <property type="entry name" value="PGC-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056421">
        <property type="entry name" value="TPR_GEMI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528:SF11">
        <property type="entry name" value="FI18188P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528">
        <property type="entry name" value="PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 PGC-1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23774">
        <property type="entry name" value="TPR_GEMI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Gem-associated protein 5 TPR" evidence="8">
        <location>
            <begin position="562"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="779"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="921"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="970"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1596"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1708"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="852"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="883"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="938"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="972"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1112"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1144"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1164"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1187"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1206"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1253"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1281"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1349"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1402"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1712"/>
            <end position="1725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME40744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1760" mass="190479" checksum="764456F712B27A57" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF93</accession>
    <name>N1PF93_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_27375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF93"/>
    <dbReference type="HOGENOM" id="CLU_1875391_0_0_1"/>
    <dbReference type="OMA" id="IFRAMYW"/>
    <dbReference type="OrthoDB" id="10422640at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="136" mass="15432" checksum="DBBDC0FFFACCD86D" modified="2013-06-26" version="1">MTIPSNYIATQSDAQRADLRKMFADRGRGYEQQLYLRDRHSYHIFRAMYWQLQIYDDKYGFPGKYDTPAKACPPPPTSSLKPYPGFGRPLSAISEATVETEGWSDRCTDDTTLVDQPIMSEIVLRFADVPESGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFC8</accession>
    <name>N1PFC8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_27409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFC8"/>
    <dbReference type="eggNOG" id="ENOG502RHG2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1396289_0_0_1"/>
    <dbReference type="OMA" id="RYYTHTI"/>
    <dbReference type="OrthoDB" id="3634448at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="195" mass="22919" checksum="44CDA38BAAE917DD" modified="2013-06-26" version="1">MSARNMNEIQGRIQGMAQELRDMIFDFVLTVDMPDDNNITIDEDYEPPVQLQINSATRKSIGQRYYTHTIFTFLNFYDGEALCMSWIDSLSPENQQQLNQVRLAYPRPHRISDYIGTPFQQLRHLYMSMYRVSYYLSRDVKFKVARMGELLHVNVERTRRTGQREVLWLPVGIPGVGREDMWKYVVAVVLEDAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFF4</accession>
    <name>N1PFF4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_74786</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFF4"/>
    <dbReference type="STRING" id="675120.N1PFF4"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049413_3_4_1"/>
    <dbReference type="OMA" id="WIIPNAM"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="11">
        <location>
            <begin position="31"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME40031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="261" mass="28646" checksum="91224436562D696A" modified="2013-06-26" version="1">MSATRRRMTLPSEPKREDPIYKPAEKPCSQPDHGAAFILVHGLGDTAEGLENIADQFQQNHKLPYVHWIIPNAMENRDAMSTAWYAPNSFSVYPADRPDLAQTEDIDGLQSSLTYLESLIDACVRKGIPPQRIVLGGFSQGCALSLLLDLTSKTYAGKLGAIVGLMGYLPLAEGRQLEDMRAHAGLPIDHGDVPIFLARGAADKMIPGRVWKQTLEKLERLGVGKDHLNVKEYEGLGHGLSGRVLGDVCSFVERYVPALED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFI8</accession>
    <name>N1PFI8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_46385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFI8"/>
    <dbReference type="STRING" id="675120.N1PFI8"/>
    <dbReference type="eggNOG" id="ENOG502SNAE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049749_2_1_1"/>
    <dbReference type="OMA" id="FDVITMN"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="81"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME41373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="316" mass="35836" checksum="7B386E179119D343" modified="2013-06-26" version="1">MSTVNSRHNPQLVNGDQVDTYDDYNNDNMAAWKAMASHWEEYHSENDMDGNDMFTQCLLPVVAELSDMPAKDAHPHWAPTVLDLGAGSGIIARMMARQGAHVTGLDYSHEMMEMGRRRAAKETDLKGTISYDLIDLTDYEGMAKFMETHERYDIVTISTTLKSLPTLDPIARALRLMIKPEGRIVVVDLHPAFSKPAGHRGMEVYEDPKTGKQQLSTYIKVPRYLNIPPTKSEAVRGQPEPLWVFHRPFEKLMEPFFRNGLVLDAMREPAFEGEPMPSQAQNYHNFQQTPMLLGFRLRLADRASLPKANSKLNHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFK7</accession>
    <name>N1PFK7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoporin Nup159/Nup146 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_179452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PFK7"/>
    <dbReference type="eggNOG" id="KOG3630">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003852_0_0_1"/>
    <dbReference type="OMA" id="RGQCASI"/>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="6">
        <location>
            <begin position="44"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="542"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="767"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1438"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1306"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="549"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="566"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="734"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="796"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="970"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1070"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1439"/>
            <end position="1453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME40370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1510" mass="159994" checksum="0BA0D3064FC89148" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFY4</accession>
    <name>N1PFY4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_116548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFY4"/>
    <dbReference type="STRING" id="675120.N1PFY4"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="OMA" id="MWIDSAC"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="249" mass="29028" checksum="BD1A18ABEDD84FEA" modified="2013-06-26" version="1" fragment="single">MRLLRTDTQDLKLVSFNDETQVPHYAILSHTWMADEEEITFGDLKVQDNLTIKAGWIKIESARRQAREDGIDYVWIDTCCIDKNSSAELAEAINSMYRWYRNALVCYVFLMDLPQEDAQMDTVSALSLCRWFTRGWTLQEMVASKHVRFYGATWHFAGTLFDLAEPISRVTGIDVDALQQLRPISSYSLAQRMCWASRRNTTRIEDRAYSLLEIFDVSMAVIYGEGERAFQRLQEELLRLYSDQTLFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGF1</accession>
    <name>N1PGF1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_178637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PGF1"/>
    <dbReference type="eggNOG" id="ENOG502R0AV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278102_0_0_1"/>
    <dbReference type="OMA" id="QETHAND"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019528">
        <property type="entry name" value="PACT_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10495">
        <property type="entry name" value="PACT_coil_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="7">
        <location>
            <begin position="181"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Pericentrin/AKAP-450 centrosomal targeting" evidence="8">
        <location>
            <begin position="1203"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="416"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="899"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="912"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="979"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME40401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1307" mass="151296" checksum="516FCC2E5A0E7EB3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGI9</accession>
    <name>N1PGI9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_46266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGI9"/>
    <dbReference type="STRING" id="675120.N1PGI9"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_14_2_1"/>
    <dbReference type="OMA" id="QWPAISV"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="488" mass="51831" checksum="113B463E85592BEC" modified="2013-06-26" version="1">MSPTTSRYGSIAELQKAYQDGNVSVKEVTQQYLATIESLNGDLNALTAVNKNALDEAERLDGLPREQRGPLYGVPMVIKDQIETAGIPTAYGSAACKDYIPPKDATVVTKLKAAGVVVLGKSTMCDWAAGWVSASSLSGTTKHPIDHARDPGGSSSGNGTAVASDMALAAIGGDTGGSIRLPASFCGLVGVRVTPGRISRDGMSSLIQTLDTPGPMVKTVEDAARLLDVLVGFDENDDFTSINAMTGRSTSATQFVDAIKQPLLEGKRLGILRQAFGDHKGVNSVLDKALLDLKDAGVELIDVEIPNLEDYLTNTSGYILRSKSDVNHFLASREGLAHLKLEDLHSAGTYHKSLDLINMVVKGPTDPSMSPHYARVLAKVGEFQRTVGSIFAKYNLDAIIYPTSKQLAPKTANVLAMDSHLNTDSPNTIIGSQLLFTALSVPIGKAKDDLYPDDPELPVGLEVLGVPLSEERILNIAAAIEALQHKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGL1</accession>
    <name>N1PGL1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_27299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGL1"/>
    <dbReference type="eggNOG" id="ENOG502S8NB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138726_0_0_1"/>
    <dbReference type="OMA" id="SFYLGPE"/>
    <dbReference type="OrthoDB" id="3913322at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109739" evidence="1">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="148" mass="15472" checksum="0C3C6B2D1AC81637" modified="2013-06-26" version="1">MRTALIATAASLASVATARIVGFSVPSTVKPDSIVKLQITAEDYIQTTQDVTLSFGISTSKAAVLGSLGEYLDTKFLGPDFSNEVGNITHYVRIPATAAKGDYVIQGAHFELTGASISPATSVYYATTTVGDNTSADYVDSTLVPQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHF5</accession>
    <name>N1PHF5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHF5"/>
    <dbReference type="HOGENOM" id="CLU_2236522_0_0_1"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109103" evidence="1">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="105" mass="12673" checksum="96C82D2EA9BBBFDE" modified="2013-06-26" version="1">MFLFLCVTSLFWTLVSVLTLWFSEPYSEQVRQDLHNPTLLPATARKCYIFPEHDLMFAWDSPTDDDELCLRQEFHVRRNSIDQKQQWTSNQERYWLGIENAWDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHQ8</accession>
    <name>N1PHQ8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_27020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHQ8"/>
    <dbReference type="HOGENOM" id="CLU_2333596_0_0_1"/>
    <dbReference type="OrthoDB" id="10552029at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="98" mass="11233" checksum="41B0C0D4C00C0F37" modified="2013-06-26" version="1">MHSHPKRDEDGYSTLDLSNFPEQGRPGYIDEEEAALPEISYHDAYGKLISWEDVNRLAAEEVDREANDTLHVMYPDQYPCTTRASVPLSSLRDPHQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHZ8</accession>
    <name>N1PHZ8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein L30 ferredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_73950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHZ8"/>
    <dbReference type="STRING" id="675120.N1PHZ8"/>
    <dbReference type="eggNOG" id="KOG3184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055156_5_1_1"/>
    <dbReference type="OMA" id="NCFPENT"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13823" checksum="288F51006BF80D0E" modified="2013-06-26" version="1">MLKIVEPFVAYGYPNLKSVRELVYKRGYAKTSQKQRIPLTDNGIIEEHLGQHGIVCMEDLIHEIYTVGPNFKQASNFLWPFKLSNPTGGFHKRKFLHFIEGGDLGNREEYINQLIRQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIA7</accession>
    <name>N1PIA7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear assembly factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_174961</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIA7"/>
    <dbReference type="STRING" id="675120.N1PIA7"/>
    <dbReference type="eggNOG" id="KOG2236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_710896_0_0_1"/>
    <dbReference type="OMA" id="HDDNIAM"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex non-core subunit NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="261"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="323"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME42117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="389" mass="41671" checksum="4E6E64251912BE7A" modified="2013-06-26" version="1" fragment="single">MAAAAVQKGNQDAEWNFDPSDAESSSDLDSSDSDDSSDDSDSGSEGGYEMLDPATAAKILMSGDGDDDGGTGKDKSGADHQPRTANETKEEVVPKPDVQVTEDMNITYLGTVDRTVENMVLIKGATSGDYQVLESGSVLCNEKREVVGAVADTFGKVQEPLYSVAFTNAQGVQEAGLEFGTRIYYVDTHSTFVFTQPLRTAKGTDASNIHDEEIGEDELEFSDDEEEAAFKSQRKRAKKEGRTALTRSEFQAGARSFVASGHDGGHTYTGNSSDVPAQSYGGALSYDDEPTGEDFYQPLKRPENLAQLMSNGAPPPRQQPSTDRGRGRGRGDGADRGGRGRGRGGDRGGRGDRARGRGDRGRGRGGLDRDQRGGRGGQRGQHQQNHQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PII3</accession>
    <name>N1PII3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_73687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PII3"/>
    <dbReference type="STRING" id="675120.N1PII3"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_7_1_1"/>
    <dbReference type="OMA" id="NHFESCA"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME41350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="544" mass="60172" checksum="8B0E7AD6655D435E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PII5</accession>
    <name>N1PII5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_73114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PII5"/>
    <dbReference type="STRING" id="675120.N1PII5"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116866_0_0_1"/>
    <dbReference type="OMA" id="RECWCAQ"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109802" description="WSC domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="41"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME42182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="177" mass="18162" checksum="1714F0F4202CE371" modified="2013-06-26" version="1">MLSALFAALLASALAVSAQDTSIVYPTTAAPTATTLPSLNGYTFAGCWNETDGFTQDGGARALQGNNTASNTLTPSSCISFCASLKPAKQYAGLEYGRECYCSNYLSAFSTELNASSCNFACNGNGSEICGGRDAISLYNKTGDVKSEGRRGIGHGGEGALVYGVLAVGMLGFAMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIP0</accession>
    <name>N1PIP0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 93 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_81183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIP0"/>
    <dbReference type="HOGENOM" id="CLU_602526_0_0_1"/>
    <dbReference type="OrthoDB" id="10340135at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108825" description="Glycoside hydrolase family 93 protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="53288" checksum="8A85AB07A2C28CA0" modified="2013-06-26" version="1">MYTPMRCLWATAVSLPLVSAVNGGSSPNAPTTYTSGSIVSIPGGSSSGLKSGDYQYTGFGAAESNINIAQDGSLIYSPAFTTSGVGYATSKDSGNTWAQVLPGGSAQPRTQPVFRKVASSDRYFFWSSSIPGLDFNYSDDDGTTWTNLNASHFDQSIQDWAKLVNGKPVRSKLTNGAKEILYLSAPSLISTPIPVQPLGPIDQMIIKSTDGGSNWTVTGSQPTLQPALSGGACAGLTQSLLGQELIIWGDGFVTPNGTIMYGLRRCQKLSVAISDDEGDTWRFSDLPQSSLVPFIVGDLTYTFDGNVLVPEPISMDISGNIYAIYVDSQYVLKMSVSKDFANTWSAPIVIAAPGNSTTNSLMTYLPTLRQHPTQAGRAALSYYGSSNGGATYNAYMAETVNLGSSAPTWTSIIANPPSQPMQNNSDRAWDQGYGNPLGDLIEFTDILYMPNSTNFVAAFARKMCTAPITPFYDGSSCVDGWNYTAHGNSAFQGFVAFGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIS8</accession>
    <name>N1PIS8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_72959</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIS8"/>
    <dbReference type="STRING" id="675120.N1PIS8"/>
    <dbReference type="eggNOG" id="ENOG502QUQ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026011_0_0_1"/>
    <dbReference type="OMA" id="IDPHPLA"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000010">
        <property type="entry name" value="GRF zinc finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="265"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="7">
        <location>
            <begin position="387"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME42034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="465" mass="52588" checksum="155DD67E988E168E" modified="2013-06-26" version="1">MRPAYTVGEATMETFLQSKPKRLKPAEEAHELARMADSGENAEDTDFKLAVLASLHPELSQEILLESLLDSGGSAVKASEALSGVFNNATERKRKVPATIGYQSSIHSFAAKSTEAKEPGRETRRLAPKKGKTLHLYSPEDIEKHTPCSIIHNFLPAELSDALLKELLGEVPTFQRGTFQMFERTVQSPHTWKFYVDTLEELKRQKTEYTYDGSLYESQLSQTTPVMLEVSGLVKESVNQQVERRMRDFQPNGERLKYQSPDTWEPNASFVNCYDGGKENVGYHSDQLTYLGPRAIIGSLSLGVGREFRVRRIVPPDASQADEQGQIAIHLPHNSLLVMHAEMQEEWKHSIAPAQAIDPHPLAKNKRLNITYRCYKDYLHPKYTPKCRCGVSCVLRCSQKQKVTRGRYMWQCYANYTPGQKGCTYFVWAEFDEEGKPPWAEGYKGNANVPILGEEFLVENSTAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ01</accession>
    <name>N1PJ01_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ01"/>
    <dbReference type="STRING" id="675120.N1PJ01"/>
    <dbReference type="eggNOG" id="ENOG502S2W1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_6_2_1"/>
    <dbReference type="OMA" id="WYDNFAG"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="232" mass="25088" checksum="368614F779CEE347" modified="2013-06-26" version="1">MLWGTGDSSSFYTTVKGLKDGGMNISSVLFFNEPDGCGQVYGGSCIDVETAAATWKSQIEPLKDLGIKLGGPAVTSANSGFTWLQNFFTQCAGGCSVDFLPVHYYGDFQGLASHIGQVNATYQNISSMWVTEFGYPNQSLEISQNFYNQSVAFLDRVPYIQRYSYFGSFRSDVSNVGPNAAMLTQKGQLTDIGAWYLGDAATGNIPKGDGAHLARFAGWPLVVFAALFYCIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJQ1</accession>
    <name>N1PJQ1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_53046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.176" evidence="1"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJQ1"/>
    <dbReference type="STRING" id="675120.N1PJQ1"/>
    <dbReference type="eggNOG" id="KOG1406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_0_1_1"/>
    <dbReference type="OMA" id="ACGVHIL"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="7">
        <location>
            <begin position="15"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="8">
        <location>
            <begin position="264"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME43727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="458" mass="49643" checksum="3D0F1B9049DBFBCB" modified="2013-06-26" version="1">MSRPLSNAYVLGVGMTEFIKPRRVREYPELGFEAGVKAMLDAQITYDEVQFGVGCFCYGGTCSAQRVFYQFGMTGIPILNTNNACATGSTGLHIARTMVRNGAADVILVVGFEQMAPGAIKDPFEGLPSPMEFSRKMMEETRGRHDSPHTAQYFANAGRAYMEKYGARAEDFAEIARISHEHSTRNPYAQFQKAYTLEEILSSTMIHAPLTKLQCSPTSDGAGAAVIVSEAYLAKKPWLKSQAILMAGQSMMTDTPTTYSRDAIDLVGYDMTARAVDVALREAGTSSKEVGVCELHDCFSTNEMILLDGLGFSDKGKAHLMVRNGDITHGGKGPLINPSGGLISKGHPLGATGLAQCCELTWQLRGWANNRLAPPTKIALQHNLGLGGCVVINVYRRADGKGSAQMTDKEIASSTNWTYNPATSARVVSPEDVAKVVSRKAKVEYVQGDTLEKIQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJT1</accession>
    <name>N1PJT1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_46704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJT1"/>
    <dbReference type="STRING" id="675120.N1PJT1"/>
    <dbReference type="eggNOG" id="KOG4159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013989_4_0_1"/>
    <dbReference type="OMA" id="PWWFASV"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16514">
        <property type="entry name" value="RING-HC_LONFs_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="6">
        <location>
            <begin position="278"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME41805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="58555" checksum="FE539C2085A987F2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJX1</accession>
    <name>N1PJX1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_36970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJX1"/>
    <dbReference type="HOGENOM" id="CLU_1378092_0_0_1"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="198" mass="22183" checksum="08D3F05C1C092817" modified="2013-06-26" version="1">MQAVNTDATNRQTLFVAPNGGDNKIGIVTLACCVRWTWHPGASIVAIKGSFTSSERALDAIYPFTARSNKDFNATVAVHFRFNGIDLDVLPQFRSTVKQKTITELSEELPVRRPVGNRYLTTPVGIVNNRTMLQNVRINTGSFYRSASNAMYPAKFQCTFVYEPLPHCYPGRSIARDCNMLGLNNTRDDYVIVQLQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK00</accession>
    <name>N1PK00_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_101764</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK00"/>
    <dbReference type="eggNOG" id="ENOG502RXC5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046558_1_0_1"/>
    <dbReference type="OMA" id="QTRCVQI"/>
    <dbReference type="OrthoDB" id="5295771at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME42449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="271" mass="30307" checksum="E4725F617FF32963" modified="2013-06-26" version="1" fragment="single">DARFEVVGSPFSLLSASISPSQNLYTRKGTLVGFNGKAENAVSSLSLLEPFRRAALGIPFLYQRITSTTPYTALIATKSSITSLVVVHLDGRLDWMIARRNALLAWTGHTLSLKPRWNMKMSMAHWGSTTVTGRGLLALSGKGLIHQISLKTGEEYVVSPRNVIAYSMMQHAPQPYRFKSNNLRLQIPNPFTWLPDTRFWRTIRDSTLYKLLRDASFAIRTLARRTIWGDRLFLHFKGPATILVQSRATRLSESFTNQDVNEVADAPAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK63</accession>
    <name>N1PK63_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-gulonate 3-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">L-gulonate 3-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_129838</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.45" evidence="8"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK63"/>
    <dbReference type="STRING" id="675120.N1PK63"/>
    <dbReference type="eggNOG" id="KOG2305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_0_1_1"/>
    <dbReference type="OMA" id="MRYALMG"/>
    <dbReference type="OrthoDB" id="2021159at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050104">
        <property type="term" value="F:L-gulonate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF1">
        <property type="entry name" value="LAMBDA-CRYSTALLIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="12">
        <location>
            <begin position="7"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="189"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME43902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="320" mass="35294" checksum="CE9E383F9234AB11" modified="2013-06-26" version="1">MAGVIRTVGVVGTGVIGASWTGLFLARGLRVIVSDPSPGAKEELEKNVKSLWPRLEKLGLSRDASLKNYEFVGGSMQKDHYRELDFVQENTPEEQSLKEKIVGEIDANTKESAIIASSSSGIPSSQFIGKCEKRPERVLIAHPFAPPHLMPLVEVVPHPQTDDEVIKRAMDFFKSLGKHPMHIKHEIPGFIANRLQAAVSAEAYSLVHRGILSAEDLDAAVTTSIGPRYALTGPFMSNVIGGGSHRDGFKDFATKLGPAVQDWLKDMREHAFESNEENIIKLNESVHKQLDKQPPGETEAERDEVLIELQDAKKTKKYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKA0</accession>
    <name>N1PKA0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_112301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKA0"/>
    <dbReference type="eggNOG" id="ENOG502SU96">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116849_1_1_1"/>
    <dbReference type="OMA" id="TIVPWAF"/>
    <dbReference type="OrthoDB" id="5309803at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="80" mass="9405" checksum="3CA42A1854E4BB71" modified="2013-06-26" version="1" fragment="single">MGWFSILPEQFASIEKWLVRLFLLCAFLIFGPWLFMIVYDILLYVWRAATYELPVVGGRAHGRQRPRAPSITERPSGHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL03</accession>
    <name>N1PL03_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_71851</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL03"/>
    <dbReference type="STRING" id="675120.N1PL03"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036835_0_0_1"/>
    <dbReference type="OMA" id="TNPWVSA"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000793">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="239"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME44167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="350" mass="37571" checksum="F8F9F08E24F59FAD" modified="2013-06-26" version="1">MAMAVDSRQQHHQFSPMGYDAMRYPHAPQFTNPWVSGPAPQSQLYATAMPQSSAASDARYVQASNVSTAYAGGLPATSVSSDMSAPRPYAPSYSSAASAASTYAPTSAPQYVPAYGYQADRRSSHPSVASTAFQGDPVAVQRYRQSSLVDVNDRISHASEAERQHFSEALDASRGMVAMSQSDITPRNIYGSSSSGRASTDSYGFPSHSSHSSISSASTYPAYYNSSVSEASVGDYSSASESVDIPSRTLPRPGALISGAMPPAPQSMMGQFSSKVSSSSQKKHKCKICDKRFTRPSSLQTHMYSHTGEKPFACEIEGCGRHFSVVSNLRRHRKVHKGEGHDHPSPDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL67</accession>
    <name>N1PL67_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_71922</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PL67"/>
    <dbReference type="eggNOG" id="KOG4231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_236490_0_0_1"/>
    <dbReference type="OMA" id="DRHWPCE"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07199">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="234"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="1114"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="16">
        <location>
            <begin position="1181"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="1782"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="364"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1671"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="12">
        <location>
            <begin position="1185"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="12">
        <location>
            <begin position="1219"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="12">
        <location>
            <begin position="1380"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="1221"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME44237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1868" mass="208917" checksum="A7F89CF16FEA1B85" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLE5</accession>
    <name>N1PLE5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_73261</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the SKN7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLE5"/>
    <dbReference type="STRING" id="675120.N1PLE5"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008776_2_0_1"/>
    <dbReference type="OMA" id="TNVDPGW"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000212">
        <property type="entry name" value="Stress response regulator/HFS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000380">
        <property type="entry name" value="Transcription factor SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014402">
        <property type="entry name" value="Sig_transdc_resp-reg_Skn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002595">
        <property type="entry name" value="RR_SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="16">
        <location>
            <begin position="376"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="206"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="276"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="497"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="583"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR002595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME42375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="641" mass="70259" checksum="3DD23F8A1D2C8A2D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLV0</accession>
    <name>N1PLV0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLV0"/>
    <dbReference type="HOGENOM" id="CLU_2114659_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="115" mass="13335" checksum="33BF8836B5BD4FCE" modified="2013-06-26" version="1" fragment="single">MPYMLEPVDEIGPQRATNRAKQTYSLDRYLTSGPQDEPYNAMDVPRYLALEESGKKRARIQLWFSKDSRQDFVDTTLEHRSESGMEGARAFKPCHQYYRWSNSGGHSKTARCPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM25</accession>
    <name>N1PM25_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_73264</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM25"/>
    <dbReference type="STRING" id="675120.N1PM25"/>
    <dbReference type="eggNOG" id="ENOG502QT79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008244_1_0_1"/>
    <dbReference type="OMA" id="QYVPPVW"/>
    <dbReference type="OrthoDB" id="5284003at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME42376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="776" mass="86160" checksum="FC8B4A9854C9F8A7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM93</accession>
    <name>N1PM93_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="2" type="ORF">DOTSEDRAFT_172697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM93"/>
    <dbReference type="STRING" id="675120.N1PM93"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055721_2_1_1"/>
    <dbReference type="OMA" id="RRADMRF"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="236" mass="26554" checksum="5A1A1644B59D09F0" modified="2013-06-26" version="1">MSTLAREFEADANGCGVSEDFVHSREHKAAGEKSIDFDGLLSPPLILHEDVTNGNGGQAWIAGMILTKYLLRMRRKELQHASIVELGAGGGLTGLAIAIGSEPKYPVHTTDMQSMLELMERNITLNSLQDQVIASVYNWGESRPCKIPPSPDIVIAAECVYFEPAFPLLQQTLRDLIGTNTVCYFCFKRRRRADMHFLKAVRKMFLVEDITDDPDHERYARENIFLCTIKRKAPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMR0</accession>
    <name>N1PMR0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_26302</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMR0"/>
    <dbReference type="STRING" id="675120.N1PMR0"/>
    <dbReference type="eggNOG" id="KOG0923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_7_0_1"/>
    <dbReference type="OMA" id="PLDPMMS"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000726">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="449"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="638"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="69"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="197"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME42751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1080" mass="123102" checksum="B9F75D5274774D0D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMR3</accession>
    <name>N1PMR3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_26337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMR3"/>
    <dbReference type="STRING" id="675120.N1PMR3"/>
    <dbReference type="HOGENOM" id="CLU_1057781_0_0_1"/>
    <dbReference type="OMA" id="TMVPVST"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="2"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME42790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="263" mass="24820" checksum="4BE3BB134CD56E24" modified="2013-06-26" version="1">MIAATIVAMIAATIVAMIVATIVAIIVAMIVATIVAIIVATIVAIIAATIAATIAATIVATIAAMGAIATTIAAMIVATIAATVVATIATTIVATIVAIGAIATTIVAMIAAIIAATIVATIVATIAATIVATIAAMGAIATTIVAIIAATIAATIVATIVAIGAIVTTIAAMIAATIAATIAAMIAATIAAMIAATIAAMIATTIAATIAAIGPIATTIVATIVAIGTIATTTVATIVAIGAIATTIAATIAAIGAIQRLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMU2</accession>
    <name>N1PMU2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyl-CoA thioesterase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_171582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMU2"/>
    <dbReference type="STRING" id="675120.N1PMU2"/>
    <dbReference type="eggNOG" id="KOG3016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032690_0_0_1"/>
    <dbReference type="OMA" id="DSSIWFH"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="156"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35071" checksum="9CF12CF96708C809" modified="2013-06-26" version="1">MEQLLDLRRLTSDTFITVYDPWLPPGAQAIYGGTMVAQCIIAAQATFRIDCTIASLRSTFVQGGKPNTPIHYKVHEYESDASIPLRGVRASQDGQCIFTAVVRFRLSPRQGCSRPSSNFQATGSQTIGPIKGGGGAVESPYICSDLQLISKTTNSVQGTTIAQWLKACRPIMVDNPAIHLAALAYMSDNYLLPTATRVHGIRWSRDPEVVPAALAGKQVQALEHGVKLMVSLDHTIIFDQASEAVRADAWIRSEMHSPWAGQERALVSQRMYSTTGNLLATVYQEVSSLTPRHVCHRLTALPGCAADESDRAFDALNVEWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMW1</accession>
    <name>N1PMW1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_72275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMW1"/>
    <dbReference type="eggNOG" id="KOG2765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025401_0_0_1"/>
    <dbReference type="OMA" id="CSTFFAA"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="430" mass="47009" checksum="16D8630E4A3F3D7A" modified="2013-06-26" version="1">MSRLMPDTARRKPKEDDHDEPLLEDGRNSHESDVELAELDEWGGYNLEGERTPASHYRDRDHVPPKRVAAWKIALALTICVAGLVINTEATAYFEDEIGWKKPFASMYLMHSSLAFPWVFHLGWERWKNRTTPYMRWVRDYNNELRGLIASVPAFATSGPSILKYMKLPGQIGGPLDYMCTTMAIVTIALTCSGGSWFVALALTTPGDLTAIYNCATFFAAAFSIPLLGERIGWMGMAAIAISIGGTFTIAYGDTTVEHAGGDEAIGASRLLGNVIACFGAVAFGLYEVLFKKWACPSGPESQQSSLPLTLSASALTGAYTLGILWVVFLPLHFLGWETFVVPNADEWLWIAIAVLAGAIAMTLLAILVIWTNPVFASMANVLSVFFVALADWMLWGIAPSLATYIGGILIFVGFGLLSYETLSESAHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMZ0</accession>
    <name>N1PMZ0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_24352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMZ0"/>
    <dbReference type="HOGENOM" id="CLU_1796434_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="144" mass="15196" checksum="CFDB33F89B3C27C9" modified="2013-06-26" version="1">MTLLLWTTNGYGYRIACGAALLRNDIGSPTFAAGISECLPLFDQIVRYLGVQHSAAPRQCIFESSEDAVTTYGNLITFAGRIILEETTTTSSSVSATSTSSVISIDDPYPPIPLAYTKTATTNSTPASVSITSSTGNLYISVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMZ7</accession>
    <name>N1PMZ7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_173177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMZ7"/>
    <dbReference type="STRING" id="675120.N1PMZ7"/>
    <dbReference type="eggNOG" id="KOG4174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035438_0_1_1"/>
    <dbReference type="OMA" id="DSRHYCF"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="52"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="278" mass="31615" checksum="57E3557DB13132E0" modified="2013-06-26" version="1">MAKNKKRKLHNKSQASSRSHSQPLKAKPKDTQKKQQRSSLIVPFEPASDRILLIGEGDFSFAKSVVEHHGACDIVASCYDSKETLFEKYDPQAEEHITYLEEEGQTILYNVDATKLATNKALKRNGEHFDVVMFNFPHVGGKSTDVNRQVRFNQELLVKFFTTSTSLLSQSGTIVVTLFEGEPYTLWNIRDLARHSGLEVVRSFKFRAEAYPGYSHARTLGNVDGGGGWKGEEREARSYVFRKQVEDKSGVPLRQQQLREQDKKKRQRDEDSSSDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN38</accession>
    <name>N1PN38_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_70787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN38"/>
    <dbReference type="STRING" id="675120.N1PN38"/>
    <dbReference type="eggNOG" id="KOG1844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020879_0_1_1"/>
    <dbReference type="OMA" id="RPRYMNP"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="92"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME44846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="575" mass="62245" checksum="64B51DC5ECE8AF9F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNC1</accession>
    <name>N1PNC1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI-anchored cell wall organization protein Ecm33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_72039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNC1"/>
    <dbReference type="STRING" id="675120.N1PNC1"/>
    <dbReference type="eggNOG" id="ENOG502QUZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035846_0_1_1"/>
    <dbReference type="OMA" id="WANNITF"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12454">
        <property type="entry name" value="Ecm33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109982" description="GPI-anchored cell wall organization protein Ecm33" evidence="7">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME44418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="40290" checksum="6F693C01651C7FF2" modified="2013-06-26" version="1">MAALRYIVPALAVAAGAAAQSCGGGSSTTTISSNADATALASCQTYSGSIAIATGTTDSIQLTGLQSITGSLVATNVTQMVSLSASSLEEIGEMFELEQLTILSTLSFPSLKKVNAIQWTALPALQQLSFADGVEEVGSLIIDNTQLNTLDGINLQVVDELSVTNNPYLTDITMQLGNVTKSFLLASNGRDLKVELPNLEWANNVTLRNCSEVSIPSLASINGSMGFYNGGFESLAAPNLTNVGGSLSFVSCEAVTNISMPQLTTIGGGFQLANNTALQNIDGFPAMATVGGALDFNGEFQSVDLPALKDVRGAFNLQSTQDINSVCSHFKPLSGQNNVIKGTFTCSTTSTPGGVGSSTSSGSKSSTSSGAANPMLIPGATGLLGVLAAIFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPZ5</accession>
    <name>N1PPZ5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_71247</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPZ5"/>
    <dbReference type="STRING" id="675120.N1PPZ5"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_2_1"/>
    <dbReference type="OMA" id="CLEVHGD"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="9">
        <location>
            <begin position="178"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="382"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="422"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="463"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="503"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="543"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="583"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="661"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="751"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME45462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="782" mass="86584" checksum="983780E9C5DA81A0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR09</accession>
    <name>N1PR09_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR09"/>
    <dbReference type="HOGENOM" id="CLU_2740001_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="71" mass="7981" checksum="2CDAFF2BA7091CA0" modified="2013-06-26" version="1">MICRQFRAVSMEKLSAYHKRRKDYSRTTGSGYGDVPGVRPSKEEGLASTELNAAMLAKHLFGAPRPRKTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRQ8</accession>
    <name>N1PRQ8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="9">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_51693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Endoplasmic reticulum membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PIGW family.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRQ8"/>
    <dbReference type="STRING" id="675120.N1PRQ8"/>
    <dbReference type="eggNOG" id="KOG0411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020802_1_0_1"/>
    <dbReference type="OMA" id="GLYVMQP"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME46131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="542" mass="60133" checksum="FE812BF1BE315191" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS92</accession>
    <name>N1PS92_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_43609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS92"/>
    <dbReference type="STRING" id="675120.N1PS92"/>
    <dbReference type="eggNOG" id="KOG2593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035744_1_0_1"/>
    <dbReference type="OMA" id="DAIKWKV"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME45230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="449" mass="50055" checksum="80B305CA361931E4" modified="2013-06-26" version="1">MAELATELIRTTVRALYNTEHILVIDALVVHSTLSDHDLATVLGVQPKQLRRSCGRLKEDGLLSVQTRQEKRTDGTSGYMMQPGKERMTNRDWYYLNYHRAIDSIKYRMYKLNKHVESLGAPTTEKKDLNCARCKSAYTYLEASDSLEQSTGAFICKRCGAELEPIEEEERANENESMKRLNLQTAKLTSLMQQIDSASVPENDFQAALSKQKKIERTDANPGSRTETVDVPKGGSLQSSKGIEIQPEKIAVQVQDDEDVKREIAEKDEAAKREREARQNALPEWISKSTITDNMTVVGAKEAAERKAREVHAGGASREDGGEKKPDAGRRDDVMADYWAQLAAEKEKEAQQTREEEAEEEEADDDEDDDFEFEDATGMNTPANNDTTTGMNTPVNVESSNATDDERDAKRPRIESVSNGANGTNKAAADTPAASDEDEDDMDFEDVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSH8</accession>
    <name>N1PSH8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSH8"/>
    <dbReference type="HOGENOM" id="CLU_1777387_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110095" evidence="1">
        <location>
            <begin position="36"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="146" mass="16298" checksum="2AD53D85625A0FEE" modified="2013-06-26" version="1">MAELPLAASGAIMRREASMVWVCWALLGLIEGSAAQFCSQQAGYVESDLDKLRNSFEIERVFYADCTRQRTDLQYGTHVDASLIAFIPIMANWKSTTQVKSLDCSVRGRNTHRCCTTVKHIDKVRKCCCNAEHSVRARPATAHTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTA0</accession>
    <name>N1PTA0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTA0"/>
    <dbReference type="eggNOG" id="ENOG502RHEC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1448319_0_0_1"/>
    <dbReference type="OMA" id="FATAWCP"/>
    <dbReference type="OrthoDB" id="5181940at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22792" checksum="842767CABD08BEDA" modified="2013-06-26" version="1">MTAIKDAALYDDVAAIKALIKAFFDRVNKNDPKGLQQLFVPAAHLSILRQQPDRAPPEASQWSAALQPAAQSITSSAEKITTVYQDSIEAFIKLVEDGNKRKDPKKPWPKIDEMPDLDATDVKVDGLFATAWCPFSVFFDGVLHHYGTFVYTFGKDRQSSGGSVTEKDFKFETLLQKYTRTPGWGGDSPDLFGGDAREWEQMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTI0</accession>
    <name>N1PTI0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_42812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTI0"/>
    <dbReference type="STRING" id="675120.N1PTI0"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="OMA" id="DWSWEYA"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="11"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME46268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="346" mass="37324" checksum="6EF746D64E9ACBA2" modified="2013-06-26" version="1">MRAVDVRNGTGPASSLFINPDIPRPQPKATECLVKVRAFGLNRADTLQREGKYPVPPGVTHIMGLEVSGTVEEVGSDTSGEAFEKGDEVFGLTYGGGYAEYLAASKKMLLKKPAELSWEECAGIPEVWMTALQALRLVGEWSPKMKSILWHAGASSVSIAGIQLSLSLSPNPKVYATTRQDAKCEFVVHQIGATAAFNSTKSYPKADGSIGGSWADEVRRANGGEGIDLVIDYVGAPYFADNLAVVARDGRIVQLGMMGGTLLPEKTDISAFIMKRASFVGSTLRSRSPKYQGKLRDLFAEEVLPKLVSGAYKMPLARVLSWKKIEEAHLLLEGNKTMGKLVCVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTQ4</accession>
    <name>N1PTQ4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7514 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_125478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTQ4"/>
    <dbReference type="eggNOG" id="ENOG502SNYF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087054_0_0_1"/>
    <dbReference type="OMA" id="QVINTHF"/>
    <dbReference type="OrthoDB" id="5420895at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611:SF2">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7514" evidence="2">
        <location>
            <begin position="40"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="271" mass="30802" checksum="704F3F924CA95318" modified="2013-06-26" version="1" fragment="single">MASSSAETDIREQGDAAENARRADVHEKDVEEREAYEYWGYLFKADKTGTDKLKSLLRGLKDAMNAKYEPSDQPDLTPSQLASFYRDLHGNYDQLFLGTPNESIAFIYKSLGCLHSLQPPAYTHASAFTDPAVPALKTEGWIMWQTIQLLLGPEEHAAFLREAVQIFDVKDHDTGESFPKILPRQCFPLGPDKHMVAWYEGVSERLRREAEDEEKHKQIEVEHEPEIFSDEEGSVDSRGPALAYFRNPLYRHVDGRPSIVRSHSKRPALSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTU0</accession>
    <name>N1PTU0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_70690</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PTU0"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_6_1"/>
    <dbReference type="OMA" id="MVGYCAQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001577">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="947"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1012"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1088"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1112"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1200"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="317"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="675"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="949"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1286"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="406"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1504"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1511"/>
            <end position="1525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME46797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1525" mass="171324" checksum="2321291BC3418A71" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTV0</accession>
    <name>N1PTV0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Luciferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_149359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTV0"/>
    <dbReference type="STRING" id="675120.N1PTV0"/>
    <dbReference type="eggNOG" id="ENOG502QSR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022256_0_0_1"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="11"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME46881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="489" mass="54094" checksum="D26B490D0D1A2466" modified="2013-06-26" version="1">MCSGHQSPGLWRHPSDRSSKFNDIEHWIELAQLLERGHFQGIFIADVLGGYDVYDGPQNLAPAIKSGAQWPVNEPLSVVPAMAAATKSIGFGVTVSTSYEAPYHLARRLSTVDHLTKGRLGWNVVTGYLDSAARNLSNGVDEKNMGHDERYERCEEFVEVVYKLMNASWRSDAIKLDREKGIYTDPELVRKINHKGKHFAVPGPHFCAPSPQRTPVMYQAGTSKAGKAFAARHAEAVFVSQHSPAAVRKNVDDIRRQASDLGRDPASIKVLAKFCPVLGRTQEEADAKYADYIQYGDHEGALALFGGWTGVDMGPYGDDEELRYVESNAIRSYIEGLISVAPDVNGGKWTKRTLAEHIMVGGLGATCVGTASKVADEMERWVEEGGVDGFNIAYALMPQTFEDVIEMLIPELRERGLFWEDYHVPGGTYRENLYEQPGVKEPPISHPAGKLIWHPAEHESRGSHDRVDGAVRNQDVSGDIPGWVLESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTX4</accession>
    <name>N1PTX4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_78965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTX4"/>
    <dbReference type="HOGENOM" id="CLU_1786802_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="145" mass="16700" checksum="23FCB55D910F3517" modified="2013-06-26" version="1">MSEARERASGSCQSDIQGSHLRRIDEVIIANSEKRNAKGDGSQVNKIRKRRRRKTDLVWVQSTAYRSCEPNPRHAEDNLKRQWQSQAELMGDLPTEPTPTRSATDQETSQRCASRSGFMSQRILWSDQRPNAPNTMRHPRMCFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU23</accession>
    <name>N1PU23_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME46956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU23"/>
    <dbReference type="HOGENOM" id="CLU_3050292_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="54" mass="5958" checksum="68FCDF379C216CA6" modified="2013-06-26" version="1">MRLAVWGCCMAWPYKAVDVVLPGIEYIGLIDASIIATEEAERSVTFRGISIKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU84</accession>
    <name>N1PU84_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_70102</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8 9">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU84"/>
    <dbReference type="STRING" id="675120.N1PU84"/>
    <dbReference type="eggNOG" id="KOG1113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018310_0_1_1"/>
    <dbReference type="OMA" id="SQTRCVG"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097271">
        <property type="term" value="P:protein localization to bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010603">
        <property type="term" value="P:regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12098">
        <property type="entry name" value="DD_R_ScPKA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 9 10" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="206"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="337"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="50"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME45974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="456" mass="49991" checksum="7AD86C26ACBB6355" modified="2013-06-26" version="1">MSLPSDFTNELNALSRQVLKEHPKDILQYCANFFQRRLESQRAEFLLSQAHSSQPGTVESNFPGSNPFGTTSTSSQNQLQGAGGMHSVAEEEEHDFQSPTASSFPPHVRDTSPGSPAHANSAPGGTFGDFGFGTPNDSRSNAPAATGSMEQPQSFPSNYNMGRRTSVSAESLAPASADDSNWKAPSYPKTQEQVDRLREAVSHNFLFSHLDDEQSAQVLDALQERKIPAKDVRVIVQGDAGDFFYVVESGNFDIYVSKTGKVESGVDGMGSKVAVSGPGTSFGELALMYNAPRAATVVSTEPSTLWQLDRITFRRILMDSAFQRRRMYESFLEEVPLLKGLTPYERSKIADALESTKYPAGSEIIREGDVGDRFFILESGEAYAAKRGQENRPLKTYTHGDYFGELALLEDRPRAASVLSKTEVKVATLEKDGFQRLLGPVESIMRRDDPRTQGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUE7</accession>
    <name>N1PUE7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_70110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUE7"/>
    <dbReference type="eggNOG" id="ENOG502RM6J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029458_0_0_1"/>
    <dbReference type="OMA" id="FWASERI"/>
    <dbReference type="OrthoDB" id="2788050at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="99"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="734" mass="81855" checksum="9F399BBCE2F97933" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUY8</accession>
    <name>N1PUY8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_166018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUY8"/>
    <dbReference type="STRING" id="675120.N1PUY8"/>
    <dbReference type="eggNOG" id="ENOG502QQIZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050414_0_0_1"/>
    <dbReference type="OMA" id="WEPESTF"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME47182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="334" mass="37273" checksum="6C04F1C17420DCF0" modified="2013-06-26" version="1">MAPVALQHRRTHNLLLISKLLNQRDAASPFTLVLDSLEQSGKPLVGEYLRRANVSRVQVIFVSFETLRKPESADVFIEAWKQNLSTWQMEIVQCLKNDPSQRKLLIFDTLNPLASTHSSSLAALLSSFIGPSNSLLALYHADVPVSSPQPRSENPYAPTAVTLLRYLATTIFTTHCLHHILAKKAARSRSHAEPAFGLESGIEGILQFFGANESDGIVLEMEHRRKSGRGVREWYFMPRHLLATAPVSQAGRLKETVTLLEDHPQYRTPEESAVAESEAEADTTFELGLTEKQRMDREGVVLPYFDAQKGGGNGGRILYDMGSEDDFDEEEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVQ4</accession>
    <name>N1PVQ4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_166539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVQ4"/>
    <dbReference type="STRING" id="675120.N1PVQ4"/>
    <dbReference type="eggNOG" id="KOG2520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_347807_0_0_1"/>
    <dbReference type="OMA" id="VPRCGPK"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF62">
        <property type="entry name" value="XPG-I DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="2">
        <location>
            <begin position="189"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="811" mass="89703" checksum="DACC5CFDA60A4BC0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW68</accession>
    <name>N1PW68_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_167089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW68"/>
    <dbReference type="STRING" id="675120.N1PW68"/>
    <dbReference type="eggNOG" id="ENOG502QT5T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004060_0_0_1"/>
    <dbReference type="OMA" id="SGHAITQ"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060172">
        <property type="term" value="P:astral microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="290"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="558"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="801"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="867"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="868"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME47761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1156" mass="125955" checksum="575C0B546DDF225D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW80</accession>
    <name>N1PW80_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_69246</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">SNARE required for protein transport between the ER and the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the BOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW80"/>
    <dbReference type="STRING" id="675120.N1PW80"/>
    <dbReference type="eggNOG" id="KOG3251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078260_1_0_1"/>
    <dbReference type="OMA" id="FCWLVIH"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000054">
        <property type="entry name" value="Protein transport protein BOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="110"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME47228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="263" mass="29591" checksum="CD5703D878CC02C8" modified="2013-06-26" version="1">MSALYNSALRQSKAIRADLDTLASGSSPSTTALQGQITTSITSFSRTLDDYQRSVNDELVPEKATKGKDRITNFRSELLEFRSRFAELKHEREQAQVAQNRNDLFERRPHATQTPENPYADAAISSSSGTGHNVNPLFRTTNPNFQPGQNGPNSYSSYQSPYGLGADQARESHALRENNFFGSSNQVLDEYLERGRDVLANLGDQREMLKGTQRKLYDIGATLGISGDTIKMVNRRAKQDKFIFWGGVVVFILFCYFVLMWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW86</accession>
    <name>N1PW86_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW86"/>
    <dbReference type="eggNOG" id="ENOG502RNTH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609868_0_0_1"/>
    <dbReference type="OMA" id="AILCMAT"/>
    <dbReference type="OrthoDB" id="10420317at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109139" evidence="1">
        <location>
            <begin position="22"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="390" mass="40254" checksum="43F4EE77B0548699" modified="2013-06-26" version="1">MMLRHGLTNVAILCMATVFWAQTTGSTQALCADVTDSVSGCLNKPPTSAINFCSSYLAVPTATVRLTTTVSPTSTVTRSVPTITRTAATSTFTATRVTTVSVVQTSRSIVTVLSTATTTIFSSTSSPRCLAPTIVAAASSISMASGTSPASASVAKRQASTLSEPQCLTRFPSGTALSSACSCLRPQVTAKTTTTTVTVTRPAVTITVTQTSATITVTPSTTRTLTSTSTVSSATTVLTTTTAVTTSVRNLPPTLSIVAMGGGIDGLYAIAGNMSDDTTEFSGTSSTASIFDLDSNSYLVQESGAIGYIANQSPSPNIPVVYWDDPDTVQNTDGYEPLTCSIVHSADGTCPMSCNGVNGTQNNYCDNFWYLGWPDGAPCSNAFNIYAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWG9</accession>
    <name>N1PWG9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_69628</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWG9"/>
    <dbReference type="STRING" id="675120.N1PWG9"/>
    <dbReference type="eggNOG" id="KOG1385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010246_4_0_1"/>
    <dbReference type="OMA" id="WTCRIKE"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="303"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME47747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="580" mass="63264" checksum="77AF993989B4B50E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXF9</accession>
    <name>N1PXF9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_69573</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXF9"/>
    <dbReference type="STRING" id="675120.N1PXF9"/>
    <dbReference type="eggNOG" id="KOG1148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_1"/>
    <dbReference type="OMA" id="TWCIYPM"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000015">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="66"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="233"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="462"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="13">
        <location>
            <begin position="573"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME47663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="695" mass="77886" checksum="EFD76EDF65FD5D20" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXL9</accession>
    <name>N1PXL9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_69620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXL9"/>
    <dbReference type="STRING" id="675120.N1PXL9"/>
    <dbReference type="eggNOG" id="KOG3114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059606_2_1_1"/>
    <dbReference type="OMA" id="VFRRCVA"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="97"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME47738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="295" mass="32445" checksum="AA940A2A02C5AC3A" modified="2013-06-26" version="1" fragment="single">MSGRQGYDVVVDVDADAEGDLGHTDLNDDLEFHNSTFDSNNNNARNKIPADSQNASFLNPSRQPSSSSKRYLWSIAFYQQFFDIDSMQILHRCRSTLYPRQNFLDVMEGNPDLYGPFWIATTVVVILFLTGTISQYLAYQGKDHFAYDFRLLSGAAGLVYGYLIFVPLGLWGVLKWFGSESSNLLECWSLYGYANLIWIPVALVSWSNISALNYAFVGAGLAYSGLFLFRNLYPVVSATDAKTSKALLIVVIALHAGFAIAIKVLFFAHGSPAAKSKAPAPDAGEGDAARVLFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXR1</accession>
    <name>N1PXR1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_161770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXR1"/>
    <dbReference type="STRING" id="675120.N1PXR1"/>
    <dbReference type="eggNOG" id="ENOG502RWZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_3_1"/>
    <dbReference type="OrthoDB" id="3629193at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49566" checksum="0B3F8FE1E73D3E09" modified="2013-06-26" version="1">MEDIVLADRPASRVWVMQEATLATKATCMIGTETVPLVKILRACMWLQYKGPFVTLDVLSSRGWQVCTHLWDYADHEYGYYGANANRPGSEIACALGLARRLDCSKPVDKVFGTLGLMKCTRAVKYLPADLMPDYEKPVAIVYRDATIYALQEDGVGEVFRYIKPTSREELEDGIWPSWVPRWDKPWGTDEPHDFMSTFCPDGDVMRRRLTRPEPDKSPDILRVRGIRVDTIEKCSASLPSLHLIFPAILIRWIQDAIRMNAVKNVSLSLQSHDTHTGAGRARDAAYQTSFDSDFQCTLIAGRNRLSQRPSDHDLDGLNQYVSYLTKLRDFPPDVEDLLPDASDHEQRASQYEALFRKACEGRRFIVTAEGRIGIAPGLAEEGDIVVVLWGGGTPFVLRPRADGMFLILGQCYVHGIMDEEAVKEWKEKGGRDEVFRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYD2</accession>
    <name>N1PYD2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_123593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYD2"/>
    <dbReference type="STRING" id="675120.N1PYD2"/>
    <dbReference type="eggNOG" id="ENOG502S247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040578_0_0_1"/>
    <dbReference type="OMA" id="VHKKYDR"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="95"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="307" mass="33171" checksum="C644E5EB0F8E906F" modified="2013-06-26" version="1">MFSSLKHKFSRKNDNSIERGGSVKAHSNTTPQPQQHTRPATRRPAPAAINAAKDPGDAPPAYSPAPNAAPIPPVTVSAPANQGADDPYAFLTTFDTIFLIDDSGSMAGGRWRETGEALETITPICTAHDADGIDIFFLNHRGSDHHHNITSSSTVHEIFQTVRPGGGTPTGQRLNTILKPYLRRLEASPDNTKPINIICITDGEPSDDVESPLIAAAKKLDKLDAPAWQIGVQFFQVGRDEEAKKHLKQLDDDLAEISGDDDLRDIVDTVPFTSAEGTHLSGDGILKVVLGAVNRRLDRKKSTDLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYR9</accession>
    <name>N1PYR9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vesicular-fusion protein sec17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_67628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYR9"/>
    <dbReference type="STRING" id="675120.N1PYR9"/>
    <dbReference type="eggNOG" id="KOG1586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046329_1_0_1"/>
    <dbReference type="OMA" id="WSVKEYL"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME48651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32619" checksum="F6F32E15EE290062" modified="2013-06-26" version="1">MAQDPRALLQKAEKAAASASGGFSLFGGKTEKLENAVELYTQAANAFRMQKSGKEAGQAFERAAEIQSGKLSEPDDAANTLTEAYKAYRTNEPEDAARVLEKAINHYTSKGNFRRAATHKQNLAELYEVTLGDQKRAMVAYETAAGWYETDNAEQLANKLYLKLADIAALEADYLKAISNYERISKSAINNNLMKWSVKEYFLKAGICHLASGDMVAVNRALDSYRDLDPGFTQTREHQLLVDLAEAVDEGDQEKFADKLFQFDQMSKLDKWKTTLLLRVKETIEGKEEDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYS9</accession>
    <name>N1PYS9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_31978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYS9"/>
    <dbReference type="eggNOG" id="ENOG502RYBC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_1_2_1"/>
    <dbReference type="OMA" id="VTWKCNA"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF2">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="262" mass="29480" checksum="4F98146A41B4B445" modified="2013-06-26" version="1">MSQAQNSPDLGKAVDATPCAIPDNSTALTGQFVTLEGVDRSHLQSLHQNLDLPNNSDLFNYLPWTVPGTAEDLWNILTDLEGERGFVVYAIKASLEHLNHQEKTHGSRPKHNDIVGIICYLEIHHQHRDIEIGGILFSPALQRTAAATEAHYLMLKNVLEPNSSALSKGTAPPYRRVTWKCNALNKPSQRAAERLGYKYEGTFRKHLIVKGRNRDTTWLSLLDDEWLAAKEALEKWLAESNFDWKGDQKQGLVDIRASIELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZ10</accession>
    <name>N1PZ10_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_42474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZ10"/>
    <dbReference type="HOGENOM" id="CLU_2622008_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="78" mass="8730" checksum="BB47183C057228DF" modified="2013-06-26" version="1">MASRIAAEKEVSNLRLEISRLAKNQSEATRQLAVLHVQNSQVSSERRRLGAYGGLILNLIVVCCVFVLLLFAGWNRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZD6</accession>
    <name>N1PZD6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_21351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZD6"/>
    <dbReference type="STRING" id="675120.N1PZD6"/>
    <dbReference type="HOGENOM" id="CLU_571101_0_0_1"/>
    <dbReference type="OrthoDB" id="3645758at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="478" mass="53490" checksum="C8CB95A87A11FADB" modified="2013-06-26" version="1">MALKGSHHHESARLSKHTTNYKDLTKADYVKLTLVVAPIPPPDTIAGACYNEEIKKLIANLPPHLRAKYPLITSSCSCHRKINDMPLSSILDVIQDEVSLNALEQWAEMGNDIFVDSVPVALLEDINAIWLKPEHFQQTFGRNPSPNCIWSFVDTKCVVCKLAHIARSGPAVTALGALIIARLRPENWKKSKRMYFFEEWLKSCVEFSYKQEPAILAMWECGTRLRAAREARKSIGEYGPRKYIDKFIAQVRSSTDGSCRTPGAGSSSGPRQIHAAPTSRPVAGPSHTIAQIDNPRTRPVRPLRSLRQEDHLKFTNAMLQQTLDDWTQTPISVSSTAPLMQPLWSPAQQDYAHFSKTFSFPNDYSQPDQEDMAPPATPEHSNAVRMAAVRREFYREAHAVSQEYNIRNPLDDEAVHETFQRFSRTSARPQGLSVKEPRNSMPISSSIYSRPQTGASCDEEAVIEMYRNGGCAGLSSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZT7</accession>
    <name>N1PZT7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_102471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZT7"/>
    <dbReference type="STRING" id="675120.N1PZT7"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_10_1_1"/>
    <dbReference type="OMA" id="KCQTHEL"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000020">
        <property type="entry name" value="DNA repair and recombination protein RAD54B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="208"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="528"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME47905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="834" mass="92574" checksum="082B81BF836AB2EC" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q070</accession>
    <name>N1Q070_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_67629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q070"/>
    <dbReference type="STRING" id="675120.N1Q070"/>
    <dbReference type="eggNOG" id="KOG4166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_2_1"/>
    <dbReference type="OMA" id="ANWYARH"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034077">
        <property type="term" value="P:butanediol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012782">
        <property type="entry name" value="Acetolactate_synth_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02418">
        <property type="entry name" value="acolac_catab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006378">
        <property type="entry name" value="PRK08617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF129">
        <property type="entry name" value="ACETOLACTATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="193"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="392"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME48653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="561" mass="60757" checksum="72CFD05011CE4D56" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0W5</accession>
    <name>N1Q0W5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_69887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0W5"/>
    <dbReference type="STRING" id="675120.N1Q0W5"/>
    <dbReference type="eggNOG" id="ENOG502QYNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007604_0_0_1"/>
    <dbReference type="OMA" id="TASINTW"/>
    <dbReference type="OrthoDB" id="2110361at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="56"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="471"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME48094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="514" mass="56000" checksum="40DC3D47F2CA1812" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q121</accession>
    <name>N1Q121_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_68228</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q121"/>
    <dbReference type="STRING" id="675120.N1Q121"/>
    <dbReference type="eggNOG" id="KOG1096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003782_0_0_1"/>
    <dbReference type="OMA" id="WLYFMFA"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000214">
        <property type="entry name" value="AMP deaminase Amd1, putative (AFU_orthologue AFUA_8G02860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000300">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="117"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="287"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="906"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1016"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1075"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="947"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="957"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1083"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1120"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME49372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1129" mass="126216" checksum="74EFDA2A3A12C591" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1M3</accession>
    <name>N1Q1M3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pathogen-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_49468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1M3"/>
    <dbReference type="eggNOG" id="ENOG502QUA2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_589268_0_0_1"/>
    <dbReference type="OMA" id="KRMNHEP"/>
    <dbReference type="OrthoDB" id="65445at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053218">
        <property type="entry name" value="Pathogen-related_defense"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723:SF10">
        <property type="entry name" value="PATHOGEN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723">
        <property type="entry name" value="PATHOGENESIS-RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="55111" checksum="B75C74FA37598E4A" modified="2013-06-26" version="1">MAVQEDDTQPQRPVQEDLKPAIPDYLATPNAVFGDEGVQWRYGRAPDYSKTRKVWAEGKRMNHEPGSLPEMVENLVKNWEVEASFKPRLSDWRTIDHEKYSFAMGGGAPQSAEHMIQVGTYNGIIAPNEYYSPENSDFASSHKTFKRMMPTFAWEVLEVYSGPPRVAFRWRHWGVMKNDYVGFNDKGEKVTAKAHGGLIDIQGVTVATVDDKVRLQDLQTWMDPLEMFRQIAPGGVVNRSVMNRKVDKEAALDLPAYTVGKNAAEAHDQRDDLPETTQSKHVLDSTGQYADAPVLHVGTMSQNHQQSISGSAVETGNSPQPAKDVAQSQSQDVWHDAQDTVPQAQSIVDTAASQGAEIVVNKPASNFHEAKYKASDGEPLASEVQDDPKEISERHTSTTPHSVYTSAVTGDEDKILEPAQRGDMVDESKDTGARDAIDDYLERSADEVHPQPKDVEKEVQPNAGEAVAAAPESDETRATFAEMSRISASECPFLMNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2F0</accession>
    <name>N1Q2F0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_84816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2F0"/>
    <dbReference type="eggNOG" id="ENOG502S3AD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042319_3_0_1"/>
    <dbReference type="OMA" id="WRANTTI"/>
    <dbReference type="OrthoDB" id="2564812at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7729" evidence="2">
        <location>
            <begin position="138"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="374" mass="40755" checksum="C463EF2AC3F99E97" modified="2013-06-26" version="1">MTTASPSCSSTRTPRAAVQPWLCYRQCWNEAIPAWCHRRRPAPGRTTSKQIHRSFSRGSNLVLALLVCLLAFCQDTKADVIYGSGDIFPRDLLFDRSEPPPLPRMLLERRQDDSSSSRPTTTIRPTGMQTATATGSFSLPRPFDTSIGNNFTATTCPTFFQSFLNNQTFRDCLPFSLLLQTSNSFFAASRSPLRLAETLDATCNVNLNTCSALMSQYAQQIQQTSHCGADLEMQNPVVTQAYNGFVSYSTLYHAGCLTNTDGSYCFSDAVANISSPSSSYIYYLPLGVRLPGGSRPACTACLQDTMAVFVTTAGNASQPLSQDYVNAAEQVQMSCGPQFVDSSVSRSAATVSSPFHSPSTGLVGVLISELKFWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q343</accession>
    <name>N1Q343_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1754-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_84974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q343"/>
    <dbReference type="STRING" id="675120.N1Q343"/>
    <dbReference type="eggNOG" id="KOG3410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098435_1_1_1"/>
    <dbReference type="OMA" id="QLSEHHD"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15103" checksum="F520A527263A6EEC" modified="2013-06-26" version="1">MPSSDYSSAVGGGLKLKGAGGVDKKKKKKKKAKEGNEKDDGYRPEKASDSNNAQTALQKALADEADGQANGKVPDADMKEYGKTEAQRRFEERRKKRLDERLQKEGVKTHKERVEQLNKYLSTLSEHNDMPRIGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q439</accession>
    <name>N1Q439_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cwf19-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_84860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q439"/>
    <dbReference type="STRING" id="675120.N1Q439"/>
    <dbReference type="eggNOG" id="KOG2477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015540_2_1_1"/>
    <dbReference type="OMA" id="FMKCLTR"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="491"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="623"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME49480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="84502" checksum="C32358F651B399A7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4N8</accession>
    <name>N1Q4N8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL33m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_59454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4N8"/>
    <dbReference type="STRING" id="675120.N1Q4N8"/>
    <dbReference type="eggNOG" id="ENOG502S7R4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_1_2_1"/>
    <dbReference type="OMA" id="TCFNVKR"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052008">
        <property type="entry name" value="Mitoribosomal_protein_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L33, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME50358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="58" mass="6686" checksum="8D047BC6AE3F55EB" modified="2013-06-26" version="1">MAKKAKSRTIAVRLISMAMTGYYKTFSRPRTHRPLSMLKYDPVVKKKVLFLEAKRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4P7</accession>
    <name>N1Q4P7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_69040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4P7"/>
    <dbReference type="STRING" id="675120.N1Q4P7"/>
    <dbReference type="eggNOG" id="KOG3406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110343_0_0_1"/>
    <dbReference type="OMA" id="CAEHQIP"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="34"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME50383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="150" mass="16368" checksum="689ECE487CDD1280" modified="2013-06-26" version="1">MSDGEEPTQEVVAADEVEVTADSSAQGGSMSVLDALKGVLKIALIHDGLARGLREASKALDRRQAHMCVLNEACEEEAYKKLVVALCGEHKIPLIKVPDGKQLGEWAGLCQIDREGNARKVVNCSCVVVKDWGEESQERSILLNYFQTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4Q7</accession>
    <name>N1Q4Q7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">DOTSEDRAFT_119670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4Q7"/>
    <dbReference type="STRING" id="675120.N1Q4Q7"/>
    <dbReference type="eggNOG" id="KOG0650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011390_0_1_1"/>
    <dbReference type="OMA" id="MRPAKGE"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="73"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="623"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="685"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME49835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="710" mass="80170" checksum="B9AC4FF81CB72CBD" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q584</accession>
    <name>N1Q584_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear architecture-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_165043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q584"/>
    <dbReference type="STRING" id="675120.N1Q584"/>
    <dbReference type="eggNOG" id="KOG2439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018240_0_1_1"/>
    <dbReference type="OMA" id="GYLHHVL"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1780:FF:000004">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor nar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="9">
        <location>
            <begin position="116"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME50079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="612" mass="65727" checksum="6F12E5CFB524CF51" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2WIZ9</accession>
    <name>M2WIZ9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_83585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WIZ9"/>
    <dbReference type="HOGENOM" id="CLU_427003_0_0_1"/>
    <dbReference type="OMA" id="WADYCAN"/>
    <dbReference type="OrthoDB" id="10421064at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="641" mass="70734" checksum="97E592EF9D2DA978" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2WLQ8</accession>
    <name>M2WLQ8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_132699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WLQ8"/>
    <dbReference type="eggNOG" id="ENOG502RN08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2284062_0_0_1"/>
    <dbReference type="OrthoDB" id="3763505at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="102" mass="11317" checksum="C019DF0DAF57FD57" modified="2013-05-01" version="1" fragment="single">QKTYNTGDSHVVTHRSTSPAVNCLYMGERTGSLILSYLWSYVLVTTKSKLILIRRIDVLLYPGLNHSERQNGLGVQDGYIMVIGKPPEGHGDPPCVRAHLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2WLU5</accession>
    <name>M2WLU5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WLU5"/>
    <dbReference type="STRING" id="675120.M2WLU5"/>
    <dbReference type="HOGENOM" id="CLU_004184_6_0_1"/>
    <dbReference type="OrthoDB" id="3650339at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="56"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="194" mass="22868" checksum="3C3333E60E6AABEE" modified="2013-05-01" version="1">MESSPAHLMLYQTAHLRDPRTHLRLLRFHRRTRHWASGDYLSFDLALHEMVLLPKYQAVWYDWTTGTRQETIFVNSITLKVQKNCYYALWQLWRSGAECVWIDSICIDQHNDDEKSGQVAIMFEIYHYASQVFACGESSDKCSNRVIRGLPNVDRIPEGSNRGYGEINKMVFQQMCWKWMLVQGDNYCTQLCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2WLZ8</accession>
    <name>M2WLZ8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_80593</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WLZ8"/>
    <dbReference type="STRING" id="675120.M2WLZ8"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005733_1_0_1"/>
    <dbReference type="OMA" id="IRRSNCC"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF18">
        <property type="entry name" value="NICOTINATE CATABOLISM CLUSTER-SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME43068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="852" mass="95760" checksum="BBFEFB4D9BDC76BA" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2WN14</accession>
    <name>M2WN14_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Striatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_72705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WN14"/>
    <dbReference type="STRING" id="675120.M2WN14"/>
    <dbReference type="eggNOG" id="KOG0642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009046_0_0_1"/>
    <dbReference type="OMA" id="SKCSQEV"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="5">
        <location>
            <begin position="29"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="750"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="574"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME43393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="829" mass="89545" checksum="7F55F81E3F05F7C0" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2WNS8</accession>
    <name>M2WNS8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_72879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WNS8"/>
    <dbReference type="STRING" id="675120.M2WNS8"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_11_1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="267" mass="30516" checksum="9A38A648ED9688AC" modified="2013-05-01" version="1">MLQRMFPNGKVPKEVVAHIVQRLLACVNWLFCDCDIIHTEITAQNVLLELSDAEHFRTIEEEEAVEPSLPVYDGSYPVYLSRGNTVSMLQLTLDPVLTDFGSSRSALEVNKDWWMPDTHRAPEILMDVAWDAQVDVWSIGIMALELLEGRNLFHPVDKARNQYVLPLAVSQYISYMGLPPLWMIQQSNNPIIKTFFDVEGNWIAEPPIPEASLDNFVTTIESCKEKALFLDFINKILQWDPVKRGQSAHLFCHEWLAGPETDSMNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2XIU3</accession>
    <name>M2XIU3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_100849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XIU3"/>
    <dbReference type="STRING" id="675120.M2XIU3"/>
    <dbReference type="eggNOG" id="ENOG502S6PD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038384_0_1_1"/>
    <dbReference type="OMA" id="LYFGMWY"/>
    <dbReference type="OrthoDB" id="4838853at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="266" mass="30714" checksum="0641A714E75F5F44" modified="2013-05-01" version="1" fragment="single">RPPPLNYSLWDRKWFIAFFWGLILIDVIAQPLALYFSLWYYTNLSPNTVFSIITAALGGVSIFEYVLRFWRLWKKNSTCRVLGARRWYLDWFHWNFSAGWIIIMIELIVGTIPTNPPIRLLAMPLASMLFTFGIEMLVVDTLRYFQVPAPVRISSIPKGAQLRPAIYSLIEDIIATDGSGGTAFREALNKRYETSHVFRAMLRRLGAFWMVGANAMAVATTILIFTIQHEAAYCVGWSAPFVWAGIWTLATIWYVKRKLREEQTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2XK09</accession>
    <name>M2XK09_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_173274</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XK09"/>
    <dbReference type="STRING" id="675120.M2XK09"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OMA" id="EDQYTIT"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="131"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME42827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="570" mass="63913" checksum="439FF6BBAFBA16D8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>M2XM81</accession>
    <name>M2XM81_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tfc6</name>
        <name evidence="9" type="ORF">DOTSEDRAFT_72812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XM81"/>
    <dbReference type="STRING" id="675120.M2XM81"/>
    <dbReference type="eggNOG" id="ENOG502SH73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007091_1_0_1"/>
    <dbReference type="OMA" id="VYNQEMR"/>
    <dbReference type="OrthoDB" id="4236860at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME43562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="774" mass="85967" checksum="6EA338EB734A6BFB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2XMA6</accession>
    <name>M2XMA6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mei2-like C-terminal RNA recognition motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_105962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XMA6"/>
    <dbReference type="STRING" id="675120.M2XMA6"/>
    <dbReference type="eggNOG" id="KOG4660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122513_1_0_1"/>
    <dbReference type="OMA" id="QANINHY"/>
    <dbReference type="OrthoDB" id="417481at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mei2-like C-terminal RNA recognition motif" evidence="1">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="113" mass="13562" checksum="0E39CF03836B90A4" modified="2013-05-01" version="1" fragment="single">MDVRTTVMLRNLPNKWGVREWKAMLDAYTFGMYDFSYLRIDFGNSYNVGYGFVNFTESKHIGRFLDRWMGQEWEPGHRPEKRVQLSYATVQGYDCLVEKFRNSSIMEEFEGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2XMB3</accession>
    <name>M2XMB3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_72829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XMB3"/>
    <dbReference type="eggNOG" id="ENOG502TD8V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_6_4_1"/>
    <dbReference type="OMA" id="EANTMFR"/>
    <dbReference type="OrthoDB" id="5342292at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004028895" description="Rhodopsin domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="9">
        <location>
            <begin position="126"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME43592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="434" mass="48977" checksum="D06C906E0F5E1F01" modified="2013-05-01" version="1">MRVLWFCASLVGLCQARHPLPESNKADGNLQVTANTTHGLAACTQQCLEQQSRPLVCTYKAVFDSSMTKCVQTTCPTLTDLFAWETRYAQQCGLKARDEGVGELVIAYVLFGLSTLSLVGRLLSRSRWLDGPGYWWDDWTVMAIWVLSIEMAVCPISSRVHWTGRDAIDFVTPHDIEQVLLWTYISEPFYLIATFGSKLVWVLLYLRMWEANTMFRKLCWITIVALTLAMVGYPIGAIITFWPHKFYIGESAIVRQDFRGIDLIPTVIAIGVQIVLFDFWTLLLPIPKLIKLTGVSKRKRASICAIILLGFVVTGCSIARLTVVLPLRDSRNPNWDIGHFGTWSEIELHLSMITCNLPAMAGLVHRMVSRRARHTTIRSESEFEDSEVSPDSESLAAKTGRSVDIEDGSTFEAELVEDEHGKIVMRKKKREEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>M2XZT7</accession>
    <name>M2XZT7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_48822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XZT7"/>
    <dbReference type="HOGENOM" id="CLU_1906679_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="133" mass="14451" checksum="470BF25C51DF55E9" modified="2013-05-01" version="1">MSTATYPDLDSAVLVQRTSASHDLLREACPLSAVCSRTSCGAASSSLGLSVVYLAWLLEVSERPEEVGGSLLSLPTRSDCCRKISPHIFEAVPERRCVWLENSRQSIPRKHQNCGQYASLLTTTQLGCDGHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2XZU1</accession>
    <name>M2XZU1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_57700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XZU1"/>
    <dbReference type="STRING" id="675120.M2XZU1"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_1"/>
    <dbReference type="OMA" id="TFRGYYR"/>
    <dbReference type="OrthoDB" id="3633556at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05926">
        <property type="entry name" value="FACL_fum10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045310">
        <property type="entry name" value="Pcs60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="429"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME38193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="524" mass="56587" checksum="D33274A96995CFF4" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y004</accession>
    <name>M2Y004_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_75424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y004"/>
    <dbReference type="HOGENOM" id="CLU_2638040_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="77" mass="8414" checksum="475792852B33129E" modified="2013-05-01" version="1">MLFELANHSTVLLNPIIDSELNVCDAALADAYKTPADDDPDPKIFQCEPTETDGGLPVKWNSGIRYVALPQSLQHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y0K5</accession>
    <name>M2Y0K5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_75531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y0K5"/>
    <dbReference type="HOGENOM" id="CLU_2291616_0_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="101" mass="11612" checksum="D25C2E87FB45F677" modified="2013-05-01" version="1">MDPAVDPTREPLEDWSSLLGADGRPLPRLYQDIFSLDYPDFLAFLGTSQLPQVQRMKTHVDAHHRLLCEIARTGELANTNQRNNRDWYTWCDEAAGIDLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y1X3</accession>
    <name>M2Y1X3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_75131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y1X3"/>
    <dbReference type="HOGENOM" id="CLU_1547542_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="173" mass="19286" checksum="950D41DC0A512F54" modified="2013-05-01" version="1">MGVKSLNCSIRGASRRLDISEQCVFSRCTSAFIGPVVLRLGATSSEANEIQVDDLTFAFRVHPSLIIRHRRFRLRFSARTRVERRSVAKITFIGTSSFGAQCVSEHEGHVDRFCSGALWQMKLDQNASSFRPVATCRATYEYATATVGQGAQVLSQNVEYREILAGLNNLHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y2E3</accession>
    <name>M2Y2E3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flavin-dependent monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mox6</name>
        <name evidence="8" type="ORF">DOTSEDRAFT_47966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y2E3"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_0_1"/>
    <dbReference type="OMA" id="VMIKEVN"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME39469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="503" mass="56903" checksum="F2E85882AB77EA8A" modified="2013-05-01" version="1">MGSLEAESRSKADSVCIIGAGPSGVAAAKYLAAERAFSRITVFEQRSRVGGIWNYVPYDEIPPEDAAVPQTNPRPGLNKPVWRHSNASDVVGQDTKEQAAFLTPLYDRLETNIPRSLMGFSDLNWPENTPLFPKHDNVLAYLEHHAEDVRHLISFNTQVLDVHEKDDGRWLVKTQEVSKDEQKVTQEHDFDAVIVANGHYDVPYIPAVSGIEAWTSTYPGVISHSKLYRKPEHYSGKKVIVVGNSASGIDIGAQIATVSRHPLLMSQKSESYLQVGASSPDKQEKPEIIEYILKDRSVRFADGTVESNIDSILYCTGYFYSFPFFNNLDPPLITTGERVENTYLHTFYRSNPSLAFTVLNQKVIPFPFAEAQAAVIARVFSGRLTLPSPGEMEDWEVQTTEEMGNGRTFHVLKFPKDAEFINMLHDWAVSVDGQVETNEPKKMGKTPPRWGEKEFWTRERFPSIKKAFQNFGEQRHQKRGLEDVGYSFEQWKKEKADTDKRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y5W7</accession>
    <name>M2Y5W7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_54407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y5W7"/>
    <dbReference type="STRING" id="675120.M2Y5W7"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_608345_0_0_1"/>
    <dbReference type="OMA" id="EICISYR"/>
    <dbReference type="OrthoDB" id="3640265at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="450" mass="51389" checksum="BDA546AEAC8D38DD" modified="2013-05-01" version="1">MTQSYEVRASPGKGYGLFATRYIPAGTLILADRHVMVIAKEGGARQDPKHDIQHAFEQLGESQIEQFLSLHAGPEDGRRLVERIYTTNRFGDFESTYMCLTISRINHACIPNAASTAGETDDEDSIRAIAPIKKGDEICISYRSDLCWIMTRVQRQALLQSWNFDCQCPLCDLPSAEIDLSDFRRKFIFALRWNTVLEDPVDLSHYDSLDFRDTEEAYDTLNEPNLEPLDSISLRTITAYQLLLAHALEAERIDRDLIGKAYYEAAIAHFADLAAMAENVLVLQWGRNVRDWMEKAIQLTSDFYGFNSDDAQQYRNDWKTMQLLPQLALLLDICDLPTTTNEPIEVQDLILQKLPTRAVHDDDELHPAFALLFLTLPGGRPAVRCIDETECRNFVREQCLLEDIRSTTIKERDAFIEQYKLVVEVRENLRSIAETEGRLNALFVEEMPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2YHV4</accession>
    <name>M2YHV4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_75968</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YHV4"/>
    <dbReference type="STRING" id="675120.M2YHV4"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="OMA" id="NFICGHE"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="191"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME38080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40483" checksum="0699827849452893" modified="2013-05-01" version="1">MSKPTTMRAVVFKGDYNVVVEDRPYPQLKNPTDAILKVSSTALCGSDLHFYRGHLKCPPNFICGHEFVGEIVEKGDAVKKFNIGDQVVVPFFTACGECYFCVRGQASRCAKGELFGNSAPANTIDGGQAEYVRCPLADSTFVKTPPGIPEEMLVLMADIFPTGYFAAARYLKDLPQRDRDEYTVVCIGCGPVGICAITCALTMVKTVYAIDSVPERLEQAKALGAIPINLNDDPVQKIKDATSGRGADVIMEVVGHADAWNMGFDMIRPWGAISSIGVHTEKWEVNGLMLYGKNVSMAFGRCPVRSIFEDALALLVQEQKKVAFLCGKTMSIEEAPQAYKDFEQRKVHKIVFKMGGKDEVKQREIKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIA5</accession>
    <name>M2YIA5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_48196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIA5"/>
    <dbReference type="eggNOG" id="ENOG502SAXA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081840_2_0_1"/>
    <dbReference type="OMA" id="TRCHIGD"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="179" mass="19063" checksum="CC6E237DF138A3A7" modified="2013-05-01" version="1">MADQTVSKISIRPEIACGLDASQIRDVIQTAFAAKSHLDHQEAEIVDSLRKSGALSISLLAFLHEEHRDTMIGHVAASPILINGVKRGWYGLGPVSVRPAHQGQGIGSALVEGSLKALQGLGAAGCVVAGSPKYYQRFSFEHDPAMTFEGAPAKSFQRIILNGPAVDGEITYHDAFKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKJ9</accession>
    <name>M2YKJ9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_138875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKJ9"/>
    <dbReference type="STRING" id="675120.M2YKJ9"/>
    <dbReference type="eggNOG" id="KOG3752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030894_4_3_1"/>
    <dbReference type="OMA" id="WIYKWTR"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME39395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="179" mass="20528" checksum="2B3F4EDA06DFB790" modified="2013-05-01" version="1">MVYKMVFHVDGGCRGNGQTGSIGAAAATLDTRYGNQHSHKTQQLSSYYHTPTNQRAEIQAVILALEWAQEKYRGLDTTPELDITIYSDSKYAIGCMTDWIYKWTRNGWTNAAGNPVANRDLIEEASDLDDWVKDRGSIQYIWIPRDQNTNADRYCNEALDEQENTQWSRTYYTDSSDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2YM84</accession>
    <name>M2YM84_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">NADPH--cytochrome P450 reductase</fullName>
            <ecNumber evidence="18">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DOTSEDRAFT_72482</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">This enzyme is required for electron transfer from NADP to cytochrome P450.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="18"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YM84"/>
    <dbReference type="STRING" id="675120.M2YM84"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_3_1"/>
    <dbReference type="OMA" id="PLQGNME"/>
    <dbReference type="OrthoDB" id="3633599at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000032">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF108">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 18 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0521">NADP</keyword>
    <keyword evidence="12 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="20">
        <location>
            <begin position="93"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="290"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EME43116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="694" mass="77073" checksum="30EBB4CDB09DE19C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2YN74</accession>
    <name>M2YN74_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_35674</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YN74"/>
    <dbReference type="STRING" id="675120.M2YN74"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_9_2_1"/>
    <dbReference type="OMA" id="SKGCWEV"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="16">
        <location>
            <begin position="406"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME43405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="476" mass="51786" checksum="D791352E31BA8FB7" modified="2013-05-01" version="1">MPTAAQDIPVRNGSSQDDLARTVSNSFNAESSLSRSPELSFHSPNQSYAGPPKVSAKQLRPFQTQDVKVLLLENVNTAGQSILKTQGYQVEALKSSLPEDQLIEKIQDVHVLGIRSKTQLTANVLKHAKNLIVVGCFCIGTNQVDLKYAAENGIAVFNSPFSNSRSVAEQMIGWIISLARQMGDRNVEMHKGVWNKVSAGCWEVRGKTLGIIGYGHVGAQLSVLAESMGMRVIYYDVINLMNLGSATQVHSLDELLQGADFVTLHVPEIEETKNMIGGPQIEKMRNGAYLLNASRGSVVDIPALVKALQAGKLAGAAIDVFPNEPGSNGEHFNTQLNEWTDDLLKQKNVILTPHIGGSTEEAQAAIGVEVADALVNYVNFGTTIGAVNVPEVALRSLTLDEPNHARVVYIHKNVPGVLRKVNEILGDHNVDKQMTDSRGDVAYLMADISNVNVSEIKNLYQSLEDLGSRIRTRVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBN0</accession>
    <name>N1PBN0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_161482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBN0"/>
    <dbReference type="STRING" id="675120.N1PBN0"/>
    <dbReference type="eggNOG" id="KOG4532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012621_0_0_1"/>
    <dbReference type="OMA" id="CCFTVAF"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="2">
        <location>
            <begin position="311"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME38502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="763" mass="84126" checksum="9012D0A714D30B45" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC70</accession>
    <name>N1PC70_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_39401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC70"/>
    <dbReference type="STRING" id="675120.N1PC70"/>
    <dbReference type="eggNOG" id="ENOG502SCKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700247_0_0_1"/>
    <dbReference type="OMA" id="YVHHEED"/>
    <dbReference type="OrthoDB" id="5335351at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="394" mass="43607" checksum="FAE3E62AA6469DA4" modified="2013-06-26" version="1">MSSAQLKSEAHTSNSSVKVKTEGLEHATTPATNAPTSSPLSFLPPSSLPPPPDMAADKKMTSSEAMPPPRDTPARKRSSGEMQEDAKSSESSQTVIPKLAQLAQQGKFEIQDIDSSAMIVPNSQIQGRLQTEQRTDVTDAPLPSSVAHSQAVPPSAQGQKPKLKAQNQSKAGSNKSKNTAKEQVKDDVIVDDENVDDDSTTTAASDDAGEPQDPIQDFDWNSLHGRYQYKMTECRHNERVILQEFGHLVDARTLRLDASVHADSSQYFHIWAQSGNAKESERSLKRLKTQEFYVHHEEDDLERKREHYTRVVAAFQIAHLLVEHSPNLAKDLVIRELAGKPSIRDKKSCLKSKATPSASIPEIMHKGFSEKTAGDIDMRKYRYRGHHASRCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDB4</accession>
    <name>N1PDB4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDB4"/>
    <dbReference type="HOGENOM" id="CLU_2333591_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="98" mass="11022" checksum="827E82A957C3E6A7" modified="2013-06-26" version="1">MWREHVMQNCCYFDDRLHDSTTPNGILWLISINSHCIAQRRPAELGSQLQSGASQAHFTSSAEVRQTRARSWLNHDLLHITEIPGAHLSVSGVTLTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDW7</accession>
    <name>N1PDW7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_37367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDW7"/>
    <dbReference type="STRING" id="675120.N1PDW7"/>
    <dbReference type="HOGENOM" id="CLU_1184987_0_0_1"/>
    <dbReference type="OMA" id="THSHAEW"/>
    <dbReference type="OrthoDB" id="3649185at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="234" mass="26452" checksum="79E4C93B09877667" modified="2013-06-26" version="1">MKMWRIKTRLERFASTVNNPEAFPGLTVTCGESSWLCRKVILCQQSEWFQRTCSGRLNEGGAATIELQEDDSEAVGAMLRFCYVAEVDFEAKDIEYVIRLFANAEKFLGQLRWSAESSDPERIVKSRIVRLILSESHLMERGNEAFDKFLATTGEIGADMTKAVVHEQQRQEQELKIKARQAAADSKRRCRCPDDVCPACVVPSTVAVNYTHQCPDGSTCIYSGSDWLRFYEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDX6</accession>
    <name>N1PDX6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_57500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDX6"/>
    <dbReference type="HOGENOM" id="CLU_1294379_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="213" mass="23350" checksum="553898AE4FE633AD" modified="2013-06-26" version="1">MHIVAIGLDEPDYHGQFTSDKALRRVSQCIYGLVLQDGKPIDIIPQDGKVRQASATKRQLSISLAQTCRQIPAGSIKMLWANFTFSFDMYAADSPNPTSTVACEVLPNSIGPSNPSAVRSIIIGSLKAPHRRFCGPTFTNFRNIASQVRPRYAFLLDRVRKRQTLAPACRIYFPTTLVLPSDGYRRAELGSVVNGGAVLFEEARAALALGLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEE8</accession>
    <name>N1PEE8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_74297</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEE8"/>
    <dbReference type="eggNOG" id="ENOG502S6CG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029871_5_0_1"/>
    <dbReference type="OMA" id="EKIPANW"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF15">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109042" description="Heme haloperoxidase family profile domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="10">
        <location>
            <begin position="95"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME40707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="425" mass="45560" checksum="B575A56A78B703FC" modified="2013-06-26" version="1">MKSFVVSSLLLSGAAAFPFVMDQPGINTNMVRAERQRVRRQQSNANGPGSAATCPFNANHVPAAPVTSQYPYNNAKNGAQGNQKGGYLVPDPNDTAHAFVAPGPNDIRGPCPGLNTAANHNFLSHDGIVTYNELVDAQQNLYNVGYDLANVLALLGLTLTDGDVETEKLSIGCDATSRTSVNPALTGSEPGLDGHNKFEADSSLTRNDYFTHGGDNYKFNGTLFGMMTQTTGGNYDLQGLAQYRYERYHQSQVENPNFYFGPFSLLLFGAASFLYELMPSGPNYTPDEATISSFFGAEKNSTDGTYSFNGMEKIPANWTNRVAPYDLNAVGSQIFAMYLLKPVPFGGNTADGTFDVINFGAIKNGTIPSSASPKDISCLMYQLLTERVPSYLNGVVTPTVDALSLVATKLSGTDFANLGCPQALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEM1</accession>
    <name>N1PEM1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_38062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEM1"/>
    <dbReference type="HOGENOM" id="CLU_1503395_0_0_1"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109048" evidence="2">
        <location>
            <begin position="30"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="179" mass="21069" checksum="CE0A2B030D29487D" modified="2013-06-26" version="1">MTPSGESSLMALCYMYAWLLLQRPPWLRARQDVRSRCRARCVRQCLRQSSRSETDHGTASVAETDDRRRARRYRGDRRRRSQIRRRRRRPDRREILQNFLHAILSRAHPELIKNTDILVHRLEAYGCVEDVMRQIARMYEPSGELGRMNVYCVGPTSHFGATPQVEAGCVGWVEELRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFE1</accession>
    <name>N1PFE1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate esterase family 12 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_90924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFE1"/>
    <dbReference type="STRING" id="675120.N1PFE1"/>
    <dbReference type="eggNOG" id="ENOG502RY37">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065859_0_0_1"/>
    <dbReference type="OMA" id="QMGHNDA"/>
    <dbReference type="OrthoDB" id="2141316at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109789" evidence="3">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="251" mass="26519" checksum="9F9E6B1B7067546D" modified="2013-06-26" version="1">MHHATSVLATTATWLIAAIAETVHLTGDSTMVATGNNDGTEGWGAFLPNYTSLAVSNEAIAGQSARSFTREGRFAAVVATIKQGDYVVIEFGHNDGGSLSPTDNGRTDCNPNDAAGYAATCQTTYNGVSETVLTYYAYLVNAAKLFQSKGASVIISSATPDNVWEGGSYSYSPSRFVAYARDAATDSGSTFVDHQNYTAALYKDLGYATVNAFYPHDHTHTSPAGANVVANAFILGLNATDSTMKKYITQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFJ6</accession>
    <name>N1PFJ6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class II aldolase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ald2</name>
        <name evidence="4" type="ORF">DOTSEDRAFT_179427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFJ6"/>
    <dbReference type="STRING" id="675120.N1PFJ6"/>
    <dbReference type="eggNOG" id="ENOG502SKYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_2_2_1"/>
    <dbReference type="OMA" id="VTDFAYY"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050197">
        <property type="entry name" value="Aldolase_class_II_sugar_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789:SF0">
        <property type="entry name" value="3-OXO-TETRONATE 4-PHOSPHATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789">
        <property type="entry name" value="FUCULOSE PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="3">
        <location>
            <begin position="23"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="321" mass="35699" checksum="6EF3FBF586ADDC30" modified="2013-06-26" version="1">MTSDDTRSALLRASKPPSKDLFSTLITANHILHYHSVVDAFGHISVRNPQNPATFFISKSLAPALVSQREDLEEYYVEDASPVNKDAPKGYAERFIHSEIYKKYKSVNAVVHAHSESVLPFAINSVPLRPVFHMSGVMGSTVPVYDIQNHYKSSDALHSLLVNNQHLGEGLANGFNPSTLTSKATSMIKNYITSSQPAPVDFPQHPTVLMRGHGFTCVASTIEECVYRAIFTCTNARVQTTALLMQGGYNQGLIAERFGLKEEQPGQAGVAKQEGLKFLSEREAKDAWTAMQRHAERPWKLWCEEVRVCGLYRNGMEGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFU8</accession>
    <name>N1PFU8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF336-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_26658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFU8"/>
    <dbReference type="eggNOG" id="ENOG502SMVS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103773_2_0_1"/>
    <dbReference type="OMA" id="VAHVRMD"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052517">
        <property type="entry name" value="GlcG_carb_metab_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34309:SF1">
        <property type="entry name" value="PROTEIN GLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34309">
        <property type="entry name" value="SLR1406 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16053" checksum="9B8DD1CCCE072B19" modified="2013-06-26" version="1">MATRSVPNLTNDAALIASQAAQDKAKSMGIDFNIALVDASLYLLHFTRMPNAKLTSIDIAINKAFTAAGHRVPTSTYTSSQAAKNFLPGGPGYSIHNSNGGKFTLIGGGLPIELDGRVVGAIGVSTGTPAQDTEVAQAGVDALNAWVKRKQGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGK3</accession>
    <name>N1PGK3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_101639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGK3"/>
    <dbReference type="STRING" id="675120.N1PGK3"/>
    <dbReference type="eggNOG" id="ENOG502S5YK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184135_0_0_1"/>
    <dbReference type="OMA" id="HRARHKE"/>
    <dbReference type="OrthoDB" id="4505928at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="7377" checksum="E96D997DB30FA378" modified="2013-06-26" version="1" fragment="single">RDNQRRSRARRKEYLSELESKYQNCERVGVEANAEIQTAARLVLADNKRLRAMLKSLGISDADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGN5</accession>
    <name>N1PGN5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_26697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGN5"/>
    <dbReference type="HOGENOM" id="CLU_1768012_0_0_1"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="147" mass="16370" checksum="286DEB794879E5B0" modified="2013-06-26" version="1">MALGRIQLPNEGRLMTLPPELRNEIYQIVLDDETQRCSTRFKVRFTSKGQVRHGREEPALLNTSSTIRAEALPMFYALNKFELTFAVGQFHGAIEWVSSLREQYGNGLQGGGPLGAISLNITTCSWSHVASLFPFAEFAFEFASVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH94</accession>
    <name>N1PH94_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_26839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH94"/>
    <dbReference type="HOGENOM" id="CLU_1540015_0_0_1"/>
    <dbReference type="OMA" id="MLIFTCP"/>
    <dbReference type="OrthoDB" id="10417548at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109097" evidence="1">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="174" mass="19439" checksum="598A4E8AE7CAECB9" modified="2013-06-26" version="1">MARFPTLFVIITAILFTTLTSATIRVYKDCTPSLRTYVADQLEAAIANIELVAKIRNKPEDRLEMQYFGILNQGQKDRVAETYARALRNRPMLIFTCPKRGSELEKICEGSLDADVADNVQKLGLSLMIRERNELVLCPAPEVGADLAFVNKLTIVSAIIEAMLEEKQASFEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHG0</accession>
    <name>N1PHG0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_26928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHG0"/>
    <dbReference type="HOGENOM" id="CLU_611144_0_0_1"/>
    <dbReference type="OMA" id="MHEREGA"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109773" evidence="2">
        <location>
            <begin position="18"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="448" mass="41088" checksum="A8EDD0B58BE9A160" modified="2013-06-26" version="1">MKYSFVLGASSLALVYAAPTYIDSNSWSNQGSVGYQKSGSAPEGYGSGYLNGNAQGGVQVSPVQGGTGAGGEIEGGAHVGGAGHVGGGLNGGGSLGGSIGAGLGGLLSPVAGILGGLTGGLGGKSGGGFNAEAGVNGITGAGLGSIAGAGVNGAGGFKFGGGAGLGGGAEAGTGGREIGSYGGNGVAGAGTHGGAGLVGGVQGSAGGVNGHGSGSESGSGSGSWNSGLNGGIRPPPAGCYPGSPHPGCQQQPGNTQTSPVSGGSLGSGSSQSGYGSGSKGVGSTGGGLAGPAPGQGGSQCYPGNSAPECQQQPGQEHPGQPEPGKTSISPVSGSASSGSGAKPPGYGSGSEVDQNGKSETSPVGSGSSDSNKGQKGSSGESEGVDCEEDGNTETSSTSGQHNGSSDVHPTAQGYGSNGSNGNTETSPVSGQQPKGGAPAPAAYGGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIG8</accession>
    <name>N1PIG8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_37222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIG8"/>
    <dbReference type="STRING" id="675120.N1PIG8"/>
    <dbReference type="eggNOG" id="ENOG502SBSU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_397951_0_0_1"/>
    <dbReference type="OMA" id="CCPYSSA"/>
    <dbReference type="OrthoDB" id="3800261at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109403" description="TNFR-Cys domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="71081" checksum="9CCCF0B443D8C99D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIJ6</accession>
    <name>N1PIJ6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formyl transferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_73306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIJ6"/>
    <dbReference type="STRING" id="675120.N1PIJ6"/>
    <dbReference type="eggNOG" id="ENOG502QVN5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008537_1_0_1"/>
    <dbReference type="OMA" id="GFDPSYH"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08650">
        <property type="entry name" value="FMT_core_HypX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047180">
        <property type="entry name" value="HoxX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388:SF1">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Formyl transferase C-terminal" evidence="3">
        <location>
            <begin position="229"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME42433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="740" mass="81422" checksum="7C4B6CEB37DF2970" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIT8</accession>
    <name>N1PIT8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_26408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIT8"/>
    <dbReference type="HOGENOM" id="CLU_1602682_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="166" mass="18552" checksum="A3A26D1D9D8A5CB0" modified="2013-06-26" version="1">MPGPIKLEDHSPAYKAYKNLGRPPLNLPPFTIDEHVRSAAIDPTASRDYGIICTIIPIRLRPNLRKNVLSRDLAKLGRFFEKLMRHEEYSGKNARSGGRARKTAMGPSAARPSCGPPSHDDDQDDEEPEVMKRETGGLNGREVMEIDSSPVPEERHTRNRPSEAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJC2</accession>
    <name>N1PJC2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJC2"/>
    <dbReference type="HOGENOM" id="CLU_2263668_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="103" mass="11432" checksum="6A6EF2445EBE4624" modified="2013-06-26" version="1">MMTEKCSHRIRISTLVLPHNANTLLGKAVRFSSCSSGHLRSLRSLRLCRQCRLPIPSWTTGTLLYSSTTTHRMAATNNNARTSTTRSCRATPSNFTAINPDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJS6</accession>
    <name>N1PJS6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_156872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJS6"/>
    <dbReference type="eggNOG" id="ENOG502S5M9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073624_2_0_1"/>
    <dbReference type="OMA" id="QGIDFCK"/>
    <dbReference type="OrthoDB" id="2142503at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109421" evidence="2">
        <location>
            <begin position="24"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="161" mass="17999" checksum="87371B08D36ADDB1" modified="2013-06-26" version="1">MARHTQIWRYTLLFLTFLSVALAATPTSFCKCTCFTNSTIIPLNGPSSSLKNNTFFSDPSPPNLKPRNDEPLFAARAPAESTKRTCNDCNKQFCLSYNLPICKDADAEKDVFATCFQRDSTKDEIVVLVFIGATVGLLAWAMVKPWWERWREGSGYARVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJW9</accession>
    <name>N1PJW9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_37163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJW9"/>
    <dbReference type="eggNOG" id="ENOG502SYG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2015216_0_0_1"/>
    <dbReference type="OMA" id="THACNCA"/>
    <dbReference type="OrthoDB" id="5178825at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109900" evidence="1">
        <location>
            <begin position="18"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="123" mass="13082" checksum="834433F3A7797649" modified="2013-06-26" version="1">MYSSTLTLLSALGLASAAAVPKAPEISKRADCVCNRNDDAGRWTDSESPAYRLQTLIVQDGGGCAYTDASQKMCVSGDVHNWGECAIQYAQEQQSQHGDWFLWSSISCGGGSDVLTITIGTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLD5</accession>
    <name>N1PLD5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">transketolase</fullName>
            <ecNumber evidence="4">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_71819</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLD5"/>
    <dbReference type="STRING" id="675120.N1PLD5"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="OMA" id="FINIHTV"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF6">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="392"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME44131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="745" mass="82372" checksum="F6C23A07E8939324" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLD9</accession>
    <name>N1PLD9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_44183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLD9"/>
    <dbReference type="STRING" id="675120.N1PLD9"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022939_0_0_1"/>
    <dbReference type="OMA" id="HKICIDQ"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="629"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="675"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="707" mass="76682" checksum="FCB60C1ACF0C3977" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLG3</accession>
    <name>N1PLG3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diaminohydroxyphosphoribosylamino-pyrimidine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLG3"/>
    <dbReference type="STRING" id="675120.N1PLG3"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051532_1_1_1"/>
    <dbReference type="OMA" id="ACDTIYN"/>
    <dbReference type="OrthoDB" id="2529286at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31616" checksum="02EF9D6052334C39" modified="2013-06-26" version="1">MAMDTILQKLGDEIVDVDEETFDVFSQSVPSRDLGMVDAKAEALELTIAGRDFEITQSPGVLQSSRGGGTTGAAVWQTSVRLAEWLAWSENPLFKYALLGARSTALELGAGISGVVPLVLRPRIKQCFATDQSYVLKALNDNVSANSKDSKAHGKKRAKPGLQSTISTFALDWENDNVTSVLTANGVELGSDLLLAVDCIYNYALIEPLVQTCTDICKMRSQKDGDGGIEAAPTICVIAQQLRQPDVFELWLQCFHRRFRVWRLPDDLLSDGLKENSGFVVHFGILRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLM0</accession>
    <name>N1PLM0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_175071</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PLM0"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_1_3_1"/>
    <dbReference type="OMA" id="TFPVEMK"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000819">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="660"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="903"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="852"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME42186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1444" mass="161264" checksum="5BCA770FB9E3C2AC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLN2</accession>
    <name>N1PLN2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_24049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLN2"/>
    <dbReference type="STRING" id="675120.N1PLN2"/>
    <dbReference type="HOGENOM" id="CLU_2291629_0_0_1"/>
    <dbReference type="OrthoDB" id="3650075at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="101" mass="11406" checksum="29E23426F7A00C9D" modified="2013-06-26" version="1">MSTLTDFTITCHDREWRVHRVVLALHSEVLVKACAPDFEEAATGKIYLSSKREDVVATLVQFLYSFDYEYGTCDPQAASSPGHLEFHVVSLSRLINSTLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLP8</accession>
    <name>N1PLP8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenylosuccinate lyase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_24339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLP8"/>
    <dbReference type="STRING" id="675120.N1PLP8"/>
    <dbReference type="eggNOG" id="KOG2700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_3_1_1"/>
    <dbReference type="OMA" id="KFVHWGA"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01597">
        <property type="entry name" value="pCLME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF2">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="2">
        <location>
            <begin position="367"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="460" mass="50666" checksum="8B3BA6E6368A91C2" modified="2013-06-26" version="1">MPVSAIDSLLFKNLFGTEEVRKIFEDKNYIDNCVLVEKNLAYAQAFHHVIPYEAAQTILHQCGKSLDYDRLAQETEVVGYPILPLVTQLAQECGEEAGKYVHWGATTQDIQDTATMMQMRDALICVEARLKAIIKTLSSLAEKYRDTPMAGRTHLQHALPVTFGYKCAVYLSSFQRHLERLGQLRPRCLLVQFGGAAGTLASLGPDTETSLKVRKKLAQQHGLEDPPLTWHTSRDGVAEIINFLALVGGTLGKVATDLIIMSSNEFGEVSEPFVSHRGASSTMPQKRNPISNEVILAASKMLRANAGLCLDAMLTDFERATGPWHLEWAAIPESFVLAVGALSQAEFALSGLIVNVDAMKRNLDSTRGLIVAEAVMMEAAKTMGRQRAHEMVYEACRETIESSDPERTLLETLSKKKDVIDTVPREKLEELCKPKNYLGAAGAMVDAVLALNDHYLCGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM08</accession>
    <name>N1PM08_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_111860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM08"/>
    <dbReference type="eggNOG" id="ENOG502SKHH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069642_0_0_1"/>
    <dbReference type="OMA" id="MEFQPNG"/>
    <dbReference type="OrthoDB" id="5296889at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="223" mass="25145" checksum="B51D6AA17150782A" modified="2013-06-26" version="1" fragment="single">APDLLLQAFNQAIRPYSDKIENLEGEIADLKAYIDALERQRGEVHAWIDKRGLRPDVPASIAQVMDQSSHQASPTHAAATLNAQLDRKITIVNFDLHRLQDDLNDSLPTPSFSACMLKFLPDIGRLSSLPSGPRYAFDLLLKLGGNLNSHGGLENGDEEDLRERRAFYGRLDDAMVDVVKGRFREEGDSWGVQREIKRIEKTGAYLRNWGVEPYFPNTLDVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM37</accession>
    <name>N1PM37_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase family 62 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_72037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM37"/>
    <dbReference type="STRING" id="675120.N1PM37"/>
    <dbReference type="eggNOG" id="ENOG502QVDT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017872_4_2_1"/>
    <dbReference type="OMA" id="WVESDKG"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF4">
        <property type="entry name" value="N-GLYCOSYL-TRANSFERASE (AFU_ORTHOLOGUE AFUA_4G06870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME44416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="405" mass="46187" checksum="9DED96FD8F1FE499" modified="2013-06-26" version="1">MLLPKGSNITWKSARARLPPSRAIWNFLTRTRFLLFVAVAGIIILIWNGVRGTAGDWQRFYCFGPAKSPMQMTPNEQAQWAGHLQTPVIFNHHAPIEINSSSIQRIDLNPITSTPQALQKQERVLILTPLRNAAPYIEQHFDLLYQLTYPHHLIDLAFLVGDSTDDTLAVLATELERIQSRTDKIPFNSAMIVEKDFGVTVGQDVEDRHGFKAQGPRRKAMGKARNYLLATALKPDHSWVYWRDVDIKDSPSRIIEDFVAHDRDVLVPNIWFHRYKDGHDIEGRFDYNSWQESDTGRKLANSLDKDVVLAEGYKEYHTDRKYMARMGDWRDNKDVEIPLDGIGGVNIVVKADVHRAGINFPCYAFENQAETEGFAKMARRAGYGVFGLPNYVVWHIDTEEKPGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PME4</accession>
    <name>N1PME4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_72146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PME4"/>
    <dbReference type="eggNOG" id="ENOG502QSXK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011027_0_1_1"/>
    <dbReference type="OMA" id="HQFANSY"/>
    <dbReference type="OrthoDB" id="1612078at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056948">
        <property type="entry name" value="PNGaseA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25156">
        <property type="entry name" value="PNGase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal" evidence="3">
        <location>
            <begin position="229"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME44591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="818" mass="89318" checksum="0AA1E1313BF763F0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PME9</accession>
    <name>N1PME9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_36441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PME9"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1026819_0_0_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29787" checksum="A73D7657E6C91F4A" modified="2013-06-26" version="1">MLDLPRITDFEILKGLKKASFRCDGGPDDSDLLIKYLQHRGGYYINVDASKMITDGKINKVKHGQEVAEITAHGLDFAAGTSLQADEIISATGYSNTRSQARVTFGDEVADRVRVVWGVDRKGLALQIEGVETDIGAHEAGEHNVKEWILEPSDDELLRLCYHAREIVLSPWQDRVHRAQVALCFVPLVLCSIAYLLHALRDTFHHLCHLRWSRAVGAVGAVSVAGETIVILLEADVARMLIASAATSFGLIVFSSAKVQNDLRVRSDDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN29</accession>
    <name>N1PN29_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_80398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN29"/>
    <dbReference type="HOGENOM" id="CLU_2320339_0_0_1"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="99" mass="11415" checksum="78D7C87F306DFE5F" modified="2013-06-26" version="1">MGRDVWHRERVSHWLQTPWPFCGDDSRPKKESRSSTHYRNIATRSTQTTSIGDLTTVGETRKILQDADYSFRKGANRKGSDAPLHRLQRRSISCPTTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNN9</accession>
    <name>N1PNN9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_152462</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNN9"/>
    <dbReference type="STRING" id="675120.N1PNN9"/>
    <dbReference type="eggNOG" id="KOG2975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027018_0_0_1"/>
    <dbReference type="OMA" id="EYFVHFH"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000019">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="30"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="201"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME44538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="344" mass="37747" checksum="352CFC9711CC41E9" modified="2013-06-26" version="1">MGDNSFLHLARPLAPAAVSSQAPNTAPITVNIQPQALFSILDHASRRPAEQERVIGTLLGSRSEDGTEVEIRNCYAVPHTETAEQVEVDMDYQKRMLELHLKAAPKEVLIGWYATSSELNTFSALIQNFYSQQGEGTFPHPAVHLTVSTIAGQDVKADTYISAPIGVTPERAADSCLFIPVPHEIKYGEAEKSGLELIAGARDREDRSQLLQTDLETLERAIEQVLEMLERVSNYVSNVLDEEAEPSSALGQFLMNTLSLAPKVEAEDIEKDFNNHIQDVLLVSYLANTIRTQIDLSNRLVTAALTMGPGDGNNESKGGDRKEGGNQRNNNRQGGDRGGRRNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNQ0</accession>
    <name>N1PNQ0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_72117</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNQ0"/>
    <dbReference type="STRING" id="675120.N1PNQ0"/>
    <dbReference type="eggNOG" id="ENOG502RZQQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081350_0_0_1"/>
    <dbReference type="OMA" id="FYEIRAQ"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME44548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="286" mass="32707" checksum="53E4804319B993B7" modified="2013-06-26" version="1">MGRYNFAAQNVHKHASQLLQTKRVSTPPPWYQAIATTPPSTRLTRQPLQRRQQPGAKPPRKRSRLFQPLNLKYREDGLRWEYFNDHPWELARPRVILENDGRDLEKWDWSLPLDYSLNRPSPGMEDDFGRKMDKVWDENMSTQSARPINGEAVIQRQQYLLQQGLRTAQAYDQARKELYRHRHAKEVEVRVAREEALSTGAYFGPGPLEIGMELEDKAYEHWKVWAAKEIQSLKQLAGSAYTGVDENAGLEVQEPEEEGLQVSEVANEVPGSKGGQTARGGAAVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNY1</accession>
    <name>N1PNY1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNY1"/>
    <dbReference type="STRING" id="675120.N1PNY1"/>
    <dbReference type="eggNOG" id="ENOG502QRU5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031559_3_2_1"/>
    <dbReference type="OMA" id="AWHNDAP"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="368" mass="40584" checksum="42394FACB57498FB" modified="2013-06-26" version="1">MRRITKKYLALANSATFASLLLVILYLNLSPSPSNRAFDWATVRYHTTANTLPEARGKCPGLAGSSKPALVVAKVIADGDSAWLDALSGKYHVCSYLADAPRDETSSTGQTPANRGNEAMAYLTWMIDNYDDIPAAGSVFVHGSRWAWHNDAPDYDNAALLISLNTTTALEPYGYHNLRCDWSASTCSPKEAPPQGSLETIFKAKMQPWDARAVSDAALPGALQTLFHDDATGSTTALGRSEAIRSQCCAQFIVSQTRLWQHSRAEYVALRQWLLDSGEKAAPADAKVAGRILSYIWHILFMQDADSTINLDRLNAQACPTAQECYCRLYGRCNLRNCDRPGRCQGQYVIPPDYRLPKDWESSHQAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPE1</accession>
    <name>N1PPE1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_129937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPE1"/>
    <dbReference type="STRING" id="675120.N1PPE1"/>
    <dbReference type="eggNOG" id="ENOG502SI30">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_6_4_1"/>
    <dbReference type="OMA" id="NVEGFHH"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF13">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109981" description="Tat pathway signal sequence" evidence="2">
        <location>
            <begin position="23"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27255" checksum="8D2E3C056D2FB4B3" modified="2013-06-26" version="1">MCCAVGLAIGVTLGAGAAAVYGRRNMTKTCLEHFSSASPVTRDIEVNYRVQQFEGHFMEENIYRQKGRPEVDEAWEALGINYRAVKVPSEVGLEVGLASDQVQINQKYGGGFPANVEGLHHLHCLNLLRKGLYYNFNYYKDLGEGAFQNEDHIVQKHISHCVDIIRQQLMCTIDIGVLGQVWYMPGGDDPFPKAFVDFNTKHVCRNYDDIRKWAEERQLPIDVPDDYLEPPKPGAKIRAGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPR3</accession>
    <name>N1PPR3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_43374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPR3"/>
    <dbReference type="HOGENOM" id="CLU_2775904_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="69" mass="7696" checksum="C26D2355B89D395E" modified="2013-06-26" version="1">MHVMSTTDRIYWVRLRSLLGLHSRAAENIPEQNAVKMSPAKRSRDTERARPTIAMAATATATIVTGCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPR6</accession>
    <name>N1PPR6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_52701</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="4"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPR6"/>
    <dbReference type="STRING" id="675120.N1PPR6"/>
    <dbReference type="eggNOG" id="KOG1322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_0_1"/>
    <dbReference type="OMA" id="GPNCWIC"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05824">
        <property type="entry name" value="LbH_M1P_guanylylT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000017">
        <property type="entry name" value="Mannose-1-phosphate guanyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="15">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="16">
        <location>
            <begin position="256"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME45421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="364" mass="39810" checksum="020507479DD3D538" modified="2013-06-26" version="1">MKALILVGGFGTRLRPLTLTLPKPLVEFGNRPMILHQIEALAAVGVKDIVLAVNYRPEMMTAALKKYEEQYGVNIEYSVETEPLGTAGPLKLAAKTLGKDDAPFFVLNSDVICDFPFKELAQFHKSHGQEGTIVVTKVEEPSKYGVVVHRPDHASRIDRFVEKPIEFVGNRINAGLYILNPSVLDRIELRPTSIEQETFPAMVKDGQLHSFDLDGFWMDVGQPKDFLSGTCLYLSSLTKKGSKLLSPTSEPYVNGGNVMIDSSAKIGQNCKIGPNVTIGPNVVVGDGVRLQRCVLLAGSKIKEHAWIKSTIVGWNSTVGRWARLENVSVLGDDVTIGDEIYCNGASVLPHKSIKANVETPAIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPX7</accession>
    <name>N1PPX7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_79145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPX7"/>
    <dbReference type="STRING" id="675120.N1PPX7"/>
    <dbReference type="eggNOG" id="ENOG502SVM5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068958_0_0_1"/>
    <dbReference type="OMA" id="HYFLEAY"/>
    <dbReference type="OrthoDB" id="5397846at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="83"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="347" mass="39256" checksum="366CE4D7B4134C58" modified="2013-06-26" version="1">MAASMTGKRKRNQVSYAIDEYFDNIEMDAAIPVAADSDDVQSDADNDGDDTTFGARKSRGKGRPKKKCRLTKAKKPKKEKPFRFLDLPAELRDEIYELALTDVDGLALVLRTKSYRRVVARGVIEVEGGSGSSSYYYGKKRRQSRWARYYDRNNDNDTDKISAPVRSLVPNLLATCQQIRAEGGSYLYKQEIILEDMTALQTFVAQIGQYNRDMLTDITVKGWGTGRGVHKGNNYSAFCLLASCTGLKELFLDCALGWYRNPKQLATQIFRDGHYFLEAYAAANGGIDAAVNLIQLDEEWHFDSSKRSSRYGHYNYGREDNGGNRSKEAEQSLKEEFQNELRALMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQB6</accession>
    <name>N1PQB6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_52492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQB6"/>
    <dbReference type="eggNOG" id="ENOG502RH8V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_446859_0_0_1"/>
    <dbReference type="OMA" id="DHAPRQA"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18967">
        <property type="entry name" value="chromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="491"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="610"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME45128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="670" mass="74809" checksum="EE6D42D29C67A1E2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR33</accession>
    <name>N1PR33_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_33506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR33"/>
    <dbReference type="eggNOG" id="ENOG502RA77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1360369_0_0_1"/>
    <dbReference type="OMA" id="NITHIGH"/>
    <dbReference type="OrthoDB" id="3647480at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="201" mass="23058" checksum="956B90423A49FC0B" modified="2013-06-26" version="1">METTTTASLGNLPVELFLHVASYLSKSSLLSLRLANNDFRDLLHHIWLRVARQSTMSLCERVAIDRYTFEEDDVKRGRRKCLICGTHGLTTQFKSAAPICNAHQGRFTRWHVPENRSGWTLAQYERDAAREAVWVNVQRPFCVHEQKIVGWDVELCRCDCSDCGHFMVDCRVRVQLEDNKLSFCGAPRAMETLEGKHCLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR99</accession>
    <name>N1PR99_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Maf-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_168188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR99"/>
    <dbReference type="STRING" id="675120.N1PR99"/>
    <dbReference type="eggNOG" id="KOG1509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_0_2_1"/>
    <dbReference type="OMA" id="RDQRMHK"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29295" checksum="25726B074D38B8BB" modified="2013-06-26" version="1">MADQKVPLEAPPAYTDHPKPASNASTPVRPGLPVPPRPLDLPALSMIRGRRVILASASPRRRQLLAQIGLTQLEIIPSTLPEDKDKSLAPFEYVLQTAEQKARNIYQQEIDSSKGEPALVLAADTVVSTHMGQILEKPRNEKEHFATLRMLRDQNNGWHKVYTAVVCMSPLESLMDPGYAMETHVEETRVKFDQDVTDDLIMSYVKTREGADKAGGYGIQGLGSILVEKIDGTFDNVVGLPLRATLQLIEKVVVEPGVPEEVDEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRU1</accession>
    <name>N1PRU1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_70238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRU1"/>
    <dbReference type="STRING" id="675120.N1PRU1"/>
    <dbReference type="eggNOG" id="KOG3486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167122_2_0_1"/>
    <dbReference type="OMA" id="GESDACM"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME46176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="86" mass="9583" checksum="FBCB795135BA2669" modified="2013-06-26" version="1">MENERGELVDLYVPRKCSATNRIIKAKDHASVQISVGKVDENGRYTGENQVYALCGFVRAMGESDDCVNRLAQRDGFVKSVWSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSJ2</accession>
    <name>N1PSJ2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_148636</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSJ2"/>
    <dbReference type="STRING" id="675120.N1PSJ2"/>
    <dbReference type="eggNOG" id="KOG0240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_3_0_1"/>
    <dbReference type="OMA" id="FPMGTKQ"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="6"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="376"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="857"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="772"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="904"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME46421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="926" mass="102884" checksum="C8CF4D0DF99EFAF6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSM2</accession>
    <name>N1PSM2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_70447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSM2"/>
    <dbReference type="STRING" id="675120.N1PSM2"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027981_0_0_1"/>
    <dbReference type="OMA" id="PTCPICM"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF416">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE GODZILLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="343"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME46451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="552" mass="60456" checksum="4457740FE8176543" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT05</accession>
    <name>N1PT05_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_71270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT05"/>
    <dbReference type="STRING" id="675120.N1PT05"/>
    <dbReference type="eggNOG" id="ENOG502SMMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_0_0_1"/>
    <dbReference type="OMA" id="MRDTWNA"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="62"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="234"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="337" mass="36639" checksum="3697488454D74E71" modified="2013-06-26" version="1">MTTNGNLEHYRAVIGNAQNFWLYSSTTGFDLTHPPKPTSPPITPSVTIQTTTSPITIDPAKSALVIIDMQNFFLSSALGKVRGPGHDALDRLVEHAIPACRKAGVRIVWVNWGLTEQEVQDMPPAVKRAFGFEAVVKKGEWEDDEVVHESREAAFAVNKHGMPQREGGAIVTNGPAGKKRLYKGIGSDMGTVRDPETEGEIEVGRMLMRGQWNTGLCAPLDKVFAEGARLATGPDVWIHKNRMSGLWGARTELEEFLEEEGLRTLFFAGVNTDQCVNGTYQDAFSKGYDCVLLSDGCGTTSPGCAQQGVEFNAANTCGFLVSCKMLAEGVAKMEQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT20</accession>
    <name>N1PT20_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_34043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT20"/>
    <dbReference type="HOGENOM" id="CLU_625593_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="438" mass="49499" checksum="E77AA3DAB2AD0BF2" modified="2013-06-26" version="1">MCLHAIQQTMTRNSTLRRYSASSTTKSRRSRRNVWMALLQMADCFAMTRKLASPFTSAQQNRQSLQEHHFERFSPITYPAVSKQHYPSACLSWSDLPSRQKRLKLQKVTICLIGLSNVKSSRPVQPPPILLLPHLLRVILRLLLLHHLPPHSPNSPAPYRLHNTLMFLISIPRSSGIVSVWHHDFAVSRWRKQMSRILDTIGNILQISVFFWCETWLVRFWLRLRFCFEHHTQYLELGLRKDVIGTEIAEGEHLILFFDFGADVMGLTSGIADEFCLSVVPERFVGWAIEVLAYDVALAGDFGHVPSVTREGYITVELDVVAACVLPNKAIFVSHGLAPGVLGVISPHAFLRQWLVVSSALCGILQKESDLDLIGIVEVSADQDGCIEEGVVQYTFEGIDHRNNIFCHENFHSLRGSHTTTRQLLPLVSEAIHNGNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT82</accession>
    <name>N1PT82_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_71342</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT82"/>
    <dbReference type="STRING" id="675120.N1PT82"/>
    <dbReference type="MEROPS" id="M41.004"/>
    <dbReference type="eggNOG" id="KOG0734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_9_3_1"/>
    <dbReference type="OMA" id="MSHFEWA"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="314"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="724"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME45609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="764" mass="81849" checksum="87D5E0C3DF359C71" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTF1</accession>
    <name>N1PTF1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_169550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTF1"/>
    <dbReference type="eggNOG" id="ENOG502S6CG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029871_3_2_1"/>
    <dbReference type="OMA" id="YITQASQ"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF1">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110139" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="75"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME46746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="438" mass="46978" checksum="A0FA9B9C3B40F429" modified="2013-06-26" version="1">MKLPTSSAFLGALPLAAAFPFQLMEKFQNDPEMQARASNLMLGKRQAGADAATGLFEAIPTFDAQKQLIDVGPGSDHEWQAPGPNDLRGVCPGLNAFANHGFLPRNGYATVEQFIDITTEVVGMGADLAGFLEVLGALIDSGDLMSWSIGGTPGPGIGGPLASGGNGLIGSHNKYENDVSPTRPDLYESGNNYITQASQFQDLINASPGGVVTLDSLAEYRSQRFDTQLANNPYFFNGPFPGLLVQPAAFTFIYRFMANHSAKDPIGTLTYDTIQSWFGIDGENGNYTAPFGYERIPANWYRRSFSAPYTIPYFLGDVVNFAALHPKFLDIGGNLDGKTNNFAGVDAANLTGGLFNSADLLKGNNLGCFAFQTAAQVKSDLTLGAVLTAVQNAVGGIVSQLGCPQLEKIDEAQLEQFPGYEKAPFLRRRSVRRNGEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTI3</accession>
    <name>N1PTI3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OsmC-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_171295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTI3"/>
    <dbReference type="STRING" id="675120.N1PTI3"/>
    <dbReference type="eggNOG" id="ENOG502SD2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100275_0_0_1"/>
    <dbReference type="OMA" id="KSKWINE"/>
    <dbReference type="OrthoDB" id="3906254at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052924">
        <property type="entry name" value="OsmC/Ohr_hydroprdx_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368:SF1">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19368" checksum="EE57939A50F1E9CE" modified="2013-06-26" version="1">MKRALRTFTQPVVYRTTRTIRPFSSTFARQDTIPFHVDGQGTGVAQAVGVKDTPHTIYTDAYPAFGGNNVHPSPLHFNLAALSSCTQVTGSIVAKDHGIRLKEWKVSVTGHLDPAVLVGGAEGNGNWNSITLDVEVAAEADAAKFDKWTSEVERRCPVTQLFKRSGAEWSSKWVNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTP5</accession>
    <name>N1PTP5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_71433</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTP5"/>
    <dbReference type="STRING" id="675120.N1PTP5"/>
    <dbReference type="eggNOG" id="ENOG502RKGU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_2_1_1"/>
    <dbReference type="OMA" id="CGSKWYT"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109590" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="428"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME45735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="492" mass="53505" checksum="4AE7778DFCDE686E" modified="2013-06-26" version="1">MKFSFGSILAATAAGLQLVNAIDLDPNNVTSIKAAARTLAFALQSYYVNNQTTTPPGMVGTWPGPTWYWWKGGAIWGGMVDYWAYTNDSAWNTVTQQGILAQVGPYYNFEPPAYNGNLGNDDQAFWALAAMSAAEYDFPVAQGQNVTWIDLAKAVFDRQVARWDTATCGGGLRWQVFEANQGWNYKNSISNGGLFQIAARLARYTGNQTYIDWSEKTWEWMSDIGLVSPSYQVFDGSDVLKNCSELDHTQWTYNPAVMIYGTAALANLTDDPIWKNRTEGLLTSIENTYFSVFPNATDIMVESACEPTNNCDDDQLSFKAYLSRWLAKSAVVYPAILPNVQKYLTTTALGVAKACTGNATGDACGQKWYTGGFDGRTGYDQQLTALETVQALLLLNGAAPKMFPDTSDNVTIQVRPVTSTFPLEAPTITAAKPPKASSNGASSSSSLLTRSASSGTRSTDWPNRSPWATLNSWAFGIGLISVIAISVMGMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUD3</accession>
    <name>N1PUD3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_70095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUD3"/>
    <dbReference type="eggNOG" id="KOG1196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_29_1_1"/>
    <dbReference type="OMA" id="YPIKNIH"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="20"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="351" mass="38898" checksum="EA5EBBC16E6DFB66" modified="2013-06-26" version="1">MVQNKALIFAEVPTGWPEAGKHLKIENRDFDTEQQPPNGGITAKVHYVSFDPYQRGRMRAPEVKSYAPPFELGKPVTNAAILTVLKSDNNKFKSGQVLFAPRTWTEEYSAIDKDLADSFMVLENPYKLDPKLFIGALGMPGLTAYSSFYEIGQPKKGETIFISAASGAVGQIVGQLAKHEGLTVIGSVGDDKKLDFITKDLQFDAGFNYKKEKPSDALQRLAPDGIDIYYENVGGEHLEAAINHIHPFGRIVACGMVSQYNLKPEEQYPIKNLMQVVAKRIKMQGFIMTDENMGPKYAEEHQKHVQKWIHEGKFKAEMSVTEGIDNAADGLIGMLAGKNFGKAVLQVSKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUG8</accession>
    <name>N1PUG8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_126111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUG8"/>
    <dbReference type="STRING" id="675120.N1PUG8"/>
    <dbReference type="eggNOG" id="ENOG502QPMY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_6_0_1"/>
    <dbReference type="OMA" id="TPYPENM"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME46010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="329" mass="36131" checksum="D762C50FDD2128C4" modified="2013-06-26" version="1">MTTIKVGVVGASGETGSSIVNGLLEAGNFEIIALTRPTSISKPFNLALASRGIIIREQDLSATSDPASLIPAISDLTIIISSIAPLDQAAQIPLATAAKAAGIKRFIPCAYVPVMPAGGTHILRDLKEQVYNHIKTLRLPFTIVDVGWWYQLSIPKLPSGRTDEFLLMGKSEIAGDGNVSSALTDLRDIGKYVARLAMDERAENRYVLVYNEMWTQNEVYKLVEKESGEQIERNYVSKEELEERVASVPEGSLDVTTLSVKAPAQYMLSWGVKGDNTPEYAKYLGYVTSKELYPEMEFNGFEAFVKEVLKGEAPTIYEELKKQFAAAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUS9</accession>
    <name>N1PUS9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DOTSEDRAFT_70643</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUS9"/>
    <dbReference type="STRING" id="675120.N1PUS9"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_7_2_1"/>
    <dbReference type="OMA" id="AHNWLFT"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109357" description="alpha-amylase" evidence="17">
        <location>
            <begin position="21"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="18">
        <location>
            <begin position="33"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="50"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="262"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EME46703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="513" mass="55613" checksum="D13AEAA9483C5D8A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVB7</accession>
    <name>N1PVB7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_42840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVB7"/>
    <dbReference type="STRING" id="675120.N1PVB7"/>
    <dbReference type="eggNOG" id="ENOG502SHH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048612_1_0_1"/>
    <dbReference type="OMA" id="QPPIQED"/>
    <dbReference type="OrthoDB" id="4106209at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="287" mass="32510" checksum="37CDE00D0D22E956" modified="2013-06-26" version="1">MRRQTPIAHLLYAHLFPHPTPNDPPSFSAHLARNLVPEVRIEVATFYGDLNSAEARYPGLNYCHPPHRMRLGRFRHHQRLFEAFDSLGLTYNEVQDFCCWEGTKWARERYEKDECVIVVDTTGNEIGPYVDRRDRPSEGYVRHSITKKTEISVVVEDADASSGRQPPIQEDDEEMDDAESGGEAETADVNMEDEQEPHAEAAARQHHMAQLQQRRDHAITQRINQRILAAWERGHPLPPELEAYLKEQSERGDADLSGLLSGRRSSQRFAPPESAAPVASQASRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVD6</accession>
    <name>N1PVD6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_125279</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVD6"/>
    <dbReference type="STRING" id="675120.N1PVD6"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022829_2_1_1"/>
    <dbReference type="OMA" id="SMKQCIE"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="236"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME46374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="583" mass="65867" checksum="ACB9ABA7F8658FDB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVZ9</accession>
    <name>N1PVZ9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_22586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVZ9"/>
    <dbReference type="STRING" id="675120.N1PVZ9"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2372774_0_0_1"/>
    <dbReference type="OMA" id="ACTMVAP"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="95" mass="10322" checksum="EF84CB2EDA44DA4C" modified="2013-06-26" version="1">MLIAMSAFVAPTACTMVAPALDTTADVYRIESQIEKFLKMSILVLAFATGPFVFSEVFARVCVVRGANLIFLMVNAACGFAKAKQQMTVFRSYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXF6</accession>
    <name>N1PXF6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_20899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXF6"/>
    <dbReference type="STRING" id="675120.N1PXF6"/>
    <dbReference type="eggNOG" id="ENOG502SK2A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058481_1_0_1"/>
    <dbReference type="OMA" id="THWILHE"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="276" mass="31911" checksum="052FFBF12A0BFE76" modified="2013-06-26" version="1">MAAVEKERPLNELLSREMVDIYVGPSNTHWILHKKLLCYRSQFFRNIFNPKRGSKKASENSVYGLPDDEDEPFRLFVGWLYSERVPPPKEEKDLSPLLDMYLMAEKWEIRRLIIEVLDAVRLYYYESDTWPSLRRVQYIYANTEQESPMRQLLVQCVARMLVTGQGVPQHWENALRKNGQLAVDIILTVQKWHFDPESVPDARVGNVKEVVEEAEGKGMKMEDDQKQGREEEEEEDEDNVLDWGEGKTYSQDGSRSQSQVGGGGESDADKTLVNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY82</accession>
    <name>N1PY82_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_119444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 6"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY82"/>
    <dbReference type="STRING" id="675120.N1PY82"/>
    <dbReference type="eggNOG" id="KOG0549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_8_1_1"/>
    <dbReference type="OMA" id="PKTCDIQ"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110281" description="peptidylprolyl isomerase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="43"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME48486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="141" mass="15267" checksum="4385C113C6854C2B" modified="2013-06-26" version="1">MKFTAITTAVALLCAGALALDKPLNIEKTHSEDCADSERTKIGDKISMHYRGTLEKDGSEFDASYNRNQPLDFAVGKGQVIKGWDEGTQGMCIGDKRTLTIQPEYGYGDRGVGPIPGGAVLIFEIELMGINGKTKEAQKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYZ9</accession>
    <name>N1PYZ9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_67703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYZ9"/>
    <dbReference type="STRING" id="675120.N1PYZ9"/>
    <dbReference type="eggNOG" id="ENOG502SANW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015530_0_0_1"/>
    <dbReference type="OMA" id="HWNLLIC"/>
    <dbReference type="OrthoDB" id="5342758at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55194" checksum="6CD7038C648AEF29" modified="2013-06-26" version="1">MNMLSSDSWYAQASSSKVRLSNSSHELPRRRSPSPSASIIPPPIVQSVAQLPRAASAQSTRSERPSLFEDRQQELEADIQFLLDAQAEGLIRGLEGGAPDDRSSTGSTTPTAQSVRSAVARRTRKPARRQPGLRSARKGIYHAISALSALKNDEIQDVDAQLQEHQDTLAQIDDWEDKRNGLKEASESTNCGGDTVRMQRLQQEADNLQAAINTIELQLMDMKSRHRSLLKQAGAVENSIQAKMASYSSSLHLLEEEVQAFLNVKPDSREPRLNPADGGQSMWQLPTKRRNLDMAKQYWTEQRKSTLDARRQHEQEKKALVEGARLWKETVTEVTDLERQLRAEMSSFRPVSPESPSAWDDAPLSEPTDHSEQLKETLSKMQSVVLSIEAKLQRAEDSRWTLLMAAIGAELDALKRGKEILTSVLGVTEPDLIEDNGHDAQKNSPGQELRALDKSFETAQIAGQESPQHKEEDDDNDHDEPDPELLFSRQDMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZ21</accession>
    <name>N1PZ21_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_147557</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZ21"/>
    <dbReference type="STRING" id="675120.N1PZ21"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017661_1_1_1"/>
    <dbReference type="OMA" id="HSGAMLC"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="547"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="607"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="648"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME48248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="797" mass="87148" checksum="45C9BB80A5188594" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZK1</accession>
    <name>N1PZK1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZK1"/>
    <dbReference type="STRING" id="675120.N1PZK1"/>
    <dbReference type="eggNOG" id="ENOG502SF71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_291720_0_0_1"/>
    <dbReference type="OMA" id="YWGDLPS"/>
    <dbReference type="OrthoDB" id="3650432at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="866" mass="88515" checksum="FF5EF5B3A1800B07" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZV6</accession>
    <name>N1PZV6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_99233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZV6"/>
    <dbReference type="STRING" id="675120.N1PZV6"/>
    <dbReference type="eggNOG" id="ENOG502RHPC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191095_0_0_1"/>
    <dbReference type="OMA" id="WWKNVGM"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="87" mass="9356" checksum="4E1AF3A7B5F24CD9" modified="2013-06-26" version="1" fragment="single">SPASQGLTRTGRQIEAAGADRIAGLTMATRAMKLKSPKKASMWDLQNREVSARRQVGDAADSINKPPSSAVGSEKPWWKNVGMEEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0P3</accession>
    <name>N1Q0P3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0P3"/>
    <dbReference type="HOGENOM" id="CLU_1510568_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="178" mass="19547" checksum="E988DEF2872DBE35" modified="2013-06-26" version="1">MRSGKRSTKTLEPAKTKSRARSIGKRLDSPNVHAIIEECAREDRSPADDVDAVIRQVKAILVMAVEGQVEIVTRKAAVTRPFRFFDLPAELWSRIGKLVIQNTDTCEEDNLNLPNTIPGVSRNTSAVGARTFSSLPSRAPAESFVPSFCLCSTRPRSRCLRSHARRNAPSGWAGGCMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1K2</accession>
    <name>N1Q1K2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_67997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1K2"/>
    <dbReference type="STRING" id="675120.N1Q1K2"/>
    <dbReference type="eggNOG" id="KOG1868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005922_0_0_1"/>
    <dbReference type="OMA" id="PFVHTYE"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF23">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="383"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="697"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME49118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1079" mass="120611" checksum="0F469B3BCFB87947" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1Q1</accession>
    <name>N1Q1Q1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_113257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1Q1"/>
    <dbReference type="STRING" id="675120.N1Q1Q1"/>
    <dbReference type="eggNOG" id="ENOG502S7E3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103432_0_0_1"/>
    <dbReference type="OMA" id="AFYGYAM"/>
    <dbReference type="OrthoDB" id="2550114at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="147" mass="15919" checksum="28C0DC7376615131" modified="2013-06-26" version="1" fragment="single">PRLLVSLLVSEPRTATDLESYLSRTLGFALLTLAVICILLTGFLPVSSQVAAAQEEDSDGSIKDPYAYPTLIATTTYHATSAFYLYTKVAYGFTFGFGVGLVASAGLFCVGVWVLLFGSEKGRISRRTGADKRTSNFPFENKESARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q243</accession>
    <name>N1Q243_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_67554</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q243"/>
    <dbReference type="STRING" id="675120.N1Q243"/>
    <dbReference type="eggNOG" id="KOG0751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014931_2_0_1"/>
    <dbReference type="OMA" id="AFQNVMR"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000552">
        <property type="entry name" value="Probable mitochondrial carrier protein ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="356"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="455"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="557"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME48544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="724" mass="80025" checksum="204F6C16F8441EEC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2D5</accession>
    <name>N1Q2D5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mox7</name>
        <name evidence="7" type="ORF">DOTSEDRAFT_58106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2D5"/>
    <dbReference type="STRING" id="675120.N1Q2D5"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_1_1"/>
    <dbReference type="OMA" id="ETFKHSG"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000270">
        <property type="entry name" value="FAD/NAD(P)-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF315">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE MDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="6">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME48805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="490" mass="54871" checksum="33A06833F0619817" modified="2013-06-26" version="1">MAVDGVDIKPLGSYPASGIDVLVVGTGLAGLTAAVECIRKGHNVRVLERYATINTQGDMYFMGLSATRFFKHWPEMKAEYDSIGLHNAWIETFKHSGEQMIPPLSVAERLRDAGLDPNTPPGTFQMRPLIYQMFVKQVEKLGVDIEFNRRVVDYFEDEATGKGGCVTEDGKRYEADVVIAADGVGSKSQKLVGGQVRARSSGRAMWRAAFPIGHLDKDPEVKDFFKMVGPEGNNPVVRTFLGPGTYALTLTRAETQIWIMNHNATNSSAENWNNKIDSQEVLDQMDEGVGSQPWAPIFKKLVKCTPPNTIVNFELLWRDPQPSWTSPNARVIQIGDAAHSYLPASSNGATQAIEDAVSLASCLQLGGKDHIAEAVRSHIRFRFIRTSCAQKLGFSNAELLQETDWDKVKLDPRRAQPKLPKWVWCHDPEKYTYEHYRRNVENMKAGIKFDDSDIPPNFPPGYKYEPWTIDWIMDCMYKGVAVDLGPGQWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2E8</accession>
    <name>N1Q2E8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Formin binding protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_68630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2E8"/>
    <dbReference type="STRING" id="675120.N1Q2E8"/>
    <dbReference type="eggNOG" id="KOG0152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005825_1_0_1"/>
    <dbReference type="OMA" id="RDEIFQD"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000013">
        <property type="entry name" value="pre-mRNA-processing protein 40A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="164"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="231"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="377"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="572"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="639"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME49887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="88752" checksum="655A5B803246B957" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2F9</accession>
    <name>N1Q2F9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_67618</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2F9"/>
    <dbReference type="STRING" id="675120.N1Q2F9"/>
    <dbReference type="eggNOG" id="KOG1956">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_1_1_1"/>
    <dbReference type="OMA" id="SKYKGWT"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000005">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="9">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="10">
        <location>
            <begin position="173"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME48634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="675" mass="76308" checksum="0E0C8436453DC140" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2M1</accession>
    <name>N1Q2M1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2M1"/>
    <dbReference type="STRING" id="675120.N1Q2M1"/>
    <dbReference type="eggNOG" id="ENOG502S7U4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587958_0_0_1"/>
    <dbReference type="OMA" id="THERGHW"/>
    <dbReference type="OrthoDB" id="5395975at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="465" mass="50936" checksum="60BD68695B4BD84A" modified="2013-06-26" version="1">MRAGKQPAFTPTAPDITVLAEDSQLAYTALESQLQNSARVFFHKTPTEITSEEAAIEATTHAIDYAFAKSCKPTPQGKTTALLVVTPGRSATRPVAQSVALRSARSHSWPRNARSSQSSYLISPALVRSSKRRRLDEYVSKVDQQPQATAQTAAQNVLAPVSPVVRGTSSEGGIHAQRTASANEDSSELPTSYSISDEVLESLKRRSRTSQRSASVPGPQSLSPRQSVRRHAASQHEIFYASEPAKTPKQPKDTKTPGAAHGSKPVTKTKFKPPTVDGQQLVDLQSLSLVIQPPNVVAGRHFGTHITPTLQRLVDGEVAKCFKPTFEPRAIDDLERGHWRMNIPNWPVAQLAAFWRTLERLIGGGNAGWGVWCTREPDSRLQDKAESTEASDGTSNRWINSGSDPRYGTVRVYCWGEVVKHIYLLLYVSSNSKVRKLGLQWLDSQGKVVIQMPAKEPSRSSFAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2X3</accession>
    <name>N1Q2X3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_68838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2X3"/>
    <dbReference type="STRING" id="675120.N1Q2X3"/>
    <dbReference type="eggNOG" id="KOG1087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036827_0_0_1"/>
    <dbReference type="OMA" id="YGSVHRQ"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="3">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME50101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="413" mass="45604" checksum="1A1D320E81B41FAC" modified="2013-06-26" version="1">MFSGSSKKPYTAITALIDRYTSEQYDEDDISGVIDLVDVIRIQESGPTEAARALRKKLKYGNAHRQIRSLVILDGLIQNAGGKFQRTFADEPLLERLRLMARDDMVDATVRQKCRVLFAQWANAYKSTAGLEQIANLYKEFPKTQRPEAARQKVLRDTAADPDQESPFAEPSSRSRSNSKAKQLSHSATTPLRPVTLTPTSSGFSHKLFKEKKDKSGKSFSLSREKDNMTNSIAQASIASTNLMNGLQLINRESERVSNNVEVLNRVEACRLLRRKILHYIQHVESDEWIGSLVNANDELVKALTAYEIMDRSISDDSDSDAWDNVGGIEASGGHARSSIAEQQLAGLKLHNAPPVKPPRPAAPAAIPMPSRSPMPAASAKVDADEDDDDPFGDSHAAGTPFDERAGMTWREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2Y6</accession>
    <name>N1Q2Y6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DOTSEDRAFT_68786</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2Y6"/>
    <dbReference type="STRING" id="675120.N1Q2Y6"/>
    <dbReference type="eggNOG" id="KOG1179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_46_3_1"/>
    <dbReference type="OMA" id="VWRQFLD"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="84"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="21">
        <location>
            <begin position="521"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EME50047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="649" mass="72821" checksum="EEBC4DF590B94C8E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3N0</accession>
    <name>N1Q3N0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase lambda</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DOTSEDRAFT_76625</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3N0"/>
    <dbReference type="STRING" id="675120.N1Q3N0"/>
    <dbReference type="eggNOG" id="KOG2534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3507">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008698_3_0_1"/>
    <dbReference type="OMA" id="KWHGASA"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="133"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="269"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="728"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="744"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="18">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EME49265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="827" mass="92509" checksum="88416E2EECB7FBC9" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3Y4</accession>
    <name>N1Q3Y4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_121804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3Y4"/>
    <dbReference type="eggNOG" id="ENOG502T15U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152670_0_0_1"/>
    <dbReference type="OrthoDB" id="3650555at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="107" mass="10835" checksum="D515042488C7C68E" modified="2013-06-26" version="1">MAASAVAKQPPKEVSKAENSAVIEEKEQSAKASASAGLNMNVFGAIAGAFSSKNTKKTEEDGSALEEEEKSASVRGAGAGSIDAQGAAHAEQSGRQMRAAIQEKNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4J2</accession>
    <name>N1Q4J2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_68485</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4J2"/>
    <dbReference type="eggNOG" id="KOG2662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025144_2_1_1"/>
    <dbReference type="OMA" id="NERIKMA"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="461"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME49720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="538" mass="60635" checksum="6324623406B286FF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q553</accession>
    <name>N1Q553_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_85379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q553"/>
    <dbReference type="STRING" id="675120.N1Q553"/>
    <dbReference type="eggNOG" id="ENOG502QQSQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031135_0_0_1"/>
    <dbReference type="OMA" id="CLAGCMW"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF1">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="244" mass="27681" checksum="F94EABD64822CD7E" modified="2013-06-26" version="1">MLPPKLPWTTSTAIGLKAFWKWFLTPFGFLIILYGLDVVVWGGMLFLLLCNASPAMCWAPDGRGGKFHDCNDINSPRREWRKHGKKRKMYGLRKLAAHYRSWYRLPGSETLDAVLQPDDIIECDLRVPMPVSKRTNDPPTGERAPPTPIWKLDFFIWCQVWNIFFQCCLCGFMWGLNRYNRPSWATGLFVALACGVAGIGGLVSFLEGTKVKRIEGVSSSLAQTEAVQESIHLRQENSGNEVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5A4</accession>
    <name>N1Q5A4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_77351</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Peroxisome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1Q5A4"/>
    <dbReference type="eggNOG" id="KOG0736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_0_2_1"/>
    <dbReference type="OMA" id="KIMLCEP"/>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23120">
        <property type="entry name" value="PEX6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="1045"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="272"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1319"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1327"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1382"/>
            <end position="1393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME50315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1447" mass="155493" checksum="D39DAF46DB78D932" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2WHJ3</accession>
    <name>M2WHJ3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_29665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WHJ3"/>
    <dbReference type="HOGENOM" id="CLU_877242_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="317" mass="34088" checksum="9A5A614571827503" modified="2013-05-01" version="1">MPRRWSIEERHFLHLAKNEYYLSWPQLTRLFALAFPHASDNGVLLTADQLERQYESRHIENKRMWRGEIVRATYTPEQEGDRDEARHLIRTAAATDGMVLQHVPQVGNSQGGSDVAIAGAAGQASYPSIASSSASSSSSRAPPYTIPAWNASQSPSMLPPAASRLVPFIPSESDAGNGSFARSATGNRSTHGNYNANSASMGSPVTPSRVRTTPTGPLNASSSRIAQQRQENLRADREGAGSFYSTYDNPLYGNTSTSTPNVSPVRRNPLQDRAAANLATRHPDDTTDGTSRPAAMPTSRAVSREAGSPQQGAGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2WHR0</accession>
    <name>M2WHR0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_39669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WHR0"/>
    <dbReference type="HOGENOM" id="CLU_324655_0_0_1"/>
    <dbReference type="OrthoDB" id="10655631at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="889" mass="99490" checksum="3E89156BB8ED836B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2WHS7</accession>
    <name>M2WHS7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_29740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WHS7"/>
    <dbReference type="HOGENOM" id="CLU_936975_0_0_1"/>
    <dbReference type="OrthoDB" id="10621130at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="297" mass="33096" checksum="55A85DB7987EC3AF" modified="2013-05-01" version="1">MAEEIPAQRALSSRQRTDRPEDDAQKAFGPLQHAGEQQAKSQPHNELDLAASRASNPRLKIEQGGSRHGSSTLGLSHDLPVVAAYSTDGLNRNIGVDKWVAGQGDSSHVSNEPEDKSHRSVDLKSAGDRTHVGRPVQPLSDQCERRSPADRASIPGLLARSVASANNTTHSPAASIPAPYTPTQAYHLPQLLQVPPAKWTISDFQILHATYKRGQSPAEAAVHLHKFTLEDVQAMWFEKFTKKKERQRNRDQRHAHEIQGWDQPDPQRLGIKQEDEEPRQTFRQNIMGNLKKRTRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJT5</accession>
    <name>M2WJT5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_75075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJT5"/>
    <dbReference type="HOGENOM" id="CLU_1906677_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="133" mass="14465" checksum="92081462749751B4" modified="2013-05-01" version="1">MMSHDRDSFHEGKLSTTSTCVATNSRLSRSLTKRVKSSTVFVDSPAPQLDVSLLSSAIGDLGSSTRHEATSSPSHGPSDTMVRHLHVVSSIGHLLRTPLQPRSQAARDLLPTQSRRCLCSLGGHFRRSKLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2WKN0</accession>
    <name>M2WKN0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_138790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WKN0"/>
    <dbReference type="STRING" id="675120.M2WKN0"/>
    <dbReference type="eggNOG" id="ENOG502SA7H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_776370_0_0_1"/>
    <dbReference type="OMA" id="GRVMNAK"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004028071" description="FAS1 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="39"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="377" mass="41522" checksum="04C1FFE6471E8127" modified="2013-05-01" version="1">MIAGHSLALLCASALSFRNVLAHSQDDQTRSGVQSSGDLQPVLTTISQDPDLSMFYNLFYKTGFMGKPGPMFEEHFNDPRRLDKSKFTVFAPTNEALRKLPSTVIQQLQEPASFPLLEQILFTHVIQADFKPQDFGSNRQYHTAGQSTLSIDRGGCITSNAGLTRTAVAQHCQARVVSQRSGPLRASNGFVYKIDNLIDGLITYFGEDTAGAMPSVSYESGTVQDVLARDSQLSTLNQLFKDIAPFYLIQIGLYDADRQTGREKWIYLAPSNEAFEALPQSALEAMRAPATNPFTSFTLGFGKSPLPQTQRMPMQVTSTTGFNITIADGKVNNARIEKETCVDNACIWHIGRLIDPIYPGSYRPQAAAPGSYRQQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2WL36</accession>
    <name>M2WL36_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_28805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WL36"/>
    <dbReference type="eggNOG" id="ENOG502QZNM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2236512_0_0_1"/>
    <dbReference type="OrthoDB" id="3637629at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004028076" evidence="1">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="105" mass="11299" checksum="48229E4A26E41B6D" modified="2013-05-01" version="1">MYSSIIAIATLALASSVSAGWNGRGNGWRTDTGTSCCWQGLRHCQQDQGDWGCVQINGGGPNCVRQTRECDDACGGSGYAYQRTRSNDDTCICTYDDASQQADRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2WL70</accession>
    <name>M2WL70_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mox5.2</name>
        <name evidence="7" type="ORF">DOTSEDRAFT_48143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WL70"/>
    <dbReference type="STRING" id="675120.M2WL70"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="OMA" id="YKHMVGH"/>
    <dbReference type="OrthoDB" id="1878542at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME39718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="426" mass="46943" checksum="327C2B086CFE6816" modified="2013-05-01" version="1">MGGLATALALAKKGFKNIDVYETASSLGFVGAGIQLAPNMARILDRLGVWADIEKEAVDLKETSIRQGSTDNQLAHVDLKYIRSTYRYPHMVGHRSSLAASIYEGCKKEKAIRFHFKTAAGEVKSYGPDPTFMAVPREGEPFKVKCDVVLAADGIKSTVRDQMLRLKNIDAKIIDTGQAAYRIMLTREQMKDDPELLELIDGEMVTRWIGEKRHIIAYPVSSKQIYNLSTVQPDVNFAAGPSATYTTRGSKPQMTEVFSDFCPKVRRMLDLVPDGEVCEWKLRVHEPLPTWVHGQTALVGDACHPTLPHLAQGAAQAIEDGAVLSVVLSKLPSSSPEDITKALKVYEEVRRDRAYQLVELAAASGRALHLGDGKAKEERDQQFAALKEGKGPVPDKWADADVQKIIYGTDVMAVADEQFGEIYAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2WLK3</accession>
    <name>M2WLK3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WLK3"/>
    <dbReference type="STRING" id="675120.M2WLK3"/>
    <dbReference type="HOGENOM" id="CLU_2158302_0_0_1"/>
    <dbReference type="OrthoDB" id="4777915at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="111" mass="13301" checksum="DA4EAB80710B186A" modified="2013-05-01" version="1">MSRRHISPDTPTSFRHRGLHDGILRNVFLYYDKDSIDSVLLPTGFYDDMWCYAIGPDFEDDSEEYVGEDSGEIHPGYFKVRTQQFVNRFFEARKYHEESLSMERLWWQHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2XIL8</accession>
    <name>M2XIL8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_28471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XIL8"/>
    <dbReference type="HOGENOM" id="CLU_1660708_0_0_1"/>
    <dbReference type="OMA" id="TSIYPYP"/>
    <dbReference type="OrthoDB" id="10407237at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="159" mass="16939" checksum="DAB3C7AF61E2BDC0" modified="2013-05-01" version="1">MPTPETAAHQTGKAQPKGFFARLLPSKQAQGVVLVAVGGALLWTSIYPYPVKSRTGNPFETPGTQNVQNRFISAGAKDDHQSAVATPLGSQGDVSTPRVQDNKSAMAVSARLKARQMDIGHEESHPNPWKKDDAGPGGAIFPTRPPTATQQSWGETKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y022</accession>
    <name>M2Y022_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_75433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y022"/>
    <dbReference type="STRING" id="675120.M2Y022"/>
    <dbReference type="eggNOG" id="ENOG502S3V4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027589_1_0_1"/>
    <dbReference type="OMA" id="WNASKDQ"/>
    <dbReference type="OrthoDB" id="21072at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040666">
        <property type="entry name" value="Atg29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18388">
        <property type="entry name" value="ATG29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Atg29 N-terminal" evidence="8">
        <location>
            <begin position="61"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME38679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="484" mass="51510" checksum="3986E6B34EBD6741" modified="2013-05-01" version="1">MSPSSSALPVRDRPRSRQSSTATPIAGQAPSKPPSKEKISSRQQSPSNPVQEATKTKIAQYTVFIRLPFIRQNFEDPRPVQWDAAKDRKLWKIISAGKSDLDWEGLSHDFAVDLQFLLMQAAWLSERHMERMKKQVARIAQGDGASSSGTGSAVVGLKMERGGSRDSKMPPGSILRRESPAGEGGLSPGNSTPQERGTISRSPSTTTVTQSKVTGSTTAAARQQPYLQRPNRGSSGSGRRPAPVVTDASRHDYDEDALEHEGESDLDSDDEPVSAAARSQAFRRPLMARKPKSKLGSMASDGDVEGDDEDDDSGGGYLPFAAASRADPAATIRSSPKRMTVAPASAAAKATSSKTKPTREDSTITTATDSSPSSSGMQRKMSTDTEGASDTPSGQHVPRQRSDQPPGPLSPRHRAQLASMSPRSGRDGSEGSPSMGSSFSDLDDASVTQSALEDALMSNMRHQGGSTMASRMSSLRDALGRRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y220</accession>
    <name>M2Y220_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_75150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y220"/>
    <dbReference type="STRING" id="675120.M2Y220"/>
    <dbReference type="eggNOG" id="KOG0703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017628_0_0_1"/>
    <dbReference type="OMA" id="ASWNMGI"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000026">
        <property type="entry name" value="GTPase activating protein for Arf, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056893">
        <property type="entry name" value="UBA_Nbr1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF7">
        <property type="entry name" value="ACTIVATING PROTEIN FOR ARF, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24932">
        <property type="entry name" value="UBA_NBR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="4">
        <location>
            <begin position="14"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="226"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="338"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="385"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="532"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="75915" checksum="7D6A2AD6932C5D9E" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y5E7</accession>
    <name>M2Y5E7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_153987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y5E7"/>
    <dbReference type="eggNOG" id="ENOG502SAJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090055_0_0_1"/>
    <dbReference type="OMA" id="MSWFTEM"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="106"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="152" mass="16864" checksum="254E95717BEBDF66" modified="2013-05-01" version="1" fragment="single">MTFGGFMSEPRGRYEQIISEESNLPSGTQRIGYDADSQVYTLQDPSGTLHTAPKYSTVPINGKKERSAEWRYLAPFIVIIVVVLMGTFRYVNSAGPSHVECLGDLEVYNILKGDTCYDIAQSRETTVDGLHVANPWLKCENLMAGGRVCVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIA4</accession>
    <name>M2YIA4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dotD</name>
        <name evidence="5" type="ORF">DOTSEDRAFT_75414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIA4"/>
    <dbReference type="STRING" id="675120.M2YIA4"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043694_0_0_1"/>
    <dbReference type="OMA" id="PCPIHIQ"/>
    <dbReference type="OrthoDB" id="3633192at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000116">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thioesterase" evidence="4">
        <location>
            <begin position="78"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME38646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="322" mass="35738" checksum="E345A106F6B74F70" modified="2013-05-01" version="1">MSAAVTSAASIGVPKAPHPALNMDIPALDEKQVKRALIAADHDSKKKLKRSRSSQSPSTHPPATSVLLQGNPRQATKNLFLFPDGSGAAASYTHLTLISRDLAVYGLNCPYLRSPQDWKCGPQDLTPLFISEIQRRQPSGPYYIGGYSTGGIAAFDAAQALDKLGEKVERLILIDSPCPIHIQRLPSRLMDYLKRVHAFNSRGRPPPAWVFEHFEANTTNLQKYRPRPFEAYKEPRTHIIYARQGVCESFEAGVPQMEILEEDPKEMKWIMCARSDFGPLGWEKLLNEEEIFVEIVEGANHFGMMRGDAAERLAGCIGRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLJ7</accession>
    <name>M2YLJ7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_180392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLJ7"/>
    <dbReference type="STRING" id="675120.M2YLJ7"/>
    <dbReference type="eggNOG" id="KOG4373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016103_0_0_1"/>
    <dbReference type="OMA" id="DVRSSNW"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="90"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="481" mass="53625" checksum="D3B2C46D691375D7" modified="2013-05-01" version="1">MAGSASAKVNTREDNACEYSTSPTSSADSAADALDSTAVESNDVNVKLAYDIPPQDYRAAVMASPNSSAAFWSHRLYKGADGKRPAVFYCKNFEAAERQARLFAGERILGFDLEWEPQTSTKTGNIKRNVSLIQIAAEDKIALFQIALFKGETAEELMPHTLKTILESANVVKAGVNVVGDARRVRELLKIDMKGVFELSHLYRVVKYSEQDRKNVSFRLVSLAAQVQDILMLPLKKDDNRISAWSRDLNTQQTDYAATDAYAGFRLYHKLNDVRKSMSPMPPMPGFLEQELPLTLGDGTKVYRSTWKPPGHKSAATNKDIPAEAEEDKYFDAVENQDADDLAANLRSLDIAGDDDAATAAPSNRVGTSRQPPRPDTAKLKAADAWVASWRLSLPPDWTVSARSSELRAYHLWHHQGLSLQEVAALCREPPLALMTVASYVMQALKEENLPYDPERLRDPRDILPTSVHRRYQRIFDRIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLU6</accession>
    <name>M2YLU6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_72339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLU6"/>
    <dbReference type="STRING" id="675120.M2YLU6"/>
    <dbReference type="eggNOG" id="ENOG502S0M8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126647_0_0_1"/>
    <dbReference type="OMA" id="TQYVRKG"/>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME42865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="146" mass="16213" checksum="CF61EFEA42340974" modified="2013-05-01" version="1">MQSLRFQMPRAARAFSTTPARPLARMQLIGRLAETPEVFATSNGKEIVRYALGVPQGPRDAEGNRAVSWFRVASFQEGPQRELLCSLPKGTQLYVDADARMDTYEVDDGQKRTSLNLLQRNFETLSRPKQLEGNLEASQAAAGQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2YNM6</accession>
    <name>M2YNM6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 25 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_35850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YNM6"/>
    <dbReference type="STRING" id="675120.M2YNM6"/>
    <dbReference type="HOGENOM" id="CLU_918365_0_0_1"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="303" mass="34638" checksum="8C24D5BE3C985CA7" modified="2013-05-01" version="1">MAKLEVVRRSIRHPGTLNITLGFGAIYVLTEDTSTWRIQGFLAAARAANLKLYVPVQRQLPLQEIYRKLRTTKLEENIAVARLKLNYINFLEEFLHSGHGTVLFIEDDADFDLRIRYQVETLSLVIWEHFSRKRDENTSVHAAAQAYPYGQDIWDVTWLRHYGIEFTANAKVVAYTDESALPKTRLRSNFNEYYGSMRSQYVTPGPQQQRAILGVAPIVTSAQAGEQVSPTTEISKSIRRFRQLCDNMITLSQTICHTYNVLPVSVGEGSNVSSRPQIERTPYFWTPTQPTEPEVEQFYGDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBY9</accession>
    <name>N1PBY9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxidoreductase molybdopterin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_178714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBY9"/>
    <dbReference type="STRING" id="675120.N1PBY9"/>
    <dbReference type="eggNOG" id="KOG0535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_5_5_1"/>
    <dbReference type="OMA" id="ERHHAGI"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="1">
        <location>
            <begin position="53"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="346" mass="39083" checksum="6C34FBEAC1E4C17A" modified="2013-06-26" version="1">MRTEANKHQIGDRTHLEQARIELGEGFHFRAPPDPHKLKSFITHDDELFQTIHMGYAVIDHDLWRLDVHGLVERPYSLTLAQLRAMPSVKQTSFHECYGSPLKPPTEACRRIGNVTWTGVRLRDLLAKATPLPSADFLWSDGLDCGSFADVKADRYQKDLPLSKAMSDEVLVAYEINGRPLDTRRGGPVRLVVPGWFGTNSVKWLCSLKLEKRRSPGPFTTTFYNELVPGREVEGVTRPVWEVEPNSIIVRPSPGEVFTGPEVDIFGWAWSNDGIRDIEVRVDDGHVLVSANVAVREGFEWQSFDRKLKLQPGDYAVTIRATTTNGVQQPISDRRNHAHTVHFTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDD5</accession>
    <name>N1PDD5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_27245</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDD5"/>
    <dbReference type="STRING" id="675120.N1PDD5"/>
    <dbReference type="eggNOG" id="KOG3482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_12_3_1"/>
    <dbReference type="OMA" id="DNYMNFQ"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990935">
        <property type="term" value="F:splicing factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME40613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="89" mass="10131" checksum="9313F06DCF5D6238" modified="2013-06-26" version="1">MSFIPLNPRPMLQSLVDKEVIIKIKWGQEYTGKLVSVDSYMNIQLSGCSEWKDGQDMGVLGQVLIRCNNVLWISARNQKQENGDAKMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDI0</accession>
    <name>N1PDI0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="9">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="9">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA1</name>
        <name evidence="10" type="ORF">DOTSEDRAFT_75729</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-HAO family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="9"/>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDI0"/>
    <dbReference type="STRING" id="675120.N1PDI0"/>
    <dbReference type="eggNOG" id="KOG3995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095765_0_0_1"/>
    <dbReference type="OMA" id="KPPVGNQ"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000093">
        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME38260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="208" mass="23308" checksum="17F958A3B8C6DF26" modified="2013-06-26" version="1">MPASLATRTSRASFATAVNSQKPLGLPLNLPKWLSENSHLLQPPINNYCVYNDPMTVMIVGGPNARTEYHINETPEFFYQYKGRMLLKTVQQVNGKEEFVDVYINEGELFLLPANTPHNPVRFADTVGVVIEQPRPESSLDRLRWYCDNCGDVVNEAAFYCTDLGSQIKEAVNNFKADEAARKCKKCGTVCDTAPKPEAMERMRTAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDQ9</accession>
    <name>N1PDQ9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP binding protein of the Rho subfamily of ras like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rho1</name>
        <name evidence="10" type="ORF">DOTSEDRAFT_75922</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDQ9"/>
    <dbReference type="STRING" id="675120.N1PDQ9"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OMA" id="EVNHYIP"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME38569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="192" mass="21737" checksum="D03C93816AFC2888" modified="2013-06-26" version="1">MAEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGKHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAIDSPDSLDNVQEKWISEVLHFCQGLPIILVGCKKDLRYDQKTIEELHKTSQKPVTPEQAEDVRKKIGAQKYLECSAKTNEGVREVFEHATRAALLTRKKEKKKCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE78</accession>
    <name>N1PE78_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_27279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE78"/>
    <dbReference type="STRING" id="675120.N1PE78"/>
    <dbReference type="eggNOG" id="ENOG502S4MP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041458_1_0_1"/>
    <dbReference type="OMA" id="VCSIHTD"/>
    <dbReference type="OrthoDB" id="3886346at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="371" mass="40804" checksum="AC9D97BA1DAB0A69" modified="2013-06-26" version="1">MADEALDSFKALLQSVPGWIADLESILKQAADRQEEILFETHPGPREHSPRETPKPKSKSSSLKSSRSHHDSTGQGDDRSKPTLLKRRSLKHLTSSDALRLSQRKRKTTSVASVDQSGPPKFRTKAAAVVYYDGDTQKRFEKLVRAVGSSRNAIRKGKMGAKVDCLGRTGSSSSEASNSSGGEEDAFSPLAARLNIKSTRSPRPGVILGRNADTEVFDKVDAKLERAQALCERAAHQILRDGDCTLEVTNARENFAEAVQLAEEELPTLQKRAEKAAARRRRSEERHSVEEEEADAKAEAHAEAEQKRRSDLSQQIIHAVVAAGYASEPKLEVDRSEADDLDDDEGEFDIGAMKMGRFTHMRRSPLPIAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFL5</accession>
    <name>N1PFL5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_74819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFL5"/>
    <dbReference type="STRING" id="675120.N1PFL5"/>
    <dbReference type="eggNOG" id="ENOG502SP7J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019833_0_0_1"/>
    <dbReference type="OMA" id="RFAEYKF"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="707" mass="78438" checksum="EC6A618C3D0CE9C7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFL7</accession>
    <name>N1PFL7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_36605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFL7"/>
    <dbReference type="HOGENOM" id="CLU_1610722_0_0_1"/>
    <dbReference type="OMA" id="HHTHAIP"/>
    <dbReference type="OrthoDB" id="10474111at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="165" mass="17731" checksum="6C4775C510A93BBD" modified="2013-06-26" version="1">MALSRKVSIRGLPQQCHSHHPTTSAQNNGKSTFRRLATTSVANTTSLIRYMTLREVATSKAMTVGADAAFRKEILEAAKQIALSACIMDGPDSARAAELAHAAWSVVFIPGVTFESEKEVEQASAILELASGILSEAAEGDGDLDEDEEWDPNVVSNELGKYHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGV7</accession>
    <name>N1PGV7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGV7"/>
    <dbReference type="eggNOG" id="ENOG502SHP9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_13_3_1"/>
    <dbReference type="OMA" id="WNEPKPE"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="61"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="573" mass="65896" checksum="23141122FD9090C0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHR7</accession>
    <name>N1PHR7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_37014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHR7"/>
    <dbReference type="HOGENOM" id="CLU_1320869_0_0_1"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="208" mass="22420" checksum="660A0879AE96567A" modified="2013-06-26" version="1">MSESRWTAPGRQPLKLALPTFCARRRTTNTHTAGASPNSPREAHAESAKAVRHMESQLRLASPHVSIGLQRAPYSLLPAEGALTYTHIPSPDVCALDFPTVFTNTSLWTSKGEFFISGAVADIMRNSGTMRANDVAVAPVTGSTNAHTRYLTREVPNIKVGFFCVGASPSENNAQELAAASLKPSMTRVRLNQHRIGLHNGSATHGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI57</accession>
    <name>N1PI57_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_134489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PI57"/>
    <dbReference type="eggNOG" id="ENOG502S79M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177978_0_0_1"/>
    <dbReference type="OMA" id="ARTHHIY"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="107" mass="11888" checksum="3606CF1A01B10033" modified="2013-06-26" version="1" fragment="single">SISALGRSTVQWFNKEKLPADYQKAAENYIANGAVKALGEIQKVEILHRNDGSSPVHKSSFNRADKAEIVSARIHPVKGDPRTHHIYRDGTGTIKKGDKREYSTSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIB3</accession>
    <name>N1PIB3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIB3"/>
    <dbReference type="STRING" id="675120.N1PIB3"/>
    <dbReference type="eggNOG" id="ENOG502QPJI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057759_0_0_1"/>
    <dbReference type="OMA" id="NHWPLRE"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052963">
        <property type="entry name" value="Pantetheine_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36492:SF2">
        <property type="entry name" value="[ACYL-CARRIER-PROTEIN] PHOSPHODIESTERASE PPTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="311" mass="35701" checksum="264ACC94113F5338" modified="2013-06-26" version="1">MQLWAIADIHLSFKSNRDEWQKLMHKEDDGLILAGDVGESLDHLKEAFRKATRRFKFVFWVPGNHELYTSSSPSISDKEKKLKGESKYKACVKVARHYGVLTPEDDYMTWPYTSADGTQERALICPIFTLYDYSFRPEHVTREKALDWALEEGIQATDEKLLHPDPYATRDAWCTRLVSEAEAKLEKAAATGLPLVIINHWPLREDTVFIPRVPRFSLWCGTKETNDWHTRFNAKVVVTGHLHVRRTDWIDGVRFEEVSLGYPRQWQDAKNVGNDVNSMLREILPGPAPPPPGQVPPTLYRRLGSGEPICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ77</accession>
    <name>N1PJ77_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_112459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ77"/>
    <dbReference type="STRING" id="675120.N1PJ77"/>
    <dbReference type="eggNOG" id="ENOG502SM08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040048_1_0_1"/>
    <dbReference type="OMA" id="FCGEFGG"/>
    <dbReference type="OrthoDB" id="3649172at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36337" checksum="9D9686284DFD1A22" modified="2013-06-26" version="1" fragment="single">AILRVSSYHRRDYDLAVICLAERDHAVITTISSLQRNCSSSLGVLDQLPVELIDIVCLELDLASLFALRHVSLRGRQIVSALPEFKLITKYAVSCLHAMLRTGTASGICLCTLWHLFCTSVCSTCQKNFGNTLHLLTWKRYCTTCLRGRVHKSAVMTVAHARKQLRLRAPTLRRLPTLKTIPGIYTMEETLHKSSVHLIAEYHAFSSYRDEHGGAEPAIVRREQQSRNVFMSCCAFPSYDTLTRDVERGISCSGCQLISENQDGLREDLVFLRDKVYSKASFLKHYEECEGAQRLWNSSDDGKVQPAELPAWCKIGGYFSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJW8</accession>
    <name>N1PJW8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_45957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJW8"/>
    <dbReference type="eggNOG" id="ENOG502TACQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1777392_0_0_1"/>
    <dbReference type="OMA" id="YANDMHA"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="146" mass="15974" checksum="D1167E10476C7CB8" modified="2013-06-26" version="1">MTSYQDDDTQSLISTVSVPLPSAPPPTGPNTVVGVELPTADEIGRLLIFSDTFRIARGTPATSAVATQDVPKPPVTEAEERGGVPENTVWPEVVDEKIVDGMKRLAQYANDMHALDPSKSVEQYYGERLAKLLREGEVKFNMEFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKB9</accession>
    <name>N1PKB9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rad4 beta-hairpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_171899</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKB9"/>
    <dbReference type="STRING" id="675120.N1PKB9"/>
    <dbReference type="eggNOG" id="KOG2179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003639_0_1_1"/>
    <dbReference type="OMA" id="TWPGKTK"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="633"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="693"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="763"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="897"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1001"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1022"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1128"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1139"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME43957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1155" mass="129227" checksum="5AAFF3362D45A4FB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKY6</accession>
    <name>N1PKY6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_24233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKY6"/>
    <dbReference type="HOGENOM" id="CLU_1229904_0_0_1"/>
    <dbReference type="OMA" id="EMAYSAR"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="225" mass="25387" checksum="773ABD1F26E2EFD4" modified="2013-06-26" version="1">MGTASFGAQFDYMERYEMAYSARSVTKPSSIPNDSLSHLPGMTQNDQQASGPTPKLKTTTSSRDGQTYDSPMPWNTVDCMTPASRSPGAPSCSAVGPLQTVIPASYNSEDDEQAINRPLHRTPSESGSTCFPDPSFLAPTARIRHDSGYFFEENLHHLKIEFRKPLPVGHPERVDDLGLRTVCSIEIRKRKWKTGCAFKRMLSKMSRRVGRWRDEMWREERRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL94</accession>
    <name>N1PL94_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_34622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL94"/>
    <dbReference type="HOGENOM" id="CLU_1578498_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="169" mass="17864" checksum="3ABB9DAF5111C532" modified="2013-06-26" version="1">MEVSAFIDASTVPRNPVLDLWSACGAAGIFTAPHVASARRNTDDSTMRALVSGGDGSGALLPSSCQIALRRTAKTQASSPPRGDPYTHGTAQSTALASLRTHCGTDFSDATEFLHQDRDYDDGDTAGVRSDHKCRCASMSRAIQQGHGADRHLLLSMHAKKLPDGAWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLG2</accession>
    <name>N1PLG2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_71847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLG2"/>
    <dbReference type="STRING" id="675120.N1PLG2"/>
    <dbReference type="eggNOG" id="ENOG502QRKD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028484_1_0_1"/>
    <dbReference type="OMA" id="LPFAPNM"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000002">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME44166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="501" mass="59001" checksum="CCA09F2AC77A6AB2" modified="2013-06-26" version="1">MRLACMECPAVNRLFRRLATHRFCHEGPSTCAPVARAQWRHQSTRTLPSGKKVKTTVESSWQQRTDHFPSDKAEEFKRYPNVTSDQLRLRRERPRRVKMLLRDFIEDSLYNPHYGYFSKNVTIFSPGAPFDFNKLRDEPEFYKLLGERYTQFEDKLDEKEYNEARQLWHTPTELFRPYYGEAIARYMVANYKLTLYPYHDLVIYEMGAGNGTLMLNILDYIRYTDPEVYARTKFRIIEVSSALASLQAQKIQATASSRGHHDKVEIINKSVFDWDLYVPTPCFFLAMEVFDNFAHDVLRYDPFTEEVMQGSVLIDSEGDFYEFYSRTLDPVAARFLRVRDAACQDRQYPHPLRQSKILRSIRHRLPLAPNLTQPEYIPTRLMQFFQILSTKFPAHRLITSDFHSLPQAVDGYNAPVVQTRYQRRTVPVRTPLVQQGYFDVLFPTDFGVMEDIYRAVTGRLTRVMTHEDFFQRWAYVEDTQMRSGENALLSWYKNASVMLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM09</accession>
    <name>N1PM09_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_24551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM09"/>
    <dbReference type="HOGENOM" id="CLU_2061425_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="119" mass="13387" checksum="406FAF8808043A51" modified="2013-06-26" version="1">MLKSPVLPNAHSRSKGVALKPSVHRPEDQDHSPAEFNPSSRRHSTGDYADKMVERHQDTSNPIGEEAKSRAVAAKNQRKELEEMTEDETDGFTDEGLEECEREAEEELQRESVLQLCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM80</accession>
    <name>N1PM80_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_34994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM80"/>
    <dbReference type="HOGENOM" id="CLU_1704200_0_0_1"/>
    <dbReference type="OMA" id="RINDEWA"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="154" mass="17183" checksum="CF1A9CAC6787E499" modified="2013-06-26" version="1">MTVKHTNHSVEKTPISRILTKAHTLLKVVKSPNSSTTCKGVCHFLQIPKEVWTKIYGLVLADCNQVSQLPLLRVAPRADVCYEQSIPSPLLLATCHMIRKELDTLYLEHLKRINDEWAANFGAVTEQMHRLDAMGRLEEAGGTLFSGGDDDEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMK0</accession>
    <name>N1PMK0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_72172</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMK0"/>
    <dbReference type="STRING" id="675120.N1PMK0"/>
    <dbReference type="eggNOG" id="ENOG502SSI3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147541_0_2_1"/>
    <dbReference type="OMA" id="RSKWFGA"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.49.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT VIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME44622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="77" mass="8986" checksum="FE8C992FC36711EA" modified="2013-06-26" version="1">MFARTAAARFPTQAISRRGFSTTRQQLASPYHYPEGPRSNIPFNPLTRFFYLRYWGFMLVGFSAPFGIAVWQTYKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN51</accession>
    <name>N1PN51_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_71995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN51"/>
    <dbReference type="STRING" id="675120.N1PN51"/>
    <dbReference type="eggNOG" id="KOG0199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006696_0_0_1"/>
    <dbReference type="OMA" id="IRIYEAI"/>
    <dbReference type="OrthoDB" id="635774at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF4">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="341"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="690"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="878" mass="98952" checksum="98F3E524F7C68D09" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPA1</accession>
    <name>N1PPA1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_24749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPA1"/>
    <dbReference type="HOGENOM" id="CLU_1669359_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="158" mass="17885" checksum="7EFA2D02A254C1BE" modified="2013-06-26" version="1">MCRKSRIAKSQRQCWNRRKRKGSVQSKEFPPASYPRQVADIKPAVNAEKVSEPCAAEKDAGPKKRKAENCAVKRESSKKSKNDPRHRQWTIRNMVRRRVAQLERLRAAGTGQDLDLNGFGDLDLQKMTDRAVRALQDGLRKVNHEADRKGGGPPQRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPH1</accession>
    <name>N1PPH1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_129926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPH1"/>
    <dbReference type="STRING" id="675120.N1PPH1"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_5_0_1"/>
    <dbReference type="OMA" id="NCRKVIC"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME44280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="235" mass="26080" checksum="A0F0D350411DA491" modified="2013-06-26" version="1">MASLAAIKQNCRKVMCVGRNYADHVTELNNQRPKQPFFFLKPPSSILLPNEGPILRPAGVNLHFEVELGLVIGKTVRDLDENDTEGWMDAIESYILTIDMTGRNVQEEAKKRGLPWSIAKGFDTFLPVAGPVQKALIKDPHNVELWLSVNGQMKQNDNTELMLFRIGRQVSDISKVMTLEKGDIVLTGTPKGVGTVVTGDVIEAGLMIDGKDVEEARINVDVKDRTGPYEFTPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ01</accession>
    <name>N1PQ01_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_129687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ01"/>
    <dbReference type="STRING" id="675120.N1PQ01"/>
    <dbReference type="HOGENOM" id="CLU_004184_6_0_1"/>
    <dbReference type="OMA" id="VDRICIN"/>
    <dbReference type="OrthoDB" id="3650563at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="39"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="206" mass="23603" checksum="0626496BC9C4DFD6" modified="2013-06-26" version="1">MTALYNPLEPDHVRLLRFTDSTGLHANISEHSVRDAPPYACLSYVWGEEDGLLDTDDTPYVVVNGHPSRVQRNLLEALATLGKVVVSENLHFWVDRICINQSDLDERAKQVKLMKLLYEEAKRVLAWTGAANAETDFLACRMLSTIGSFSRQLLNMTRTRPTLDWLLRLIRASPEFHEASTELILKSWAAMIALLKRPYWARTWIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQB0</accession>
    <name>N1PQB0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_34092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQB0"/>
    <dbReference type="eggNOG" id="ENOG502RP5X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1517824_0_0_1"/>
    <dbReference type="OMA" id="CSQGHGA"/>
    <dbReference type="OrthoDB" id="3649780at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109262" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="18395" checksum="8FF27FABD68DA41E" modified="2013-06-26" version="1">MSIKLISFAFLTLSTRPGAMSSPLKQAVIAPNTAICDFSLCSQGHGASMGCYNIRIGRPFIQGGGCPSIQQNLRNGITYLANYHCQDDGSGQTSLSFNTPADPASNIGAIEALQKSYPDVPFESERICLMDGNTVPASWPPEITCPIEPLDSAADVSATASGTACGAGEGVENGCDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQC5</accession>
    <name>N1PQC5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_34110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQC5"/>
    <dbReference type="HOGENOM" id="CLU_1917024_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="132" mass="14802" checksum="0C2B7EBA0CF1117C" modified="2013-06-26" version="1">MCLGCSGNNCNGAAGAIQEVTAKGRCLEASGRHSYRVSACYEMSQVRNHVSEPHPSRAKVTNFNIPTEPYTEKGTTVVRLEAKELAQSDRAVAKLPLPWRKLGHNVNTRFSWGNFEVQQFLSKQQIEKHRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQC8</accession>
    <name>N1PQC8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_71002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQC8"/>
    <dbReference type="STRING" id="675120.N1PQC8"/>
    <dbReference type="eggNOG" id="KOG2624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010974_5_1_1"/>
    <dbReference type="OMA" id="WRMYNEI"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000095">
        <property type="entry name" value="Triglyceride lipase-cholesterol esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="133"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="475"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="570"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME45143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="599" mass="66937" checksum="2819864BA040589F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQU2</accession>
    <name>N1PQU2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_152827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQU2"/>
    <dbReference type="STRING" id="675120.N1PQU2"/>
    <dbReference type="eggNOG" id="ENOG502RUV2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037358_0_1_1"/>
    <dbReference type="OMA" id="CNNYVEF"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109270" description="PLC-like phosphodiesterase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="51862" checksum="64EEC7B5ADCE71FA" modified="2013-06-26" version="1">MMPSALWLLCLAVATRAQDTTSTASSGSSGSSGSSTTSSESQSSTASDPNFSFTNALSTISGGVPTSAFTGSEFIYLSPTAQSTVQTLTETTSINGSLTTYTTTSSASASSNSQITVSSKSVSLTQLIGATQNSTSNSTASSTSSAAQPTNTVPCNGYPELCNRQYSNITQVAAHNAFFVIKNNAASNQDLSVPTQMNDGIRMLTGEVHYVNDTLYNCHTSCELLNAGTYESGLVTVREWLQSHPYDVMTLLIVNSDFVAVENFTAPFENAGLTPYLYTPSYIPQYRNQWPTLGEMILRNDRLVVFMDYQANQTSVPYILDEFTHMWETPFSPQDQAFPCTQQRPPNLNQTVARDQYMYLANHNLNTAIDLSSIGIDTSDVLVPNTADINQTNGQQNEYGRLGEMNTNCTETWGHPPNWLLVDYYNYGSPEPGSVFQVAASANGVTYNKQCCGLATSAAPLVRISSAGLGVAIVVAMFMTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR00</accession>
    <name>N1PR00_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_129126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR00"/>
    <dbReference type="eggNOG" id="ENOG502R8E9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1366228_0_0_1"/>
    <dbReference type="OMA" id="TERWYPP"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22132" checksum="6AC8625ED757FD77" modified="2013-06-26" version="1">MTRNSSPSIHSLHAKPSPRALKKHLRDLNGTWSLSKALSSGVPPALELQGFNSATRKAIIASPMSLWISQSNYPSQIFAKETTTTSIPTRTERWYPPHNGSWSEWWTTSSAGMAGGYISTRSRCKWIRGSEVEHGEGMGFLTEGLSMSGEYLIAEVECAELGWKAKQIWSVDRGRLVRRVVTSGEGEKRAETILVYNFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRA5</accession>
    <name>N1PRA5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_70819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRA5"/>
    <dbReference type="STRING" id="675120.N1PRA5"/>
    <dbReference type="eggNOG" id="ENOG502QUK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022730_3_0_1"/>
    <dbReference type="OMA" id="NDIPCEW"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF129">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="503" mass="54648" checksum="A06838E813D45B4F" modified="2013-06-26" version="1">MPASQPNIAKHRKPCDLPSPNSTKSFWHREPSALLLGHRSTRSPPETADVVVVGSGITGASVAHHLLTTCDSGHKLDVVLLEAREACWGATGRNGGHCQPILFEHPHDSSIGHFELKNFETLQSLIDEKKIDCEFEVQPGVRGIFSRGHLDQAELAMHIVQNNAPELASRMKLVVDRDELTGLRLPTALGAIVTNVAARMWPYKFVSRILEDLVTSTKLQGTFNLQTLTPVTKLAPAAEEFDADRVLVTTNRGIIKAKKVVLATNAYTSHLLPGMSDLIVPCRGQMSALVPFPSISGEDRLKTSYGFLGDGLDDYLIQRPNERGAHLMFGGGRQHGPSMGTTNDNQLDEKTASYLRGRLVQVFNLSEGGGKTSWAEMDATHEWTGIMGYSRDERPWVGAVPQNFSPPLPSGSTYIAAGFTGHGMPNTWLCGRAAAIMVKEAFAGASEDEASAAASKETGLPEAYKISEKRIDAAMQLEGVEAKDWAEMERGERARRPSTSGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRI1</accession>
    <name>N1PRI1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRI1"/>
    <dbReference type="STRING" id="675120.N1PRI1"/>
    <dbReference type="eggNOG" id="ENOG502QTWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059767_0_0_1"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="269" mass="29315" checksum="3CBEE13274A728CB" modified="2013-06-26" version="1">MISGLEALGPIEQEDQRTLSVDELPLLQADLVWGDIVRGCQISQLPRLSLLAITMLPSSKKATYGRPVTPPIPPHPSVVQRRMELLTSDMLSRALSLVSRGQHERAHHLLSETRSILKGLGKGGLPPLPAPAPNGALPPTPRVPEHKMSALDANFPPPPPSSRGPSSPFESEPSSPFVPAAGIDRSTMLGLDMELGSSLEWICHPAVFSRDARKAVLQAIGVVSSQRGYTFRTTSEALWAGRIPGVRRLTDRSRDWRQAGDEHIMEEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRS6</accession>
    <name>N1PRS6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_22201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRS6"/>
    <dbReference type="STRING" id="675120.N1PRS6"/>
    <dbReference type="eggNOG" id="ENOG502QTQ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2209946_0_0_1"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12081" checksum="325C5A174233AA54" modified="2013-06-26" version="1">MARELLKSGKHNITAIPRVDSQSKLADGVNIKHIDYDKHGTIVGVLHGRNVRIITLSIPAHHSESKFVQEACGTGVPWIIPNDWSPDTADESLVRDVPYRLYSWRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSE1</accession>
    <name>N1PSE1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_23332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSE1"/>
    <dbReference type="eggNOG" id="ENOG502THWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1054219_0_0_1"/>
    <dbReference type="OMA" id="CEWHVHE"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="261" mass="30026" checksum="D5D8D741981BC447" modified="2013-06-26" version="1">MSPPASTPGSEPKWDPFGPSFVVLIGGGTTQTIFKVSESFLAHYSGYFRTMTSNTIMSPILPYSSDAEIRLPGDDPEVFSMVLHYLYHRRFLDSTIHPCHLLSFDKIIDIWSFGEARVIPLIQNAVADLFGDKIKLSKSLPDRWSIEYLWERTEKGSQLRKMLVALVREMWMPDGHKHTIWGELVDGRSEDPERLVWLVEALLDSKHEVRVSAKARRRMESCEWHVHEDFVWCEGSEEASLDDQRDLMAAKRRERAASWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSM9</accession>
    <name>N1PSM9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_23406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSM9"/>
    <dbReference type="STRING" id="675120.N1PSM9"/>
    <dbReference type="HOGENOM" id="CLU_1555218_0_0_1"/>
    <dbReference type="OrthoDB" id="2446250at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="172" mass="19716" checksum="54D9841D31AFFEC4" modified="2013-06-26" version="1">MPIKVYWARRNAWDLGKPIWEVWSDKDPGIERRMGGFTGEPRFEADTCFCVQHNQFEEEVWASWAITPVPGPSGNLCYYNPLTEQTQQVLYDRRMGALMALEHNTLQLDDITMLWARIMKSLELNRADVPFAAVYSHKSSSHRFAKPEPVDWHPDAGDVMSRNSSNTGASIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT01</accession>
    <name>N1PT01_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_108068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT01"/>
    <dbReference type="STRING" id="675120.N1PT01"/>
    <dbReference type="eggNOG" id="KOG2809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082196_0_0_1"/>
    <dbReference type="OMA" id="MRAFDQG"/>
    <dbReference type="OrthoDB" id="3366546at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF33">
        <property type="entry name" value="PROTEIN TMA23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14213" checksum="19E5F58F431C221F" modified="2013-06-26" version="1" fragment="single">MDAASYLKRQGWRGDGHSLDQTGRGISRPLLVSRKVDVLGVGLNKHAAVSDQWWMRAFDQGLKDLGTGKRTALADVREKGHLYGGLYGRFVKGDGVAGTFETPTPEDSGVEMPKAVIRKRKRDDQSTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTE3</accession>
    <name>N1PTE3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTE3"/>
    <dbReference type="STRING" id="675120.N1PTE3"/>
    <dbReference type="eggNOG" id="ENOG502QRGK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045411_1_0_1"/>
    <dbReference type="OMA" id="LYIHSRT"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="40227" checksum="0E71D7D1D8119126" modified="2013-06-26" version="1">MTQSTSSYTRPPVITVSLQDLEHGNVSLEALEQAFGPDSLGIILVKDLPEAFAALRRKLLSLSSYLADLPAEKLAQVERPEARYNVGWSHGKEKLDSGLPDLNKGSYYGQPIHNAELEAKARTLYPDLPDMTLENVWPDESVLPGFASTFEEMCRLIIDVAALVARSCDRFGVASLQGYKAGTLENIVKTSISTKARLLHYFPPPPSRAAQGRPDSALGKTDDGWCGTHVDLGALTGLTSNLFVDESAHPPKAGQDGSLPDLPELDNHPDPEAGLWIKDRSGRTTQVNIPRDCLAFQTGQALEKITRGRFRAVPHFVRGGNPMVEGSRGIARNTLAVFTQPNLWEVVEEETGMDFADLAKKMFERTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTK0</accession>
    <name>N1PTK0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_150914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTK0"/>
    <dbReference type="STRING" id="675120.N1PTK0"/>
    <dbReference type="eggNOG" id="KOG3080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036007_2_0_1"/>
    <dbReference type="OMA" id="DAHKGRD"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000280">
        <property type="term" value="P:nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME45685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="397" mass="44341" checksum="8C2D78363EF091A4" modified="2013-06-26" version="1">MGVNYKLEKQKKLQKEADKRKRQKQRFEIDVDALEDSMSDDGSGGDIQPAAERKKESKAAKRADKAEAVNGDAEGWETEESEDAGDEEGLENDDATGGVEIEGEMEDESDSDSELGENERQDDEDDEDIPLSDIESLASEDRADVIPHQRLTINNTAALQRALKSFALPLSLPFSANQTIVSAEPVQIADVEDDLNRELAFYRQSLDAVTEARSRLKKEGVPFSRPTDYFAEMVKSEEQMGKVRAKMLDEAARKKASADARRQRDLKKFGKAVQVAKLQERQKEKTKTLDRINTLKRKRQGADLTANEDDRFDVALEDAATTQSKDRAAKRAKSAADGPNRKRQKKDEKFGFGGKKRFSKSNDAKSTNDDRSYSQKRMKSGGKGGKPRPGKSKRAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTL4</accession>
    <name>N1PTL4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_125535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTL4"/>
    <dbReference type="STRING" id="675120.N1PTL4"/>
    <dbReference type="eggNOG" id="KOG0700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021928_1_1_1"/>
    <dbReference type="OMA" id="TCVSRWL"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="429" mass="47638" checksum="E209827888CC34FE" modified="2013-06-26" version="1">MTVEAATELLETRSGYAITPTTVAHTSQLPSNMPCEDTWSCGAYTFNGDRTKDWDEWGIFDGHAGSRTAQLLKHFLPSIVGGELWDSKCMDRPYVPNDRHIINSIKKAFIQLDKDIVDEAGKLLLAGGPLAEMVACGAAAFSGSCALFALYDPVRSVLRVANVGDSRAVLGRWDASKAEYVAQAMSIDQTGFNENETARLARDHPDEDVVDPKTGRVNGMAVSRAFGDARWKWPQSLTRLAHDKFWGPSPRPDSMIKTPPYLTAEPEVMETRVQTGDHPDFLIMASDGLWDQMSSEDAVTCVNEWLKKNKPTNFLDQVKKNLSVADLLGRGGPPQPPGMRKLTESPADEDTYYDEDEKCLKWRISPKHFIVEDENCGIHLIKNALGGKRRNLFTGVVSVQPPLSRYVRDDITVHVIFFGQDEQSAVKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTQ0</accession>
    <name>N1PTQ0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_52936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTQ0"/>
    <dbReference type="STRING" id="675120.N1PTQ0"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1151778_0_0_1"/>
    <dbReference type="OMA" id="QECANTA"/>
    <dbReference type="OrthoDB" id="5386922at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="99"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="241" mass="26297" checksum="51344BE91A974563" modified="2013-06-26" version="1">MSLVVVGWDCGKAGFNLCTPRAPDPVFPSRPVFGSVNHDPSSTAAIALVKKWLECCHTDHQECANTANAPLPTRTLDVQSSTLTGDIKLYCSKSEQATYLALSYCWGGIVPLHTTSHNLEDHKRSTPWTDLAPTFGDYARLARLLGVRYVWIDALCIIQDSAKDWDCQSAQMASIYSNTDLVLIAANAPSVSAGFLHLTQATASVGRRQSHGESERTDSRAPSRVCRAHLNDGPRREAGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTT1</accession>
    <name>N1PTT1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_78938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTT1"/>
    <dbReference type="HOGENOM" id="CLU_1586435_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19095" checksum="3CB5CED5A5FDD1D4" modified="2013-06-26" version="1">MEAADSAVKPECYELRLVKKRLLFLTDDHSDLGTDPPMQCRCDPETHNTRWPGVPFAKLADFDIGILQGNDNADIPGTLTPGFDAPEQYDYSKAVRPRPDLDGTGVSHKSNIWSVGKTMMNLINLQYEGDPDYVDGKYDESWRPNRLNIQNALDLYEAYAGWPLLRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTX9</accession>
    <name>N1PTX9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTX9"/>
    <dbReference type="STRING" id="675120.N1PTX9"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030125_1_0_1"/>
    <dbReference type="OMA" id="LYGKYHV"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF0">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="29"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="400" mass="45541" checksum="B79D425A83A60A25" modified="2013-06-26" version="1">MLSARSRHTVLSLLQNSKCPEDCKMPRVALITGANGITGTALIEHLVRNTTSAEWSRIVITSRSPVKLLVEDPRLNFIALDFTDHHEAVAQSMAESCKDVTHAYFSSYIHKDDFAELTIANKALFENFLQALTLVAPKLENCTLQTGGKYYGLHLGPVPTPCREDEPRRGDPEENFYFPQEDRLAEKQEGQQWTWNVIRPEAIIGHTSKPNGMNSALTCALYFMICRELGEEARMPTNQVYWNGTETNSDAPLLAKFTIWASTTPNCANQAFNFVNGDHFTWRYMWPRLAEYLGAQTSSDQNFDKSMPPQGEVQQEFSLAAWAEDKKYVWARICDEAGVPEAKSTFDAGTWAFQDWVFMRTWYPNLSMNKAKKFGWTGFIDSYDSMTTAFEKFREVRQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTY7</accession>
    <name>N1PTY7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_87280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTY7"/>
    <dbReference type="STRING" id="675120.N1PTY7"/>
    <dbReference type="eggNOG" id="ENOG502QVGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_1_1"/>
    <dbReference type="OMA" id="TWFYAKS"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF17">
        <property type="entry name" value="OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="57"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME46847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="486" mass="53047" checksum="CC15F1D109F39E78" modified="2013-06-26" version="1">MLPTRSTTPFEKCIAQAFGEDSSLYTFRGDLISDLPLVDGLPYLNNLESEHPYNLDHPVTPAAIVFPRDAQQVSAAVMCARKYGIAVSSRSGGHSYTNAGLGGMDGALSIDYQNMKAFSYDPQDQTMTFESGSRLADLDRNLAPTGRVAAYGAVGSIGTGGHFTIGGLGALSRLLGLAADQIVSAECVLADGTVATVSADKNTDLFFAIKGAAWSFASVTSFKVATSPAPSSVISFQYNITFSRIADLADSFSQWQELVSQPDLTRKFASTLTLAQDLLVYSGTFFGDRSDFDRLNLEGLLPHGQEHLDITVVSSVVTHAITDLIKFGYDIFGSLPAHFYAKSLKFTRQTLFSSSAVQELFQYLDTIDKGTLVWFIVWDLNGGAISDIPQDGTAYWHRDALFFQQGYVVNEIGPVTQQSRDFLTGLTDEIHRLQPRIDDSAYPGYVDAELENPLRAYWGGNVERLIQIKGEYDPDDVFRNGQSVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU53</accession>
    <name>N1PU53_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_50495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME46986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU53"/>
    <dbReference type="HOGENOM" id="CLU_950022_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="293" mass="33533" checksum="6F796E8EA925DF1B" modified="2013-06-26" version="1">MPNPFAWANDEENNGSYDTDDERPTDPRPRSQFLMAAPSQVNATAHWRPNSITWHGAAELIYGRPQHEHRLDPERPWWDMLEGDRDMMRLWDLAIQDLTPFDQMSPETRVWMLRALNEESLELLGVNTRAFQVPRRAAAPALDQSLFDPHMAMAIDWINRDHDYFDPAPFNELPSVVSTLGSRFRPLTMHLTAHTTTMIGHLTLPMLGLKQISSPTRTNQCPCTQKSKNWMIGKDNMASIGPYSRQNAISSLWRPTSTMPMPLAPSARTKKKITLIRSWSMSFKITPSMHPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUF8</accession>
    <name>N1PUF8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_147844</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUF8"/>
    <dbReference type="STRING" id="675120.N1PUF8"/>
    <dbReference type="eggNOG" id="ENOG502S17A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_5_0_1"/>
    <dbReference type="OMA" id="HYLRYHH"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="13">
        <location>
            <begin position="53"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME45995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="282" mass="30175" checksum="C3DB0419800E81E9" modified="2013-06-26" version="1">MSDIGELQTDEKTFLEPYLPQHACNTTEHETDTSRSRSSDCLDSAAAEDSDLPFVTLTYACSLDSMIALAPGARTTLSGPQTKCMTHFLRFRHDAILIGAGTAATDDPALNCRYPGVTLSDQPQPVIVDPNGRWAVQDKKATRLAIDRAGKPPWVVARHRTTSADPLEAVGGELLLFEQDASEALNASSISWHAILRALKRKGIQSVMIEGGATIINALLALPDVVDAVIITIAPTFLGQGGVAVSPLARGDANGRVNAAWLQQTCWRQFGNDVVLCGRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUN4</accession>
    <name>N1PUN4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_43130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUN4"/>
    <dbReference type="STRING" id="675120.N1PUN4"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="OMA" id="RSWFHYI"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME46653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="37859" checksum="7A4E26A4982E249E" modified="2013-06-26" version="1">MSFAPKEPYQPYAALHAETKGPDDQRPNALQIVKDLNATGKLKGKTVLITGCSAGIGIEAARALYETGAKLFLTARDVPKLQKVIEDLVSNGQNKDTPRPEALEIHLDSLQSVRAGAEEFKKRSTQLNILINNAGVMACPYGTTKDGFETQIGTNHMAHFLLFQLLKPLLLQSASKDGMASRVICVSSAGHRQGGINFSDINYAKPGSYQKWVAYGQSKTANIYMASSIERHYGSQNLRGLSLHPGEIQTELGRHLNQDDYAALGFDKWKNIMKSPAQGAATQVWAALEPHFEKGNGGRYLAECGECGPMAEGARTGSEGYSAHVYDAEAEEKLWKLSYEAVGLPVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUV1</accession>
    <name>N1PUV1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_70244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUV1"/>
    <dbReference type="STRING" id="675120.N1PUV1"/>
    <dbReference type="eggNOG" id="ENOG502SDBT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1517823_0_0_1"/>
    <dbReference type="OrthoDB" id="3628202at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME46189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="177" mass="19908" checksum="3139869A4319A206" modified="2013-06-26" version="1">MWVVHFVGDVAQPLHTSGTKYGGNGEKVLFNGEKSNLHEVWDRSILLAGTRRTDDFGDLGLDPYFGALLERIQKDLFKVPRNDWSSCGFDVNQGALCPKRWAEDSHWLVCSAVYTQAFANTTDLLKTGYAERMFPIVELQLAKASWRLAGWLNALVDSVYSAEHDSQPDKPEFKQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVA4</accession>
    <name>N1PVA4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_31847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVA4"/>
    <dbReference type="STRING" id="675120.N1PVA4"/>
    <dbReference type="eggNOG" id="ENOG502SF5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_606939_0_0_1"/>
    <dbReference type="OMA" id="RHRARWI"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50628" checksum="AAD40DC6A64324A2" modified="2013-06-26" version="1">MANMQRTSDTADVETSPQELSSYQSPSHGSHHALAVHQSRRLRVDDPWYDEQDTLDLPHDDMSRMPTMVTRVNDTTTNEPATPSWCDPEYLRHRARWIRDILDPQVARDGADALHSDEALTLDELLRRLLDHDMSLADIRFTRMHLAISEISGKATRWPKKLIDRCEAIKVVWEAKYGPLKTLGTPLYEPRGRLHDICRPEDLNKEKLLVKWLGSPAARLSPSVSRKVGDLGFVPGDWWISPMFAYRAGIIDSGNPAGGIVADGGGAYAIVLTDSDEVAGSDSNHFRYRARDGDPGRYRLTAATPESRQPIRILRSHTLHSFLKPRAGIRYDGLHTVTGWTVKQDAKTSQTVVTVSFMRLSSEVNMDAVLCRPWSDEVEDYTEYKRLRREHHDKKDGRPPSIIASDGANGHVWSIMLDAAVHPTMGGPTARSPDEERCRLQRGTLGSAMVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVE5</accession>
    <name>N1PVE5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF4149 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_69315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVE5"/>
    <dbReference type="eggNOG" id="ENOG502SF5R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1320942_0_0_1"/>
    <dbReference type="OMA" id="SLPMVRW"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME47342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23370" checksum="95CC16FB3B51985E" modified="2013-06-26" version="1">MAVVTQAIQTLSVSISLLAAGGIAGLSLFDVPELQSQPAARALPQIRWLFSRGSHIFPQAAIASALGFAYLAYDALPSNLRSLSQLLKTTNGLKVNGFLAAALLAFSIGPYTQRIMLGNNFALIKKNEDLGGSRSVNSAAEKQRQGVKAGQYSAEDSVNSKQPQNELRDLSGPMEKTEKDSSEFDDKEVKERLATFGQQNMVRAVLLGAGGIVGLFAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW15</accession>
    <name>N1PW15_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 12 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_60008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW15"/>
    <dbReference type="STRING" id="675120.N1PW15"/>
    <dbReference type="eggNOG" id="ENOG502S675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051064_0_1_1"/>
    <dbReference type="OMA" id="NLWGQAQ"/>
    <dbReference type="OrthoDB" id="95118at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109379" evidence="3">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME47572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="252" mass="26094" checksum="F0BB46FBC9DEB012" modified="2013-06-26" version="1">MKLSVALASALAALAIASPTPILKRAENCEQYGSVQTGDYTVYNDLWGEAQATSGSQCFSIAGLSGGVLSWATTWSWKGGSSVKSYANAALKSLTTSPKQLSSISSIESKWSWTNKGSDVVADVAYDLFTSSSAGGDEEFEIMIWLAALGGAGPISSAYGADGKPTAIATTTIAGTNWSLYKGPNGQMTVYSFVASSAVNDFSGDLGDFFDYLVAKQGFSSSQYLISAGAGTEAFSGSEVTFTTSAYIFAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWE9</accession>
    <name>N1PWE9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWE9"/>
    <dbReference type="eggNOG" id="ENOG502S6ST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_588089_0_0_1"/>
    <dbReference type="OMA" id="RALKPMT"/>
    <dbReference type="OrthoDB" id="5431149at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="494" mass="52635" checksum="E4F4CADDC7EC0C25" modified="2013-06-26" version="1">MASLSPQIDPFTMAFYATASIAGCTRMASAAITTCLATTALTTQSIFGLAVIASAIEIFAIFTLLASACVFLGRVSRGLLLAAWIPAACSCVVATVLSLITLATTIHLSHRDRLAGNEHTSARELAEGGLAVGVVALIPQTVYLVLIWPRAKQRTRVRTEHSEQYQPPVRTVSRRSLSVHLASLPPASPKFFRSIAEPTSPSYSASSLTPRSSFRDSAQRALKPMTSRTRLILHPSLASRDSRDSGSVVQPAGIPNASRGNDEFGSWDTSAVDDSCDSPFASQSKLTRLETIPGSRPVSPAYPLDGPFAGNADSEETALPESLPQSPVLGSETASLRTFSRNTMRRPSNNDQSHIHPLFRTESPVPPPVASPGTVITASVYAGQVVSSEVAPRLLYSSHGSRPASPIPSLLSRARSRTGSIKSFRAGPTSPIEPPERSFSQLADAWPPIPTTPSRPGSIKSFQTGPTSPMPLRIEPTERSLSQLARSHTPQLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWK9</accession>
    <name>N1PWK9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TATA-binding protein interacting (TIP20) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_69750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PWK9"/>
    <dbReference type="eggNOG" id="KOG1824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007157_0_0_1"/>
    <dbReference type="OMA" id="AYIPHFQ"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1128"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME47921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1316" mass="142468" checksum="35F64E95FAE83B9A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXA3</accession>
    <name>N1PXA3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">EEF1-gamma domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_69132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXA3"/>
    <dbReference type="STRING" id="675120.N1PXA3"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_3_0_1"/>
    <dbReference type="OMA" id="TQYFSWT"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="87"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="6">
        <location>
            <begin position="254"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME47050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="47666" checksum="33F2F57ADE13709A" modified="2013-06-26" version="1">MAFGKLYSYEGNPRTTAILAVAKANNIDLEIVHTEPAKGVSDDYKKLNKLGKVPTFQGQDGYVLTEAMAIAIYLTSQNEKTTLLGKTKQDYASILRWMSFANTELLPGLGGWFRPLIGRDPYNKKSLEDHKKQTQANIKVLEDHLLVNTYLVGERLTLADLFTAAIIGRGYQYFFDKAWRAENPTVTRWFETVANQDIYKAVAGELKFIEKAIPETPPKKEKEEKPKAEQPKKQEKKKEVAEEEEDEPVEKPKAKHPLEALPKATFVLDDWKRKYSNEETREVALPWFWENVKFDEYSIYRVDYKYNDELTMTFMTSNLIGGFFARLEASRKYLFGAASVFGQTNDSVVRGAFVIRGQDALPAFDVAPDYESYEFSKLDPTKKEDQEFVNDMWAWDKPIEVNGKPYEWADGKVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXN3</accession>
    <name>N1PXN3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME46984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXN3"/>
    <dbReference type="HOGENOM" id="CLU_794585_0_0_1"/>
    <dbReference type="OMA" id="EYSGFQN"/>
    <dbReference type="OrthoDB" id="10431271at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="349" mass="38341" checksum="C9EC061FA316387E" modified="2013-06-26" version="1">MPFRLAGVVEGIAEYGAYAVIGLMLAVGAVPLLVVISSFSIAGVSLAVLYILYRVTIFMISETFLALRHRIWDPRRWPPSSKIDRQAYRRRQSLRSSEHSIPSRHYAKPRSRRQSHSRMDSVTGTTFATSESATPSRSATIASFASNEDRDFGDLGGWAGPNEDNEALYMARHNQAFSGLLLGCTESPTQQTPIHSRRGSLDSSPIASRSSSRAPITSEYSGFQNQMRPRRTSNEQTSPRKINTPYGPQTPNREGFFDFGGDGSTSFSAGGSITPTSHESRSTLSLNDRQSRSRRSSFYRRSANLSTTSLGQVPEGRPVGGESTLVGSPLTDEDGLRAMRRHVRSATVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXR8</accession>
    <name>N1PXR8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nitric-oxide synthase (NADPH)</fullName>
            <ecNumber evidence="3">1.14.13.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_77571</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOS family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="3"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXR8"/>
    <dbReference type="STRING" id="675120.N1PXR8"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_16_1_1"/>
    <dbReference type="OMA" id="CRHIRYA"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF1">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="11">
        <location>
            <begin position="588"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME47190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1111" mass="122585" checksum="3AA509B8BC6E7D5E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY01</accession>
    <name>N1PY01_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY01"/>
    <dbReference type="HOGENOM" id="CLU_2320335_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="99" mass="11366" checksum="266FD792935F0EAF" modified="2013-06-26" version="1">MFQPPGTFSLTCQRNSSRKQLYICCPPHYFKKADTSRLVGTQIYRSCRSPSGPRRDCWFVTRPTVNLPFSKWSNSKEYRLNITGETTSEASYDEVASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY04</accession>
    <name>N1PY04_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">gpd2</name>
        <name evidence="14" type="ORF">DOTSEDRAFT_60391</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY04"/>
    <dbReference type="STRING" id="675120.N1PY04"/>
    <dbReference type="eggNOG" id="KOG0657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_3_1"/>
    <dbReference type="OMA" id="YGYTCNM"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME48312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="338" mass="36389" checksum="7965A04FE1BB6CEF" modified="2013-06-26" version="1">MVTKVGINGFGRIGRIVFRNAVEHDDVHVVAVNDPFIEPHYAAYMLKYDTTHGLFKGTIEVDGKDLTVNGKKVRFYTERDPASIPWSETGADYVVESTGVFTTTEKAQAHLKGGAKKVVISAPSADAPMFVMGVNNKEYKSDIPVISNASCTTNCLAPLAKVIHDKFTLVEGLMTTIHSYTATQKTVDGPSGKDWRGGRTAAQNIIPSSTGAAKAVGKVIPDLNGKLTGMSMRVPTANVSVVDLTCRIEKGASYDEIIAALKEASKGELKGILDVTDDEIVSSDMNGNQHSSIVDVKAGISLNNNFVKLVSWYDNEWGYSRRVLDLLAYIAKVDAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYF9</accession>
    <name>N1PYF9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c oxidase assembly-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cox11</name>
        <name evidence="7" type="ORF">DOTSEDRAFT_67557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYF9"/>
    <dbReference type="STRING" id="675120.N1PYF9"/>
    <dbReference type="eggNOG" id="KOG2540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045000_1_0_1"/>
    <dbReference type="OMA" id="NKLECFC"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME48551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="262" mass="29563" checksum="DE64AAD0656B7088" modified="2013-06-26" version="1">MAPPGYQSLLEVATRRSQWMCSSCTQTNRSMRWRKQFSRSLQTSPKAREGSAPTMAQMRKPFEEKNKNTLYYAISIILGTVALSYGSVPLYKTICQQTGWGGQPIKSAAHAGPETEDDVAAKLTPVTSSRRLRITFAGSTSDILPWKFTPQQREVRVLPGETALAFYTATNQSKDEDIIGVATYSVTPAQVAPYFSKIQCFCFEEQRLNKGETVDMPVFFYIDPDFLKDPTMRNIDTITLNYTFFKARYDKDGHLAPVPMPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYI2</accession>
    <name>N1PYI2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_67574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYI2"/>
    <dbReference type="eggNOG" id="ENOG502RW0R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_758591_0_0_1"/>
    <dbReference type="OMA" id="ACTCLTI"/>
    <dbReference type="OrthoDB" id="3898846at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="399" mass="43260" checksum="0D425E83B1B5C62F" modified="2013-06-26" version="1">MMPPRDDASSTDDNSFAPGPGKHPPLVIVSERGRHSEASRRIVRAQAARASAAQSRETRARNREDRHRESPQSTNESASIPPLQIPPNANPNTHAQTVRHPKSPQSHSHTQEQGPSRDDGQQESSGNPLKPLMDWILNVLHLSAASFAAGAVMIAGTGIPQLGNASRVLSSAGGMLSDNGEAMESVDITGGIFNRRLPVALPRGFVALQGRIQISDPFLVLLSRTACIDFGSPGAETRLHELLFDIVMTSATTSMANTDRPGHPIQNHLRIACTCLTIFQGQRADGQAFAFDQRYNTGLEAAWAEVIVLDQDVLKEPKSAEAALWAIFVISVTCGSTMTFYHQLLGGLMQDLQLQYWEQVRNVLIDFIYPGSFLDAPCKQFYDSLKSVQAGQSGASVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYK9</accession>
    <name>N1PYK9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 55 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYK9"/>
    <dbReference type="STRING" id="675120.N1PYK9"/>
    <dbReference type="eggNOG" id="ENOG502QV54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002540_2_1_1"/>
    <dbReference type="OMA" id="AVFMNWN"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109439" evidence="1">
        <location>
            <begin position="22"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="420"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="797" mass="85915" checksum="EFAA17B24BB776EA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYL9</accession>
    <name>N1PYL9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_69869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYL9"/>
    <dbReference type="STRING" id="675120.N1PYL9"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="OMA" id="MPRAWIK"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME48073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="486" mass="53919" checksum="1125735A14DCFF88" modified="2013-06-26" version="1">MSRERTLNVGLIGAGLGGLAAAIAIARAGCNVTVLEAASELGEIGAGIQMTPNVSRLLIKWGIDHIVGDDLVQCKEIRIRRKDGKVVQRTELVPKTVREFGFPWWVVRRDHLHFGLAEGARRHGVKIVVGARVSDIEYDQSPVKVLTEKGEHYEFDLVVGSDGVKSVVRKALFPEVTPRAPTNNAAYRTVMPYDLIYEKVPEAREALGNSIDVWSMEKGYVIMYPISGGREWNAVMSHHRAEPVKGVEDDVDLAEMRDLYKDCDPLLKKIMDIVPETKRWPLLITGPLETWSSPNKNAVLMGDAAHSMVNHMAQGAATSMEDGAFLGRILGEVVHNVISLEEAIEIYEKFRMPRAWIKQQASFVLGGVNMTEYEPRGRARDESSAASVQDTSAMGEVRNLQSKPKITGPDANARSWNLWGAPETIQSIFAYDAEADADFAVLNHLQQKSPWDKETGLSHGLEEKWTGWYLPEDQVGRIAKSRGTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZF6</accession>
    <name>N1PZF6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_60029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZF6"/>
    <dbReference type="STRING" id="675120.N1PZF6"/>
    <dbReference type="eggNOG" id="ENOG502QPU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018249_0_0_1"/>
    <dbReference type="OMA" id="GWIWDSV"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="61003" checksum="4D652E501C52EB17" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZI9</accession>
    <name>N1PZI9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_167188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZI9"/>
    <dbReference type="STRING" id="675120.N1PZI9"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035836_0_0_1"/>
    <dbReference type="OMA" id="FRTQWDE"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000004">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME47810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="442" mass="51154" checksum="CF8096BF023B8CAA" modified="2013-06-26" version="1">MALERSVRPLARCLRCARHERISLPIRTLSSSAAQYDAEVQQSTRPTLDPFNVTTPKQERRLMRDQNKMPVGSRRRRAAMLSSPNIPFVELPYQCFQEARNILQEDRHEKLEQIRVMRERIARLSDNVVVDETEQAKKEHQLRSMRHHLEELKILADINDPIVKKKFEDGQADMSKPIYRYLADKDWRSYKRTVLMQRIDQMTVTPDVLPKIDPTVETILSFPAPGSTYRRRLVQHGDFVDSRISETAPQLQVRKFDKGEKLYTIAVINSDVPNVEKDGFDYRCHFLACNVPVSPTNGVIRLGSLDQNTQVVLPWLPAYAQKGAPYQRLSIWLLEQPPAEEVAAGSGEVAPSKVIDLPGAKSQSERQVKANKKHYTRENFILRSLVDAYRLVPVGVDLFRTQWDEGTAEVMRRAGIVGWDVEFKRKRIEPLPYKRLKEERYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZL0</accession>
    <name>N1PZL0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_21577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZL0"/>
    <dbReference type="STRING" id="675120.N1PZL0"/>
    <dbReference type="eggNOG" id="ENOG502RHRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_789945_0_0_1"/>
    <dbReference type="OMA" id="FTCKHNV"/>
    <dbReference type="OrthoDB" id="3946271at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME47835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="351" mass="38528" checksum="CF180C89ADA8CFBF" modified="2013-06-26" version="1">MAKNNGNPSMQAMQAATTGYYSATKHLSCPFEGCDQRFTCKHNVNQHVREAHTGERPYECHICAEKGDFTAFSRPASLYRHQRGVHNYEPNIRPRGRPRGLHGPRAKKSVGRNDAPISATPVNDKVKANNHNDYTTHQRLQEACQKAVQNADPSTQPCWLCPIVLPAGQEALLLHGHMAHDDPFQMKCACSICTASFAQEIAATCSSQDRSNRSNQPLSTRQAPLVQQPKPMRTLDIDFLSTLDKRLMRVKATRISNDDIMSGVASGSNSETDATDPDDMVGLVSSDISKTPPIQTGGGQSRADSAIGSGHAFEQGDINDYAKPLDLSESLEDFLRNITDDYSSADEHMCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZW6</accession>
    <name>N1PZW6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_21511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZW6"/>
    <dbReference type="STRING" id="675120.N1PZW6"/>
    <dbReference type="eggNOG" id="KOG3445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117700_1_1_1"/>
    <dbReference type="OMA" id="ISKWIDL"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000173">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME47764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="138" mass="15650" checksum="57B4449557C00D26" modified="2013-06-26" version="1">MPLQALRTVAKPQNGVGAFILQCKRLDFHYCDWAGSSKGMNAFLKYQLQTFAKENPSIEVTVSPRSGKHPVIKGHYINGRIKPVCVRNMTPNEIMRKAELLKEANGEKLKRVTKPVKSLNESVRGIWSPFHAKEQYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q002</accession>
    <name>N1Q002_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">MIND kinetochore complex component Nnf1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_120425</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q002"/>
    <dbReference type="STRING" id="675120.N1Q002"/>
    <dbReference type="eggNOG" id="ENOG502S9JT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064565_1_0_1"/>
    <dbReference type="OMA" id="IHLAHLM"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF3">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="142"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME48578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24164" checksum="F6D94791282A1B50" modified="2013-06-26" version="1">MDLDTDNRSPSPPLNPPIPSAPGPRATALQKLYNDAISHILKTCSYTNFSSCFPTPSCTVPGSLKLLHEQFTSKLGASMHKEFTSILEERNVIPSLNELDHLIEDAKRRKTQASESQSPTTSKPPHTLPAKQLYISHLAPTLGRYEQEMKARQEVLAEENHELAARVLQQRRDIQALMEGLEGVVRDLNGSVEALSKEDVEGLREKNREVDEVMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q085</accession>
    <name>N1Q085_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_122714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q085"/>
    <dbReference type="STRING" id="675120.N1Q085"/>
    <dbReference type="eggNOG" id="KOG2742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_19_0_1"/>
    <dbReference type="OMA" id="HADSHFD"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="140"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME48055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41724" checksum="7471013889184CD1" modified="2013-06-26" version="1">MAPIKVGLIGYGSSVKVFHLPFILPNPDLDVYAFLQRAEAPRDKSNVASGKHCTVDHPNAKHYRTAKDFFGDAGIELVIVCTGHDSHAELAEQALQTGKHVVVEKPFTITSAEADNLIALAAKQNKILTCYQNRRYDSDFRTVENYIKQGVFGRITEFANHYDVDNPSWIHSAREPGPGDGLLYGLGSHSIDQTLQLFGLPKSVTAFSRTLLTRSDDSFTIILQYDGEHKDLISTIKTTVVAPIEQAFALKYWVRGTKGVFIKVRKSAIASIEQLIDHGLSSPGIGTGIEPERFHGYLTTREDIDLKFEKPSSDTGVKFDGKVPSKQGSYLDYYRDVVAAVRGEKEVAVKPEESRNVIRLIELANESVEKGVTIAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q099</accession>
    <name>N1Q099_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_68053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q099"/>
    <dbReference type="STRING" id="675120.N1Q099"/>
    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022453_4_0_1"/>
    <dbReference type="OMA" id="GQCTYHP"/>
    <dbReference type="OrthoDB" id="3996471at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF112">
        <property type="entry name" value="RNA EXONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="434"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="652"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="688" mass="75743" checksum="F5F085CBD87EE486" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0D5</accession>
    <name>N1Q0D5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_67996</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0D5"/>
    <dbReference type="STRING" id="675120.N1Q0D5"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_449745_0_0_1"/>
    <dbReference type="OMA" id="GQECISK"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF11">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G06590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="239"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="310"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME49117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="55603" checksum="FC6CFBE089FB783F" modified="2013-06-26" version="1">MPGGKGSKQPEWKLRAHGLYSMNWRRIILDEGHQVRNPKTKGSMAVCSLFSRSRWVLTGTPIVNSLADLYSLLRFVGVSGGLDRLEMFNRVLVRPIKNGDESATSLLKAIMKAFTLRRRKDMKFIDLKLPKLEEFVHRIDFTEKEKERYDALFLQAKGMMKTYSDKRNSGAEGASSAYQHLLEILLRMRQCCNHWLLCAERVTNLLTQLETQKTVSLTPENKKALQDVLQVQIESQEDCPICLDSLHHPVISVCGHSFGQECISKVIEQQHKCPMCRAELPDETVLVGPANGCGDESATDDLDLTQSSSKLEALVRILEATKGNGNKTVVFSQWTRCLDNVQSRLDNEKSYKYCRLDGTMSASERDEALQSLEQDKDTTVMLASLGVCAVGLNLTAANSVILCDTWWAPAIEDQAVDRVHRLGQTRETRVFRLVMDGSIEEDTLAVQADKRKLMMVAFSEKSNKRDGARSGRLADIQRLLSREVNGDDVQKASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0G4</accession>
    <name>N1Q0G4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_68042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1Q0G4"/>
    <dbReference type="eggNOG" id="ENOG502S52Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_243448_0_0_1"/>
    <dbReference type="OMA" id="GQLKQWA"/>
    <dbReference type="OrthoDB" id="3918840at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mediator complex subunit 15 KIX" evidence="5">
        <location>
            <begin position="56"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="457"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="597"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="774"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="877"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1146"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1352"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1488"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1567"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="199"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="511"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="617"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="899"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="926"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="976"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1190"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1212"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1236"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1375"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1390"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1504"/>
            <end position="1518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1614" mass="178550" checksum="6DE5F54CD71055D4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0M2</accession>
    <name>N1Q0M2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_119628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0M2"/>
    <dbReference type="STRING" id="675120.N1Q0M2"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021544_1_1_1"/>
    <dbReference type="OMA" id="QLHGSIN"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099115">
        <property type="term" value="C:chromosome, subtelomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140765">
        <property type="term" value="F:histone H3K56 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009299">
        <property type="term" value="P:mRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046459">
        <property type="term" value="P:short-chain fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="68"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="389" mass="43353" checksum="01EDA313425BC0FF" modified="2013-06-26" version="1" fragment="single">MLYPTRADSAPWPSPPASQNTSHRGSPATDGMASGTDVDKDGPPPAKRRRVSKERTTEYLDLRKDTVDPEQQPQLDRLLNVLHKRQKIVVIAGAGISVSAGIPDFRSAQGIFRSLKEEYNLKGSGKELFDASVYKDDNSTSSFHDMVSTMSRLTKDAKPTAFHHMLATIAQEDRLLRLYSQNVDGIDTSLKPLKTRVPLAKSQDDGKWPRTVQLHGGLDKMVCSKCHELADLDPELFTGPTAPLCPRCEEINDIRTNHEGKRSHGIGRLRPRMVLYNEHNPDDEAIGAVTKEDLRKRPDAVVVVGTTLKVPGVRRIVREMCATVRDRRGGVAIWINNDPPPTGKDLEDCWDIIIRGPSDKVAKRAAMRKWDDPVLSESFLEVSEEDARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0P1</accession>
    <name>N1Q0P1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_143030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0P1"/>
    <dbReference type="STRING" id="675120.N1Q0P1"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038964_1_0_1"/>
    <dbReference type="OMA" id="FRKEVCH"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF294">
        <property type="entry name" value="POTENTIAL PROTEIN LYSINE METHYLTRANSFERASE SET6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="11"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="352" mass="39333" checksum="9C958314B5821AED" modified="2013-06-26" version="1">MSLSLSLPVSEQFAVRDIVNAGRGVIATRNIAAGTLILESGPPAFHVIFKTYAKETCAFCFAWDRGRTLPVRDNVTAKVFCTSECQAEWLKEQGKPGVESWLSLAAYVRSKKRGTNADEIMSDGPKPDLNDMDAAWREAEKRAKTLQKLRTATTSQITKSDWKSAQAVIQKMDEDIDVNMLSYTLSGALYRHRHSSKWQSEVLALAMDDRPHKTQHDLDISCNSYVQLTSVIALELLPSLTPELCRTMTMADNHNAFGIRAGGEDCEEYMGYGVYPSSSYFNHSCSPNVNKRRVGRSWEFSAARDIAAGEECCITYLGGDEKDLDRRARQSRLHEVWGFHCYCNLCTAKAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1J8</accession>
    <name>N1Q1J8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1J8"/>
    <dbReference type="STRING" id="675120.N1Q1J8"/>
    <dbReference type="eggNOG" id="ENOG502RM7G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1570612_0_0_1"/>
    <dbReference type="OMA" id="TEVYHER"/>
    <dbReference type="OrthoDB" id="5403747at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="170" mass="17924" checksum="0E0871313F0F3E15" modified="2013-06-26" version="1">MSTAANKTDTAFTARDFQMLAKAMGCMKGEIAVDYSKFAEVGGYKNANSAKASWHSLKKKLDKASEGTVSFAGEPDTAGVPASPKSKKRKSASNDEQGEEDDTIDTAPLAKSTKKGRKPKASSAAANTKAEAQAVARIKKPDEEMGENGGAVKDEAEGEDEDAFQAKIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1N2</accession>
    <name>N1Q1N2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_20053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1N2"/>
    <dbReference type="STRING" id="675120.N1Q1N2"/>
    <dbReference type="eggNOG" id="ENOG502RXB8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033570_0_0_1"/>
    <dbReference type="OMA" id="ADSGKMC"/>
    <dbReference type="OrthoDB" id="4657524at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="2">
        <location>
            <begin position="64"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="1">
        <location>
            <begin position="174"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="324" mass="34031" checksum="3CA23C96E88ED0E6" modified="2013-06-26" version="1">MKSAVLLLPAAAHAFVTQNTGTGCCFHVTAEGGPGGQVDQLFDGQNRIGQTGLPEGQYCINANGGLTDSNGRGCILTPPTGQWQCDAGATPTPGFSVGSDGKLAVNGSTSFYGAPTGDNGGWNIYDKPLMDEPKTTPVTLFVDNCQATKQPPPAPAPPSSACPAELPSKISDFEFPHLIVPVDSKHPDQSFGTSYNGTAEGSISSIFNFDIPASTKGNTCGLKFFFPEQKDLETSAFEYSGDGQFQFAVLSSPATESTTYASAPKVQQDFGYFTLAPGTAQDIANVDCPAGERIGIWLKPVGNSKLNFFQDYNPCPIGLYIVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1V3</accession>
    <name>N1Q1V3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1V3"/>
    <dbReference type="STRING" id="675120.N1Q1V3"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009958_6_1_1"/>
    <dbReference type="OMA" id="IYKHTME"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="70464" checksum="32050355893E2ABF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q277</accession>
    <name>N1Q277_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_68208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q277"/>
    <dbReference type="STRING" id="675120.N1Q277"/>
    <dbReference type="eggNOG" id="ENOG502SH5J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006524_0_2_1"/>
    <dbReference type="OMA" id="HFFYCRI"/>
    <dbReference type="OrthoDB" id="3365636at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="609" mass="67454" checksum="AB074F74FDBB0F1D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2G5</accession>
    <name>N1Q2G5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_109763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2G5"/>
    <dbReference type="STRING" id="675120.N1Q2G5"/>
    <dbReference type="eggNOG" id="KOG1592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_1_0_1"/>
    <dbReference type="OMA" id="VCLDRWG"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04701">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF43">
        <property type="entry name" value="ASPARAGINASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="252"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="319"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="223"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME49438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="426" mass="46398" checksum="3CCC916193FA23A7" modified="2013-06-26" version="1" fragment="single">VTPRIIIHGGAGNITTENMPPKSYKAYKDALLSILSHANHELSKSKATALDIATYAVSLLELDPLFNAGRGAVYNTAGRHELEASVMVSNGHRKRGVGVMKVRRTKHPIRLAREMLIRGEQEDGGGALGHCQLEGETCERLAREWGLEEVRPSWFWTRRRWDEHRRGLGLSHADRDYEDERKKADEEEGCAGEEVREVHDVVENDRLSIANSQWDGKEYLPQGTVGAVVLDKTGTLCVATSTGGLTNKLPGRIGDTPTLGAGFWAEQWYEAAVQPSMPTMSMSEGIFSSCLPNFSSYQRVPHTDDRQESELRAVAMSGTGNGDSFLRVNAVRTAAAIARYASGFSTSAQSSTGQIPLQKAVTAVAGPGGQLQRSAEDRWQTGGEGEGGIIGIDLLGGKGKIVYDFNCGGMFRAWVDDEGKGRFELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2Z9</accession>
    <name>N1Q2Z9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <title>The Genomes of the Fungal Plant Pathogens Cladosporium fulvum and Dothistroma septosporum Reveal Adaptation to Different Hosts and Lifestyles but also Signatures of Common Ancestry.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Okmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H.A."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">NZE10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2Z9"/>
    <dbReference type="eggNOG" id="ENOG502SWY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120062_2_0_1"/>
    <dbReference type="OMA" id="PAIGMQD"/>
    <dbReference type="OrthoDB" id="3945172at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="130" mass="14018" checksum="A5AD1A82B772D3A7" modified="2013-06-26" version="1">MAQSSPSEVLSFVRTIRAGQTLKTRTISRASARPFSSSIRPLYPETDRPKSDVGGPGKDSKHALDKDNSSVQDVQTSNSHAARSARAQDTGGAATQQKDPKNQEAQKTKDAFPERPDNIGMQDERGGKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3I2</accession>
    <name>N1Q3I2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3I2"/>
    <dbReference type="STRING" id="675120.N1Q3I2"/>
    <dbReference type="eggNOG" id="ENOG502QPHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025891_1_0_1"/>
    <dbReference type="OMA" id="GPSMIHH"/>
    <dbReference type="OrthoDB" id="5352132at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="56617" checksum="D88893F64F8304A5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3I9</accession>
    <name>N1Q3I9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_31429</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3I9"/>
    <dbReference type="STRING" id="675120.N1Q3I9"/>
    <dbReference type="eggNOG" id="KOG2979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028753_0_0_1"/>
    <dbReference type="OMA" id="TWFSHLE"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="12">
        <location>
            <begin position="304"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="104"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="163"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="389"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME50361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="477" mass="53370" checksum="D110D91ADDA05010" modified="2013-06-26" version="1">MASRSRQSTARPTPTPSRAGRQSTVQPTPRGGGDTSNIEPPLYEAPQFPINPQGQRALAALSRTHDLSKLEKRLKDAQAMLTESAMEINDRLKEKDDRLKKIRDKHQPGDEENDAFFAQQEQSLATLREKTESMTTRMEGQMRKTVDCREMLQFMKESVEAAHNDARNHASTQASTQPARTQGRRRTEGEDDEEEIDSDEDEEIPDFQPTDPGAAAATQAGRPPVEVFREQVDDRKTRWQIKSMSERYAGNEDYVRFRQVVHDAQYPEDTIELAPPEEWFNEDGTVPPPGTTARPRAGADEDDSDEEIAISRANISTKCPLTLKELVEPYSSKKCPHTFEKAAIMEFLAGQRGHCQCPVPGCQQMLSYLDLHTDALIVRKIKRIQRAAQALQEEGSDDEENDDGGGNGTQRNAHVIPSDIDGMAEDEDPFVNVKTQLKPEPRPTGASGMPRSSQAPRNTQVVDLDDSDEEDNQTMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3P9</accession>
    <name>N1Q3P9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_144215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3P9"/>
    <dbReference type="eggNOG" id="ENOG502S5UU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078844_1_0_1"/>
    <dbReference type="OMA" id="GIWNIKD"/>
    <dbReference type="OrthoDB" id="5363135at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="66"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="178" mass="19644" checksum="7111F07895706910" modified="2013-06-26" version="1">MSAEVAEQPSLSKVDSAVDDKAPASPTDSKVKHRRTSSTVTGVFKIEDLEKEGVDIKIAPETQKLNWKVNTSPSTVDDKDVLKKLLTTPPIKKIDLHWPLGLEVTARNLKGVTIKDALDAIHKQYKKKTDDELSDPYLAGFEWDKEECYTRFVVHQKKTGEAPSGGGSKKKKGKGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q438</accession>
    <name>N1Q438_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_163510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q438"/>
    <dbReference type="STRING" id="675120.N1Q438"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="OMA" id="WLGFFKV"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="220"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME49279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="373" mass="41592" checksum="B3259163111F1DA7" modified="2013-06-26" version="1">MAAAAVAPPSTHSEARQAAQDYLNQRLASGAYTKATRPFTVPEINIAKSFSNNTNDKKAVALQIHDACTNSGFFHITGHGISEGTRQTIINAAKRFTKDLPRSKKEALHVKHSKYFRGWEPADHTYVNPSDWSTETAAPETKEGFNWGYEAGLDPTGGDGQYCELDGEKMNGNSWPAEDDLPGFYNDVKEYYGQVLQLARHLFQLFALSLDLPEGYFDEMTTHPGGIARLLYYPPSKDPKPQDPSEPDKEIGLGAHSDYECFTILLCSTASGLEILSPENVWVPAQPVEGSFIINVADFLMRWTNGVYKSTIHRVVNRTTHERYSVPFFFSINYDQTVETLPSCITPEHPSRYQPVKAGEYILERLKATAKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4H8</accession>
    <name>N1Q4H8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_144978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4H8"/>
    <dbReference type="HOGENOM" id="CLU_2427002_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME50253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="91" mass="10157" checksum="010E7B06BA868481" modified="2013-06-26" version="1">MSRVLALQIASSKRRDQAERSETSWALQVSRRVDECLPTNWCTGAQLARMLSLSHIAYRSTTELPIVDACLTGARIFRSSRCGTLGERSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4W6</accession>
    <name>N1Q4W6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7603 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_68690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4W6"/>
    <dbReference type="STRING" id="675120.N1Q4W6"/>
    <dbReference type="eggNOG" id="ENOG502QU2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002590_0_0_1"/>
    <dbReference type="OMA" id="DQKWQCE"/>
    <dbReference type="OrthoDB" id="5395440at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056023">
        <property type="entry name" value="DUF7603"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24554">
        <property type="entry name" value="DUF7603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7603" evidence="3">
        <location>
            <begin position="818"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="823"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="951"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="472"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="862"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="880"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="956"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME49955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1056" mass="117560" checksum="29402EC27BE6D661" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5D3</accession>
    <name>N1Q5D3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5D3"/>
    <dbReference type="STRING" id="675120.N1Q5D3"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_20_1_1"/>
    <dbReference type="OMA" id="MLTFRHG"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="56"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="332" mass="37298" checksum="0A1CAE25EE4005A8" modified="2013-06-26" version="1">MTAEEIQRHPEYPHVHWQLKADSKGKIDVAAGRGGPFRLAYEIHGHGPKKIVWIMGLGGFMKTWQRQTKDFGHTEADKYTCLIFDNRGMGESDKPILRYTTSEMAKDIVELLDHVGWTDARSVHVVGISMGGMISQEIAMQIPERICSLNLISTAPRIVRTLPFMENIRNRINLMVPKSLDDQIAKVKADCYSAEWLAKADETEHVVEPFPSNGDRFAAQEINKRLSPGIFTPRGFLCQLYAAGFHHKSDKQLKQIGDAVGRNRILVFHGTGDHMIDFVHGKMLLEGLGGEASGVTKSFHEGMGHVGPFEIREEFRRLIAERIEKTEALGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJX0</accession>
    <name>M2WJX0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_179713</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJX0"/>
    <dbReference type="STRING" id="675120.M2WJX0"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_8_0_1"/>
    <dbReference type="OMA" id="AGCLEEW"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF14">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY PROTEIN 7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="302" mass="32914" checksum="B76BA5188D3A819C" modified="2013-05-01" version="1">MSQQPGSQLASNGFDFTPTIHSDTYEYIKPEQFDLNGKAVLITGASKGVGLHAALSFARAGASYIAIAARTSMKDLESDLITAAKEAGKQPPQVLALNLDVTSEDSVAAAAKEVETSFGRLDILLNNAGYLERFLKPHEQDPTDWWRVWEVNIKGVYLVTRAFLPLILKSQDSLKTILNVSSIGAHALMSGASGYQMGKLALLRFGEFLNTDYGEQGLLAFGIHPGGVPTELAKGMPDNMHSVLIDSPGLAGDTIVWLTAQRKEWLEGRYVSVTWDMKELEGKREKIESGDLLKVRMDVGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2WKL5</accession>
    <name>M2WKL5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_180103</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WKL5"/>
    <dbReference type="STRING" id="675120.M2WKL5"/>
    <dbReference type="eggNOG" id="KOG3189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065642_0_1_1"/>
    <dbReference type="OMA" id="ISHRVYT"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME39518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="270" mass="30592" checksum="056049C23DACA59C" modified="2013-05-01" version="1">MATVTINTIPPINERPIKNTVVLFDVDGTLSPARLHASSEMLQLLSDLRRKVAIGFVGGSNLVKQQEQLGTSTINVTTLFDYCFAENGLTAYRMGQQLPSNSFIQWIGEEKYKKLVNFCLHYVADLDIPVKRGTFVEFRNGMINVSPVGRNASTQERNDYEKFDLEHKIREKFIAALKKEFPDIGLTYSIGGQISFDVFPTGWDKTYCLQHLEKDKALPDGVDFKSIHFFGDKAFKGGNDYEIYEDSRTVGHSVKNPEDTMQQVKELFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2WMC7</accession>
    <name>M2WMC7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_132769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WMC7"/>
    <dbReference type="STRING" id="675120.M2WMC7"/>
    <dbReference type="eggNOG" id="KOG3712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011526_0_0_1"/>
    <dbReference type="OMA" id="MIWLREN"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000119">
        <property type="entry name" value="DNA damage and replication checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="58"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME43198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="702" mass="77828" checksum="2CF47AFE6DA1008A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2XGF1</accession>
    <name>M2XGF1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_39682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XGF1"/>
    <dbReference type="HOGENOM" id="CLU_1115736_0_0_1"/>
    <dbReference type="OrthoDB" id="10518578at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME38151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="249" mass="28074" checksum="21E63CAB85E9C8E3" modified="2013-05-01" version="1">MAVFMGTRNMGITSSDALQSQIIVLSTTSPLATFLFTIQQCLEMPTPWNTSARTNNHRHVAGHPASALASRPHHPLVQIEPSWRKKMDEVEARIKKEKGNLGVVEGEVQLKDKERVYLEFKLRRLVAEQNKLRKESALEELNKQVSQHVAKIELMKRSNLTYEQHGLEILGEKMANGAMKRKAEAARAEMDAGTCRVKRERFAPTASVKAEPTVLQTDIEPFEESDIEYDEDGDDDDDVDEDDDDGDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2XGV7</accession>
    <name>M2XGV7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_75461</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XGV7"/>
    <dbReference type="STRING" id="675120.M2XGV7"/>
    <dbReference type="eggNOG" id="KOG3991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014832_6_1_1"/>
    <dbReference type="OMA" id="WMKLNPH"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="583"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME38717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="609" mass="67827" checksum="69BDE2C1A455A883" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2XHL5</accession>
    <name>M2XHL5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_83580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XHL5"/>
    <dbReference type="STRING" id="675120.M2XHL5"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009958_6_5_1"/>
    <dbReference type="OMA" id="NENITMF"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF81">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME38937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="671" mass="74052" checksum="5E0E1EA8877569A8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2XI83</accession>
    <name>M2XI83_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_56651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XI83"/>
    <dbReference type="HOGENOM" id="CLU_1731419_0_0_1"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004029474" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17176" checksum="8511469621E68E85" modified="2013-05-01" version="1">MLSRIMLAAILLAMGALAKPLHSKRQSPLDPNDHEFEDEPEIAAFCITQDLTATTEEFTAATEKYCHDMSSKGINIATGDHYTESFDCNGERCITLSLYFKCLDHNNAPTHGLMHRHTCNEYFELPWANGETCWQLHLRLRTRTSTEQSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKN3</accession>
    <name>M2XKN3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">O-methylsterigmatocystin oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_72446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKN3"/>
    <dbReference type="STRING" id="675120.M2XKN3"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OMA" id="WPEVENK"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF8">
        <property type="entry name" value="CYTOCHROME P450 2E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="67916" checksum="B37594D6805D6795" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2XLR4</accession>
    <name>M2XLR4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_72693</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XLR4"/>
    <dbReference type="STRING" id="675120.M2XLR4"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_1_1_1"/>
    <dbReference type="OMA" id="FLDAPMT"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="10">
        <location>
            <begin position="2"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="11">
        <location>
            <begin position="167"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME43367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="323" mass="35176" checksum="6D33F96CF19C347E" modified="2013-05-01" version="1">MVGYIGLGNAGFSMASNLPKAGYSVIVHDVDDAKVQKAVSEWPNTTAANGKPEAFADCEVIVTMLPHGKIVREVLLGKDNFARALKPGTIIVDTSSSSPFDTIALGKELAEHQLKLIDSPITQTYMHATDNGESTLIVGADDEQDFKKAEPIIRTMAGYVFHMGKLGNGHAMKTLNNYIMASSICALADSLVAGQKYGLDPQQMIDVLNVGTGVCFPTLDTFRRDGLTKRYNSGFGLALLVKDLGITEDFMQHNGFHTDLPALTKRYLGDALKEVEPMADHTKALVGWEKRSGVKLKPTEKAEDIPRKDFDHRLQGLNRPSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2XZB6</accession>
    <name>M2XZB6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YjgF-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_39585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XZB6"/>
    <dbReference type="STRING" id="675120.M2XZB6"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_1_1"/>
    <dbReference type="OMA" id="RIWGEWV"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF22">
        <property type="entry name" value="ENDORIBONUCLEASE FAMILY PROTEIN BRT1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14323" checksum="ABC0A63C2F1145B3" modified="2013-05-01" version="1">MPAAERTLVTVLGAPRPNFDAYSLVVRSTGDTIHVAGFMGDDPETGKIVEGGVAAQADQAMKNIETCLKAAGSGVEKIVRRRMYFMNIKQDIKTVMDVWDRHVPKPQPVSTAVQISGLAKEGALIELEVEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIC3</accession>
    <name>M2YIC3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_57076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.M2YIC3"/>
    <dbReference type="eggNOG" id="ENOG502SHV0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_225839_0_0_1"/>
    <dbReference type="OMA" id="AYDNAEH"/>
    <dbReference type="OrthoDB" id="5151921at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1400"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1470"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1519"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1622"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1710"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1787"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1902"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2015"/>
            <end position="2171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2188"/>
            <end position="2312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2365"/>
            <end position="2634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2691"/>
            <end position="2727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2740"/>
            <end position="2881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2894"/>
            <end position="3097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1405"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1485"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1524"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1569"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1798"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1847"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1920"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1970"/>
            <end position="1979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2033"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2069"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2091"/>
            <end position="2105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2188"/>
            <end position="2198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2207"/>
            <end position="2217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2236"/>
            <end position="2250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2251"/>
            <end position="2263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2266"/>
            <end position="2276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2291"/>
            <end position="2300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2392"/>
            <end position="2402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2487"/>
            <end position="2496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2515"/>
            <end position="2524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2608"/>
            <end position="2634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2796"/>
            <end position="2814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2907"/>
            <end position="2918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2967"/>
            <end position="2994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2996"/>
            <end position="3014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3022"/>
            <end position="3035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3044"/>
            <end position="3063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3088"/>
            <end position="3097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="3097" mass="333007" checksum="41D6B772A037997F" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJY4</accession>
    <name>M2YJY4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_83072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJY4"/>
    <dbReference type="HOGENOM" id="CLU_2542550_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="83" mass="9283" checksum="4BC59BB6028BB4BF" modified="2013-05-01" version="1">MAGICRSGRNLPKCDGSAAGLLTSCLPSASSEPRQFEARAPWVRSFFNLGLHHADFKEYSHSGLYSMTMRWRRPDTIMTICDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKS5</accession>
    <name>M2YKS5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_139391</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKS5"/>
    <dbReference type="STRING" id="675120.M2YKS5"/>
    <dbReference type="eggNOG" id="ENOG502S1B1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068297_0_1_1"/>
    <dbReference type="OMA" id="RRWQLGF"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME39571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="234" mass="25922" checksum="A8735EF7CD98E2F1" modified="2013-05-01" version="1">MSSLLYTRTTCLRAATIASNSVLAPALFTAPLITSAQSSKHAQFTLNAQPLNHHFPSTRLGLRYVSTSPATNSEASVPEHILTWNRFFDLRKKRRWINLGCSGITAFTAVSLVTPLLAAQDFDSWGAQISGLDPIIVLGISTFAVAAGGWLCGPSFGSAMFTVWAARRGWNKLIAEKEKSFYARIKRYRADPSASSPQNPIPDYYGEKISSVKDYRRWLKDQKAFNLKKDKAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2YL46</accession>
    <name>M2YL46_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TUG ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_75356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YL46"/>
    <dbReference type="STRING" id="675120.M2YL46"/>
    <dbReference type="eggNOG" id="KOG2699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534160_0_0_1"/>
    <dbReference type="OMA" id="APKYDWG"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16105">
        <property type="entry name" value="Ubl_ASPSCR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17075">
        <property type="entry name" value="UBX1_UBXN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059238">
        <property type="entry name" value="UBX1_UBXN9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TUG ubiquitin-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="508" mass="54929" checksum="5B7C724C2A639525" modified="2013-05-01" version="1">MASQIYVVDSGIKRTTIRVTPGRYMREVLEEACKSRKLVPESYALKTQNNKAVDLSQPFRLSGLSAGAKLQLVQASKSIGVVNVALQLPESEGGGRVADKFPSTTSLWLVLRKYEDGVAGQLSRKLNLTQRAVPSNQVSGAGRLEYEQPVVNVMGRNLDTFADLQKTLGQLGFNSGSVLLRLDFKNSEQPLEEAMKEIGDHFNAPDPSTQQIASVEPIAVLPTQEQATDASDASLAAGNEDDLTMTEASQIGATSPTEAIMPTGTQAQPSSIPEQMTAPPANTLDGISVYRPPSSSTPAAAMQPDDPSIFEPSIAHAKAHQAALERAGKNTRLLSDKELEEQEDARQASIALIQQVTVRVKYPDQSMIETTCYASESGADLYAKVEETLSQAGEPFELRFLGAKGFQTVPNSTTNRLVRDLGFRGRIMVTLVWSSSASAKARQGPSLKDDYRSRAQDLKVELQTQQAAGQENHKAAMAKKDKPEPGSSSKSKLDVESKMKKFLGFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLX7</accession>
    <name>M2YLX7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_80474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLX7"/>
    <dbReference type="HOGENOM" id="CLU_1255970_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="220" mass="24514" checksum="00442953633A945C" modified="2013-05-01" version="1">MSASKQRRRTTMLYSDWSTQRPSHLPIAAAYHRLAADDIHRIHSVSMAVRFSCRARTCFAARHGQQHYHRAAVRGHLEPYAAGNMDSCVTNDSVHAVVASEQLQRQAMRMCVAAASANCISRPTRSRMLPPMHSHDLRDILFAANILCTADHPRSTRSVGPLPGILHATMPANGIQQTMSQHPGLRLDDLTLGSYLMRLSQALDALVLQQTRFQCLPHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2YMQ4</accession>
    <name>M2YMQ4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_72567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YMQ4"/>
    <dbReference type="STRING" id="675120.M2YMQ4"/>
    <dbReference type="eggNOG" id="KOG4444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017002_3_0_1"/>
    <dbReference type="OMA" id="HRGWKDL"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME43220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="65420" checksum="1BCDFA4778D29229" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2YNJ9</accession>
    <name>M2YNJ9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PhoD-like phosphatase metallophosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_80921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YNJ9"/>
    <dbReference type="STRING" id="675120.M2YNJ9"/>
    <dbReference type="eggNOG" id="ENOG502QPM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013967_0_0_1"/>
    <dbReference type="OMA" id="IHGPASF"/>
    <dbReference type="OrthoDB" id="2100241at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="1">
        <location>
            <begin position="315"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="677" mass="75754" checksum="27BE8169FFFE3593" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2YPY6</accession>
    <name>M2YPY6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_72891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YPY6"/>
    <dbReference type="STRING" id="675120.M2YPY6"/>
    <dbReference type="eggNOG" id="ENOG502RIS7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_3_3_1"/>
    <dbReference type="OrthoDB" id="2212170at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF43">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME43686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="168" mass="18478" checksum="6D6ED1A2722BD775" modified="2013-05-01" version="1">MAIESGSVPQEDIKPDNDTVTGSCLCGGITVTVRQQGFFTKPTGHTCHCENCRKMSSSAFMSLLMVRTSDIDISDPKGILKIFRDNDSLSGRTVLRPFCSECGSPTACALQGEPRLSLVALGMFSKMPQPEFELFTAHRQDWVKPVTTEETQYQFADGFVQYAAPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCF8</accession>
    <name>N1PCF8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCF8"/>
    <dbReference type="STRING" id="675120.N1PCF8"/>
    <dbReference type="eggNOG" id="KOG2061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031771_1_1_1"/>
    <dbReference type="OMA" id="MPGPWAD"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="227"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="363" mass="39354" checksum="699DFCE690E66BD0" modified="2013-06-26" version="1">MNLLLQINGDLPDRFLGHERRLYIWACKRKTCRRKDGSLRGFRATRQTKVQQSASTTGSKKPEATHGTTAAAPTKINLGETLFGVKPSSKASANLFTSPSGSGAQSNTFAAAGSQNNPFASASSLAAKPPQKPFNEPTSSLTQSFADKARISTPSQPIPQLTPTPSEPWPSSSSFPEPYHSLHLDADKEYIDPEPVQAPSGVRVDTGGEGSSSSGGLDKEAFESSMDRTFQKFADRLSQNPEQVLRYEFGGQPLLYSRKDAAGKLLAPAQEKKDMKVKVQSSGGSNIPRCGNCRAERVFELQLTPHLISELEAEEMGLDGMDWGTVILAVCSKDCQEPGKGEEEVGYVEEWTGVQWEELAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCR1</accession>
    <name>N1PCR1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_74967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCR1"/>
    <dbReference type="STRING" id="675120.N1PCR1"/>
    <dbReference type="eggNOG" id="KOG1663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050461_0_0_1"/>
    <dbReference type="OMA" id="KWRVHRT"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME40343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="264" mass="29139" checksum="788BCA7433D255A9" modified="2013-06-26" version="1">MSFSSTPVFDASKGYQKKGEGTYFNDGREIELLHFVYNKPNIDEIRDSPAKVVAAIDEYARTKKYLMNVGSDKGKIVCDLITEVKPKTLVELGGYVGYSSILFGAAFRSAGGQRYYTLEHNPEFGAVIGSLVDLAGLSDVVKVVVGDSGASLERMHKSQNLRKIDLLFIDHTQFERDIKLAERLGMISEGAVVAADNCIYPGHPEYWQYMSDSVEKRREFSRVAQSPAEIGNPNLMYDSNLVHSFEPSGEKDAVGISRCTGSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDN2</accession>
    <name>N1PDN2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_158924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDN2"/>
    <dbReference type="STRING" id="675120.N1PDN2"/>
    <dbReference type="eggNOG" id="KOG4842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025898_1_0_1"/>
    <dbReference type="OMA" id="VLPEHLC"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="10"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="495" mass="55181" checksum="716B75A6F5EFBA9C" modified="2013-06-26" version="1">MPLGFERFNERSQRPNPLINFIKPLDTPHKKTSEEFLSRIAAQCYPVMKEHHISVMALEEYEPNPEFLGRNFNAGEVIQLVLKDKQGRWLSMKFVQMVMMHELAHCKQMNHSRFFWGVRNEYAKQMEELWAQKYTGEGVWGRGRGLETGEWLNAAVPDNSLIPEHLCGGSYRRRGKKRKRGRQGGGGEPEKLSYAERQQKRIARKFGKHGVSMEGQSLGDDELLRGALETMNGGKRGAGKPRVANSKRGRELRAAAALARFDQEKSKPLEKTPDLEDDMDSETESEWEGDDERDAVIISDGHGHDLIKVCGEGDDDEDDADKEMDELRMLNAAPKSKTGRKQALASKTARPTKGQAGYEDSETESEGQGDPTSSEADKTQSVPPSHPIEISKDSLPASQAELLLQTQLCPICSLENEPGSSTCIACSNVLRPKLLPNRWRCKSDTCKESTYINAGDVGRCGLCGAQKPKMMSSTSGGSASDRPMGITRPEVLRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDP7</accession>
    <name>N1PDP7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_29390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDP7"/>
    <dbReference type="HOGENOM" id="CLU_994060_0_0_1"/>
    <dbReference type="OMA" id="TATSEIW"/>
    <dbReference type="OrthoDB" id="5314997at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="32979" checksum="C2E6470961D69152" modified="2013-06-26" version="1">MRSPKSNCSFHKKDLSFSHMQHNQLIPTSRISKDKFTATSEIWEMAVSPDLDSAVLDDSRNIFPFFDLPRELRDNIYDHLLITRRRTAEEHYLALKIDNLTDPTASRVSKQFRSEYLARACKHPIITQFIEHVDFYGDICEDTFPAPISRSQIAEFLLLEGSTEGIMHPDWIEELLTRLPKVTEVRVKIATLCSTVQEFEEGYDEEDGWLDIENLACFELYHSSERDYREFDFDKHAKDHLVKKWDFENKRWEYVKDKKLRYVSLSYVVDLANERAQVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEI8</accession>
    <name>N1PEI8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_27170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEI8"/>
    <dbReference type="eggNOG" id="ENOG502RHI2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1019511_0_0_1"/>
    <dbReference type="OMA" id="RMEKIFI"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="273" mass="31149" checksum="A8E301BE4DE0C80A" modified="2013-06-26" version="1">MHTSSRDRTPANVVNGREDELFMSPSSEVKTENADIEDDMRPRRAEKRPAQTISQGSASKRQRTGDRVASGTCNFNPTAGRPAEIIDLEDGEVPNRGPPNAASSSRAQQPAQRNRTVSSQQPRPAPSVDLTSDENVITFQILNKDIQTMTTSKAFSYVKSRMEKIFIRRSRRVLNDNLESTLKVMAHAVSNPKSAKAFILTTYRTTWKKKLQDAVKYRKDQYDKVVRLQDEHDWDADVERYGRDFVKPKLKLYEEAKQDFQIVEELIEVMKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PET3</accession>
    <name>N1PET3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PET3"/>
    <dbReference type="STRING" id="675120.N1PET3"/>
    <dbReference type="eggNOG" id="KOG2308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002680_0_1_1"/>
    <dbReference type="OMA" id="HSSYWIL"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF6">
        <property type="entry name" value="PHOSPHOLIPASE C1020.13C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="684"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="908" mass="100312" checksum="C5061230D92E8043" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEX8</accession>
    <name>N1PEX8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEX8"/>
    <dbReference type="STRING" id="675120.N1PEX8"/>
    <dbReference type="eggNOG" id="ENOG502S739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152700_1_0_1"/>
    <dbReference type="OMA" id="TIDYQMH"/>
    <dbReference type="OrthoDB" id="5561579at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="94" mass="10200" checksum="A5B53E019936149B" modified="2013-06-26" version="1">MVSSIIPPKIASPSAIGGAADAARMQNVVGFYERLPRGAAPAAKPSGLFQRYQARYMGAKPSPMPIVHVVGSLILLGYAQNYYFHLRHHKNNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFC4</accession>
    <name>N1PFC4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_38025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFC4"/>
    <dbReference type="HOGENOM" id="CLU_2145790_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108764" description="Secreted protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12516" checksum="7260A0D0329F20BE" modified="2013-06-26" version="1">MLLLLGAPGFHLSCLLLKLLALLVIGVQWSECGGCCRDLVQEVEEGHSAFRDEQREMSAHWREQLSGASGWRKGKTWIRGRCQHVIVDQGPQLRLFGPPALLAAIDLRPIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFE3</accession>
    <name>N1PFE3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair protein rad9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_176418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the rad9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFE3"/>
    <dbReference type="STRING" id="675120.N1PFE3"/>
    <dbReference type="eggNOG" id="KOG2810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030657_1_0_1"/>
    <dbReference type="OMA" id="NETQCRF"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026584">
        <property type="entry name" value="Rad9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009303">
        <property type="entry name" value="Cell_cycle_RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME41333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="480" mass="53960" checksum="BCBF10C83D6B6C07" modified="2013-06-26" version="1">MATLSFSLTPEATGRVYEQLTCLAKFGDAVSLEARREKLTLTALNSSRTAYASFALDARAFFLNYDFTSNSAGSGGDRFTCRLYNRALQAVFKGRTADARGRETTIDRCDVTLQDQPDNTECRLIVHMVSKHGMTKTYRLIYEAVEVMHALFDKTAATQGWRISSKVLREYIEYFGPKTEQLDMLAQEGERKIVFTSFTEKIQDGKEVLKQPLETAIGLDAREFEDFHMQENVHIVISVKDFRAIVTHAETMKCPISTHFSYPTRPLQFSYENFGIHSEFTLMTTGDYRSASSTPTPKFVSTRSSSRQPSIIPPQSFSRAPSEMLPPARPNAGRPPLGSQSQRSSLREQVRPTVAMGEDPDPDSLFIPNGGWGDEDQTWDPTNYERDEEDEMLGWDASNNDLGASMRSQRPTIRDLKTAPPVRTDRDIHQEQEVGESLDPANMPPTQRLSQVSILLVAFTSSRILLGLLTQTLQLQGMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGD8</accession>
    <name>N1PGD8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_26811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGD8"/>
    <dbReference type="HOGENOM" id="CLU_445503_0_0_1"/>
    <dbReference type="OrthoDB" id="10685503at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="613" mass="68204" checksum="910EF07192FDEC84" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGI4</accession>
    <name>N1PGI4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGI4"/>
    <dbReference type="HOGENOM" id="CLU_2984473_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="58" mass="6487" checksum="63CB2B1B174E3491" modified="2013-06-26" version="1" fragment="single">MTSATVASCSLSAGQEGRWVHNTSAHCQWIESLQRRVRHQRTRSDTAVVPVNQLIRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGP0</accession>
    <name>N1PGP0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_36709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGP0"/>
    <dbReference type="STRING" id="675120.N1PGP0"/>
    <dbReference type="HOGENOM" id="CLU_455622_0_0_1"/>
    <dbReference type="OrthoDB" id="3650858at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="599" mass="67049" checksum="1129327834709958" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH36</accession>
    <name>N1PH36_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_46445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH36"/>
    <dbReference type="STRING" id="675120.N1PH36"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_4_1_1"/>
    <dbReference type="OMA" id="PDFQPFE"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="53"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="251"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME41449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="506" mass="56471" checksum="4B1E86AB530CFC79" modified="2013-06-26" version="1">MSVMIQSIVRVTQPNSYSSPSKRPRVHHVVEKVPEKSMEAYVEEVRRLFEEPLQTEKLLGISKQLQSECRERMLKSDISMLPSYQHTLPSGRERGDFLALDVGGSTFRIALIRLTGKTRLGSDGMQVRRIRQFVIDDETRGLQGQTFFDWMADRVGEMLGEYNHINGTTNARLSMGLAWSFPIEQTSLRSGKLLAMGKGFKATHGVEGQDISELIMRSCNRKGLNVEMRAIVNDGAATLMSQAYRDPSTCMSLILGTGTNAGVYLPVEALGSDKFGERPDSWFEAAKHVLVNTELSMVGKRSLPITRWDDTLNSRHSLPDFQPLEYLITGRYLGEIARLILVEAIDTIHLFGGQMPERLDEPYAFDSRILAEFESDTSVTMDKARAAFLQAHPTRSLLRHNELEFIREIARLVSRRAAAYLATALHALWTVRTESEGLSLGEATHVTVACNGTIVEKYPYYRELCQRRLDELCVLSGATKGAVTLKMAPESSIFGAAVAVACLEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH47</accession>
    <name>N1PH47_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 14">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_81912</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
            <location evidence="1 14">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 14"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PH47"/>
    <dbReference type="eggNOG" id="KOG1057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000914_2_0_1"/>
    <dbReference type="OMA" id="AQIWACS"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="17">
        <location>
            <begin position="268"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="208"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="678"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="866"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1138"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1238"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1568"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1054"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="720"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="755"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="883"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1140"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1239"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1276"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1568"/>
            <end position="1586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME41672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1611" mass="178077" checksum="B5B46502473D105E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHM4</accession>
    <name>N1PHM4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHM4"/>
    <dbReference type="STRING" id="675120.N1PHM4"/>
    <dbReference type="eggNOG" id="KOG3229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069208_0_2_1"/>
    <dbReference type="OMA" id="KILWEVT"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="229" mass="25839" checksum="D80E94942E728D33" modified="2013-06-26" version="1">MDGVRKFFYGPTPEEQRRKCNALVRQNNRKLERDMANLKALESKTRTLILSASKRAQRNPAQKDQALQETRIFARELLRVRKQRSRLATSQATLQSVRMQVDEAFAMRKIGDSIKNSTSIMKDVNMLVKLPELTGTMRELSQELVKAGIIEEMVGDSLPDSQLLEGEDEEAETEVDKVLGEILKDRTSVPGMQLPTEPVGAVEEQPGEEDVDSEEILAQMRGRLEALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIK6</accession>
    <name>N1PIK6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_55052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIK6"/>
    <dbReference type="STRING" id="675120.N1PIK6"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_13_1_1"/>
    <dbReference type="OMA" id="QKDRMVD"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME41141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="33478" checksum="47484A7A092D7C3A" modified="2013-06-26" version="1">MASEPYSLTRDSANPPRNKTILITGGASGIGLATALYLHEPAYKNNIVILDKASSPPLIAQSGLTNSSRFLYCQCDILSWSSQRDAFAQAAQKFDGIDCVFVNAGLAEIGEQIWTDVHDSNGNLAEPTRATIDVDIRAVGDTLKLAMYHLRDDSTSSAKKGSGKGRGGNIVMTASLAGYLASAGAPLYSAAKHGVVGYLRALKGDCAKAGIAISVIAPGITLTNIILGRRDGQSLEDWGRDMASRGVPINDAETVALTVANLMGEGLKANGKGVLIQANKMQELEGGIAKSRAQWMGKEMLELFRGGRNAPLFPNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ00</accession>
    <name>N1PJ00_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ00"/>
    <dbReference type="STRING" id="675120.N1PJ00"/>
    <dbReference type="eggNOG" id="ENOG502RDGT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058675_0_0_1"/>
    <dbReference type="OMA" id="WALYHRS"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="1">
        <location>
            <begin position="5"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="283" mass="30859" checksum="A156C638EC68631F" modified="2013-06-26" version="1">MEPAGLAMGVVGVAALFDGCMSAFNYVESGKSFGKDYQKATLKIEILQLRLSRWGESVTRVDEPSQLPAGVALASEQEHRTVEKLLGEILNELEDAERISSRYEPEPAANGYDSGCESIESLTVRTRELALTRQKKVSFGLKAKWALHHKGKLKNLIDSLDGNVKSLVELFPGAKQKQQQLARQEATALAELAQDKEAVLALKEASQELDPDLDSALYTATSGHSFGTVFTSDTASIFAGNYVAHGYTGPISNAQHRFENVQTSDQAKAFFGNQYGGKHIFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ33</accession>
    <name>N1PJ33_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_93154</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 15"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ33"/>
    <dbReference type="STRING" id="675120.N1PJ33"/>
    <dbReference type="eggNOG" id="KOG4718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045153_0_0_1"/>
    <dbReference type="OMA" id="WPGDKFV"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosomes element 1 RING C4HC3-type" evidence="17">
        <location>
            <begin position="222"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="266"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME41331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="319" mass="35347" checksum="FB471053048DF391" modified="2013-06-26" version="1" fragment="single">YNDTHRAYLQSLLACQTTTYEKSKPILSAILTAHDRPTAVEDITQEDFEAYISTLSDALSPFDLEIRSSLDQRSKVRIYALVNVASDAMTQMATVHTPDEIAFVKRVLDAMFETYNTGRGEVMAITGMQALKCAKVGTGDRREGAGGATQGGKAAELTITQAERTMEAMVEEGWFHLSRNGFYSLSQRGIMELRSWLREMYNEEPADDDEDEEVQHIRIKDCAACREIVTVGQRCPNLACNTRVHNGCSRNFLRIHRDQKCPSCKTEWKDAPPVGEKAARNVPNRGGGGRRSTNGTAASRRSSAGMNGHGDGEEDEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ42</accession>
    <name>N1PJ42_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_73048</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ42"/>
    <dbReference type="STRING" id="675120.N1PJ42"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019264_0_0_1"/>
    <dbReference type="OMA" id="CIWGALR"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME42129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="686" mass="76235" checksum="B75D6D67E3523414" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJL7</accession>
    <name>N1PJL7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_176049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJL7"/>
    <dbReference type="STRING" id="675120.N1PJL7"/>
    <dbReference type="eggNOG" id="ENOG502RYJ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032662_2_0_1"/>
    <dbReference type="OMA" id="VSEHMYW"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="41963" checksum="6982D385B756998E" modified="2013-06-26" version="1">MFERKPPRLHVTADDDEFDSSILQHLKDEGFNVTYLPWQNGGKPYRTQLAHLADDLELGESYAILSYASAAADCLDYHLKPQPHLAALIAYYPTHIPSPKASYPTQLNLLCHIAGSQGFAPAFPSYTYRNARPGFAEADLEEYNKVAASLAWTRTLGFLRKNFKIEKGEELEALRERHSAAVFLRKDVQEVMGSFTGDGWVTCVPTMTGGMNRQELVMFYKDYFIPSSPPSLNLRLVSRTTGIDRIVDEMVISFKHTQEVPWILPGVKATNKVVHVALVSIVTVRGGKLVSEHMYWDQASVLVQVGLLDPNLVPGSFQKQGLKRLPVCGAEAASKVLDEESKPSNELIPDWKNRVKRQGASLPARPKQAVNGGQAGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJU7</accession>
    <name>N1PJU7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_90394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJU7"/>
    <dbReference type="STRING" id="675120.N1PJU7"/>
    <dbReference type="eggNOG" id="KOG2796">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022275_0_0_1"/>
    <dbReference type="OMA" id="QDPQAYH"/>
    <dbReference type="OrthoDB" id="428342at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="354" mass="38835" checksum="716D56555DF770A7" modified="2013-06-26" version="1">MAAALNLGFLQNPDLYHQLLVNDVPKAFLESASQPSLDAPLANLLQGGHFRRGADKALRDLLAHSGDDPTFLLQLLYTRLACLVLISRPDLAAQEALPLLDLMARNPPGVQDIVQIMPWEFRMLLVRLQSIGAADGGRRGIMALYAIAGEVRANLRHARSSSDNDNAALWTGRIHDLGLRVCDALVEMGELETATRHLDTLADVDQEELGYRKALLKVRVGDVTGARQCSDQLQDAARKKGLESLLEVADGDYSSAVRQWNSLTENHADHDSVAQNIAVSLLYTGQIATARDVLEDLATRLSIFPTLLFNLSTVYELCSERAMDRKTTLTQRAAENPPGPGSGGWERSTFEFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK39</accession>
    <name>N1PK39_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK39"/>
    <dbReference type="HOGENOM" id="CLU_2386127_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="94" mass="10465" checksum="417B260690E202F1" modified="2013-06-26" version="1">MKLCHRSCRWRVHARRPALVGLPRSVGHPDIISLPDPEHVEMSGLSSLLSRDIASRGSLYHPSRISYLGSPRWCALRRLLTGQTGGSTSAFTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKK0</accession>
    <name>N1PKK0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_25732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKK0"/>
    <dbReference type="HOGENOM" id="CLU_1835133_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="140" mass="16434" checksum="F5621C53B0C0AFBB" modified="2013-06-26" version="1">METPTLRRHGLSEDAITLADILLFTLKADYGTRASPRQAWRQIFTIQIHMKMLFAVVRERGLKVPLSSGYGYVDFTPMLHRPRSNLGFLYTLREICFWDTTNQEFQLGKLLPPSMKYFPERVTLAMPTVSRWLPKFEWHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL55</accession>
    <name>N1PL55_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_134431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL55"/>
    <dbReference type="STRING" id="675120.N1PL55"/>
    <dbReference type="eggNOG" id="KOG0224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_6_0_1"/>
    <dbReference type="OMA" id="ILCSFPN"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF14">
        <property type="entry name" value="AQUAPORIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME42280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38031" checksum="FCC0A8FE64503C2B" modified="2013-06-26" version="1">MGDVSHMERLHTNDMEIGATEAVQKHFARHVVATKPVSQRKLNFEHSRPRWLRECMAEATGVFFYVFPGIAAVTAFTINKEDAAFGSLFQVGWAFALGIAFAIITCAPTSGGHFNPAVTICFAVWQGFPWKKVPYYIFSQIFGSFVAGLLLMGLYHEQLDAYAAGLRATGVDSMVFNGGPASVLCSFPSKDQTNLGYLFLIEFFVDSYLGIVIWATLDPANPFISPASAPFVIGLAYAAMIWGFADITISTNLARDLGTRIVAAIFYGGEAFSYYNYSWISILVNVPATLFATGYYEFLMRDSLQKISKGAALHEGGEDGLALHLTKTGISLERGIVNATIDQKLAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLU8</accession>
    <name>N1PLU8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_71710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLU8"/>
    <dbReference type="STRING" id="675120.N1PLU8"/>
    <dbReference type="eggNOG" id="ENOG502RHAG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590553_0_0_1"/>
    <dbReference type="OMA" id="HFFCLRT"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME43993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="463" mass="50812" checksum="682A654CAF0AA108" modified="2013-06-26" version="1">MSARLRKGHTKSRSGCGACKRRRVKCDETLPTCSACQRLDLTCQRLEVATSTKTSSFRRFVPVKVPCTPPPRPSVANEAAQVALHFFCLRTLPILRICQPSTLWDNVITSLLQADDSIRDIAVAIGFFQRLQNESQVTAVVQKQALLAYDAALHSLRLSVGADSAKDSTIHTFSCLLMVLLESLRGSHLDLLVHLRSGLRIAATNECTAGLAEVKEKILHLLQRYRVSSALFGLLAARNTTLIELTTQDDYISGSHKSGPHYKQSAASENYAVIGSSVHLWHDLCEATTAAQRDQVCSAIPEIRAHNAELQASRTSYGPSRPEDQPLRGFAEAQQRLTDLALRSASGVSDQDTQRETASFTAVLDILEESLGKLRALHSCNGDDAIPFSAGIGVIGALCLVALQCQSYSIRLRALDLMELCPRREGLWDAKEAHQVFKKSCLHNDQSSNPHRLIGSMHKLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMJ0</accession>
    <name>N1PMJ0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_44792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMJ0"/>
    <dbReference type="HOGENOM" id="CLU_2073090_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="118" mass="13305" checksum="2EA69D8892D6A246" modified="2013-06-26" version="1">MPEIVARLCANLTCDDEDLLDVSRKRDCEYGILECETSGGSADLLADSSRRTVKACRCRPVSLPRSALSVHRQDSHVRFSLRSLTISCVAGPNFVCQKRICRTTAPRCTRQRQDYERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMZ1</accession>
    <name>N1PMZ1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMZ1"/>
    <dbReference type="eggNOG" id="ENOG502TAQ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2263255_0_0_1"/>
    <dbReference type="OMA" id="AVAVNIW"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="103" mass="11678" checksum="91CF4DA8C519D438" modified="2013-06-26" version="1">MATFQIHYGGDENRLDKWHQLCNDCGVRPAPSINKCKSALRAVSVNIWDLIKAREMGELPVRRFGSEAELRVDLRRPGRRFPLSKVKSSVDNKLLCALLVTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN02</accession>
    <name>N1PN02_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_72282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN02"/>
    <dbReference type="STRING" id="675120.N1PN02"/>
    <dbReference type="eggNOG" id="KOG4076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101493_1_0_1"/>
    <dbReference type="OMA" id="RMYGKMP"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905287">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle involved in cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900237">
        <property type="term" value="P:positive regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902472">
        <property type="term" value="P:regulation of mitotic cytokinesis, division site positioning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME44782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="156" mass="16763" checksum="20723327AA5C38F8" modified="2013-06-26" version="1">MALNPHQKNKVDVSSLSEEEQKLFRLYGKLPNKKDLFNKKLTERKYFDSGDYAMSKAGKADTSSLGTGLGREHPTPENIPHLSQVQNAGTPTAEGGPRGSISGVPQLHPTESRGQSGSPVKEGSILQRGMSVDDQETGDIANAMGDSDAKGMPIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNQ4</accession>
    <name>N1PNQ4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_34957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNQ4"/>
    <dbReference type="eggNOG" id="ENOG502RGSP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1129035_0_0_1"/>
    <dbReference type="OrthoDB" id="4469945at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056444">
        <property type="entry name" value="Zn_ribbon_GRF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23549">
        <property type="entry name" value="Zn_ribbon_GRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="6">
        <location>
            <begin position="129"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME44553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="246" mass="26972" checksum="914B9F11010DEE12" modified="2013-06-26" version="1">MTETANMATHEAKKQEGPPKELREVSDVDRIANALETTSLGHVPVPLASSLQVGGEVDGSDASEVKLDSLGEASVGHLPIWVSAAGHSEPVDGYLDSNLTIGRQSINANKRPTNIISPTWSPYLARKTCLCCRKPAEMCTVSMGNENGNRGRPYWVCTNKRCMVTIKSSYENGWVSWADDKGLDDENPAGYCDVASRQDRICKDEGKKGWGFWTCAEGRCDYYSEDRYGIPNKCGVTVNLFVPFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP34</accession>
    <name>N1PP34_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Versicolorin reductase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dothistromin biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_71812</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP34"/>
    <dbReference type="STRING" id="675120.N1PP34"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_0_1"/>
    <dbReference type="OMA" id="DQKSHIE"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME44125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="299" mass="32337" checksum="4AE6F25FB1F067E8" modified="2013-06-26" version="1">MASDDARKHNNQEFQLSNLFNVKDKVALITGGGSGIGLMAVQALAVNGAKVYICGRTEDKLDTVAKTFSQDIAGQIIPIVADVSKKAEVAKLYKEISEKEQHLDILMNNAGISTSTFNTEAGNAEELKKALFDNDNATYEDWDAVYRTNVSQIYFMTTCFLPLLQKASEGKKGWSASVINTSSISGQVKTTQHHPQYNASKAAAIHLTRMLANEIQTNGLTIRVNDIAPGVFPSEMTAGESGANQKSHIPKEQHEGKTPAARPGHDRDMAQSVLFVASNQFLNGQSITVDGGYTLMAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPN0</accession>
    <name>N1PPN0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_170750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <title>The Genomes of the Fungal Plant Pathogens Cladosporium fulvum and Dothistroma septosporum Reveal Adaptation to Different Hosts and Lifestyles but also Signatures of Common Ancestry.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Okmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H.A."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">NZE10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPN0"/>
    <dbReference type="STRING" id="675120.N1PPN0"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025224_1_1_1"/>
    <dbReference type="OMA" id="HRYPGWT"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="447" mass="49350" checksum="27679099B1F9C43E" modified="2013-06-26" version="1">MHTASDLNIHITTCNAGRELIDIDYFASSLYTTLKPGTLPPDLIVLSLQEIAPLGHCFLGGRLLAPYLSHFAEAVTRAVQWAFGKDAGYEHIITRHAGMSGIVVFGRSRVSARTKSIEAAGTGVGMWEMGNKGAVGIRLGLEPTDSEEKDVLITFVAAHLAPMEKAWERRNEDWKNICQTLIFEPVATKDSTQNDTSEEQPLLANEDHDSGPHSIYNPPSHLFIAGDLNYRTSDSQPDPKDFESWPQPMQTNSDPAHYSKLLLKDQLTRELKANKTLHSLSEAPIEFPPTYKYSSRAQALAQRTINARSHNQHNDSTIPTLDLSDIQEQVYLWAKHRIPSWCDRILFLESAKPTVHDYTALPVQPTSDHRPVVLSCSVPDKAVVTLVKAPFAIASDWKTRRDFARRVEVAVGVGGYLAFTGQGRALTAGTLVGIIVGYLALAFMLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPY2</accession>
    <name>N1PPY2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_70892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPY2"/>
    <dbReference type="STRING" id="675120.N1PPY2"/>
    <dbReference type="eggNOG" id="KOG1199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_42_0_1"/>
    <dbReference type="OMA" id="RHIFEND"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME44993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="262" mass="28083" checksum="FD0CF3983DAF523A" modified="2013-06-26" version="1">MQIKDSTFIITGGASGLGLATVEDLYKNGGYTAILDMNPANGEKVIKSLGERAKFFEVDVTESESLEKAINGAVEWAKQNGKPVRGVMPFAGVGLPGKLIDKNLNPIAMEKLDFVIDINLRGVLNTLRLVVPHIAKSDPVNEDGERGVIVMVSSTSAFEGQVGQLSYVATKGAIRSMTLVLARDLAPNGIRALSVAPSLFSTAMSAQMSDKVRKALESTAEFPKRLGHASEFAHMVRTCVENGYLNGECIRIDAATRMPAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ47</accession>
    <name>N1PQ47_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Short-chain dehydrogenase/oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_87848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ47"/>
    <dbReference type="STRING" id="675120.N1PQ47"/>
    <dbReference type="eggNOG" id="KOG1204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_1"/>
    <dbReference type="OMA" id="IAFNSWE"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF11">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME45517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29954" checksum="68F3ACB96750ED33" modified="2013-06-26" version="1">MTFPYKNVLLIGATSGIGARFAQTLIDNDVFVIGVGRRKDRLEAFVQKAGKEKADYRVHDMNDLEDTPAFVSELFKSHPEIDFVFLNSGIQRALDFTSPSNVSLDTFNLELKTNYTAPVYLTQAILPYLASQSRPTALAFTTSQLALITLHSRPNYGASKAALHHFILALREQLRKAGQSTRIVELYPPAVQTELHDSKNQPDLKNGGEIGMPLEDFNQELWEGLKAGKEDVVVGSAKPIWDAIETPRREQDKKFNDVMDEALKDFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQG0</accession>
    <name>N1PQG0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_52842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQG0"/>
    <dbReference type="STRING" id="675120.N1PQG0"/>
    <dbReference type="eggNOG" id="ENOG502TII9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_634631_0_0_1"/>
    <dbReference type="OMA" id="WASTAYQ"/>
    <dbReference type="OrthoDB" id="3649267at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109525" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="45747" checksum="27217870575CF1A8" modified="2013-06-26" version="1">MYSSLLYALLLKAVVGQLNSGVPGTTSEGESNYYTDLCNRTFADANATGIISFNPNVGGTNANVSWASTAYQPANSTFGRNQTELSLWFNTYGVNYTDNFRLGYDMCYFWVSQPTVNTYERGQSDQGQCLETLDQACVNDILGVTDSYSQQLTASITSGSTSNLSTNSLPGVCTSLAAHITQNFPGSCKVFFETNPPITVYGGPPGLGGALTGPQSLLAKSQCRFENDTYSLLWSQIGDATQVNYYLANYFVTPLLTAYFPIADAARPVSLSYSKSFMNCLRANKLNPGSASVPLPPSPAPLDKLTNTTNANSTNGFPNVNNSTSSSDSASRDSDRGGSGLSGGAIAGVVVGVLVVLAIAGGLVAYYAIRKRKSKRGSVAQMDGHNGYGQLEGKDPVEAPAYGSVHEMTTPVQRAELSSGRAPVELPASKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQS0</accession>
    <name>N1PQS0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_23776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQS0"/>
    <dbReference type="eggNOG" id="ENOG502SIUZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030055_0_0_1"/>
    <dbReference type="OMA" id="EDMYKHV"/>
    <dbReference type="OrthoDB" id="3553147at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109529" evidence="3">
        <location>
            <begin position="26"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="539" mass="59545" checksum="A9C27D3A43F09E1A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQX5</accession>
    <name>N1PQX5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQX5"/>
    <dbReference type="HOGENOM" id="CLU_1555221_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="172" mass="19640" checksum="01DB1B3DF71B61F9" modified="2013-06-26" version="1">MRKKMTSHFPPKPRKSAADPANSRSPENDTLQPPKTKKSLETKRKATLPQEYKVADGLKFCGGGRDSGRRQKAPTQVPDPESLAPAINRKVTSTASERSSEERRGIWTVSRLERRFSRLLSSSTRFGVFESRESRGRLQRTMIRMGPMDSIPIWRVLRLRRMSLRMAQRGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR24</accession>
    <name>N1PR24_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_72297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR24"/>
    <dbReference type="STRING" id="675120.N1PR24"/>
    <dbReference type="eggNOG" id="KOG1687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_1_0_1"/>
    <dbReference type="OMA" id="GCGGIEM"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="5">
        <location>
            <begin position="117"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME44810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="242" mass="26626" checksum="CADD47798A92AB89" modified="2013-06-26" version="1">MFALRRQTQALALRANPVMALQPLRTANAAFISSSSNKKADPHAGPTTAVRAVGPSNVKGNPGAPPPMKKVTEGMEVPLASQEGNKGVVQYALTTLDSIANWARQGSLWPMTFGLACCAVEMMHLSTPRYDQDRLGIIFRASPRQSDVMIVAGTLTNKMAPALRQVYDQMPDPRWVISMGSCANGGGYYHYSYSVTRGCDRIVPVDIYVPGCPPTSEALMYGIFQLQKKMRHTKITRMWYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRN9</accession>
    <name>N1PRN9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_23131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRN9"/>
    <dbReference type="eggNOG" id="ENOG502RMFC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1331934_0_0_1"/>
    <dbReference type="OMA" id="KWQSAGK"/>
    <dbReference type="OrthoDB" id="10509072at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="206" mass="24429" checksum="D961D128D526C717" modified="2013-06-26" version="1">MARKHDSDQLYDSDDSSFESPKSRRRRRARSEESPYTERSRVRPGHTRRHSSYASEKTRSKWQSAGKVALGVVFVGIVAETINRWVQKRETESVRREEDRVREKRRQFEKAKAKRRREEDRREKEREEHSSRGHGPEVWEEVTEVRRIGYLPAEDRGRSQSRAPRRLEAPPSREASVDEWEESEDEARTRRGRPDRSRSKSAVDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRR2</accession>
    <name>N1PRR2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_70938</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRR2"/>
    <dbReference type="STRING" id="675120.N1PRR2"/>
    <dbReference type="eggNOG" id="KOG1195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_2_1"/>
    <dbReference type="OMA" id="HHIGDWG"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="12">
        <location>
            <begin position="92"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="624"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="301"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME45065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="752" mass="84947" checksum="353BCBB05A750439" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRS5</accession>
    <name>N1PRS5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRS5"/>
    <dbReference type="HOGENOM" id="CLU_2605999_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="79" mass="8532" checksum="ABF95B7DA9F56DEE" modified="2013-06-26" version="1">MRLAVQKKGARCSGCASGSVGRSVAEVSPLYCLLWSKRGYQVTSWICAEPVIAIRSGHKLGAWPSDMLSASDWHIVLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRY1</accession>
    <name>N1PRY1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tfc12</name>
        <name evidence="10" type="ORF">DOTSEDRAFT_168469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRY1"/>
    <dbReference type="STRING" id="675120.N1PRY1"/>
    <dbReference type="eggNOG" id="ENOG502QR1M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004517_0_0_1"/>
    <dbReference type="OMA" id="HANPQMP"/>
    <dbReference type="OrthoDB" id="5373550at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14723">
        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="759"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="811"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME46127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="964" mass="106433" checksum="9CFCE32158058F69" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS91</accession>
    <name>N1PS91_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_70294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS91"/>
    <dbReference type="STRING" id="675120.N1PS91"/>
    <dbReference type="eggNOG" id="KOG2046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024074_0_0_1"/>
    <dbReference type="OMA" id="HFLHACQ"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21210">
        <property type="entry name" value="CH_SCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="640" mass="71208" checksum="3A52012176B69DC1" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSB0</accession>
    <name>N1PSB0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSB0"/>
    <dbReference type="STRING" id="675120.N1PSB0"/>
    <dbReference type="eggNOG" id="ENOG502S4U2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048444_1_0_1"/>
    <dbReference type="OMA" id="APVTCLW"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="41393" checksum="A090DB70E282A2D7" modified="2013-06-26" version="1">MAGGSTFTWGHALRLDSNKSPFSSPMAGTHKAFHGVQPVSYKRYNIGGILTTLYGLQELPAHPSEIVCFWLLHGRGDTQDSMAYTAASLLGKYNQERNKRGGGDGPKGLVFACFDQRNHGSRMVENENNVSWKQGNPTHGPDMFSTYVGTAHDLSLLITQVEHHLSFKIQEHVCGGLSLGGHATWVVLMKEPRVRAGMVVVGCPDYVRLMTDRAIRSKVPSTMNTDPPGLDFLGSSDFPQSLLAAVEEYDPAGILLSELDVYGKDDHLHTPSEHEVQRLRTTLDKTLAGKKILCLSGGKDRLVPYEQSEVFLSWFKRAIDPENGWAKDTGIEFEDVVDPKAGHEFSKPMIEHAQRWICDYLLKDAGNEVGRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTD0</accession>
    <name>N1PTD0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_86825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTD0"/>
    <dbReference type="STRING" id="675120.N1PTD0"/>
    <dbReference type="eggNOG" id="KOG4473">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038957_0_2_1"/>
    <dbReference type="OMA" id="SRIGWLR"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME46218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="261" mass="28132" checksum="7477F76E8496F833" modified="2013-06-26" version="1">MSVQYYIRSVDCHTIVEEIESTSTTSNSLLKQQSHRGVFVRDSIIGFADGLTVPFALTAGLSSLGSSKVVILGGLAELFAGSISMGLGAYLAAITERKHFQVAAKRQRQKIGKGVNVEEQAIYGIFEQYGVSRAASRGVMDGLRLNEDMWVQFVMDFELKLSNPSVRMAPLEGLVMGASYFLGGLLPMVPYFATRNISHALFASISITAVILVMFGFAKALITGTTHRDAAWSAVQTVTIGALAAAVSYGIVRGMNESRMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTJ7</accession>
    <name>N1PTJ7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTJ7"/>
    <dbReference type="STRING" id="675120.N1PTJ7"/>
    <dbReference type="eggNOG" id="ENOG502SSWS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473285_0_0_1"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="576" mass="62518" checksum="1A58843A7BC6A65E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU15</accession>
    <name>N1PU15_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_105037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU15"/>
    <dbReference type="STRING" id="675120.N1PU15"/>
    <dbReference type="eggNOG" id="ENOG502SUQR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018631_0_0_1"/>
    <dbReference type="OMA" id="IDSYESW"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="530" mass="58330" checksum="08AFDC8D242C296E" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU58</accession>
    <name>N1PU58_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">DOTSEDRAFT_70468</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="31 32" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU58"/>
    <dbReference type="STRING" id="675120.N1PU58"/>
    <dbReference type="eggNOG" id="KOG0139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_0_1"/>
    <dbReference type="OMA" id="DAMFSYC"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="69"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="183"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="290"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="EME46473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="445" mass="48373" checksum="96BB1ECFA5ED28BD" modified="2013-06-26" version="1">MASLARTIRPLARAAASASSRTAANRTASSRWVPAARCLSLTARQRDANESHTVDVEGLTPTPIFHLSEVEQMMKESVEKFANEEILPKVREMDEAEKMDPAIVEKLFEQGLMGVEIPEKYGGSGMNFTAAIVGIEELARVDPSVSVMCDVHNTLVNTAILKYGSEESKKKWLPQLATNTVGSFCLSEPASGSDAFAMKTKAAKTSDGYVINGSKMWITNSMEAGFFIVFANLYPEKGYKGITAFLVGKENPGLKIAKKEKKLGIKASSTCVIDFDDCAVPKGSLLGEEGHGYKYAIGLLNEGRIGIAAQMTGLAMGAFENAAKYVWNDRKQFGSLVGEFQGMQHQLAQAWTEIAAARALVYNASRKKEAGQDFVMDAAMAKLYASNVAGKVSGQAIEWMGGMGFVREGLAEKYWRDSKIGQIYEGTSNIQLTTIAKLLQREYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU67</accession>
    <name>N1PU67_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_32609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU67"/>
    <dbReference type="HOGENOM" id="CLU_1447642_0_0_1"/>
    <dbReference type="OMA" id="ICCRNEN"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109604" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20325" checksum="C1C156F6625F0A6C" modified="2013-06-26" version="1">MHAFQILAVLTVGAGAVAINNGPVGAWEVANNVASVGTSIASTDKASTFHALRDRIGGLVWRDPYTWDQIPMNCTRRGLCCQTDPRNAILMSDPTTGSELCERTGGKKHHQYDDKRMGNHTVTYIGPHGKSPMKLSAKVCTGAMQDLREECPTNFTVGGFRMTFGGVLFKDDWVYSVNMPTDGKTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUS0</accession>
    <name>N1PUS0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUS0"/>
    <dbReference type="HOGENOM" id="CLU_894357_0_0_1"/>
    <dbReference type="OrthoDB" id="3636334at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="311" mass="34938" checksum="507E231A87E77E16" modified="2013-06-26" version="1">MARTKELFHHINEHIYQGKPLLLQRTSFVAEGESVVCERPGCEEALAANVYYLCLGTDSCFCVRCFEMLWNGECTGGLPIEIGTPRKTPRRDSAVMVGIPQLDGTFDRLHIQQPVFMRAMHAQTHDTPAEPSAPLAQSGIMECMHASSDDDAELVRPVGPVCAPERRASFSEAHLEHDDPGTPDTLDSTDSNGEWRYPPTYFQKIHYGIEPGATLSEIDKAVLALWKHVSVEQWRWNGHLARTDARRAFHADETSEDESLRMEALTSYDADEEEVNGLMSLTGLRKKDCQGRDLSVVLKEAVEIQNQRQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV01</accession>
    <name>N1PV01_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_22808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV01"/>
    <dbReference type="HOGENOM" id="CLU_1981561_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="126" mass="13997" checksum="11F8E4AE50E55A00" modified="2013-06-26" version="1">MPQLFALHCNAHCAHGGYFEGMTPPAARNATPGSREKLLQGTLVLVRASHHYAQFLAFNMGRMRDALTRQDFQDELSDRAVAFFAVRKAFTIANTRTRRLVSDVNAHVNLGTDILLDISGSRLNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVK8</accession>
    <name>N1PVK8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_169043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVK8"/>
    <dbReference type="STRING" id="675120.N1PVK8"/>
    <dbReference type="eggNOG" id="KOG2456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_3_1_1"/>
    <dbReference type="OMA" id="DAFSHTR"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME46444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="487" mass="53162" checksum="8A3DB2C99FB63ADB" modified="2013-06-26" version="1">MSKYTSPDNFKESYDTLHATYATFKTKDIRWRKWQLKQLWWLLVDNTDAICKAFATDLGRTEAETRQYDIGGVKADIKLYLDNVDVWSKGNAAEGAGIIFGRFGGAWLRKEPLGVALIIGAWNFPLVTLLAPACAAIAAGNCVMLKPSELSGATATLLAELVPKYMDQSAIRVVTGGAQETGRVLEHKFNHIFYTGGGKVGRIVAMAAAKHLTPTVLELGGQAPAIVTQTANIDLAAKRIVNFKLANAGQICLNVNHVFVDPSVHDKLVDRMQFWMKEWLKDDSSWLASIISEPHYQRVTNLLNKTDGVIAYTGPSDPAKRFVHPSIITDVKTTDSLMSEELFAPFLPVIKADIETAVSTINTGPHPLGLYIFSSSQKEIDSVMDRTASGGVTINDVALHVASPGTPFGGVGESGNGAYHGKFGFDAFSHTRPVVGLPDWMDKMASFRYGKPTIENLSKFDTAQATWKRGETLQDQSSGSKSFLGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVS0</accession>
    <name>N1PVS0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_69419</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVS0"/>
    <dbReference type="STRING" id="675120.N1PVS0"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_4_0_1"/>
    <dbReference type="OMA" id="NYIWLLQ"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME47477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="253" mass="27863" checksum="86035B791900FFCF" modified="2013-06-26" version="1">MHIDSIPMWEGSGNNYAYLVTDDKTKDAVIIDPANPSEVLPHLKKAVDGGINLKSIINTHHHHDHAGGNVEMLKTYPLPIIGGKDCSKVTKTPSHGETFTIGENIKVKALHTPCHTQDSICYLFEDGNDKAVFTGDTLFIGGCGRFFEGTAEEMDAALNKTLGALPHDTKVFPGHEYTKGNVKFGIKVLQSEPVKKLESFATANKQTQGKFTIGDEKQHNVFMRLDDPEVQKFTGKKDRIEVMAALREAKNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW83</accession>
    <name>N1PW83_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW83"/>
    <dbReference type="STRING" id="675120.N1PW83"/>
    <dbReference type="eggNOG" id="ENOG502SII2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_457097_0_0_1"/>
    <dbReference type="OMA" id="QQMYELQ"/>
    <dbReference type="OrthoDB" id="3926760at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110207" evidence="2">
        <location>
            <begin position="21"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="597" mass="64614" checksum="D12F71A13DB3F8BF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWC8</accession>
    <name>N1PWC8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase</fullName>
            <ecNumber evidence="2">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_70620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="2">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="1">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1 2">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="2"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWC8"/>
    <dbReference type="STRING" id="675120.N1PWC8"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1006667_0_0_1"/>
    <dbReference type="OMA" id="VPNTLMH"/>
    <dbReference type="OrthoDB" id="3341590at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="3">
        <location>
            <begin position="2"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME46665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="327" mass="36994" checksum="1ED3817AE91F0DFB" modified="2013-06-26" version="1" fragment="single">MFELLPGYDCPAYADYMDTRYHMRRKSHELPNSICIFEYTADHLLSRHTAQYSITASRNIYLVVRSVSTVGNYDYTIDYMFYMDGTIEVKFRASGYISAAFYRASKTAGEGEYGHRIGEAVSSSVHDHVVNFKADMDVAGQKNDVVRVALEPVTKSYAWDLPQIKERNTMHLVEYPVTQETSLDWSKNGGEFYLIYSSSERNVWGERRGYRITSGTGMGATPHLTVLNSTTLGDSARWADHDVWVLRQKDTEPRSADPLNCLEPDDPIINFNKMADNESLIHNEAESTHDGDLVLYFNLGAHHIPHSGDVPNTLMHTSASSVMFVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWG1</accession>
    <name>N1PWG1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWG1"/>
    <dbReference type="HOGENOM" id="CLU_1917023_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="132" mass="14368" checksum="DE42F584ABCDF373" modified="2013-06-26" version="1">MYDRRQQTLLKQDTLSSIMAECASLASNTHFAGGEALVREAFAAVAVSLEGRVNLMLQNWQTGSSMSSACSQPFVRMGCVMGCPPRTMNPNIVTLFSGMRCANRVDCCRVVVVPVEFSCLGRIFLYSGSNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWI0</accession>
    <name>N1PWI0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_77977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWI0"/>
    <dbReference type="HOGENOM" id="CLU_1896163_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110239" evidence="1">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="134" mass="15198" checksum="B87078800BFE5FBE" modified="2013-06-26" version="1">MRNIAILMAAFVLGLSMALAMNPVADQHLVASVFAACTAWTSNIRLEPNVTLYNEQETQDLKGIYRRNERAVTYDGKASDDSWHCVIHCEQQGFKGHNPTSGMFDIEQLQCEGRSETLRSLYQSRRWAPVVFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWP7</accession>
    <name>N1PWP7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_32310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWP7"/>
    <dbReference type="HOGENOM" id="CLU_1796428_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="144" mass="15905" checksum="6CCCCD7AA67A5D17" modified="2013-06-26" version="1">MGDSERQYADIHLEPSISSSVREGTRTIGTALTQQRFFVDDNEGSSTVISFTWADTQVYSADTAKSTLTVATNTTMLSAGTVFWKGHQFITSNSKCRARASRPRTFDRRKSWSRFGGRARSRSDRCHRSLGSDLASSPGKGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWP8</accession>
    <name>N1PWP8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_42163</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PWP8"/>
    <dbReference type="eggNOG" id="KOG1913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001147_1_0_1"/>
    <dbReference type="OMA" id="YKSPYDL"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000008">
        <property type="entry name" value="Protein transport protein sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="13">
        <location>
            <begin position="931"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="12">
        <location>
            <begin position="1104"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="135"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="453"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="872"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1402"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1701"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1763"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="730"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="837"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1434"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1456"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1488"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1546"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1701"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1818"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1865"/>
            <end position="1878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME47842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1916" mass="202388" checksum="61A51F1ECF92F357" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWY9</accession>
    <name>N1PWY9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_126514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWY9"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_4_1"/>
    <dbReference type="OMA" id="FFGAWQF"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME46925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="517" mass="55244" checksum="E77087F3F5FC7C4B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXY6</accession>
    <name>N1PXY6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXY6"/>
    <dbReference type="HOGENOM" id="CLU_1768004_0_0_1"/>
    <dbReference type="OrthoDB" id="5272396at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="147" mass="17150" checksum="1D7D4C0F26F3EDF5" modified="2013-06-26" version="1">MLRYREGRQQVQHWLSNIVTDRAICKQVSIVCVQYFEQPHRSTAMLVDVKTFQVSNRESWIHPLLGKPLKTLREVEQELDAAKKEIEPATTYHYVPAFLHELVNLMTVPLSKSRLMLCESMANSRLHGYTDFQLRFEVITIIYSNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY80</accession>
    <name>N1PY80_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mif2/CENP-C cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_69770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY80"/>
    <dbReference type="STRING" id="675120.N1PY80"/>
    <dbReference type="eggNOG" id="ENOG502S47H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027966_0_0_1"/>
    <dbReference type="OMA" id="CHGRVQV"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="6">
        <location>
            <begin position="477"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME47948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="575" mass="63692" checksum="C1F553EC99C55FBC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYQ1</accession>
    <name>N1PYQ1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYQ1"/>
    <dbReference type="STRING" id="675120.N1PYQ1"/>
    <dbReference type="HOGENOM" id="CLU_1283225_0_0_1"/>
    <dbReference type="OMA" id="EVDEYAM"/>
    <dbReference type="OrthoDB" id="3004402at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="215" mass="24217" checksum="9222A3395C28C160" modified="2013-06-26" version="1">MDSLSRADSGIVTVSRKTSVHEQERATYMYYAEQDEVARQTDEYVLANWVFAGAAAEIEYVKQKIGHLAFEYFPSAPSERMVLVARLMALLYLIGESLVELDLDDAEDYLGALDAAVKGHWAPDGNVPAVWMLAFTLDEMKGMDYVATEEVWSSSLSHLRALLIKRGRAQHRRDKYRIPASLRLGYSLVDALEPFAMAQCSDDDSFLLNRRANVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZ60</accession>
    <name>N1PZ60_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sphingolipid long chain base-responsive protein PIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_67674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZ60"/>
    <dbReference type="STRING" id="675120.N1PZ60"/>
    <dbReference type="eggNOG" id="ENOG502QQ1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046464_0_2_1"/>
    <dbReference type="OMA" id="NRWLGKG"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME48712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37774" checksum="C2A3FCFBD5B9649E" modified="2013-06-26" version="1">MHRTYSMRQSRAPTASQIQNPPPPSSSTKGGRFFGKANIGHTFRKSVHAGAFGPDLAKKLSQLVKMEKNVMRSMELVGRERMEVAQQLSIWGEGCDDDVSDVTDKLGVLIYEIGELEDQFVDRYDQYRVTIKSIRNIEASVQPSRDRKQKITDQIAQLKYKEPNSPKIVVLEQELVRAEAESLVAEAQLSNITREKLKAAFTYQFDALREHSEKMAIIAGFGKHLLELVDDTPVTPGETRNAYDGYEASKAIIQDCEDALTNWVEQNAAVKSSLSTRARTLSQRRRNNASGVDLSGQDQDRESGLWIPAQQHQGGEYDDEEDASVDARGREEERVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZI1</accession>
    <name>N1PZI1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_167163</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZI1"/>
    <dbReference type="STRING" id="675120.N1PZI1"/>
    <dbReference type="eggNOG" id="KOG1951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002486_0_0_1"/>
    <dbReference type="OMA" id="KLHVPMV"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="66"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="407"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="537"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="598"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1059"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="608"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="632"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1059"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1116"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME47800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1133" mass="129323" checksum="ED85E9795CCB9BB9" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZV1</accession>
    <name>N1PZV1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_21646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZV1"/>
    <dbReference type="eggNOG" id="ENOG502R9MB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_657499_0_0_1"/>
    <dbReference type="OMA" id="EAYCKVF"/>
    <dbReference type="OrthoDB" id="3650348at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="470" mass="52495" checksum="45CD68E6AF784F57" modified="2013-06-26" version="1">MSRVKRPRLSTEPDRISTAAYAASQPLFSTLRNATDSVDAQKASLTTARDVVQQLHVKIDTGEAKRHETYMHHVVSAWEAATEAYCKVFEELCNVTRADDSEGRPQGKRHDEFVKILETARHARDAVKDHAPAKDEDEDAIAAAWEDEFYKGVHVKSKAPPEPLVQSIGKKRRLADAEPLPEAYPHQRVDQSDEDEIVVKHNSALKKAAPSAESDKPPTKMPPQKSLSDETIRYGRLDPSKIIWENGKLKVPFERLSPDERKAWSVIKQRQKRQIRRTKVKTNRAKGPATARDNEELEQHTEANQDDAFLQDNKSNFSVPGPSPTNRHEPSIPAVEYEDVSAEVEARLKAKAEKKAQDKIKKAEKKRKRESKDSFAGVEQEDSETLPKGDADAKDKPVKPAKKKSKTAADSGISVDGTPVDAKGGDVTKADKAPRKIQKRKNGAEEEDGDEIKVAEAPVKQTAKKRTRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0X5</accession>
    <name>N1Q0X5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_19422</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0X5"/>
    <dbReference type="STRING" id="675120.N1Q0X5"/>
    <dbReference type="eggNOG" id="KOG2843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026207_2_0_1"/>
    <dbReference type="OMA" id="FGFGECR"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="14"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="121"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME48928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="420" mass="46747" checksum="C6EDA743C1B1F4B2" modified="2013-06-26" version="1">MATLKLDQLPYTIQNLPYGIVSSEHNTSPRCAVAIGQHAVDLTRWAKRGTITNLQTGDRSFEEIFAQPTLNSFAALPWNTRKAVREQLQTELKDGKVPSSCLLHLRDAKVHLPMQMGGFSDFYTSLDHCKNCSGELSTATIPKNWYYAPSVYNSRVSSVVSTPTDIRRPKNVYFKAGMDTDPEYGPTRKMDFELEMGFFVSKPVPFGDDMPIGDAKNHIFGFVLLNDWSARDHQLFEMRPLGPFHSKGMGTSISNWITPIEALEQFSTSPHLKQDPPPFEHLTWPGSNDGALDIKLQVKLVRGDKEHIISHSNLKYLYWTPYQQLTHHAASGCGMLTGDLIGTGTISGSGTDEQGNMAELGCLYEAERTRTALLPQSSGTYQDGYLEDGDEIILEGWCENDKGEVVLGLGECRGRIIPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1C6</accession>
    <name>N1Q1C6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_60608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1C6"/>
    <dbReference type="STRING" id="675120.N1Q1C6"/>
    <dbReference type="eggNOG" id="KOG3490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138052_2_0_1"/>
    <dbReference type="OMA" id="FDGMIAV"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001208">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001209">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090262">
        <property type="term" value="P:regulation of transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="9">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME48289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="115" mass="12513" checksum="FF757EC7F0F9E243" modified="2013-06-26" version="1">MSGVPRALRACLVCSFVQTQSKFVKSGCPNCEPFLEMRGSTDVVGDCTSETFEGLITVNDTTTSWVARWQRVVGYVPGIYAVQVTGDLGEEYITAAENYGVTYQPRDGSAQDEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1J1</accession>
    <name>N1Q1J1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_141384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1J1"/>
    <dbReference type="STRING" id="675120.N1Q1J1"/>
    <dbReference type="eggNOG" id="ENOG502S97T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076143_0_0_1"/>
    <dbReference type="OMA" id="LHSPIWT"/>
    <dbReference type="OrthoDB" id="60858at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28693" checksum="C496F4568795E11E" modified="2013-06-26" version="1">MVATRNHPRDFDTSPTDTPPRPSPTKRTTRTAKAALSHSEESSSSTWTHTPSNLTLIWLALSLPLVIWDTIYILGRPYTMEGGWLHWPMYVPYELYAVTDYMYGLPALERNDGWPSAQGLSNAIETALYLAYLWMVYAYGEQEPVQGRGAPDRSLMGRLRGLSESRTLEGREAAVACLVCYTTAIFTFGKTVLYWLIEYFSGFDSTGHNTAFNWITLFALPNLPWIFIPGYIAYVQGAEILQGLETAIGVSKKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1Q6</accession>
    <name>N1Q1Q6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_67472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1Q6"/>
    <dbReference type="STRING" id="675120.N1Q1Q6"/>
    <dbReference type="eggNOG" id="ENOG502QVFG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007968_0_0_1"/>
    <dbReference type="OMA" id="SHERNNF"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="79739" checksum="DF55014C2F46EABF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q289</accession>
    <name>N1Q289_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_39901</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q289"/>
    <dbReference type="STRING" id="675120.N1Q289"/>
    <dbReference type="eggNOG" id="KOG0974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002615_1_0_1"/>
    <dbReference type="OMA" id="FWDITSD"/>
    <dbReference type="OrthoDB" id="5594999at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME48579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="790" mass="86596" checksum="37662933F6A62955" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2C3</accession>
    <name>N1Q2C3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_85192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2C3"/>
    <dbReference type="STRING" id="675120.N1Q2C3"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="LFGVQCD"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000398">
        <property type="entry name" value="Probable 2-deoxy-D-gluconate 3-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="13"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="261" mass="27830" checksum="CC4DBB8FF6B40315" modified="2013-06-26" version="1">MGSVQQLFSLEGKTALVTGGTRGIGQAMAVALAEAGADVLLVQRNDSNRETKDAIEKLGRKAQIYTADLADNASMKALTPKVLADGHHIHILLNCGGIQKRHPAHQFPDEDWNEVLQVNLNAVFTLCRDVGAHMLSRDADQYGRRGSIINIGSLLTFQGGINVPAYAASKGGVGQLTKALSNQWADKGITVNGIAPGYIATEMNTALMQDEKRAASILERIPAGRWGSPEDFKGSVVYLASRASAYVSGEILTVDGGWMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2N7</accession>
    <name>N1Q2N7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Versicolorin reductase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Dothistromin biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_68314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2N7"/>
    <dbReference type="STRING" id="675120.N1Q2N7"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="TWHAWQK"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_6G09140)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME49503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="248" mass="26635" checksum="555316AE72850B23" modified="2013-06-26" version="1">MPGKLEGKVAIVTGGGGGFGKGIAKKYLEEGAKVVIADFVEDVGQKTAQELGCEFHRTDVTKRADWESIKKFVDEKFGKLDVVINNAGTTYRNKPTSEVTEEEYDKVFTVNVRAIYLSTQVLVPYLQEKKNGGSFITIASTAGLRPRGGLTWYNASKAAVINASKSMAVEYAPDNIRFNSVCPVVGLGTGLTDFFLGKPENEKVFMTTIPLGRGSTPSDIGNTCAFLGSEEANFLTGIDIPVDGGRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q315</accession>
    <name>N1Q315_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_67818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q315"/>
    <dbReference type="STRING" id="675120.N1Q315"/>
    <dbReference type="eggNOG" id="KOG3026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069491_1_0_1"/>
    <dbReference type="OMA" id="CEAQWTD"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="297" mass="31856" checksum="3248FA55E2E6167D" modified="2013-06-26" version="1">MSVSALQQELATAQDDLDVVKGALDLDPADADALEMKSVLEESLADVKRRLAAAKKAEQNVPPPPPTDDAPKYDMSKHPKFRKVDSDAPPPPLEEHKAVIFNAGDSVMAKYSADKQWYAATILGKTGSSADPVYTVKFTGYAETETKRKHEVRAVENRKRKADAPPAAAAAPPPTPISPKAVQQGAVISAAPSVDPSLVQKREPSKVSDGPTRMAPAPKKLKGNKTLEKAKSSWNDWQKSGPKKPALGAAGKLGKESQFRTPDLPNAKVGFTGSGKPMSKDQVRKKWNYAAGDDQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q348</accession>
    <name>N1Q348_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_142386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q348"/>
    <dbReference type="STRING" id="675120.N1Q348"/>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010840_2_0_1"/>
    <dbReference type="OMA" id="LCNRIRY"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="73"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="205"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME48904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="685" mass="75307" checksum="979D0A0E9346B0C3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3I0</accession>
    <name>N1Q3I0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_68942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3I0"/>
    <dbReference type="STRING" id="675120.N1Q3I0"/>
    <dbReference type="eggNOG" id="ENOG502S1NM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035241_2_0_1"/>
    <dbReference type="OMA" id="LDTDPFG"/>
    <dbReference type="OrthoDB" id="2285533at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF9">
        <property type="entry name" value="MEAB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME50232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="442" mass="48374" checksum="69286A04D3A9D39F" modified="2013-06-26" version="1">MGDSSILDGDMAAPSKVEPAAEGTPSSIESTPEPEAGVEPSQEPAQPQKRKGGRKPIYATSEERKQRNRQAQAAFRERRTEYIKQLEATIKQNEETLASLQRSHRAAADECLMLRYKNSLLERILLEKGIDVQTELQMKTGSPVLGPGFMHPAPSVPPQPQLQRTALQRQQARRSGQSYPPKLAPGQSSQDMNFVITSPHAHPTPSSHASSPSQLSTRSPMTMHQGGMTPPASAVLAQPQAQHLQKFGRSAQQHPNQAFYQSQQQPAGTQRPPRRPTLSNYQGSTSGLSSISAGSQNSMPQSLPAATGGSAGPQAASAFYPSPFQKHFDQLDQEYDTQHSRSMLDETEPEDIDRNHSPELHGTYPPQFEQGQGHQHGAYYEAQSGVQHGQQQPLMQPTSHPNAEDGSYDVDPNDPMLDADPFGLSASMHYPTSYSYDPHGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3P3</accession>
    <name>N1Q3P3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_77021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3P3"/>
    <dbReference type="HOGENOM" id="CLU_1012024_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME49843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="275" mass="30442" checksum="FDD19BB2C20FC800" modified="2013-06-26" version="1">MVVGRPLFGVWTVGVGETREAVAGVEEDEEEEEEELEEDDAIDSRRFWLSASLRPRSIIVALSYMYDRPRYHLCQYLVQHDDIIPPTASIKADIKMAPQMMLLTFSIAAGIATSSAAEHSACLECVIIEVNQCLIPTWSGHLCLQNHRSMHFDLSGSPAQLRQHGRHQGSTIRMQNRHGSTESVESQSITSAMHEQLRASWRCGDTGPQPHTAPVADRAAHKIGLEASAVAVMLDIGFILPPLASEPSSDASAIYPRHFTTRIHYRTIAACTSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q418</accession>
    <name>N1Q418_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pru domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_164870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q418"/>
    <dbReference type="STRING" id="675120.N1Q418"/>
    <dbReference type="eggNOG" id="KOG3037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041798_4_0_1"/>
    <dbReference type="OMA" id="RSPQFMQ"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="7">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME49988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="387" mass="41113" checksum="4443E63F48592FE4" modified="2013-06-26" version="1">MAATPLITFKAGRCELEGRKVKPDPTPGYVYLYSEDDLLHFCWRPRSAPSTEPDMDLIMFPTDGQFFPLVKEQGTDDLNSPTNGRIFVLKFTSSGQRHFFWMQSKTQSKSGELSWFSNRDQRLGQIVDALLQGEDVDVEGEVEDLRRAGGDAGPDGDADAMEVDGGPSLERREPGGAGQDATGGDPREEGSASREGGADGGRASSSSAPQDTNAIVQNFLNSLNGGKHGGGQPQQVEKPFTTLPDLLPSTTTTAYIAKASPQQIDHLCTLLPPELLLLAQESASSSMAAETNPATAQAAIETLSQSQKKDILNRVLRSPQLQQSLGSLTVALRDGGLPMIGEALGLKVENGGLIRGGSMPLGGGDAVEAFVKGVKKTAAEEENSARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4E2</accession>
    <name>N1Q4E2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginyl-tRNA--protein transferase 1</fullName>
            <shortName evidence="5">Arginyltransferase 1</shortName>
            <shortName evidence="5">R-transferase 1</shortName>
            <ecNumber evidence="5">2.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginine-tRNA--protein transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_143846</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNA(Arg) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83562"/>
            <dbReference type="EC" id="2.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="5"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4E2"/>
    <dbReference type="STRING" id="675120.N1Q4E2"/>
    <dbReference type="eggNOG" id="KOG1193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020349_0_0_1"/>
    <dbReference type="OMA" id="KMQYKND"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="8">
        <location>
            <begin position="114"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME49655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="382" mass="44371" checksum="2229B68DF51467EC" modified="2013-06-26" version="1">MDRGWRRSGTLIYLPDASRSCCPHYTIRLPASEFKPSRDQRQALHRWNRHVLGERYIKEAEKNFPKTKEEKKRSKDSFDLEHTLHESERINLKPGIEPDHRFEVTLEPDKFTEEKFELFDNYQRHVHHEQDEDVSASGFRRFLCSSPVSRQTDDDGKKLGSFHQCYRLDGRLIAMAVLDLLPHAVSGVYFIYHSDFEKWSFGKLSALREACLALEQEYQYYYMGYYIHSCKKMRYKGDYKQQYVLDYDSLQWDPLDDEMRHLMENSQYASMSRHRTTQNGGGSLPDEKDDVLHPTPTDAMSSGLSLLQLGMPGVLSLEQLRRRVELDNMKVHLGRGSVHRIQNISTWESGSDLDHSSLRGIFAELAAVLGPDVAKEAIIDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4Y8</accession>
    <name>N1Q4Y8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_68587</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4Y8"/>
    <dbReference type="STRING" id="675120.N1Q4Y8"/>
    <dbReference type="eggNOG" id="ENOG502QPMQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039097_1_0_1"/>
    <dbReference type="OMA" id="RNWMIFF"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="203"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME49839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="438" mass="49713" checksum="3B88EA2EAF47CBCC" modified="2013-06-26" version="1">MMGLPRLRLPSRNWMIFWSVIGSFAGAVVYDKWQTKRMREKWCNMVAHIAKEPLDTKTAPRKVTIYLEAPPGDGLRSAREHFHTYIKPVLVSAALDWDVVEGRKEGDVRHKTAERIRKKRRRNGEGTPASEDEQEAYTVELIREKNGNLDYPGVGGDIVIGRHTWKEYIRGVHEGYLGPPDMPKLLEEWETPGWDETKADSAQAAAGDAAAVVEAAAQATTPSELTSDSQPVDASLAGAEIPNAVLTEETEEDKKKQEDAKKKKEEDKPKRRFPPSYILPEEYETASLSPSTPDFIGPSVSVRLPHLLGFRNTPIRMYRFLTRRHTQDDIGRQVASAILASHRPYGTVTANDETSASDGSVEVKEQQRVLDFEERDWWKTVRQPRKEHEEDIWLRPMVLDERVASRMRSFQLTAEDEDRAKRIESGAEKVVTEDEGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4Z0</accession>
    <name>N1Q4Z0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_164596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4Z0"/>
    <dbReference type="eggNOG" id="ENOG502QZI3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036934_1_1_1"/>
    <dbReference type="OMA" id="TKVRCYG"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME49844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43500" checksum="AF1023596EE28D3C" modified="2013-06-26" version="1">MSTYSTEPHAMPHGLQQGDPDVGHGPSSASSDKASPLSNLNFFKSLNPEKKQTKDGQPPKRRGPKPDSKPALTRRQELNRQAQRTHRERKELYIKALEQEVLRLKEVFAETNREKNEVLAENRRLKELLAQHGISYDFGTSPIKFSRENSRYGPSSSGSISGSYQIGSDSTGFSPPPPAMSAHAQNMAAVQANQMRSMAQLPSNRLDYDSIGIDFVLTLERPCMDHMQYLMVRSHNQKGQTIHHPMENPDDAEHEHMSGHALMQTAPPYSHLKEKPADIYPHQMPVGIDNGALTKLMQLSSRLPLDREGEITPVMAWSMIYGHERVGQLEARDIELVKQNLAAKVRCYGFGAVVEEFEVHDALDTLFAEKDSTAVPALGHAMAAQQIKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q542</accession>
    <name>N1Q542_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_164873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q542"/>
    <dbReference type="STRING" id="675120.N1Q542"/>
    <dbReference type="eggNOG" id="KOG1110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042860_3_2_1"/>
    <dbReference type="OMA" id="PGGSYCM"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="26"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="137" mass="15353" checksum="7E528FF54ED1CCB1" modified="2013-06-26" version="1">MQSSTMAGKFEPKHKVDLDPPKDDIISLDHLSKCDGKHEGFPTYVAIKGTIFDVTGNKAYGPEGSYKVFAGRDASRALAQSSLKDEECRSDWYDLSPEHKKVLNDWYTFFSKRYNIKGKVEGAQNTGEDLADAEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q578</accession>
    <name>N1Q578_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_68940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q578"/>
    <dbReference type="STRING" id="675120.N1Q578"/>
    <dbReference type="eggNOG" id="KOG3000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041744_2_1_1"/>
    <dbReference type="OMA" id="WIKRFWD"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055028">
        <property type="term" value="C:cortical microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061673">
        <property type="term" value="C:mitotic spindle astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099609">
        <property type="term" value="F:microtubule lateral binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030989">
        <property type="term" value="P:dynein-driven meiotic oscillatory nuclear movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035372">
        <property type="term" value="P:protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1430:FF:000005">
        <property type="entry name" value="Eb1, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="12">
        <location>
            <begin position="153"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME50230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="244" mass="27244" checksum="A998E2F74930C6F8" modified="2013-06-26" version="1">MAESRQELLAWLNGLLSLNFTKVEQCGTGAALCQIYDSIFLDVPMGRVKFNVSAEYAYLENFKILSNTFRKHHVDRPIPVEQLVKCKMQDNLEFLQWTKKYWDQYYPGGDYDAVGRRKGQGAAPLPPTSSRTSTGAGVARRPVGGAVAPRANSRQAGGPATAALQQKNAELVETVQGLERERDFYFSKLRDIELLIQQAMEADPSLEEDEGSLLKQIQTILYSTEEGFEIPEGAEEAALEEETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2WIS1</accession>
    <name>M2WIS1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_75545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WIS1"/>
    <dbReference type="STRING" id="675120.M2WIS1"/>
    <dbReference type="eggNOG" id="KOG1498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033860_2_0_1"/>
    <dbReference type="OMA" id="AENEMFK"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="271"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME38858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="498" mass="57290" checksum="5188F6A5897C08D8" modified="2013-05-01" version="1">MSGDGSIIKADRDYTKECDAAIPEAEKIAENGQTQQAVDKLLSLEKQTRQSSDLPSTSRLLVAIVTISKKAGDWSLLNEQVQLLSKKHGQLKQAITKMVQVVMGFLDDTPSLETKLSVIETLRTVTEGKIFVEVERARITRNLSNIKHQQKDVTAAKDILCELQVETFGSMSRREKTEFILDQVSLCIEDGDWTQAGILSRKISTRYFSRKPKKTAEELEKARKEKEERERMRSDGTIGDEEPEDDDPTDLKLRYYEQQITLAKHDDKYLDACKHYRQVLDTEAVEEDASKLSAALARVIYFVLLAPYDNEQSDLLHRIAQDTRISTHTPREGQLLKLFTVPELMRWPSVESNYGEHLTSTDIFDLKENKKDPKAHQRWLDFRKRVIEHNVRVIAKYYTRVHFSRLTQLLDLSESETEKYISDLVTSKTIYARIDRPAQIVTFEKKRDADEVLNEWSSNMKQLLGLLERIDHLITKEEMMARIQPVAEKQSSKVSAKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-02-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2WIS5</accession>
    <name>EPOA_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative epoxide hydrolase</fullName>
            <ecNumber evidence="7">3.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Dothistromin biosynthesis protein epoA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">epoA</name>
        <name type="ORF">DOTSEDRAFT_57187</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Appl. Environ. Microbiol." volume="68" first="2885" last="2892">
            <title>Dothistroma pini, a forest pathogen, contains homologs of aflatoxin biosynthetic pathway genes.</title>
            <authorList>
                <person name="Bradshaw R.E."/>
                <person name="Bhatnagar D."/>
                <person name="Ganley R.J."/>
                <person name="Gillman C.J."/>
                <person name="Monahan B.J."/>
                <person name="Seconi J.M."/>
            </authorList>
            <dbReference type="PubMed" id="12039746"/>
            <dbReference type="DOI" id="10.1128/AEM.68.6.2885-2892.2002"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Mycopathologia" volume="161" first="283" last="294">
            <title>A polyketide synthase gene required for biosynthesis of the aflatoxin-like toxin, dothistromin.</title>
            <authorList>
                <person name="Bradshaw R.E."/>
                <person name="Jin H."/>
                <person name="Morgan B.S."/>
                <person name="Schwelm A."/>
                <person name="Teddy O.R."/>
                <person name="Young C.A."/>
                <person name="Zhang S."/>
            </authorList>
            <dbReference type="PubMed" id="16649078"/>
            <dbReference type="DOI" id="10.1007/s11046-006-0240-5"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Fungal Genet. Biol." volume="44" first="1342" last="1354">
            <title>A fragmented aflatoxin-like gene cluster in the forest pathogen Dothistroma septosporum.</title>
            <authorList>
                <person name="Zhang S."/>
                <person name="Schwelm A."/>
                <person name="Jin H."/>
                <person name="Collins L.J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="17683963"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2007.06.005"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2010" name="Toxins" volume="2" first="2680" last="2698">
            <title>Genetics of dothistromin biosynthesis of Dothistroma septosporum: an update.</title>
            <authorList>
                <person name="Schwelm A."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="22069571"/>
            <dbReference type="DOI" id="10.3390/toxins2112680"/>
        </citation>
        <scope>REVIEW ON FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2013" name="Fungal Genet. Biol." volume="51" first="12" last="20">
            <title>Dothistromin genes at multiple separate loci are regulated by AflR.</title>
            <authorList>
                <person name="Chettri P."/>
                <person name="Ehrlich K.C."/>
                <person name="Cary J.W."/>
                <person name="Collemare J."/>
                <person name="Cox M.P."/>
                <person name="Griffiths S.A."/>
                <person name="Olson M.A."/>
                <person name="de Wit P.J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23207690"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.11.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2013" name="New Phytol." volume="198" first="525" last="535">
            <title>Fragmentation of an aflatoxin-like gene cluster in a forest pathogen.</title>
            <authorList>
                <person name="Bradshaw R.E."/>
                <person name="Slot J.C."/>
                <person name="Moore G.G."/>
                <person name="Chettri P."/>
                <person name="de Wit P.J."/>
                <person name="Ehrlich K.C."/>
                <person name="Ganley A.R."/>
                <person name="Olson M.A."/>
                <person name="Rokas A."/>
                <person name="Carbone I."/>
                <person name="Cox M.P."/>
            </authorList>
            <dbReference type="PubMed" id="23448391"/>
            <dbReference type="DOI" id="10.1111/nph.12161"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2 3 5 7 8 9">Putative epoxide hydrolase; part of the fragmented gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B (PubMed:12039746, PubMed:17683963, PubMed:22069571, PubMed:23207690, PubMed:23448391). The first step of the pathway is the conversion of acetate to norsolorinic acid (NOR) and requires the fatty acid synthase subunits hexA and hexB, as well as the polyketide synthase pksA (PubMed:16649078, PubMed:23207690). PksA combines a hexanoyl starter unit and 7 malonyl-CoA extender units to synthesize the precursor NOR (By similarity). The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by the fungal fatty acid synthase hexA/hexB (By similarity). The second step is the conversion of NOR to averantin (AVN) and requires the norsolorinic acid ketoreductase nor1, which catalyzes the dehydration of norsolorinic acid to form (1'S)-averantin (PubMed:23207690). The cytochrome P450 monooxygenase avnA then catalyzes the hydroxylation of AVN to 5'hydroxyaverantin (HAVN) (PubMed:23207690). The next step is performed by adhA that transforms HAVN to averufin (AVF) (PubMed:23207690). Averufin might then be converted to hydroxyversicolorone by cypX and avfA (PubMed:23207690). Hydroxyversicolorone is further converted versiconal hemiacetal acetate (VHA) by moxY (PubMed:23207690). VHA is then the substrate for the versiconal hemiacetal acetate esterase est1 to yield versiconal (VAL) (PubMed:23207690). Versicolorin B synthase vbsA then converts VAL to versicolorin B (VERB) by closing the bisfuran ring (PubMed:16649078, PubMed:23207690). Then, the activity of the versicolorin B desaturase verB leads to versicolorin A (VERA) (PubMed:23207690). DotB, a predicted chloroperoxidase, may perform epoxidation of the A-ring of VERA (PubMed:23207690). Alternatively, a cytochrome P450, such as cypX or avnA could catalyze this step (PubMed:23207690). It is also possible that another, uncharacterized, cytochrome P450 enzyme is responsible for this step (PubMed:23207690). Opening of the epoxide could potentially be achieved by the epoxide hydrolase epoA (PubMed:23207690). However, epoA does not seem to be required for DOTH biosynthesis, but other epoxide hydrolases may have the ability to complement this hydrolysis (PubMed:23207690). Alternatively, opening of the epoxide ring could be achieved non-enzymatically (PubMed:23207690). The next step is the deoxygenation of ring A to yield the 5,8-dihydroxyanthraquinone which is most likely catalyzed by the NADPH dehydrogenase encoded by ver1 (PubMed:23207690). The last stages of DOTH biosynthesis are proposed to involve hydroxylation of the bisfuran (PubMed:23207690). OrdB and norB might have oxidative roles here (PubMed:23207690). An alternative possibility is that cytochrome P450 monoogenases such as avnA and cypX might perform these steps in addition to previously proposed steps (PubMed:23207690).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 8">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WIS5"/>
    <dbReference type="SMR" id="M2WIS5"/>
    <dbReference type="STRING" id="675120.M2WIS5"/>
    <dbReference type="ESTHER" id="mycpj-q30dw8">
        <property type="family name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EME38863">
        <property type="protein sequence ID" value="EME38863"/>
        <property type="gene ID" value="DOTSEDRAFT_57187"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_0_0_1"/>
    <dbReference type="OMA" id="WVELMGR"/>
    <dbReference type="OrthoDB" id="3627131at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000443468" description="Putative epoxide hydrolase">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q12437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="12039746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16649078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="17683963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="22069571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="17683963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="23207690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="23448391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME38863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="420" mass="46739" checksum="3F99B3A66B3AD926" modified="2013-05-01" version="1">MEGYTTLPSTATLKPSPFTVSISESKLQTLQDLIRLSPIGPADYNNSSPSTGSKYGIRRDWLINAKKQWEDNFSWRTFEKKLKKYPQYTVPVKGESGETIEIHFIALFSQRQDARPLAFYHGWPSSPFDFLPILDLLTNKYTPETLPYHIIVPSLPGFCFSGSPPIDLDYDMPQAAYLLNNLMIGLGLDGYIAQGGDLGSGISREQAAGCEACKGFHLNMILLPPPANMKELTLEEVEKKAMPNALAFRQSGMAYALEHGTRGGTIGLALQASPVALLCWIGEKMMAWSDSSSQPSLEQILETVSLYWLTDSITRGLYPYRRFASGNEPKINFIEKPLGYSFFPNTYLPCPVSWAKTTANLVQYRRHESGGHFAPWERPRELLEDVEEYVDVAFGKKDSPMMGPKAVEDVSGSGSHARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2WIW3</accession>
    <name>M2WIW3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_180893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WIW3"/>
    <dbReference type="STRING" id="675120.M2WIW3"/>
    <dbReference type="eggNOG" id="ENOG502TKVH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_2_0_1"/>
    <dbReference type="OMA" id="AQAICAC"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME38908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="436" mass="49341" checksum="D3DA2B74C7D995CF" modified="2013-05-01" version="1">MDENGESIANGAHSLRNSPQANVAEKRPLSNGSSTSTPARGAKKPRAPHTKSRQGCLRCKRRRVKCNEEQPKCRACQIRGEDCRYPEKVACSTCLRIECVCFDNALPPVQHADESSVDFEFIYHYGRFTYDTVFLEPINEHAKPLFTPPDCLQYPFLMDLYMALAATHLATLNPAEASRYTVHAIRYQNRAFGRFSGTLVDPKVEDCLPMFLFSAMLGILQLALSRIPQPADHLTPPIETLLELRRLWKGSRSILQHSKNMMPPDAYASIFDNDEDEPRRSHIRAPPTNSDLQGECWLPLKDLLNLVETTFPSPTPTSFSITPDDVDNPDISDDDACKIAIAYLRRVTAVHLSHRPALLLAWPVIIADKFLHLVHEEHPRAQAICACYGFLLRRLNDRWWARGFGQDLILQLASTSNRDVYKEFYGRIFESAMSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJ08</accession>
    <name>M2WJ08_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Family A G protein-coupled receptor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_75607</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJ08"/>
    <dbReference type="eggNOG" id="ENOG502QQVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054785_2_1_1"/>
    <dbReference type="OMA" id="MPWPTIL"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018229">
        <property type="entry name" value="Rhodopsin_retinal_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00950">
        <property type="entry name" value="BACTERIAL_OPSIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00327">
        <property type="entry name" value="BACTERIAL_OPSIN_RET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME38958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34502" checksum="79D59C333A88F4C3" modified="2013-05-01" version="1">MSFILEKRASNNALNVNGAIVNGATADVALTTHGSDWYWAVCAVMTCSAFAFMGLAYTKPRRDRIFHYITAGVVMVAAIAYFTMASHLGWTPIVIEFQRSNPVVRGQTREIYYVRYIDWVITTPLLLMDLLLTAAMPWPTILWAILVDEVMIITGLVGALVASSYKWGYFVFGCVAMFWIIYILVWEARIHANAISTDAGRAFVICGSLTAFMWTLYPIAWGLSEGGNVISSDGEAAFYGVLDLIAKPVFGALLIWGHRNISPADLGLAIHDYGADEPIFHEKNHRNGNGPLADHSGATRPINSANGTNGVTETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJQ1</accession>
    <name>M2WJQ1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_75061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJQ1"/>
    <dbReference type="STRING" id="675120.M2WJQ1"/>
    <dbReference type="eggNOG" id="KOG1590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099502_3_0_1"/>
    <dbReference type="OMA" id="CHIVNES"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:7770001">
        <property type="term" value="C:mitochondrial pyruvate carrier complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050833">
        <property type="term" value="F:pyruvate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME39193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="159" mass="17517" checksum="EF5FB5691B57E1D9" modified="2013-05-01" version="1">MAAAIKALNAKIRSNPVTDYFCSTHFWGPASNFGIPIAAVMDTQKDPEIISGRMTAALCGYSAVFMRYSFAVTPKNYLLFGCHFVNFTAQSTQAYRFINWWYMGGRETALETRAKEGLGMVEEKAEGVAGQVQDLAERAQDKASGLAKEVKGQVEKVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2WKN6</accession>
    <name>M2WKN6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">60S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_75263</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WKN6"/>
    <dbReference type="STRING" id="675120.M2WKN6"/>
    <dbReference type="eggNOG" id="KOG0397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_1"/>
    <dbReference type="OMA" id="NPMKELK"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="7">
        <location>
            <begin position="27"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="8">
        <location>
            <begin position="84"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME39538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21922" checksum="78AFFCF730409ABF" modified="2013-05-01" version="1">MARGENSSQQADGQNVRTQGGKDKSANPMRELRIQKLVLNISVGESGDRLTRAAKVLEQLSGQTPVYSKARYTVRTFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYELRKRNFSKTGNFGFGISEHIDLGIKYDPAIGIYGMDFYCCMTRPGERVAKRRRCKSRIGASHRIDQQETIKWYKNRFEGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2XHP7</accession>
    <name>M2XHP7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_29160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XHP7"/>
    <dbReference type="STRING" id="675120.M2XHP7"/>
    <dbReference type="HOGENOM" id="CLU_789943_0_0_1"/>
    <dbReference type="OrthoDB" id="3649437at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004029251" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="35910" checksum="A6BE566B97F4A5DB" modified="2013-05-01" version="1">MASAVGLMMLVSTAIAAPLTCPASNETQVLGPNGNTFIVECGIDHEADDIANTQVSSFKQCIDACDDPQCVDVSLSGVAFYLKGTLGRAIGASDVQGARKLVTTLAVTTTTTALSSSSSAATAATSVVPCPNNGTEFVANSYARFVTYKGYQGAGSSVGMRRGVGNSTSCVQLCDRAASCAAATLSEDDKSTMADADGCYLSPGIFGARLITPGPQCPPAAGTTYTSVDGKQFLIDCDQDLAGSDLYAFNTEGPTGNEGGFGQCLERCSTYNGCYAIALQGAGCYSEGYTVSASTASNGLLSGRLLNTAAPIPSPSPEPEPTSNVVSPLEAGVFQFLSCYQDTATKRLLEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2XHT8</accession>
    <name>M2XHT8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_39202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XHT8"/>
    <dbReference type="STRING" id="675120.M2XHT8"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272021_0_0_1"/>
    <dbReference type="OrthoDB" id="4357141at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1166"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="476"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME39022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1189" mass="135308" checksum="D0FA96A6E7044D7A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2XME7</accession>
    <name>M2XME7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_72859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XME7"/>
    <dbReference type="STRING" id="675120.M2XME7"/>
    <dbReference type="eggNOG" id="ENOG502RN7W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_496082_0_0_1"/>
    <dbReference type="OMA" id="ASTWGAH"/>
    <dbReference type="OrthoDB" id="10652682at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004029551" evidence="2">
        <location>
            <begin position="17"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="549" mass="57901" checksum="9F35669820E05553" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y0Y2</accession>
    <name>M2Y0Y2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_66932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y0Y2"/>
    <dbReference type="STRING" id="675120.M2Y0Y2"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_3_2_1"/>
    <dbReference type="OMA" id="WGMSIQW"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="109"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME38964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="418" mass="45583" checksum="2691D15C1DC525E4" modified="2013-05-01" version="1">MNEATSKDRIHVLIIGAGVGGLLLAQGLKKVWKQQWGMSIQWALPLLADLLPEDVHSRLQSASVDPHYVFPDAGNAMPVYNAATGEHLKAIPLVKMLRVSRQKFRALLTEGIDVQYNKSFRSLRTPEDGPAVTAQFADGSSATGALIIGADGANFIVRDAVFAAGEGQAQHIPYGGWNMHVCYNDAETALAIRKALSPIVAIGVHPKGYWLWLSIQDVPDPDKPETWVFQLQWTRHLEDGSDDLSHIGLSQLKAEAAESFGEPFSTAWTKIPEGTALPANKISIWPPLAIPDDIFKGKVVLLGDAAHAMSFHRGQGLNHGIADAAKLVMSLAAVQKGQKASAELAVLEYETEMIKRAGEEVAISKMNTEMMHDWEKMQASPFMQRGGDKHNFSDHIVGKDILVRYSVWASAEKAVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y3N6</accession>
    <name>M2Y3N6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_35276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y3N6"/>
    <dbReference type="HOGENOM" id="CLU_1885718_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="135" mass="15475" checksum="7730B27FACD3285D" modified="2013-05-01" version="1">MSQRSSLQRTHLSQQPQISHHPSCGQQKTRTTGLVEWNDSSAKRDIQNGATRGRHAADRRSQIENRSEESMKSTRIVDEGAISSVFTWTTFKAKMQPVVGAADRHALLMKWIAVSDERFRTNDGKRMVEKRKRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y3Q3</accession>
    <name>M2Y3Q3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_35291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y3Q3"/>
    <dbReference type="HOGENOM" id="CLU_1354587_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="202" mass="22294" checksum="6E27D0E999973C7C" modified="2013-05-01" version="1">MDETTRVSDVREDSPSGQSQAGEFTRYNEPILSELSQDGGSNKDDLGSKNSGRMNRPSVRERRSYDRRRPGLRGGGGSQEDDEDREHDEGDPAANNDQVDNRISAREEPAVASPVAAREAEEPWEDMVYGYGLRRYQDEEDHVGVPMQKSGGKGRGKRKGKGEGNGNGKDRDTKNGYMGCIATDTHTNGHIDQSYPREQSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y4K7</accession>
    <name>M2Y4K7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase I associated factor, A49-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_89151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y4K7"/>
    <dbReference type="STRING" id="675120.M2Y4K7"/>
    <dbReference type="eggNOG" id="KOG4183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034953_1_0_1"/>
    <dbReference type="OMA" id="LWNHYVA"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="49036" checksum="051AA7534DF51C7B" modified="2013-05-01" version="1">MAEKASSKKRKRPSNGVDTPSKKVAIAGNGDKVKVIHEEAETYPVLLSAPGVNAPGVAFKAYSKAHSSKHTNASRVKPSTHDLLLQSSQHPRLDYTATSNSLDVTQQLSHYVAVYDPILKELRITPAHHLDLRSYLRSEAQEEAEERLTIAKQREALGREFGTKKAKKAIDSKTVNAITQDPKGKGKVTDAQNAILEFVGNSTAGAAAKNDEEEAEALLAAKPIPRPNLAADNVEDVYTFDTLIPPSDARLVPTRDWQDKARAGEEIKFSHRFPAFRVAAAGKSDDRLKLTALRYLALLLEFHDALSNAGRAGKKVPKKDILAKRFSAWPMQLVDAVRRRFADESGQALGKWQQDNLYTHICALSLYIDGWLTDTSNLKDDLKLEQRVISQYFHELGCKVSQPTETEANRYNLKKVERAVTRFARLKLPLDFPKPRAGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIV9</accession>
    <name>M2YIV9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_160585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIV9"/>
    <dbReference type="STRING" id="675120.M2YIV9"/>
    <dbReference type="eggNOG" id="ENOG502SKBT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_0_1"/>
    <dbReference type="OMA" id="WTFRAYE"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME38870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="348" mass="38864" checksum="62E3D989AA20BC88" modified="2013-05-01" version="1">MTSQSVVVFGGTGAQAGPILSIVHPDLSAAGTFKITVPTRNTSSDSAQALTRLPNVRLIQAGYDSEQGLRAAFAGQDACYFIINSFEIREPDEYFWTMRAYEIAAQSGLKHFVYSGARNRLKDTGFNEAYRNSHNVVKAHMSDWLQQQSVETLPWTIVYGGVYAEMLGSVLCPMKQGEEFIFAAPVHEESIIPLMPLDNYGTTLAYILQHPTDFLGQFVDAGAIPSTWPEIVSAFVNVTKKNARFQPIAQDQWFEGAKKKGMDPDSRLPKTASADDPATFTFRKSFGSWWNMWRDNTRENELSGRTKSGDKLFVPGRIATLSEWMERTGYQGEPKEPTKMRREAASFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2YK19</accession>
    <name>M2YK19_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_75125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YK19"/>
    <dbReference type="STRING" id="675120.M2YK19"/>
    <dbReference type="eggNOG" id="KOG0731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025506_2_0_1"/>
    <dbReference type="OMA" id="CMLILED"/>
    <dbReference type="OrthoDB" id="2115716at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="219"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="556"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME39296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="597" mass="68173" checksum="9FC9D136C5378846" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2YK63</accession>
    <name>M2YK63_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_139126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YK63"/>
    <dbReference type="STRING" id="675120.M2YK63"/>
    <dbReference type="eggNOG" id="ENOG502S025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_4_1"/>
    <dbReference type="OMA" id="CKPIDAY"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME39351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="434" mass="48062" checksum="89E07E70789F5C92" modified="2013-05-01" version="1">MTHHTPGNAVVVSIWCLASLAILAVACRLYARFWLVRNGGIDDWTVAVSLVFALGMTVEITQQVHYGLGKPSSQVADIDAENLMKSLWAAIWLYHLAIGFARLSIILQCMRVFPQADPRRTRWLVLYVMMAINTSLQIWGFFSTVFFCKPIDAYWKTIMSDEFCLGRKVVWLFNSSMGMALNISVAVLPLPWIKQMRLPKRQKLMLMGVFVLAGLPCLLAIIRVQSLIQVATSHDPAYDNATLAIFSANEVYVGIVCACLPVMKAFFVRLAPRVTNIAPANKVRDMASWVKGLKRRRRSDTVHLTSVGNTQDHDHRWTSKSALIGTSNSSPQQTTDDTGVIHVECIVEQKVEITKPAKAADITNGTGSSQDDSLWQMNQWDAEAGIQGMKSFAQSTSTTSTSHNRATSRTAISSDYGARGSQDRSGSRQRGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKR4</accession>
    <name>M2YKR4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_75278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKR4"/>
    <dbReference type="STRING" id="675120.M2YKR4"/>
    <dbReference type="eggNOG" id="KOG2223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009825_0_0_1"/>
    <dbReference type="OMA" id="WSKAIGN"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="508"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME39561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="780" mass="87417" checksum="AB79B0AF26DF6252" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2YM60</accession>
    <name>M2YM60_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MmgE/PrpD family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_131534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YM60"/>
    <dbReference type="STRING" id="675120.M2YM60"/>
    <dbReference type="eggNOG" id="ENOG502QVEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026574_1_1_1"/>
    <dbReference type="OMA" id="AFRMDSM"/>
    <dbReference type="OrthoDB" id="10267976at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="288"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME42985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="51097" checksum="5702D880C4D27B5F" modified="2013-05-01" version="1">MSELTATTNGYTTIPVTRILSKFIATSNTTHLTSQITTKVKEVLIDYTAVALGALHNASSTQPIYNAISALQGPGTTGSSTVIGHSSPHFLPQYASLLNSAFAHSLDYDDTYALGTLHAGVTAISAAMTQAELMDTSRNAGDFMLAISIGYEVTCRLGRELGMASYERGFHNTGTAGIFGAVAAIASLKRLSAEVVEMAFGLAGSKAAGSMQYLENGSWNKRLHPGFAVHDAFMCVSLAEAGVVGATKSIEGKMGFLQGYSGGEKDSERLVAGLGQDWVWLESSLKPYPACRMTHCFIEIAGQVWKREGGIKPEMVRNVRLTMPQSSFTLVGDPTPNKIHPMNNIDAQFSVYFQTANALLYGSTTGIQAYHKLQDRGIVELCDKLEVLVDEAMHGFAAVVQIEWQDGRVDKVRQQFPLGEVQHPFTRDRVDEKFHSLADPVYGEKKAQEIIDLIDNLEYHTVGELFLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2YN18</accession>
    <name>M2YN18_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_45311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YN18"/>
    <dbReference type="eggNOG" id="KOG3798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020884_2_0_1"/>
    <dbReference type="OMA" id="EPPERWR"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="118"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038896-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME43340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="399" mass="43599" checksum="A8D7B79B92B790E3" modified="2013-05-01" version="1">MTTVSAVRVTELPSRSPDPTTARSHHVPPPGTGFRNPWPSFQENDGFAALKLKFGNHPEKNHVPVPTGPDGARSDELVKVLKPTWATEQNDKLRATWLGHAGFLVETPAADGCERGVRILFDAVFSERTSPVGWAGPKRYTPPPCTIDELPEIDVICISHNHYDHLDIHTVMPLYQKLKGKVHFVVGLNSQDWYLRNIGCTTDEVTELDWWESRRVDINGLGSIDLTCTPAQHFSGRTLWDRGHALWCSYVINTPATSTSPAKSLYFAGDTAYKSVKAGIACPIFEQIGQVLGPFDLAMLPIGLSSPPEFMSAVHAHPEQTLEIHKAIKSKLSLGMHYGTVRGGLSGAFEPVTDPPRRWREAAQKEDMWAGGGVEGDGSDLDPEKGSCGLCHVGATIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2YN65</accession>
    <name>M2YN65_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YN65"/>
    <dbReference type="STRING" id="675120.M2YN65"/>
    <dbReference type="eggNOG" id="ENOG502SC0Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055842_0_0_1"/>
    <dbReference type="OMA" id="WESGSAH"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="348" mass="37958" checksum="289068644FC41DFF" modified="2013-05-01" version="1">MATHAPVARVPFAPLDNPRLQHLASAKNRQNGLIANASSGKSNITKISPGKRAFEADIYEDFDSENVDPTVVDSPTKKLKNDVKPFTFSLAPQKSMPPPSITPSRMLTPKANMSTPRTPLTAPAGRSPKRKIAKPVRRVSAPFSRNDPPFARSASSLPFSLDAALSGSLKSAGATIQETMPKDWYFEIYQDTSEEEASNLMEHSTLTLDLSSDDEDTKKHDDRGKENTPPEGYSAPAASRSGVAVPKAVKKTELVRRKIVVDEMDDGARSPLSDLETDPFFPEGLHKDSHIVMDGVEEKEMKLDVKALYAKEVVAEKTFLTMPVAAKQGDVKGEIAVWEDLSAEDEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2YNR1</accession>
    <name>M2YNR1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_72883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YNR1"/>
    <dbReference type="STRING" id="675120.M2YNR1"/>
    <dbReference type="eggNOG" id="KOG2483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1384136_0_0_1"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="41"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME43670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="197" mass="22014" checksum="A8EF4E89BCE5CD69" modified="2013-05-01" version="1">MANLDTDALDDISQDDQNGQPETVRGCSGTRKKRARHFSSDERARHRIIERERREAFNTSLLELASLLPALDDTKESLLSKHLIVQESIKQHQSHQAAIDEAERRLLVATAERDALQRQLEQLLLLSGDAAVSNQHPIVQDGLTTGQTGWTPQPSGFSNAMAPSDLWDGHVWVPTNFNRPEAVIETLFDRCQNSAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBG2</accession>
    <name>N1PBG2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_29319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBG2"/>
    <dbReference type="HOGENOM" id="CLU_2306014_0_0_1"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="100" mass="10942" checksum="5501E08591556EE5" modified="2013-06-26" version="1">MKASLVEPGQVRDQIQEVQVAFCAGCGLPVVSIQEDDGSMTVDAIDCGEAQCLEQQLDYVKSRIAESERVLQWLTRSSMEDAMAVLRFMRSTAGTKGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBU9</accession>
    <name>N1PBU9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_74639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBU9"/>
    <dbReference type="STRING" id="675120.N1PBU9"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OMA" id="RPKVQPC"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106057">
        <property type="term" value="P:negative regulation of calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000257">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="13"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME39798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="406" mass="45498" checksum="6C79019D1A4446C6" modified="2013-06-26" version="1">MAAQQPQVQPCRYKTGKTLGAGSYSVVKECVHIDTGRYYAAKVINKRLMAGREHMVRNEIAVLKRVSMGHQNILTLVDYFETMNNLYLVTDLALGGELFDRICRKGSYYESDAADLIRATLSAVAYLHDHGIVHRDLKPENLLFRTPEDNADLLIADFGLSRIMDEEQFHVLTTTCGTPGYMAPEIFKKSGHGKPVDVWAIGVITYFLLCGYTPFDRDSNLEEMQAILVADYSFTPIEYWRGVSMSARQFIKRCLTIDPTKRMTAHEALTHEWIAGPESGRGDEDLLPTVKKNFNARRTLHKAIDTVRAINQLRAGGMGMMDGSMSMNPERLKAAAAKSISDEIKPADEDVDMRDAPHPESVRPMDSMDPRGNAKGQTQAQIEEQQKRQQQAIAGLWQNKQQGQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCT5</accession>
    <name>N1PCT5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_117266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCT5"/>
    <dbReference type="STRING" id="675120.N1PCT5"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="30"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="323" mass="36530" checksum="B1DD86C3B5CC67C9" modified="2013-06-26" version="1" fragment="single">MRLLRTGPFVSGDPTTLELHDFPVVSQVRYAVLSHVWSSPQHEILFSDLLDTCDTTIKRLEGHISVDLATSTLQQRPGWAKLAFALEQADEDGKEWLWVDTACIDRSSSSELAQSINSRWHWLEGAAICYAFLGDVPLERWREMKFVRHLASSWFNDGWTLSDLIAPGHVVFYSMEWSRLGDKHELSRVLSIATQVPVPVLEGARSVQEESVAARMAWAASRQTSLFEDRAYSLMGLFDVSMPVLYGEGSKAFRRLQEEIIRSSDDLSIFCWKDAHICKPLHGLMADSPDAFVHSAGYRAYAFEDVPPFDINNRGVRLSLHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD23</accession>
    <name>N1PD23_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_56459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD23"/>
    <dbReference type="STRING" id="675120.N1PD23"/>
    <dbReference type="eggNOG" id="ENOG502T3NZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1250649_0_0_1"/>
    <dbReference type="OrthoDB" id="3650363at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="221" mass="25111" checksum="9BCE03526EC158F3" modified="2013-06-26" version="1">MPGLRKAALSLGLTHEKIYAKVGADGGRLYLGDVIGQAAAIRKKAAELQAVAEDEERQEKAQRVAEPKAKDDRAKSQRRAFLAEAMQMSDWDPTGTWSIQCEKLSKYDETAPQKLTMQIWRDDFRFDELHEDPDDSTNESEEDDGEDEAGKELEEDSHDPFDDEKIENYPWGKRSRSRKRPEEGAHLPRFHAKFHFAVVEGDMRILPARAQEAIVSEALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDM7</accession>
    <name>N1PDM7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_74869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDM7"/>
    <dbReference type="STRING" id="675120.N1PDM7"/>
    <dbReference type="eggNOG" id="ENOG502RXIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_0_0_1"/>
    <dbReference type="OMA" id="DSHIWYY"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108718" description="Survival protein SurE-like phosphatase/nucleotidase domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME40194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="370" mass="39201" checksum="8448FAFD7EB8A9D9" modified="2013-06-26" version="1">MRFSIAATATAALAASSVSGLNVLMGNDDGFASAQLREFYRLLKAEGHNVVVVSEADNQSGMGGRAVFTNNASLAVNSEYGLIKAGAPSIGQDPTDKNVWYYNGTPAATAFVGLDYVIPNFTDFKEPDLVVAGPNFGTNLGPFLYTLSGTAGYTYASVGRGYPAIAFSGGNSEQRSYTWINKTTASGYPDPATIQAQLAVKVVQALVKNTPKGERLMPLGYGISVNTPFITSLTNDSCINPPFVQTRLTGGADYDKAVFNKTSKLFTYANIVPSGGNVCINGDCSLPGETDILNKGCQSAISVFTVDYDAPIGSDQTDIRHKFDSIAPYNGTGSGSTAPGYGHGGHGSMPWGYQSNQTRHHWSARWNLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE08</accession>
    <name>N1PE08_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_74963</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PE08"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OMA" id="SYIFAKF"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="649"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="715"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1247"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1278"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1322"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1359"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1389"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1513"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="209"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="913"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1542"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME40339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1598" mass="177666" checksum="90DEF5DCE80D51C2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEL6</accession>
    <name>N1PEL6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_75925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEL6"/>
    <dbReference type="STRING" id="675120.N1PEL6"/>
    <dbReference type="eggNOG" id="KOG1572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_771662_0_0_1"/>
    <dbReference type="OMA" id="ARANSQH"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000035">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME38570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="39763" checksum="D85ED7E4D502675F" modified="2013-06-26" version="1">MPYLRSNHFKGTWSEGGAEEVSIMTMGLMGSGRKELNGHIDPQILTKIADIMGEDRIAEGSETTKTKAQEDDEYTSKPPTPPESRPSTPRVTIAECPVRLQPLSVPRNYGAVERNAIYRSGKPAKENLDFIGALDVRTMLTLIDPSADDKKIDAEVYDFIQAFDIKHENVIITPNKDKDGTRISPDSLCQALLIVLNPVNHPVYIHCNQGRHRTGCIVACLRKIQQWPIEEILTEYNTYAHPKPRKEDLAFIKAFDPSIVYEYAKSNQLVGARANSQHPFDSALDICDLASGIPTHETAQTPISHSGSSDSDDYLEMARGRQPRMSDSDGDSTMATDGNGHNDVTSDSAKHLENIFGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFV8</accession>
    <name>N1PFV8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <title>The Genomes of the Fungal Plant Pathogens Cladosporium fulvum and Dothistroma septosporum Reveal Adaptation to Different Hosts and Lifestyles but also Signatures of Common Ancestry.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Okmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H.A."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">NZE10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFV8"/>
    <dbReference type="STRING" id="675120.N1PFV8"/>
    <dbReference type="eggNOG" id="ENOG502T2XZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_547608_0_0_1"/>
    <dbReference type="OMA" id="MERIWAM"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="493" mass="54617" checksum="254E3DDC30152837" modified="2013-06-26" version="1">MASMEATPCETVSQQTISLSVPDAVAPKNWSTEVLFWHLQDTDTFEKAKHDLEMGLGRLLADVPILLGKLARGPKDHPLDIVIKINEGASVAFPHEDAANVPDIPPMGELLSNGLPLMDALRKAVTPATSLEPVVEGSAVFCTKLTRLKDGAALAVGFSHVLTDGITASMMERIWAMHTLHVSRGLPFRKYKLETPDEEIRARLSTPARCDTEADLDSFLEVVSATEARSHLHKDVASAKEAANRTRAIMMGHLAELGEKPEARGFALWKFTPEKLIALKKAASGHDAEDWISTLDALTALFWSRVACALGENVHNHQKSRCIFMISTRQRLQPSVPNEYIGNVFSPAVAACSISTLITHEVGLKAAAQSMRKASKEWTQSRWEAWLSKIISLPADQALSVDRKTFLQKHDFSFNDYSRFQSNDIDWGTHLGRVARTRYLKRALPAGAFGAHVHPRLPDGSLEVSLVCSDELRRRLQKDPVFMRYAELMCFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH77</accession>
    <name>N1PH77_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_36883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH77"/>
    <dbReference type="STRING" id="675120.N1PH77"/>
    <dbReference type="eggNOG" id="ENOG502QPU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306949_0_0_1"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="882"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="964" mass="107080" checksum="C5086C91B7810040" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHG5</accession>
    <name>N1PHG5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHG5"/>
    <dbReference type="HOGENOM" id="CLU_2440831_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="90" mass="10208" checksum="F6BD05B969CE4E43" modified="2013-06-26" version="1">MRRHFGWGAEFFRGPLDSLVCRDYASTQSAANEAEGQADVKFYNTCYICIRVTSHLGHGVRHATVRWTRDSMRLTLMGPREGASMILSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHN6</accession>
    <name>N1PHN6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA polyadenylation factor Fip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_74558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHN6"/>
    <dbReference type="STRING" id="675120.N1PHN6"/>
    <dbReference type="eggNOG" id="KOG1049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039307_0_0_1"/>
    <dbReference type="OMA" id="FDEFTWE"/>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="140"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME41060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="332" mass="35549" checksum="2F07BC84655D54BA" modified="2013-06-26" version="1">MDEDDDDLYGGGSTEQNQLQLKEEDEDEHKMELSEGEEDDDDSDDDVQITLEKPEGAKGPEPPAKQQKTKHERTTSDSKPAKSSTPVKTEGSAAPPTQVKTILTHNGKEGKDFPEIRSKNSIDVNAIPTWTNGKPLTAVDIDADLAENSKPWRLPGTDAKDFFNYGFDEYTWASYCMKQQMIENQIGQIKQEDAQMKAFMGIGGDDKQGGGGMPPMPPGMDMNDPNAMANMMQQFGMDPTQFMQGMNGFGGGMPGMGGMGGMGGQGGQQFQQGGFGSGQNSASPNPQPGQGFQAPQGPSAAGEGYSQQQLDMMNQGMGGGGGGRGRRRGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHP3</accession>
    <name>N1PHP3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHP3"/>
    <dbReference type="STRING" id="675120.N1PHP3"/>
    <dbReference type="eggNOG" id="KOG0835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022000_5_0_1"/>
    <dbReference type="OMA" id="WEDVWSV"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="298" mass="32559" checksum="1A1B54F3CE19111B" modified="2013-06-26" version="1">MAPITEPSHLLNPLATSLQLETSASQLDGVPSELEDSVRFETARLTQAAGVLLRLPQVIIAHAIVILQRFWTGPDGGSLLEHDSKDVAAAALSLAAKPSAQPITPRQVLTSFAYLVSLQPGQLASSTAGAKLDSSWHLSEGQYETGRTTLYEIEAHILRVLSFQTQVALPHTLCINYLQTLDVFQSSAGALVAKVAFEHLNTALLSTQLLYLTHQPSAIATAAIYLAARDVGVKLPEVEWWEVFDLDREDLGFLVVALRSVEGFALEEQRKWSRRKAPMSVAELEAEIERSRILETGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHX9</accession>
    <name>N1PHX9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_26846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHX9"/>
    <dbReference type="HOGENOM" id="CLU_940174_0_0_1"/>
    <dbReference type="OrthoDB" id="10605830at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="296" mass="32479" checksum="A05AFA7D02DE74A6" modified="2013-06-26" version="1">MARTKPKPISKRSSKRKPQAEKTDYSKEKNDKLIAEFKKRGLPKPGRVNKNNLIAVLEQNDREAAASRDEAIKKNPLKDARELSGNGKRGRRVKTAGRLTEPGVREPSEPRTTARPGSIRTKPHAPLARLKLLQEFVLDIAGWVIDEDDDRLNRVIRILGRADRELARLLIQSPPTASLPERASSVGVEGTDARPPQKRRFDSLGAVVAPAPKLKASPPGQVGWDPVIGDTFNLERPSTQGTAVDEGEGEFEAEEDDEEVESEADGEGEEPAEGDGAQHLDEASRALVHFSSDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIX5</accession>
    <name>N1PIX5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_45634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIX5"/>
    <dbReference type="HOGENOM" id="CLU_3147173_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="49" mass="5542" checksum="51C29D9D907BCA62" modified="2013-06-26" version="1" fragment="single">PPTHQHPHPSSLEFIRQQPVASSALVAESSDWLVRFALWRNLSCSLAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ10</accession>
    <name>N1PJ10_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aro3</name>
        <name evidence="10" type="ORF">DOTSEDRAFT_73821</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ10"/>
    <dbReference type="STRING" id="675120.N1PJ10"/>
    <dbReference type="eggNOG" id="ENOG502QPSU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030903_0_1_1"/>
    <dbReference type="OMA" id="QPLVMEN"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="51"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME41535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="370" mass="39891" checksum="EEAD0497D055BFB9" modified="2013-06-26" version="1">MAIDAEAQTYTDDVRVLGYDPLIPPQLLAAELPAPGKSIQTVRKGRAEAIEIIKQRDDRLLVMVGPCSLHDPEAAVEYCARLIQLADKLKDDLCIIMRAYLEKPRTTVGWKGLINDPDIDESFQINKGLRVSRKLFCNLTGQGMPIASEMLDTISPQFLADLISLGAIGARTTESQLHRELASGLSFPMGFKNGTDGSLTVAVDAIGAAAAKHHFLGVTKQGLAAITKTAGNPDCFVILRGGTKGTNYDKESVKATREALKKKSLPEVMMIDCSHGNSLKNHRNQPKVAETIAEQLREGETGIVAVMIESHLKEGNQKVPATGGLAALEKGVSITDACIDWDTTISVLENLADSVRQRRTKSSGKVNGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ78</accession>
    <name>N1PJ78_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_73322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ78"/>
    <dbReference type="STRING" id="675120.N1PJ78"/>
    <dbReference type="eggNOG" id="KOG0075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_10_3_1"/>
    <dbReference type="OMA" id="FRNMWER"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001015">
        <property type="entry name" value="ADP-ribosylation factor-like protein 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME42457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="183" mass="20472" checksum="1A7FE53E0D36060A" modified="2013-06-26" version="1">MVGIFKRIYDWLLSLFWATEMDITMIGLQNAGKTSLLRVLAGGEFTIDSIPTVGFNMKRVQKGHVTLKCWDLGGQPRFRSMWERYCRGVNAIVFIADSADKEALPVAKEELHILLDKPAMEGIPLLVLGNKSDLSGHATVDELIEALDLKKVTHREVSCYGISAKEETNLDAVLQWLIARAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJI0</accession>
    <name>N1PJI0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_73793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJI0"/>
    <dbReference type="STRING" id="675120.N1PJI0"/>
    <dbReference type="eggNOG" id="KOG0106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_34_5_1"/>
    <dbReference type="OMA" id="PREPAYP"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="104"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME41496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="327" mass="36911" checksum="BECA87B582885622" modified="2013-06-26" version="1">MADAGVSNTRLYLGNLPRNATKADVENHFNTHGTGEIMEIKLMNGFGFIEYKDAMDARDVVPAFHGSEFMGERLVVQFARGSNRPREGFEHQPRMAPRPRRTVHRMTITGLPFETSWQDLKDFARQSGLDVVYSEVNRERDPSGTGKGYVEYETAADLATAVEKLDNSEFKGSNVRCISDPQTEIPRPRERYRSRSPGGYRGRGGYGGPPPGGDEYYDRRGPPRGYSPRRDDYRRRTPPPRGYYDDPRDDRYGPPRGGRPPVDDYPPPRGGGYPDDRYGPPPPRRGGYEPEPYANGHGREPYAGRPASPRREGGSYDRRGGYEARPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJS9</accession>
    <name>N1PJS9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thymidylate synthase</fullName>
            <ecNumber evidence="2">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cdc21</name>
        <name evidence="10" type="ORF">DOTSEDRAFT_34346</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJS9"/>
    <dbReference type="STRING" id="675120.N1PJS9"/>
    <dbReference type="eggNOG" id="KOG0673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021669_0_2_1"/>
    <dbReference type="OMA" id="AYGRFWR"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000013">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME43762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="336" mass="37702" checksum="CCE90D173E13401C" modified="2013-06-26" version="1">MSRLNDAERGPAHSTTTTSGEVVQPAVTTPHEEFQYLNLIREILDHGEHRPDRTGTGTLSIPFPSQHRYTLSRPDGSLILPLLTTKRVFLRAVLAELLWFVAGDTNAQTLQNQNVHIWDGNGSREYLDSVGLGHREVGDLGPVYGFQWRHFGAEYKTCHDDYIGQGVDQLAEVIHKLKNNPYDRRIILSAWNPADLKKMALPPCHMFAQFYVSFPSTSQTRADGTKRGTLHTLLYQRSNDMGLGVPFNIASYALLTHMIARATDLVPGSLTHTMGDAHVYMDHKEALEVQLTRQPKDFPTLEIRRGVGCGIDGWTPEDFEVVGYKPHGKIDMKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJW0</accession>
    <name>N1PJW0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_73485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJW0"/>
    <dbReference type="STRING" id="675120.N1PJW0"/>
    <dbReference type="eggNOG" id="ENOG502S13F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1618540_0_0_1"/>
    <dbReference type="OMA" id="HWHKSRI"/>
    <dbReference type="OrthoDB" id="5422068at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="7"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME42677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="150" mass="16978" checksum="C80BDA49860B1B0A" modified="2013-06-26" version="1">MTDNKTKYQAALCPCDSCRLAGNGQAFAQWAYIPTDCVFLDPTGKVPMPENLQWGTLKSCRTATASQHFCGRCGAVIFWNSDARPYLKDFGIGLFDSPDGARAESWFRWRTRKLRHREDGLKRARELMLAVEEGLEGYEEDRQSQTGMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK27</accession>
    <name>N1PK27_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_55414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK27"/>
    <dbReference type="STRING" id="675120.N1PK27"/>
    <dbReference type="eggNOG" id="ENOG502RJH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002672_0_0_1"/>
    <dbReference type="OMA" id="MGLFNKP"/>
    <dbReference type="OrthoDB" id="5335210at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="749"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="779"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="972"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1230"/>
            <end position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1255" mass="135445" checksum="A37F06D5368D8F2E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL41</accession>
    <name>N1PL41_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_25687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL41"/>
    <dbReference type="HOGENOM" id="CLU_1695427_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="155" mass="17735" checksum="EC42A77D1AB3FAC3" modified="2013-06-26" version="1">MSGQGVPTGNYFNFYNTNRGAGFWSRTQPPIDWDGVCSLPGHCGTEDDRELQRCSLRYECALRDESIGVPAWDRPPTLSTRDVCKLPDIAWYYDPVQQERKEIVIPQGQLSTVVSQLRNQQWRILDRYQEFTENLFIEAPPRPTPRSADGQPQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLK5</accession>
    <name>N1PLK5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_73307</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLK5"/>
    <dbReference type="STRING" id="675120.N1PLK5"/>
    <dbReference type="eggNOG" id="KOG3343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086803_0_0_1"/>
    <dbReference type="OMA" id="NELMLHS"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="48"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME42435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="200" mass="22122" checksum="0908D6D75F304157" modified="2013-06-26" version="1">MAPNMSLFSVNAILILSTDDSSRILAKYYSPPHIPSTAVGNNYPGANPYPSVKDQKAFEKGLIEKTAKTTSDVILYDNRVVVFKTEADTMLYVVGGADENEIMLYNVILALRDSLNILLKNSVDKRTLIENYDLASLCIDEIVDDGIILETDPVIVASRVSRPPVQDIPNMQGIDLSEEGLLKLYTFGKQKLGERLRQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM72</accession>
    <name>N1PM72_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_62968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM72"/>
    <dbReference type="STRING" id="675120.N1PM72"/>
    <dbReference type="eggNOG" id="ENOG502SK1Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049221_0_0_1"/>
    <dbReference type="OMA" id="KPFNWQR"/>
    <dbReference type="OrthoDB" id="3503419at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="334" mass="37246" checksum="995B0F369AEC966F" modified="2013-06-26" version="1">MGQSLHRYLEIKVHPDIKHGSYESIRVIGEHSRTPPARVSSIEKTDKPFNWQRPTSLMYDSGTIDLLCFPGPDSVKHYASIVATYLDLIGKDSSVTSYAEPSDRGCMEPLLASNLASLGQVDTVVLGYVHGLKRFISSDWQGGDANDIFAWQKMRASNGTSVAFIGCRVSFWGDIAGNVVRALQRLNGVKTVLYIGKLGTLRPEIPPNQWLATGTTSMLDGELVEWRSVLDPHITCTNNVVRGAHYSLPSVLDETKDWLETHRHTFAFVDPEIGHMAKASIQGGTDFAYLHIISDNIAKKYSYDLSNERLQQVIKDREMLLTGIQDTLEQFFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNJ5</accession>
    <name>N1PNJ5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_171955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNJ5"/>
    <dbReference type="STRING" id="675120.N1PNJ5"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_0_1"/>
    <dbReference type="OMA" id="MFGTPDM"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08252">
        <property type="entry name" value="AL_MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014182">
        <property type="entry name" value="ADH_Zn_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051603">
        <property type="entry name" value="Zinc-ADH_QOR/CCCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME43994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="346" mass="37945" checksum="674D70FB8D51D71E" modified="2013-06-26" version="1">MSQQKAIHYQKPGKASEVFALTTIDKPKAEANDLLVKLKACAVNPVDTKIREGKFPASDVTGYDAAGVVEEAGNGVKGFKTGDEVYYSGALGRQGSTAQYGVIDYRLAAIRPKKFDWVESACLPLVTVTAWELLEEHFNLVQDDPRGKQKEKSILIINGAGGVGSIGTQLARKVFKLGKVIVTASRPETIKHAEKMGATHVISHREALKPQLKEKVGVEGVDYIFICYDTNSYMPTAVEIANPKAKICSIVEITDKLDGMHDSNAFMKQLTFSWELMLSKSVHQYELESQGDILKRAAKLYDDGTLISLENERYILSVENLVKAHEKLESGKAIGKIGLEIGSDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNU8</accession>
    <name>N1PNU8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_71786</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNU8"/>
    <dbReference type="STRING" id="675120.N1PNU8"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OMA" id="GCYRIPV"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="21"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME44099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="536" mass="57636" checksum="007069A18A0632BE" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNZ8</accession>
    <name>N1PNZ8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_43537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNZ8"/>
    <dbReference type="STRING" id="675120.N1PNZ8"/>
    <dbReference type="eggNOG" id="ENOG502SSR5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184810_0_0_1"/>
    <dbReference type="OMA" id="EHWSWDV"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="259" mass="29217" checksum="FF736AF23B7EC014" modified="2013-06-26" version="1">MSDSTLDLALWPSSSRSQSTSLPTMTFNATAAARVFALPEMLELILSNLGTKDLLLLQRTCRSFRDTVEGSIRLKRKLFFEPDWSLEGRIFDPYSKANRPGRKPENNSLLLRAFPGCYPTITLVIVSDGADGGQTTLSPGSAGRGRRGSEHWSWDVCISFPADKKPHHSPAVDYPEASWRKMYLSQPPCQSLYLVRRWQRSIRPAMVREGGITMGDFFDEATAEEPGCYDRKWHQSYVSSDRDWHFEGNIRCSSVEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPW0</accession>
    <name>N1PPW0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPW0"/>
    <dbReference type="HOGENOM" id="CLU_2638050_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="77" mass="8715" checksum="216748BD74D8124A" modified="2013-06-26" version="1">MSITGAMTMGRLLDMVNDARGDLEYGSPAGTCMKRICINLFMTLTDDHPSMLDRQASLRFAVERSGQKKRRRHQRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ27</accession>
    <name>N1PQ27_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_150573</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ27"/>
    <dbReference type="STRING" id="675120.N1PQ27"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035901_1_0_1"/>
    <dbReference type="OMA" id="CFSVQYH"/>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000016">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="16">
        <location>
            <begin position="51"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME45497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="456" mass="49308" checksum="4C8719A26E83454D" modified="2013-06-26" version="1">MATTLLRSFKPSGLKNNLKPLYHARYNATVAPGTPRVAPPTSTRSTKPSFERATFTIRDGPVHHGKSFGARANISGEAVFTTSLVGYPESMTDPSYRGQILVFTQPLIGNYGVPSAERDEYGLLRYFESPNIQAAGIVVADVALKYSHWTAVESLAEWCAREGVPAISGVDTRAIVTYLREQGSSLGKISVGEEYDADEDEAYEDPGSINLVAKVSTKAPFHVPSPNGNAHVALIDCGVKENIIRSLVGRGASVTCLPWDYPIHKSANHFDGVFISNGPGDPTHCKATSDNLRKLMNTSQIPIMGICLGHQLLAMAAGASTTKMKYGNRAHNIPALDLNTGKCHITSQNHGYAVDPATLPAEYKEYFTNLNDGSNEGMIHKTRPIFSTQFHPEAKGGPLDSSYLFDAYLQSVQQYKQNQDVLKGGRDNRPSPLLVDLLAKERVGVAPGVAGVPGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ32</accession>
    <name>N1PQ32_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_170939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ32"/>
    <dbReference type="STRING" id="675120.N1PQ32"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_4_0_1"/>
    <dbReference type="OMA" id="RDRNEFY"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000045">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="197"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME45502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="371" mass="41532" checksum="F2F519817CDF7F00" modified="2013-06-26" version="1">MGSIEHDTSLDFADLPQFPSDVPTAPLLRVNLKALLDGNAAEEEKLWRACCDLGFFYLDLRHGKDQQVDGDGLLESAQQCFGLAEDVFNLPVEEKQKYDLMDKGSYFGYKGYGKGVVDKKGTRDRNEFWNISKDDILGVGERLSNPASISTEEAREKLRNFMVRSHAVVTLVLERLNSKLGLPEWTLQGLHRMQARSGDQVRWVRSPPQEEDDRKQALGEHTDFGSVTVLFNRLGGLQVLPPGREEWAYVKPLKGHCVVNLGDAMVKFTAGVLRSNLHRVVNPPGQQGDQVRYSLVYFNRPEDDVILKVLTGSELIDEKRNEPGFEEGEDTNAKQWILNRAMGRRVGGDWKKGQGTDQSRIEKGSSGVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ46</accession>
    <name>N1PQ46_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_33646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ46"/>
    <dbReference type="HOGENOM" id="CLU_1677848_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108956" evidence="1">
        <location>
            <begin position="19"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="157" mass="17431" checksum="8F5C4A56EEC90105" modified="2013-06-26" version="1">MVVSSAAALSIFALGVSTFVPGRRESIRDIVRCDFHPPREEAPESKLSLTDAARMLRTNETVRHETPSRRTDASVTHSRTQMMPVRPLAARAYTARQQYLSRDPHFSDHAAVEPFTFAMTIGTKGVAVASAALQTVARNTDTRREPFPNARSGQWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQS4</accession>
    <name>N1PQS4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_71434</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQS4"/>
    <dbReference type="STRING" id="675120.N1PQS4"/>
    <dbReference type="eggNOG" id="KOG2847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046747_1_0_1"/>
    <dbReference type="OMA" id="IMRYFKW"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="64"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME45737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="393" mass="44928" checksum="E351D2A3F7D55725" modified="2013-06-26" version="1">MAAQERPYEPPLAWRATSAATLGIVGLLCRSFLYAFNRTETTGLDRFLNMLDERKDEQGRTRGLITVSNHVSVLDDPMIWGVLPHKYFWNSKNMRYSLGSFDICFKNGQRSLLSAFFTYGNTLPTHRSAHSKFGGLFQPTMTQCIKLLSDPHSVQAQAAELNLPEDKTAFPSTDPFSSSALYYSTNGEDSFPAPAAYPSRRHSWIHIFPEGMIHQHPDKVMRYFKWGVARLILEAEPCPDVMPMWIDGPQHVMDNERGFPKPLPRIGKDISVNFGEVVDREKVFEPYRQRWREMKERARRKRLGFFQHVSDHDVDHETELGLVIDDDLKYGKEAEQLRIDVTMAVRNEVLKVRRACSGLPDEDPKRSLAETFRSEGTTAREGPQKDGSSLKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRW0</accession>
    <name>N1PRW0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_71005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRW0"/>
    <dbReference type="STRING" id="675120.N1PRW0"/>
    <dbReference type="HOGENOM" id="CLU_2399656_0_0_1"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="9872" checksum="2AE9C52EAB68BDE1" modified="2013-06-26" version="1">MKMPTSVSVVTAAVVRGGFAGLALAIGLQKYAHIDVQVYEAAEKFSQVGAGIVVGPNAQQATRLIDPASLRSLEEARQLHETPPDEDGLYIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRW8</accession>
    <name>N1PRW8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRW8"/>
    <dbReference type="HOGENOM" id="CLU_2061422_0_0_1"/>
    <dbReference type="OrthoDB" id="4710340at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="119" mass="13149" checksum="F950FC210825B1CB" modified="2013-06-26" version="1">MQHASVRKNQAYGGGLWNPTKLHNPKKDSVQFTFQHIAWARLPHLIDSAVEDMDPNKRAAVKAGVLDVCKGNSKTGHKALPSAHKKRKSGGGPDAPMKLNTLRLSLTSRDVTAKPYYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS90</accession>
    <name>N1PS90_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4267 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_128280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS90"/>
    <dbReference type="eggNOG" id="ENOG502TB1H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1652794_0_0_1"/>
    <dbReference type="OMA" id="WGRNDPL"/>
    <dbReference type="OrthoDB" id="3905156at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16347" checksum="167D8E8EC9C048D8" modified="2013-06-26" version="1">MASRLTSTTTFQYLPPPAECLAILLGLAELSLFGLAGLTGPVEFSRGLGLPIDAPKSESEPPTTSQKTQRALSQLIAARNMQNGALILTFALYTRDRRSLGIAVAAGVITTVADVVVVNAYGLKDVVAFHAIGVVNSVLIGGSLLYWGRGDAWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSH0</accession>
    <name>N1PSH0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_70409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSH0"/>
    <dbReference type="STRING" id="675120.N1PSH0"/>
    <dbReference type="eggNOG" id="ENOG502SDBJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_6_1_1"/>
    <dbReference type="OMA" id="EWIGKPY"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03188">
        <property type="entry name" value="GST_C_Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME46396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23244" checksum="846BD5A3EADAE477" modified="2013-06-26" version="1">MVIDITKPPYGFPEKYQHINPKKRIPILEYDDEIITETTAIMTAMSRLAPETHLFGKTDLEVARTYEWLNWLSGTVHERGLGALFSPQWYSDDVTAHEGISKKARAWVDHCFGLIEDRLANVKTSHASGDTFTVADVFLWVMYRWGYLLKIDMEKHYPSWTKVVAIVVQRQAVKAAVEKEGIPIIRDDRPPPEEGKMHDRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSH2</accession>
    <name>N1PSH2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ras-related protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_71187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSH2"/>
    <dbReference type="STRING" id="675120.N1PSH2"/>
    <dbReference type="eggNOG" id="KOG0394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_6_1"/>
    <dbReference type="OMA" id="TSWKDEF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME45374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22757" checksum="AD8A08992B1ACAD1" modified="2013-06-26" version="1">MASRKKILLKVIILGDSGVGKTSLMNQYVNKKFSASYKATIGADFLTKEVLVDDRLVTMQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNNSKSFDTLDSWRDEFLIQASPMDPESFPFVVLGNKVDVEESKRAISSKRAMAFCQAKGGIPYFETSAKEAVNVEQAFEVIARNALAQEESQDFNQDFPETIPINIGEEQSGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT16</accession>
    <name>N1PT16_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine protease</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_87870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT16"/>
    <dbReference type="STRING" id="675120.N1PT16"/>
    <dbReference type="eggNOG" id="ENOG502SCHB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068119_0_0_1"/>
    <dbReference type="OMA" id="IMSSYEW"/>
    <dbReference type="OrthoDB" id="10037376at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050966">
        <property type="entry name" value="Glutamyl_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008256">
        <property type="entry name" value="Peptidase_S1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462:SF8">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00839">
        <property type="entry name" value="V8PROTEASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="95"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME45554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="304" mass="32849" checksum="378BD13BF7628C7B" modified="2013-06-26" version="1">MARLLSKPLGHSIAIAQAPSGNDSIVPTSLTWSREDLTHSLASSNSTSTSSIFSIQPSNHNFTHATPHYGNGTHNLTKRFINGVDNRYEFDSPNYPWHSIGKLAWSNGVYCSGALIGPRHVLTAKHCFVPNTPGTFSPGFDNGEPYGHGDVTVAIMSSYEWGTPCGWKNDWMILILNERLGDKLGYFGAKLPDKRLEDKAIFEHVGYPGDKGGNEPYRVDGNTIESYRPWDCDATGPYYTDTDCAGGQSGGPHWQPKGVAGADGNYIWGTLSVTIDYGGGVAASGWGSGDQMLGAIIQARTNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTV4</accession>
    <name>N1PTV4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_126199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTV4"/>
    <dbReference type="eggNOG" id="ENOG502SI7R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057896_1_0_1"/>
    <dbReference type="OMA" id="FDAWPSV"/>
    <dbReference type="OrthoDB" id="5372935at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29421" checksum="AF1167C0ADE9FCD7" modified="2013-06-26" version="1">MTSRASSPAPTKRQPFRFFDLPSELRLRIYEYALWTPKPVDLVSDNFRTILPRLALFLVSRRMYSEAYPVFYAQPIRLFPDARSRFYKTKKPLLQRLPTKYREAITTLELQLGPGWSRIPLNQNTRMELGLMECKSLRTLKIFIELDPTNDMIFEGFRGDNATSDTYKWHCVQLLIGIMDQVPSLEVVEFDAYPSVAKNGPLVSALIRKVKEGGKKLVFGPLRGWDKDDSEPGLIGLEADMANMVIGMKAPQTVAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTY6</accession>
    <name>N1PTY6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_71492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTY6"/>
    <dbReference type="STRING" id="675120.N1PTY6"/>
    <dbReference type="eggNOG" id="ENOG502SRIK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435470_0_0_1"/>
    <dbReference type="OMA" id="DEVTACV"/>
    <dbReference type="OrthoDB" id="3624822at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="212"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="381"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="628" mass="64460" checksum="98F99C5A1B54996B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU36</accession>
    <name>N1PU36_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_33422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU36"/>
    <dbReference type="HOGENOM" id="CLU_1038371_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="268" mass="30398" checksum="7844D877442BADCD" modified="2013-06-26" version="1">MTSTVPLDFRTTWLHAERKNQPEVELHDSMRASLQAEQETGVSDDIGAIRTMHRHPADIVLEERPQGRHLIDLLASSLTKLINPSSNGENPAKIFVATVEGSSSLVRSERFPSLRRCERICPKDHRFDRLAWYATCTGALPKVECQERRSRITPWKEREICDGTRPLRLDIAGQTTEYQTRCKTCSAVPDTPIPKAGRNSSRSRQSARQKPAHGITNSSPSTFDKNRLSNETVSRLHAMTTLPQLRSTSKLRFERRRHIAIQVVRKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU39</accession>
    <name>N1PU39_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_70749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU39"/>
    <dbReference type="STRING" id="675120.N1PU39"/>
    <dbReference type="eggNOG" id="KOG3411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108559_0_0_1"/>
    <dbReference type="OMA" id="WAPFVKT"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME46902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16860" checksum="0733F9CD7C557653" modified="2013-06-26" version="1">MPGVSVRDVPADKFIDAYAAFLKRQGKLPIPGWSDTVKLSHAKELPPQSQDWFYIRAASVARHIYVRKTVGVGRLRKAHGGTKNRGSRPSHHVDASGAVDRKVCQALEKIGVLETDEEKGGRRITQSGQRDLDRIAQTTLEQEEEEDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUA7</accession>
    <name>N1PUA7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUA7"/>
    <dbReference type="HOGENOM" id="CLU_1911619_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="133" mass="15201" checksum="A7BBA16865B8BC69" modified="2013-06-26" version="1" fragment="single">MHFQDAKSHETLCNKQQSSVDIRLESPRRFLGENHRERANEAWVEHVTRADETHGRGRLTRIVVSHVQVRFRPAIIKSLVHGVAFASRGHTGVQLAIIFKAQTWRHLLNETYCDCGAGWKTRCCQVARSVQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUB6</accession>
    <name>N1PUB6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_69080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME46972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUB6"/>
    <dbReference type="STRING" id="675120.N1PUB6"/>
    <dbReference type="eggNOG" id="ENOG502QPWC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009666_1_1_1"/>
    <dbReference type="OMA" id="HHIAMMA"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0183">Conidiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="8">
        <location>
            <begin position="80"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="567"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="862"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="781"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="862"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME46972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="920" mass="100313" checksum="3C4F6F81377C7729" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUH1</accession>
    <name>N1PUH1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_41550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUH1"/>
    <dbReference type="STRING" id="675120.N1PUH1"/>
    <dbReference type="eggNOG" id="ENOG502QU55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024572_2_0_1"/>
    <dbReference type="OMA" id="QAFEWHT"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="2">
        <location>
            <begin position="10"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="613" mass="69325" checksum="F2F46B8262544303" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUM7</accession>
    <name>N1PUM7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bul1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUM7"/>
    <dbReference type="STRING" id="675120.N1PUM7"/>
    <dbReference type="eggNOG" id="ENOG502QSAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032323_1_0_1"/>
    <dbReference type="OMA" id="FHSCLMS"/>
    <dbReference type="OrthoDB" id="2283785at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022794">
        <property type="entry name" value="Bul1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04426">
        <property type="entry name" value="Bul1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bul1 C-terminal" evidence="1">
        <location>
            <begin position="374"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="510" mass="56563" checksum="72466F8E1DA8019B" modified="2013-06-26" version="1">MSVSSEHSNDAHNMQSRLRNLYQAHKPEIQIQLHRRRSLYSTFDKIEGLAVLVAPTDTSFDEIEIEFVGTTRTYVERLTTAAAISGKSEAFHQFLKLKQPRLDEHLPEDRVLRAGQKYELPFVFVVPQHLLPRVCQHKIAGPALRDIHLQLPPSFGDKDVELKSESPDDMVPEMASIRYGVFARISKNKEEGDEIVKATIASKARRVRVIPATDEQPPLIVGDDSEYTLRKERTIRKGVLQGKLGTLVVEASQPAPMRLQAHRTEEQQPSMATVFLRFDPVDAKSPPPRLGSMASKLKVCTYFASTARSSFPTKQASLSDLSQGMHSEQLNLSSRCVANVEWTKHDGNVDALRRRDSGCSDVTTGVPEPSDSYKGKSFYTAKVLVPLSLPTNKAFVPTFHTCLVSRIYQLKLELGLHTAGIGGTIDLKVPIQISFHSNGDSSPRSGSIDSSMEMIIDDEIGDYFHSRTNHVPDDALTGRSRIGSQAPVDDAPPGYSFFASQSGRQTVPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUQ7</accession>
    <name>N1PUQ7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_70182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUQ7"/>
    <dbReference type="STRING" id="675120.N1PUQ7"/>
    <dbReference type="eggNOG" id="KOG2957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051277_0_0_1"/>
    <dbReference type="OMA" id="MTYGYMI"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME46095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="366" mass="41249" checksum="576B37C77795E5CC" modified="2013-06-26" version="1">MAEGMFYNATNGYVEGIVRGYRNTLLSGQNYGNLTQCDTIDDVKLQLGPAYGDYLAALPPNPSTSALADKTLEKLVAEFRYLQANATGSLAKFMEYLTYAYMIDNVALLITGTLHERDTKELLERCHPLGWFETMPVLCVATNIEELYNSVLIETPLAPYFKGSISHHDLDELNIEIIRNTLYKNYLEDFHRFVNEEPGIAGTPTQEVMSEVLEFEADRRSINITINSFGTELSKQDRKKLYPNFGRLHPEGTLMLSRADDVEGVRIAVDGVHDYRTMLDQTGMGGGGGIGNQSGGVGGDDGKSLEDMFYQKEMEICKLSFTYQFTHAVVYAWVKLREQEIRNITWISECIAQNQKDRVNNFISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV42</accession>
    <name>N1PV42_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_42761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV42"/>
    <dbReference type="STRING" id="675120.N1PV42"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="OMA" id="KQGTMTL"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="446"/>
            <end position="447"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME46220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="515" mass="56638" checksum="6A6DCEE989877978" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV56</accession>
    <name>N1PV56_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_22331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV56"/>
    <dbReference type="HOGENOM" id="CLU_1845045_0_0_1"/>
    <dbReference type="OMA" id="VFEGHAY"/>
    <dbReference type="OrthoDB" id="3645319at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="139" mass="15639" checksum="D7ABFBE0814A3444" modified="2013-06-26" version="1">MDSEPLYLTYEHKANGRNMVPNGVSFMSEYDLVLALSQREVIPRTSGAVTHLHLRTDDDVRKVSKRIKPGCTSIEIYQADLMTEEEKVAAAKTKKPKGEREEVPWMVFLGHVFEGHAYEELIILVPELVAKGGKEAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV90</accession>
    <name>N1PV90_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_169698</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV90"/>
    <dbReference type="STRING" id="675120.N1PV90"/>
    <dbReference type="eggNOG" id="ENOG502QRYY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006524_0_0_1"/>
    <dbReference type="OMA" id="IYMHEIG"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="775"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="780"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="826"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME46863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="911" mass="100815" checksum="57DFB1D97C41BEFE" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVE7</accession>
    <name>N1PVE7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_69390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PVE7"/>
    <dbReference type="eggNOG" id="KOG0059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001640_2_0_1"/>
    <dbReference type="OMA" id="WKNWIVL"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001345">
        <property type="entry name" value="Related to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="817"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="968"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1010"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1039"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1074"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1110"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1153"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="456"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1218"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1488"/>
            <end position="1517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME47446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1595" mass="174709" checksum="96B4C2295DF7BDBB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVI5</accession>
    <name>N1PVI5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_70387</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVI5"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="OMA" id="LYPWANG"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME46365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="78882" checksum="8AFF661664C4798F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVK1</accession>
    <name>N1PVK1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVK1"/>
    <dbReference type="HOGENOM" id="CLU_2306018_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="100" mass="11260" checksum="F66658F22F6258EC" modified="2013-06-26" version="1">MLPKKCTSTYLNSAHHRSRPKVGRGRADWWSALLHDPAIDVDNDMHCRLVLYVLSAREYDMRHGTEIQDAFPLTLLVLRASARAVYQSVSSRPSHDSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW75</accession>
    <name>N1PW75_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_60168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW75"/>
    <dbReference type="STRING" id="675120.N1PW75"/>
    <dbReference type="eggNOG" id="KOG1869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067891_2_1_1"/>
    <dbReference type="OMA" id="LAHMRPR"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="54"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME47771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="169" mass="19391" checksum="298721CD54F11F1C" modified="2013-06-26" version="1">MSSNVGLTTPRGSGTSGYVQRNSANLRPRDNPKPYPSDVDSIKHRQRQPDKEILEHDRKRAIEVKVFELRDELEDEGVDEDEMDDRCDALRKKLESEQSKFGGGPAAKGLKSHQVHELARAKIDESEKLRRALGISKDYEEGSHWKRQEERKLETERERGKGEIGRARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWF0</accession>
    <name>N1PWF0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_51153</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWF0"/>
    <dbReference type="STRING" id="675120.N1PWF0"/>
    <dbReference type="eggNOG" id="KOG1867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_6_0_1"/>
    <dbReference type="OMA" id="CEREGND"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="133"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME47851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="632" mass="69450" checksum="EF11ADA2232344BC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWQ2</accession>
    <name>N1PWQ2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mis12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_21210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWQ2"/>
    <dbReference type="eggNOG" id="ENOG502S72R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046437_1_0_1"/>
    <dbReference type="OMA" id="EHFSYPP"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="246"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME47428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35470" checksum="CEED4870EB3ABCC4" modified="2013-06-26" version="1">MASQKQTTNALLTEHFRYTPLTLLDDIINTVNELVFRAVNAIEEGFGGTTAQQLGFQLDEETAASLPNEEARRERLAELKHNEVDNGIVKLESLLNATIDKDFDKFEIYTLRNILAVGHAEEDLANWVRLDHYKGIDVVSAEEVPALLTPEQVQLQRRKLHEAAKLNIMLKAEEAKNAATLSQLSRLIGAEPKQEGQDGKSEAPFAFLKSSAVTAQAQNLAQDTLGTLKQIPMLQQLLEKLKDAMQNIPNPRQSRFDHSDSREGRRRQYLNAQTRRALERNGVDPESGVGSSLNAGRRMSREELEGIESVAHALGGPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWX6</accession>
    <name>N1PWX6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWX6"/>
    <dbReference type="STRING" id="675120.N1PWX6"/>
    <dbReference type="eggNOG" id="ENOG502QUVC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005053_2_1_1"/>
    <dbReference type="OMA" id="WIAGLDQ"/>
    <dbReference type="OrthoDB" id="5300331at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF2">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="384"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="896" mass="98548" checksum="7AFEBB34304A58A0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXD6</accession>
    <name>N1PXD6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXD6"/>
    <dbReference type="STRING" id="675120.N1PXD6"/>
    <dbReference type="eggNOG" id="KOG3069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034301_0_0_1"/>
    <dbReference type="OMA" id="ELWTYPT"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="486" mass="54514" checksum="BDC8E8A779D2A3F6" modified="2013-06-26" version="1">MSEHKTEDPPQSLIPHLRTILDDLRKEQYPDLPNPEGLKRRASVAFILRVNPSYAHWPESRTQKHDDLESYFNQDWAQHGEAEVLFIKRASRKGDRWTSHIALPGGKRDPEDADDQAAAVREAWEEVGVDLNKYAIECGNLPQRLVTAHWGKKPLLVLCPYVFLVTQHEIPPLKLQPTEVASTHWVPLRSLLSPSHRTIAFEDVSSRIANQETGVKKWMLSMILGKMMFAAINLEPTESLHSVESPAQDTLQDTRHARLGGIDRLKEWGSRFWRNDIFNQFPPPKKDGPLLLWGLTLGVVSDFLDLVPPHNALELWTYPTFTPFDVRFAVWLLTYNFKNRKRAELQSGAEFKAMKPSFGGASESGVDIASAGASGYATPDGAAATFPEDPSVSSTVFVERPNELLRKALQPDETGLHGLGSGVGAGEVREKKAAVQTMLEGYYVIVRQAVAMALIGRASIAVIFAVLLWKRFPTLRTGKMERFLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXK4</accession>
    <name>N1PXK4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_31482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME46959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXK4"/>
    <dbReference type="HOGENOM" id="CLU_2183869_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="109" mass="12450" checksum="4F0ECB381DB500AB" modified="2013-06-26" version="1">MIQDAVAKARRKPGNGAMNAKERQPRLQSWLVSTPQSLCDEIEVILGQRAFEEPTRELAQRFLEWNTKILSLGTHYEYDKKYAEVFLSSDVGGKPVITARTTMTRMEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXP2</accession>
    <name>N1PXP2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_69203</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXP2"/>
    <dbReference type="STRING" id="675120.N1PXP2"/>
    <dbReference type="eggNOG" id="ENOG502SMBT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_417974_0_0_1"/>
    <dbReference type="OrthoDB" id="4225201at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110287" evidence="4">
        <location>
            <begin position="17"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME47160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="656" mass="72130" checksum="43000AE50795B940" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY92</accession>
    <name>N1PY92_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_69209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY92"/>
    <dbReference type="STRING" id="675120.N1PY92"/>
    <dbReference type="eggNOG" id="KOG0874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043293_0_0_1"/>
    <dbReference type="OMA" id="FFIFWDR"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="202"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME47169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="487" mass="54254" checksum="8E4DA55DEE2D04D1" modified="2013-06-26" version="1">MANATMFYDLPPLPDYTLKPLPPIVPGLDDKYLTMALPVIAYWGVSLFFHLIDEWDLFPQYRLHTPAEVLKRNHVSRWDVFRDVIIQQVIQTIVGIALTLMDPDPFYGKEDYDVAWWAQNVRLAQRAIPVALGTIGLDAKTLANNLGTSHAMLASAVSGGIYPELIQNMTLLGESVPAPAFASWELLTAKAIYWVGIPAMQFLIAICIVDTWQYFLHRAMHMNKWLYTTFHSRHHRLYVPYAYGALYNHPFEGFLLDTLGTGVAYLLTGMTVRQSMWFFTMSTIKTVDDHCGYAFPWDPLQHVTSNNAGYHDVHHQSWGIKTNFSQPFFTFWDGFLGTKWTGGDVSARYERARIAAQKKIDADATVTGSTPAESAEQDKVYARDAARASTSARKVQSAADPMIPIGKAANQAIGSRQQVLDDSAAGGVQIIAEESAEELKARTRLRQFPRKRTTSSGMGLKGFADRVGESLHGKGTGVLGVESRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY95</accession>
    <name>N1PY95_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_18942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY95"/>
    <dbReference type="HOGENOM" id="CLU_1643657_0_0_1"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="161" mass="18296" checksum="6DCFE7C4128F041F" modified="2013-06-26" version="1">MALVVIKLKGVGHGGGERMCSGLYLSQAPEAPTKKCHFFTIPPELCLEIHSLVLADHNITRYTGKLQDPPLLRACRLIRNESIEVYNTRMEAISQGYLARVEEAESVLAAKRRRRRNGHRGDHWRVGSAKHQATFCRGFQEHAAQTVHEKRRALREEGFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYA1</accession>
    <name>N1PYA1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_97708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYA1"/>
    <dbReference type="STRING" id="675120.N1PYA1"/>
    <dbReference type="HOGENOM" id="CLU_004184_6_2_1"/>
    <dbReference type="OMA" id="RIRCELY"/>
    <dbReference type="OrthoDB" id="3921930at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="40"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="129" mass="14501" checksum="9D396C0E4FF62F0D" modified="2013-06-26" version="1" fragment="single">YTSLGGDRKIRVLVLQAPTFQDEAVQCSLEETELDANARYSALSYTWATETGDATKSKSIELDGKPFAVTENLHSALLRIRSDKQEPQRLWVDAVCINQCDEEEKSRQVSMMEHIYSFATKVIGWLGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZA2</accession>
    <name>N1PZA2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP-dependent RNA helicase DBP8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_76016</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZA2"/>
    <dbReference type="STRING" id="675120.N1PZA2"/>
    <dbReference type="eggNOG" id="KOG0340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="OMA" id="GMPYPKQ"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="83"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="282"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME48333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="54292" checksum="0316E669D6779647" modified="2013-06-26" version="1">MAVTSIIAVSSISRIKKRAAPPIVKLYPPPDTKDLESLPTSIQDVIDTNDNSTFPDLGTDKWLVSALSHMSIKWPTRIQKATIPQILAGRDCIGGSRTGSGKTIAFGVPILQQWARQPSGIFALIMTPTRELALQIYEQFQAIGGSQGVKCVLVTGGADMRQQAISLSQRPHVVIATPGRLADHIENSGEDTIQGLKKVKYVVLDEADRLLASGGKGSMLPDVETCLDYLPQGSQRQTCLFTATMTPEVRALKEMPRAKGQQPVYVCEVDIDSLAIPDTLTQTYQLVNVLHKEKYLHVLLSTPANVEKTTIIFCNRTETANLVEYLLRLLEHRVTALHSGLQHTDRVNNLARFRARAARILVATDVASRGLDIPDVGLVINYDLPRNPDDYIHRVGRTARAGRKGTSISLVGQRDVELVKAIEERVGREMVAYAEEKINVESRVIKEALNVVGDKKREAMLAIEEGRDVKGNRRRGFGGMDRKANKKQRAAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0F4</accession>
    <name>N1Q0F4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_103922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0F4"/>
    <dbReference type="STRING" id="675120.N1Q0F4"/>
    <dbReference type="eggNOG" id="ENOG502RXU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033727_0_0_1"/>
    <dbReference type="OMA" id="IPLFVNH"/>
    <dbReference type="OrthoDB" id="18110at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524:SF1">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME48743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="61932" checksum="7BC10E91AE2EAB34" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q147</accession>
    <name>N1Q147_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_123157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q147"/>
    <dbReference type="STRING" id="675120.N1Q147"/>
    <dbReference type="eggNOG" id="ENOG502SS3N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1372728_0_0_1"/>
    <dbReference type="OMA" id="WWFARLE"/>
    <dbReference type="OrthoDB" id="2830640at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="193" mass="22401" checksum="C0AF0BE74F5F4B85" modified="2013-06-26" version="1">MREKVDQQTRYSEQVQRDLEMMPRRIDNQSKALFNIIAMRDNKLNIELAASSKRIAEESRLDNLLSVKLAKATADVAEQTRQDSAAMKTIAVLTLTFLPGTAVASFFSMNGMFNWEPSPGQSLASPYLYVFFVVTIPLTIIVYVAWWYWFRRVQKEFQKNYETSDFAAVEQDLMKRMRTATNSWQMTGRQEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1B3</accession>
    <name>N1Q1B3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_30374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1B3"/>
    <dbReference type="HOGENOM" id="CLU_1510565_0_0_1"/>
    <dbReference type="OrthoDB" id="10551139at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="178" mass="20183" checksum="1A9938777E8C203E" modified="2013-06-26" version="1">MPRLSTVSSASPYPTGGRRSRPRGDSYRNPPNMSRLQLSEEHRRPRRRMSAVSPSSKGTMPRRKSVRFDDGGRPSTRQHSSSSVQQQRPKTFTKDAPPAAISESARDTARRLYHRKPSDGGRPAARPTVERSASTRSLNTTRAEAGTNVGGRHSSRRYDHHHDDNRRDPYELRSSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1U5</accession>
    <name>N1Q1U5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_67491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1U5"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OMA" id="FAGWWTW"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="13"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME48469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="520" mass="57115" checksum="6FB255DCBCD39BB3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q266</accession>
    <name>N1Q266_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_40950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q266"/>
    <dbReference type="eggNOG" id="ENOG502SVU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_451282_0_0_1"/>
    <dbReference type="OMA" id="QMKSMEV"/>
    <dbReference type="OrthoDB" id="4448936at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="605" mass="68747" checksum="AFDEB68AA143DA45" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q279</accession>
    <name>N1Q279_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_59031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q279"/>
    <dbReference type="STRING" id="675120.N1Q279"/>
    <dbReference type="eggNOG" id="ENOG502QTYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1315383_0_0_1"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="209" mass="23001" checksum="BA075D27E46ADAEC" modified="2013-06-26" version="1">MADSASLVQYGYFATIHIPSDDCRPNVLDDGNSRQYDMADYHVLSMDDTGIKVIAHAGVAVSHSLEGPSKPGKEPFARIHGVDPVVLVDADGAAYLCFGGPDKFDGEAYQTMEATEGVFDLVINDSDGKPIQASEHDRRFFEAAWMDDGQWPDGRYLFSCSTGDTRFIVCQGRILGPFQGWTTRHSIVEFKANLAYDDAGRRSLARPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2F4</accession>
    <name>N1Q2F4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_68633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2F4"/>
    <dbReference type="STRING" id="675120.N1Q2F4"/>
    <dbReference type="eggNOG" id="KOG2890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043563_1_0_1"/>
    <dbReference type="OMA" id="EIHFWEV"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="40847" checksum="C5B6FF17A9093C03" modified="2013-06-26" version="1">MPRINLPPLTRGLLLVVVALSLLNAVLRTNRWRNSLDSTPSAIAATNYLSSPQWAIPYLVLIPTKSIRYPWTFVTGALVENNLASMAISASVVYFGGKYLERAWGSREFAKAILCITMIPNIVTFFIYALWHGVTGHSPEFPTPLNGLVALEAGFLVSLKQLVPEHTVSIFKGVIRMRIKHFPAVFVVANMLSGPFLGTDTALWLSLFGFLTSWIYLRFFRISEISSTATAGHGSVVKGDASDTFAFVAFFPDVIHPILAPICDGAYNTLVQMRLCTPFSDEDIEAGNESAASRSEAGLPSIMNNRGSGGGGRRAEAERRRALALKALDQRLSAAAANRTASPAPTVTTIQATLTSEIPSTNTGAADADNATTAKEAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2M2</accession>
    <name>N1Q2M2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_41092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2M2"/>
    <dbReference type="STRING" id="675120.N1Q2M2"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="OMA" id="DFWIDLY"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF4">
        <property type="entry name" value="ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="108"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="676" mass="75375" checksum="4C3D206CE57A367B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q312</accession>
    <name>N1Q312_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_49387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q312"/>
    <dbReference type="eggNOG" id="ENOG502RMDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_394323_0_0_1"/>
    <dbReference type="OMA" id="YYTHEWI"/>
    <dbReference type="OrthoDB" id="4152607at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="699" mass="80263" checksum="ADD383EA3B9B076D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q389</accession>
    <name>N1Q389_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_119478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q389"/>
    <dbReference type="STRING" id="675120.N1Q389"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OMA" id="AVNHMGH"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF33">
        <property type="entry name" value="OXIDOREDUCTASE BLI-4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME50256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="341" mass="37116" checksum="61D4C0F98D95AD61" modified="2013-06-26" version="1">MSSTLDAVKSTFSQNLGGVAQNLTPAGQNFSIDEVPDLSGKVAVVTGGSEGIGYACTHTLLSKGVKKVYILSVSQEVVNGAKEAVKSELGEERANATEWIQLDLSDWDKTVEVAKKLAAENERIDILINNAGRGIMTMQLTDKGVDRHMAVNHMGHVLLTSYLLPTLKKTADAGNTVRIVGLSSNAHEQSPKDTEFESLDELNQDLGPMVNYGRSKLAAILYARWLARHLTKEYPQILANATHPGVVNTKQSIEDIHEPYPLAGYVVSTVMRPFKKDVFEGALSTLYAATTTQNSGQYICPPAAVEPGSELSRSENLQDNLMRLTQKVLKEQGGLEHVQFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3E6</accession>
    <name>N1Q3E6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_41333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3E6"/>
    <dbReference type="STRING" id="675120.N1Q3E6"/>
    <dbReference type="eggNOG" id="KOG1651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029507_2_2_1"/>
    <dbReference type="OMA" id="TFPMTEK"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061692">
        <property type="term" value="P:cellular detoxification of hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME50202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="182" mass="20111" checksum="06C33325EB45DE40" modified="2013-06-26" version="1">MSSATTFYDFKPNDKKGKPYDLSSLNGKVVLVVNTASKCGFTPQFEGLEKLYKEVKAAHPDFEILGFPCNQFGNQDPGNDDEIQSFCQVNYGVSFPVLGKTDVNGPNANPLWEWMKKEKPGIMGLQRIKWNFEKFLVGRDGKVKQRWASTTAPDKLKSAIEAELKTAPNASKAAAEKPTATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q404</accession>
    <name>N1Q404_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_20365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q404"/>
    <dbReference type="HOGENOM" id="CLU_1288871_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="214" mass="23562" checksum="40332CEAC32782F4" modified="2013-06-26" version="1">MTPAGPDTNNPHAPRSVSESSVITCEHDVNDVDADYQVFSEPIVQVDGELNLTGGWVLRKHVSPKGGDTISIFPERQKGTRANLAESIEKHMNSDETLPRYKGWVYVLEGDKNSIDPVETSTIRGDRLRERQNEGIILRRRGKQTAFNAPEGLADKTDAQTQEKTSNTSQPAGPNVILAKRKSAGSRAVRGCVEDLTPVTCCLIIPKVKRKWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4H5</accession>
    <name>N1Q4H5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptide hydrolase</fullName>
            <ecNumber evidence="15">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DOTSEDRAFT_68948</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="15"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4H5"/>
    <dbReference type="STRING" id="675120.N1Q4H5"/>
    <dbReference type="eggNOG" id="KOG2194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006412_1_0_1"/>
    <dbReference type="OMA" id="FCHTFVN"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000057">
        <property type="entry name" value="Vacuolar membrane protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="674"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="18">
        <location>
            <begin position="172"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease transmembrane" evidence="20">
        <location>
            <begin position="454"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease C-terminal" evidence="19">
        <location>
            <begin position="766"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="608"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EME50243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="989" mass="109621" checksum="E219F7C18F264DCA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4T9</accession>
    <name>N1Q4T9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_68479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4T9"/>
    <dbReference type="STRING" id="675120.N1Q4T9"/>
    <dbReference type="eggNOG" id="KOG0155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013872_1_0_1"/>
    <dbReference type="OMA" id="MLKSTYT"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="FF" evidence="3">
        <location>
            <begin position="315"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="3">
        <location>
            <begin position="388"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME49714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="583" mass="67502" checksum="CF232ACDC9243025" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4X2</accession>
    <name>N1Q4X2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="1">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_68552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="1"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4X2"/>
    <dbReference type="STRING" id="675120.N1Q4X2"/>
    <dbReference type="eggNOG" id="KOG2161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005386_0_1_1"/>
    <dbReference type="OMA" id="ERTKYWK"/>
    <dbReference type="OrthoDB" id="14419at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="4">
        <location>
            <begin position="446"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="3">
        <location>
            <begin position="723"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="934"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="948"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME49794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1041" mass="121237" checksum="7E6F2892F397D47D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q529</accession>
    <name>N1Q529_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_31090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q529"/>
    <dbReference type="STRING" id="675120.N1Q529"/>
    <dbReference type="HOGENOM" id="CLU_509011_0_0_1"/>
    <dbReference type="OMA" id="QQYHCCE"/>
    <dbReference type="OrthoDB" id="10659692at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="535" mass="60494" checksum="37A2C28CEBC9227E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2WN29</accession>
    <name>M2WN29_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">prephenate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_72721</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WN29"/>
    <dbReference type="STRING" id="675120.M2WN29"/>
    <dbReference type="eggNOG" id="KOG2797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_5_1_1"/>
    <dbReference type="OMA" id="PLMIYRE"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000034">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="267"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME43413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="355" mass="39254" checksum="509D2A8D18ED057B" modified="2013-05-01" version="1">MSEKPAVAFLGPKASYTHQATVSQYPEARFDLQPQVSIEDVFSAVQSRAAAHGVVPFENSSNGSVVFTLDLFADLNGRYPDILVEGEVYIPVRHCLLGHFPRKSRTASESSQERRRTDLPWRRLKTEDSPSASGNVAPIQAMPQPGTPRVKPACDLKHIKKLYSHPQAWGQCKLFLSTYLKGIERQDVSSTSKAAEYVAQDTTGTSAAISSKIAADMNNLDVLAEGIEDNEGNSTRFFVLRRTNGASPHPSLGLDEQTEMEQFKSLVSFKVSHESPGALADSLAVFKEHGLNLTSINTRPSGELVWHYIFFVELKGRKRPDGEGGAVNKAFEDLSKVVTNWRWLGSWENKLHVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2WNR6</accession>
    <name>M2WNR6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone-binding protein RBBP4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_72875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WNR6"/>
    <dbReference type="STRING" id="675120.M2WNR6"/>
    <dbReference type="eggNOG" id="KOG0264">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020445_3_1_1"/>
    <dbReference type="OMA" id="PHEEGCL"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="80"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="335"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="380"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="437"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME43658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="491" mass="55411" checksum="639CFE8CF516D6E3" modified="2013-05-01" version="1">MAGFGTHARQRSKSHPRWLTELKAVNTDRNFLSNPDVPPSDTASSHYPESVAETYLPPPPAEMSGQQEDKAIIENKIINEEYKIWKKNSVFLYDIMYSRALDWPTLTTQWLPDVKELPGKHFRQHRMIIGTHTSGSQDEFLQIAHMNLPQPPAANLADYNPSSEELGGYGASKQPITYSVVQKITHPGEVNKARYQPQNPNVIATWSPDKNLYVWDRSKHPSVPPANREIKPQVTLKGHSKEGFAVEWNPHVEGQLLSGAEDARVNLWDIARDFTKENTTLSPARTFTHHSAIVNDVQYHPQHGKNLFGSVSDDLSFCFMDIRSKSNSRPAIIFKDAHKDAIQTLAFHPKHDKLFATGSQDKTIGIFDLRFPNHGKIHSLEGHKDAVTKVDWHPGESAIIASSSNDRRIIFWDLSKAGAEQTPEDAEDGPPEMLFMHGGHTNRVSDFSWNRNDPWVMCSAGEDNLIQIWRASRHLVETPPTAVPRREVSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2XJK1</accession>
    <name>M2XJK1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_56957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XJK1"/>
    <dbReference type="STRING" id="675120.M2XJK1"/>
    <dbReference type="eggNOG" id="ENOG502RZQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050573_0_0_1"/>
    <dbReference type="OMA" id="YRSQHRI"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME39637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="300" mass="33624" checksum="51130C01F9D44EF1" modified="2013-05-01" version="1">MFGLSYWFLPLFAGCVWLGTLLAMLGRWVALGSPHYDNSFHATQHIAYISDIGATSWGKPLFITGSAVTVVVFDVAFVAERWLRHTGRLTQNYNMTEKILSGFATLFAIIGAAGLILLTIFDTVDYPHVHDAMLVVFIGGYIISAIFICAEYQRLGIHYREYSILAYSFWIKLAFIFVELALAIAFGVMSDKGHYNRAAVLEWTISLIYILYIWSFIIDFLPATRTKHKSDRFPLPLRKQDDEMAMNTEVGGNMMGGPVYTSGGQYPDQGVNGNMQQPVREGQDLYPTHGRTNVGASQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2XM16</accession>
    <name>M2XM16_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_72759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XM16"/>
    <dbReference type="STRING" id="675120.M2XM16"/>
    <dbReference type="eggNOG" id="ENOG502QWA5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022749_0_0_1"/>
    <dbReference type="OMA" id="ADWNIYT"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="143"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="561" mass="60066" checksum="FA8439FB43ABF975" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y1D1</accession>
    <name>M2Y1D1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_91584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y1D1"/>
    <dbReference type="STRING" id="675120.M2Y1D1"/>
    <dbReference type="eggNOG" id="ENOG502RV4Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370461_0_0_1"/>
    <dbReference type="OMA" id="NRIGCPM"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME39114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="751" mass="83649" checksum="7D1699866CBBECE8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y1P5</accession>
    <name>M2Y1P5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_138430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y1P5"/>
    <dbReference type="STRING" id="675120.M2Y1P5"/>
    <dbReference type="eggNOG" id="ENOG502S7JQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104688_2_0_1"/>
    <dbReference type="OMA" id="MRISFAM"/>
    <dbReference type="OrthoDB" id="4487429at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="158" mass="18137" checksum="189AA0330F12CCE1" modified="2013-05-01" version="1" fragment="single">STRDRTRFESDFSKVFGYPSSGGVLILPLDVAVAEYLGISRLKFVHRASDQIEEDAFCNRLRLLGAKWWTSEETYMLKLIEFQEMTEVEKRDGITAGWPGKGLESGVCILRTRADIEMSRMCVSMEERCGTLERWCATFYEDPRDVEEFEGIVLEEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y617</accession>
    <name>M2Y617_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome p450-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">cyp5</name>
        <name evidence="15" type="ORF">DOTSEDRAFT_72901</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y617"/>
    <dbReference type="STRING" id="675120.M2Y617"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="OMA" id="ELTWRVK"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF112">
        <property type="entry name" value="L-ORNITHINE-N5-MONOOXYGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME43699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="543" mass="61139" checksum="FAD44E7756A7B90A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIU7</accession>
    <name>M2YIU7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_29050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIU7"/>
    <dbReference type="eggNOG" id="ENOG502SAXJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059771_0_0_1"/>
    <dbReference type="OMA" id="LYFIQRD"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME38855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="270" mass="29480" checksum="D8F591E30CFD2422" modified="2013-05-01" version="1">MATRAPPSALEPYLRLPPETSLILLTGTLGCSANWLLSRYVGNHLSLEDDDHSTVEPSAVLLVSWLRDATFWKSEIRRTTGLDLTKAIHTNRFTFLDLLTTPTQDYQNLTKRLIDAITTLRMTRPTSKLILLLDSPDIALATSSLTSQSLSTLLLTVRSQVHCTILSCSADLPLLSAATQSTESWPTPIEVESAAFLASQAHSARMVMSVRELETGAAKDVSGVLRVTRGGGCEAFDHIDGDGSGEVREAELLYLVQRDGNVKVFIRGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLR3</accession>
    <name>M2YLR3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CipC-like antibiotic response protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLR3"/>
    <dbReference type="STRING" id="675120.M2YLR3"/>
    <dbReference type="eggNOG" id="ENOG502S76S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143683_0_0_1"/>
    <dbReference type="OMA" id="MAWGWEQ"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14329" checksum="1D4365E383A7556F" modified="2013-05-01" version="1">MFGFDEARDNYQQTYESDNKAELSHELVAGGASFAAFKMFEDHQRKEGKPVSHQFAKELLAGFAGAEVDRLAETKGEDAWDRQKAKREAENRSRDLYDQHYGDQDQYDPNSQPPQHLENQFGQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2YM71</accession>
    <name>M2YM71_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YM71"/>
    <dbReference type="eggNOG" id="ENOG502SZZ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_758692_0_0_1"/>
    <dbReference type="OMA" id="EYSHAID"/>
    <dbReference type="OrthoDB" id="5332773at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="365" mass="40499" checksum="58922526A60F5FF0" modified="2013-05-01" version="1">MAIDAERLVADFKWFDDPVHARQTVDSIVGSWQARCNQAKQKLAAVDAEVVQKEQDDAGSVHDASHKAYASLKQVVAILLDIDNGHTRLSRQDKSILQCLDQAVEQFEALTKVAHVNFQGLGIQAGDCTEFRDRLLFIRGALDEDATQLITDATAAWREGSSRDSEHVRLVADESSCHQRLADAQSAYDTADNWFTGAFTGAGEVDARRNRRDEMRAALERNQEGQRRESTRKTDYYSLAAQIKIASAALVELSSQLQTTAAAALEAFTKIGTAQMAASRLWGGFIDLKNEIWSTDYHSTRDRSLHKVLDLLRADDEVFMLQDCIEKTEREIKQDIAARLGDANLARLLASGAESVEPSSEDLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2YPK0</accession>
    <name>M2YPK0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_25473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YPK0"/>
    <dbReference type="STRING" id="675120.M2YPK0"/>
    <dbReference type="eggNOG" id="ENOG502RV4Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_694492_0_0_1"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="397" mass="43945" checksum="4287A0534A25D0B2" modified="2013-05-01" version="1">MSGFNVKNTDTTPVLVESGPIIPDCRSSITSGLAAIDVEVASAELNPYHEANGPGKGETVASQVFPRFRLLLPREPIIVDFEYQDYHIRGETHHMDHRNKAKRGKRKCRNRVAWICARNSDDVIILDCFVRYDYEYPHIKRILRPEHERFGVTAERLMERNGAVDGRVAEGRSLNSGKNDLQAFYYKDPFAGASEIIDTQHIHGQRSLSAIYLEEFGEEVQKGGQHTAVEDTAATNRIFKLNSSYNREAEQADFNKLTNAEKEAYYATGPFVKFEHYQGNKVLGMPARQISPKSITRKPRAYKGKVKPRATANTSSDEIKGRGDEMDLITAGGQRGTSNITLTANGDINLTAGRDINLNARGGIKVSTGGPKMTSGKKTASKGFSLKGDEPPVLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC81</accession>
    <name>N1PC81_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_57502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC81"/>
    <dbReference type="eggNOG" id="ENOG502SRME">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106738_9_0_1"/>
    <dbReference type="OMA" id="QGPHEGK"/>
    <dbReference type="OrthoDB" id="2148716at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="156" mass="17476" checksum="ABBE349DA0771C70" modified="2013-06-26" version="1">MAQANPIDYFAIRNTIATYCIALDTKDFQLLRHVFVEDVDAVYPFWQIKGVQNVADAIQKRLSPTTTQHALTTQIIEIAEDGNDAQVTTYFTGTHFGQGRWKGQQVTAWGRYLDTLVLTDDKDCLPGASGKWLISKRVVEFMSRLGEEGVMNGEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCS0</accession>
    <name>N1PCS0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_38313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCS0"/>
    <dbReference type="eggNOG" id="ENOG502RMDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1038369_0_0_1"/>
    <dbReference type="OMA" id="WDRIANG"/>
    <dbReference type="OrthoDB" id="3945839at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="268" mass="29918" checksum="FE4DA03A60FBD03E" modified="2013-06-26" version="1">MSGTTDPAIGAIYYPDDAFKKGKASPKRRQSDRKDSAQDDYNRRDYSLSRVPSSQGSSESRRESPERRRSRRSEDDRRRRYSRNWSRSPSPRRYGDEKEDTEKPWFKKKTLWATIASIASVASVAAVSMSTQATRQSAAATRESAQATKKSARATADAALASHRSADASNRIANGNDLSTRAVVNTAVAAGHQDHRGRYLGPLPPQGVRTPRARRLSWDRIANGKEPGRRHSRDRRSHHSRSSAGHNHRDNRPHAGLLEYHPVAKAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCW9</accession>
    <name>N1PCW9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_65158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCW9"/>
    <dbReference type="STRING" id="675120.N1PCW9"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_2_1"/>
    <dbReference type="OMA" id="TNTWARF"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="91"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="348" mass="38869" checksum="802FF7C7A9FA4007" modified="2013-06-26" version="1">MSARQIWQPLYPGLRQLLDPEYVAFHDRHLRFIQPVEAKVWDRSARGVPSITVQGSPSVSVGNMKDIELPHCQLRVFEPVLQTIEASYAALLWFHGGGWVSGDLESENDFCAYLCQTAQCVVISVAYRLAPECPYPAAAEDAVEALTWLIKEATKPTRFNIDITRIAIGGHGAGGNLAAVLVMEAACLYRSFKPRFQLLILPIIDNCASPGRGWINIHAPWLTPARALWQRSMYLPRGIDPESVREDWQTSPNLAPTKLLAKNPQTWIAVAEHDLLATEAMSFAHQLRQANVQADVKIYEGSTHLLLDLNGVLMKGRQMMWDAAYVLGKAFRPQQYNPWPSPSSIESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDD1</accession>
    <name>N1PDD1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_28026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDD1"/>
    <dbReference type="STRING" id="675120.N1PDD1"/>
    <dbReference type="eggNOG" id="ENOG502SJUN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376430_0_0_1"/>
    <dbReference type="OMA" id="VEHFAMQ"/>
    <dbReference type="OrthoDB" id="3645157at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="737" mass="82690" checksum="AEBD4F75E5F777AF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDD4</accession>
    <name>N1PDD4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_114070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDD4"/>
    <dbReference type="eggNOG" id="ENOG502SXMX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153361_0_0_1"/>
    <dbReference type="OrthoDB" id="3629525at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="63" mass="6768" checksum="9D331DC5679FBE0F" modified="2013-06-26" version="1" fragment="single">MGKAKKSLEAFINGIPDSKLTGLPTTIQTLYKDTDFRLDMQGVQVNKGTGISTLKKTAPKTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDH9</accession>
    <name>N1PDH9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_141098</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDH9"/>
    <dbReference type="STRING" id="675120.N1PDH9"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_120_0_1"/>
    <dbReference type="OMA" id="YLVMEFE"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="316"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="574"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="101"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="247"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME38504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="658" mass="72089" checksum="FD0725094A4700B1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDP8</accession>
    <name>N1PDP8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_74163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDP8"/>
    <dbReference type="STRING" id="675120.N1PDP8"/>
    <dbReference type="eggNOG" id="KOG0373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_3_1"/>
    <dbReference type="OMA" id="ETGSMNY"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="263"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME40502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="461" mass="51180" checksum="5EFBD5F8862F7FA1" modified="2013-06-26" version="1">MVRERDSDVPQPGPAVLTSNAGPDEWLEQAKLCRYLPEADMKRLCEIVKECLMEESNIQPVQAPVTVCGDIHGQFYDLLELFNVAGGMPGEVDERAAAAAATAREKEARAKRTSMSSSGAAMFSASDIEPPTQITDPKVKRKMKRRFQKDSAYTSAASEDGSEPGGVDDEERRGRVRSRSMNESVDEDEDIEDDASEDSGVGVRSSEPSRSKSTAKSNQVDHTNGLQNFIFLGDFVDRGYFSLETFTLLMCLKAKFPDKVTLVRGNHESRQITQVYGFYEECQQKYGNASVWKSCCQVFDFLALAAIIDGKVLCVHGGLSPEIRTLDQIRVVARAQEIPHEGAFCDLVWSDPEEVDTWAVSPRGAGWLFGDKVSSEFNHVNNLQLIARAHQLVNEGYKYHFASQDVVTVWSAPNYCYRCGNVASIMTLGEDLKPDFKIFSAVPDHRRAVPAGRQGRGEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDV0</accession>
    <name>N1PDV0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal Zn binuclear cluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tfc2</name>
        <name evidence="4" type="ORF">DOTSEDRAFT_74920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDV0"/>
    <dbReference type="STRING" id="675120.N1PDV0"/>
    <dbReference type="eggNOG" id="ENOG502S8N8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054609_1_1_1"/>
    <dbReference type="OMA" id="APLTHDI"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000013">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="368" mass="40635" checksum="72CFCB269E5C63D0" modified="2013-06-26" version="1">MSHHRGQLQCLNNTAGSYHSHTMTPQLTHSPVNKMAQPQRNSSQDSTADGIRKRVCKACDRCRLKKSKCDGSSPCSRCKADNAICVFGERKKSHDKVYPKGYVEMLEQQQAQLVNGLQEMYRRLRTADAWEGEALSDTNGAPLTHDILAALGLLEPKHDGSGELETFEDDCESLQSRLIAQGAGLTQRRGSFSSESEHSQHGHARSASRSTPSISKPPTFKQESLYHSAPPSPPQDTPAPVPAPRQQRQSFTAAQLSPLQQNSPLSSTPQFYQDDWYTATSRPELMMRSDFAMQTPDLEHNMGNMQDMTGGFASWDTTPDSFDMNMATFTAPGYPGGHPNAWSSASKSYAMDIDPMDAEFAQFIQVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDX5</accession>
    <name>N1PDX5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_106991</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDX5"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1744875_0_0_1"/>
    <dbReference type="OrthoDB" id="3637582at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME40808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="150" mass="16531" checksum="0CB7023C7201EF67" modified="2013-06-26" version="1" fragment="single">TIPGILSAGGMIKRSATNGWRQWCWIQFSLWTITAFSIMTGYRPPKGRSVYVSATMVQRLEALDLPGLSLLVTGLGLFLVGLNLGGDIYPWSDRRTLEILVSGVVTIGLFGIYEWKATRRGILNHELFSGGKAFAICLMLIFVEGVMLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEG2</accession>
    <name>N1PEG2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEG2"/>
    <dbReference type="STRING" id="675120.N1PEG2"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_0_1_1"/>
    <dbReference type="OMA" id="FQYYPQY"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120019">
        <property type="term" value="F:phosphatidylcholine transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031322">
        <property type="term" value="P:ascospore-type prospore-specific spindle pole body remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120010">
        <property type="term" value="P:intermembrane phospholipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="107"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="339" mass="37906" checksum="57842228A51122B5" modified="2013-06-26" version="1">MAGHQNPHMELDPKYDHYDFPTTAPTSQAGHPGHTTKEQDAAVFQLRTMLEQAGYKKNLDTLTLLRFLRARKFNVEHAKTMFVDCEKWRNEFGGGVDELVKNFDYKEKPQIMAYYPQYYHKTDKDGRPVYIEQFGKIDLEKMRAITTDERMLQNLVVEYEKMSDPRLPACSRKAGHLLETCCTIMDFKGVGLGKAGQVYGYIQKASAISQNYYPERLGKMYLINTPWGFSSIFAVVKRFLDPVTVAKIHVLGGSYQKEVLGQVPAENLPTEFGGKCSCPGGCALSDDGPWQDPQWAKSRKDNTIPATESHVGEGQPANGVAAASAGQQQPVGETVQVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF91</accession>
    <name>N1PF91_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial glyco protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF91"/>
    <dbReference type="STRING" id="675120.N1PF91"/>
    <dbReference type="eggNOG" id="KOG2536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072692_0_0_1"/>
    <dbReference type="OMA" id="RWLNNVK"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33997" checksum="08FED2738363BC47" modified="2013-06-26" version="1">MFALRSFARAAPRTMSRIATTSTIRPAFRATSQHFPKVAAFSTTRNRFDEYSQQLAAKLQNEIDIETEESSASATGSDSNVDAWRAENPAWEIEDSDGKQDVYLSRKYDDEIITVQFSIADFNQEMMDSEEMDSALGDEEDMDVQSGGANTKGSINQGGTANKNFKVAPEDSIAPADREELRDEEDESGPAFPVDVNVLVQRPGKGALKFSLVASDGDFMIQNLVQLPKDIKAASAQDLLKEAHSEFYYGPPFQQLDEDLQGLLESYLNARGVTSSLAIFIPDYVDVKEQKEYLRWLGRVKDFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFQ1</accession>
    <name>N1PFQ1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alkaline phytoceramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_74480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFQ1"/>
    <dbReference type="STRING" id="675120.N1PFQ1"/>
    <dbReference type="eggNOG" id="KOG2329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063293_1_0_1"/>
    <dbReference type="OMA" id="YVITRYI"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF1">
        <property type="entry name" value="ALKALINE PHYTOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME40939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32928" checksum="D6E84106B04DC997" modified="2013-06-26" version="1">MPSRSSTVCADTVVPGSFCEEDYAVTYYIAEFFNTLTSLAYIAYGIHGIRRYKRQGLGLFAEPNLSYWALIGVGIFSGGYHMTLKYYTQMSDELSMHLSIGTLLHQVYTFNEPPNIQRRNTAIIVGVLVPFVIYHCVTDEFLMHVILFFIMSWMVAFRTRKLIRETVKDQGHRRQLRRLVSVASWTSMAAYGIWNIDVHFCPQVHHLKQQVGMPWAVLLELHGYWHIMTAIGAYTFMAIIEFLLSPANLDSHGFGFAWPAKAVLRDISSHAVTPNGHADGQLNGGVRKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGY0</accession>
    <name>N1PGY0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_73717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGY0"/>
    <dbReference type="STRING" id="675120.N1PGY0"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="OMA" id="VRHVMIK"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF3">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE ALDH (AFU_ORTHOLOGUE AFUA_8G02310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME41389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="501" mass="54299" checksum="688451FEB505C144" modified="2013-06-26" version="1">MSDLSVELEAPNGRRWTQPTGLFINNEFVAAKSGKTITSIDPATEKQIATVHAAGPEDVDVAVQAAHKALKDPSWKHLDVTERGKLMTRLADLIEENKELLATIDAWDNGKSYSEALNTDLSESVLTIRYYGGWADKTYGQTISTSPQKFAYTLRQPIGVVAQIIPWNYPLSMAAWKLGPALACGNTVVLKSAEQTPLSILILGKLVKEAGFPPGVVNFINGHGAEAGPSLVGHPLVDKVAFTGSTATAGQIMKTASATLKNITLETGGKSPLLVFADADLEQAVKWSHMGIMSNQGQICTATSRILVQDEIYDKFIEQYVATVKEVSVVGDQWAESTYQGPQVTKQQYDRILEFIEAGKSEGAKVAIGGEPHKHGDGKGFFIAPTVFTDVKDSMKIYREEIFGPVVVVSRFKDEEEAIRRANDTTYGLGSSVFTQDLVRAHRVAAEIEAGMVWINSSQDCDPRIPFGGVKQSGIGRELGEAGLEAYTQIKAVHVNMGTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH71</accession>
    <name>N1PH71_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_55802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH71"/>
    <dbReference type="eggNOG" id="ENOG502TA04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_545147_0_0_1"/>
    <dbReference type="OMA" id="MDAVTRP"/>
    <dbReference type="OrthoDB" id="3650977at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="500" mass="55141" checksum="80EA9B537236A3AD" modified="2013-06-26" version="1">MPSRGSRMLSGLDPQHNVINEAARASVEHLIVDDDPLKHLTRALHNGKSDMLYDMKYHPMDAVTRPNMPATQRHRSKLVSFANDQGDDGDSEGIHSSSQGTEDSEGSDDDAAPNSIPRRGPPPPDREMDPRASRHSSRKEAQKYVDYDRKSHPADYGIPGYQDKVKYMLPTDKPTSVQIAKKRKARLQDSDDEEDGPSIAQPRQPRKQLKSLAKNKTESTTKRGRGRPRKKQDSSDGVDDDEVDALVEEAIRGSQRRPLLVSSVADADELEDDIDMLFSRNGERVHDTSRNSNTLDVSPPSDTPQASTASSHKIPEYIDDRQALQNGGTPVTTDVAFRILLEDFRSDHDAKLMIYKPYIKPFSPPDNDSLVSPPETVDYVSPQGNDDSSLPGAEGFDLTTLSAGREVPDSDDFPSRPGAGDEDDWAEHSSQNQNHFQEQLAITKPRESHGSDDSVLRKLPVLSSGGNEGTEGHGVDLFGDQHQCLEPPVHELVLDAAPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH97</accession>
    <name>N1PH97_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_55462</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH97"/>
    <dbReference type="STRING" id="675120.N1PH97"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024572_2_0_1"/>
    <dbReference type="OMA" id="CVVIMSN"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006968">
        <property type="entry name" value="PRK09441.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="5"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME41712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="502" mass="56921" checksum="4AACA0D53BB83307" modified="2013-06-26" version="1">MPDNATLLQGFEWNVPADGKHWKRLLNALPALKACGIDNLWLPPGCKASSPEGNGYDIYDLYDLGEFDQKGGISTKWGTKDELIALSQKAKELGVGLYWDAVLNHKAGADKKEKADAVEVDENDRNTEVSDSYQINAWLGFDFPGRGDKYSKMKYHWYHFSGTDYNAANEKKAIYKLKGENKGWSETVDDEQGNADFMMFADVDYSHPEVQEDVKDWGKWIVKEVGLTGFRLDAVQHFSERFTNDWVEYVRKETGQDVFMVGEFWTNDTKAMIGWLDKMNHRFALFDAPLLYNFSRLSTTEDADLRTVFDNTLVKAEPVNAVTVVMNHDTQPGQTMDTKIEGFFKPLAYALILLQDAGYPCLFYGDLYGIKGDSPEPPTCSNRLPDMVLARKLYAYGQHEEYLDQSTCIGFVRRGNEEHHAGLACIMSNAGPGEIRMAVGEMHAGQIWTDVLDWQQEEVKIDDEGYGLFKCPGTSVSIWVRKDAEGRDRFPVDFDNDIYKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI61</accession>
    <name>N1PI61_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_110486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PI61"/>
    <dbReference type="STRING" id="675120.N1PI61"/>
    <dbReference type="eggNOG" id="ENOG502SA1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177926_2_0_1"/>
    <dbReference type="OMA" id="MPLIARR"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40135">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40135:SF1">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="56" mass="6582" checksum="4C5773FA0F50CE82" modified="2013-06-26" version="1" fragment="single">MPLIARRFSVTNFLIATSALGFQVFVLYPWHTKLDNDFAELKRENMKLIQRLEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PII0</accession>
    <name>N1PII0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase of the ABC class C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_36287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PII0"/>
    <dbReference type="STRING" id="675120.N1PII0"/>
    <dbReference type="HOGENOM" id="CLU_2096823_0_0_1"/>
    <dbReference type="OrthoDB" id="189459at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046834">
        <property type="entry name" value="ABC_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019195">
        <property type="entry name" value="ABC_ATPase_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149:SF1">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09818">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase of the ABC class C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="116" mass="12680" checksum="6AEE85E686AF8890" modified="2013-06-26" version="1">MQQLIWNEPITLLVSEARASYAHYGVSTVIVIGGLGDWLALSDNVISLYSYVARSITRSAQEVLSQSPSTVLQGQKYCSPPQRVFSLDLDGVKPPFAPRNKIIAIDSHTKHAADNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIJ4</accession>
    <name>N1PIJ4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_74101</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIJ4"/>
    <dbReference type="STRING" id="675120.N1PIJ4"/>
    <dbReference type="eggNOG" id="KOG0652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_4_1"/>
    <dbReference type="OMA" id="NKISHEH"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="246"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME41954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="466" mass="52063" checksum="9E9F550E709E0971" modified="2013-06-26" version="1">MSTLEDLDDMERDGKKEENDDGDKDKKPDQNGDADMKDADGGKKEDEKKEEEDLIDYEILNSSTRDIVARRRLLENDTRIMKSEFQRLSHEKQSMVDKIKDNVEKIDNNRQLPYLVGNVVEILDLDVEKEAAEEGANIDLDATRVGKSAVIKTSTRQTIFLPLIGLVDHEKLKPGDLIGVNKDSYLILDTLPAEYDSRVKAMEVDEKPTEKYTDVGGLDKQIEELVEAVVWPMKEAERFKKIGIKAPKGALMYGPPGTGKTLLARACAAQTEATFLKLAGPQLVQMFIGDGAKLVRDCFALAKEKAPSIIFIDELDAVGTKRFDSDKSGDREVQRTMLELLNQLDGFASDERIKVLAATNRVDVLDPALLRSGRLDRKIEFPLPNEEARAQILRIHSRKMTVDEGVNWPELARSTDEFGGAQLKAVCVEAGMIALRSGQSKISHEHYVDAIAEVQAKKKDTVNFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIY8</accession>
    <name>N1PIY8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_73627</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIY8"/>
    <dbReference type="STRING" id="675120.N1PIY8"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_12_1"/>
    <dbReference type="OMA" id="NHKGPNG"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000409">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="107"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME41276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="613" mass="67659" checksum="CB6EE759071F8C67" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ38</accession>
    <name>N1PJ38_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_73441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ38"/>
    <dbReference type="STRING" id="675120.N1PJ38"/>
    <dbReference type="eggNOG" id="ENOG502SA5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131612_1_0_1"/>
    <dbReference type="OMA" id="FAFWKLV"/>
    <dbReference type="OrthoDB" id="3597994at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="173" mass="18507" checksum="DF8B55BBF06D7E3F" modified="2013-06-26" version="1">MAPSRALPNTSPPTTPSSDEVAVSQQSTTALKNARRNFNYLLNPGNSTDRPGRLRTRAFLRTFRYIAQFIIWRLIRWAKYAAVGMAVATVAATGFGTVVSGAGFVLAPTGIAGSIVAASVWGVGKYVARKANARWKKGGGDLGDEARERASDGMREERMLNEGYEGGGAAVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ80</accession>
    <name>N1PJ80_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ80"/>
    <dbReference type="HOGENOM" id="CLU_2654486_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="76" mass="8371" checksum="D4C5987586526B60" modified="2013-06-26" version="1">MLASRVVVGGLDELRRLRSVRGGDAKTAVLEIDGLFVDTMRLHVFGWCEGRHGKLWKMTPNAVLPMGLAILLHAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ87</accession>
    <name>N1PJ87_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_36801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ87"/>
    <dbReference type="HOGENOM" id="CLU_443445_0_0_1"/>
    <dbReference type="OMA" id="YRTHHAN"/>
    <dbReference type="OrthoDB" id="10563305at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="616" mass="67791" checksum="0780ADA1D496296A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJA1</accession>
    <name>N1PJA1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tfc10</name>
        <name evidence="8" type="ORF">DOTSEDRAFT_55394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJA1"/>
    <dbReference type="STRING" id="675120.N1PJA1"/>
    <dbReference type="eggNOG" id="ENOG502RJRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008511_1_1_1"/>
    <dbReference type="OMA" id="CFWEFIH"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME41620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="728" mass="81266" checksum="3F3FF9B28AC5F43B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJC8</accession>
    <name>N1PJC8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJC8"/>
    <dbReference type="HOGENOM" id="CLU_2223216_0_0_1"/>
    <dbReference type="OrthoDB" id="3648235at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="106" mass="11716" checksum="82DD595324C8BAC8" modified="2013-06-26" version="1">MDGKHYEYPHGCNHPEMPIGRLYGAHRFDHRAASNLYLSSVPVIKIGHVFSTKILLSHSRLLTTLGGRYLQTGTRVWVAFVAALTCLLDYHHDEALSGSSGHFAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJK1</accession>
    <name>N1PJK1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_73938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJK1"/>
    <dbReference type="STRING" id="675120.N1PJK1"/>
    <dbReference type="eggNOG" id="KOG2304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_1"/>
    <dbReference type="OMA" id="MAHPMGP"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="7">
        <location>
            <begin position="43"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="232"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="48"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME41705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35096" checksum="D2A0C377E68C1BA2" modified="2013-06-26" version="1">MLSRRPLSHVVRKPIGAPACLQRRPFSSSRPALADAQAAHVKKLAVVGAGQMGLGIALVAARAAGVPVTLVDTSQQSLDKGLAFADKLLSKDVSKQKLSREDADTIRGRLTPTTKMDDLADVDMVIEAVPEMVDLKTKIFAQLAQTTPAHAILATNTSSISITRIAASTTKDPTDLSASSRVVSTHFMNPVPVQKGVEIISGLQTSPETLATAIEFCKRMGKVPSTSADSPGFLANRILMPYINEAVICLETGVGQEKDIDDIMKNGTNVPMGPLQLADFIGLDTCLAIMEVLHTQLGDSKYRPAVRLRQMVDAGWLGKKSGRGFYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJY0</accession>
    <name>N1PJY0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_73883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJY0"/>
    <dbReference type="STRING" id="675120.N1PJY0"/>
    <dbReference type="eggNOG" id="KOG0894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041481_3_0_1"/>
    <dbReference type="OMA" id="DEENWKW"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180027">
        <property type="term" value="P:inner nuclear membrane-associated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000058">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME41611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="276" mass="30798" checksum="431E02BBFD94D73E" modified="2013-06-26" version="1">MATKAAHKRLTREYQAIQKSPPEFISAHPSESNILEWHYILTGPPDTVYAGGQYWGTLVFPSDYPFAPPAIRMHTPSGRFRCSERLCLSISDFHPKSFNPAWEVSTILLGVLSFMTSEEMTTGSVSAKPEERKAFAARTKWWNSTGGGSTTRTLGSGAVNEEKRLGNGTNRGFGAIKAGDGGKRFKEQFPEVDEENWKWMEEDKIDPQTGKKIGAIAVESYVQECETAVKRKTTPAAAHGAANNQQNWLLRNRWWLIGGVIFAYVVAARLLRDQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKD9</accession>
    <name>N1PKD9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_135670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKD9"/>
    <dbReference type="STRING" id="675120.N1PKD9"/>
    <dbReference type="eggNOG" id="KOG3764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_51_1_1"/>
    <dbReference type="OMA" id="MSGINNT"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="21"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME41746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="445" mass="46925" checksum="4BF26B5EC6F29017" modified="2013-06-26" version="1">MPVLKTQSWRSSKALLIFTATLGLFTAENFLYGFVVPILPYMIETRLHQSPSTTQTFTTTLLVLLGLISIPAAPIIGSLADRCPTRKMPLLLSLLGCAVGTILVALTPSVWAVYLGRILQGIAGTGAWIVGLAMLADAAGGKHLGKALGMAGSFITAGIILGPAIAGVLLQWCGYWWAWSVPLALLAIGLVARLAMIEERKVEKVPNEDDGGNEEAPLLDGERDEGDVKVATARGFYGVMLRKGVVWASIFNVTAFAMVVSGFDATLPVHLRDTFGWGSAPIGSVFLGLQIPAMFLSPLVGWLRDKIGLRWPTSIGWALTAPLLWFAGVPGKDNFLGVGAGARGEGAFVASIVGVGITSAFVRGAGTFQLTTTLRELQAADPNIFGPGGASSRIFSLTEMSFATGLMLGPLICGSLADAVGFYYTSCALGMSIVSRNPDFTLTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKQ8</accession>
    <name>N1PKQ8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_26239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKQ8"/>
    <dbReference type="HOGENOM" id="CLU_2073095_0_0_1"/>
    <dbReference type="OMA" id="NSQSWAD"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="118" mass="12694" checksum="25FF37E1F6D0182C" modified="2013-06-26" version="1">MSTTDASQSATTSAASANFNLGGGGITITTAEAVGLGVAVTFAIIVIIIALVILGYYCSCCGKRKNRLSTIRYEDDQETQTYPQWNSQSWADWNSLPQTHQPSQAQKILGKFGQSRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKT8</accession>
    <name>N1PKT8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_74093</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKT8"/>
    <dbReference type="STRING" id="675120.N1PKT8"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="OMA" id="QMGMDHL"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF5">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="12">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="13">
        <location>
            <begin position="294"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME41936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="413" mass="43172" checksum="233067162E76AED5" modified="2013-06-26" version="1">MAAFLQKGTKNILQKSPNDIVFLSALRTPVTRAKKGGFKDAYDHELLAHVLKATLAANPNLDPAKIDDVQIGTVLSELGGSKAGRMAACHVGVPSTTSVQTVNRACSSGLAAITGIANAIAVGQIDVGIGGGMESMTRNYGSRAIPTQLWEELKNSPEKDAKDCIMSMGITAENVAERYGVSRADQDAFAAASHLKAAKAQKEGLFDKEIVPVTTRWHPNPENPGTTEEITVSKDDGIRPNSSPESLAKMKPAFKETGTATAGNSSQVSDGAAAALMMRRSTAAELGLTSSIIGKWAGTQVIGCKPDEMGIGPALAIPKLLSYTGVDKSEIGIWEINEAFASQAIYCVRNLGIDEAKVNSKGGAIALGHPLGATGARQLATLLPEMERQGQELGVVSMCIGTGMGMASLIVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKV4</accession>
    <name>N1PKV4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_44281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKV4"/>
    <dbReference type="HOGENOM" id="CLU_2306019_0_0_1"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="100" mass="10703" checksum="2C6AD54FF95961C4" modified="2013-06-26" version="1">MSSCWTGLDAYGCLLVYSLLKARRVACRHLSFQTILPRHLPSTTTPFGPHSVDAPSGDTEHPSTSTSSSVPTPSGHMTIPTRDGQATRHSCCASQAELFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL11</accession>
    <name>N1PL11_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_35955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL11"/>
    <dbReference type="STRING" id="675120.N1PL11"/>
    <dbReference type="eggNOG" id="ENOG502S37A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_1"/>
    <dbReference type="OMA" id="YGVQKLG"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="205" mass="22530" checksum="6DE026C96B204C03" modified="2013-06-26" version="1">MDPNFHITTPRLYISYLQASNDSHCDFLVKLWNTPEFVAACGQTRVDTREAARKVIGGRFIDEHKRNGYGTYLVSLKSHVSGTTAGAFQETVEHCKNVGTVSLMRGVPPKALSAPDLGFAILPEDGRKGYAREASQALVDYAERSLCVSDILGLFDPQNHASKGVFKSLGFQDCGVENLEEFGGIPVAIWVKRGMSTDINAYRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL49</accession>
    <name>N1PL49_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_53391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL49"/>
    <dbReference type="HOGENOM" id="CLU_1266864_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="218" mass="23051" checksum="16C5E76DA19754F8" modified="2013-06-26" version="1">MQVVSSLRSGQLIDEFRARGAPTTDDEDIEDSADIEAESEPTGSEYTPSEAAPEDKTNAEVSGDRTNAATPSHAASPTDEGYDVGDAGFQQTQPEDEAQEDATKPEKRDEENEGHQPECEEYAKVPGPEESETTTPSYIAPVTDDTIEKSDEDQGSTAKPKGTDETDAAQTKDATDMPTDAGKESKADTPPAKMSSNETLSPATAPAKDTKPGRKPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL96</accession>
    <name>N1PL96_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar import and degradation protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_45644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL96"/>
    <dbReference type="STRING" id="675120.N1PL96"/>
    <dbReference type="eggNOG" id="KOG2395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007002_0_0_1"/>
    <dbReference type="OMA" id="RLNETKW"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="249"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="435"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME42086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="809" mass="91447" checksum="49E68C487AD523B3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLR9</accession>
    <name>N1PLR9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_130443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLR9"/>
    <dbReference type="STRING" id="675120.N1PLR9"/>
    <dbReference type="eggNOG" id="ENOG502RXKA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029630_0_0_1"/>
    <dbReference type="OMA" id="MAWYHDM"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF26">
        <property type="entry name" value="OS05G0151100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109198" evidence="1">
        <location>
            <begin position="17"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="303" mass="32015" checksum="90CC525608B815BC" modified="2013-06-26" version="1">MYAKIAAVSFAALAAAAPLEKRQSGPNDGQILNYALTLEYLENEFYKQGLANYTAEDFQNAGALPGFYDNLKKISSDESTHVSFLTSALDTAGVTAVQPCTYAFGATDAASFLQTAAVLEAVGVSAYLGAAQLISTKDYLTAAGSILTVEARHSAYLNQQQAPPKSPFPSPFDVPLDLDEVYSLAAQFIVSCPPGQSLPVKAFPILTVVSPTTPVKEGDQLKITTATSVNANAAYFITINGPVKADAARADDDYYVIVPAGVQHGQEYLVFTSTDATPTDDNIVAVGIVNIQDNLYGKTYPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLY1</accession>
    <name>N1PLY1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLY1"/>
    <dbReference type="HOGENOM" id="CLU_2223211_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="106" mass="11767" checksum="DAEA809299B5FB0D" modified="2013-06-26" version="1">MRTCSFAGRSEKRWKREIIVRALKRRDEVCFPDGELLAFLSLSWNSAGLGVSFQLFDGAAMVRRELSSAATTDFDQSAFDVATFVVTGSLAEEVAQLAIRLSVECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMN4</accession>
    <name>N1PMN4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_90056</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMN4"/>
    <dbReference type="STRING" id="675120.N1PMN4"/>
    <dbReference type="eggNOG" id="KOG0412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014853_3_0_1"/>
    <dbReference type="OMA" id="RASECQQ"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="176"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME42765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="778" mass="86026" checksum="C88EA505D25D816E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNA0</accession>
    <name>N1PNA0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNA0"/>
    <dbReference type="HOGENOM" id="CLU_2469050_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="88" mass="9532" checksum="2F5F792977D23BA4" modified="2013-06-26" version="1">MLRLENWFTTSGQSIVLSSLGLITYWEGGDRAFLVDLRDIFGLIKHFPANPFRQQYPSSNGVHMIVVVAVGAVAVGVVLGDGEARQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNA1</accession>
    <name>N1PNA1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_61526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNA1"/>
    <dbReference type="eggNOG" id="ENOG502S5T4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_467092_0_0_1"/>
    <dbReference type="OMA" id="IKLACHD"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="686" mass="75540" checksum="1BA706919C49FAB4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNC0</accession>
    <name>N1PNC0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_169951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNC0"/>
    <dbReference type="STRING" id="675120.N1PNC0"/>
    <dbReference type="eggNOG" id="ENOG502S0PE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057546_1_3_1"/>
    <dbReference type="OMA" id="HTIFDFR"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="137"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="268" mass="29903" checksum="03CDEEC497DE40A7" modified="2013-06-26" version="1">MDERTLPPPFVNVQGIANFRDIGDDKFVRRGLVYRSADPGKATTTGLHRLSQELGIKAIFDLRSTPEIQRDGPEWAGVEVANEDPFAAHGIKRNWTPVFAAKDYGPEQVGLRYQHYTRTGSEGFVKAYYDILIAGSEAYTKIFTHLAQANPSPCLVHCTAGKDRTGVLVALLFMLVGKEKVEIGEEYSLTDLGLEPFKPVFVERLLKNPALEGNREGVMNMVASKEENMLATVDMIEKEFGGSEAYMRKYCGLENGEIEALRRNLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNW2</accession>
    <name>N1PNW2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_71796</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts (via SH3 domain) with PEX14 (via SH3-binding motif); forming the PEX13-PEX14 docking complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxin-13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNW2"/>
    <dbReference type="STRING" id="675120.N1PNW2"/>
    <dbReference type="eggNOG" id="KOG3875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034386_1_2_1"/>
    <dbReference type="OMA" id="EGWFPKK"/>
    <dbReference type="OrthoDB" id="10037838at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11771">
        <property type="entry name" value="SH3_Pex13p_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000128">
        <property type="entry name" value="Peroxisomal membrane protein (Pex13)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="309"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="391"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME44114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="456" mass="47964" checksum="745BB8704F10E97B" modified="2013-06-26" version="1">MGSPMKPWEQSRVGGATSSAAVPTSTSTTTATAATPSSTGAPTLPARTDALTQVATHTASNYSSPYNRPGMTSAYSSPYGMGGMSGYGGMSSYSSPYSRFGGGMGSMYGGGMYGGMGGYGGMGGYGGGMYGQPGMIGPDGQPQSLTQTFSNSTQATFQMIESIVGAFGGFAQMLESTYMATHSSFFAMVSVAEQFGTLKQTLGSVLGIFTIMRWIRTAIARLTGRPPPASSKELTPANFAQFSGAPGPDGQPVSKPSRKPFIFFVVAVFGLPWLMGKLIRALAASQEAQQQQQGQLMGPDGQSQPLDPSKLDFCRIIYDYTPQTQPGQPFQEGIDLAVKKGDLVAVLSKSDPMGQPSEWWRCRARDGGVGYLPSPYLETIQRRTQQAQITAKSAPGSEAGSRLNTMTTNSAGAQSRANSMKITDKENAEIKKAPRLPPGKGGDVPVESFQRAAFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP23</accession>
    <name>N1PP23_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_23239</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP23"/>
    <dbReference type="STRING" id="675120.N1PP23"/>
    <dbReference type="eggNOG" id="KOG0232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085752_1_1_1"/>
    <dbReference type="OMA" id="MSVCPPY"/>
    <dbReference type="OrthoDB" id="5418235at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000003">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME45171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="162" mass="16558" checksum="7457585110279E31" modified="2013-06-26" version="1">MASSELTPKFAPFLGMGGIAFAMIFGCMGAAYGTAKSGIGIANVGTFRPDLIMKSLIPVVMSGIIAVYALVVAVLIAGNMKPPPGTEYSLFNGCMHLACGLSVGLTGLAAGYAIGVVGDAGVRAYMQQSRIFVGMVLILIFGEVLGLYGLIVALIMNTRASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPI0</accession>
    <name>N1PPI0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_52281</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPI0"/>
    <dbReference type="STRING" id="675120.N1PPI0"/>
    <dbReference type="eggNOG" id="KOG2464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019103_0_0_1"/>
    <dbReference type="OMA" id="YDIYRYM"/>
    <dbReference type="OrthoDB" id="21018at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="205"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME44843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="619" mass="69840" checksum="85D055771D5809B2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPK8</accession>
    <name>N1PPK8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C-terminal binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_61501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPK8"/>
    <dbReference type="STRING" id="675120.N1PPK8"/>
    <dbReference type="eggNOG" id="KOG0067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="OMA" id="RGVTVCN"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051638">
        <property type="entry name" value="CTBP_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029:SF7">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="7"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="59"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME44873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31907" checksum="3E24BF3C21E7BDB5" modified="2013-06-26" version="1">MVLKIGFTEEDVELFPNLKVIVRMGVGYDRLDRNALAKRKVVVCNVPDYGTAEIADHAIGLMLSMRRGILIHNEQQRATPPAPWMPLETPLVARLQGHTFGVFGLGRIGTAAALRAKAFGMNVLFYDPYLPNGVDKSLGIERTKDIKELFRRSQVLSLHSPCTRETRDMIGYGLLSLLPRGAVLVNTSRGEVLNLDGVERCLKEDILAGVALDVLPEEPIPEDRVHPLVQAYRNKESWLEGRMVLTCHTAFYSPESFVDIRIKSCETLRDVLIDGGKSNIITPEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPS9</accession>
    <name>N1PPS9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_72022</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPS9"/>
    <dbReference type="STRING" id="675120.N1PPS9"/>
    <dbReference type="eggNOG" id="KOG4701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007818_1_0_1"/>
    <dbReference type="OMA" id="CPQIGAD"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110002" description="chitinase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="30"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME44385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="377" mass="40884" checksum="AFECF4A2517BC580" modified="2013-06-26" version="1">MKFTTSIGALASAAVLSAHTAFAQRFNSAQNLGVYWGQNSYGASSGGLQQMNLSTYCQNANIDIIPMAFVVNITSSPGGQPQINFANSGYQCSVFPGTALWDCPTYTAEINQCQQTYGKTILLSIGGASYREGGFSSKAVAESEAQLIWNTFGPVNSSSNALRPFGTAVVDGFDLDLEDGSNYFRAFGLKLRALMNANTSKQFYLTAAPQCPYPDANLNPLLNDPNGAVPFDALFVQYYNNAGCDLRAYNTTTGATQKSFNFQTWSNYALSSASANKACKIFLGVPGNVGGAVSGSYRTAAQLKPIINYCKSFSNFGGVTVWDASQAYSNKPFLADTKTNLKAARTTRRDEFRHVHGHVKRHWTAERVVKRDQEKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPY8</accession>
    <name>N1PPY8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zygote-specific protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_115905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPY8"/>
    <dbReference type="STRING" id="675120.N1PPY8"/>
    <dbReference type="eggNOG" id="ENOG502S6ZF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166294_1_0_1"/>
    <dbReference type="OMA" id="CAAVIMA"/>
    <dbReference type="OrthoDB" id="10063670at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37475">
        <property type="entry name" value="ZYGOTE-SPECIFIC CLASS V COPY B GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37475:SF1">
        <property type="entry name" value="ZYGOTE-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="54" mass="5112" checksum="C30E4BDE401493F7" modified="2013-06-26" version="1" fragment="single">AGSAAYDICQTGCVGVVMACYGAAGFTWGATLGTTAPASLLACNAGYGACQAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPZ1</accession>
    <name>N1PPZ1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPZ1"/>
    <dbReference type="HOGENOM" id="CLU_2775905_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="69" mass="7507" checksum="12AA4BCE000FAA1A" modified="2013-06-26" version="1">MAHCSVCRRPSSRSAQNNSICCKPCLIMPAFPLRHTVTPPLALKITTLKNVPERPRASPVERNGSVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQC3</accession>
    <name>N1PQC3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_24621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQC3"/>
    <dbReference type="HOGENOM" id="CLU_900240_0_0_1"/>
    <dbReference type="OMA" id="TIKSTHH"/>
    <dbReference type="OrthoDB" id="3644217at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="309" mass="35492" checksum="C9453072514619F3" modified="2013-06-26" version="1">MSPTKRTTRRRAPAVTAAKPAATTIKSTHHEAKKQAKTVNVNAMFDPMKPRPKQRKEHDRRDVLKPAGIKKSPSRGIFKPFRRNKDEDLVSQLFDPDYFINCRKPRQVSPELPIEGFANLTTRYLEAQNDHLQDVHERHARSLAARRYGLPSSEDPEADGERPWIPRDEDIEAIDAQIVKLEMPLEDDIIQVQWREPNGAGTVRPQRLGDLIEKLTQRIAQRTVQIKELETERRKVAKEIEVLKADVQGESADTMKVSEKFEVQMQALQDEIGQLEKSTKAELEKLKREERAATKKLNDTLKEVMDTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQI8</accession>
    <name>N1PQI8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nucleoporin Nup133/Nup155-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_72222</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PQI8"/>
    <dbReference type="eggNOG" id="KOG4121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002493_0_0_1"/>
    <dbReference type="OMA" id="HVATLLW"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="147"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="690"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME44689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1419" mass="158389" checksum="F7DF5F1F10ED1B6B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSP8</accession>
    <name>N1PSP8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSP8"/>
    <dbReference type="HOGENOM" id="CLU_1938109_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="130" mass="14533" checksum="15FCF7B84C10C9BE" modified="2013-06-26" version="1">MAAVIRDVMPTQGSVERWQRNCSSSRRSCVLTMRKIVLLEGSKPTVNNRLLSQCDWAMDSVQILIPYPLHPLMDIGLEYFKIVINVLMFPLLQLASFSRCGGQLQLALAPDCIGEAGTRRNLVRVPVDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTR1</accession>
    <name>N1PTR1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTR1"/>
    <dbReference type="STRING" id="675120.N1PTR1"/>
    <dbReference type="eggNOG" id="ENOG502SJ55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030125_1_1_1"/>
    <dbReference type="OMA" id="LANWEFL"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF29">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="129"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="438" mass="49157" checksum="A58FCC4821348DEF" modified="2013-06-26" version="1">MFCLRGLPMMSIQQVHSKGIFHGLPVYSPELTGLTAIITGANGISGHYMLKVLSEDPKRWKRIICLSRRPPLIPGGLPDNVEHISLDFLKDPKEIASVLQTHKVVADHIFYYSYIQPTPKEGAGLWTNAEELVKVNCELLSNFLQALKLANVTPKRFMLQTGAKNYGGHLGPTKVPQEETDPRVELEPNFYYPQEDLLWKYCKENGVGWNIHMPGPITGCVPDASMNFAFALAVYASVCKKTSQPFAFPGDISSWQMPQSLSSAQMNAYQEEWGVLVGPPNQKYNTCDNSAFTWEAAWPKIAGWDGIEAQGPREGDVHTETESRFVPRGYGPKGITRRKFKLVDWAKEPEVQQAWVELMKEHDLTQGLEGLERVFAFLDGTLCRPAPLLMSMDKSRKLGWFGFVDSSEALLETFQDFVKLRMIPPVSKVTQTSIESDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTU5</accession>
    <name>N1PTU5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S15-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_70390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTU5"/>
    <dbReference type="STRING" id="675120.N1PTU5"/>
    <dbReference type="eggNOG" id="KOG2815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078264_0_0_1"/>
    <dbReference type="OMA" id="HLQEHRN"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME46368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42623" checksum="D2D1AC226009F6ED" modified="2013-06-26" version="1">MPPRIPIGQCLRAQTGSQCSQVSRAFSSTPSSQASTVAQKRKHRDPYAIVQAKARKAANLSRQEVLKKERAGTLGDPVRGIETPFVRSFDTAVPPELSPRTPSARISLSTLPAEDAPGAKTEHDSHLNFFLNKQELEHGVKRSRWLTQPLPEDKKTSIEDESGVDRSVSDGAESQNERTGLDDGSLFDSDTNDEIRKLLDNNTGPGSSDRPDWARSSSMLRDLTTESTPEAREKKLQEEHDIAKEALKRISSLSLGSSKDRLRVNTQRCVESFGRHNTDQTLPARPPSTAAADNQPEKFPRIGPDTGSSEVQIAILTAKIRALADGLALRGTPSDKMNKRNLRLLVHRRAKLMNYLRRKERGGPRWQNLVGTLGLTDGTWKGEISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTZ8</accession>
    <name>N1PTZ8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_70764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTZ8"/>
    <dbReference type="HOGENOM" id="CLU_640969_0_0_1"/>
    <dbReference type="OMA" id="ICARWSI"/>
    <dbReference type="OrthoDB" id="3642669at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="428" mass="48230" checksum="7EC1D138E337FE85" modified="2013-06-26" version="1">MKMDATRDNGSMRAPPLTGPVRTIGRSAPSDEDRSSMDREEHVPQRNCGEVKTGHHFIRNHPSIDLYPCHLRYMHVDLQEDVCGPRPKLVGDHISQLPAELLVQLLSHLPIPDLKRAERLSKHFRGTIKNPDNVNAFLQQRQYAARARLSRKIGHLTRRGFLDQQDGDLLDTFCAFVNRGGLTNDVSRCHYILAAMMDLFELNLRDLPSQIMEHTNKAELLSSLAAFVHFLFIAHIIKHVPCSELSCGICARWSIDGFMQGVASHCSRLERFGFTQDRALGWYQKLWNPMVPCGDDWADGILQAGPPLLNIVPEVEGPPRHLITHLWWHQGPNSANRWSATNLPVHRGLCSMAQLAAVVDVPSLPAKTNPRNNWGWGSMPLSHGLQTVYFFAYYMKSAWAYGLVQKALNGEGVDAFVLTAILEELNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU94</accession>
    <name>N1PU94_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU94"/>
    <dbReference type="HOGENOM" id="CLU_2793938_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="68" mass="7417" checksum="0C565F82DEC8F5DB" modified="2013-06-26" version="1">MAEDCSRHDRPADSSNVNVDVDVFHSPPTSDHEVSTTTSGRGHVNTINSSTLTGVSQDPPENYCDDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUT0</accession>
    <name>N1PUT0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUT0"/>
    <dbReference type="STRING" id="675120.N1PUT0"/>
    <dbReference type="eggNOG" id="KOG4497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024072_0_0_1"/>
    <dbReference type="OMA" id="TVWIWDL"/>
    <dbReference type="OrthoDB" id="308690at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="509" mass="55575" checksum="487FD7FFAEA101DF" modified="2013-06-26" version="1">MKRDLVRNAYLEKGRCRFSPATKFTSLKWSADSNQLLVTYDHGVHVIDTKVLEERVWLKNGTGGLGRVAAADFIGTDHLLVISEFGKAKLWHMNSAKALDLPDSKTTCDGSAWSSRPGKTSPGLFALLSRNGADDNLALHFPSINTASATIKLSTVDAQSLCWSPDGIWLAVVDLPTASPDLHIYTPDGHLFRSYPEGKDLEDGLGVKFITWSADGRCLALAKYDGKVELLNTKTFSPLAILEHNTTIDQSSLPQPEQAPVWQEVVPASNTHSYTLQPHPVSPPLSTNKTTSEPSELGVAELCFSSDGTYLATRDCRMLNTVWLWNMSTLAAHAVLIQHANVRSLTWHPSRPDTLMIDCAEGLAHVYRVSSSTPPLALLTGARSKARLSWIHTAAEAKSMIMATELNNFHIVYSEGQDETLSGTPKARAMAITRDAPFEEGGSDDSLFEVLSGRKPLPPKTAPSFTEMVDLDAEAEDTLAGSLEDTFREKKKGAEAQTEVDPLDDSEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV67</accession>
    <name>N1PV67_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV67"/>
    <dbReference type="HOGENOM" id="CLU_2372773_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="95" mass="10865" checksum="12691BD252B22D7F" modified="2013-06-26" version="1">MPERLKEPHFCGVGQAILIRAAHLVHIEFEAMRLPVPLPCFAVDAFRSVADLSKCRYKRARRRTDEEDGQHSHVVVVQGERDFVDVATKLGRKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVW9</accession>
    <name>N1PVW9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVW9"/>
    <dbReference type="STRING" id="675120.N1PVW9"/>
    <dbReference type="eggNOG" id="ENOG502SCHX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_3_1_1"/>
    <dbReference type="OMA" id="PWNPWLR"/>
    <dbReference type="OrthoDB" id="2567457at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21334" checksum="13B5890B260D8109" modified="2013-06-26" version="1">MGSRIPPRPREDLSEQEQKTYDEFTTIAEQGFGKNKEKFTYKDDRDAFVGPYALLTATPKVGKLAMELVYAIGELELPADVKETAILTCGGHFQAKYELYAHEAIATKSGVLTQQQVDAIKKDLRPGQLNENCSLAYDVTKRLCSRPGPLPQELWDSSIGAFGKEGTIALVHYVGFYAYLCIALNAVDVPVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWC7</accession>
    <name>N1PWC7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_69595</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWC7"/>
    <dbReference type="STRING" id="675120.N1PWC7"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_1_0_1"/>
    <dbReference type="OMA" id="TCCAITH"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="37"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="135"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="234"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME47692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="34688" checksum="F570AE5F79438C89" modified="2013-06-26" version="1">MSGTATAPPTSTGSAKLDSVKQNIEATADPKKLSGFALYSRFAFAGAVCCSVTHGGLTPVDVVKTRIQLDPATYNRGLIGGFRQVIQNEGAGALLTGVGPTFAGYFLQGAFKFGGYEFFKQQSINMFGYETASNNRTAVYLGSSALAEFFADIALCPLEATRIRMVSEPGFANGLFQGFGKIASQEGIGGFYSGFGPILFKQVPYTMAKFVVYEKVSEAAYANFFDKNNTSAGMQTVINLGSGLIAGFAAAIVSQPADTMLSKINKTKGLPGEGTTSRLIKIAKELGLRGSYSGIGARLFMVGTLTAGQFAIYGDIKKIIGAKGEVTIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWK2</accession>
    <name>N1PWK2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_22805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWK2"/>
    <dbReference type="HOGENOM" id="CLU_1731422_0_0_1"/>
    <dbReference type="OMA" id="SANAFWH"/>
    <dbReference type="OrthoDB" id="10469264at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="151" mass="16532" checksum="D88130CE64B838F1" modified="2013-06-26" version="1">MNFTDRRRKVMSHAWRCFDVVSKVNCETLAALAGFANAASANAFWHKIKVKLVPTPASGGRWGITSRPNGIASKQRGRLKVSKCTSKKPPKLEDAAFSTKPKIEAEEARSPMQSIPLESDSPNDRSGIFNHRDQPEAPATITSVSLPNNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWY2</accession>
    <name>N1PWY2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_85972</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWY2"/>
    <dbReference type="STRING" id="675120.N1PWY2"/>
    <dbReference type="eggNOG" id="KOG3153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044237_0_0_1"/>
    <dbReference type="OMA" id="HHLYMMT"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="8">
        <location>
            <begin position="177"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME47493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="254" mass="28389" checksum="5F7710090C46EF1A" modified="2013-06-26" version="1">MARLTMGLLQYSTSPDSTTALIILNSPIDDFRCFERLYDHASYVLCADGGANRLHDSLVAHYHEQRWPSALKKARPHAIHGDLDSVKDDVRKKYEDIGVQISYDPDQYSTDFGKAIKKVIEDLPHVEDIVVLGSVGGRVDQGIGLLHEIYREQKINHPNIRIWLVSEANISTLLRRGRTAISTPLGDGLITRNVGILPLYGKALITIEGFEWDVTDWPTEMGAQVSTSNHIMADQVIVTTNTEVLFTVERHTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX69</accession>
    <name>N1PX69_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX69"/>
    <dbReference type="HOGENOM" id="CLU_2427008_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="91" mass="10260" checksum="B24C52D97238D453" modified="2013-06-26" version="1">MCLVRETWAQCPSCLATWQLEELTRKVSTCPQGRPFGVQWARLCAQADVDHRSVPELCQRCRLAIDLASMSLSESKWSSAQHCRVVTLTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXL6</accession>
    <name>N1PXL6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 92 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_70018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXL6"/>
    <dbReference type="STRING" id="675120.N1PXL6"/>
    <dbReference type="eggNOG" id="ENOG502QU8M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_2_1_1"/>
    <dbReference type="OMA" id="DKWAYSF"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000001">
        <property type="entry name" value="Putative alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF43">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109672" evidence="1">
        <location>
            <begin position="24"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="38"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="343"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME48271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="828" mass="91364" checksum="860A1F447F765F65" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXR6</accession>
    <name>N1PXR6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_83991</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXR6"/>
    <dbReference type="STRING" id="675120.N1PXR6"/>
    <dbReference type="eggNOG" id="KOG0282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022571_0_1_1"/>
    <dbReference type="OMA" id="TLWHPHE"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000386">
        <property type="term" value="F:second spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000389">
        <property type="term" value="P:mRNA 3'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000348">
        <property type="term" value="P:mRNA branch site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="200"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="468"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME48321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="501" mass="55618" checksum="8EBA24E5CE524478" modified="2013-06-26" version="1">MSLVPARNGANGPPTRAADLVSDKQFRTSTKGKVPTGYAEEIAISEQSFRSLHREVQQSNAAGKKRKRETKGDSSVVYGAGAYKGPWAKYQERRIDSDSGEEVEVSDDGESGDEEVIYEEDAIAANPTRGSLAGTGYSEVSAEKETSTFEGSQRLDYQGRTYMHIPQDLDIDLTSDLENLSLKCYHPKKLVHTFKPASSKTAHEKALTSLKFFPSSGHLLLSAAADGKVKLWDVYHDRELLRSYNGHTKSVVDVDFTPDGSKFISASYDRQMKVWDTETGTCLGRYSTGSTPHVVRWQPDDPSGHEFLAGMHDNKIVQMDTRLPVDGEKKNPVQEYDHHLGPVNTITFTDENRRFITTSDDKSLRAWEYSIPVPIKFIADPEMFPMVKAASHPSKNSMIAQSSDNSIKVYNTGEKIKQNRKKEFRGHNNAGYAIDVAVAPDGGIVCSGDSGGFVCFWDWKSCKMWHKIKASDAAVLSVAWHPRESSKVVTGDLNGVIKYWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY15</accession>
    <name>N1PY15_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_69282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY15"/>
    <dbReference type="STRING" id="675120.N1PY15"/>
    <dbReference type="eggNOG" id="ENOG502RZ2S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006926_1_2_1"/>
    <dbReference type="OMA" id="EWHDELR"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME47290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="681" mass="75818" checksum="26900AAAF52782AA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY77</accession>
    <name>N1PY77_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_69191</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY77"/>
    <dbReference type="STRING" id="675120.N1PY77"/>
    <dbReference type="eggNOG" id="ENOG502QR6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013783_3_0_1"/>
    <dbReference type="OMA" id="SGWGTPW"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF39">
        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110316" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="19"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="231"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME47149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="628" mass="67801" checksum="E277769877D4409A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYZ7</accession>
    <name>N1PYZ7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_50862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYZ7"/>
    <dbReference type="HOGENOM" id="CLU_1061838_0_0_1"/>
    <dbReference type="OrthoDB" id="10687612at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="262" mass="28879" checksum="E4D3243F4BAF4443" modified="2013-06-26" version="1">MVQEHDGADSHSSTRKRSFTRPDSPGLHSPAPTQKTNLQGIPKKVARKYHVPGQGKLKDVDDVEAEEMSESDDDALAEVAACEAEEAVKHIRATRHAPEIIPERFSKITAVTRPESRRYAKVAESKQSKAEWQEEFTQKQDITLTQYEQLQGANQGARNPKYKLNKPRPAHFQALPARQRAPSPAARLPEQQERAAQPSAEDLDDQNVAGGLFNCDADIEIYLAQTKQTLRSNAVSLPQPISGTASTRQDDQKAPDDAVAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZW0</accession>
    <name>N1PZW0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_69637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZW0"/>
    <dbReference type="HOGENOM" id="CLU_2654479_0_0_1"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF5">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109728" evidence="6">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME47754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="76" mass="8475" checksum="EABD3A3200D14DAE" modified="2013-06-26" version="1">MRMNFFLILVPIYSDSLFLPTTIKGLGHTRVTAQLFNTPPNLIAFIPVLAFACTSDRNAMRGPPIVLDHFKPPCDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZX5</accession>
    <name>N1PZX5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_67940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZX5"/>
    <dbReference type="STRING" id="675120.N1PZX5"/>
    <dbReference type="eggNOG" id="KOG3092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034027_1_1_1"/>
    <dbReference type="OMA" id="QNGSPMA"/>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="441" mass="48204" checksum="367578DE0DDB8C36" modified="2013-06-26" version="1">MSSSSQAPESWISAFCSLVGHEYFAEVSEDFVEDDFNLTGLQSQVPMYKEALEMILDVEPEDASEEEEEEEEEDEEDEDEDEMQDGVRGGYRRAADAAAAAAERRHLRMASDLSVIESSAEMLYGLIHQRFITSRPGIQQMAEKYELGHFGHCPRVFCHGAKVLPVGCSDIPGQETVKLFCPSCLDVYSPPNSRFQTVDGAFFGTTFGCLFFMTFPELDIGGQKPAIQQLEPSVSASSPLSGSTAAQNSSIDKTSRGSLSSSLTSQQPNVLPPRLGDHTAVARQPDQINGVAPRNLAPGLGKGNVYEPRIYGFRVSEIAKTGPRMKWLRERPENVIDLDECAIWAQNQTAMMNDAAVAPAEAGFGDSEMADDNQEIDEGEVEDQDMDVSAAAAVRSNDQQVQEVTQRRKPSVKKQRHHQTGPGAMVNGDLARSVVRVGDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0B7</accession>
    <name>N1Q0B7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_69755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0B7"/>
    <dbReference type="STRING" id="675120.N1Q0B7"/>
    <dbReference type="eggNOG" id="KOG1518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026169_0_0_1"/>
    <dbReference type="OMA" id="VHANWRY"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000002">
        <property type="entry name" value="oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME47929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="441" mass="49808" checksum="91C9F7A0A18543AE" modified="2013-06-26" version="1">MNPIRPPTLEAALRSCTRSHRSPAYRNAVQSRSRAPQRRCIFESERPQRPGQLGSGDGPMPTKNQVWMPKTRIAVGVVFIGSLIYSMATGETDLPPPGSPEARPLPGQQLDAPTIAERDSLSKRESGVSVNSPMRLRMEQYIKQKQGEIVRALEDVDGKSFQVDQWDRPNGGGGISCVLQEGNVFEKAGVNISVVYGTLPRAAISKMRVNHKALDPDVESLEFFAAGLSLVLHPHNPMAPTVHLNYRYFETANADGSTNAWWFGGGTDLTPSYLFDEDVIHFHRTIKEACDAHDKTYYARFKKWCDDYFSVKHRSETRGVGGIFFDDLDETEKDAESLFAFCQSCLGAFLPSYLPIINKRKDMLYTEKEKQWQQLRRGRYVEFNLVHDRGTAFGLNTPGARIESILMSLPLTARWQYQHEPERGSREERLVSVLKKPVDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0D4</accession>
    <name>N1Q0D4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_68111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0D4"/>
    <dbReference type="STRING" id="675120.N1Q0D4"/>
    <dbReference type="eggNOG" id="KOG0854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_4_2_1"/>
    <dbReference type="OMA" id="HGPMNIP"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="5"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME49231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="225" mass="24699" checksum="1E6B646CB8DA5224" modified="2013-06-26" version="1">MAAALRLGSTAPNFDAETTAGPINFHDFIGDNWVILFSHPEDYTPVCTTELGAFAKLEPEFTKRGAKLIGLSANTIESHGGWIKDINEISGSNLRFPIIGDKERKVALAYDMIDHQDATNVDAKGIAFTIRSVFIIDPKKTIRLILSYPASTGRNTAEVLRVLDSLQTGDKHKVTTPINWVPGDDVIVHPSIKSPEAEKLFPKMQVVKPYLRFTPLPKSETSAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0E1</accession>
    <name>N1Q0E1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_120327</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0E1"/>
    <dbReference type="STRING" id="675120.N1Q0E1"/>
    <dbReference type="HOGENOM" id="CLU_2164339_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF41">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="111" mass="12046" checksum="9365E44B5E79595D" modified="2013-06-26" version="1" fragment="single">VFYIGTRSLEDVSIKGIILAVCLASYCVSKVATASQQLWPFGRDDDLSGYQWIIRVTSGWNNPLRSVLVSFVITFHLTVIHSGSTTALSAISPQGGVSVQSSYFKTISCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0L2</accession>
    <name>N1Q0L2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="18">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Phospholipid methyltransferase</fullName>
            <shortName evidence="18">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DOTSEDRAFT_84735</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 18">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 18">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Endoplasmic reticulum membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Mitochondrion membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="18"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0L2"/>
    <dbReference type="STRING" id="675120.N1Q0L2"/>
    <dbReference type="eggNOG" id="KOG4142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086119_0_0_1"/>
    <dbReference type="OMA" id="PTFWNIA"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000005">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="18">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="18">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="18">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="18">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="18">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00056845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EME49316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="203" mass="22035" checksum="9BDED856E6C352A8" modified="2013-06-26" version="1">MASLTDYVNVGEPSFLVAAACIVFNPTFWNIAARTEYSSKTITKLAGGNAYYGCYILAVTIFAIGLIRDALYERALRAQPSHPALLGFVSQGLAVGLVASGNTLVLSSMWALGITGTYLGDYFGILMDHIVTGFPFNVTGSPMYYGSFMSFLGTALWYGKPAGIVLSFLVLVVYQIALSFEDPFTAQIYAKREREQKAGKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1G6</accession>
    <name>N1Q1G6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1G6"/>
    <dbReference type="STRING" id="675120.N1Q1G6"/>
    <dbReference type="eggNOG" id="ENOG502RZTT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065416_1_0_1"/>
    <dbReference type="OMA" id="HDNACGP"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="52"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="284" mass="31373" checksum="9899211F6D1901D5" modified="2013-06-26" version="1">MARLDEHTGDDWGEMAKIYKKLTVGASSKPIRVILERLNALVPFSEATGILDDGTGPGPIISRIIEEYGTTIPNTCTLTATDFAPAMVDQVKNLKQEALQKNPESPWDRVSISVLDAMDLKGISDDSQSHVTAGWVFFMTPDPQKCLTESRRVLESGGVLGCSSWAGSQWMDLMKLASTIRSDKVVPELPKEWSSATAMKVEVEKAGFKDVTAEEVEVEMSFDRYEPLIDLLTTKMPHMINLLKEFSADEMQRLRGLMLARMKETVRSEPGVLHGTALIAVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q213</accession>
    <name>N1Q213_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_30967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q213"/>
    <dbReference type="HOGENOM" id="CLU_2015205_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME49801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="123" mass="13514" checksum="4E546002E9DD894F" modified="2013-06-26" version="1">MATSTKDGAAMAAHLEIHREPGIGKKSMLSKHSGSSPSARAVLPATFTLHKCTIVLEHGVPSDFCVDFRVLIASFVDGYWKWETMTPSSTKGYLPNVYVTLIMAYSHTKTVVLNEWLNINSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2F2</accession>
    <name>N1Q2F2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BD-FAE-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_67608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2F2"/>
    <dbReference type="STRING" id="675120.N1Q2F2"/>
    <dbReference type="eggNOG" id="ENOG502S3F0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_4_0_1"/>
    <dbReference type="OMA" id="DCVEFIR"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="295" mass="32308" checksum="4931C9C0A7F6F71C" modified="2013-06-26" version="1">MAAIKPTNDGIVFKTAGKLDIVLDLYVPENGKNLPILLWYHGGGLLQGHRSSLAPHMRNAVKKYNLAVISADYRLAPQATVQEILEDVQDCVEFIRTQLASQAGEGVLDTTRLAVSGSSAGGYLALLAGLYVEPKPDVIAPIYPITDPLGTFFTNPQPPPMGRPSVEREEVAEFLDPKAPQVANNPSDGARSKMYIRMMHDANLAELWSVPEGKEADKWRLSRQVYGRRAPPAYVLHGDGDTAVGVEQGDELVGAMLGCGIEVVYERPHGRDHFLDVGEDYGNDAFYQFLLKHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2N8</accession>
    <name>N1Q2N8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_164931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2N8"/>
    <dbReference type="STRING" id="675120.N1Q2N8"/>
    <dbReference type="eggNOG" id="ENOG502S2YX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039318_0_0_1"/>
    <dbReference type="OMA" id="EHVNPPF"/>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052469">
        <property type="entry name" value="MEIOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166:SF2">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="505" mass="55636" checksum="E94782354C98B71F" modified="2013-06-26" version="1">MGRSGKGDASIQQFFLPTPSTSPIKRAEPAVGDGFTAEEIRDALAPKHIEWQPDREYEDREINDLEPGPKAVTFMGRVANIFDVANTQKTPRSAKGCIKICVKDGVAAITVRIWYASRVPNLRLGSLVTIWTNHISNGENGTLSNSNAPLFASLFPERDRNCHMMIHDNSDPGMYKTPIAYRPSLPLDGLMTLQNFIDGGYDVTDAKILVVVKSIGAKKRITRKDESVTENISLHVHDDTAEAVLGLWGTSAFSPFSSDTSGDKTDSEAAYTSRGWKAGETVLLVQGPGWKIGSKTYLNLTAASIVDVDPSLPDAEWLRRWSTRQRSREAINPSFPEDIFDFDAVTTGPVRCLFTLADLDEFARCAPDETFQGYLSLLILESNLFRLYKSGTLLSGECCNIPVHANSLSARCKGCDQELCLRLNQKLLGQLIDETGVIASGRLLFCDSAWRELLGRGPEDLLKLDDNEVKCLSDRLLFCRITVIFGWTGDETKAGGRICVMGVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2U5</accession>
    <name>N1Q2U5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_67753</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2U5"/>
    <dbReference type="STRING" id="675120.N1Q2U5"/>
    <dbReference type="eggNOG" id="KOG1720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017787_1_1_1"/>
    <dbReference type="OMA" id="KFERVDM"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120105">
        <property type="term" value="C:mitotic actomyosin contractile ring, intermediate layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071958">
        <property type="term" value="C:new mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030869">
        <property type="term" value="C:RENT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140013">
        <property type="term" value="P:meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051229">
        <property type="term" value="P:meiotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044878">
        <property type="term" value="P:mitotic cytokinesis checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016479">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031536">
        <property type="term" value="P:positive regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903501">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140429">
        <property type="term" value="P:positive regulation of mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902846">
        <property type="term" value="P:positive regulation of mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031031">
        <property type="term" value="P:positive regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070550">
        <property type="term" value="P:rDNA chromatin condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="253"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="322"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="413"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="535"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME48804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="654" mass="72423" checksum="8FA7991CE1CECDD2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q341</accession>
    <name>N1Q341_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_76390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q341"/>
    <dbReference type="STRING" id="675120.N1Q341"/>
    <dbReference type="eggNOG" id="ENOG502R1CD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_566225_0_0_1"/>
    <dbReference type="OMA" id="WANTFNP"/>
    <dbReference type="OrthoDB" id="3650696at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="482" mass="46578" checksum="44ABDE908B7E70D7" modified="2013-06-26" version="1">MAGINIGGLHAGVGGDGADVSINGHDVGVGWNGNGGNVQGNGGAGISINGHGVGDGVDGNAGVGSNAGSTHGAYVGESPDGQAQVAAGSSDADSAGSASANTDTSSQGQVDAQQPAGPPPAANGAAGQASGQGQVNPRPPPPAAPAGTGAGQGVGVGAGAGAGVGAGLGIGSDQPLAPLPNHGSGVACTIQGGPARLLYLPPSDAGRDNSPTSAIGATTSTGAGVIPTPAAGGLPPKNQPVTAWANTFNPDYCYISFSTLYATSSGSTVGPTFSNALIPFKTAEISTICASQPTGAAGDAERDATQFSLAGLSMTGDNNTGCFHIVAPPRIGKFIPSWDNGLYWNVSFQQPQVILPEGGAQNPPADCAVCATPAFSPPAGTAYPTMVNEGYPQEYSPATETAPPGVSAASYGQFTATRPDLASPTITGSPTSPFGSIGSNVSIANTSSSQPTMYTGEAALAGVSGGKFGIFVALVPLLLALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3A8</accession>
    <name>N1Q3A8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_165386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3A8"/>
    <dbReference type="STRING" id="675120.N1Q3A8"/>
    <dbReference type="eggNOG" id="KOG1099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_1_0_1"/>
    <dbReference type="OMA" id="FIVCLNF"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106339">
        <property type="term" value="F:tRNA (cytidine(32)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002130">
        <property type="term" value="P:wobble position ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="114"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME50276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="380" mass="41824" checksum="8766374526874C62" modified="2013-06-26" version="1">MGKSSKDKRDAYYRLAKEQGWRARSAFKLLQLDEEFNLFEGVTRVVDLCAAPGSWSQVLSRILIKGERIGRAAWEDKRYKELLRLREEEQPPVEGQPESESEDGAVEPPAVAARTDVKIVAIDLQPMSPLDGITCLKADITHPSTIPLLLKALDPSYERDSSSIEASHPVDLVISDGAPDVTGLHDLDIYVQSQLLWAALNLALCVLKPGGRFVAKIFRGKDVDLLYAQLKVVFERVTVAKPRSSRASSVEAFIVCTNFRPPAGFRASLDNPLGTTRQLEADKERLKDGVKPGRIAREDGITELSLGMELDDVDHNRWIAPFLACGDLSSYDADASHKLPEGHISLDPVQPPTAPPYRAALEERKKMGGAYGKTKLGAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3G7</accession>
    <name>N1Q3G7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_68074</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3G7"/>
    <dbReference type="STRING" id="675120.N1Q3G7"/>
    <dbReference type="eggNOG" id="KOG1650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_10_0_1"/>
    <dbReference type="OMA" id="QVKVERW"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="8">
        <location>
            <begin position="62"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME49200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="883" mass="94992" checksum="C764519354EE4D0D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3H7</accession>
    <name>N1Q3H7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycosyltransferase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_68528</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3H7"/>
    <dbReference type="STRING" id="675120.N1Q3H7"/>
    <dbReference type="eggNOG" id="ENOG502QQ16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040188_0_0_1"/>
    <dbReference type="OMA" id="WHMEHEA"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME49778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="530" mass="61344" checksum="5B578E948627C092" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3M5</accession>
    <name>N1Q3M5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_68132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3M5"/>
    <dbReference type="STRING" id="675120.N1Q3M5"/>
    <dbReference type="eggNOG" id="ENOG502QR7H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059964_3_0_1"/>
    <dbReference type="OMA" id="WNRVDDY"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME49260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="266" mass="28516" checksum="62F2A4F78B7B84C0" modified="2013-06-26" version="1">MQTANRLQKALKSGKASFGGWQMLPGANLSRTIARTPNLDWICIDCEHGNISDDAMHDSVAAVAACGVSPVVRVADGQHWMIKRALDAGAHGIIVPLLQSAQDARNVVKFSKFPPQGNRGLGSPFSMEKFSEPGANAKELSLMEYYRQANDSIVVIVQIETASALEQIKEIAAVDGIDVCFIGPVDLGNSIGHPVESINKFPPQLEEAVQTMHEATQDAGKYTAIYTVGGESAKRYADQGFNMINIMNDVAAIKLAFGQAVETASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3R0</accession>
    <name>N1Q3R0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_68164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3R0"/>
    <dbReference type="STRING" id="675120.N1Q3R0"/>
    <dbReference type="eggNOG" id="KOG1487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="OMA" id="SAKHPGQ"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="65"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="291"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME49300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40232" checksum="7CEAD2DEF6D785D3" modified="2013-06-26" version="1">MATTVDKIKGIEEEMAKTQKNKATSFHLGQLKAKLAKLKKELLTPSSGGGGGAGVGFDVARTGVASVGFIGFPSVGKSTLMSRLTGQHSEAAAYEFTTLTTVPGQVVYNGAKIQMLDLPGIIQGAKDGKGRGRQVIAVAKTCHLIFIVLDVNKPLTDKRVIETELEGFGIRVNKQPPNIKITKKDKGGISITSTVALTHIDSDEVKAVMNEYRMANCDIAIRCDATVDDLIDVIEAKSRAYIPVIYALNKIDAISIEELDLLYRIPNACPISSEHGWNVDELMEQMWEKLNLRRVYTKPKGKLPDYSAPVVLRSTACTVEDFCNAIHKTIVDQFKIAIVYGRSVKHQPQRVGLSHELADEDILTIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3X8</accession>
    <name>N1Q3X8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="3 9">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_69066</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3 9"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3X8"/>
    <dbReference type="STRING" id="675120.N1Q3X8"/>
    <dbReference type="eggNOG" id="KOG2944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_0_1_1"/>
    <dbReference type="OMA" id="MGDAWGH"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="8"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="167"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME50412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="322" mass="36794" checksum="BA616F48AD08E3E3" modified="2013-06-26" version="1">MTDTSKYKFNHTMLRVKDPQASIKFYEHLGMSQVNKFSFPDNKFDLYFLAYDSPGAASHGNHWTDREGIIELTHNYGTENDSNFKVANGNKEPGKGFGHVCVSVDNIQAACARLEDAGYKFQKKLKDGRMHHIAFALDPDEYWVEIIAQNPVDKTEDVKTTDLKTYRMNHTMIRVKDKDISIKFYEDVMGMNLKRTSESKEAGFNLYFLGYGPKPSSDDSANGVNPTADREGLLELTWNYGTEKEEGKIYHDGNSEPQGFGHICVSVDDLDAACKRFEEKNVQWKKRLTDGRMKNVAFVLDPDGYWIEVIQNEKYKDAPGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4P2</accession>
    <name>N1Q4P2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4P2"/>
    <dbReference type="eggNOG" id="ENOG502SK7F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027663_1_1_1"/>
    <dbReference type="OMA" id="IGHVRHD"/>
    <dbReference type="OrthoDB" id="5376312at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="491" mass="54192" checksum="EBEC1C6D68332F45" modified="2013-06-26" version="1">MLLPNDAATRDLLGKRQQQGSGNGGGSGSPVVVVVVVTLVVVILVSVLAWYLLRKVRKKHENPRYLPTQFLKRKWQNWKPWSSQSSKGTYSRASDVPTLHLRSDNRSRQDLPDLERTHAAEAAETGDGVERHTSVRSVMTLPAYSRSVRENERVLAREGERDGIDVVVELPENEDEEEARREEEMESLYLIRLQRRTEIAEREERRQRRREARQRGDFAEVERIRQESAAANQARETQGATAMIAEHQGRNRDTRVSSVSYAALGVARHDGTRIRSDSANSDSRPLLDSAASMSGGASLRPWPTRDSHSFTHHRNQSQADSIMSLSDNSSEMVDMSDMPPFGRAGSDFEIVALNGSHSRNGSAAHTPSGGRSRASTNTGPVRPSIDTTAIGVGVSGDLGEGQIPNVEPPSYDDDGFEEAPPYTSPTQEPVPQTQLQSMSVATADRPESERSPSDNNAPRLPEIGRLPSIRIAEATPIDPRRSAFPETVREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q521</accession>
    <name>N1Q521_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_68815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q521"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OMA" id="AWCNGSI"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME50080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="52679" checksum="BD59F21C671BF6AC" modified="2013-06-26" version="1">MSASRESHDNKDVNKGLDISTPTQDSNRSTASDDVAPEQEKDSHIQRPEALTQAPNGGYGWVCTACCALINAHTWGLNSSYGVFLAHYLRTNTFPGATYLEFAFVGGLSISMAMLVSPVATLTTRHYGTKTTLFIGVILEAGSLIGASFAYKIWQLFLSQGVCFGFGMGFLFVGSVGIPPQWFTTRRSLANGISAAGSGLGGLIYSLGAGAMIDSVGLAWTFRILGIVAFVVNSICAMLLKDRNKIIGSSQNAFDAALFKRTEYLLLCAYGWFSMLGYVVLIFSLANYANSIGLGSSQAALVSALLNLGQGLGRPPIGYFSDSIGRLNMAGMMTALCAIFVFAIWIPAKNLGVLIFFAIAGGAVAGTFWATIAPVAAEITGLKHVPSALNLIWLVIVLPVTFSEPIALEIVGGTGSYIGAQLFVGFMYIAAAVCLLFLRGWKIGEVDEVARLKGQRADDVDAVAVENDEDVAQTARVAGRRRITTDFWKWRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5A6</accession>
    <name>N1Q5A6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_20500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5A6"/>
    <dbReference type="STRING" id="675120.N1Q5A6"/>
    <dbReference type="eggNOG" id="ENOG502SBD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034681_0_0_1"/>
    <dbReference type="OMA" id="HRTQLRM"/>
    <dbReference type="OrthoDB" id="5360255at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004354">
        <property type="entry name" value="Meiotic_Rec114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03525">
        <property type="entry name" value="Meiotic_rec114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="594" mass="65584" checksum="7CC69BF9448EBBDD" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5C2</accession>
    <name>N1Q5C2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable lysine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_77245</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5C2"/>
    <dbReference type="STRING" id="675120.N1Q5C2"/>
    <dbReference type="eggNOG" id="KOG1885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_1"/>
    <dbReference type="OMA" id="DFRNEGM"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="274"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="42"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME50159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="627" mass="71177" checksum="94203DA19F9687FA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5I3</accession>
    <name>N1Q5I3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_69050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5I3"/>
    <dbReference type="STRING" id="675120.N1Q5I3"/>
    <dbReference type="eggNOG" id="ENOG502SJ74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031471_0_0_1"/>
    <dbReference type="OMA" id="RWHWINQ"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109913" description="Cytochrome b561 domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="210"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="461"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME50394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="496" mass="54432" checksum="C735154591FDCE94" modified="2013-06-26" version="1">MILRTFFFVFLALLGLVFAADTEEGLAAGIDDNAKAAYFVLPSAGYVFALNVAANGDVYYHMNAPAQSSWMGVGFGKDMSNTRMLIAYIGENGHNLTNTARIATGHSEPEWESDIVIDNIHTDAYAPFSNTLSPDGIMIAHAVCRNCSSWIGGSIDVNNEQQPFIYALGPNITLRSDDKNAPLRVHASYGTFNLDMTVATSNTSYGRVPAPQDPGLQVGDSFWAFANYFSSAAYNLGTLADWAPAAHAVFMCIAFLLIFPLGAISLRLIRRAFVHATAQMIGIVFVVIGLGLGIYASSLYNKSKHYNTYHQIVGLLVFAALFLQMGLGLAHHLVFMRSGVPTIIGKIHRFLGISIMLLAVVNCGLGFQFSGRSSTAYAAVVAVMVVILGGLTLLVWRYNRQHMYKPEKEPYSVPNYSDRPGEYEMRSAPFAPIDNVYTPRTPHFAAPKLDDPENYRQHLMRSNTSNTLGQDSMYTDTPASDRENPFKAKWEAMPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5I4</accession>
    <name>N1Q5I4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_69055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5I4"/>
    <dbReference type="STRING" id="675120.N1Q5I4"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="OMA" id="APMSELW"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="72"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME50399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="640" mass="70516" checksum="874A9528627CD26F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJ47</accession>
    <name>M2WJ47_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_75631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJ47"/>
    <dbReference type="HOGENOM" id="CLU_2622005_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="78" mass="8779" checksum="C1476330EC5091B1" modified="2013-05-01" version="1">MPQLMMLHRQSRVPQRSLERLCSRSMVWRVAEIFSHIKQLEARRRIRERCAPVCCATSDVKLTQCGGAGVDSGTSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2WK15</accession>
    <name>M2WK15_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_159521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WK15"/>
    <dbReference type="STRING" id="675120.M2WK15"/>
    <dbReference type="eggNOG" id="KOG0814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1081926_0_0_1"/>
    <dbReference type="OMA" id="AGVQRMF"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28570" checksum="03BC9FFC24792EA7" modified="2013-05-01" version="1">MQQEPPIAALRPDPEPHVHTFFETSTGTWQYVVADPITKNAVIIDGVLDKVHSSKGIRTTAADRLLGHVRQHGYRVTRILETHAIRDQQIRTAAWYLRNQLRDERGHLPRICTGKSIAGVQRMFARQYRQNPEWANHFDSTFRHGEVFNIGELSCKVLHLSTDTFAFVIGHNVIIGDVPGEQAMPRLAGLTKGYTWHPGGGDASRPRTATTTSSNWPTPQPSPSLPAQSYSPLSPTHVPRPSGNDGRPASDIYEMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2WK39</accession>
    <name>M2WK39_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 17 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_75134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WK39"/>
    <dbReference type="STRING" id="675120.M2WK39"/>
    <dbReference type="eggNOG" id="ENOG502SI3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028820_1_0_1"/>
    <dbReference type="OMA" id="GQYEYPH"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012677890" evidence="5">
        <location>
            <begin position="16"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="6">
        <location>
            <begin position="425"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME39308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="576" mass="59618" checksum="43F69620A1948D58" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2WKQ1</accession>
    <name>M2WKQ1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mox4</name>
        <name evidence="7" type="ORF">DOTSEDRAFT_159919</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WKQ1"/>
    <dbReference type="STRING" id="675120.M2WKQ1"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="OMA" id="QRHDFHM"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF238">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME39558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="419" mass="46924" checksum="1A0C56C2E897A7FD" modified="2013-05-01" version="1">MAGLSAAVACALAGHHVVVLESARELAEIGAGFQVTPNGCKVLQQYGILEELRRTAAEPTLLQVRRWSDGRVLSRTDDFNVEMKTKYNAPFWDLHRVDVQRALATRANDLGVEVRLGSRIEDIDFEKTTLRLASGETLKADLIVGADGLWSKCRQRFLVSKGLEEDAPIPTGDLAYRIVLNVDAVKSREVKDWIVQPTCQFWIGPEAHVVAYSIRKGEMINIVLLVPDNLPPDVSKQSGSLEEMRAIFGQWDPMLNRFLDEVESVEKWRLMHRAELDSWISPKSNFVFVGDACHSMLPYLAQGANSAIEDGAVLGNILSAIESQSQLPAALELYEQLRKKRGEAIVRETFAQRKAFHMPDGDEQAKRDELMLSKLGKHIDCKFPSRWQCPEVQPWLYGYDAKDEVERALGAQPLTQISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2XI21</accession>
    <name>M2XI21_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_75018</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XI21"/>
    <dbReference type="STRING" id="675120.M2XI21"/>
    <dbReference type="eggNOG" id="KOG2468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007859_0_0_1"/>
    <dbReference type="OMA" id="HGTMVAM"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="678"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="722"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME39117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="942" mass="103751" checksum="23685333A161422B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2XJJ1</accession>
    <name>M2XJJ1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_56948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XJJ1"/>
    <dbReference type="STRING" id="675120.M2XJJ1"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012774_2_0_1"/>
    <dbReference type="OMA" id="TEVIANF"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="222"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="629"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME39627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="91272" checksum="C74D813744F5FD79" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2XL88</accession>
    <name>M2XL88_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_35547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XL88"/>
    <dbReference type="eggNOG" id="ENOG502RGQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1326348_0_0_1"/>
    <dbReference type="OMA" id="EDTFAPM"/>
    <dbReference type="OrthoDB" id="3650560at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="207" mass="21813" checksum="40F0D1C39A282300" modified="2013-05-01" version="1">MYYKCTHADLRAADDDSKPSGSAISQHIAKLKKGSGPNSGLGAASKGTQIKSTPPAKRAALPKTPSSSAKRARTSRMSDEDDSDDENILSFAAIGKRETPARRSSGLRKSYCDKSAEEEEDDGAETCEETATGQAAAASALGSSASDNIEVAAAQAAPRDSVQADDVDDLFGRPRKESTARSKSNPPKFDYFNNAAESDEDTFAPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y5C1</accession>
    <name>M2Y5C1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_45362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y5C1"/>
    <dbReference type="HOGENOM" id="CLU_2320341_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="99" mass="11116" checksum="0FCDDCA85105E58E" modified="2013-05-01" version="1">MYSAERPRVRWCGVRDCSSICSQSVSEESRMCLAHMRGRSTDLLCMHVKSLTAGSWGCLQWEISVLLPYGATALILARMYAMVIQAKTHVDNSMCVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y5I1</accession>
    <name>M2Y5I1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_63702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y5I1"/>
    <dbReference type="STRING" id="675120.M2Y5I1"/>
    <dbReference type="eggNOG" id="KOG2971">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048373_2_1_1"/>
    <dbReference type="OMA" id="YRHRHLM"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000464">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000465">
        <property type="term" value="P:exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000009">
        <property type="entry name" value="Ribosome biogenesis protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="29"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="315" mass="35508" checksum="E7917CAAFA3CC825" modified="2013-05-01" version="1">MASVYKQVAKQPNGKSKDNSDEVKPKNKQRVLILSSRGVTYRHRHLLSDLNSLLPHSRKDAKLDTKTQLHQLNELADLYNCNNVMFFEARKGKDLYIWLSKPPNGPTVKMHCQNVHTMEELNFTGNCLKGSRPILSFDAAFEKQAHTRVIKELLTHTFGVPQTSRKIKPFVDHVMGFTLADGKIWIRCYQITETEASKKKEGEDSAATDATAPQSTVEKSGKGETHASLVEIGPRLVLTPIVILEGSFGGPVIYENKEFVSPNQIRSDLRKSKAGRYNRRAEATIERKAKKRDMGLRTGEGTRDVDELDDRMVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M2YHT3</accession>
    <name>M2YHT3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_29683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YHT3"/>
    <dbReference type="HOGENOM" id="CLU_1896161_0_0_1"/>
    <dbReference type="OrthoDB" id="10647865at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="134" mass="14914" checksum="9D736491CEC8C3AE" modified="2013-05-01" version="1">MLLGDDQVGFSPLAGLRQQYGLRIQIIYHDNSATPELQAVLETFELPVPAASRRSRRDDCWDALLVAKEDGALPEYVVLFLRINPASARRDLDSPPRDAVERHIESGVNYEDGRIGRSARRKKVGGYFPSSTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIN4</accession>
    <name>M2YIN4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tim44-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_160418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIN4"/>
    <dbReference type="STRING" id="675120.M2YIN4"/>
    <dbReference type="eggNOG" id="ENOG502SAX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055139_1_0_1"/>
    <dbReference type="OMA" id="QYCKREN"/>
    <dbReference type="OrthoDB" id="19619at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024621">
        <property type="entry name" value="Mba1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07961">
        <property type="entry name" value="MBA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME38771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28845" checksum="5797FFF2D695435C" modified="2013-05-01" version="1">MGFLPNTFVPPSGKNLPSWFSNPRDRWKILTLKGWNWYYYLAGHFMAFWMVKPRVKLERGQLPRISKKLYEDMYSNFATGNLQAIENILSPGMLGSLRARIAQRTPNTGLKWTVHKYLTTPKVISYKFQVLPDGPNTDKFAFAQAVVRIQSLQSLTKTKRMRVVDRESNKACIKEATVDEQGSFVHDGDLKSYRQRVARVTTEYLVVQRMVRHSRLGEWHVWGTTEEATMREIRGKGRQDEDELMNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIX1</accession>
    <name>M2YIX1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_48331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIX1"/>
    <dbReference type="STRING" id="675120.M2YIX1"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_1_4_1"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME38831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26533" checksum="729953A467E8CBC5" modified="2013-05-01" version="1">MALIGGVTWTRAGLVFIAQLLGSMAAAGIVQALFPGPMAVSTTLGGDTSIVRGLFIEMFLTAELVFTIFMLAAEKHKGTFIAPIGIGLALFVAELTGVYFTGGSLNPARSFGPCVVLRNFTGYHWIYWLGPALGALVAVGFYRFVKMLEYETANPGAEFNEHEQEIFEENHDEDNAATGADVARPNPATVNSDPDFRSSSAQAPMASIQSRTRMDGNSSEKFEEVPYHPGQGPYHAGPQAENGGMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJ42</accession>
    <name>M2YJ42_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_39127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJ42"/>
    <dbReference type="HOGENOM" id="CLU_1825237_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="141" mass="15477" checksum="3BC9D3044878AD47" modified="2013-05-01" version="1">MQSIKDRLFSVKASETKLKVPPGVPTSPPGTDPTKTRKIEAQYLPNISILQYASDSGLFGEQARKSMLEEDSSLYRRSLSLNFAFGLTALVRRLFMSAKGHHGSTPTTADVCTERKMINALNTPPGLLLLAVPTSNENRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2YL73</accession>
    <name>M2YL73_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="3 11">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_75314</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 11"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YL73"/>
    <dbReference type="STRING" id="675120.M2YL73"/>
    <dbReference type="eggNOG" id="KOG0366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_3_0_1"/>
    <dbReference type="OMA" id="VKRCQCP"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000012">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="12">
        <location>
            <begin position="25"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME39620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="350" mass="37898" checksum="983A7D52223ECECF" modified="2013-05-01" version="1">MSLAAGPGRGGGAASGTLPEELQLVVEKHVSYIQSLDSRRDELEYHLTEHLRVSGVYWGLTALHLLGHPEALPRVGLLNFVFSCLHESGGFGASPGHDPHMLFTCSAVQILAMVDGLDELDKRLSNGRGKVAKFIADLQQPNGTFAGDKWGETDSRFLFCALLALSLLHRLPRQKPDEPPSIDLKAAMDFIKSCQNFDGAFGIAPGAESHSGQVYTCVGALMLGGELDSFLGEDGKDRLGGWLSERQLASGGLNGRPEKLVDVCYSWWVLTSMAMIDRIHWIDGEKLARFILSAQDPDQGGIADRPGDMVDVFHTVFGIAGLSLLGYPGLKPVDPTYCMPKDIVDQVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2YL88</accession>
    <name>M2YL88_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_75386</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YL88"/>
    <dbReference type="eggNOG" id="ENOG502S3SQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526777_0_0_1"/>
    <dbReference type="OMA" id="FNITRWN"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF15">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004030307" description="Heme haloperoxidase family profile domain-containing protein" evidence="9">
        <location>
            <begin position="18"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="10">
        <location>
            <begin position="157"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME39721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="517" mass="54887" checksum="5F8166CB6196611D" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLD5</accession>
    <name>M2YLD5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_75355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLD5"/>
    <dbReference type="STRING" id="675120.M2YLD5"/>
    <dbReference type="eggNOG" id="KOG0908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072377_0_0_1"/>
    <dbReference type="OMA" id="PIFEMFP"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="5">
        <location>
            <begin position="132"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME39680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36067" checksum="1D06C4045FBF0CF8" modified="2013-05-01" version="1">MSKTVHVDSPTHFSGILSSSRIVVADFYADWCGPCKAIAPVYEALSNQLSRPGQITFTKINTDEQKDIARTYNISAMPTFVIFKAQREVKRVRGADPKGLDAAVKQLAEEAGRADEGGADAGEGSSSSGKWTGAAAPRGYPEITEEVEIKGLDFLNLDGEVGDKRTIFTPEQPSSLNAKGKSAEGKKDWIESDTDEQLMLFIPFQGTLKLHSLHITSFPPADDNDVMRPKTLHLYSNRSHVLGFDEADDTPATQTIEIKEDHWDAKTQTAKVELRFVKFQNISSLTVFVADGEGDGEKTRIDRLRLFGESGVKREMGKLEKIGDEQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2YM26</accession>
    <name>M2YM26_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_153162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YM26"/>
    <dbReference type="STRING" id="675120.M2YM26"/>
    <dbReference type="HOGENOM" id="CLU_090039_0_0_1"/>
    <dbReference type="OMA" id="GIAFCEI"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="266" mass="29398" checksum="3C326648127B5B51" modified="2013-05-01" version="1">MVRYALMGATGATGTAILRHLLQEPANDQNVNVYVRSKAKLLDKFPDLETQAPFPTKIYEGSNTDRTVLKQCLHDVDVICMCIATNVSTPGESRFTDTANAVTDALLDLKKEQASSYKTPSILILRASILNPTFSPARKGYFESFLMYCLHHLYNNMNAANEIYEAKARETPGLLNIIYVDPPGIHDNDGTNPTGYELLLAPPADRTPVFNLSYADLGIAFCEIARRREEFNGKGVGVFGTGEIKLTWPILMGHLSQGLRGRVLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2YMB8</accession>
    <name>M2YMB8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Swi5-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_132200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YMB8"/>
    <dbReference type="STRING" id="675120.M2YMB8"/>
    <dbReference type="eggNOG" id="ENOG502SBQH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126161_0_0_1"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010772">
        <property type="term" value="P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME43146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18143" checksum="837061517005812E" modified="2013-05-01" version="1">MSSQELPHQQQAQETDTEPPSFDFPLPSSPSQRKSDEVNKATTSHSDNTTTQDPQISNPRRLALSAKRNNLEAKLADLQSQRQALIAEAKLPSGLEMPEDWSDEQRSKQAMVDANATIKEHIALLHTYNEIKDIGMGLMGLLAEKRQARVATVMEEFGMGEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2YP62</accession>
    <name>M2YP62_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_132336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YP62"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="IVPMVMW"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="31"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME43401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="477" mass="52521" checksum="8B493B7082FFFAD9" modified="2013-05-01" version="1">MPAKEFEETELIEAADPSKQKALVRKLDLHIIPTVVIIYTLAFLDRVNIGNAKLLGMEKDLDLKGNQYQVAVSMLFVTYVLFETPSNLVLKRLKPNIFLPSIAVAWGIVATCTAAVQSYTGLIVCRLLMGFFEAGLCPGIVVYLTMFYTRRQLALRIATFLAGAALAGAVGGLIAYGVKDLDGVRGLSAWRWLMVLEGCPSIAMGLVAYFTLAEKPSNARYLTPSDRDLLILVRQAEVGQTASAQEFSWKDVREGVKDWQIWVLCIANFSDNIMLNGMATFLPSIIKNIGHWNAAESNALTVPVYALGIMTYLSGAYISDRLQIRGPIAVGMGIICVAGYCMLISHTSSAVSYAGCFVVIFGMYLTSGLTLTWIAGNKPRWGKRAFATGILLSFGNCAGIVMPFLYPNGDAPEYTMGFAVSIACVSTAIVMWIGMSMYYRWVNKRRSEGREDWKLEGKTEAEIEEMGDKSPRFVYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBV5</accession>
    <name>N1PBV5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBV5"/>
    <dbReference type="HOGENOM" id="CLU_2359703_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="96" mass="10606" checksum="2989B0D4A83B63F0" modified="2013-06-26" version="1">MRLSQNNTYEGHTGFLAPSVGTEALLDGGRLPSTTGFDWADLLLNVSHPVGLRKLSSLEPCKLRAVWQYLPSTRKQRCAEGRAVTITWTCRSVPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC00</accession>
    <name>N1PC00_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_57415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC00"/>
    <dbReference type="eggNOG" id="ENOG502RXM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067132_0_0_1"/>
    <dbReference type="OMA" id="NKAADFG"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="126"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME38273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="281" mass="30955" checksum="D43801B49068A4C2" modified="2013-06-26" version="1">MSAIGADLPPHLLAKRKRQQEEEEQSATTTSSGAKRSASPDEPEKRRRVIGPAMPPTPLDEIPERPPKPQVDDSSDDDDDFGPALPTGSAVTSALNEDEERGIQAGGTTGSHPEEKLKRDDWMMMPPKQDDLAARLDPTKQRPTKFNTGKGARGQNNMDSDSSTWHETPEQKQKRLQDEILGISKPSPIPNTTTGKTSKLTREDATNRKVKEQLETMTRATSLLEQHQKSKGAEAEDDPSKRAFDREKDMASSSRISSSQKRQMLNKASDFSGKFSGGSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCG9</accession>
    <name>N1PCG9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_181752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCG9"/>
    <dbReference type="STRING" id="675120.N1PCG9"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OMA" id="IVGMLCT"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF111">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_1G10100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME38533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="302" mass="32527" checksum="2CD9B6D743884D77" modified="2013-06-26" version="1">MSRPDYSRGSSSTNIARSGTQRVLEGKIAIVTGASRGIGAAICENLASKGCHLIMNYTSDNSKDKTEQLAQELQQTHRIQTLPVQADLGAETGPAHIVNIALNHFAHPKTRKLQIDIVINNAGVANKKTIEEYTSEDFSWLYNINVRGPLLLIKAAQPYLPYDRSGRVVNLSSVSSSLGFEGDAIYGGTKAALEAMTRSWARELSERCTVNAVNPGPVATDMYAGTSDEFQAKMAGWTSNTPLAKIRPDVDRKDLVEKAKIAGGRPGYDHEVAGVVAMLCTPDSAWCTGSVICANGGFKFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCP1</accession>
    <name>N1PCP1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_66113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCP1"/>
    <dbReference type="STRING" id="675120.N1PCP1"/>
    <dbReference type="eggNOG" id="KOG3731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_4_0_1"/>
    <dbReference type="OMA" id="WCHGEHE"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000051">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME40308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="580" mass="65230" checksum="ED65BB59EEB23682" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCZ7</accession>
    <name>N1PCZ7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_177455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCZ7"/>
    <dbReference type="STRING" id="675120.N1PCZ7"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700248_0_0_1"/>
    <dbReference type="OMA" id="CEPNVFQ"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="394" mass="44920" checksum="EB876AFEFD45A241" modified="2013-06-26" version="1">MTSATDLFIVRAAPGKGLGIFATNTIKRGTRIICEAPLLRIARNDPHLAWKAYQRLSPQARQEYDQLHRFRRTELDLVREARTRLPGSDDPKVLADQVAVMERFSANNFMILGGNEHAVFKFSSRINHSCEPNVFQCFNPCLGMKTVHAMRDIQAGEEFETNYLGRECHYSSRTQRWEVFRSQWGFTCHCTACTDRTGVSDARHSLLGKVIYGLEEFIAGNPEMYNPFLPPSTLDALDQARDALSLCLEQNMYGPELVLAHRLISTFALELEDYQTALEAADNAQEVERNNMGTELDDLKAKGAGADVWKTHVLEMMRKAGFHSHQQRKPKKGTGKKNHKRSEQRVLKEVQSEFHQQKHGKKENHHQKQEKKVNHHQKQEKGDKQDADVAKIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD64</accession>
    <name>N1PD64_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_91483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD64"/>
    <dbReference type="STRING" id="675120.N1PD64"/>
    <dbReference type="eggNOG" id="ENOG502QVGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_1_1"/>
    <dbReference type="OMA" id="KCAVEYD"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF17">
        <property type="entry name" value="OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="59"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME40272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="489" mass="53428" checksum="426C9EADBC74AF0D" modified="2013-06-26" version="1">MSSIVDAFSNTITGIAHAQANSPFQQCIRHALGNHGKQFAFPQDILYQAQDVHPYNLDHPLIPAAVVYPKTSDEVSDVVICAHDAGIAVQPRSGGHGYCNYGLGGENGALSVDMKHFKDFNYNKDDHSITCGPGNRLGDLTDKLKPLDRVMAYGPSRDIGAGGHMTIGGIGVLGRQLGLGADQVISVDCVLGNGSQVTATESTNSDLYFAIRGAGFNFGIVTSFRMQTAPAPREVTQFAYNITAGKATDLADTFKQWQKFIAQPDLTRKFGCTLTLTEGLLIFGGTYFGPRSDFNQLNIEAILPNSHSRLNVHSSIVTETFNEIGALALDLFGKVPAHFYAKSLKTTPKTLLSDDAVDAMFEYIEKTDKGTHIWFVTWDLEGGKISDVPQKSSAYWNRDALYFLQSYVVSLLDDVGEKSKKFLDGLNKVVQEKTGADESAYPGYVDERLSDPHRSYWGGNVPRLQEIKAAVDPDNVFRNPQSIKPAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDS1</accession>
    <name>N1PDS1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_46877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDS1"/>
    <dbReference type="STRING" id="675120.N1PDS1"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_14_5_1"/>
    <dbReference type="OMA" id="HIHYVTD"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="4">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="35"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME40522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="110" mass="12265" checksum="2CA519A99B9CF54A" modified="2013-06-26" version="1">MGKEGVHNLTSKADFDKAREDTETLMVIDCFATWCGPCKVIAPQVVKFSDTYPNVRFYKVDVDEVPEVAQELSVRAMPTFFLFKGDNKEPIETVVGANPKALETAIQQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDY1</accession>
    <name>N1PDY1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 25 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_90923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDY1"/>
    <dbReference type="STRING" id="675120.N1PDY1"/>
    <dbReference type="eggNOG" id="ENOG502S152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032992_1_0_1"/>
    <dbReference type="OMA" id="PPIFAHH"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="359" mass="39902" checksum="26ED944DD49AA193" modified="2013-06-26" version="1">MLSHSLPVRVSLAVGAGLALLLLYLLSHTNHLPSSHFTPRKDTLDADALEHVFNSTLGFQKIFVINLPSRTDHRDTLSLAATLTGLEVEYVDGATEFDEGLLPPGGDPAKIGKGSIGAWRAHMNVARRIVEQNITSALVLEGDVDWDIRIKTQMHDFARASRQLLAPDGLDHDLLISDFRSDIAANSPYGDTELWDLLWIGHCGSRFAGGKNEKVPVGKVVIPNDQSVPEPQHLDFEYGEKDLLKDYPPHTRVVSRARMNVCTLAYGMSQAGARPMCDGLFGRPTHSCISVQPQLFQHHRPVGPKSKFSGISDHGDGFNEHAYTRNIRWSTRINFDKLVYGQTDYIDSYQDGQEEPERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE51</accession>
    <name>N1PE51_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_159235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE51"/>
    <dbReference type="STRING" id="675120.N1PE51"/>
    <dbReference type="HOGENOM" id="CLU_1424358_0_0_1"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050237">
        <property type="entry name" value="ATP-dep_AMP-bd_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767:SF1">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="228" mass="24816" checksum="14959512CA5A25CC" modified="2013-06-26" version="1" fragment="single">MSPHCTLAEDKGVDLKLPLVTLQQLFTELAKDFPDKTALICRHQSADFLHQVSQPSTNGSKCLRWTHSQLYAAGELLATRLHALGIRNGMRIAAFLRNGAQYAVGLYAAALLGAVFVAINPALATKSEEANYMLRTAEASALLAWDANMANDLDRGIEQDLAAKILVKAICNPPDTLPKGWHNLEDLLDPKSNYDQILLGDANKSHLDDLALIIFTSGTTSRPKGVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE65</accession>
    <name>N1PE65_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE65"/>
    <dbReference type="eggNOG" id="ENOG502SZ4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1796425_0_0_1"/>
    <dbReference type="OMA" id="RVHQFRH"/>
    <dbReference type="OrthoDB" id="4138121at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020301">
        <property type="entry name" value="Mrx7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10906">
        <property type="entry name" value="Mrx7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="144" mass="15872" checksum="099EB2B0347BBCFA" modified="2013-06-26" version="1">MAPWLRVLEAYMVQALLRTPAFHRAVEKVAKRVHQFRHGIPPEETGGTKIDGPQGDGGFGKHFLDEVKTQIGAAEQRETESGAVRTRGVRDGSVNARNAVPAEEDSDAAWQNMQKTAGQQPKAGFMDEYMDALREQVKNQKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEG5</accession>
    <name>N1PEG5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_27606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEG5"/>
    <dbReference type="HOGENOM" id="CLU_1704205_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109320" evidence="1">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="154" mass="16910" checksum="BB997A8176CC3970" modified="2013-06-26" version="1">MRCLLLLSALASFDVLGVIAGPVPDQDTALIPRADAGTEAAQPNTVSFDLDLTDSSKSKDDDDDGDTSCWWWWKCPKPKPTPKSSTEKFDWCFWGWCKPDDDDNKPVSWYGYQCPGKDDLSCDSCGGETGWDGKEYATKGWAAGCECSNDDDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEI0</accession>
    <name>N1PEI0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_65621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEI0"/>
    <dbReference type="STRING" id="675120.N1PEI0"/>
    <dbReference type="eggNOG" id="ENOG502R995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025638_0_0_1"/>
    <dbReference type="OMA" id="CDHYPHP"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06423">
        <property type="entry name" value="CESA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="8">
        <location>
            <begin position="184"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME41038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="469" mass="53908" checksum="18C9886C8E95AEB7" modified="2013-06-26" version="1">MAFSDWILDWTPFALVFTYYVVAVAIFCLVNQGTIKVFYFFLMATNFYIAATCVIESFLGLTPVRDARKAAMAVEATGKFPSDLNGKVKDLPIIDIVIVAYLPNERDIIRNQVLYACEELMYPKEKLRINLVYNTPKAIEPLETELSLLPEQYKNLRVIKVPGSKSKADNLNYFFGLQSDAEVIGIFDSDHCPHPHNPRWAAERFLADETVDIVQGRCVVYNTNESFYARMIAVEFDKIYAISHPGRSRMFGFGLFCGSNGYWKAPLLRAHKMHGDMLTEDIDSALRAYGLGKKAVHDMNVNSFEMAPNTFKSFWKQRLRWAQGWTQASYKHMPLLWTNPPNGKRTASERFGIISLLAIREISYYLVTLHTALLLSFIIVDWPTSVGAFVRLIFFRYPMAEWFFFATIVALLYTLYFTEKVRSEFTSFKDMLIFSVVYIPYLVLMATMGLYGHARQMIKYASWNPTSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEW4</accession>
    <name>N1PEW4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_137261</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEW4"/>
    <dbReference type="STRING" id="675120.N1PEW4"/>
    <dbReference type="eggNOG" id="KOG1145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="149"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="437"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME39826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="695" mass="76804" checksum="2C17E812CDBD6DCD" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEZ3</accession>
    <name>N1PEZ3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_91219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEZ3"/>
    <dbReference type="HOGENOM" id="CLU_903226_0_0_1"/>
    <dbReference type="OMA" id="HEYSGPP"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="31910" checksum="C4D254EE31A32BA3" modified="2013-06-26" version="1">MRWAESGKHNYSNSCSRARAARPSEIYKMPPRRVSSSSHQQPASPRKPFKAKTESYSFVNTYHSHSLSFLLINMKTTTLFALVAAATMGYASPGGESDAAAEYGTEETAPSYGGTGSTSSGSDDGSGSYSWGWKTDSSGSGSVSVSGWPVQRSGRFGGNKWGEDDGDDDGSDFYGSCPKCQVPPPGYAIPPPRIKWPTDLKKLPPGPIKDNFDAYGQACSSTNNVNDGNSGNSVGCCNKVSSGGSTSGGGGLFGGLLNGLLGGDTTCTLDILSSTCSSSSSIACCPTTDSGNGFSLINLQANCVPINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFB5</accession>
    <name>N1PFB5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFB5"/>
    <dbReference type="STRING" id="675120.N1PFB5"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009186_0_0_1"/>
    <dbReference type="OMA" id="GPHPTYE"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF2">
        <property type="entry name" value="F-BOX AND WD DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11400)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="130"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1156" mass="125799" checksum="C619D93764D40769" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH39</accession>
    <name>N1PH39_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH39"/>
    <dbReference type="eggNOG" id="ENOG502SR19">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062455_0_0_1"/>
    <dbReference type="OMA" id="EGGFGEW"/>
    <dbReference type="OrthoDB" id="5420711at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="390" mass="44458" checksum="923612CB93750D6F" modified="2013-06-26" version="1">MAGPSQYKQPAAVRNAADLEQGRIRNTSTGLMRPLYTSCAEHHHALERDALPHSPPQDFSQGRPRFLTLNTVPRLPSTPTAYKRASTMDSPFLRLPVEIRLQIYSLLVLPAEAEDLLPSFEKVASSTQDYFDYDKKQPGSSKPVTADLSNPTIHIRTVDPTRYKARFPREPPHRRSGYSVCADRFRARCMQTTYHSINIPRIEQNLGILRTNKQIHNEVAELLYGHYIFDFDTHIEAIIPFLSDLTPFARSCVKDVRIVQRALPYMKEFDKCEWSNALRYITSSHNDIHLRRLELGVVAGRPGQDGWDRIARYSAQDFEVLQQNDNMTWLQYLLEVEGLQEVDVQAVIEHCPPCTSSSAMASFVRFSASVETGFAEFLKSHLLKPTPSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHI1</accession>
    <name>N1PHI1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_72991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHI1"/>
    <dbReference type="STRING" id="675120.N1PHI1"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026447_0_0_1"/>
    <dbReference type="OMA" id="GPMNADH"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000232">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000280">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="103"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="231"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="409"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME42073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="506" mass="53761" checksum="2981DC24F7F6F31D" modified="2013-06-26" version="1">MADRDYDRGRDSRDRSPRESRRRSDYHDEQRRDDRSRSPRYRDRGDDREHRNRRDPSPRHSNGGRYESNDRETRPPPARSFEERQQAKDQMMKSVNESSQQDRRVYVGNLSYDVKWHHLKDHMRKDGTLDVLFADVLLLPNGMSKGCGICEYATRDQAQEAIATLSNTALMGRLVYVREDRETEPRFAGPPGAAGGRGGFQGGRGGFQGGGGFQGGYGGGGMGGGMGGGKTQIFVSNVPFGAGWQDLKDLFRQAGNVVRADVHTSPDGHPKGSGVVAFDTPEDAQNAIQSFHGYDWQGRILEVREDRYANSGPGFGGRGGFGGGRGGFGGRGGFGGGFQQGGYGGGGFGGRGGFGGGRGGYGGAGFGGGGYGGQGGGYGGGGGAAAAAGPPAAPNPFTDGAVSGGEPNPIIHVKNLPWSTSNEDLVELFQTIGTVEQAEIQYEGNGRSRGSGVVRFSSQPDAQTAIEKFQGYSYGGRPLGLDYAKYPDSGAMEGQEPTGSMQEQMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHU3</accession>
    <name>N1PHU3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHU3"/>
    <dbReference type="STRING" id="675120.N1PHU3"/>
    <dbReference type="eggNOG" id="ENOG502S41G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038171_1_0_1"/>
    <dbReference type="OMA" id="TCWILVD"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF4">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="169"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="389" mass="43386" checksum="ADB3DC591BD8DBCD" modified="2013-06-26" version="1">MENTGLPSKDSPDLHLVVATHEELIEQQHANSEEWRGALSLEQYIEREMVLYDQDLTRDGGLTPWVLIYQPDPNKPREVICGCESINKRALVAREGNVEDTICHGIASVFCPPNYRGKGYAGRLMADLGRKLKSWQADNGRACLFSVLYSDIGKDFYAARGWQPFPSAHVVIPPASKRPSPTARSLTTEDLSELCIADEELLRKRLSTVKTIGRTTVAVVPDNRTLRWHHAREDFVAKQLYGQPPHIRGAVVGDQPGSRVFAYWTRVWASPQEDGPNTLHILRIVAEDATLSDFAPASDETTGKLKSSNVAQDIAAVLSVAQYQAAKWDMKEVSVWNPTSATLAAAQLIDPSVAVQHREKDSITSLQWYGDSGSWQDIDWICNEKYGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI02</accession>
    <name>N1PI02_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_25852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PI02"/>
    <dbReference type="HOGENOM" id="CLU_1229906_0_0_1"/>
    <dbReference type="OMA" id="MANAIDM"/>
    <dbReference type="OrthoDB" id="3649689at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25514" checksum="B2464667B2A7FB59" modified="2013-06-26" version="1">MTLKKFALNYNHGSMAELLKFLKQRNGHDPLKSNIRKTRRQCRKRWIAKLRRLDLNATFRLLALPPELQNIVYDFALTHDRTKDSKACPAFLSASSRIHNDAVGISNANNVLELSNLFHRFVYHSLTTKWMELKQGGPGARSETIESGHNIAAYIPGLRSIQSIHLNLTFRQSSVRGINVPAGNWNDVTDFLTELLTSCQSLKHITVEIDDNPSAGDWGLQTQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIE0</accession>
    <name>N1PIE0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PRP1 splicing factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_154718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIE0"/>
    <dbReference type="STRING" id="675120.N1PIE0"/>
    <dbReference type="eggNOG" id="KOG0495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007010_0_0_1"/>
    <dbReference type="OMA" id="DGWAWYY"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001164">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative (AFU_orthologue AFUA_2G06070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME42147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="934" mass="105168" checksum="8EF1F9CF5CB2C5EF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIF9</accession>
    <name>N1PIF9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1 1</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_74581</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIF9"/>
    <dbReference type="STRING" id="675120.N1PIF9"/>
    <dbReference type="eggNOG" id="KOG2012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002556_0_0_1"/>
    <dbReference type="OMA" id="GANLHAF"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="13">
        <location>
            <begin position="930"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="806"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME41101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1064" mass="118452" checksum="1FAF9708EBA23768" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIN8</accession>
    <name>N1PIN8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_135568</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIN8"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OMA" id="NCATIPA"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="16"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME41415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="604" mass="67548" checksum="7F18A328A30F3147" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIR9</accession>
    <name>N1PIR9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_73191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIR9"/>
    <dbReference type="STRING" id="675120.N1PIR9"/>
    <dbReference type="eggNOG" id="KOG4299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001648_1_0_1"/>
    <dbReference type="OMA" id="CYYFVPP"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="586"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="955"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME42272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1007" mass="110498" checksum="EBAF57D6A8DE7460" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIX9</accession>
    <name>N1PIX9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_55307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIX9"/>
    <dbReference type="eggNOG" id="ENOG502TJP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1107696_0_0_1"/>
    <dbReference type="OMA" id="YRICIVT"/>
    <dbReference type="OrthoDB" id="3637222at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="244" mass="26427" checksum="8157D55B616122E5" modified="2013-06-26" version="1">MSIIDRSAPINLQYRICIVTSASSPLGVVISKTLLKANAFVLGVDTKPIDPSLNAGLGTHFQFEQLDVEEEGQTPKRLIEAAKEKFGLENIDALVNIFGKQNDGRGLGKLSTALGQVMAQQKKGTIVNVRDNVENEDGKQQERLLDFTKNISQRLENEGVRCNAVVLQAPPNAGQYQSGKAYEEAQTHMKTLMNIEKLQATPASTKAAPKMYDVGNVILFLAGDMSSGIRSSAVLTDGSYTSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ62</accession>
    <name>N1PJ62_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ62"/>
    <dbReference type="HOGENOM" id="CLU_2346662_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="97" mass="10614" checksum="5E38C0301499F6F0" modified="2013-06-26" version="1">MMSHGGWGATCIFQALEECHCHIAMGVQHASPNWYAASKTHDSTFFDEDMLSFLDNIAQKGTTSVWLPDLSLPSTKGALLTRNTISKIPLVDVPAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJU3</accession>
    <name>N1PJU3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DEAD/DEAH box helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_79760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PJU3"/>
    <dbReference type="eggNOG" id="KOG4150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000809_1_0_1"/>
    <dbReference type="OMA" id="AAEHVIM"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="376"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="673"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="896"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME43777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1465" mass="165897" checksum="4808FAFFD3D43927" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK46</accession>
    <name>N1PK46_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_177361</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK46"/>
    <dbReference type="STRING" id="675120.N1PK46"/>
    <dbReference type="eggNOG" id="KOG0663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="WVARATN"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="101"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="396"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME41940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="461" mass="51774" checksum="EEE8261BE4609CCA" modified="2013-06-26" version="1">MPSRWADTEEDAAEDARRKAEKEEKKRLKAEKQRKAEETQRAAPAQANGHSGADDNERPSKRRRISHEDQEDAESAAPAAERKLLRFNAPSWQPCRSVERFDRLNHIEEGSYGYVSRAREEATGEIVAIKKLKLNPATDGGFSVTALREIQCLSAVKHRHIVELREVVAGQGNSRGDVYLVMEFLEHDLKTLEEEMDEPFLPSEVKTLLLQLGSAVEFLHDHWILHRDLKTSNILMNNRGEIKLADFGMARFCGNPPPQNLTQLVVTLWYRSPELLLGATTYDASIDMWSIGCIFGELLTKHPLLQGKNEVDQLSKTFELCGIPTEETWPGFKRLPNARSMRLPSNSKSAQGSIIRSKFPTLTNGGASLMNSLLSLDPSKRPSAKEMLEHAYFREDPRPKPTAMFPTFPSKAGQENRRRHASPNAPIRGAAPGLQGDVDFNSIFKGREEEEKGGGFQLRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLG5</accession>
    <name>N1PLG5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_34439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLG5"/>
    <dbReference type="HOGENOM" id="CLU_2049651_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="120" mass="13160" checksum="66D2AAE527A7CD4C" modified="2013-06-26" version="1">MLFAITDDLLAFYHLSIVEKLIGKAASHSITNFAGLLTSCQGLGNKTGQNDPELIDDRVSQGKSFASQNDELGPLATTSPTWRLSFQTSAESSHRSFNARRRMRTFSTNTVETKSTKSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLH3</accession>
    <name>N1PLH3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_72001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLH3"/>
    <dbReference type="STRING" id="675120.N1PLH3"/>
    <dbReference type="eggNOG" id="KOG3141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044142_0_1_1"/>
    <dbReference type="OMA" id="GKNIPCT"/>
    <dbReference type="OrthoDB" id="274683at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000004">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.810:FF:000001">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_uL3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME44352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="311" mass="33500" checksum="94EAF776DC124289" modified="2013-06-26" version="1" fragment="single">MPPVLPAPLFAVPPRCLCPSVPRQFVRTIRSIQPKQRGGTHPERFNLRKDMPTLGSSQDAAFMRKEVNFPLRTGTLAIKKGMTGMYDPTTAKREACTVLQLDRCQVTGHKRRDVHGYWAVQVGAGTKEARNVTRPERGHFAANNVPIKRHLAEFRVKNEEGLPEVGSIITADLFQEGQYVDARGTTRGMGFAGGMKRWGFSGQPASHGNSLTHRAMGSAGASQGSGSRVLPGKKMAGRMGGERHTVQNLKVMKVDTENGIVVVSGAVPGPKYSIVQLQDAIKKPWPSVDISSGLSNVGGEVSKEAPAAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLY5</accession>
    <name>N1PLY5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLY5"/>
    <dbReference type="HOGENOM" id="CLU_2427013_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="91" mass="10453" checksum="68E09CB04572ACB0" modified="2013-06-26" version="1">MPLIHDDPQYILTVRRSHRRPFVTGMACACGCACDYGVRCRQCGGRVVNRNYSGEAKESSEESRIDCSESTRRDQTPEDERQLLDYVNDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLZ6</accession>
    <name>N1PLZ6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_175741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PLZ6"/>
    <dbReference type="eggNOG" id="KOG1823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000327_0_0_1"/>
    <dbReference type="OMA" id="EGLMAMF"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="869"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1620"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="4">
        <location>
            <begin position="2192"/>
            <end position="2512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2348"/>
            <end position="2370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2473"/>
            <end position="2524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2473"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2497"/>
            <end position="2512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2513"/>
            <end position="2524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME42565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="2524" mass="280679" checksum="5D5352D7314FDC7A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM68</accession>
    <name>N1PM68_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Versicolorin reductase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dothistromin biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_72139</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM68"/>
    <dbReference type="STRING" id="675120.N1PM68"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_4_3_1"/>
    <dbReference type="OMA" id="AAYQMSQ"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF26">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_4G05870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME44582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="298" mass="32742" checksum="24A49B80FCC5848E" modified="2013-06-26" version="1">MSSDKKEFESGFQPDVQHQKVPGLQSDMTPAPSTEYVPTPDGGYKLYQAAGKLKDRKALITGGDSGIGRATAVLFAMEGADSFIAYLPEEEKDAQETKKLVEKYGRKCYLHSTDLKDKNNCKKVQEEALEKLGAINILFNNHAYQMMTNDIHDLSEEQWEHTFNTNIHPFFYLSKYVLPHMKPGDTIINNASINAYIGRPDLLDYTSTKGAIVAFTRGLSNQFVHKGIRVNAVAPGPVWTPLIPATMNEEAIKQFTSPMGRPGQPSEIATCVVFLASTDSSQLSGQTIHANGGVIVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMF4</accession>
    <name>N1PMF4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_54936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMF4"/>
    <dbReference type="STRING" id="675120.N1PMF4"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OMA" id="FELWTVF"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF576">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CSK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="93"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME42626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="393" mass="43735" checksum="F08899CB6F1AAD1A" modified="2013-06-26" version="1">MVDEWHKAVTFTDRLEHITEMQHQTEAKKYAKALEETARKTASSLQEYHELCSKQAKLLTARAKFHLSPGEDQHPNEHLFPNLPAHGATIGKYTNAEHFNDGLFSEVFRAADPEVTLSNGKSRIVALKITTPALEQPPHNSRREARVLEAAKNEHVIKLLETFHPSGDRFVLVFPYMPFDLNQLLHQQRLTPQSRRAVLKDLFAGLAHLHSLDIVHRDIKPSNILLASSKGPAYIADLGIAWSPTGASSEPADQKYLEVGTTCYRPPELLFGHASYGTKLDMWAAGCVAAQVTCLNDQTLFDAGDLGSELALIKSIFSTLGTPDLETWPEASTMPDWGKMNFVKYPCKDWNQILPTADAQARALVADLVCYESASRINAQVALKHLYIGEPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMQ2</accession>
    <name>N1PMQ2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_71875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMQ2"/>
    <dbReference type="STRING" id="675120.N1PMQ2"/>
    <dbReference type="eggNOG" id="KOG1780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_10_0_1"/>
    <dbReference type="OMA" id="MSKAQPP"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000019">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME44198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="85" mass="9584" checksum="55FE4E985249B5D9" modified="2013-06-26" version="1">MPQAQPELKKYLDKRVEVQLNGSRKVMGTLRGYDVFLNIVLDEATESKPNGEKARLGMCVIRGNSVVMMEALDRIDSDNRHHGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN65</accession>
    <name>N1PN65_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_72005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN65"/>
    <dbReference type="eggNOG" id="ENOG502RI6N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_933918_0_0_1"/>
    <dbReference type="OMA" id="DCESCLI"/>
    <dbReference type="OrthoDB" id="4729724at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="102"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="298" mass="32391" checksum="711CB974440E2E72" modified="2013-06-26" version="1">MASQHEVIDLTGSDDDLTAILPRPPTARQDTRKTIEISDDDDEVEIASDSDDGGNEHADEDLVGPLLAALAGPQNDRLPFELPPARAPMPASPRHNTPVRGAEVVMHLFADGSFVNGRFGGAGVAWRDKIWHGRAIALGRVKDSFAAEMHAVLEGIKAAHAIVDRRSEFTKVVVQTDCESCLIELARARAAGGGHYGLLDEIIHQEALLKSRGLDVVVWWVKGHSDSVGNDIADSLARYGAERARTSPTCWGVVIENPPSMKLELANRLRHSDRKPHQAITAPGTRRAKKEAKRRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPJ6</accession>
    <name>N1PPJ6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_71961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPJ6"/>
    <dbReference type="eggNOG" id="ENOG502QW6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011003_1_0_1"/>
    <dbReference type="OMA" id="QKGVGFH"/>
    <dbReference type="OrthoDB" id="4060227at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME44300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="641" mass="71776" checksum="70563548046EDC24" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ07</accession>
    <name>N1PQ07_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_128531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ07"/>
    <dbReference type="STRING" id="675120.N1PQ07"/>
    <dbReference type="eggNOG" id="ENOG502SYNC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1045816_0_0_1"/>
    <dbReference type="OMA" id="MGAWGYC"/>
    <dbReference type="OrthoDB" id="3648505at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="228"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME45516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="277" mass="30771" checksum="A6B2E83227E029CD" modified="2013-06-26" version="1">MGAWALKLFMCDYDLDLIGHLGVEVGLPALEQQQTGKTATDFRNPASARMLDHQSGRGARYSLYAKLCSHPEVVRKYLDDGALSRVTADLRRKINAAHEWWLKDCYGPGYHLCILGACTMTLGAVLSNQDKAAIRAVYKNCELMRDAVTQLDAALDLHTGYVNGVPWNFGVSSIGEIELASKEDLAFPAKGMINVRGPDHGRNLSYDPYTDEMMALRHPDGMWKDHACGECGSSQSGHGQALLKCSKCKKRCYCSKDCQKEHWKNHRGFCRAPRSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQA0</accession>
    <name>N1PQA0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQA0"/>
    <dbReference type="STRING" id="675120.N1PQA0"/>
    <dbReference type="eggNOG" id="ENOG502RP42">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076645_1_0_1"/>
    <dbReference type="OMA" id="WSKLNKQ"/>
    <dbReference type="OrthoDB" id="10263401at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13376">
        <property type="entry name" value="OmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="212" mass="23779" checksum="639D2D07AE51353E" modified="2013-06-26" version="1">MPGVWLTVAKKDTQSPTSMTYADALDEALCYGWIDSRMRKLDEYTNSCRFTPRAPKGLWSKRNVGYIERLQREGRMQPAGLAQVEAAKADGRWGAAYSAQAEPPAEFFEALKQNVKAQTMWDELNKGNKWHIYFTLLNLKTEAGKEKRIRGFVEMLARGETPIPQKNAAAKTATTTKRAASEMASLDQVVPEQVLSRKTRSGRNAPSYSDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQP4</accession>
    <name>N1PQP4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_43976</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQP4"/>
    <dbReference type="STRING" id="675120.N1PQP4"/>
    <dbReference type="eggNOG" id="ENOG502SGAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_6_0_1"/>
    <dbReference type="OMA" id="EPCIYDR"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="423" mass="47188" checksum="54D20AED90610A2C" modified="2013-06-26" version="1">MSSGNGPNGVRKPTVRAPKVGHKKSRKGCQTCKIRRVKCDEIAPECGNCQRLGLDCIYVAPEPTRARPKSQSAEAPSRLIKASPGELSDDSPPGSNGDASTQPVPATPTQDLVAEESEQRRYIELRLLHYWMCQVSRPFGMTSPPEWKELWYGEVPQVALDHKNVLYAMFTMTATHMLGRGAKDPTIYTARENYWILALREQTNAVSDLDNCNTDAVAFSALLITLNALAMLQERSLEPYSPPMDWLEVGRGAFTVLPSPENVADGTGLKILMETTAPIWQAAYSLEADIKKEFGGVLNRDIPSADVWDEETTESYETTLSYIAAFRRVILSGEAADINLRWICMFPFMVPRKFIDFVGEMRPRALVILAYFFAVIAHTDALQYLGNTADNATAKREIYAIRRILPEEWLSYMAWPLQEVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQQ4</accession>
    <name>N1PQQ4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_72265</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQQ4"/>
    <dbReference type="STRING" id="675120.N1PQQ4"/>
    <dbReference type="eggNOG" id="KOG2042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003224_0_1_1"/>
    <dbReference type="OMA" id="WLTEIAM"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="993"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="543"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME44754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1081" mass="122562" checksum="B761D7A268750E89" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQS9</accession>
    <name>N1PQS9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_23731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQS9"/>
    <dbReference type="HOGENOM" id="CLU_1917025_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14207" checksum="544959C5DC1AE2E7" modified="2013-06-26" version="1">MHLPIFSTSTIPTSTFSKFLQPGNVDCISSYTPAPAADVVACNDQIKAKGDQECVVSGLFDYDVFCTYGRATVGGVLNASANGNRTSIPCIEIAQAVGHIMDDCTSDKTVKGVYRLETNPYIDVWINYKSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR44</accession>
    <name>N1PR44_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_78366</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR44"/>
    <dbReference type="STRING" id="675120.N1PR44"/>
    <dbReference type="eggNOG" id="KOG0786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_1"/>
    <dbReference type="OMA" id="FRYSLDM"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF4">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="25"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME45916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="395" mass="42218" checksum="FFC55CCB79C18FDB" modified="2013-06-26" version="1">MATTASNTASANGPTANVAPAKGGKILVLPGDHIGPEVVTEALKVLDIVEQATGAKFERDFDLCGGCALDKHKDSVTEEVLQKCEKADAVFFGSAGGPEWGTVQPNPESGLLRIRKRMQIFANLRPCKFASKTMVDWSPIKREIIKDVDFMLIRENCGGAYYGDKVETEDYGRDPWEYSRPEIERVARVAGALALQHDPPLPVFSADKANVLANSRVWRRVVTDVFAKEFPQVTLQHQLADSLAMLFITKPTAFNGVIVTDNTFGDILSDESGGLTGSLGLLPSASLAGAPGTDLGRNSVGGVIGLYEPVHGSAPDISGKGLANPVAQVLSLAMMLRYSFNMHHEADAIEEAIAKVLDSKADGGLEVRTGDLGGKATTKDMSEAIQAEVKRLLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRQ1</accession>
    <name>N1PRQ1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_110863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRQ1"/>
    <dbReference type="STRING" id="675120.N1PRQ1"/>
    <dbReference type="HOGENOM" id="CLU_057752_6_3_1"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="153" mass="16525" checksum="52E6C686482F7727" modified="2013-06-26" version="1" fragment="single">DNKEYSDLFLECGGKEGKVHKAIVCMQSPYLAVISEDNTRTVRNAVNISLTSGDAGIIDALVQFMYTFNYAASAGTPVNSNRGALTFNVAVYTAAEKFGIQPLARLATSRFCSLAKQRWDTADFCCSIRALYSLAPNSARAMNITVVEVAAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRY6</accession>
    <name>N1PRY6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_87604</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRY6"/>
    <dbReference type="SMR" id="N1PRY6"/>
    <dbReference type="STRING" id="675120.N1PRY6"/>
    <dbReference type="eggNOG" id="KOG2553">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021971_1_0_1"/>
    <dbReference type="OMA" id="NKAFDCR"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="487"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="329"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME45184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="679" mass="77385" checksum="211D5CB27E007B23" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS78</accession>
    <name>N1PS78_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_22328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS78"/>
    <dbReference type="STRING" id="675120.N1PS78"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027389_3_0_1"/>
    <dbReference type="OMA" id="HQNAAMI"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF2">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="309" mass="33030" checksum="978D0298D46D7240" modified="2013-06-26" version="1">MLTNGQASKPAGVQRLREMLSDPSKTVVAPGVYDGITARLALAAGFECLYMTGAGTSMSRLGMADLGLATFNDMHQNAAMIASIDPSVPVIADADTGYGGPINIARTVQSYARAGVAGLHIEDQVQEKRCGHLSGKLLVSRQVYLNRLRAACRARNESRDDILIIARTDARAGTDTEGNGGFDEAIERLKGAAEIGVDALFFEAIQSLDEANEVIKRLPKIPVLLNMVQGGRTPQVSNDEANKMGFRIVIWPCLGMEAIVPAFRTSLESLKTTGQPPSDQKMGPPALFETCGLKELMAFDESVGGKAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSY8</accession>
    <name>N1PSY8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_71288</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSY8"/>
    <dbReference type="STRING" id="675120.N1PSY8"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_12_1_1"/>
    <dbReference type="OMA" id="RHDMQKC"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031852">
        <property type="entry name" value="Vik1/Cik1_MT-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16796">
        <property type="entry name" value="Microtub_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="309"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="226"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="402"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME45529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="705" mass="78796" checksum="3D2CFDBDA14850DA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT55</accession>
    <name>N1PT55_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_70542</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PT55"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_82_4_1"/>
    <dbReference type="OMA" id="AMCNLIM"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058846">
        <property type="entry name" value="PAS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
        <property type="entry name" value="TWO-COMPONENT SYSTEM RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26131">
        <property type="entry name" value="PAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="927"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="1000"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="1076"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1407"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1352"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME46562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1550" mass="169562" checksum="47EA87ABCDA44A8E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT72</accession>
    <name>N1PT72_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_71337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT72"/>
    <dbReference type="STRING" id="675120.N1PT72"/>
    <dbReference type="eggNOG" id="ENOG502S74C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166990_0_1_1"/>
    <dbReference type="OMA" id="EKPAIFW"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8451" checksum="105C860FA2FE04EE" modified="2013-06-26" version="1">MAPVTFWQAPRQYLQWAVRAKPAIFWSIVLGSFGPVAMVVVPPLRARFGDGPRQQIPLSYPIPRGQRKIPSGYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTH9</accession>
    <name>N1PTH9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTH9"/>
    <dbReference type="STRING" id="675120.N1PTH9"/>
    <dbReference type="eggNOG" id="ENOG502T6XG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1175881_0_0_1"/>
    <dbReference type="OMA" id="PPHEIRI"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28514" checksum="BFF6F3774B69E0F9" modified="2013-06-26" version="1">MFSSDDKVAEATRLAEQHEFITSGLGFLIHPVIEHHINDYEAPVRIADISQGLQFPPNNDPRLPRCKLETVRMSIKDVVHPDGVQEYAGMFHVVAVRLAHLIIGNRDWNTAVDNLISLLRPGGWIQWTDWDPRTARIAGVKPGAEDKALRNLLEKYSDVLKEKQVGTTYRISSSFTEAGLVEEDSDMYPLPPDSGLTSNIAHGALRQLETVGSVGSGEIQQLIRGVDKEIEAGNSLIWYDLWCHIARKPKQSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTS7</accession>
    <name>N1PTS7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_71453</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTS7"/>
    <dbReference type="STRING" id="675120.N1PTS7"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_7_4_1"/>
    <dbReference type="OMA" id="GYDSAMN"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="17"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME45770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="392" mass="44619" checksum="066C5B638BCCD991" modified="2013-06-26" version="1">MSSSPAIKLRRKKNVKKGIQFCLMVCGASGTGRTTFVNTLCGRQVLTPLDTDDPTTAHLEEGVKIKPVTVELELDEEGTRVSLTIVDTPGFGDSIDNEASFSEISSYLERQYDDILAEESRIKRNPRFRDNRVHVLLYFVQPTGHGLRELDIELMRRLSPRVNVIPVIGKADSLTPLELAESKKLIMEDIEHYRIPVYNFPYDIEEDDEDTVEENAELRGLMPFAIVGSDDILELDGKRVRARQYPWGVVEVENPRHSDFLAIRSALLHSHLADLKEITHDFLYENYRTEKLSKSVAGVNEGTGSINPESDSLDPQSLASQSVRLKEEQLRREEEKLREIEVKVQREINEKRQELLARESQLKELESRMVREQTPSQPMLDHDDESVGGATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTV9</accession>
    <name>N1PTV9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_70744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTV9"/>
    <dbReference type="STRING" id="675120.N1PTV9"/>
    <dbReference type="eggNOG" id="KOG2429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_2_0_1"/>
    <dbReference type="OMA" id="CTPLTRD"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109341" description="alpha-1,2-Mannosidase" evidence="8">
        <location>
            <begin position="38"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME46891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1075" mass="118397" checksum="224AC94E0EA7310B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUD0</accession>
    <name>N1PUD0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_77444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME46992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUD0"/>
    <dbReference type="HOGENOM" id="CLU_1019509_0_0_1"/>
    <dbReference type="OrthoDB" id="10621280at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="273" mass="29771" checksum="E50970935CFBF5AD" modified="2013-06-26" version="1">MHSSPTSAHTCPAGPSHHDSESETMSHIVKSTQPGTINGVLVREYAIVEFSYFMSPGMRSHNQAWTTQKAVPFDFPIGNLTSLCDAACKMTRSPNHRFMLYLKGKGGGMHMSAAIKFHDERDLYANLTAGIKPRITTIRYLFSGLNLEDAKQSREPLFIPIAVDVFLPSESESDAHPLPKFTPSPHFTTPLPPRAPSPSSNLHSFSPSPIPLNGPLSISLCIHLINHLHTLSLDHIPLPARISTTPSGSSNGTSMIRGHEFFATRRSAGDVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUS2</accession>
    <name>N1PUS2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_22259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUS2"/>
    <dbReference type="HOGENOM" id="CLU_1194861_0_0_1"/>
    <dbReference type="OMA" id="HISAMQD"/>
    <dbReference type="OrthoDB" id="10537897at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="232" mass="25222" checksum="AE6E6CA9C4A59D0F" modified="2013-06-26" version="1">MTSGAHTARAAADQLQQTHELAVPDGSSPSRSAMVDTVEQNLHEIAAESFIAANLADVDTRNADQNAVYHGMKVDITAEKCVRGLTSQHFSAMQDKAMTGNFAVLSKVEYEPDSKRMRDSDEENKENEEEVENNSEEEEEEPRDDSEVGEDGAAAYPATATTGQPKGAIGRYRTDSNDERFDVKYVEAHPQENFTHKGKGSWKRGLPGPGDNIKSGVRGPGAAGWRKANIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUU5</accession>
    <name>N1PUU5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_70241</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUU5"/>
    <dbReference type="STRING" id="675120.N1PUU5"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_0_1_1"/>
    <dbReference type="OMA" id="MMLVGDI"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000063">
        <property type="entry name" value="Phosphoribosylpyrophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000014">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="14">
        <location>
            <begin position="6"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="115"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME46184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="465" mass="49971" checksum="631E72994EFF47F4" modified="2013-06-26" version="1">MVRNILLFAGSSHPQLTDSICAHLGIPSAKITLGKFMVGETRVEVGESVRGKDVFIVQTACSTKNGSSGGMSLNDGLMELLITISACKTASARRVTAVLPLFPYSRQSDLPYNKVGAPLARMPTKRGDDGKYTFDSRPGTPGPGGQRKDEHLERNMKHLTYGVGELHIPPGRKDTLESVRSDASYDSSPGSANGHKHASPTSAPISAANGTTTSFPTGSAPPEFKPQRGYKQWVAQAGTLVADLLTCAGADHVITMDLHDPQYQGFFDIPVDNLYGRNLLKRYITHDILPHEGGPDQCVIVSPDAGGAKRATSIADALGMEFALIHKERRNPNHSGPNPANALLLVGDVRARTCILVDDLADTSNTITRAAKLLKREGAERVYALVTHGVLSGDAVDRIFWSGLDKVVVTNSVPQQHHLDKMDELAAQHGKPAGKLEVLEIGGVFAEAIRRVHHGESISVLFQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUY7</accession>
    <name>N1PUY7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 79 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_70277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUY7"/>
    <dbReference type="eggNOG" id="ENOG502S1KG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022148_0_0_1"/>
    <dbReference type="OMA" id="RINYQQI"/>
    <dbReference type="OrthoDB" id="2831684at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109362" evidence="1">
        <location>
            <begin position="24"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="415"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="527" mass="57226" checksum="78D8C4206A1A3E3E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVI3</accession>
    <name>N1PVI3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_70380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVI3"/>
    <dbReference type="STRING" id="675120.N1PVI3"/>
    <dbReference type="eggNOG" id="ENOG502SNKW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013866_5_1_1"/>
    <dbReference type="OMA" id="SAGCENC"/>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME46360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="627" mass="69999" checksum="2A4986B1C23E140B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVW1</accession>
    <name>N1PVW1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVW1"/>
    <dbReference type="STRING" id="675120.N1PVW1"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_1_2_1"/>
    <dbReference type="OMA" id="DIHARPC"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="188"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="403" mass="45435" checksum="7263A8A68236FAF5" modified="2013-06-26" version="1">MTDNSPSGAIGTETDRPKMNGTTDENSRPASFVSAVSSQHQTADTPASSATQTTAGAEREEEEWMPPANGPLKTPIPKPSRHSMIPPQSRLSAEQETKYTAVREQVSQWTTIPTSTAKGAAQAPIEEYERMFLTRECLLRYLRATKWRPADAVRRLQETLSWRREYGADTFTHDYISPENETGKQVQLGYDNEGRPCLYLNPGKQNTKMSDRQIHHLCYMLDRTIDMMPAGVENSALIINFQGAASGTTPSVGQARAVLNILQGHNPERLGKALISKTPWYVNTFFKLISPFIDPVTREKMKFNEDLRKYIPVEQLWKDDGGELDFEYDHAIYWPAFDEECKRRRDAYRKRWEEAGQRIGEYEEYLRGGNHPSLQQGTGQASETIVQSHAVDSAAEGVGKLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVX8</accession>
    <name>N1PVX8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_70501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVX8"/>
    <dbReference type="STRING" id="675120.N1PVX8"/>
    <dbReference type="eggNOG" id="KOG4134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036411_0_0_1"/>
    <dbReference type="OMA" id="TYYPPFN"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000004">
        <property type="entry name" value="RNA polymerase I subunit Rpa43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="9">
        <location>
            <begin position="131"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME46515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="213" mass="23488" checksum="DDBA4EAFC64C54E2" modified="2013-06-26" version="1">MGNMAKKIKRSKSATANTNSPVVGQKSPLIQQTTSLYLTLSPTAYDDTKDGAEPRVHSMPVKGLCAEHIAPHLLSYYSPLNGILLNFSNPRISETSEDIFRTETAPVLSHSIDEYAVSYVWLTCDFLIFRPSKGVKLDGVVSLQSESVLGLLCYNYFNAAIEREKLPEDWNWNGEKWLDGAGKEVSSAITFIVEDFEASGQDGISIMGTMREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW32</accession>
    <name>N1PW32_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_69602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW32"/>
    <dbReference type="STRING" id="675120.N1PW32"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021597_0_1_1"/>
    <dbReference type="OMA" id="GDRMFCH"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="390"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME47706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="503" mass="53292" checksum="A7829D4E886B94C0" modified="2013-06-26" version="1">MSTQTPQQAPQQRELVFCHQCENEWYRDEHGIICPDCQGDFTEIIEEDHDPREDDAMPELDPQFPGHGHEWYAPNAPDPDEADIDDLHWEENAPGGPPGGRLTGTLTRNIRLGGQGGQQGGQSGGGFMGMLGPILQGALGGVVNPTRQQGQGQGQERGAEGVEGQHPPGSSPGEQQRGNGGTYTRHAHGPGYSFTITTSTGGNLFPRDANNPQPFQQQPDNIERLMAQMFANIGAGPRIQGPGAGGPFMGMGMAGGPGPGEGGMAGGPTMFGDIFQLLGMAHGGAHGDAVYSQEALDRVITQLMEQHQSGNAPGPASSEAIENLPEKQISAKDLDENGEANCSICMDSAEIGSTVTELPCHHWFHYDCIKSWLIEHDTCPHCRQGIMPKDENARADRPRHSSQAPMHDMHSPDYHRAPSMPGGHPFPRQNSSGAEGSGRGSASQDDPFRVSVSPERSRNGGAAGGLFGRMRQAFSPGGSSSNPDDVDSQGTGGYGGSLDSGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWN0</accession>
    <name>N1PWN0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_69673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWN0"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024886_0_0_1"/>
    <dbReference type="OMA" id="SEKWIIP"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110250" description="FAD/NAD(P)-binding domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME47817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58883" checksum="9C661E8288B38508" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWU9</accession>
    <name>N1PWU9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_149362</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWU9"/>
    <dbReference type="STRING" id="675120.N1PWU9"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="OMA" id="CRGRNGD"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="25"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME46885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="364" mass="39674" checksum="2F67EE1ECB487EC6" modified="2013-06-26" version="1" fragment="single">MTSEKILQPTDFVGWMGLDKTAAQGTMVWQQFPDPKPFEETDIDIEISHCGICGSDIHTLRSGWGPTPYPVCVGHEIVGKAVRVGSEAEKGIKVGDRVGVGAQNSSCLKGDCEECSEGLEQHCVRSVNTFADKYPNGGTSYGGYANYHRAPSHFVFKIPDAIPSAEAAPMLCGGITVYSPLVENGCGPGKRVGIIGVGGLGHFGLLFARALGADRVVGISRKNNKREDVLKMGADAYIATEDDKNWHKTNARSLDLIICTVSSPKMPLSRYLQLLRTKGTFIQVGAPEDKLPDMNAFHFIGKGVKFGGSMIGSPRQIEEMLQLAAEKKIKPWISHYDLKDANKAVVDFEEGKARYRITLENRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWX7</accession>
    <name>N1PWX7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_21648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWX7"/>
    <dbReference type="HOGENOM" id="CLU_534205_0_0_1"/>
    <dbReference type="OrthoDB" id="10661006at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="510" mass="55066" checksum="00EE96EF8E7755D6" modified="2013-06-26" version="1">MGPWTGGYGTQIEVTTASSGGSTGSTTHVGKALATLVVPQPEDYGRHPATADWEFDITDELRQQIADAINEACQESGYYLDQAGRRRDIGSLFCKIGDLTGVGQMFFDGRTLITPKKIQDAIVDNVIEAPAALAPAYAQRGKFRTQWKWAFLLTTAILHAAERINYVPSHFVVGPGAINDVMEDDQTPWSTRPDGTKVTTTSTTSEAPSCPTDAYIDPNDDQGQDGIPPEASIQGELSSAYASMAKAVGLIPGAGPQTCTKTVTAPVPSCKLTKQTTNINQPSRVCVCPFGSITQTVPTSTSTITTCDGNGSGTHIDVCPWTAAPPTSLNIPLPTGMKYPGGTMPPVQTQAPYNNPTTDPGWDYGVLSQALRDFCHNRATDRLHLGDRPNDTVHFLETHNNLGKKSIPKNQDFAIWLGWEPRACADEKKKVAGYTFLDEDEAECVSTFMAIVNNTPNKPKPKDQLGGPDFKVCGGMYHKCVWYEIAGRGKFPKMYKEGITLHSDLKDPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXA1</accession>
    <name>N1PXA1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G protein alpha 3 like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">gpa3</name>
        <name evidence="13" type="ORF">DOTSEDRAFT_69926</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXA1"/>
    <dbReference type="STRING" id="675120.N1PXA1"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="OMA" id="FMAIQAM"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010856">
        <property type="term" value="F:adenylate cyclase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010619">
        <property type="term" value="P:adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="179"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="204"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="273"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME48146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="356" mass="40893" checksum="F4721BF2ACEC3A8D" modified="2013-06-26" version="1">MGACMSSGSNEDGDQKKRSQMIDRTLEEDSKKLRRECKILLLGSGESGKSTIVKQMKIIHQNGYTTDELALYRHTIYKNLIDCAKALIGAMRQFEIDVEDSANREYCDFIMEYVVDPDPQQPLDTRVGEAIASIWQDKCIPKVFDHQNEFYLMDSAPYFFEEVTRLAASNYIPTEADVLRARTKTTGIYETRFQMGQLSIHMFDVGGQRSERKKWIHCFENVTSIIFCVALSEYDQVLLEESSQNRMMESLVLFDSVVNSRWFMRTSIILFLNKVDLFRAKLAKSPLGNYFPDYSGGNDVNRAAKYLLWRFNQVNRAHLNLYPHLTQATDTSNIRLVFAAVKETILQNALKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXL0</accession>
    <name>N1PXL0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_85703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXL0"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_3_1"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF53">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME47135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28725" checksum="234B651D82DA5FD9" modified="2013-06-26" version="1">MAEKLATEQVHIGFGFSPETSLWLTDGEKFMAAERLRIKPRSHSNQQVKPHHIKRAILDINDRICSAGFFCTNITVQGLSVFKPTILKDLGWTTTRAQLYSVPVYVSVSAIAMFIAFVSDKTRQRGLYLAAFTIPGITGFALLRWNLDANVQHGTVYLCALIAFPGRPGCFGWIVTLGAIGGVVATWWYLATDGPDFPTGHPINLIAHILVLCLSVGGIAYCIWENKLRALGGRDDRLHGLNEEEIAGSGYRHSHFRCIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXS0</accession>
    <name>N1PXS0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_69108</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXS0"/>
    <dbReference type="STRING" id="675120.N1PXS0"/>
    <dbReference type="eggNOG" id="KOG2917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043216_1_0_1"/>
    <dbReference type="OMA" id="AVNPQMD"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990932">
        <property type="term" value="F:5.8S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="112"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="257"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME47014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="334" mass="36446" checksum="F4B2431EE4BA82F5" modified="2013-06-26" version="1">MPSAQINQPSNQIKLTNVSLVRMKKGKKRYEIACYKNTVTSFRAGNEKDLDNVLQIPNVFLNVSKGQVAPNEDLKKSFPGMTRDEIVLEILKKGEIQVGEKERSQELERVHKEVIEIVAGRLVDPKSKRVYTAGMIEKALDQLSSQGGHAGRGAGKGSKEIAEGSDRSKSREQSSARTNESGSSTPARANGEGNTGLEGNLEKLAVKPKWTGVTTNKNAKSQALDAIKALIAHQPIPVARARMRLRITSPTSILKQSVKSAPKAEGEEATTGTVKDNILSFIEQVENQDVVGEEWECLGFVEPGSFKTLSEFISTHTKGKVRAEVLDTTVTHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXT1</accession>
    <name>N1PXT1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_97728</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXT1"/>
    <dbReference type="STRING" id="675120.N1PXT1"/>
    <dbReference type="eggNOG" id="KOG2121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006220_0_0_1"/>
    <dbReference type="OMA" id="MSHCKHT"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="12">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="858"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME48227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="920" mass="101186" checksum="30A33114B874C31C" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXW3</accession>
    <name>N1PXW3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_69252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXW3"/>
    <dbReference type="STRING" id="675120.N1PXW3"/>
    <dbReference type="eggNOG" id="ENOG502SN7Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_350259_0_0_1"/>
    <dbReference type="OMA" id="NYYMEAK"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024319">
        <property type="entry name" value="ATPase_expression_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12921">
        <property type="entry name" value="ATP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME47240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="735" mass="83273" checksum="25036213CD6189E7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYU5</accession>
    <name>N1PYU5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_21851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYU5"/>
    <dbReference type="eggNOG" id="KOG3823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009066_0_1_1"/>
    <dbReference type="OMA" id="IRTQFRV"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="11"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME48143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="606" mass="67919" checksum="B616BEDFEE0E3B3A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZA6</accession>
    <name>N1PZA6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_67802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZA6"/>
    <dbReference type="STRING" id="675120.N1PZA6"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_0_0_1"/>
    <dbReference type="OMA" id="DFNRHEH"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME48861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35832" checksum="CB910825D4607A18" modified="2013-06-26" version="1">MELYLIRHGETVDNVAGLYAGVRDSALTIHGVEQARRLGEHFTKNEVTLSHIFASPLSRALMTAQAIQTAQISSGNDQLNIMQAPHLIEQDFGYYEGKTFQARTEAKKSGKESHREKHKDDPGYVDVESKESLNKRADAFLDEHMMPLFAVKSERPRTVVAVVSHGILLSHLWRRLLARFDSKTVTVAPEVIAARGSIVLEHLGGWSNTGYLELVLDSSKPALEMCLAETVAAWTTCADELPALDREKVDRTATTIESVPPSADDSEKTITGSALKGWTMVIRGIDRKEHLTGLKRQRGGIGRSAHDSSQKKLDSFFKRQRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZR2</accession>
    <name>N1PZR2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_32245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZR2"/>
    <dbReference type="HOGENOM" id="CLU_776184_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="357" mass="39379" checksum="36D6D6807D6D0500" modified="2013-06-26" version="1">MDVNARAVPRNSHSFQTTPSSLSGSTMTPWNRAPALLLADDGKQRQRSVTLTAAPPRVPSPSHSIRSHRFDRYGVSTHSTAARRRPLRQQAAQRWRRARQCAEESAGPGALALARARRHATSIFMLHVCYQPACLPACLPAYLPECLPACLNGLACAALAIHPLRHPTVPLCCTLPADGAEVGTTSPRCFMHMLASPTQSEPAVCHLSCPLCSNNMILPQSMQYNQPYFISSLFTDPRPSSTANANNCVTLQHRAQRAPRLNTAAIGRHPPSMASDQLLLSCAHLTALWCGDRPRPSYSPFYTSRSSILRQAQKGTLHLPDVTRAYNAYCRLITREHRHHRQCPRSNTSFNSSPDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZV9</accession>
    <name>N1PZV9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_69756</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZV9"/>
    <dbReference type="STRING" id="675120.N1PZV9"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_5_0_1"/>
    <dbReference type="OMA" id="MCGWDDN"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="339"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="405"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="469"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME47930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="745" mass="85518" checksum="B1E63E30325CD820" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZW3</accession>
    <name>N1PZW3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_167086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZW3"/>
    <dbReference type="STRING" id="675120.N1PZW3"/>
    <dbReference type="eggNOG" id="ENOG502QURC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062644_0_0_1"/>
    <dbReference type="OMA" id="DAGYQHT"/>
    <dbReference type="OrthoDB" id="891726at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="251" mass="28472" checksum="15EA5462FE4DE07D" modified="2013-06-26" version="1">MPAIPPIQHDTSQDPLTLPIRKHKFATPKLRLQLNDLAHEGSSNFLSNIKGNEDLEEQVQNVLNLLYTPDSKRPGTRSVTFIVRDTSGVAYTTGIDLDDDHKEIHINLGYIKSKPRSELLGVVCHELVHCFQWNADGTCPGGLIEGIADWVRLRAGLAAKHWKQDADGKWDAGYQHTGYFLEYLEQRFGPGTVRAINDCLRDCKYDEDKLFGSCCEGHRVDDLWKDYGDHLKKRKRHEDEMVAESAEDMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q176</accession>
    <name>N1Q176_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_30348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q176"/>
    <dbReference type="STRING" id="675120.N1Q176"/>
    <dbReference type="eggNOG" id="KOG3031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049783_0_0_1"/>
    <dbReference type="OMA" id="VGLKPMF"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="5">
        <location>
            <begin position="31"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="346" mass="39014" checksum="A93A999AB2F27130" modified="2013-06-26" version="1">MSLPIKEIKPKNARTKRYLENKGPQNVENPRTTLFLKYTTTSEVLQLVLKDLHSLKRPLCIKFDKKNSIHPFEDASSLEFFADKNDASLMVYGSHSKKRPHALTLVRLFDFKVLEMLELLVDADSFRSLSQFKNAKAAVGLKPLLAFSGSAFESPTANAYTQARSIFLDLFKGPDVTNVDVEGLQYMIHFSVDEEENESVKPQIHMRCYLIKTKKGGGVKVKVDVEEMGPRIDFRVGRTREADPDMWKAAMKKPKMLEVSKVVLGEERHNLTLLQAKTKKNIETDTIGDKVGRIHMGRQDLSQLQTRKMKGLKRSRDVVDNNFDDVEGAASENGGVSLTSGKKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1D3</accession>
    <name>N1Q1D3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_67951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1D3"/>
    <dbReference type="STRING" id="675120.N1Q1D3"/>
    <dbReference type="eggNOG" id="ENOG502SBDS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017360_0_0_1"/>
    <dbReference type="OMA" id="GKTGRNW"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="537" mass="58409" checksum="8FAA6A31366442A4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1J5</accession>
    <name>N1Q1J5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_67436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1J5"/>
    <dbReference type="STRING" id="675120.N1Q1J5"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_7_1"/>
    <dbReference type="OMA" id="FWFPDML"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000318">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="99"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME48374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="551" mass="60967" checksum="983AA7AE162D3B4F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2I0</accession>
    <name>N1Q2I0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_68695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2I0"/>
    <dbReference type="STRING" id="675120.N1Q2I0"/>
    <dbReference type="eggNOG" id="KOG1843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015320_2_0_1"/>
    <dbReference type="OMA" id="SNCKARN"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11842">
        <property type="entry name" value="SH3_Ysc84p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="349"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="408" mass="43342" checksum="CC30229F982A5F10" modified="2013-06-26" version="1">MPLINNPLPSSMRSECKKCGRILASFIDPRQAFGPDKIIPPNILANAKGLAILTVFKAGFLGSGRFGSGVVVARLADGSWSAPSAIGTVGGGFGGQIGFEITDFVFILNDASAVKTFAQVGSLTLGGNVSIAAGPVGRNAEAAGAASLKSVSGIFAYSKTKGLFAGVSLEGSILIERRDANEKMYNRKLTARELLGGNVPVPPQAEPLMRVLNSRVFAGTGGSFQVQDNMYNDVPVYDDRHDDVVWQGRTGTGFNEGIPSQRTGSFQQNNNDEFYGSKPNRASTWQNNDQYGQSSRANPNETFDRLTSSRERSSTLGDQSSYSYSDRKGPAPGRPSAPKPAFGGAKSSAGPGQAVAKFTFEADQPGDLGFKKGDVITIVKRTESEADWWTGRIGSREGIFPSNYVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2J6</accession>
    <name>N1Q2J6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_141977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2J6"/>
    <dbReference type="STRING" id="675120.N1Q2J6"/>
    <dbReference type="eggNOG" id="KOG0217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_1_0_1"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032138">
        <property type="term" value="F:single base insertion or deletion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043570">
        <property type="term" value="P:maintenance of DNA repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000771">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="874"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME48689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1041" mass="116096" checksum="53EDD1DEA185AB95" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2R6</accession>
    <name>N1Q2R6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_143603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2R6"/>
    <dbReference type="STRING" id="675120.N1Q2R6"/>
    <dbReference type="eggNOG" id="ENOG502S268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088665_0_0_1"/>
    <dbReference type="OMA" id="SWRKKQT"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="7">
        <location>
            <begin position="97"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME49528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="186" mass="21205" checksum="D6EA426961DCA62E" modified="2013-06-26" version="1">MQAQSSIPAIESNWLPASLMDKSTQDLHHFLSTPALQHAFLSSPETTHPAVLASEDYLTPIINSNLQLSNNVLTLEQKLSALRSQTQRRLLALRALEQAHRQKISETEDALKDFSPMALYQRLNASVQEQHLLVRGVEESWLEEDGVASDREVVEFVRGVKERRKTALLRRERKGRWDEGRVGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2Y5</accession>
    <name>N1Q2Y5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_19504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2Y5"/>
    <dbReference type="HOGENOM" id="CLU_1547541_0_0_1"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME49025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="173" mass="19290" checksum="51B40971A6ECD833" modified="2013-06-26" version="1">MATAAASLNVTTPYEQKLARRVEDSIPLVGELIDTVHPAMSKQLYQPCRLEDLVAAQDKIEMRRPGEQARTANVLTDPETFVVDMLAMVSSMVDDICALDHTNSIPQLALTWKAPSSTAMTTWQSVDQYRVTLRSWNGESAARIKEHMHWRLGMANAEVFENRLPVLLAARPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3B4</accession>
    <name>N1Q3B4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_163206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3B4"/>
    <dbReference type="STRING" id="675120.N1Q3B4"/>
    <dbReference type="eggNOG" id="KOG3022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_2_1"/>
    <dbReference type="OMA" id="CNHESHI"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001278">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="325" mass="34762" checksum="96BE152C41498833" modified="2013-06-26" version="1">MNASLSLLQVLQLPPAVRCRAADLLLPGRHFSSIRRRNAGHENPLGLPRSGTPPNLVARMKRGLPEKKPIRNVRKVVAVSSAKGGVGKSTISTNLALAMARKGLRTGILDTDIYGPSIPTLLNLEGFEPELDISNRLLPLTAYGVKAMSMGFLVPQDSPVAWRGLMIQKAMNQLLFEVAWPELDLLVLDLPPGTGDVQLTITQSIELDGAVIVSTPQDLALRDAVRGVEMFKKTNVPILGMVQNMSTFTCTNCGHNHDIFGLDGARTKCRELGLDLLGDIALDGQICSDADAGRPTVIAHPESAQAAAFSSIAQALAAKLNLDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4L6</accession>
    <name>N1Q4L6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_49809</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4L6"/>
    <dbReference type="STRING" id="675120.N1Q4L6"/>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_12_1_1"/>
    <dbReference type="OMA" id="DVMIHIN"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000013">
        <property type="entry name" value="Cation efflux family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000010">
        <property type="entry name" value="Cation efflux family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="45"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="360"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME49574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="397" mass="43488" checksum="FF7835403B37BD1F" modified="2013-06-26" version="1">MASPSVQKRTHMGQSHGGHHHHHHHDNTYLTSTNKSDPGVRITRIGLYVNLGMAVGKGVGGYVFNSQALTADAVHALSDLISDFMTLATISYSLKPATTRFPMGYGKVESLGALAVSGILLSGGIMIGLQAVMALSQQFFPQIFELLSQTGIFEHTHHHGHDHGHMDLGPNINAAWLAAGSIVVKEWLYRATMKVAKEKRSSVLSSNAYHHRVDSLTAFVALFTIVASHFLESARWLDPVGGLIISGMIVQAGWGNTKSALYELADVGMDDEAREGAENALQTLLVESNAKVRGVQGIKSGQNLMFEIEVAVPQEWSVSHSNDLEVEIRSAVKQAVRGTRRVNVRFVTLSASHAAFEDQFTKEDRSTINEGHDEQHDHEHDHDHDHARSNGHSEKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2WID9</accession>
    <name>M2WID9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_180645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WID9"/>
    <dbReference type="HOGENOM" id="CLU_1578495_0_0_1"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004028845" description="Secreted protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19333" checksum="0075A584F2991E22" modified="2013-05-01" version="1">MLWVWSGQEAGLDVRIVSFVLWMFCFLQTSTDPRNDRCDRRYTTQTCTFRWRHDDNALLRWSARTPRATRTIAHPSLTSTANRFLQRLRSAGSACLRRRHLHAFAFAQSALAAACSNLRLPFGYFPAARSSIPRGIDNARLHHILASIFHSDIVDFWASTSALILLVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJ42</accession>
    <name>M2WJ42_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PARP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_57293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.M2WJ42"/>
    <dbReference type="eggNOG" id="ENOG502QZBD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261840_0_0_1"/>
    <dbReference type="OMA" id="RAPIANH"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="6">
        <location>
            <begin position="1245"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME38993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1396" mass="155111" checksum="EB62D4647C5C6A1A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJB0</accession>
    <name>M2WJB0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 12 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_92295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJB0"/>
    <dbReference type="STRING" id="675120.M2WJB0"/>
    <dbReference type="eggNOG" id="ENOG502QWKP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079947_0_0_1"/>
    <dbReference type="OMA" id="NAGMEPY"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004028864" evidence="3">
        <location>
            <begin position="19"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME39063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="271" mass="29482" checksum="0EE5A225FEB81879" modified="2013-05-01" version="1">MPSATALTMIAQIAAALALPHHTTLSVRADRAAQNFCGAPNDYAVISGSPWIVYSMNYAYQEIDGSACTGYESLTTASDGTQRIKWNSTWAIAEDSNADVVKGYEFVGLTENLENTITSIDSIPASYQWVKTNTTAYKGNVCFDFMTSDTKGDSTSSSAQELMLWLRYEGGQVPIGYSSGSVATVQLYNKSWKLYQGKNEDTGITVSSLLVDEADQYYGSFEGDIKDWLLAMVDQGLFTTSTYVNVGNAGMEPFYGTVDFKNTLGLQINLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2WLS6</accession>
    <name>M2WLS6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_80537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WLS6"/>
    <dbReference type="STRING" id="675120.M2WLS6"/>
    <dbReference type="HOGENOM" id="CLU_946730_0_0_1"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33351" checksum="DFA39DFE7F206E1F" modified="2013-05-01" version="1">MLCALTASSAYVLELCNTYLQHIFTGEVVVMTPEQTETDTPRAIRYQIMAELYVLRDLLDDTRFRNDVLDSILDLYGTVLNYPSPVATRIAYSKVPKASVLRKLVKDFYTYYLDVEWLESNRNIIDPNFVFDIACARGGGEITQSTHPAEMPPCAYHEHNEEVPECRWWDQAQASGEAERIVLRVQLIVAPPSDAEVSDVVPSKCRYTSVGSTVESKAEAYGTSPTTYTEGTWFSGYNESYRKVDVRDSLTIFVEDQLSYHEATFSYMAELHVHHVPFLPAEGSCRREELPEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2WNI3</accession>
    <name>M2WNI3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_35812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WNI3"/>
    <dbReference type="HOGENOM" id="CLU_2038018_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="121" mass="13054" checksum="D820F651833AA49D" modified="2013-05-01" version="1">MAGPFDFVTIIENTFHAALEGLITSGDARANIASATHEQDADSALKEIQALNTDEFLLPKPTMPALSPRPSSLGHESTMNEVLATNETTNSHTHRCSSRDRRPGQSRKLCLTPKQKPVAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>M2XHF4</accession>
    <name>M2XHF4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_75551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XHF4"/>
    <dbReference type="HOGENOM" id="CLU_2320332_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="99" mass="11227" checksum="9025D3BDE1D8609A" modified="2013-05-01" version="1">MSPSPGQNISQSALLCRRMPPKASATLEVSLHVALQPSPSILQCDPKRVERVVFLSRNQSPQHCQCCRPVLSRQYARDFTDVPFISRGRLFQHCRHVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y0H8</accession>
    <name>M2Y0H8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpL37e</name>
        <name evidence="11" type="ORF">DOTSEDRAFT_75519</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y0H8"/>
    <dbReference type="STRING" id="675120.M2Y0H8"/>
    <dbReference type="eggNOG" id="KOG3475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150908_0_0_1"/>
    <dbReference type="OMA" id="RMAYLKH"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003214">
        <property type="entry name" value="PRK04179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME38809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="93" mass="10451" checksum="135C07EA135BE787" modified="2013-05-01" version="1">MTKGTSSFGKRHNKTHVLCRRCGRRSMHVQKHTCSNCGYPSASIRKYNWGEKAKRRKTTGSGRMRSLKLVPRKFKNGFQSGAPKGARGPTKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y459</accession>
    <name>M2Y459_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_53994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y459"/>
    <dbReference type="HOGENOM" id="CLU_393309_0_0_1"/>
    <dbReference type="OMA" id="AANLECK"/>
    <dbReference type="OrthoDB" id="272761at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="701" mass="78278" checksum="B70119C92D7D2526" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y4T0</accession>
    <name>M2Y4T0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_45265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y4T0"/>
    <dbReference type="HOGENOM" id="CLU_2413242_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="92" mass="10292" checksum="2E621BBCDB653203" modified="2013-05-01" version="1">MNCTTSQTRGTHLACASAATTPANGPRQSASESTMHHRDNSYPIHGSHDSTRPDLHPGLVRRSRMFSLHSLPMVYAVETTYHRSHCRIALWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2YHW9</accession>
    <name>M2YHW9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YHW9"/>
    <dbReference type="STRING" id="675120.M2YHW9"/>
    <dbReference type="eggNOG" id="ENOG502SSKP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_915657_0_0_1"/>
    <dbReference type="OMA" id="GAPECAQ"/>
    <dbReference type="OrthoDB" id="3650766at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004029486" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="29127" checksum="44F885AE894557BB" modified="2013-05-01" version="1">MKHGLVSSTLITLVAASPQWSGPNGGGQGGPLGGFPSCVSSCRDNTDYSDYRNLCDNNDNLNNLNTCVDGSSCSDQEKGEVKQAIVQLCANAGATITAAPFASYSATSGGSAWPTAWTTNSAWASAVSAWNENATGPVGEGWGGSGANGGYGPFGHRGPGGHGWGNGPWESSGAWTSGPWTSWWGTNGCPASTWSGWTDGPWSTAAPWTTWSGCVATTTGSSIYTTTVTPTTGGSAITSVATSFGIRVAEATQDLQSSTVNSDSGAMPTNMAFAGSAAGVVGVVAGAILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIJ9</accession>
    <name>M2YIJ9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_139767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIJ9"/>
    <dbReference type="STRING" id="675120.M2YIJ9"/>
    <dbReference type="eggNOG" id="KOG3574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020502_2_0_1"/>
    <dbReference type="OMA" id="RRKSWIM"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME38736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="60895" checksum="DE33198B98702007" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJX8</accession>
    <name>M2YJX8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_56663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.M2YJX8"/>
    <dbReference type="eggNOG" id="ENOG502TA8A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_250465_0_0_1"/>
    <dbReference type="OMA" id="KSGPRNQ"/>
    <dbReference type="OrthoDB" id="3647859at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="933"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1317"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1415"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1317"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1466" mass="159736" checksum="F028A2B515AD6DCC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2YK66</accession>
    <name>M2YK66_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YK66"/>
    <dbReference type="STRING" id="675120.M2YK66"/>
    <dbReference type="eggNOG" id="ENOG502SVU3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112120_1_0_1"/>
    <dbReference type="OMA" id="MRGFADH"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="170" mass="19229" checksum="8F7ECA67EA6DED46" modified="2013-05-01" version="1">MAAEKIVELTDAELTKVATETAESFVDSFYTALHISRATVGTYYQAAVANEADAKRNLPFVCWNGEAYFSGTEFQKEFDKMPYFFLEVQSLNAHILNPCVSREGKKSHKEAERNVTISLQVSGYVRLFERKDGPMRGFADHIILTANKDTSKAGEGRQWVIQTQNFRFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLE3</accession>
    <name>M2YLE3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_72323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLE3"/>
    <dbReference type="STRING" id="675120.M2YLE3"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OMA" id="KMPLPWQ"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME42831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="289" mass="30968" checksum="F23D15B38269E087" modified="2013-05-01" version="1">MAITGTTVLITGCSENGIGAALATEYQKREYHVFATARNTNKIPKSIASASNVTVLPLDVTSEESIKNAASEVSKATGGKLDILINNSGAAFSGPALDTDLSITRNLLEVNVVGVLAVLQGFQHILASTKGATVVNNSSINGDCNMPFSGVYGATKAATTILSESMRLELAPLDIRTVTLITGIIETNLHANEPEHHLPADSLYKITEEWLGERRKGTNRPPGMSAADYAKQFVDKVERGASGKTYIGPITPMFVYVKWWLPQFLWDFVMMKAGPPNLTEIAGGKNKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLF9</accession>
    <name>M2YLF9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_75373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLF9"/>
    <dbReference type="STRING" id="675120.M2YLF9"/>
    <dbReference type="eggNOG" id="KOG0853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051783_0_0_1"/>
    <dbReference type="OMA" id="EFNTECR"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="2">
        <location>
            <begin position="112"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="326" mass="36666" checksum="64949FE216CF4B7F" modified="2013-05-01" version="1">MPNLVEISKQADPGRPVIFRSHIQIRADLADTPGTPTAGVWEWLWESVKHADIFIAHPVSAFVPSHVNKRALAYMPATTDWLDGLNKEIRDFDNEYYLHEFNTECRRQRMNTLQYPKRDYIVQIARFDPSKGIPDVLASYAEFRRTSEHCRGKKASETPQLVVAGHYSVDDPDGVRVLNQTLELLDGEYSDVKDSVVLMRLGPTDQLLNVLMQNARVALQLSTREGFEVKVSEGLHKGVPVIVTKAGGISLQVQPERSGFIVETGDYKAVAKYLDVLFGDEDRYKEMSKFAASHVSDEVGTVGNAVNWMYLADQMSRGNKIEPNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLQ6</accession>
    <name>M2YLQ6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_101598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLQ6"/>
    <dbReference type="STRING" id="675120.M2YLQ6"/>
    <dbReference type="eggNOG" id="ENOG502R8AX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_6_0_1"/>
    <dbReference type="OMA" id="NDERNAQ"/>
    <dbReference type="OrthoDB" id="3649134at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="41"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="171" mass="19667" checksum="A0EFA8CD98F0EB10" modified="2013-05-01" version="1" fragment="single">FEHQALRTPDHQIRLLHFLRDDQLGLIFQLEAYNVREAPPYAAISYTWGEPGRVQNIVINDDRLEVGQNAHYALWQATVASRGRDVEHYWIDSVCIDQSNLREKSHQVGMMGRIYSGAALVYACVGQHSGTSRSLVHAFDVSSMRDDIIRAMIDLGQRAYWSRLWIIQELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2YN90</accession>
    <name>M2YN90_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_54250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YN90"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="FTHTWTE"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="55"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME43430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="497" mass="54578" checksum="4B2DE021FF82834C" modified="2013-05-01" version="1">MTTESNSASLVEKCHNDFDSSSGTMPEDRDVEATPSLLEDDKQTKRIIRRADLRLLPILAALYSFALIDRTNLANARVAGANEDLGLSVGERYSIVTMMFFIPYVVLELPSNIVLRKIGPGIWLPVLVGTFGVVSMCCGFTHTWTELLGCRVVLGALEAGFYPGCVYLLSCWYIRFEIQKRFSVFYLLATLASGLANVLGYGLSQLNGIGGLRGWRWIFIIEGLATVFVAALGFLIIVPFPDAATKPSLITRKPFLTKEEADIVIARLERDRGDVAEDKMSLQTVLRCCADWKVLEWAWLYLIAATVSYSFSLFLPIILENDLKYSTASAQILSFPPYAVAAPWMFITAWVGDRYRKRGALIIFNCAAALVGLCLIGFASSSPKARYAGCFLGVSGGNSNIPTILTYMHNNIVGQTKRSVASAVLVGASGISGIIAANIFRQQDAPEYKPAIITVIVLNGLSVLHVVKNFYVYARMNRKADRGELVIEGQPGFRLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBX3</accession>
    <name>N1PBX3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_74674</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBX3"/>
    <dbReference type="STRING" id="675120.N1PBX3"/>
    <dbReference type="eggNOG" id="KOG3300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119720_1_0_1"/>
    <dbReference type="OMA" id="YGIREQH"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME39853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="119" mass="13760" checksum="2CC5AD640BCFA2A6" modified="2013-06-26" version="1">MPQDMPPTGGYEPVQYRRNLPVRGFRPAWYLAAVAGVMTYGFYRVGQGIREHNELAREKMWSRIHLIPLLQAEEDRDAVRRHFAQQKMEEELLGKAAPVYNKDVFVRPTYAVTPANVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBZ3</accession>
    <name>N1PBZ3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_47407</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBZ3"/>
    <dbReference type="STRING" id="675120.N1PBZ3"/>
    <dbReference type="eggNOG" id="KOG0739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_2_1"/>
    <dbReference type="OMA" id="IEWTNEF"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990621">
        <property type="term" value="C:ESCRT IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090148">
        <property type="term" value="P:membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036258">
        <property type="term" value="P:multivesicular body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="15">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="163"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="74"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME39888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="433" mass="48054" checksum="5B562734947DB972" modified="2013-06-26" version="1">MSNTDFLGRAIEQVKKAIEMDTAGDYDKAYQQYYQALELFMLALKWEKNAKSKEMIRQKAGEYMERAEKLKNHLAEQDGKRKPAAMGANGKASNGAGKGQNEDDEQDAESKKLRGALAGAILTDKPNIKWEDVAGLEGAKEALKEAVILPIKFPHLFTGKRQPWKGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESERLVKQLFNLARENKPSIIFIDEIDALCGPRGEGESEASRRIKTELLVQMDGVGRDSKGVLILGATNIPWQLDAAIRRRFQRRVHISLPDQPARMRMFELAVGSTPCELQADDYRTLAKYSEGYSGSDISIAVQDALMQPVRKIQTATHYKKVVVDGEEKLTPCSPGDEGAMEMNWTQVETEQLLEPPLQVKDFVKAIKASRPTVSSEDLNRNSEWTKEFGSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCD5</accession>
    <name>N1PCD5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_75867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCD5"/>
    <dbReference type="STRING" id="675120.N1PCD5"/>
    <dbReference type="eggNOG" id="KOG3662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011607_2_0_1"/>
    <dbReference type="OMA" id="TIQNHLC"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="565"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="681"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="608"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME38478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="84248" checksum="502724F7144FFF0B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCL4</accession>
    <name>N1PCL4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_56341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCL4"/>
    <dbReference type="STRING" id="675120.N1PCL4"/>
    <dbReference type="eggNOG" id="KOG3362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034747_0_0_1"/>
    <dbReference type="OMA" id="CCMCGYW"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="5">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME40032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="286" mass="31201" checksum="228845C7472905CC" modified="2013-06-26" version="1">MATGALRFRTPHIEELPIATNRQAPGFTYVAVSGPVVDPSKEWGTTNRKRQRTTGLNQSESQKEALSARQQREVERKIKELNSDSAKDVQIPISKKVETGGGSHRAGKTPGTKKILASGKTFAHYLDDEEAEIARTGRRDGDVEPQAATTQRASKTPLARRKSQREESSMSGSPAPSAPAPPTLIQRQSTSAMTEFTLPEEDSSEADSSIPPLPSQAEIEALLNAPPLTYNQARSAPPPASAPPPRKFCEICGYWGRVKCMKCGNMTCSTHCKDTHDEHKCLKFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDP0</accession>
    <name>N1PDP0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_48581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDP0"/>
    <dbReference type="STRING" id="675120.N1PDP0"/>
    <dbReference type="eggNOG" id="ENOG502SP03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066059_0_0_1"/>
    <dbReference type="OMA" id="VARIPWI"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF7">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="75"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="327" mass="36090" checksum="8638B85C1115372D" modified="2013-06-26" version="1">MVFSTSYWSQYCTTDPFEGKGSIECNHTRQRAKQVRPGSASTGTYLLDQQRCISRTSHICWTVRHTVDMIVLLLGATGNLGSRLVPALLAHGHSVVAYVRSPVKLRSLLPQPILDCIATEQGDAFDTASVANALRRRDCEALVNTAGTRESPWKEQTLGKLVASVITASITVGQERRKPLRSWIVGGMGSLDYPGTDHKIQDYMPAWMTEHHLGTEAVIRGVSVSDVEWSLLCVAMLYPRSDCIELHSRPQKRNLLVATSTPPAWEDHWIRSVPLVGPYLNLVPVIRSYACFLEDVAELLAEDLANDGSPYIGHLVGFKATIHTKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDU3</accession>
    <name>N1PDU3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Hybrid polyketide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hps2</name>
        <name evidence="13" type="ORF">DOTSEDRAFT_157678</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PDU3"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_37_5_1"/>
    <dbReference type="OMA" id="TTFHFFL"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="5"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="955"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2417"/>
            <end position="2493"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="3627"/>
            <end position="3707"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="955"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1103"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2501"/>
            <end position="2537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2573"/>
            <end position="2609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="2511"/>
            <end position="2537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2579"/>
            <end position="2590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2596"/>
            <end position="2607"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="987"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME40768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="4029" mass="438955" checksum="61B6C675909DE92C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEM0</accession>
    <name>N1PEM0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEM0"/>
    <dbReference type="eggNOG" id="ENOG502R94K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1714436_0_0_1"/>
    <dbReference type="OMA" id="QTHDALI"/>
    <dbReference type="OrthoDB" id="3643363at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="157" mass="17299" checksum="268C162DDB573830" modified="2013-06-26" version="1">MADKWEEVFRNLAENTHSITQILDETNEGDELDEKYKEIEAARDAVLKAAKEAPSDIPDFYDDSAQLDLSNAANIPVTACDKLVTALNEKTDIWKEKKDLGKIVKEVVHTNSEVLAKPYPAANPNAPKIMGQTKKAEAESNRLAKAHAKPAEKPADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEX9</accession>
    <name>N1PEX9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asparaginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_178205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEX9"/>
    <dbReference type="eggNOG" id="ENOG502S95P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062004_0_0_1"/>
    <dbReference type="OMA" id="EHNCSGK"/>
    <dbReference type="OrthoDB" id="2588474at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="L-ASPARAGINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110:SF1">
        <property type="entry name" value="L-ASPARAGINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="39374" checksum="2C74FAC51D2ECF00" modified="2013-06-26" version="1">MTLPNTPRDCIISDRGSVIENTHKVHIAIVDSSGELLFSVGDASRVTLLRSAAKPAQALAILETKCFDQYDFNDQDLALVCASHDGEKRHIRRARSILSRIGLTENDLACGSHPSISEAVIQEWYNAHLRPGPICNNCSGKHAGMLAGSLALGAESRGYEDPNHPMQLKVRDVFEQLLAGDDLRWSTDDCNLPAPACSLTAAAKLFVQFAWASDGTYTSNDKTSARRRDMARIFNAMSQYPAMIGGGGGFCTLLTDAYRGALIGKVGADGCYGIAIRESEQTRDLGAEGAVGVALKIEDGNLEALYCAVADVLEQLDIGTKEQRQNLETFHHPRRFNAAGVQVGRMLAAFRLQPTQQDPLLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFP7</accession>
    <name>N1PFP7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_134901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFP7"/>
    <dbReference type="STRING" id="675120.N1PFP7"/>
    <dbReference type="eggNOG" id="ENOG502S9HK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050866_1_1_1"/>
    <dbReference type="OMA" id="GTDQWCS"/>
    <dbReference type="OrthoDB" id="9970474at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518:SF1">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="260" mass="28987" checksum="26F632A64A0439A4" modified="2013-06-26" version="1">MSTTRTSPAVTPPYKTAPAPWTLKGDMFWLILTLKAPLPAEIYDPLTTVRLDQQSNDFQGGIGTIQIIRYDNSPVGPYDELMILPGNFTVPGGDAKGKSKLRIARIYVDSKGSCYNGRRNWNIAKHLARFEWSTSKSGERSVTVFPPDRAGSSSKTPFFSATLTPVSWLPAVPMSTRYLPLDTTLVQPPIPACEEDYLPGTDSWKISRLVASTKRAIVVWMKLNAVGVQDEYWPQVKPWSLGVFLEKGELTIEKPLEFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFS6</accession>
    <name>N1PFS6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFS6"/>
    <dbReference type="STRING" id="675120.N1PFS6"/>
    <dbReference type="eggNOG" id="ENOG502RV54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_603512_0_0_1"/>
    <dbReference type="OMA" id="WFHPYGR"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="454" mass="51718" checksum="F7AE83B375C21C33" modified="2013-06-26" version="1" fragment="single">MKLIWSIPAPLRETIQRFFESNDETDAVDPEDSVGLLNGNEKHHTPPSRLQRDLLNSRNRKAWLYLAFFGIILIFIALAAPTRRVARVELPFMPATAAARPRQEDRFLHIVISQAWSSEASVELCKTVLTASTLGYPTPWSANWNSTLDAEGRDVNTTLNKLEHISTWLSSMPEDRGDDVVVILSNNKSWFQVRPEVLLKRYFAILETGNKELGHHVSADVRDLRDVGEKVVFATQKRCPSKHEASCQGQEAGDKSVHYLSANFAMGSMKDLKTLWQHAAIRATELTARNATLDDHSVFVSLLADQQQYRHTIREQKNHAEDLPAQDEFQDFGIHLDLKNELSYTAALNTDDIEWIKYHNPTKPETRKWISPPDLYLPVDISISAPPLWTIDGTSTPLHNTWHDVQLLTSTSSNTIPAIIQRGHTSRPTLSTTWWEKMWFHPYGRRLLDTFVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFW7</accession>
    <name>N1PFW7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pks2</name>
        <name evidence="12" type="ORF">DOTSEDRAFT_73814</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PFW7"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_31_0_1"/>
    <dbReference type="OMA" id="TFIEEMY"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="32"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="919"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2421"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="919"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1063"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="951"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME41518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="2507" mass="274093" checksum="4A6879D2DDAF1A02" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFX2</accession>
    <name>N1PFX2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Galactose oxidase-like Early set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_134830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFX2"/>
    <dbReference type="STRING" id="675120.N1PFX2"/>
    <dbReference type="eggNOG" id="ENOG502SCD5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013444_1_0_1"/>
    <dbReference type="OMA" id="HDMFCPA"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF56">
        <property type="entry name" value="GALACTOSE OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="2">
        <location>
            <begin position="505"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="63813" checksum="D9C15138F5BD6E21" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG25</accession>
    <name>N1PG25_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial tricarboxylate transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_74890</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG25"/>
    <dbReference type="STRING" id="675120.N1PG25"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_1_1"/>
    <dbReference type="OMA" id="AWYAGCT"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000092">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000064">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter (Ctp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="27"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="114"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="214"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME40236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="33741" checksum="5939A66578F1407D" modified="2013-06-26" version="1">MTTTMPNTGIQAKVPPPTTSTNKSERPSPLRSIIAGSTAGAVEIAITYPAEFAKTRTQLNSRLAQGQKLPFPPFGPQWYAGCTTLIIGNSIKAGVRFVAFDQYKSMLSDAEGNISGPMTVVSGFLAGATESLLAVTPFESIKTQLIDDRKREVPRMRGFLHGSGVISREQGVRGFFKGFVPTTARQAANSAVRFSAYTSLKQMAQSYTAPGEKLGTLSTFALGGIAGTITVYVTQPIDTVKTRMQSLDAKGQYKHSIDCAVKIFRNEGFFKLWSGALPRLGRLVFSGGIVFTMYEKTIELLDNLDPQKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH24</accession>
    <name>N1PH24_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Versicolorin reductase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dothistromin biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_74226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH24"/>
    <dbReference type="STRING" id="675120.N1PH24"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="SIAQTCA"/>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME40606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="314" mass="33147" checksum="8CEDDE3A7C9792DD" modified="2013-06-26" version="1">MTSAAKKRVQALSEHLINRPRSTGTFEDIPTIPTIAGDSKGPRVQGKVIIITGANSPLGIGRATAHHYANNEAKAIFICDLNTDHLETHKREINRLYPGTEIHTKQVDAGDEKDVEGIVNDALAKYGRLDIFFANAGVSVLPKSVLESSADDFMTTMRINALSVFLAIKHGARGMLVTSASKPYPSGSIIGTASSAGLRSNAGATDYSASKAAVVSIVQTTCYQLSGTGIRCNAICPGIIETGMTAPMYEMARERGTENKIGQLNPLMRGGIADEIARVALFLGSDESSYVNGQAWAVCGGLTAGHPFVPGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH28</accession>
    <name>N1PH28_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_73903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH28"/>
    <dbReference type="eggNOG" id="ENOG502S3A7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1570622_0_0_1"/>
    <dbReference type="OrthoDB" id="5398191at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="170" mass="18737" checksum="E7876841B2DE01FC" modified="2013-06-26" version="1">MKARIETASAGETYTEPGSSKAAAKAGEKAADQKKKRTIPGMKSLLSKEGAAAGMLRNTVNFLRVRFPFLASTTNVVMSLAVFILMFVFWYCHKRGKEARLTRAAENEEREAAAGEVEEVDDDGEDIEEEDSDENEEVDQKITDDIEARLNQPAPKDVPLPAEGKDEKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHW0</accession>
    <name>N1PHW0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_35930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME41977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHW0"/>
    <dbReference type="HOGENOM" id="CLU_1777391_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="146" mass="15637" checksum="31567757182FBFE2" modified="2013-06-26" version="1">MGSHPNADVIQCDGDGCETRSVPIPSLSTPSPESPPMMQRFCCPGIAHSMKHDILDDAPLIHFSSNDELLPHRPRVPPKPSHTSEVHASPGQATNLESSVSAKMNVRCNSNGDGPLLENHLTGKASLRNAYVLHAAKVTHHRGDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKB2</accession>
    <name>N1PKB2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_134412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKB2"/>
    <dbReference type="STRING" id="675120.N1PKB2"/>
    <dbReference type="eggNOG" id="ENOG502SQBY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_4_1_1"/>
    <dbReference type="OMA" id="WGVVHSC"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME42005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="277" mass="31493" checksum="7244473F5C1C3E91" modified="2013-06-26" version="1">MLHNVPVNEKAQGYTHEARKLLPKDDVEHNPNRALSQGDKTHSRFFYISFALLNICIGLSIGYLCVRYSTFSVTSWGINPTSPIPKDVFTARQNVAFSPDKRYMGPGHEVNVNWEVLTDADSIYLPDPERYGMHDVGIKAPMFLFDPTPAAAAALPNLNNFYVLNTLHQLHCTNVIRRRYNKLVYDPSATPLAKNPTDEGWIEHVEHCIEYLRLSITCADYMTFESDSPPGSPPEFYEGGLAWGVVHSCVNWDRLMEFQRDQLQLYNSTWNPTGEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL32</accession>
    <name>N1PL32_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_110065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL32"/>
    <dbReference type="STRING" id="675120.N1PL32"/>
    <dbReference type="eggNOG" id="ENOG502SQVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1229714_0_0_1"/>
    <dbReference type="OMA" id="DSKEPRM"/>
    <dbReference type="OrthoDB" id="5416037at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF6">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME42255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="187" mass="21068" checksum="4E54060C6547B5AA" modified="2013-06-26" version="1" fragment="single">PIYRKFEYLNHRILLHLQDELSEMEEHLRQLDEITAQMQPASASGEREPASRRGDAFNGSHIHHQRRELLGRIFLKTEQYNRAIASFAAMTKDSAPAESAKIAAYQGWLKEKAPIHEVEISFLECEKDLIELGKTKPLPPPQLLPDSAYRPTDHTALTCLPAALILPLLLFALIPTLTGRLAVTTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL85</accession>
    <name>N1PL85_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose 5-phosphate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_44156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL85"/>
    <dbReference type="STRING" id="675120.N1PL85"/>
    <dbReference type="eggNOG" id="ENOG502S5ZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_1_0_1"/>
    <dbReference type="OMA" id="YPPFCLR"/>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17102" checksum="708EEBBCFA07418E" modified="2013-06-26" version="1" fragment="single">MSHQGLRIAMGCDDAGVGYKNKIKADLESDPRVSRIIDVGVNDSSDKTAYPHPAVDAAKLIKSGEADRALLICGTGLGVAISANKVPGIRAVTAHDSFSVERAVLSNDAQVLCMGERVVGVELARRLAKEWVGYRFDPQSASAKKVEAINEHERKNFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLM6</accession>
    <name>N1PLM6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pyruvate carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_175540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLM6"/>
    <dbReference type="STRING" id="675120.N1PLM6"/>
    <dbReference type="eggNOG" id="KOG0369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_1"/>
    <dbReference type="OMA" id="KGDAWSI"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007:SF1">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="9"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="123"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="571"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME42460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="71992" checksum="B94351A85A462174" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLP1</accession>
    <name>N1PLP1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLP1"/>
    <dbReference type="eggNOG" id="ENOG502TKCF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_696435_0_0_1"/>
    <dbReference type="OMA" id="VFGACIN"/>
    <dbReference type="OrthoDB" id="3626004at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="44678" checksum="B6A82598A99793F0" modified="2013-06-26" version="1">MPEHPHMCDYTTSRRHMLDNTTEHNAERCRTSLHPESAIMQRSSILVLNDDILVLICDALRPKPSPLLEGQWRYHDPNPLAGLAALSATCKRLRDLVSPSLFRRVKLGRGHWTWDDVRRALTLPPPSRHIQHFTLDIFAHHKDHQGPEKPQPDLELAAALARFLNGLPRLQIIRFTIPDECHELFKEAFQASAIQLSTVKTLRTTWTTQWLVRHCSAVDVLAIDAATARDSGGFPEVLSQTTNLKHLELDTHWNFQDLGSIRKIAPELEVLAISRNVRPYHDAFERMIPTISTFSKLRVLALGSVDQLGVPGLSRRPRCGNAYHGPGGKALRERLANERIVASQTIATNVFGACIELRELWISDYAKYTVTRNGDGSVAHIHMSGERRPKPTEAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLZ0</accession>
    <name>N1PLZ0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor IIIC putative zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_81250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PLZ0"/>
    <dbReference type="eggNOG" id="ENOG502S8BZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_250958_0_0_1"/>
    <dbReference type="OrthoDB" id="6021743at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024764">
        <property type="entry name" value="TFIIIC_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12660">
        <property type="entry name" value="zf-TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1384"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1432"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="4">
        <location>
            <begin position="665"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME42331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1457" mass="161333" checksum="23677327EE0774F0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMB6</accession>
    <name>N1PMB6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_72105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMB6"/>
    <dbReference type="STRING" id="675120.N1PMB6"/>
    <dbReference type="eggNOG" id="KOG1690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_2_1_1"/>
    <dbReference type="OMA" id="GATCAWQ"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109906" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="29"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME44521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="222" mass="25422" checksum="44C6A4CFBF7B6DD5" modified="2013-06-26" version="1">MWSPRSWVSVALLVSQAHALYFYIDGPTQKCFFEELPKDTLVVGHFKATQWNDQSRSYQENRDMGIFITVDEIFDNDHRVVSQRGSSAGKFTFTAADSGEHRLCFTPTNVPATSGFLFSGSQVGGIKFELDLAIGETSQIESSDKDKIGEVVQKVRDLNARLQDVKREQVFQREREMEFRDQSESVNSRVVRWAMIQCIVLALTCAWQLTYLRAFFIKQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PME7</accession>
    <name>N1PME7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_46103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PME7"/>
    <dbReference type="STRING" id="675120.N1PME7"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_1"/>
    <dbReference type="OMA" id="LMVGRQF"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF316">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="85"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME42596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="509" mass="57086" checksum="CB6FB23E95A59FB2" modified="2013-06-26" version="1">MHRHQPAGCLQSACVHQTLWQLRQQLCNLKVGGIRCSRVLRGLTDMLRRYNVSPVQPQLVPLSAGVLVWKPNSVNTHIMIDYLSNVAIVGAGLGGCALAVALSEKNIPVALYESRPEVTDGIPSGVVLPPNGLRILDRLGIFARIKDRCYVPTASVLKNDQDETTEKVPVGGVERWGYKNHRVWRGILLDEMKLMLKARNVPVHYESRFNGIVSETSEQVTFRINDRNVTASLLFGSDGINSSIRKYLAPGVEPEYTGLTAVLGHIKWSDVDWPYSDYERNATIQGKPGAILWIGEDPAGSEIMIVLQKHTPKHSREELARLQADPDRLAAFYTENYDEYGSTAKKIIDAICKRKDSLFIWPFMKMPRIERWYSETGRIILLGDGAHALPPSSGQGVNQALEDVYFVTLLLSSLNQTAAGVNGTNETATLIQALTFWQQERQKRIDAIFDYTNNYTNVNRMPEAERKQMLAEGKVKVKVKGSDNEDMGWLYQPEIDEKVHAWLESRATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMF9</accession>
    <name>N1PMF9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_73472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMF9"/>
    <dbReference type="STRING" id="675120.N1PMF9"/>
    <dbReference type="eggNOG" id="KOG3218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058320_0_0_1"/>
    <dbReference type="OMA" id="VRDRGYF"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="6">
        <location>
            <begin position="155"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME42651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="228" mass="26349" checksum="FC8E8829BC41E31F" modified="2013-06-26" version="1">MSSDEVSRELSRLWRVLRTTKQMCADRGYELTEEECNISLDDFRQQYADETGAPQRTRMAFTARPSENMQKKYMPLQRPGQSEGEPAIGTIHVEFSNDANIGIKHIKQFAQVLSEKNYYTGIFVSAVAPTPAAMKIIPSILPTVMEIFREEDLLVNISKHELVPKHVLLSPEEKKGLLERYRLKETQLPRIRWDDPMAKYLGLRRGQVVKIIRKSETAGRYASYRWCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PML1</accession>
    <name>N1PML1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2 10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_155646</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2 10"/>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PML1"/>
    <dbReference type="STRING" id="675120.N1PML1"/>
    <dbReference type="eggNOG" id="KOG3772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017900_0_0_1"/>
    <dbReference type="OMA" id="HSPQMED"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="373"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="245"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME42691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="561" mass="62869" checksum="2DAB13B5F72574CD" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMU9</accession>
    <name>N1PMU9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_35101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">NZE10</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <title>The Genomes of the Fungal Plant Pathogens Cladosporium fulvum and Dothistroma septosporum Reveal Adaptation to Different Hosts and Lifestyles but also Signatures of Common Ancestry.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Okmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H.A."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">NZE10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMU9"/>
    <dbReference type="HOGENOM" id="CLU_1219675_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="227" mass="25737" checksum="8F62D0B682E47CF5" modified="2013-06-26" version="1">MASKPITPECLGLHLREKDLHALGRAKIRPVRTASGSGYSVLSTKQLDQELACGSTTNSERSTTIGQRPFRILRLPPELQVLTMKGMHRTFLRQESAIRLRPFPCLAQGLSTSRQFFFDNNVICSSSQPVDLYQKRCRRSVLKFDSEVSEEMTALLDHIGHKDVKDIRKIVFLRSEHHCMPHSCRYWMTVLHIKNGLLSDVGFEEEQELELLPNGGLTDSIPVSFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNI9</accession>
    <name>N1PNI9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_130915</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNI9"/>
    <dbReference type="STRING" id="675120.N1PNI9"/>
    <dbReference type="eggNOG" id="KOG0389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_16_2_1"/>
    <dbReference type="OMA" id="IQDKWAA"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033120">
        <property type="term" value="P:positive regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000014">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="396"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="762"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="103"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME43955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="977" mass="108917" checksum="59236BCEB325AA5F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNL0</accession>
    <name>N1PNL0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_72098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNL0"/>
    <dbReference type="STRING" id="675120.N1PNL0"/>
    <dbReference type="eggNOG" id="KOG2375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007072_0_0_1"/>
    <dbReference type="OMA" id="RMQMSAS"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="260"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="993" mass="107607" checksum="22DF4D4A12D65B14" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNM0</accession>
    <name>N1PNM0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNM0"/>
    <dbReference type="HOGENOM" id="CLU_2121015_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="114" mass="12427" checksum="F927B82D418C2465" modified="2013-06-26" version="1">MSHAAGTLPLEYGTLRLGNRLTTKSSSSMEASARERRMSGISAIFHPPTLLSSVQRGTSTSMTTMPNTPSCDRTGRSTPATHDQDTTPSKQRNRPHARNIETLPQKTHHQLSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNP9</accession>
    <name>N1PNP9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_70917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNP9"/>
    <dbReference type="STRING" id="675120.N1PNP9"/>
    <dbReference type="eggNOG" id="KOG2175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004909_0_1_1"/>
    <dbReference type="OMA" id="ALMTHNN"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="144"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="699"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="700"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="781"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="832"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="863"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME45032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="936" mass="104755" checksum="E07A0D1BE1C1EA79" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNT1</accession>
    <name>N1PNT1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_71749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNT1"/>
    <dbReference type="STRING" id="675120.N1PNT1"/>
    <dbReference type="eggNOG" id="KOG2383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008681_1_1_1"/>
    <dbReference type="OMA" id="ARRFINM"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME44045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="62480" checksum="623ED90097B2DCB4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPL5</accession>
    <name>N1PPL5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_71185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPL5"/>
    <dbReference type="STRING" id="675120.N1PPL5"/>
    <dbReference type="eggNOG" id="ENOG502RAAR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1562847_0_0_1"/>
    <dbReference type="OMA" id="TDVACWP"/>
    <dbReference type="OrthoDB" id="3946596at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="171" mass="18754" checksum="82B543CABDB43276" modified="2013-06-26" version="1">MMTDALEIRSPTSLLAPSGRRSSTRTTDKASGSGSPDSPEEGDSSSHGRKVTDVACWPCRKRKGKCTGERPICQSCVRRGYECAYEYDEGLTRVGSLRMRLTEASTRAENLEYLFDHMRTRSDNEAAMLLAIIRLGADLDAIVTRLKSEDDLTWTTAIDPTAADLSGLKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPU6</accession>
    <name>N1PPU6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPU6"/>
    <dbReference type="HOGENOM" id="CLU_1669358_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="158" mass="17421" checksum="7E55BAC853DB2C9F" modified="2013-06-26" version="1">MLMSCRCVAEIEDAVLGKAEVHSTLCCRLFVSALSAPFAIQSHYTMKHASRRVPRSGCGSVPGNVWHRHDEKMCKTRALRSRNREGGSLRAACCCSPKATPPAKSHHTISTPVHRWIDRGGTSDHVGLAALVDSMSSRMRIEQPALRRAKKMRCQTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPV0</accession>
    <name>N1PPV0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-terminal of MaoC-like dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_150445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPV0"/>
    <dbReference type="STRING" id="675120.N1PPV0"/>
    <dbReference type="eggNOG" id="ENOG502S5QU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028690_0_1_1"/>
    <dbReference type="OMA" id="IHYDRRY"/>
    <dbReference type="OrthoDB" id="3257538at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000103">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF2">
        <property type="entry name" value="N-TERMINAL OF MAOC-LIKE DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40418" checksum="22D1C0780CE49905" modified="2013-06-26" version="1">MARPVLSSVTRAGRRAAVPGRSSTSSNARPFHASTTLLQQKPEAIAEAFLSKFANGKEFVRKQLLDANQLRLLSLTLDRTKLWPGLESLEYSEPAEGTPLPAGYHNAYFTPTQLPDALGVDGTDTSYNPEAPFTRRMWAGGSIHWPGADPSASSQSYLKVGDIATEVTKVKSCEVKTIKKTGEAMLVVGVVKEFLDSKDNLCVTDNRNWVFREALDPSKKVKGPQKPPEPTMDELKRADEGKLVRHFNRDPPTLFRFSALTFNAHRIHYDKPWSVEVEGHRDTVVHGPLNMLSMLDFWRDEDSGIAGKDILLPKSLKYRATSPVYVGEGYRILIEKDAIDKGEVPIEVVSNDGTSCMKGTIERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ34</accession>
    <name>N1PQ34_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_24558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ34"/>
    <dbReference type="HOGENOM" id="CLU_1180192_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="235" mass="26061" checksum="376FCDC443D7E9A0" modified="2013-06-26" version="1">MALIKLSIETPCQIAIELNTNDYSSSRLACRTTSRIGFETFAKNYFSVLLRLVEDPSALAKFVTSLEVHFPSSHKPKKDAQAYQEVRISQARPLLVAPLRNIIDGTPSLQNVDLQSRTCCPSSTGGWISVLEHLEAREASGLRALRLADLKDTEDEVVGTGTWEVGTRPEPQWLGLLGEPFMLDVARPPLEYMRTSTGIQYYQLGNQSSWVQGRDGIKAGLEIVVLGRPRESDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQJ7</accession>
    <name>N1PQJ7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_72229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQJ7"/>
    <dbReference type="eggNOG" id="ENOG502R1TU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028280_0_0_1"/>
    <dbReference type="OMA" id="SAIWNFT"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF7">
        <property type="entry name" value="4,4'-DIAPONEUROSPORENE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108962" description="Amine oxidase domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="53354" checksum="3FD1A7561FC8D748" modified="2013-06-26" version="1">MLLPRSPYLASLALQVITTFASPTSSANATIETIDRDVVVIGGGSSGTYTAIRLQQLGKSVAVVEKQNRLGGHVNTYVDYFTNTTFDYGVIIMVNITVVRDYFAYLDIPMGTFQGYVPNQQTLYADFASETNVSTMYNDAQVAAAVLGYAAQLEKYSYLSSGYHLPDPIPKDLLLPFGTFLEKYNLTALAYTIWYINEGAGDILAQPTLYMLKYFGLLQAQGLAGVSGMQFVNANNDYQSLYNSALTHLGEDTNAFLDSVPTNVHRNDTGVSVRVATPTGEKLIRAKKLVVSIPPKIQELAPFLDMTSNEQALFSQFNNSFHYAVVVGNTGFPPDALIENLNPKAPADLPPMPAAYAFAPTPVEGLHIVWCGTSHYEPVAQIKTAILEAARAVQRTYNYTSPEAGGPKIIQFRDHSPTQLEVSVEAIKDRFYDKLNALQGDMNTFWTGATWESHSSSAIWNFTEYEVLPKILESVIHMDWLCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQS1</accession>
    <name>N1PQS1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_44888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQS1"/>
    <dbReference type="eggNOG" id="ENOG502S8X0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110355_2_4_1"/>
    <dbReference type="OMA" id="ESGNWKM"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="107" mass="11830" checksum="4E29E48F75EEAB09" modified="2013-06-26" version="1">MGKQEWMVILPDVPGKLEERMKVRPQHLEAIGPRVQAGQIVLGGASLDEPVKEGSPIKINGSVLMAEADTEEEVRKIVESDIYYKSGVWDAAKIQIFPFKSAVRKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR36</accession>
    <name>N1PR36_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_130363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR36"/>
    <dbReference type="STRING" id="675120.N1PR36"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="OMA" id="MLRINIC"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="19"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="229"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="306" mass="34918" checksum="393E588BCBB39D38" modified="2013-06-26" version="1" fragment="single">MFIRSETPEPTSQLDPDVYAILSHTWSQDEVTFKDMTHLPTAERRAGFWKVRRCCEQARSDGFQWAWVDTCCIDKSSSAELQEAINSMFEWYANAAHCYAYLPDVDIDADATADKAAFMNSRWFSRGWTLQELIAPKTLTFYGNGWSRLGPRTELSWLIAKRTGIPEGLLGADPISRDSRRQRSVDHYSIAQRMSWASGRQTTRIEDRAYSLLGLFGIAMPMLYGEGRRAFLRLQEEIVRTSRDLSILAWERPSIPIDHIDSMGHDDDSLQSLLAPSPDFFSECGDIIFYETKQALQSSIERTVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRU8</accession>
    <name>N1PRU8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRU8"/>
    <dbReference type="STRING" id="675120.N1PRU8"/>
    <dbReference type="eggNOG" id="KOG4391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043841_1_0_1"/>
    <dbReference type="OMA" id="CFWIVVM"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF64">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45251" checksum="FB0030F18C5124DF" modified="2013-06-26" version="1">MPAWSHGAGLPVHITISNAFLRPAFDQSQSLRCSTDRQYSYVLCRRSIRTLQWQSRTFHSPIRRSFVTDSLPSILVPPVVFTGLLIGLWTYKCAMTVIFQDKIIYMPYMPPFARSEKMEDYAASCKPVEWEQRHIESIDGTRIAICIGMIAPIETRRPVGAAKRKHVVVCYFQGNGSSPPPRLPLLSNVLKSVHAQTVGLTADVQYIIVALSYRGYWTSSGRASQAGIELDAKALLQWVTSEYSADDIDLQIILWGQSIGAGVASTAAATYICNSKTLDGAPINGLVLETPFTGIKSMLLALYPQRWLPYQYLWPFLWNFWDSEAALRRIAESARKPKVLLLPATKDEVVPPSEVDKLECICHDVGLITQRKNVMGALHTEATTRREGQEAVAKFMIEVAEADRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRV9</accession>
    <name>N1PRV9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_168591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRV9"/>
    <dbReference type="eggNOG" id="ENOG502QR14">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041456_0_0_1"/>
    <dbReference type="OMA" id="QFFGQHY"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000021">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="140"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME46201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="260" mass="28537" checksum="251C1A0FBE3F870A" modified="2013-06-26" version="1">MAPKGKAAKKSNRSAMTTAAAKKSPLPEWPHMQPLIPSEDLALDVLLQDQILVIPRLWTSGRCKAYISFLSGLALTTTPGNAKKGDALRVNDRFQVEDPNFAEQLWSGTALKDLVSKAAIDGVELSAVAKHELWGGEVLGLNSNIRIYRYSKGQFFDQHYDDSNNVTFSSPTFPDSVSAKTTWTLLLYLSSPATGCKGGETVFYPEPSSKREAAPPPVIASLEVGMALLHRHGKDCLLHEGREVTEGEKWVIRSDLCVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSR8</accession>
    <name>N1PSR8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_52734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSR8"/>
    <dbReference type="STRING" id="675120.N1PSR8"/>
    <dbReference type="eggNOG" id="KOG4463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057574_0_0_1"/>
    <dbReference type="OMA" id="RYRQFWR"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME45464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29948" checksum="39CC6B40BB83650F" modified="2013-06-26" version="1">MLASGFTNAPVTKLLVAAVVITSFLASLTDTKYYFWIDVRPHLLDYWQWWRLFTWQLCYTNSTEVFFATVVLYNLRVIERLWGSRKFASFILSTFLYNAILPPILLTLVIRPLSLGRINYLPAGPTPLVFSLLAQYHAAIPYIYKYRVSIGLSTGDNGLMLTSKATSYLLPAQLALAQLPGSALAAALGWIVGFAYRRDILPGATTWRVPTWLISGGDATRKERFNTMRRRMEGEVGQATGVDARPEGAGEGRRRGVLGGLADQFRGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSU5</accession>
    <name>N1PSU5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ArsA/GET3 Anion-transporting ATPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_70121</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSU5"/>
    <dbReference type="STRING" id="675120.N1PSU5"/>
    <dbReference type="eggNOG" id="KOG2825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040761_0_0_1"/>
    <dbReference type="OMA" id="MDAPYEF"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="11">
        <location>
            <begin position="19"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME46008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="334" mass="36640" checksum="02FA2AC1B3C7107E" modified="2013-06-26" version="1">MADDMAPSLQSLVDQKSLKWIFVGGKGGVGKTTTSCSLAVQMARARKSVLLISTDPAHNLSDAFGVKFGKDAKPVPGVEGLDAMEIDPNGSISELIKSGGDDAQDAMAGLGGVGNMFQDMAFSIPGVDEAMSFAEVLKQVNAMKYELIIFDTAPTGHTLRFLQFPTVLEKGLGKLMQLSQQFGPMLNNLIGARGGLPNGQSFDDIIGKMKELEKTISDVNKQFKNAELTTFVPVLIPEFLSLYETERMIQELGSYEIDTHAMVVNQLLFPKKDNPCDQCNSRRKMQKKYLEQIDDLYGDDFHVVKMPLLTEEVRGVESISKFSEMLITPYQPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT21</accession>
    <name>N1PT21_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_70172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT21"/>
    <dbReference type="STRING" id="675120.N1PT21"/>
    <dbReference type="eggNOG" id="ENOG502RBAK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013400_1_0_1"/>
    <dbReference type="OMA" id="QPQMATS"/>
    <dbReference type="OrthoDB" id="7295497at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF19">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="556"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="632"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME46088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="709" mass="78052" checksum="CE09EF189C6E7CBA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTD5</accession>
    <name>N1PTD5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_70659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTD5"/>
    <dbReference type="STRING" id="675120.N1PTD5"/>
    <dbReference type="eggNOG" id="KOG3662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021690_1_0_1"/>
    <dbReference type="OMA" id="GLKEQNH"/>
    <dbReference type="OrthoDB" id="9984693at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF1">
        <property type="entry name" value="PROTEIN TED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="156"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME46731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="518" mass="58462" checksum="1E09FD98FC281B0A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTE1</accession>
    <name>N1PTE1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTE1"/>
    <dbReference type="STRING" id="675120.N1PTE1"/>
    <dbReference type="eggNOG" id="ENOG502RXMD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015562_1_0_1"/>
    <dbReference type="OMA" id="CNHANDQ"/>
    <dbReference type="OrthoDB" id="10261749at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="54128" checksum="1A10CB7110A1B0A6" modified="2013-06-26" version="1">MVKPRLIILIRHAQSEGNKNREIHQMIPDHRVKLTEEGHKQALDAGRRLRALLRPDDKLQIFTSPYRRTRETTEGILKTLTSRDDDEAPSPFSRNKITVYEEPRLREQDFGNFQPCSAEMERMWSERADYGHFFYRIPDGESAADAYDRVSGFNESLWRQFGDMDFPSVCVLVTHGLMSRVFLMKWYHWSVEYFEDLRNVNHCEFVVMRKDAETQKYILENKLRTWSELRRQRKEQQARQDPQRRNTLSSFLTQSQQSPQIPPRKWGGCSDGCNHANDQYPRRTAQRKQQVQQELQLPPAAEAPEGIPSGVQDHPVARVELTAKRGEDLASVDGPSDEGSTTISRPGFKVPFRPAADTYLNPGRDGGGTTSGTTTPHEMSEIDGGQYFSHQTQKETALSSALRKAPQRKATPEDIERWAQESGMGKGQKADALGDEPEAWSDENRGSLDGSNASQGMNDLDRAEKEDKGLRGSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTR8</accession>
    <name>N1PTR8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTR8"/>
    <dbReference type="HOGENOM" id="CLU_2573855_0_0_1"/>
    <dbReference type="OrthoDB" id="10385347at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="81" mass="8931" checksum="FAC6CD4282202452" modified="2013-06-26" version="1">MDPDVQFIVAAIAQYGSRRPQRYVQHWVILGQVTVQDNGDNQVMVLTLGSRSIDELDAVRRGCRADEVVGTAALRSSFAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU64</accession>
    <name>N1PU64_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_102800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU64"/>
    <dbReference type="HOGENOM" id="CLU_2928928_0_0_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="61" mass="6661" checksum="78C69DD1FA0C5E98" modified="2013-06-26" version="1" fragment="single">FAFEKSASSRYIGQDYDIIIIDTSAAGCVFAARLPEDPNISILVLGAGGNRNDYERVYYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU83</accession>
    <name>N1PU83_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_149481</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU83"/>
    <dbReference type="STRING" id="675120.N1PU83"/>
    <dbReference type="HOGENOM" id="CLU_994057_0_0_1"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME46947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="282" mass="31308" checksum="903446633F1FAAC9" modified="2013-06-26" version="1">MDEDDFTTWEADMADEPRVDDDLCAAVRIGRIHGVQQAVEDLKVYDGWPILLSRALVSSIETTNFPALRFLLSYAAVDGEVAEAAAISENISIVQIILDHGWPINRALRGGMVPSILSLAIHNVQFLEKLLELGADPNAESNLGDTALSFAIREGTMNVVKRLIATGSDVTRGDLLHCASRREPSEDIYDLVPMLVEAGTPIDTYQWDNERAKSLRYGFPQGTALHRACEEGNYPAADALLRHGADPHRLKKKKEHLCPPSPLEITKTRPRPKMRRLLETYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUP1</accession>
    <name>N1PUP1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_70193</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUP1"/>
    <dbReference type="STRING" id="675120.N1PUP1"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="OMA" id="FMTPGDI"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08283">
        <property type="entry name" value="FDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="68"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME46109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="448" mass="49534" checksum="D0CAC02A4BF221D4" modified="2013-06-26" version="1">MALSQAAAKAEQYIGHDDNATTEQNLTNPDRDRKKYADPSGEKMQALAWMGKNTVEMIECPKPRVIEDKDVILKITGSTVCGSDLHLLHGTVVELEKGDILGHEFCGVVDDVGPAVTKVKKGDRVVASFQIACGECYYCKQKLSSQCEKTNSNTIENAMYGGRTAGMFGYSHFTGGFAGGQAEYTRVPYGDVNLLKLPDDVPDEKGLYLSDVISTSWNCVVDTGVKEGDVVAVWGAGPVGQMAAEFSFLHGASRVIVIDSNWRLDYMKEKYPKVETVDFSQLKGTKAVVSKLKEMCSNRGPDVALECVAGEYPKGWFHATQMALGLETDTSEILNEMIESVRNFGRVGITGVYVGYTNNFNIGSIMERGIRFIGNGQAPVHLYWEELLKRIQSGEIDPLKMVTHRVDMEDLAKVYYKFEKKEDHMQKVYVQTKFSAPPCEGSPALTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUP5</accession>
    <name>N1PUP5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_108081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUP5"/>
    <dbReference type="STRING" id="675120.N1PUP5"/>
    <dbReference type="HOGENOM" id="CLU_2580248_0_0_1"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="81" mass="8781" checksum="D2DAAEB50D2C007A" modified="2013-06-26" version="1" fragment="single">FEVNVFGLLKASKAVFSLLRALEGTVVNQSPVAGYYRMRQPFLKSCSASQISVMAINNTLQVELAPFDVKVVTLSTGNVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUP8</accession>
    <name>N1PUP8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein Rad26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_123847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUP8"/>
    <dbReference type="STRING" id="675120.N1PUP8"/>
    <dbReference type="eggNOG" id="ENOG502RZ1G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013058_0_0_1"/>
    <dbReference type="OMA" id="EMAHEML"/>
    <dbReference type="OrthoDB" id="5245063at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048379">
        <property type="entry name" value="Rad26-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022093">
        <property type="entry name" value="Rad26-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048380">
        <property type="entry name" value="Rad26-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21046">
        <property type="entry name" value="Rad26-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12331">
        <property type="entry name" value="Rad26-like_helical_rpts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21048">
        <property type="entry name" value="Rad26-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad26-like N-terminal" evidence="4">
        <location>
            <begin position="277"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Rad26-like helical repeats" evidence="2">
        <location>
            <begin position="381"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Rad26-like C-terminal" evidence="3">
        <location>
            <begin position="613"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME47102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="78435" checksum="483FD36FDFCEB4D4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUQ3</accession>
    <name>N1PUQ3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_148087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUQ3"/>
    <dbReference type="STRING" id="675120.N1PUQ3"/>
    <dbReference type="eggNOG" id="KOG0429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040072_0_0_1"/>
    <dbReference type="OMA" id="DGIWAKR"/>
    <dbReference type="OrthoDB" id="5596422at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="8"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="303" mass="33268" checksum="070F071BA6998A53" modified="2013-06-26" version="1">MPLQSAAFVRQKLCVDFASLKHACPKGIYVAPVPDEPLIWKGVLFVRKGPYANAVLRFQINFPDDYPQRPPVVTFQSDLFHPLVTPLTTYTHSTISTDTQSAVDEQRLPPGGLSLRHGFPEWLGAADEVAIETGVAQPQTRQAEHDGEQGQHTDATVKDQRAPHIVELLHYVRIVFDTQEMLDAVPLNAAANTGAWHAWRSFRTKAPAGSRGASVARSLGDGMATSIERSVSPRQQPGGARRPGEWNWQGVWEERVRRSVQTTLSEPVLFGGDSDDVISFLKMDQQAVSQISPMKQAAAATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV54</accession>
    <name>N1PV54_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pex N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_78963</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV54"/>
    <dbReference type="STRING" id="675120.N1PV54"/>
    <dbReference type="eggNOG" id="KOG2879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024591_2_0_1"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF4">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="16">
        <location>
            <begin position="274"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="613"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME46828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="677" mass="77062" checksum="9ED9F9F3CA647313" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVP4</accession>
    <name>N1PVP4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="14" type="ORF">DOTSEDRAFT_69107</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVP4"/>
    <dbReference type="STRING" id="675120.N1PVP4"/>
    <dbReference type="eggNOG" id="KOG2420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029061_1_1_1"/>
    <dbReference type="OMA" id="HSPASWV"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023277141" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023277142" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="524"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="86"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="309"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="523"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME47013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="580" mass="65243" checksum="63D5E867650B12BE" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW01</accession>
    <name>N1PW01_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_146488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW01"/>
    <dbReference type="STRING" id="675120.N1PW01"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043304_1_0_1"/>
    <dbReference type="OMA" id="WMRRKKD"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="5"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME47661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="349" mass="39565" checksum="24DA01AA63E62C57" modified="2013-06-26" version="1">MADSVDRVFGHALNTVNKIRPGSQKPPSADRLALYGLYKQSMEGDVAHVADRPSSSPATSSEQLKKEQEQWDAWKANEGLSRTEAKRRYIEKLISTMHKYASTTTEARELVEELEFVWDQIKNNSQHSSSEHSSPLQTTERRDYMHSGGNSGNNGGVSSSAAALESAGKDRNKGLQVLSPQSEVDEDEAAEDEREEFVDAPISQIDEADLQEPSEPEHDASSPHRFVAPRRPLPSAAENRWRRRVESSLIRLTTEITALREQLESRRWLNYQRKHSWLGWVLRLSWWAVQLVLADAAILWVVILYMRRKQDRRLEGAVRVLLGDAVAQVQNLGTQVKIPAMPRIRKPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW96</accession>
    <name>N1PW96_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TRUD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_114770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW96"/>
    <dbReference type="SMR" id="N1PW96"/>
    <dbReference type="STRING" id="675120.N1PW96"/>
    <dbReference type="eggNOG" id="KOG2339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005281_0_0_1"/>
    <dbReference type="OMA" id="WINYFGH"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="370"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME47248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="752" mass="83256" checksum="89FC13BA365C55F3" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWP9</accession>
    <name>N1PWP9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_33201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWP9"/>
    <dbReference type="HOGENOM" id="CLU_1731421_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="151" mass="16781" checksum="EB6E76320A46DAEC" modified="2013-06-26" version="1">MYMPYELGRNTDSKGHPTQYLLPNGGPYTCKLESWHWYDGALRDGRLEMVYQLCHAEPCEVVWLLISEVPARSFAVPRVPRICDTIKLNCVSASLHGPLLIVTSPLIPLSPKIRPSFYSSPPIDDGREHYSKAPLVKTQHIAAEAAAAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXS9</accession>
    <name>N1PXS9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXS9"/>
    <dbReference type="STRING" id="675120.N1PXS9"/>
    <dbReference type="eggNOG" id="ENOG502RSVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015848_0_0_1"/>
    <dbReference type="OMA" id="YIAHYHR"/>
    <dbReference type="OrthoDB" id="3365211at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="73209" checksum="DF753EF76C2B034F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXT4</accession>
    <name>N1PXT4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_146789</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXT4"/>
    <dbReference type="STRING" id="675120.N1PXT4"/>
    <dbReference type="eggNOG" id="KOG2360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_7_4_1"/>
    <dbReference type="OMA" id="SFKSRIY"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="141"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="248"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME47808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="565" mass="61896" checksum="BFCB2F94B8845F8C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXV9</accession>
    <name>N1PXV9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_166117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXV9"/>
    <dbReference type="STRING" id="675120.N1PXV9"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_9_1_1"/>
    <dbReference type="OMA" id="HCMARLM"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="364"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="6">
        <location>
            <begin position="457"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="461"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME47235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="600" mass="67592" checksum="B2F16492B1648A0A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY38</accession>
    <name>N1PY38_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7923 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_29815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY38"/>
    <dbReference type="STRING" id="675120.N1PY38"/>
    <dbReference type="eggNOG" id="ENOG502SJHR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415059_0_0_1"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="2">
        <location>
            <begin position="440"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="661" mass="74195" checksum="2116D9A9198445F4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYA5</accession>
    <name>N1PYA5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_67517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYA5"/>
    <dbReference type="HOGENOM" id="CLU_2722197_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="72" mass="8450" checksum="EBC1FC99F0062717" modified="2013-06-26" version="1">MMLDVYTVEVEDKTRQHRKIDRQHSKSVRQHVLARSRHRHQTWRATSIIILINIINRLEASSECAWACGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYL0</accession>
    <name>N1PYL0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_67528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYL0"/>
    <dbReference type="HOGENOM" id="CLU_2026668_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="122" mass="14058" checksum="649123FDC523B62D" modified="2013-06-26" version="1">MFYRPRERASQTQRDGTKCEDVRRFFGRTRSGRYPTWVLQTFDNETSENNARMRDTTHQELYPPYDVHGAVSSKQPRIQPFQRHYEAILSHTVKIPGHCADSGSAPGARPGCLEKHSQIGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZ31</accession>
    <name>N1PZ31_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">biotin synthase</fullName>
            <ecNumber evidence="4">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_67652</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="4"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZ31"/>
    <dbReference type="STRING" id="675120.N1PZ31"/>
    <dbReference type="eggNOG" id="KOG2900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033172_3_2_1"/>
    <dbReference type="OMA" id="NICTTHT"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="95"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME48682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="411" mass="44829" checksum="D7815AB1EDD8082B" modified="2013-06-26" version="1">MALALLLRRAAVRSSQISRAGYLRSFSTPINDSFSPISATSPPPPEGSNALWSAVNARTPRFNWSKDEIREIYHTPLMELAHQAGVLHRRFHSPSAVQMCTLMNIKTGGCSEDCSYCAQSSRYNTGLKATKMSPVDEVLEKARIAKNNGSTRFCMGAAWRDMRGRKTSLKNVKAMVEGIRSMDMEVCVTLGMIDQNQADELKAAGLTAYNHNVDTSREHYPSVITTRSYDERLQTLENVRQAGINVCSGGILGLGEEPEDHVGLIYTVSTLPAHPESFPVNALVPIKGTPLGDSNKKRIEFDAILRTIATARLVMPATIIRIAAGRTTMSEAEQILCFSAGANAVFTGEKMLTTDAVGWDADKEMFHKYGLVPMKSFERGGYRETSWSALKTEAAASPIVEGAASQQTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZB0</accession>
    <name>N1PZB0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_69605</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PZB0"/>
    <dbReference type="eggNOG" id="KOG4626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001721_0_0_1"/>
    <dbReference type="OMA" id="GFRDRWH"/>
    <dbReference type="OrthoDB" id="421121at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000180">
        <property type="entry name" value="Related to UDP-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000552">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000004">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000110">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="570"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="927"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="961"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1160"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1423"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="313"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="367"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="635"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="635"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME47710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1653" mass="182528" checksum="83AC0E79A9DD2A2C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q054</accession>
    <name>N1Q054_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_142792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q054"/>
    <dbReference type="STRING" id="675120.N1Q054"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_4_0_1"/>
    <dbReference type="OMA" id="TYIRNSH"/>
    <dbReference type="OrthoDB" id="3905365at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="194"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME49121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="356" mass="40424" checksum="54D31AC28045EEC7" modified="2013-06-26" version="1">MPHAEERSEFTPEQYPPFPDSPEFPTIDLETISLAKLQQSDPTELNRVFEACKSWGFFYLELPGCEQGDLIVNGADGICRVAEKTFHLPLDEKLKYEFTGKDIFGYKRVGRTVTDKNKTPDTAEFFNVAKNDMIVDDDEMRSQWPDIVKENKPLFRKYQIAAHSIGMQILDVLAQKLGIDPQELHSRHELGKLAGDHVRMTRGPPRKSTEMPEIQTPSHTDFGTITILVNWLGGLQVYATPNKVLGNLSYNDDEEGSWRWVKPKKNCAIINLGDAAVKFTNGVLCSGRHRVVPSPGEQGKWPRYSIVYFVRPNDDCNLKPLRGHGVPESEEQNEEGVNAKEWIFMQAERLRTGYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0U3</accession>
    <name>N1Q0U3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_67831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0U3"/>
    <dbReference type="STRING" id="675120.N1Q0U3"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025506_1_0_1"/>
    <dbReference type="OMA" id="EVWVFDQ"/>
    <dbReference type="OrthoDB" id="2115716at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF132">
        <property type="entry name" value="ATP-DEPENDENT ZN PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="232"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="497" mass="56596" checksum="1DF02FCF94724184" modified="2013-06-26" version="1">MTKTSAGAQAQQQRNHPPARPQAPDQVPSALLKHSSAQRTDTDVIIVDAIRKEYSQLHLTVVPSIRCDILAYASAGHAGIAPIDTEKEHLSWRQYLAPSSRLSGRGVLVDDVKYGKYLLDWKNKEFVIYVIDGRDGNYPFGVQRNQYVLSSSVQATNELLLEAGQYGNLLHDEVWVFDQGYWQKSADLWESVQKARWEDVILKPEMKKLIKDDVLSFFDSRETYEKLRVPWKRGIIYFGPPGNGKTISVKALMNTLYKREDPVPTLYVRTLSSFAGPEYSLGQIFAKARATAPCLLVFEDLDSIVTDQVRSYFLNEVDGIKKNDGILIIGSTNHLERLDPGIVKRPSRFDRKYEFRNPDEGERVMYLKYWQGKLSDNHDLDFPDKLCPAVARITKGFSFAYLQEAIVAALLTIARDDDTFSGRTCLECMQSHAAPQNSSSCDRQSVRPFKGLYDYVWLAKQVEDGDSSLDNYVLWREIKKQVRILREEMGDEDSVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q188</accession>
    <name>N1Q188_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_18941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q188"/>
    <dbReference type="HOGENOM" id="CLU_1722327_0_0_1"/>
    <dbReference type="OMA" id="ESESCKQ"/>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17624" checksum="06953C1599A02251" modified="2013-06-26" version="1">MASTTTTSTSQNETASLQSTQCHLLKLPAELRLEIYELVLANLDIGYSLQREYPSILQVCKLLRHEAVAIFNKRLSAALARYKAQVEIARAERHRSEKKYNEQRERLMGVPSLETLLDAINACDVFSAILDDYTGVRRVVQRERTKLRLEGFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1G4</accession>
    <name>N1Q1G4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_48843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1G4"/>
    <dbReference type="STRING" id="675120.N1Q1G4"/>
    <dbReference type="eggNOG" id="ENOG502RYYW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012943_2_1_1"/>
    <dbReference type="OMA" id="CCYWSPA"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME48324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="706" mass="79820" checksum="2AD4D79C71BB50F0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1W6</accession>
    <name>N1Q1W6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_76908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1W6"/>
    <dbReference type="STRING" id="675120.N1Q1W6"/>
    <dbReference type="eggNOG" id="ENOG502T6B6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_806590_0_0_1"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="133"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="344" mass="38115" checksum="C1C4E5DFB77AE190" modified="2013-06-26" version="1">MLRRKALLKRLRTTTTSKTGASLERVAASTTVDRPILGGTTASRIGKAVIEPRYAQSVGSAPGLLSTRTLQPIFVSPPTRDTYIDDAKHLAPRKRTILRRRRTSQRSTSEVRVLSRQGDIRQLRSYLQHEDVVLIAIDTESERQGLLNHVVEVGLSVLRTRDIHNVKPGAHVKNWIAKVRHHHIVIDVTRHPRRRMRGSRFGRSLFLSPGDAKDELLAIVKSSLADIGTDSIAFVGHSLGNDIQAVLQSPGLATDLLDISRPGHAVFDTFTLATAAEREGARIPKKSLSGLARCLQVDPRYCDENGAVIGWHNASNDAAYTMMVLLLYGAHWQDLKIVYGKRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1Y6</accession>
    <name>N1Q1Y6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1Y6"/>
    <dbReference type="HOGENOM" id="CLU_2960709_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="59" mass="6405" checksum="DB67ACFA6098F7C2" modified="2013-06-26" version="1">MSIHGHIVTGGTIKKQNRSYGRSRSARPAGMSRAIPPSRPRAATIGPARRYHIAMHAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2G1</accession>
    <name>N1Q2G1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_49229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2G1"/>
    <dbReference type="HOGENOM" id="CLU_1402393_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="194" mass="21849" checksum="3485F16FD08B9EA2" modified="2013-06-26" version="1">MHPKQEQYSRSLLTRVKQNSIDMLAILDLDIVQLPRYGILLEPAQHLDALSDADKLDILLYTLDSTMAGDTSHLLERILGSEALSSSTMSLERSDWMSLTHILAFAHATEVVAKLTDDGCSRSASPTLIRYLRQCAVAKAPSHHVWFQERWHLLPHHAVVSLHPQLVMLGSWVNEQDCDLADAWTFFSGRYKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2J0</accession>
    <name>N1Q2J0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_67649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2J0"/>
    <dbReference type="HOGENOM" id="CLU_1245317_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="222" mass="24419" checksum="F5D15F94332AA626" modified="2013-06-26" version="1">MAVESANGPGTFSATATSPAARSTAGSSFLPMTAASAVKPADMISDSRSAAMIVTATSVARRCKHTDELIQVKVADFHGVCSPTSSSCTTTGYLFPLIICILLTFIGSAWEVVVIYGVYPRQMFIYRNDSRADARRTDEVETCPLGAAIDLNLLQQRIGTGVVRDEVSRYGTNVYARLALIEWANREATVWREPLSSWMKVQQRLNRRRQRSLLLCFREASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q308</accession>
    <name>N1Q308_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_20460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q308"/>
    <dbReference type="eggNOG" id="ENOG502RGHA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1777380_0_0_1"/>
    <dbReference type="OMA" id="YEKLSWF"/>
    <dbReference type="OrthoDB" id="5372011at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="146" mass="15882" checksum="301FC3A9436E843F" modified="2013-06-26" version="1">MNASGSSAVTAKSTRTPKSPESFDSLRRRNTAAEVLQSYEKLSWFSIARCESIVQTRAHFQRIVAGFGDLTAEDIKWNEDFTPHPGSKPSKKGKERASLGNMSGQPDASGSGRKDKGKGRQKEGADSASNNESPGQQQLHNESNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q365</accession>
    <name>N1Q365_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q365"/>
    <dbReference type="STRING" id="675120.N1Q365"/>
    <dbReference type="eggNOG" id="ENOG502QTQR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_811399_0_0_1"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME50112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="342" mass="37541" checksum="FBD18122C9192D63" modified="2013-06-26" version="1">MGKADVEAAQAMLGIVHTPPGSAVGDGVVLVCIDCEAYELAQHKITEIGISVLDTRAVRDLSPTDSADKWFSKIASHHFRINEFADLVNKKYVKGNPEAFAFGTSTFIDKEDAKSVLRRVFEDPVTANSDDAVSRRNVVVVGHSLKNDVKYMHHLGFSLNDIPNIVRRLDTQSLVGSKKTDLSLSRLLRVLEIEVDPEHLHNAGNDAAFTLQAFVLTALKEHAAPGSVSSTIQRLRAEAAATRTARKDGTRASSAFTESATTDQDRHADAVRSTGDGLFAPGTHPTDQAHKPIHRQVRSMEDYETSINKMSRRQRKLMRRAERRAAKLADDQKTLGANTPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3E4</accession>
    <name>N1Q3E4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="3 15">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 15">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 15">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DOTSEDRAFT_68987</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="3 15"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3E4"/>
    <dbReference type="STRING" id="675120.N1Q3E4"/>
    <dbReference type="eggNOG" id="KOG1975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020346_3_1_1"/>
    <dbReference type="OMA" id="KPFLEVW"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 15 16" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="18">
        <location>
            <begin position="130"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="319"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="139"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR028762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EME50306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="515" mass="57668" checksum="4D38090F73C5E294" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3U2</accession>
    <name>N1Q3U2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF962 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_142755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3U2"/>
    <dbReference type="eggNOG" id="KOG3292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081702_1_1_1"/>
    <dbReference type="OMA" id="IQFIGHY"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22203" checksum="8E04A88351125531" modified="2013-06-26" version="1">MALNLERQLLFYGSYHHDPVNIGIHITFVPILLLTGFLFATNTPALAVPDWLSIPYIPYNLGTIACFLYSSLYILMEPVAGAMLAPLLLGGTAYANHLTSTYGMKANYIAIGIHIVSWLVQFVGHGVFEGRAPALLDNLVQAIFLAPFFVWLEVLFAFGYRPELKARLDTAIKAEVTKFKAEKQGKQANGGTSGKASCNGHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q452</accession>
    <name>N1Q452_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Versicolorin reductase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dothistromin biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_50174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q452"/>
    <dbReference type="STRING" id="675120.N1Q452"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="ELWYDVI"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME50033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="246" mass="25509" checksum="9B70160162D96698" modified="2013-06-26" version="1">MASQAFTDRVCLVTGAASGIGRATAIKMASLGSTLALQDINSSGLTETSNLCGGTHYTSTFDVSSSTACNDFIAALISKFARLDHIFNCAGVNPTAYALEDTSDGYWDKLINTNLRGTYNITRAAIPVLQEGASIVNVSSIMGISVAANYAIYCATKWGIVGFTKAMALELGPRGIRVNAVAPGYIDTPTNAGVVAGPEAVAAQTRQVALGRMGTAEEVADVVAFLFGREARYMSGSVVEVTGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4F9</accession>
    <name>N1Q4F9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_68305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4F9"/>
    <dbReference type="STRING" id="675120.N1Q4F9"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME49494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="442" mass="48771" checksum="D79340597CC86894" modified="2013-06-26" version="1">MEHLKIVIVGGGIGGLSAALALAAAGHEITLFESAASFENVGAGIRVSPNTSKLLLSWGVDLGSIKKEVSRGNRFVDWQGHVLLDVPLTGVQDLYGGPYYFIHRADLVASLVRAAKQRDNITIHMGCRVQSYDFDAPAVTLTGGETARADLVIAADGIKSSVRDVINGRPLPPQDTGDVAYRILVPAKPLLDDTQMAYLVKEPWAVHWMGAEAHAVGYPLRGGELYNIIIDVTHSSDLGEPLPEDEQIWKSARDNRELVARFAHWCPEVRKLCSMAGEYLKWKLADFDQLDTWVHRGGKVVLLGDACHPMMPYMAQGAAQSTEDAATLAAALKKYDSLHRALQAYEAQRKPRAAYIARNTRVLQDWLHLEDGPARDARDDMMRHDDENNPIFWGYNARKSWLFGHDASQIPQQREAIPSLPPEPPKAASVYASKRHSTTSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4Q6</accession>
    <name>N1Q4Q6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4Q6"/>
    <dbReference type="STRING" id="675120.N1Q4Q6"/>
    <dbReference type="eggNOG" id="ENOG502SIJT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017507_1_0_1"/>
    <dbReference type="OMA" id="FCRPMRR"/>
    <dbReference type="OrthoDB" id="3912356at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="511" mass="58983" checksum="8388CABB1E1E659D" modified="2013-06-26" version="1">MELTQAPNPNSWQAKLVVRLAKGIRSDKNFSEARVQEKRRKETAKLQKKSRRPATTAALEVNELGERQYSVFTDSATLASVRKKRDDGDMLHRLAHHDSFDSLLDKPHMLEQLRDPYFDSTMQRRVVQPRSELHEVRVANLPDELWKRIASFASPAEAANLAMSTKTLYRKLGFAPLDALNLPENKHYKNAFLYQFDNLFPGHLLCFQCSKYHKRLNSGQEQLKIEFVKNPVFDCPRVKSSVLPRMRITHGRELPYAFIQMATRHTRHHWSYGINHDTLSRRWKCKDSTWTHRTRFMVHDGRLLMRVVSQAYAPPARTLTETAERHILYDREEYTPFFSVCAHWKDGDLMKICKCMMSHVPAPPQSYRKQMDERGLHLSRSLANPDFIVRGCDECRPARRCSECPTEYLVEIRMIEDPKDVACPFKHNIVVTRWSDLGDGSSPFTSPEYVAINGIDVGYEETEKFDSFTSVGRRAVGGVFESNVSGSIPGQRLVSLNPKNKRLGEEGHGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4Y6</accession>
    <name>N1Q4Y6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_77016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4Y6"/>
    <dbReference type="STRING" id="675120.N1Q4Y6"/>
    <dbReference type="eggNOG" id="ENOG502SE9E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026660_0_0_1"/>
    <dbReference type="OMA" id="PKRHAAC"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110442" description="Zn(2)-C6 fungal-type domain-containing protein" evidence="6">
        <location>
            <begin position="32"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME49834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="520" mass="57852" checksum="CA9C7D64BB4FB538" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5A5</accession>
    <name>N1Q5A5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endoplasmic reticulum chaperone BIP</fullName>
            <ecNumber evidence="4">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endoplasmic reticulum chaperone BiP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Immunoglobulin heavy chain-binding protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_145099</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="4"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5A5"/>
    <dbReference type="STRING" id="675120.N1Q5A5"/>
    <dbReference type="eggNOG" id="KOG0100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_0_1_1"/>
    <dbReference type="OMA" id="VQRDIKH"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000009">
        <property type="entry name" value="DnaK-type molecular chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME50320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="683" mass="74477" checksum="7606B4CB8ED9E535" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2WI80</accession>
    <name>M2WI80_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Versicolorin reductase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dothistromin biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_75457</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WI80"/>
    <dbReference type="STRING" id="675120.M2WI80"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="NCTQEAW"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME38713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="256" mass="27112" checksum="109ADC7C473018AC" modified="2013-05-01" version="1">MSERRGKLHTKVAIVTGGSMGLGEGIVRKFIEEDSRVVIFDINADLGRKLVASSPGNSASFFEGDVTDEQSWEAVLEHTLKTFGQLDVVVNNAGVVHRSAPSNEVPLSEYDRIMKINVSPLYHSAKIIFPHFKAQGHGVFVNVSSISAPRPRPNLVWYAGSKGAVSAITKGLAAEGAPFGVRCNAICPAVAETGMVSSVLGGTDTPEGRTRLLAQIPMGRIGEPRDIGNAAAFLASEESSFITGIELPVDGGRSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2WIU6</accession>
    <name>M2WIU6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GPI2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_180854</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WIU6"/>
    <dbReference type="STRING" id="675120.M2WIU6"/>
    <dbReference type="eggNOG" id="KOG3059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024002_1_0_1"/>
    <dbReference type="OMA" id="ILWDSWV"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="248"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME38888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="52974" checksum="BFE70BFFA95873EC" modified="2013-05-01" version="1">MPPYTSNSTAPSTIQSSRASSIQSRRLDRRESAQHLRPEDAYTSPPRKGSLGRSGTVTASNFTQYPGTSYPPSTSSRRKRRGRSSSRKRNNAGNIPKIGNGQWKKLLWVKQNYPDNYTDEETFLDHLQRNPSLRPYEFWPLVADSTIIVQHVCSVIIFVSCFSAIHVGRLSPQTVVGWATGCTVLGWVFRDSWQSQTTSEEGSEEGETGDRNAEGEESERYGEEMVGLGYKDMASLVSTRSHSRDVSASSFGLEQGQGMSGASSPLNATGNGETISTSSAFTTPDGGSPSPFSPRMQERLTTAKSAILIYCSLLGLSPILKSLTLSTSSDSIWALSSWLMGINVFTFDYGAGPAAKFPASLSTNAALMASTVLASRLPTTTHVFSLTLFSIEVFGLFPVFRRHLRHHSWTGHLCLTVLLVVLASGGLSVTISGGAWGMAIVGIVLGGLVCCLSMGVTSWWLIGLQRYKNEIHGPWDPARPVIGRRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJQ6</accession>
    <name>M2WJQ6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_66253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJQ6"/>
    <dbReference type="eggNOG" id="ENOG502S7FM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042952_1_0_1"/>
    <dbReference type="OMA" id="EMWSRCK"/>
    <dbReference type="OrthoDB" id="5327145at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="390" mass="42585" checksum="D791B72F5639100F" modified="2013-05-01" version="1">MFATRSHDENAIHQRQQAAAAKPLNQGVKGLAPKTPAGKPPKTPFGKTRNDENVQRTVGKGGGKNGQLERNVFITPANPQTRAPLGAKTTNGRALKSPGPFLVPDKPNDGDRPSSTKQASLRRSKIRVHESVENDILSRDPEDREIEYMPPRGEPLPEDYTDDFPYELSYAAVQGKNLTRGWWSEYDPNRKEDNDDDSELSDFDQKFKAAEERERKELAAKKKPLASKSTNATVVKAAPGTMKAKSAATALGSRSTKMGPPTFSAPTAATKARQPFGAVNKPLTETKRAPIFDRTNPRFTAAKAASNSTIGYSKGRVVSANRRPLTDIHAAPKVEEPKEDKTSLAELLQLGSVHINDGDDDLLGRSNNGSDLLEDDDEPEVFQLDVPQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2WK79</accession>
    <name>M2WK79_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fms interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_138758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WK79"/>
    <dbReference type="STRING" id="675120.M2WK79"/>
    <dbReference type="eggNOG" id="KOG2216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082754_0_0_1"/>
    <dbReference type="OMA" id="HKYMKLP"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24519" checksum="E6BF4E5BB6D2BF34" modified="2013-05-01" version="1">MAAEHLITDPTLLSVLRAAEEARRQCLELTDLIAQNHTSEDPSDKQYDAQRKVNARLALLRGLNRNAVKSVRATKQETTEARQEIDSLHLELQNLRYEQGHLRGEIRGCEGFDHKYTRLPMISTDEFLALHREYADSNDHDLTLARIAYEHVARQELEKQRQELVKRKDALVKETNLKKEELVKLDNEVERWLGGQDNVRKIFEKRAKQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2WLA7</accession>
    <name>M2WLA7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferric oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_173245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WLA7"/>
    <dbReference type="eggNOG" id="ENOG502QVV4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005562_3_0_1"/>
    <dbReference type="OMA" id="ITYRIWE"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47627" checksum="0DDAD8E714CC50F8" modified="2013-05-01" version="1">MYRRLHITVLLGNLIALVYCTVQVAKHGYSRYTCTDASNGVVLNLFVGTLMRHEHAINFFFRMCTMLPHSTPLAIRRYAAKVYSHGGIHSACGISSLFWYIFYVVLLLKQFGGYGEDQTPLLHALQATTGVMMALFVILIVMAYPTIRSKYHDWWELSHRFAGWTAILVVWAQTVIAAWPMADILDTNVGLILIQTPSFWFLLAITCMIIYPWLRLRRRAVTIEPLSDRATRLHFTDRKVISCVGTRLSSSPLTENHGFATIPNPDGHNGYSVIVSNAGDWTNKIIKNPPTHLWMRGAHTMGVSRIGLLFQPVIMAATGSGIGPTLSFLQAHPSWPCRVVWSATYPEETFGKEILKAVLRADSEAVIVCRKKTGRYRMHELVYAAYRSFGAEAVVLISNPVETRRTVFELEARGVPAYGAIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2WMU1</accession>
    <name>M2WMU1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucose 6-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_54187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WMU1"/>
    <dbReference type="STRING" id="675120.M2WMU1"/>
    <dbReference type="eggNOG" id="KOG2666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_621158_0_0_1"/>
    <dbReference type="OMA" id="IMEAHRP"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase N-terminal" evidence="3">
        <location>
            <begin position="38"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase dimerisation" evidence="2">
        <location>
            <begin position="204"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME43333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="47103" checksum="8C48C1D7238B52C8" modified="2013-05-01" version="1">MSEMVLSHRPATPTQPALHAVFPDILNPDTASNVPIRSVCCIGAGYVGGPTAAVIALYNPHVRVTVVDRDELRINAWKGRHLPIHEPGLVDVVRLARDGSTSSRHVSGARQPNLFFPTSCTQIIAEADMVLISVNTNTKKRGVGAGRATDMTALEGAARDVAIHAKAGTIIAEKSTVPVKTVQLIKDIMEAHRPGLVFPQHQYISAICEKTGADVGEIAKSVGLDPRIGPQFLKAGLAFGGSCFRKDIASLTYLADHWDCLKLRFNGSSEGDIRRELSILEGEYPVAKPNGPIEVVLDSYAACADSSAVLVLTDWDMFKDTMISSSKPIVHDTCGAPPGAIPLSDHAVKPAMPAKTSSLPATMAEQLIPELACPSECGECANALATGQFADKNITTPLSWSAISQSVREPRWVFDGRGLLDFHPMTSLGSRLETLGQASIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2XJA8</accession>
    <name>M2XJA8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_75271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XJA8"/>
    <dbReference type="HOGENOM" id="CLU_2527428_0_0_1"/>
    <dbReference type="OMA" id="FEGAAHQ"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004028726" evidence="2">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="84" mass="7899" checksum="13C3E99A5420EEC2" modified="2013-05-01" version="1">MQFTTMITLAFGLVASTSAASVAAPSYSNTTAPSYPANGTTTSSPSPSGTGAGGSTGAPFEGSASRLSTGALGLVVVGGLALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKI5</accession>
    <name>M2XKI5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_35357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKI5"/>
    <dbReference type="STRING" id="675120.M2XKI5"/>
    <dbReference type="eggNOG" id="ENOG502RN34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068279_3_0_1"/>
    <dbReference type="OrthoDB" id="3650764at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="248" mass="27955" checksum="EB9083DDDA94DF91" modified="2013-05-01" version="1">MSSPAGSSAKHRKLNFSDNVVVLAGAQKKSYTVHKDALVKHSKFFRAALWNGLKETRRYVAGAEDETKENADSGQVVRLPGIEPEMLEAYLQWSYSGQIVLTETAEDEKSNRGIDFQLDLARFYVVADVLDDALLRNSILDTMMASMKQAKRGPGPGIIREAYEHTSAASKLRQFVLEWHAFRIGAGARMGYVTWLERNIDHLPRNFVHEVLLRVARGREQRGPEVCPDAAERCRYHEHNDEVPACTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y0Z2</accession>
    <name>M2Y0Z2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_39165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP40 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y0Z2"/>
    <dbReference type="STRING" id="675120.M2Y0Z2"/>
    <dbReference type="eggNOG" id="KOG1004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069847_0_0_1"/>
    <dbReference type="OMA" id="SYMAFPN"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000127">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000073">
        <property type="entry name" value="Putative Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="11">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="153"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME38974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="243" mass="26288" checksum="A71F9B8116EAC72B" modified="2013-05-01" version="1">MATILLPGEQIPTDQLPKSKKGTLTLGPGLRHIPPQTILTTTSGTLQIDPKKSALWLEHPNGRYVPSSGDLIIAQIHHTGSDVYFCSLTPHTPHALLGQLSFEGANKKSRPQLKAGDLVYARVTSTSRWEDTEIECVSSATGKADGMGPLSGGMCFWVSCGFARRLMMGTGKEGRSKGGVVVLEEVGEKVRFEVAVGRNGRVWVDSGSVRETVMIGRLLRQADEEGLDVEAQKKLVKRALKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y111</accession>
    <name>M2Y111_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_181064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y111"/>
    <dbReference type="eggNOG" id="ENOG502THAS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044618_0_0_1"/>
    <dbReference type="OMA" id="AQHEMSK"/>
    <dbReference type="OrthoDB" id="5379086at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="454" mass="49544" checksum="78D202A6A9F4429E" modified="2013-05-01" version="1">MTKIGPRARKLAAAVGPSTAEDYTIINDLLETVERNPGSVDARWVLAEQYDAFGWVDAAGDIVEEILTLRPDDLVAKAWLEKHDRPLATAKSAAYTMTQPVEDNLDLTAPELLPGDLRELEDDYKSLLLDAQRLLLEVQAFQDMCGPEVNIVGQAADLKAVAEGRMTSAVRARPSPAVRTIALSIKEDAGPRRVDLACNDLEANARWVRSQAPGTNADRIRDAVRKRAEALKAALPGELCHAIDDAWMHTEHEILGRTYQNGRQTMLGDLITAIPRASFYVTEDGYAWDMAELASAIKANGGVMRNPLSKQMFSADDVRAFIRHPLGKGLAALRLKQKELTSGVRRTTVVKVAEMAAVLLDDQTADAAASREAVEDFLVYTATLPQTEQDALKDLRVPAKDSHTGQAFDVTIGDAVEDAKANRQCFHKTGDLLKQAAKWLANQKAGAQMPGAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y1C6</accession>
    <name>M2Y1C6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eisosome protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y1C6"/>
    <dbReference type="STRING" id="675120.M2Y1C6"/>
    <dbReference type="eggNOG" id="ENOG502S8WV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009741_0_0_1"/>
    <dbReference type="OMA" id="EHTFSGF"/>
    <dbReference type="OrthoDB" id="4070583at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024527">
        <property type="entry name" value="Eisosome1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298:SF1">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12757">
        <property type="entry name" value="Eisosome1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="902"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="678"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1259" mass="133292" checksum="FB9C1C9CFEB12735" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y5F9</accession>
    <name>M2Y5F9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_93721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y5F9"/>
    <dbReference type="STRING" id="675120.M2Y5F9"/>
    <dbReference type="eggNOG" id="KOG0814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_6_2_1"/>
    <dbReference type="OMA" id="HTHEPKH"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16713" checksum="B2B0C7B5B55C57C6" modified="2013-05-01" version="1" fragment="single">PLVHTLYEELTCTWQYIVADPVTRHAIIIDPHLDNSPASTDISTIAADRVLSVVHQNRYFVDRILHTHEQQQNPSSAWYLRTQILQSEGHAPQVNIGRKMAAVQRVFKRKYSMNDGSQWKTAFEGSFSDGEVFRIGTISCHVLHLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2YHP6</accession>
    <name>M2YHP6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_29780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446551">
        <property type="protein sequence ID" value="EME38025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YHP6"/>
    <dbReference type="HOGENOM" id="CLU_1677844_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="157" mass="17513" checksum="B45F9B296545DB54" modified="2013-05-01" version="1">MAALASSGLENHPYPKQQFLRIEPDSKESCCPIRRIRSWILDDIVRAGPVQCLAALTESDCDGRYASSTSTQEPIYDGLSFMTQIVAEGMKPGVPCPCRRLILLVQAAVTWRDYNFMTLTARKAIAIAREQGTDWDYLAILCPELGTKVEQSIRDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJM5</accession>
    <name>M2YJM5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_91596</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJM5"/>
    <dbReference type="STRING" id="675120.M2YJM5"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OMA" id="VIGPCGR"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF5">
        <property type="entry name" value="GENERAL AMIDASE-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="87"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="237"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME39131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="554" mass="60602" checksum="6BD178EC62DE8827" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2YK89</accession>
    <name>M2YK89_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_179769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YK89"/>
    <dbReference type="STRING" id="675120.M2YK89"/>
    <dbReference type="MEROPS" id="S10.016"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_3_1"/>
    <dbReference type="OMA" id="PCSVNAD"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF189">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004029930" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME39295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="69430" checksum="F9D362AD1CF94761" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLA7</accession>
    <name>M2YLA7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="5">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_131971</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLA7"/>
    <dbReference type="STRING" id="675120.M2YLA7"/>
    <dbReference type="eggNOG" id="KOG2795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037229_0_0_1"/>
    <dbReference type="OMA" id="IYYLDPV"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1360.10:FF:000018">
        <property type="entry name" value="Type II DNA topoisomerase VI subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013048">
        <property type="entry name" value="Meiotic_Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01551">
        <property type="entry name" value="SPO11HOMOLOG"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="13">
        <location>
            <begin position="48"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="14">
        <location>
            <begin position="159"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME42796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="342" mass="38107" checksum="08DB203EB7A2D8A6" modified="2013-05-01" version="1">MADALLNDKNELSITLKVRNSRAKGLRASRDGRAKQICFPGKTEDEAWRFAVVLRILELMHEALRNDVVMSKRDIYYRDPALFGNQTYVDRYVDDIALTFGLSRASLNVCAVAKGLVAGAFTIYRKDGSSTIANNDREGLLVPSLRDIQAIDVKMVNWILVIEKEATFRSITAGPFWDTIATQGIVLTGKGYPDLSTRALLHFLSTASPENGFASPPVYGLADFDPDGLSILSTYRRGSKSLAHESEAHCIPQLQWLGLRSENLYMDQANTHASQGLLKLTTRDRKKAVNMLVRNDDWEVPEEWKAELRTMLMLNTKAELQLLDATRHGTADLLTAKLSGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2YM47</accession>
    <name>M2YM47_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_153397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YM47"/>
    <dbReference type="SMR" id="M2YM47"/>
    <dbReference type="STRING" id="675120.M2YM47"/>
    <dbReference type="eggNOG" id="KOG1416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010916_2_0_1"/>
    <dbReference type="OMA" id="EGYIFHA"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME43086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="580" mass="64732" checksum="D83B23FAA5F58902" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBI9</accession>
    <name>N1PBI9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_57494</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBI9"/>
    <dbReference type="STRING" id="675120.N1PBI9"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1384132_0_0_1"/>
    <dbReference type="OMA" id="ASHNIKG"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="53"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME38387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="197" mass="21443" checksum="9FD66FF4BA566E96" modified="2013-06-26" version="1">MDRLATLLSHLLATPYRPRDLAKFDTEPTFDENGLLTFCPDDPEDPRTWSTPRRWYISLTTILLVVNATFASSSPSACLPSISADLHVSPEAAALVITVFLLANAISPFVWAPLSEHCGRRWIFYGTFIGYFASDFLCAWAPNFAALLVGRFLTGIFASSTQSNAPGLLADIWGPLERGNANAVFSVMVFVGPALGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBS5</accession>
    <name>N1PBS5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_98316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBS5"/>
    <dbReference type="STRING" id="675120.N1PBS5"/>
    <dbReference type="eggNOG" id="ENOG502SDK3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093235_1_0_1"/>
    <dbReference type="OMA" id="QFYNEGY"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME38592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="143" mass="15651" checksum="347F365EF4B8C069" modified="2013-06-26" version="1" fragment="single">DLFGDVLNLEDQYYQEGYDLGVADGSRSGRIEGRTFGLEKGFEKFVEMGRLHGKALVWEARLPAAQSDDTRSSDATSMGGLPPLQAPSGNARLQKHVERLAALSDPNDLSTENSEDAVSEFDDRLKDAKTKTTLISRMAGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBW8</accession>
    <name>N1PBW8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_74669</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBW8"/>
    <dbReference type="STRING" id="675120.N1PBW8"/>
    <dbReference type="eggNOG" id="ENOG502QVQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027506_1_1_1"/>
    <dbReference type="OMA" id="VRLGIWP"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108995" description="chitinase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="15">
        <location>
            <begin position="42"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME39843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="381" mass="42042" checksum="78C428212283CFBE" modified="2013-06-26" version="1">MSRFLILPLAISALRVAAQTSTDCNPLNSTCADDPALGTTFYDVYNKSVSQFDINYWNVTAGAQLISFDDQNGAALAIDGEGDSVTVKSNFYIFWGTVEIMMKAASGTGIISTVILLSDDLDEIDWEIMGGNLSTVENNYYGWGNTTQINSEYPALDGAQDDYHNYTIVWSQEKLQWMLNGNVVREQSYLDPGLYPQTPCRIQFGLWCGGCSKSEGTVQWAGGKADFKDAPFVMNVKSIKVTDGTTNSSSYSYGDHSGLWSSIQIKDGESEAYKHINKLTTVQSAEKDWQGLSIGAKIGIAVGVIGGVLIAVLAWMFLCISQRKKGRVEAAEHEKLWEQQNAELMEYKSMMAQGNFAVSRQSIMMEAKQDRPRSFLHGGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCD1</accession>
    <name>N1PCD1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_99043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCD1"/>
    <dbReference type="STRING" id="675120.N1PCD1"/>
    <dbReference type="eggNOG" id="ENOG502SQ3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011409_7_1_1"/>
    <dbReference type="OMA" id="ITRRIMH"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME39897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="560" mass="63963" checksum="7F742529403E5EB4" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD65</accession>
    <name>N1PD65_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_75804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD65"/>
    <dbReference type="HOGENOM" id="CLU_1835123_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="140" mass="15521" checksum="ACE4E52BC919A28D" modified="2013-06-26" version="1">MLHVNGYGHGLPTATSLLAAALDTRERRMLPACFSSIGPGRTNVMWRHSIGPDRQTYGQAIGRILPLASKSCCGLHGLYHFLFRSSLQDASRTIILKHARTLHLCLSPVTSEIVPFHLALFTSTPCYERMSYPTGHYVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDX8</accession>
    <name>N1PDX8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_112179</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDX8"/>
    <dbReference type="STRING" id="675120.N1PDX8"/>
    <dbReference type="eggNOG" id="KOG2632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084816_0_0_1"/>
    <dbReference type="OMA" id="NTYPIVH"/>
    <dbReference type="OrthoDB" id="10257275at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="17"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME40304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="232" mass="25792" checksum="1D5451825F65721B" modified="2013-06-26" version="1" fragment="single">SITEWGALIPSEINFRTLYRLNTYPLIHRDIFHYLLNILALVPLLERFESEHGTITTFILFTGPFGLLPGGLYTILERFIFHFNGAAVGSSVWVFLLLCNEAMKTYRANPYFQLEDIKIPTWTTPLFLILVINFLIPHTSLLGHLSGAATGYLWGLGYIRFLAPHDKILTWIEGKLNLLGRLPHYVSVDQKTYGRYGVLPSTRPGPAPGRGTLGAANGVAVGPVGSTQRLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFG7</accession>
    <name>N1PFG7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_137759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFG7"/>
    <dbReference type="STRING" id="675120.N1PFG7"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_0_1"/>
    <dbReference type="OMA" id="FEWADWE"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF103">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSIDASE MNL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME40046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="547" mass="62642" checksum="7E7FBFE44B2DEB9E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG66</accession>
    <name>N1PG66_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_73701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG66"/>
    <dbReference type="STRING" id="675120.N1PG66"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013661_1_1_1"/>
    <dbReference type="OMA" id="YAFSGYE"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME41367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="73659" checksum="B646CA3C8FC7E979" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGT5</accession>
    <name>N1PGT5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_90398</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGT5"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OMA" id="WGILNAY"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="50"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME41587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="439" mass="47004" checksum="02E53DC8114C838E" modified="2013-06-26" version="1">MDSDQELERSDGDASDKASETSCSVFYDEKTTEQRSGPEISSSPPDGGIQAWLQVLSGFLLYFNSWGLVTAFGVFQIFYKSTFIPSSSNSAISWIGTMQGFLLALGSVFAGCVLDRGHPRRLIICGGFFVIFGLMMISLCRTYWQLMLAQGLCIGLGAGQLFIVAVAVLPGWFAKRRAIATGLAATGSSLGGVVYPIIFHKLEPRIGFAWTLRVIGFVALATCLISLTCSRQRTLPPPRPKLVDFTGFREPLFALFAAVSFVGALSLYVPFFYIVEFAKHKGGVNDALAFYMLPILSAGSILGRTLPALAADRFGCLRVLTFTTAASAILAFCWAAVYGEAATIIWSVLYGAFSGAFVSLQTPTVAAVTPDMRFVGGRMGMNNFCFALGILVGNPIAGAIGGAFEHWLGVQVFCGVSLVVSTVLLAVTWFVKEGAGTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGW3</accession>
    <name>N1PGW3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_81704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGW3"/>
    <dbReference type="eggNOG" id="ENOG502T1ZY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142963_0_0_1"/>
    <dbReference type="OMA" id="CFKHLTR"/>
    <dbReference type="OrthoDB" id="10593803at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="155" mass="17161" checksum="05EF686FB00E96D6" modified="2013-06-26" version="1">MGLLKRKAKTPSPATGADGETAEAANSTIPHAPSAAHLALITERETTSDAYKKAQKAEKQYRTHRQAARARTEYAAAKTHVKTAHKELISGMKASVRVVGLFHYVLKEKMSATPEDKQKRKLERTASKRQKLEEKMKKIEHEDKGEDAEPEAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHM5</accession>
    <name>N1PHM5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endo-1,5-alpha-L-arabinanase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_65631</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHM5"/>
    <dbReference type="STRING" id="675120.N1PHM5"/>
    <dbReference type="eggNOG" id="ENOG502SM7B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010779_2_0_1"/>
    <dbReference type="OMA" id="MWSEDDT"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08983">
        <property type="entry name" value="GH43_Bt3655-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18828">
        <property type="entry name" value="GH43_BT3675-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="7">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME41050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="626" mass="69451" checksum="121B5098295A3B7E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHV8</accession>
    <name>N1PHV8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fdo1</name>
        <name evidence="7" type="ORF">DOTSEDRAFT_36107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHV8"/>
    <dbReference type="STRING" id="675120.N1PHV8"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_1"/>
    <dbReference type="OMA" id="INKRRMP"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF316">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME42183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="401" mass="44902" checksum="CF10DF1380D6F428" modified="2013-06-26" version="1">MTFRNVAIIGAGLSGLTLALFLERYGIQSTVYELRRPDVRSDGAVMLSPNALRTLDAIGIYSKIKGKGYHFRDLTFRNNQHKLLDAYEMGNADKFGYDALRVYRQVLLDETKAMVQAAGIEIVYEAKFSHVILEHDNGVTFAFTNGEQKTADLLIGADGIHSTVRKYMVPDVKPTFSKFMAVTCAIPTSAIKWPFEPYSMPVGIHGTTGAFVMAPQNPEGSEVLAGTQFRTRERSQAEWDALCTDKKGLLEILRAHYDLYNETVQSAMDAVPLQTLSIWPFYTVPKLTRWSSGKGRIVTLGDAAHAIPPAAGQGVNQAYEDVHAFSLVIAATNDKKSSWYAGLRWWQEYRQARVERVTDLTNEMNKRRLPGWNGEEGSIDSSWLFSVDIEGDVKNWIESRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PII8</accession>
    <name>N1PII8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_64688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PII8"/>
    <dbReference type="STRING" id="675120.N1PII8"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="OMA" id="ERSEICY"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="283" mass="32059" checksum="AB342D8B8F083084" modified="2013-06-26" version="1">MLLINASSLQFEEFEGHSTPAYAVLSHRWGARGDEVTYDDYVRGLKKDSPGFKKITQFCKHASATGLGWAWVDTCCIDKKSSAELSESINSMFAWYQKAHVCFAYLQDVDNAETWRESAWWQRGWTLQELIAPESVIFCDREWREIGSKHGMADQIAALSRIPGAVLKVRGMYRHATIAQKLSWAAGRLTTRREDVAYSLLGLFHINMPLLYGEGDKAFQRLQIEILQKYSDESLFAWSCNSKGPHLVLAPTPASFRTCGNMAPVSQHLKEDLPKHHRAVHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIN7</accession>
    <name>N1PIN7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME41994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIN7"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_1_0_1"/>
    <dbReference type="OMA" id="MRHGQGY"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27635" checksum="5AE1F8E768339584" modified="2013-06-26" version="1">MRHGQGYHSHEVTKDGHLLRDPSLTEKGKQQCRDRCNDFDRHDKVDLLLASPLRRAIQTCQLSFAPCVERGLVIIALPTAEEVSEAPSDTGSPVEDLIEEFGSEKVDFDHLKHGWYKHEGEFATDAKACNARALKLRKWIKARPEREVALVSHGFFNHFTTGEVDDKGEQTTPWWNEAELRTYQFRDGDEEEAMIDETDESLEKRGMRREGAEVGGAVKFNQPSRRGTLPDLSYQNQEHEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJS7</accession>
    <name>N1PJS7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-1-phosphate guanyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Translation initiation factor eIF2B subunit epsilon</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_73260</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJS7"/>
    <dbReference type="STRING" id="675120.N1PJS7"/>
    <dbReference type="eggNOG" id="KOG1461">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012507_1_0_1"/>
    <dbReference type="OMA" id="LAQSCKI"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05787">
        <property type="entry name" value="LbH_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="12">
        <location>
            <begin position="524"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME42374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="707" mass="78320" checksum="4E5FE3F1FDB92FCB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK44</accession>
    <name>N1PK44_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="6">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_73528</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="6"/>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK44"/>
    <dbReference type="STRING" id="675120.N1PK44"/>
    <dbReference type="eggNOG" id="KOG2682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_0_0_1"/>
    <dbReference type="OMA" id="ATHSCID"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="12">
        <location>
            <begin position="16"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="287"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 10">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="44"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="242"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME42767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="388" mass="42964" checksum="9A4852E7A2F1953A" modified="2013-06-26" version="1">MGNEESSPIDEATPPQTLTGRTIEAVAEYIRSGKANKIVVMTGAGISTSAGIPDFRSPETGLYANLARLNLPYAEAVFDISYFKEKPEPFYTLAHELYPGKYRPTITHSFIRLLQDKGLLLKLFTQNIDCLEREAGVHDDKIIEAHGSFARQSCIECKQPYPDDEIREHINNKTIPQCHNCEGLVKPEIVFFGEQLPAAFFENRDKPAEANLAIVIGSSLTVQPFASLPQMARDGTPRLLLNRERVGGIGSRSDDVCVLGDCDDGVRRLAKALGWLEELEALWATTAPKTAQDAKTASKKSRDEAFQEEMDKLTKEVDETLNLSKYHQERVRNERLPGESKEETNTTKPDPTEGNELNHVFVGGPRVDSFTPAAGSRADGEKSDNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK50</accession>
    <name>N1PK50_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK50"/>
    <dbReference type="HOGENOM" id="CLU_1180194_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="235" mass="25783" checksum="7AC5A918FD68EC9D" modified="2013-06-26" version="1">MLSAIAENSQAGRLLERRRPRNLGRDIRWNRLPENTNEHVFVMLEEAGGVFGFVDRILEGYLESSCSEPRDKIFALVGDPVMRALDPAMRLVPDYALLLEELALVFIAYCDGIHASWSQILPGLAGSHTPSKDLPEVLLSLHRALGTERDPRKFLEALDGCVVRTEDSTESSTMVLLCGARIGCSGPLMGALLDLPTSRYSTRSRASISGDHGVASTVDGTMRRMSCLCPDCPYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKH5</accession>
    <name>N1PKH5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKH5"/>
    <dbReference type="HOGENOM" id="CLU_959857_0_0_1"/>
    <dbReference type="OMA" id="ESENNDC"/>
    <dbReference type="OrthoDB" id="3905718at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="290" mass="32305" checksum="A092E3100F40FF01" modified="2013-06-26" version="1">MAISTLNADDTDEEWILLFPKPAPAVETRPSNSNAWIDWQLRTRFGTFPSILGPGPLLANSSELPVSNDDDKPIHPQTHSPLCRLPTLFRLTIYDHILRIPSTTPDGSVKLTHNPSHHRHPPSVPALLQTCRLILHEAEGISFTLNRLCTDHILTFIHSVGERRRLAVTKFTLKANSAAAAHIGLQALEGFGNLESLYLERMASVKYQDVRGWAVMTPQIREEIRGMGRLRVVRVVRVLMPEAADLTEAERGRARRLREIDVGIKGAVGRVGEVGQTVEKVVGCAVHERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKZ6</accession>
    <name>N1PKZ6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_80002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKZ6"/>
    <dbReference type="STRING" id="675120.N1PKZ6"/>
    <dbReference type="eggNOG" id="ENOG502SEU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534206_0_0_1"/>
    <dbReference type="OMA" id="YYGPRGQ"/>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="353"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME44157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="510" mass="57543" checksum="A09CF04326299CDF" modified="2013-06-26" version="1">MRRTNTRLLRQVNGMSHASNENHELEPQYARPKPTVQHIEKLDKVYPSPATTASGNSSQVRPIEVASDDEPISEDDSPNLTTQWTTLLQYNKPVAASVEVMEDEERSTEKQEEVQGANQDKKPSSSSDEENEPDWLASSQPTSKKRKVLPASNIHAAATSTYGARPVKAYGSANQRALRRHKSDEARKKLKEKERSGFRTAKGIGLDVEKSPVAGFKRPRANIHDLVAKSPEKSPTVDAARQDSDDLDSLSDLDEKAMSTIEDGKQFLPSPKPFVSTHRCEHCGEEVAKLLYEEFIDDYNSGKELNIKWQRRFCNFHNRRKAEALWKERKYPTIDWSGLERRMRKHDNFLRQILKDERGSVHRKQLQKQLAPGRRSKNIGQMMNNQNVKAGTLVGYYGPRGQKAMVDHIIDNLSKDIREQAVHDDIVMASGAQGGVSGFVQSVLVPHLAEMLIKEDGYLTVEWEAEVRDIIAESGELGELMNPETEDEIKEVDDDDEDDDDDDDNDDGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLP0</accession>
    <name>N1PLP0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Frequency clock protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_73342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLP0"/>
    <dbReference type="STRING" id="675120.N1PLP0"/>
    <dbReference type="eggNOG" id="ENOG502RXI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007103_1_0_1"/>
    <dbReference type="OMA" id="PDHKKKE"/>
    <dbReference type="OrthoDB" id="2536795at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018554">
        <property type="entry name" value="FRQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09421">
        <property type="entry name" value="FRQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="902"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="937"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="975"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="984" mass="107470" checksum="6688939EAE101D5A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLR0</accession>
    <name>N1PLR0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLR0"/>
    <dbReference type="HOGENOM" id="CLU_2003867_0_0_1"/>
    <dbReference type="OrthoDB" id="2245455at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="124" mass="13733" checksum="632A95276422CFDF" modified="2013-06-26" version="1">MPSLADQQQQFKKEGLSNSDTTARNTTDSTASKNQQPAMGPTTSLGLAGNPFHYAIQQPKEHLFYESFLNSISNDIVRYLAMKNSDARKERTAAPSTPPTPKRRAGARPDGIDRKRSKRNSSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLW4</accession>
    <name>N1PLW4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_24515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLW4"/>
    <dbReference type="HOGENOM" id="CLU_1825243_0_0_1"/>
    <dbReference type="OrthoDB" id="10579805at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="141" mass="15966" checksum="7F9FEA5CC426028E" modified="2013-06-26" version="1">MSTKQSPLLAIPCEVRLQIYADVIASVTALDIKPPFKPTKTNKWWLRSFGDYSAPSLLLANRLMRAEALQLYHKFLLDHLVCFQDTIDKIDSAVNKFSLPPKENTFVRCERDAVEKDIRLVEGELDGQRAAQAEAAERSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PME6</accession>
    <name>N1PME6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_89947</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PME6"/>
    <dbReference type="STRING" id="675120.N1PME6"/>
    <dbReference type="eggNOG" id="KOG1484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013389_0_0_1"/>
    <dbReference type="OMA" id="VHYSGWP"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="652"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="448"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="574"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME42591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="820" mass="87593" checksum="9AC9BD27305A3B00" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMU7</accession>
    <name>N1PMU7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMU7"/>
    <dbReference type="HOGENOM" id="CLU_1927548_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="131" mass="14416" checksum="87D5F23E79DC483E" modified="2013-06-26" version="1">MSAWATAHDVDVLSRLLRIDYTRTLANRPAAVFPCHPFGKELSSVTSNLADIAASHLTRQEWDATNHAQGHALWYHGDHFLNELLYLMIGHEALSNGFVAAVALGGDLERGIRDCASILRNLAVSSDAYWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMX8</accession>
    <name>N1PMX8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_171584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMX8"/>
    <dbReference type="STRING" id="675120.N1PMX8"/>
    <dbReference type="eggNOG" id="KOG0141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_1"/>
    <dbReference type="OMA" id="GFPHDFH"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="50"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="167"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="279"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME43740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="48023" checksum="3FF344A545B6707A" modified="2013-06-26" version="1">MMALLPPLTRCALRSAARARPFHKPHRPVSLRSVHGQATEFLQMNDPDLTESQRTVREAIAKICQKFPDEYWKALDDSGKFSLDLHSALAKDGWLGICMPAQYGGAELGISEATIMMQTLSESGGGLTAASSVHMNIFGLEPVVKFGTEEQKERWLVPLIAGRERACFGVTEPDSGLDTLKLKATATRDSSGDFYTLRGSKIWTSTAQTAEKILILVRTTPLAEVEKPTQGLSLFYTDLDRSVVEVTEIKKLGRAAVDSNMLMFDGWKVPKADLIGEEGAGFKMIMHGMNAERLLLGGEALGLGFAGLRRASNYARERHVFGRPIGKNQGIQHPLADSWMKLEAARLLLYQGTKLYDQGYATGEYANAAKYLCADTAFEACERAVMVHGGMGYAKEYHVERYFREAMLPRLAPVSREMICNYIAERVLALPRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNP5</accession>
    <name>N1PNP5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_52420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNP5"/>
    <dbReference type="HOGENOM" id="CLU_1098485_0_0_1"/>
    <dbReference type="OMA" id="DYPFGRL"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28441" checksum="5128550D7F3A7980" modified="2013-06-26" version="1">MPPITLRSTANAQSPLLKLPQELVDLIFSFLYSETNLDIGPTRDAELRIFSNHLILRRTWPVPPPSWKGCSKVFRTCRAFYANGLNILYPQMTFSIRINGDDEDPGQRRSRLHSDYPFGRLDDCMPLRYLGAAQISLSAGSVQDLERLEERLGAFEEAVRGSERLRVGAVRVSLGRLVVTRAVFERVKRITDVVLKWCGNAKGDMKREGLMVKIFTNPGNDVPDHFLKDLASLVRSVDSDASVVSYSKGMVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNS0</accession>
    <name>N1PNS0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_71738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNS0"/>
    <dbReference type="STRING" id="675120.N1PNS0"/>
    <dbReference type="eggNOG" id="ENOG502SRDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263425_0_0_1"/>
    <dbReference type="OMA" id="RYEYDPI"/>
    <dbReference type="OrthoDB" id="3946750at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1235"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1199"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="698"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1202"/>
            <end position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME44035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1277" mass="145710" checksum="1824E85A9CFF992A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNT3</accession>
    <name>N1PNT3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_172863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNT3"/>
    <dbReference type="STRING" id="675120.N1PNT3"/>
    <dbReference type="eggNOG" id="KOG3082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_0_1_1"/>
    <dbReference type="OMA" id="KEWWNGV"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="378" mass="41606" checksum="5BFE11CD80537F24" modified="2013-06-26" version="1">MFRQHFLGRGRPATPSAWVKSYTSSQIRWSTGAEQRHRPLRVLFCGADQFSAASLWEVYSLQQKDRSKIASIDVVCRPDKKVGRGLKQTLEVPIKPFAINLGLNIHQIDTFKGWSPPQPVDLVIAVSFGLLVPSRILTGATYGGLNVHPSLLPDLRGAAPIQQALLQNRSHTGVSLQTMHPTKFDHGVIVDQTPAPGVLISENANADQLLQELTPLGAKMLRKAIEEGSFVSPQPLAQTSNLSGEHTLASKITPEDRHINWETWSSDRIIRYDRVIGRLWDTTTYQRCYLPHKNPSIKRVTFDGPWRRASRIEGPELAPGEPALCVSADGSTKRFAICTADGQMVVPKTATIEGASKGKALQSLMHALQLSVRVPNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNV1</accession>
    <name>N1PNV1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_128562</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNV1"/>
    <dbReference type="STRING" id="675120.N1PNV1"/>
    <dbReference type="eggNOG" id="ENOG502S5AR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_3_6_1"/>
    <dbReference type="OMA" id="GSCMCGG"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME45087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="134" mass="14296" checksum="0F53650B13F8013D" modified="2013-06-26" version="1">MASGSCMCGAVNYKYEGEPAVTALCHCTDCQKWTGAAYTSNVVVPRTSFKVTKGQPKDYDAVGASGKINKHWFCSTCGSSLYTELEVMPDMTCVKSGSLDGGAANHPIGVEFYTKDRLNYSAPVAGADQKPEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP56</accession>
    <name>N1PP56_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tetrahydrofolate synthase</fullName>
            <ecNumber evidence="3">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_62741</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="3"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP56"/>
    <dbReference type="STRING" id="675120.N1PP56"/>
    <dbReference type="eggNOG" id="KOG2525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_0_1_1"/>
    <dbReference type="OMA" id="VENFKWA"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME44224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="480" mass="52945" checksum="E5A90AD58F12992B" modified="2013-06-26" version="1">MAILESRRRPNRPLVSAASAPKNRGVPSKVGMAEWLIALGHTEDDINSLNVIHVAGTKGKGSTCSFIDSMLRAHAIRTSLPKKIGLYTSPHLIYPEERIRIDFHPISRELLAKYFFEVYDCLPQLAVELDTTKPPTERGPRYLQLWALLAFHAFIREGVDATILETHCGGEHDATNVVSRPIVTAVTSLGMDHIDMLGPTLEDIAWHKAGIYKRDAIALSTTQTPSALDVLRQRAKEVEAGLVVVVEDPRLPAKASQLVPSVQRENASLAAAAAQALLKRTAPDGQHGFTTEDIQNGVENWSWPGRYQTLSRGRHTWFLDAAHNEMSITLAAEWFEQTSREFANESDDIVRTIVFSHINELRDADALLERLTVSLKACNVNVQHVVFTTYADTPEFTSKQAQVSQYFAKIWQRSLPATLIAHELTIKGAIDRVKSFAVGDSVSHTLITGSQSLVGPALRLLRQDDSRPEASEGSSPVGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPD4</accession>
    <name>N1PPD4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_130287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPD4"/>
    <dbReference type="STRING" id="675120.N1PPD4"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118853_2_0_1"/>
    <dbReference type="OMA" id="RYKFEAW"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME44240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="92" mass="10119" checksum="B4E3379AE951B247" modified="2013-06-26" version="1">MAPSAEFTKAADDSKKLKQKPNNDELLELYALYKIGNGEDISKVSKPGMFDLTGKAKYNAWQKEVEAGTSAADAQKKYVAKVKELQSKYGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPG2</accession>
    <name>N1PPG2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPG2"/>
    <dbReference type="HOGENOM" id="CLU_1652107_0_0_1"/>
    <dbReference type="OrthoDB" id="3634131at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="160" mass="17608" checksum="ED0F7167744EFB0D" modified="2013-06-26" version="1">MDRPSNVTSTSKLEPQPTKGNSLTSDNMAKGESSGKVSMSEKVRAKISKLRKKPHVSDEQRLQAKIDSLHAEAGELHGECTRLQGAPSFPDISCTCCSPCLQTNQQPSRPAPKPPQLQSKLPPNVTLSSKEPRPLRQVTMKRNSRQGTCCWVIGISMRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPN2</accession>
    <name>N1PPN2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_44627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPN2"/>
    <dbReference type="HOGENOM" id="CLU_1310089_0_0_1"/>
    <dbReference type="OMA" id="GGTKHVY"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="210" mass="18220" checksum="A1924E3C42BFE2D3" modified="2013-06-26" version="1">MLTGSVSGSAHGQSGASVGSASSGVSHGNGKGSASGSVSGSAHGQSGAGVGSASSGASQDSGKIGGSASGSVSSSAHGQSGASIGSASSGASQDSGKVGGSASGSVSGSVSGSAHGNSGAGISSASSGASKDSGKVGGSASGSASGSVSGSVQGSSAGDASYSSSGASKDNNGSENASVYGNADGATLGSSNSMLGGGKTVSSASGGKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQG3</accession>
    <name>N1PQG3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQG3"/>
    <dbReference type="HOGENOM" id="CLU_2003862_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="124" mass="13383" checksum="E07045E7196B491C" modified="2013-06-26" version="1">MTSPGNTTSPSNTTNVTSTVNTTTHYPRTDSPSTQHGGAGKLLKRAWVAYKDWVKDLPSSLVSQNQPVTLPLPGPKKDVQERQKMGGSLIRRPRVMAITVTSADGATVHLEIPEGMGREDVDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR47</accession>
    <name>N1PR47_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_44100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR47"/>
    <dbReference type="HOGENOM" id="CLU_2291628_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="101" mass="11279" checksum="F46BC0B7CE9593A1" modified="2013-06-26" version="1">MPKRFEKDIVDGAQGYHVPQGFGVAMAALTIVMGERPSLPEVTMEDSFRKDSREDSHGGTTFTLRRSTMTSSLPESPWTCGKSQQAVEEPKETSRMNQQAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR91</accession>
    <name>N1PR91_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_32616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR91"/>
    <dbReference type="STRING" id="675120.N1PR91"/>
    <dbReference type="HOGENOM" id="CLU_826460_0_0_1"/>
    <dbReference type="OMA" id="QQMWRIF"/>
    <dbReference type="OrthoDB" id="5303367at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="80"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="336" mass="38090" checksum="C0AC7A73277CAD7B" modified="2013-06-26" version="1">MQRTLGIDGARTCGGPTSEQLQAEATITKHPTPPVFKYEALEPDAIRLLKWCTGSKAVDPHFELVTSRYLPHTQKYDVPYNALSYCWGHATHPKNLWSALQSIVYPEKLEMRRSGLLWIDAICINQQDIEERSSQVQQMWRIFNNATVIAWLGDSNEQVYASYFQCISQCDWPPKLRTSMEPAMKDILARQYFSRAWIAPELTQASRVDFLCGNRAHWSHEALSSLADQLAKESLGTNEVRSANLIRSAALGNRFEEEGNDAGSIFNRVFEAFYEAGCTDRRDRIFAMLQDPRIRRLSLSLKPDYSLSENDLWLALGQACGEDDAIREDAIKGTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS29</accession>
    <name>N1PS29_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_79295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS29"/>
    <dbReference type="eggNOG" id="ENOG502SKBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070095_0_0_1"/>
    <dbReference type="OMA" id="IMNAFNE"/>
    <dbReference type="OrthoDB" id="2592744at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="313" mass="34646" checksum="4D14F673A5A9B6D9" modified="2013-06-26" version="1">MAVAWQLANRASVADLNAFIQAIFPIRLGDVPFLYHIPYSRSFDAANFFVSSIVLSITPTAGFYASLHSGTKIGFLHRPFNLDRREVPRLSTILANHKGFDEVLTVGNNVALAGRLGLDPRDAHIVQGYKGDPDRCIGLVGALRQHTQAAEVKSRVLHEFCGHFEGCFGFGDEDSAGEDEPSCDDDVLHAIAIMNAFHPEEVDRVLEISQQNGLLANKTDAKGLLYVTGAVREPGLRYSRERGIKVICVGHRVCEEWGIRHMAERLRERFPGLRVDEIYDEEEPREQLRRGKTGEQKVVDNTGNTGGLPVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS77</accession>
    <name>N1PS77_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_87625</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS77"/>
    <dbReference type="STRING" id="675120.N1PS77"/>
    <dbReference type="eggNOG" id="KOG2658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_0_1_1"/>
    <dbReference type="OMA" id="QGDGKPH"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="17">
        <location>
            <begin position="392"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="481"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME45215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="509" mass="55844" checksum="BC71E129D855D9D6" modified="2013-06-26" version="1">MLSTPAKQTLRAGATTASISKNAVRSLSTTAPTQISQDGQQKRGMATVQDAPPVHRHGGLQDQDRIFTNLYGHHGADLKSAMKYGDWYKTKEIIEKGHDWLISEIKASGLRGRGGAGFPSGMKWSFMNFKGWDDDTKPRYLVVNADEGEPGTCKDREIMRKDPHKLIEGCLVAGRAMNTTAAYIYIRGEFYHEAAVLQRAIQEAYQAGFLGKNACGSGYDYDVYLHRGMGAYVCGEETSLIESLEGKPGKPRLKPPFPAAVGLFGCPSTVANVETIAVAPTIIRRGAEWFNKFGRERNSGTKLFCISGHVNNPCTVEEEMSIPLRELIDKHCGGVIGGWDNLKAIIPGGSSTPILPKKICDDQLMDFDALKDSQSGLGTAAVIVMDQSTDVVRAIARLSKFYHHESCGQCTPCREGSKWTEQIMARFERGQAREREIDMMQELTKQVEGHTICALGEAFAWPIQGLIRHFRPELEARIQGHTQRSGGEALAGGWQHDAGKKGMLISPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU14</accession>
    <name>N1PU14_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_147714</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU14"/>
    <dbReference type="STRING" id="675120.N1PU14"/>
    <dbReference type="eggNOG" id="KOG0364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="OMA" id="CGGSTIR"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000037">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000073">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000023">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME45909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="538" mass="58657" checksum="A4F483B5387C2408" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU46</accession>
    <name>N1PU46_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane anchor Opy2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_70460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU46"/>
    <dbReference type="STRING" id="675120.N1PU46"/>
    <dbReference type="eggNOG" id="ENOG502RY3X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030352_0_0_1"/>
    <dbReference type="OMA" id="HMVCIAN"/>
    <dbReference type="OrthoDB" id="2402916at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018571">
        <property type="entry name" value="Membrane_anchor_Opy2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09463">
        <property type="entry name" value="Opy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane anchor Opy2 N-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME46463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="474" mass="50919" checksum="1B9729A33BBF2DEA" modified="2013-06-26" version="1">MGRGTNHQVERTLRAIFKRCVDCPTNETPTCPDCAKGEICSLIPQDCNNCAHMVCIANPNPAPANDKTNVGAIAGGVIGGVLFMAIIVFFLWRFWIKKRREQQELEAEEWEDDEIAQQKHTQQFNAMRSDAASTRTRGSIANSILSRASNIIQIAYIPGVTNRNGSGHNSLLSSAPVPPIPAAYRNTTPKSPLSNEGDALFFRPGDLRDSTYSDGSSIRSANNRDTQYTRQSITPSLARSSVMSDIYRDDATTEPMPPMPAQRLIRGAPKMVSVRSQGSSPSQSPGSESAPSAVKVMMPGQSSSNSSPSSNTGSFVKATPIVVGKSKGRFPIARQNSDSSSTPSARHVPAVPSPLVETLTESEDEEEHTRARRSLIQATPRAADPAPLIQPLESPFFDASEMQTPASSSAAGRPNPYAAMSKTVGHQRPVRSDRGPGGLSAVIEEAAKRASQDPEYDICGKRDSSPFSDAHAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUE0</accession>
    <name>N1PUE0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_50505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUE0"/>
    <dbReference type="STRING" id="675120.N1PUE0"/>
    <dbReference type="eggNOG" id="ENOG502T6JW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_977303_0_0_1"/>
    <dbReference type="OMA" id="FHISGEC"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36600" checksum="C0E75B824DAFCBE8" modified="2013-06-26" version="1">MASLAVESASLLSIPCELRNTIYAYIFEPNSSDAIRSIPAKPDELAVALRLQDPARYAAAYRSTHRACQQLRVLQTCRQIYNEAHLLALSSTPCKNMPSPCLRLAHKLSRERAAPAHLLRAPMDISADTLTPVLVDGDFAYPDVFDLRSRPLAPTKIAAIRHITISARTSKLRALNEAWCGLPFGHPSLRLETLTIVPNRAECHIRSMGEIADLSQSHTLAYSLSETMKSLRNVKCLIVRNDGCFNEVVWRLFYRSFVYRLWRWGGAICGIRFESGETQPGGSAVRDNQWFRVYTEDGDERGVECGMEVCRLVGQTGEVPDLNPAGVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUI5</accession>
    <name>N1PUI5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cercosporin MFS transporter CTB4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cercosporin toxin biosynthesis cluster protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_70575</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">MFS transporter; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin. The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl radical, superoxide, hydrogen peroxide or singlet oxygen upon reaction with oxygen molecules. These reactive oxygen species cause damage to various cellular components including lipids, proteins and nucleic acids. Responsible for secretion and accumulation of cercosporin, but does not play any roles in self-protection against the toxicity of cercosporin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUI5"/>
    <dbReference type="STRING" id="675120.N1PUI5"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="OMA" id="IACEPLF"/>
    <dbReference type="OrthoDB" id="3365399at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF12">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="113"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME46603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="618" mass="67491" checksum="BA92271EEF9828CD" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUJ5</accession>
    <name>N1PUJ5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_70581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUJ5"/>
    <dbReference type="STRING" id="675120.N1PUJ5"/>
    <dbReference type="eggNOG" id="KOG1204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_1"/>
    <dbReference type="OMA" id="LPRCANY"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF11">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME46608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="269" mass="30636" checksum="565FD4D238E62F9C" modified="2013-06-26" version="1">MPFRYNKVLVIGATSGIGLALSEKFVAEGSSVVATGRRKENLDDLVKQHKGKIDTVVFDITKLKDIPKFVTEVFAKHSDIDCVLLNAGIQRHLQWQKPENVDLDLLETEFTTNYLSYMHLTKALLPHLQKQAPRETSLVYVTSGLALVPIMSCPNYCASKAALHHMVLAMRVQLKEIDSNVRIIELLPPAVQTELHDDKHQPEFKGRGRQMGMPLNEFTEEAYAGLNSDDNEQIPVQAVKQFMGFYDWEMERQKKMMGMYEMQKKQQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVE3</accession>
    <name>N1PVE3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_125442</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVE3"/>
    <dbReference type="STRING" id="675120.N1PVE3"/>
    <dbReference type="eggNOG" id="KOG3904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018689_0_0_1"/>
    <dbReference type="OMA" id="IIMFPPQ"/>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME46913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="344" mass="38046" checksum="D45800F046D4D754" modified="2013-06-26" version="1">MSEKGRKAPAIPRPSASVLLISPQNQVLLLQRVKQSSSFASAHVFPGGNVSEFHDGRCPDPDHPSRHTDSAVYRLAAIRETFEESGIVLARNNGFGRLIEVPEKEREAGRKAVHGSEVKFETWLSKFGGRADLEGLTPFTRWVTPTNVPKRFTTQMYLYFLPTLGGTKLSEGEEGEEVEIPSPTTDGGKEHTTARFLPASAWCRLAQEGRIILFPPQFFLLHQVAQFLDSLKAPTEYGSIEREALPREELETRRKRLLEFVKSGSPPWTDMCISPTVLPARDGKKREDGRSVLGLSRPGPELEKQRPGPTGPTDQCVLVGFRKEGPRQVAVISREDALAGGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVI1</accession>
    <name>N1PVI1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_69427</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVI1"/>
    <dbReference type="STRING" id="675120.N1PVI1"/>
    <dbReference type="eggNOG" id="KOG1414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700588_0_0_1"/>
    <dbReference type="OMA" id="CNCKAIH"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="210"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME47481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="401" mass="44054" checksum="CE83BB3FD2616FFB" modified="2013-06-26" version="1">MAELQRPPPSDFHTHHRDCTAQHQDIPDSAFDPQSGFMFDDSNDEEFRNMQQNIASLSVIAEHNGQQHFPGMHGANQNLHPHGSALGESFGHNFVDPFVFDQNVAPDSSSWSASVGMHSDSAQADIASRRSTSVAHQFGQITPPDDNTLKPFALPPKALRVTPSSSAAATAKSERARNAANQRHAKAKKARKDSARSVESPEDEEDDEVEDKRERYREKNRLAAAKCRQKKKINTEDLEESARMATAENNKLRAEERELRDLFSNLRNQALAHDPSQGCNCKAIHNYNMLKAAETARGAMSGVHMATFPSPSVRSTDSASPVSIGGTSSRTHSFSGPQQSRHSRTQSSAGLSLGRARHSANNHGQFKFGQTPLAQSTQPAAGDQFSQFMRRSSDNQQLGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVJ5</accession>
    <name>N1PVJ5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_70395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVJ5"/>
    <dbReference type="STRING" id="675120.N1PVJ5"/>
    <dbReference type="eggNOG" id="KOG1737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007105_4_0_1"/>
    <dbReference type="OMA" id="SYFVRWV"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000369">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GOLD" evidence="7">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="232"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="568"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME46375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1016" mass="111749" checksum="E6870CC65C589AA2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW92</accession>
    <name>N1PW92_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bet v1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW92"/>
    <dbReference type="eggNOG" id="ENOG502RXX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124166_1_0_1"/>
    <dbReference type="OMA" id="VWHHIKL"/>
    <dbReference type="OrthoDB" id="10255646at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332">
        <property type="entry name" value="BLL4707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332:SF7">
        <property type="entry name" value="SRPBCC FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16750" checksum="2E3C8089A6AAA079" modified="2013-06-26" version="1">MSQAIPTSTSVTESAVIKSPLSHVWHHIKLQDFANFWSAITKSEFVKGASEETDIVKWTFKDGTVLEVKQEEHSSINHFITYSVITAEPKLDYSSVVSTIKCYPVTSGDSEGSTFVEWTGNFSSDAGADIIQDAKYKRREALADLAKAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX49</accession>
    <name>N1PX49_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial carrier-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_69812</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX49"/>
    <dbReference type="STRING" id="675120.N1PX49"/>
    <dbReference type="eggNOG" id="KOG0769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="OMA" id="QFMMYEL"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000119">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000152">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="39"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="134"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="244"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME47997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36624" checksum="44F074EC192D90EE" modified="2013-06-26" version="1">MSAKARSTDPYAKEYTENPPTNPQQSQSVGTLSTAEQQSDNVAHALAGAGGGLFAMALTYPLITLSTRAQVEKKRANTGTLSAARRIVDREGIAGLYAGLDSALFGITVTNFVYYYWYEFSRSFFQRSTGKKQLSTLESMAAGALAGSATVLLTNPIWVINTRMTARENEASDGDLPTTEKQKKALRPSTISTLLKIIREDGFLRLFAGVLPALVLVINPILQYTIFEQLKQYVEKRRKVGPTDSFVLGALGKLAATSITYPYITVKSRAHVAQSNAPKLGMTATLKKIYNEEGIGGLYGGIGPKVTQSVITAAFLFAFKDALYDVTVKARRKAALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXA7</accession>
    <name>N1PXA7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LDB19 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXA7"/>
    <dbReference type="STRING" id="675120.N1PXA7"/>
    <dbReference type="eggNOG" id="ENOG502QS9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026015_0_0_1"/>
    <dbReference type="OMA" id="MVVAEEW"/>
    <dbReference type="OrthoDB" id="3832628at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024391">
        <property type="entry name" value="LDB19_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13002">
        <property type="entry name" value="LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LDB19 N-terminal" evidence="2">
        <location>
            <begin position="135"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="577" mass="62771" checksum="1B2E31A9572424B7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXC9</accession>
    <name>N1PXC9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_94498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXC9"/>
    <dbReference type="eggNOG" id="ENOG502RZ32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3037804_0_0_1"/>
    <dbReference type="OMA" id="IVWINYR"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME46884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="56" mass="6401" checksum="33BA6047B8E379F5" modified="2013-06-26" version="1" fragment="single">SLALYSFEPENDNELRLTEGQTVLVAYRHGQGWLVAENPETGEQGLIPEQYVRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXH0</accession>
    <name>N1PXH0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_146525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXH0"/>
    <dbReference type="STRING" id="675120.N1PXH0"/>
    <dbReference type="eggNOG" id="ENOG502RZG2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016574_6_2_1"/>
    <dbReference type="OMA" id="PKQACDN"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020448">
        <property type="entry name" value="Maltose_ferment_reg_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF18">
        <property type="entry name" value="MALTOSE FERMENTATION REGULATORY PROTEIN MAL13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00054">
        <property type="entry name" value="FUNGALZNCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME47678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="675" mass="75614" checksum="0DEFFA075AE7011D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXI0</accession>
    <name>N1PXI0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_87338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXI0"/>
    <dbReference type="STRING" id="675120.N1PXI0"/>
    <dbReference type="eggNOG" id="ENOG502SHWY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002341_7_1_1"/>
    <dbReference type="OMA" id="GQGIFHI"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="101"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="365" mass="40693" checksum="9DFC3EED25F90121" modified="2013-06-26" version="1">MTAHTASVGNQYDEIHISGSARAHLGDIYNTAVVDPIDKILDQLSYPGMYDWRSRSIDAHEGTFQWILEDSQKLLSDVMPSQRDEASSKGDVTVAKNKTEQSRKLQDWMRSPLDRNVFWIRGKPGSGKSTLMKTRSQDEKTTKLVAESSTLGAEVIVLTFFAFRAGSELVSRLTGLWRSLIYQVINSCRAVLGNSPTLNGWSEAKFPVASGARLLQALKSLLAEIGKQRTFIMLLDGLDEIADDDHLDMITRVKELTEFAKMCVASRKESIFDNAFGHSSRHLALHDLTAKDIEKVIYSKLSATQSNGQLLDDVDLQTLAKKILSQAEGVFLWVDLVLNSLCRGLNNGDDKEFLEDRLEATPPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXN5</accession>
    <name>N1PXN5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_42105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXN5"/>
    <dbReference type="eggNOG" id="ENOG502SJ1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013199_0_0_1"/>
    <dbReference type="OMA" id="YVQEMPP"/>
    <dbReference type="OrthoDB" id="5333304at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="868" mass="95115" checksum="C264CF96028BAD13" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXV1</accession>
    <name>N1PXV1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_31549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXV1"/>
    <dbReference type="HOGENOM" id="CLU_1073725_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="259" mass="28558" checksum="734E1F4E0A6F4172" modified="2013-06-26" version="1">MQGRTWRSSELAKRRLLQASTSAQQTCASWYEICLVVQAALSLTRRADDGPEVVLGRQAVPVHADDCNLPIFKEHRIHTLACQVHIDLDHLLNTLVLTRHPQPTSTAGISSTTISVAPRKSFGGGIFIAYECGYHVPQCTLGPCPRIQTQNSAMAFAARSDVLTSRQIALRNLRLMQERVSQYISFPVTGSGVNAIVIRTRSLDSLEIKLIVDAQDVTINRTRCIMHPAVVQRLDLDEQQGQSENGSPRLGFQQEASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY23</accession>
    <name>N1PY23_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_21093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY23"/>
    <dbReference type="STRING" id="675120.N1PY23"/>
    <dbReference type="eggNOG" id="ENOG502SUBI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085820_0_0_1"/>
    <dbReference type="OMA" id="APSHHYH"/>
    <dbReference type="OrthoDB" id="3639334at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095:SF1">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="189" mass="20459" checksum="B22FECB4B8BB874F" modified="2013-06-26" version="1">MPTQRPFLSNFLTAFRAHSQPLPKSTPSISTSAAAASSATIWSTAPPQPHRPPPPGSEVTVTSPKPINGKSNPYVQTTTAAQDRQLVSSLAPLQHNVSPQTHLPRSPPSPGPVYGPQNKPLPSYPSAQDVRRSRRGSDSSSEGFREVRGAGEKWFIGGLTANGDERYYKLSMVKRDKSLDRISTDQMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYE5</accession>
    <name>N1PYE5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM3</name>
        <name evidence="11" type="ORF">DOTSEDRAFT_124864</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYE5"/>
    <dbReference type="STRING" id="675120.N1PYE5"/>
    <dbReference type="eggNOG" id="KOG3460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_5_0_1"/>
    <dbReference type="OMA" id="FDSHCNI"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000036">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME47239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="95" mass="10671" checksum="B519FA9190C6BE59" modified="2013-06-26" version="1">MAESEDAGATPVNEPLDLVRLSLNEIVFVKLRGDRELQGRLHAYDSHCNLVLGDVSETVYVVDEEDEQENVRTVKKQSEMLFVRGDSVVLISPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYM4</accession>
    <name>N1PYM4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DOTSEDRAFT_123020</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYM4"/>
    <dbReference type="STRING" id="675120.N1PYM4"/>
    <dbReference type="eggNOG" id="KOG0539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034756_0_1_1"/>
    <dbReference type="OMA" id="WTIIEYV"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EME48078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="396" mass="45548" checksum="EC5447295ED154FD" modified="2013-06-26" version="1">MPGRTLPTLPSAEVAAHNTSKSCYVSVGTKVYDITPFLEDHPGGGDLIVKYGGKDVKEIMEDEVSHAHSESAWEILDDHLIGFVATEKVLEAVKESNDPFSVLPMEPTSKGMKVLEQASNGAAAEHKTVYESTGMSSEADLNKETDPTSDYKKHKFLDLNRPLLMQVFFGGFSKKFYLEQVHRPRHYKGGDSAPLFGNFLEPLTKTPWWIVPTFWWPPVAYGTFLCARYFTFPILAAYWITGLCIWTIVEYGLHRCLFHLDDHLPDNRYAITLHFLLHGIHHYLPMDRLRLVMPPTLFVVLATPFWYLAHTVFFYDWYAAVAVYCGGIFGYTMYDMTHYFLHHKNLPAYYRELKKYHLQHHFMDYENGFGVTSRFWDRIFGTELPPPPTPKVLKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYQ6</accession>
    <name>N1PYQ6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_67616</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYQ6"/>
    <dbReference type="STRING" id="675120.N1PYQ6"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_6_3_1"/>
    <dbReference type="OMA" id="HRVVIPL"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="297"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME48631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="419" mass="45407" checksum="33C5861F83C19DF3" modified="2013-06-26" version="1">MASLKIAISGGGIASLCLAHCLTRQHPQWEVKVFEAAPELREEGAAIGLGSNAQDALKLMSPSLREALDEAGGTRMDPSVRIMIGTGPESGRHVGDIRPKVAQIVVHRTSFWRQLRKRIPDGVLEFGKKLASVRALHGSDALVRLRFEDGSSYDADALVGCDGINSIVRGAILGEDHPAAKPVFTNGYNHRVVIPLSSAKEAFGEEYCSLRTQYGWVGKGGFLLTDHVENGEAMQVIAGRSDSGPWPYHSPFVEWDKARLRSDLADWGDIGKSMTKVFTEQPNLFAAGGRIHLETPTYAKGNMCMAGDAAQSFPPFQGAGAGQAIEDALMLSTVLSSCTSKDDMPRAFDVYDGLRRPRRSSIAQSSIWAAKLFTGRLPEVGLNIERMAERLPSWGSNIYEYDLAAAQQEGVARMKTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYU2</accession>
    <name>N1PYU2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_49042</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PYU2"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OMA" id="TFWACLT"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000854">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001471">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="845"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="888"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="961"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="990"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1068"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1106"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="60"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="388"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="848"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1165"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="733"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1447"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="745"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1447"/>
            <end position="1465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME48597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1473" mass="161824" checksum="706BFDB61EB034E6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZH2</accession>
    <name>N1PZH2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_76345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZH2"/>
    <dbReference type="HOGENOM" id="CLU_1294373_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="213" mass="24299" checksum="96D760D8B81EE4F2" modified="2013-06-26" version="1">MAWQSSAATAVQRSSTANDVRRLGEHSRQNEAERRRQAHVAHSYRLVTMDALPLSACHALNHSLVAAVLSRARMRRRRDYDDNDEIMVMMMTMMRRQDAATKLNQQLASQAPRRCRTRVQKKRFGFNRARLVHTPRPVRVAQRDRPLMRRQRRAGPDSPTPIVRHANACCSPYPHTVHTVPTNGCPLYIYANARRPDAWTVSSPSTAIRTPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZI6</accession>
    <name>N1PZI6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_39783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZI6"/>
    <dbReference type="HOGENOM" id="CLU_2151689_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="112" mass="12475" checksum="4B73AC207B0ACBA0" modified="2013-06-26" version="1" fragment="single">MPGFFESIDQLIDRSSTRHPFRTDPAYIGKLSGSRGTAQVVPQANLLRPVHDQMSYYYRSKHTWEIPQGQRHRIGCPPSKPTPSTARGGCHTSNSLHPAAVQTSRSQQIDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZQ5</accession>
    <name>N1PZQ5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_30273</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZQ5"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_831622_0_0_1"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME48917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36430" checksum="342A09F44559EF76" modified="2013-06-26" version="1">MSAWEHVNGNSSQPPASADSRTTYGFKVLLLQGQVRLPNSMLRATLFDTPPQVVTGSPHWSFFLGHCSDTIGRRLAFKFTLFLAGAFGLAAAGGPNRIGTCALYACVGLGWPVGQSIGSLNAWSFIPNTRLTGKAILRTHHRCDHVPHVPPPMLPFPPVRIAKTWLTEDVLNAMDGHPQDALKEQKLSVMAIIKRQLGKFGPECIAPLFSGWRLSINALLLWLMWTTIGLRYPLFNDFLPQDLPAAGVQSVPENTTHPDYAITSVVGVPGSILACYTVDLIYIGRKGPMAISYGVTTSSYQLTISSLEACFQNIMYRALYAYSPGVFPAPPRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q039</accession>
    <name>N1Q039_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_51275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q039"/>
    <dbReference type="STRING" id="675120.N1Q039"/>
    <dbReference type="eggNOG" id="KOG1890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006249_1_0_1"/>
    <dbReference type="OMA" id="YFWNRHL"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF7">
        <property type="entry name" value="SACI DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109472" description="SAC domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="3">
        <location>
            <begin position="282"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="HSac2" evidence="4">
        <location>
            <begin position="720"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME48020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="976" mass="108864" checksum="069C42806E0775B2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q062</accession>
    <name>N1Q062_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RPEL repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_120378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q062"/>
    <dbReference type="STRING" id="675120.N1Q062"/>
    <dbReference type="eggNOG" id="ENOG502SC67">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121574_1_0_1"/>
    <dbReference type="OMA" id="QCRPDAQ"/>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043451">
        <property type="entry name" value="Myocardin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793:SF12">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME48643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15136" checksum="7D4731017A1FD143" modified="2013-06-26" version="1">MSTTQVPDVVNDAPSTLERRNSLEKHLQARPTEQDLKDRHILLDTTAAPALQARAAELERQRITDNLKKGLEKRPEREELVERNVLPDTNAAPAIQGQQKELEKHMKADSLDKKLQHRPDKVELIREGILKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0N9</accession>
    <name>N1Q0N9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0N9"/>
    <dbReference type="eggNOG" id="ENOG502SZUX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093909_0_0_1"/>
    <dbReference type="OMA" id="RFCSHAV"/>
    <dbReference type="OrthoDB" id="5387413at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="259" mass="29677" checksum="359D72A62CD84DBD" modified="2013-06-26" version="1">MSSSRRHSMKPVIVEVKPDNPISNIAPASPSSPKAVRFAPEDRASRQLTSTEAWSLYHFENHARHCSACYYPLEVYRRGEQLCPIGHGLAYDVACHVYHLNGDVYSTTKDSNSKLVRVEVPHGYSQTRSLLRSMEHKLRSHRATPIVSYDRTYPISARKTWTPESEPENVILESATSSSRRRSVHRPVRYSTVVVADNDIEDVAAVTSKPSTTYTKERRGTLYERELQRKPKDYRVEIRGPSDTGKERRRHRDSGVFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0P0</accession>
    <name>N1Q0P0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_67789</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0P0"/>
    <dbReference type="STRING" id="675120.N1Q0P0"/>
    <dbReference type="eggNOG" id="KOG0459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_8_1"/>
    <dbReference type="OMA" id="ARFDECT"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="279"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="76"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="183"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME48843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="715" mass="78006" checksum="C53F884FE5840620" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0R3</accession>
    <name>N1Q0R3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_58159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0R3"/>
    <dbReference type="STRING" id="675120.N1Q0R3"/>
    <dbReference type="eggNOG" id="KOG0111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_27_1_1"/>
    <dbReference type="OMA" id="YKPVWID"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME48868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="149" mass="16363" checksum="6287C1A46754366B" modified="2013-06-26" version="1">MGDLARQKSTVFVGGLDSQVNENTLHDAFVPFGEIVEVSLPKPELKSNHDPHRGFGYVEFSLAEDAREAIDNMNQSELYGRVIKVNQAKPQKTENEGLGSRTAVWEQEGYAAKYNVADSEEANGDDEADKPLDPMQGLEGLDEAGPRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0S6</accession>
    <name>N1Q0S6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_30547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0S6"/>
    <dbReference type="HOGENOM" id="CLU_516804_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="527" mass="57373" checksum="2268924F73060C6E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0Y4</accession>
    <name>N1Q0Y4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_49623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0Y4"/>
    <dbReference type="HOGENOM" id="CLU_1194857_0_0_1"/>
    <dbReference type="OMA" id="KAFRTEH"/>
    <dbReference type="OrthoDB" id="3891490at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME49337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="232" mass="25818" checksum="66B8EDEBF0AF6FD8" modified="2013-06-26" version="1">MDYFHMSSVALANKIKQIKIFRVHSESGNTQSESNVDHIILVESALQGALAAMASDWTFEQTYLKALLHAEGSVTMRYSKRLGYDIDSWKMPMIVLDLGKTTPKQAIHAKIEGHGIDDINLLEIELEMYTTQLIGFGSNQLLRATEKAAHWSEEDSDQLRRLPSSTIQHIVEGAKEGDSGDVAQNTDSPADVEAFQIVNDVEDLLWTGVCPATQKDLSSMVFSRKARCMSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q142</accession>
    <name>N1Q142_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_111345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q142"/>
    <dbReference type="STRING" id="675120.N1Q142"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="OMA" id="WYSSASE"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="23"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="299" mass="34421" checksum="EBBA80B8249CABEC" modified="2013-06-26" version="1" fragment="single">FRLINTIDLSFHEFEHVESAPRYAIVSHRWGKDEITYQKFLADRYQSGQGNGWFKTIKGCNLARSFELSWVWIDTCCIDKKSSSELSEAVNSMYSWYSHSHECYAFLPDVLLTPTDEGFAEEFEKSVWFTRGWTLQEVLAPRRLLFYNAKFQLIGDKQQRRAEVAAATGIHANYLLGLDKVQDASVAERMKWAALRQSTRREDNAYCLLGIFDVNMPLLYGEGAKAFVRLQLEIIKKTDDESIFAWWQDMAELGSWTGLLAPTPKAFASSSDETIKILRGHWRQPFSMTNKGLKLKLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1C0</accession>
    <name>N1Q1C0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_107807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1C0"/>
    <dbReference type="STRING" id="675120.N1Q1C0"/>
    <dbReference type="HOGENOM" id="CLU_066042_6_3_1"/>
    <dbReference type="OMA" id="LAHCAFI"/>
    <dbReference type="OrthoDB" id="3639104at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="137" mass="15873" checksum="FCD7E994472397FD" modified="2013-06-26" version="1" fragment="single">PVPDCGENAADAIAKGCHFDVQTSAWVPEACRNDPKTVAEYNEWLWDPARKPRPFPYFADEAGQIWLQNEEVMSKHEGLVWTTWEEHLTHCAFMPRRYMRTWSQGRRIDHKMGNSEHARHCSGMLVNLVKNGMIYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1G0</accession>
    <name>N1Q1G0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_30410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1G0"/>
    <dbReference type="HOGENOM" id="CLU_1749590_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="149" mass="16834" checksum="9AF75290AC6ED270" modified="2013-06-26" version="1">MTRSLPPRKTLHPRGRESWHQVLCLIHELVFLTLFIEDPRPTLQDRGPKPSNFHFHSRNRSPLEHNHGPAIRTPPSPTPRPRASLLRCSKDVGIGHDLQGRLWCSASQLDSFPQAPRPPAAEEVVAREARRVCEADGFMEVIMCLLVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1K4</accession>
    <name>N1Q1K4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_20009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1K4"/>
    <dbReference type="STRING" id="675120.N1Q1K4"/>
    <dbReference type="eggNOG" id="ENOG502SRZH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609762_0_0_1"/>
    <dbReference type="OMA" id="NGRMPWK"/>
    <dbReference type="OrthoDB" id="3439209at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="48834" checksum="F8A2DDB69E901314" modified="2013-06-26" version="1">MQAPATPPTEQGLVDIGFEHGDAQLTAGRHEPSFLEQFLQYPEDSSVSLWRGGDVANPLFSGSFSSTNSFGSTGSFGGTSTNFGSNSSFSSNVNNSTLGSGPELSTVISNRLPTKVEPSPTMPTPTLLSQVVDTSQYENVENDAWMFSSVDYDAPSPASLGSMSNDPCTPVSPHGGDAFLRYPIGCNYLTSGRTMDGTCKYTGDGILTQVNTPVLDLPAASSRTSCECPGCTGSFPDQRPHATIWQATRPLALTQQSVSHHSHAHGLPFVTPTNLDGSVVPGAPPSLAIDPASMGTHPLPSMDRYTLEMSPEQDSESERESNPDVSDHAITEAAHRRSRDRYLLKMREKGWSYKEIKHRGNFSEAESTLRGRVRVLTKDKSQRVRKPEWTEKDLGLLDKAVRRFSGLDGSGRDRNGRMPWKKVSEWMSKKGSTYVFAPATCAKKFKELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q205</accession>
    <name>N1Q205_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_76930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q205"/>
    <dbReference type="eggNOG" id="ENOG502RKJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_624071_0_0_1"/>
    <dbReference type="OMA" id="VMPWISE"/>
    <dbReference type="OrthoDB" id="3642124at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="439" mass="49294" checksum="90FDA98F0A7F902C" modified="2013-06-26" version="1">MASRNRKPRTKSTPATYATTAARSESPDWLRELRITKAHHHLAGSSSEAIDLNSIRATETPTIEFIRPEQHQFPLVLYKCSSPVGTCVTVKGWLETNLGSNIDTALQIVRMEKQNLHLIADPGASGTLILLDHAAYMPIGDGSTPVSIMALLIPQDKYIRFFYSILPFTPLLHTLGDTLDNDGQPFISFKRAVGAYTESTHSVSDGPDRHCRLFFLIRETFERALRVPEHPDFINAESLTDYAPEISDPDTALHRLESDQFLLKEYPSSLDKIDLEQRTKDGVEITASDDRYVELLHPAERELAFQMELKASAYLLIKRNFFAAYYTEIQRIDKKPGQRVRTEYASQQWLEREYGWVNRKAKRLAVGWRLLGLLDESRVMPWISEGGSLGPSMRRRVEEDDDNDNDDDDDDEEGNVGNDGGGGGGNAAEVVAAAAQIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2B1</accession>
    <name>N1Q2B1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_40060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1Q2B1"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_0_3_1"/>
    <dbReference type="OMA" id="QIQATHQ"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903450">
        <property type="term" value="P:regulation of G1 to G0 transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000001">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000100">
        <property type="entry name" value="Cell wall biogenesis protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="3">
        <location>
            <begin position="764"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1210"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1275"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1232"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME48775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1374" mass="150361" checksum="FDAD380544AE12E3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2K0</accession>
    <name>N1Q2K0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_19212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2K0"/>
    <dbReference type="STRING" id="675120.N1Q2K0"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="OMA" id="QKISGYY"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF5">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="18"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME48694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="358" mass="37400" checksum="845CF6642E81BDFF" modified="2013-06-26" version="1">MVDIPKKHKACIYDEPGKVSTKIVELDTPEPGPGEVLINLTHSGVCHSDLGVMTNRWAGLPYPTQPGQVGGHEGVGKVVKMGPGAEQSSVKVGDRVGIKWISAICDSCPACHAGHDGVCFNQKVSGYYTPGTFQQYVLGPASYVTPIPESLPSDAAAPMLCAGVTVYSALRKSGAKAGDWVVLLGAGGGLGHLAVQIAARGMGMRVIGIDAGNKQDLVKECGAEVFIDHTQGKAEEEVKKVTGGLGAQAVLVLTAANGAYASAMGLLKFGGTCVCVGLPEGELKPIATAYPQFLVAKAQTIKGVAVGDRKDAIETLEFAERGLVKTHFTVAKMEQLTETFEKMDRGELIGRVVLDLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q307</accession>
    <name>N1Q307_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_67928</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q307"/>
    <dbReference type="STRING" id="675120.N1Q307"/>
    <dbReference type="eggNOG" id="KOG1395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_1_2_1"/>
    <dbReference type="OMA" id="VDTARHS"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="15">
        <location>
            <begin position="423"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="268"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME49050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="761" mass="81351" checksum="16449342FA850691" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q406</accession>
    <name>N1Q406_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_40641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q406"/>
    <dbReference type="STRING" id="675120.N1Q406"/>
    <dbReference type="eggNOG" id="KOG2095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022440_0_0_1"/>
    <dbReference type="OMA" id="MFKRQDE"/>
    <dbReference type="OrthoDB" id="447129at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000006">
        <property type="entry name" value="DNA polymerase iota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404:SF1">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="15"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="669" mass="75163" checksum="D59E7C06FFAE0C5D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q422</accession>
    <name>N1Q422_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_84844</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q422"/>
    <dbReference type="eggNOG" id="KOG1803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_8_2_1"/>
    <dbReference type="OMA" id="TIIHGPP"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18044">
        <property type="entry name" value="DEXXQc_SMUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="198"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="216"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME49460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="710" mass="77821" checksum="350418E86DD7BED2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q474</accession>
    <name>N1Q474_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_49782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q474"/>
    <dbReference type="STRING" id="675120.N1Q474"/>
    <dbReference type="eggNOG" id="KOG0528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_492721_0_0_1"/>
    <dbReference type="OMA" id="HNANTSY"/>
    <dbReference type="OrthoDB" id="2307332at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="162"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="162"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="516" mass="57519" checksum="070127C7FD21F02C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4V3</accession>
    <name>N1Q4V3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_85203</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4V3"/>
    <dbReference type="STRING" id="675120.N1Q4V3"/>
    <dbReference type="eggNOG" id="KOG2118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011310_3_0_1"/>
    <dbReference type="OMA" id="PLPRFQL"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="68"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="335"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="421"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="537"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="698"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="738"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME49920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="81198" checksum="0E8CA6A7C80CA88C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q531</accession>
    <name>N1Q531_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_68694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q531"/>
    <dbReference type="STRING" id="675120.N1Q531"/>
    <dbReference type="eggNOG" id="KOG2759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025709_4_0_1"/>
    <dbReference type="OMA" id="HSGHLRW"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000326">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="364"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="485" mass="54658" checksum="A18F3947C4EE685C" modified="2013-06-26" version="1">MSLDAPAYIVSLQNNIRARPISWEGAVRAKTITDEDLKKIKAIDKVRKEQRKATIEGNVQTYTDLLLGNAEGTKSIFESAAKRPDILQYMLVLTGDLVDDIPALTLSLIKHMHPYKPFLPLLKQSNNPEDPIPLLTSSVLSSLLSHAVIAQPKSNGEIDEALPKLYSYIAQLMQNSDPNLQDIAVQEYSALLRVSKSRQQFWKQRKETLSPLVDVLRNATGGKDSESTAYNGSSTAGSIRSIQTDSNVKISGVSLQLLYHILMVIWQLSFEGQLVGHGLDEEHDIIPLYAQLLRVSPKEKTTRLILGTLNNLLSSNKTALMPAALPAKLPTILTNLKSRHLTDQDLLEDLESLTNMVDEYTKTQTTFDEYSAEVKSGHLRWSPPHKNKDFWRENAQRIIEEDRGELCKKLAEILGKDWQNDKQVLATGCSDVAFLVKECPEKRQQLEKLGLKARVMALMQDENETVRWESLRAVGEWLRYSFDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5A9</accession>
    <name>N1Q5A9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_77364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5A9"/>
    <dbReference type="eggNOG" id="ENOG502SVDD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422824_0_0_1"/>
    <dbReference type="OrthoDB" id="5426563at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="677" mass="75268" checksum="C0433F31CCB8F7F6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2WM87</accession>
    <name>M2WM87_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Opi1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WM87"/>
    <dbReference type="STRING" id="675120.M2WM87"/>
    <dbReference type="eggNOG" id="ENOG502RG16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015714_2_0_1"/>
    <dbReference type="OMA" id="YSPRFKY"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="54881" checksum="72D530B11FF3A327" modified="2013-05-01" version="1">MEAVKETSKPPAYRQTSPEQVMWPSVPDHQPRPSSELTLPDIRTITSNEYIQHIDSPKSRHGSPVSVRSLPRIDPGTFDQSRASDTTMGSPIETGSVMSVDERPGRSTSADEITAAEALSGLGNPRHYARSSRGQNGHVSSHATSANGARGPEPLLELVSQAHPWVGGSIRGSMSVYETTKYYSPRIVQYGVNFMERNIGTPIVNTVGTVGTITGVEGQLRRHLDSRRPQDIEAGTAKSNGDVPMEVNGVEQLPPYPTSRPPSYREEPSPHAIDRSQDRPAANRTWSSRVFVTTSGLSVALSTTSRQSLRFCLKLLASQFQNVEHLTKALSMALNNYEETRKRVRENREADLEKGHRSTTPDQDDDARRLAQEIRQHCDTIWSTIQNVVQGVSRSVGGALPQNAREFVRAQLMSLPQRWRIVSDHQANVPSETSRAAQRMIDFATEGLDMMTQVSGVLKATLDSAEQWLATVGRRDATAQEDCAMSDAPAQQEHNEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2WMI1</accession>
    <name>M2WMI1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_25212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WMI1"/>
    <dbReference type="STRING" id="675120.M2WMI1"/>
    <dbReference type="eggNOG" id="ENOG502S8IP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071330_0_1_1"/>
    <dbReference type="OMA" id="ETWILRP"/>
    <dbReference type="OrthoDB" id="3535423at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF9">
        <property type="entry name" value="EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28175" checksum="B4AEE4413FC9FC0E" modified="2013-05-01" version="1">MKIVLTGCTGFVGTEILTQCIAHNYINHVYVLTRRPLNSQFSHKKVTQILHEDFEEYPDDLVNRLKDEGVEACIWAIGGKANQFKNLDEARRVGVNYPAQAAEVFAKQLATALKPYPGHPKNPPKPGEGRFPFRFVFISGWGACQDQFKRLWFMNDTRKIKGAAEKALLGVAANADDIEGHKCFETIVLRPGGVLAGGNDDMMTVITEGMIPSIAVGRLAKTAIKCAFDGGVDGTTILENKDCLGEGWAEVNSFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2XGA3</accession>
    <name>M2XGA3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_39636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XGA3"/>
    <dbReference type="HOGENOM" id="CLU_863367_0_0_1"/>
    <dbReference type="OrthoDB" id="3864188at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="322" mass="35797" checksum="F72A84D366D18C1F" modified="2013-05-01" version="1">MTERPSWITSPPSHHHYRAINARDTALPAPKDILSRRRKATESAEEGHITSQRRGPAWARSGLETLDKEIDNPAFPAPSSAQRTASISRSETPAVSRSRLEKQPKAFSKSSSMSLSATSNLYQKQPVDAKTANDIELGAILRGIKVFDNLPLHATIVKRPAGDWTELRYSECKGNYSLNTKKSSNGVNCLRLHLHKSHTKDKGDLASEKIVETSTFRELSNEKLYEIMRRGEAGYLVAKVNSRPITSSPAAAELLGGVWLHRSPSRRRLGRDHLPCLQRQLDKEKGEYIEGGVKGFADHLGDWHGEELVQSPRELLARIEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2XHD7</accession>
    <name>M2XHD7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_160547</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">May form a complex with LTO1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the YAE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XHD7"/>
    <dbReference type="STRING" id="675120.M2XHD7"/>
    <dbReference type="eggNOG" id="KOG4774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066684_0_1_1"/>
    <dbReference type="OMA" id="MHFQPVE"/>
    <dbReference type="OrthoDB" id="20086at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="11">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME38852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="195" mass="21350" checksum="0FE85DCD29C97CD7" modified="2013-05-01" version="1">MNTPVNNNDAIYHDTSHESEHIDPLDDVFGSAPSSPSLAARENRHAPNTEHSDIPRLRSIHVTSGYREGIAASKEQHIQAGFDEGFGLGGEIGIKVGVCLGVLEGIAKAIAKCEDGDEVKIRWETAKEEMKMERVLGEEYFGPDGIWKYEVSGQDGQGGEIVTFADIARHHPVLKKWREVVDGLAKDYGLVLETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>M2XI45</accession>
    <name>M2XI45_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_75031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XI45"/>
    <dbReference type="HOGENOM" id="CLU_2638038_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="77" mass="8259" checksum="0A04812BFD4230D0" modified="2013-05-01" version="1">MIDTAEHAHDKNSRVLTCTIDRVAATLSSSRGKFQALRHIIDICSSHAAGNDDSGMVRGCLSHTQDMLPPHIDSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2XJ01</accession>
    <name>M2XJ01_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XJ01"/>
    <dbReference type="HOGENOM" id="CLU_648939_0_0_1"/>
    <dbReference type="OrthoDB" id="10639027at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="423" mass="46235" checksum="F3C4F37290D1AA71" modified="2013-05-01" version="1">MARKIVCLRPTESSDRVVQHLTKTCLHRHAMAKGVSRKTARSRQESSKSALNLLSVASALSDIVVPDFKAVRSDALDKKTEPGESHRVPSVSKPAPEQLFDDSRSTRPNTLTRLDSSSTSCHGKPTQSRGVLQGKLSSRRQELAPSDKDRTISNRDTGSRRQHQPVDMKSRSSSSDDAPYPSGNHSGGSPQYEARSSGSLQASKLQLSGLHVLFELTPSDFHGHDAKSIGKAGTRPVASVEQQKNEVAQIATLESFSPCIGAEQEVVPVAQTRSDRGRSSEEETLQDELSHRQQSSLDAMQKFVRKERRLLAKALLQLPSSGKLDVKDVPDNVGEAMKLLLKDSRSFLQWTLKAKREQLEREDTAAKARDKSSETEVKSDCAAESEISIPGIRCAAMMVNDIARVVRVALMLIVAIGIILSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2XMH9</accession>
    <name>M2XMH9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_25580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XMH9"/>
    <dbReference type="HOGENOM" id="CLU_1652110_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="160" mass="17746" checksum="97B2D8E567F4640B" modified="2013-05-01" version="1">MAVDRNHHSDSERELNVHSETHPNWDDSFLDDAAIIDKRLSVVQLINKSTQRQITLNTRAADHFLEMPGLLENILLELGVQTVAPFKHASPTNTVDLSQLRLVSRVFDATIVGSTKLTAPLRILQVSTIPRGLIAAAWLLRELGYTDLEVGSCLTVVEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y0T5</accession>
    <name>M2Y0T5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_92199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y0T5"/>
    <dbReference type="STRING" id="675120.M2Y0T5"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030880_1_0_1"/>
    <dbReference type="OMA" id="HDKRMLV"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF57">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="399" mass="44432" checksum="D137C3747033C903" modified="2013-05-01" version="1">MASSLRPLSTLRAQVPLQWHRTFQADQKPKPAGVPHYAFAFDIDGVLVRSSAPLPGASQALKYLQNERIPFILLTNGGGKSEEERVADLQNKLDVELDTSMIVQSHTPFADMTDLHDKTVLVAGGDFDKCQLVAQKYGFKNVVTPGDIVVAYPDIWPFANVFLDYYKSFAKPLPKPIIPHSTSSDALKIDAVFVYNDPRDWGLDSAVILDTLLSSQGYIGTLSAMNGNASLRNRGYLQDGQPHLYYSNPDMWWATSYHLSRLGQGGFEAAFAGLWHSVTNGAKLSKTIIGKPHQPTYEFAERRLRAHRKALFGQTGLRDPLRNVYMVGDNPESDIRGANDYKSQYGSKWTSILVKTGVWKEGTEPAHKPDVVRENVLDAVRWAVEDARGREDVSTRHMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y2Y3</accession>
    <name>M2Y2Y3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_28774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y2Y3"/>
    <dbReference type="HOGENOM" id="CLU_921410_0_0_1"/>
    <dbReference type="OMA" id="VPENHAT"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="302" mass="33795" checksum="A7F413C80209459F" modified="2013-05-01" version="1">MSSNSNKVIRAFTDWPSSYPCPVGGDVLPCKINPPPSPPTLEIIVMCGSDYSSISAIAARLAEGLQGYHHIDVLSHLLKLNDLPHGDSYKKKALRNVDQYSLEALTKRRLWPPVLHLVDIIQQHIDEQVAVGRRKFVISDMRQDVDTLWEFSRKASCRRLETLALVLESQLIFSQVAEPNAIIFFAGSQPEQWHGQVADYYHRKNDDKVLAIPVVNGDVEQTYRRLLLALARKAHSSSVGVSQPSHELVDTQKMEEHKNDISAAAVAQESKLERKDTAVRNDGGENLLDELEHALRPNAQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2YK08</accession>
    <name>M2YK08_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_139030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YK08"/>
    <dbReference type="STRING" id="675120.M2YK08"/>
    <dbReference type="eggNOG" id="KOG1462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016743_1_0_1"/>
    <dbReference type="OMA" id="NCVINPK"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="10">
        <location>
            <begin position="423"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="498"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME39286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="574" mass="63123" checksum="3D566BEBF2E0B366" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2YM65</accession>
    <name>M2YM65_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_89057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YM65"/>
    <dbReference type="STRING" id="675120.M2YM65"/>
    <dbReference type="eggNOG" id="ENOG502S4TI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016107_2_1_1"/>
    <dbReference type="OMA" id="HATMNFG"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01297">
        <property type="entry name" value="D-aminoacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="2">
        <location>
            <begin position="70"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="587" mass="64630" checksum="79DD7E0897C6F492" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2YPN3</accession>
    <name>M2YPN3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_80915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YPN3"/>
    <dbReference type="HOGENOM" id="CLU_1434417_0_0_1"/>
    <dbReference type="OMA" id="DDAPMQK"/>
    <dbReference type="OrthoDB" id="10590470at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="189" mass="20895" checksum="51179269B186DCE2" modified="2013-05-01" version="1">MNDKASKPEKKGIARAIKKSTRATMTATTSQRASRRVSKAKFPGSIEEEPKSDKGPEEEDDGDERHSKDMPDDAPMQKIKSKPGKDSRPSAKMADIPEAEDDYKDEPPTKTKANATNKSSMKAPQVSEDEEIRYFDRIYVAAHKDTENFHHRGAGRWASGLPRPEAKFKTACVGPGAEAWKAAHKDNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2YPW3</accession>
    <name>M2YPW3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YPW3"/>
    <dbReference type="HOGENOM" id="CLU_2775909_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="69" mass="7740" checksum="F3BBAEF7DF306D97" modified="2013-05-01" version="1" fragment="single">MPGFAETVLDFHEKYDDDASHPDIVDAGDWIVTAKVGKEIRAQQREQIAALGIRHWCKLYVSRRGGGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBW1</accession>
    <name>N1PBW1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBW1"/>
    <dbReference type="STRING" id="675120.N1PBW1"/>
    <dbReference type="eggNOG" id="ENOG502RXBQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030124_0_0_1"/>
    <dbReference type="OMA" id="LWKACSY"/>
    <dbReference type="OrthoDB" id="3629525at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF13">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="419" mass="47978" checksum="C5EEBB7B3B656C44" modified="2013-06-26" version="1">MAGRQYGLVWDEVLGGVEPRWSAEPDLEQIEQLSRQSLHIAKDDNCTVKFYAQGGFNKLYTVEANGRGWIMRVALPVDPYRKTASEVATIRFVHRSTSAPLPDILSYDASNENGLRFEWMLMEHMPGTVLERSWRTISLSQKVALVKKLAQYQSELFHNAHRFQHIGNLFESQSSTYKIGSIVSMTFFWGDRGARDVNRGPFGTSYDWLSARLQLVLEDQDRILANTEDEDELDDAQAAKALAERLIALLPKILKSDDTEPTMLFHDDLHEKNILVDHVGNITAVLDWECVSVLPLWMACQPPALLNGATRLAEPQRKDYGAYDPEVDDDDAEFNQGLSSSYWNDVLMYERGHLRDVFLSEMERLEPLWIVEYQAGELKRDFELAILHCGSEMTMKRVETWLDAREEGESYSLRESLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC26</accession>
    <name>N1PC26_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-rrna processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_75917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC26"/>
    <dbReference type="eggNOG" id="ENOG502QZVV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006918_0_0_1"/>
    <dbReference type="OMA" id="HYNITKL"/>
    <dbReference type="OrthoDB" id="5596576at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059065">
        <property type="entry name" value="Ig_Tag1-like_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059066">
        <property type="entry name" value="Ig_Tag1-like_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055011">
        <property type="entry name" value="Tag1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF3">
        <property type="entry name" value="PRE-RRNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26174">
        <property type="entry name" value="LEA-2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26150">
        <property type="entry name" value="LEA-2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26153">
        <property type="entry name" value="LEA-2L_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22786">
        <property type="entry name" value="Tag1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1 C-terminal" evidence="3">
        <location>
            <begin position="458"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fourth Ig-like" evidence="4">
        <location>
            <begin position="603"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fifth Ig-like" evidence="5">
        <location>
            <begin position="744"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME38561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="874" mass="95048" checksum="69F9A309913F6A76" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC31</accession>
    <name>N1PC31_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metal-dependent protein hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_75920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC31"/>
    <dbReference type="STRING" id="675120.N1PC31"/>
    <dbReference type="eggNOG" id="KOG2948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051576_0_0_1"/>
    <dbReference type="OMA" id="FHCDEVV"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME38566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40402" checksum="86188768FD8F42AE" modified="2013-06-26" version="1">MSAPASKRVKMSNGTAAPVIGTHNGHFHADEALAVYLLRLLPEYHNASLTRTRDAEVLNDCDIVVDVGGIHDHSAKRYDHHQREFNATFPGKQTKLSSAGLVWMHYGKHIISAVTALGVEDADNELLYQEVYEDFVEAFDGNDNGISTYDPQELRKAGIEKKFNDGGFTIASVVSRYNRAPVSQLADGKPAGNGAPPAQGKPGKTQDEEDNRFLRASAFVGEQFSLKLTDMFTSWLPARAVVAQAFNSRHAVDASGSIIVIPYKPEGVPWSDHLYSLEEEHNVKGNVLYALFAENGEPDSKWRIRAVSLELGSFENRKGLPEAWRGVRDDELSKLSGISGCIFVHAAGFIGGNKTFEGALEMAKKAVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC75</accession>
    <name>N1PC75_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_74627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC75"/>
    <dbReference type="STRING" id="675120.N1PC75"/>
    <dbReference type="eggNOG" id="KOG2512">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032612_1_0_1"/>
    <dbReference type="OMA" id="YFQHEIT"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031925">
        <property type="entry name" value="TBCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16752">
        <property type="entry name" value="TBCC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="8">
        <location>
            <begin position="194"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME39787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="393" mass="42899" checksum="3206035FD40A49B1" modified="2013-06-26" version="1">MAAATAEDLVPAVQLPANEKFFRYFQQEVTDLQEQMARIENHGASGGERSDAVDHVRSVIARLSGEVQDASSYIPAYDQRTYGEAIKALNNKLQEVKMANAPRQKFSFKNRQLFSAVKNESAISLSDAAELAKQKRNHIPGFLADLSNTSSYVNTPASNTRTPANEKEDDELATHDSRPEVATSSSNGHLTAAPAGVRTLSFSGNNAVFIHSHDNVHIMLPSAASDTTGSGTVSDLDRCVVDMSTPATTGKPFAGLTLKNITSSLVICGHVGGAAHLTNIKDSVIVVATRQFRMHESSNCDVYLLATSRPIIEDCSAIRFAPMPHTYTTEEDKDIDNKWSNVDDFKWLRNEQSPHWSPLDPSKRVAEKVWKDVVPGGHDLSIENILDAVNVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCD8</accession>
    <name>N1PCD8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_75868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCD8"/>
    <dbReference type="STRING" id="675120.N1PCD8"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023057_1_1_1"/>
    <dbReference type="OMA" id="GTLCEFY"/>
    <dbReference type="OrthoDB" id="261960at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="37"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME38483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="53525" checksum="D725A0A6FFD358BF" modified="2013-06-26" version="1">MSWHPGGPMGIPHGDLSGRNRPASNGGPSGVQRSSASQLKENEPMFTTYEHLQGLPRTDAALAFLRKIASAVKPIMKKRGWRVQILAEFLPTDRSLLGININKGYKICIRLRYHTNPDLFLPFEEVVDTMLHELSHNVWGEHDSNFHKLWDELRDEHEALIRKGYTGEGFLGEGQRLGGRGYGRPPPLDEMRRRARARAEERKSQGTLFHGSGQKLGGTPLHARGADVRSVIADQIIRRNTMNKGGCGAGRQDAGKIADDAAKNTFSTKAEEDDANNRAIAQALYELMEQEETEKLKGTFKDASKPGAGLSWSPEQGLYDSKLSIPYAGAQPSEEEQLKWAMQESMRNGAASNSAMPTRPIKHEIIPDQGIQLEATPLIDLSSLPEQSNDVTDDQWTCEICTCINPLQYLQCEACGVERPQRKARKVKAETAASKKPVRKELQPSPSANRQNKSLGWKCRCGAFMEHQWWTCSACGNMKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCM2</accession>
    <name>N1PCM2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_158281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCM2"/>
    <dbReference type="STRING" id="675120.N1PCM2"/>
    <dbReference type="HOGENOM" id="CLU_953409_0_0_1"/>
    <dbReference type="OMA" id="CERECNP"/>
    <dbReference type="OrthoDB" id="3251507at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="325" mass="36882" checksum="3B80E6441591C9E2" modified="2013-06-26" version="1">MSFTRDAFFTLIIERCKKRIQNYRKRLSSCVGSMRSQLAKHSRIDEALRALLTIHDHKEFASQAYRFRKMAACKDLDDLADQQAVYSSWSDLRHLIGRCGSWYRAADFLVRHSPDFRDILQRCSIHGLSNISDYPAFNIEQNIRVLLEQVCSLPRPETDNAVRVLSTASGTREALAKVQKPFVHAEAAVAKHFSTQDFAFVGSDRYIGCSKPPCYCCQLYMKQSHINMGHKETSGRAWLKWALPNDDREGNEATGTYKLDDSKILSDMIDTMKSDVTRSLTHGQYGRKRKHDTTTGITPMIWEDSAQPESVRPSPAPALLQGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCR9</accession>
    <name>N1PCR9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_27797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCR9"/>
    <dbReference type="HOGENOM" id="CLU_1594493_0_0_1"/>
    <dbReference type="OMA" id="MIAQADN"/>
    <dbReference type="OrthoDB" id="3646601at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="167" mass="18614" checksum="D754AD349E8F1EBD" modified="2013-06-26" version="1">MVISGVPVAATAQNHKPCRLLGLPAEIWSRIGRSAIDDVPNVTAEMIAQADNTENTIIRRQSTDSKSPAPCNQLLAYYYQTKAGFQTNESSDVLASSGEWLRCVGAVNRRHILGITVLMDWNEDPAELKDGMQDPYWKGIEFRLVKVRSPIVDGDGYAWDKYKVVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD46</accession>
    <name>N1PD46_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_67137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD46"/>
    <dbReference type="STRING" id="675120.N1PD46"/>
    <dbReference type="eggNOG" id="ENOG502S0RY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_4_3_1"/>
    <dbReference type="OMA" id="FGTHKIN"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07253">
        <property type="entry name" value="GLOD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050383">
        <property type="entry name" value="GlyoxalaseI/FosfomycinResist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366:SF14">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="8"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME38359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="129" mass="14369" checksum="9E094D26D90F3C1E" modified="2013-06-26" version="1">MATFSVKSIDHVVLTVANIPKTIDFYTTRLGMEHESFTSKGTKRHALVFGKQKLNLHQSGQEFEPKAGRVQPGSEDLCFITDHPIQEVLKSWRDNGIEILEGGEIVDRTGAAGKLRSVYCRDPDGNLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD81</accession>
    <name>N1PD81_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD81"/>
    <dbReference type="eggNOG" id="ENOG502RM2X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_704034_0_0_1"/>
    <dbReference type="OMA" id="FEKNACK"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="44932" checksum="87511E5C35D32AF2" modified="2013-06-26" version="1">MVTTPRKAHKFSAYDIGNMEVMSIVDHERAQQQHLDRTMDSAVDQLEALTDPTMPRPEMVQAMVRFGAMKLDDIPLQFDFEPPTTSRIWPGPKYGPHSLHKRLHRPTKPRPSSVRKHSRNDDQRHAVRARQPPSMKQEAKSAEDSPSDLRSVAARDPPLYLLGLPPEVRNHIWSLLAVREGPIEAQLRQIQPCRRLSKHRCRTIRKFPWEPVVAGVNHQVRREVLSIFYGTNRFVFEKNACKMFEGYSMTNPTTMQKWSPSTEIANFLSHVDIKFNAWPKGSLDPVSIVFGLRKARDKKVTIDIAVEKTKKKKAAQVDRVCLCEELDAVEMVQSEVDKDLMHVATILVKKRNEISFSSPTLTMLSKNDKRYPQGETCTRCEKPTLEIVYSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDM5</accession>
    <name>N1PDM5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_136331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDM5"/>
    <dbReference type="eggNOG" id="ENOG502RNKY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1669360_0_0_1"/>
    <dbReference type="OMA" id="CTQELIW"/>
    <dbReference type="OrthoDB" id="3942519at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="158" mass="17439" checksum="AA94F714A2EE6C90" modified="2013-06-26" version="1">MCTQELIWCSCGHGEFLPIELCTTGQLIGTCWTIVHGDHNIVLQSRCSYCQAGLNRKGMLGSARPTDGIAERVEAGGRIGEGGMNGKEIDEFDGELGKLLEEVETKTKEERSFEKFSFDDVMSTDWEKGFDLSDELWNYDEFSLGNGVVGKGKGRGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE00</accession>
    <name>N1PE00_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_48641</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE00"/>
    <dbReference type="STRING" id="675120.N1PE00"/>
    <dbReference type="eggNOG" id="KOG1433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043547_1_0_1"/>
    <dbReference type="OMA" id="IACNALR"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="43"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME38415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="370" mass="38862" checksum="63C7B4763D58508C" modified="2013-06-26" version="1">MAVSNDIIDISSSAAPTQPPPSASHRLPTQSASTALLGLSRRGPSFLTTGIGSLDRQLAPQSRNGDGGLERGKIAELWGPVGAGKTALAFQTAKGALKRTAHVVWIDCATLLSGASAKGIADAADSFHYVAAPTLSHLLALIISPPAGLIPRGTVLLVVDGLNTLVDLDYPRLPYNSRARTDQQKGQAGRRYAILGSIMTALNKLAALHDLAVIVTTGCSSRMRHDSGLGASISPGIGGSEWENGISSRMLIFRDFDGRFIGVQRCLGRNVTPLDPVGDVRNVVGFEFTASGALEEHIIDLTSSTSDGATVQKPSVLPSPAKVVRKRIYDEIADSEDDEDEYGWAEADDVAIATQTMPERSASVKAADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE58</accession>
    <name>N1PE58_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE58"/>
    <dbReference type="STRING" id="675120.N1PE58"/>
    <dbReference type="eggNOG" id="ENOG502QRU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058495_1_0_1"/>
    <dbReference type="OMA" id="VPFHEFD"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="277" mass="31034" checksum="F4349FF3BA32BAD2" modified="2013-06-26" version="1">MGSAAVSDLKAMNEPFKNPKFIFFTDFDGTITLQDSNDFMTDNIGFGGEKRRQGNRDVLEGKDTFRDSFRKMMDSVIKPFPECIDYLVSNIKLDPGFNEYFQWALKNEIPTVVVSSGMEPIIRAILKNLIGPDHIKLDIISNQAEARPGKSIAQEGGWQIKYHDDSGFGHDKSLTLRPYAQLPKEQRPTLFYAGDGVSDLSAAKETDLLFAKKGHDLIRYCIKEDVPFTVFEDWHDIHAVVKKIVAGELSVHDAAKQGWEDYKNGAAGLKVENGKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PED3</accession>
    <name>N1PED3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PED3"/>
    <dbReference type="HOGENOM" id="CLU_2757761_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="70" mass="7338" checksum="E50D8EB7DB72532F" modified="2013-06-26" version="1">MPRTCPNSRRSRRPVSDALPFSVHRKGSSCEIGIASSCLGHPETVEPEGSRLTNTSGPCCPGIGSLCAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEU6</accession>
    <name>N1PEU6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_74447</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEU6"/>
    <dbReference type="STRING" id="675120.N1PEU6"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_475672_0_0_1"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME40892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="573" mass="63191" checksum="95BE91459189D453" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF24</accession>
    <name>N1PF24_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_179143</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF24"/>
    <dbReference type="STRING" id="675120.N1PF24"/>
    <dbReference type="eggNOG" id="KOG0361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_1_1"/>
    <dbReference type="OMA" id="HRKGNTW"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="526"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME40180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="559" mass="60870" checksum="4AF30DE0CB8E8D2A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF30</accession>
    <name>N1PF30_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF30"/>
    <dbReference type="HOGENOM" id="CLU_1447638_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="187" mass="21009" checksum="AC5EB15A13CAA256" modified="2013-06-26" version="1">MSRQDSHLHIMRSSSRPGEFRTWSLMKLSHLLIKVNALPRSQDEILPTHVRLEDVSRLPIKLTCSQCLSNELEYETYSLRHHILRRFPDVEETTSRPSPTIIAAKTAQHSTDGLAARARCGIDPPTNSCAAWCMPKLWRKSIAQLLNNLGEGTVFLLPDLLGGLQATQQPRPALLVVYNPESGRGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF81</accession>
    <name>N1PF81_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_137200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF81"/>
    <dbReference type="eggNOG" id="ENOG502S78C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065192_0_0_1"/>
    <dbReference type="OMA" id="KFPMTWP"/>
    <dbReference type="OrthoDB" id="5538558at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF39">
        <property type="entry name" value="THIOESTERASE_THIOL ESTER DEHYDRASE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32931" checksum="DD83B35C8F12759A" modified="2013-06-26" version="1">MANISGSVLRRAARTTSPRAPVSTHIACAKPYSIQPASQPAPVPSNPRWLSDVKHRIGHCITFGLTPSQNLEAFEIIRDFAVSWRELLAGSEGFLTGKHRRSMFRLPVVWGEQDSMGHVNNVVYNRYAETGRIGWASKYGRYIDPEHAEDWNGLWTPKGEGLILRKITTEFKFPMTYPDHVTIYHRLGTKPAEGTDTFDLHVIILSELHQRPAARVVEDCVLYDYIKRKKTPIQPFMLEVLRETWRLQEITKRENSERVSSLLDRVRQLELQSWDRADAVEYMGSAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG77</accession>
    <name>N1PG77_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG77"/>
    <dbReference type="STRING" id="675120.N1PG77"/>
    <dbReference type="eggNOG" id="ENOG502SSNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112091_2_1_1"/>
    <dbReference type="OMA" id="GHCYAAW"/>
    <dbReference type="OrthoDB" id="5313995at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF1">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="9"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="157" mass="17557" checksum="E5D768EF363BADD0" modified="2013-06-26" version="1">MASIKASDSIPYLYRFLLTNVESLAALGGIILILTNPGFYLGGMTREVITSYPSQYDFLLWQIAGGWAFIVFTESVILRFVDDLRVWRYLCMGILCCDAFYTQSTAMAVRGWGEWLDLGKWTAQDLVAAVMTWPFVLTRVAIVLGVGVKKPAGVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGF8</accession>
    <name>N1PGF8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_177384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGF8"/>
    <dbReference type="STRING" id="675120.N1PGF8"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="OMA" id="CCGGCVI"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME40411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23794" checksum="3C2F52E8DAFE64BB" modified="2013-06-26" version="1">MASKFLREYKLVVVGGGGVGKSCLTIQLIQSHFVDEYDPTIEDSYRKQCVIDDEVALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSITSRQSFDEIMTFQQQILRVKDKDYFPIIVVGNKCDLESERQVSTEEGRNLAHQFGCKFIETSAKSRINVDNAFYDIVREIRKYNKDMSGYPGGGGSGSKPKDEMGFQDQEQDAGCCGKCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH41</accession>
    <name>N1PH41_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_74427</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PH41"/>
    <dbReference type="eggNOG" id="KOG1240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001696_0_1_1"/>
    <dbReference type="OMA" id="ATNTCRI"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000497">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1097"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="779"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="896"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="940"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1484"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="947"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1011"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1485"/>
            <end position="1499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME40865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1551" mass="172008" checksum="F09FCEE4637F42F6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHA6</accession>
    <name>N1PHA6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHA6"/>
    <dbReference type="HOGENOM" id="CLU_2793951_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="68" mass="7660" checksum="74C73025248EB0BF" modified="2013-06-26" version="1">MAIMDERRGFCVGVGRGGDCWIVDCQRGRGFVLGKVDMPGELEQNWQKSNEQQRQVDVVFSCRAPGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHG4</accession>
    <name>N1PHG4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHG4"/>
    <dbReference type="eggNOG" id="ENOG502SR0R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095762_0_0_1"/>
    <dbReference type="OMA" id="HKANMLS"/>
    <dbReference type="OrthoDB" id="3942453at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="209" mass="23215" checksum="02090FFAFF4DDCA0" modified="2013-06-26" version="1">MCIAGLNVSTGACQHRWYELVSPCNPISNLANCSERLRLQGWEVRKDNCPFCDGENHHRSTHRLFGSTSSASSITSSPTISEIGVTPATRRGSMVTLNLNAGQLSPISRTISGCSIETERSRRNRDMNDRIRLYLSSEPHEVLPSARKNYPTYAAAVARVESGLAGKDQSDNAYTRLRRRSSVSSVGQGWKRFSERFGLINSSLHRIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHK4</accession>
    <name>N1PHK4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_73004</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHK4"/>
    <dbReference type="STRING" id="675120.N1PHK4"/>
    <dbReference type="eggNOG" id="KOG0004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_2_0_1"/>
    <dbReference type="OMA" id="GVFMAFH"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME42093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="155" mass="17816" checksum="7F5FC05AA467CA87" modified="2013-06-26" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMAKKRKKKVYTTPKKIKHKRKKTKLAVLKYYKVDGDGKIERLRRECPAETCGAGIFMAAMHNRQYCGRCHLTYVFDDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIF8</accession>
    <name>N1PIF8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_74083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIF8"/>
    <dbReference type="HOGENOM" id="CLU_1660720_0_0_1"/>
    <dbReference type="OrthoDB" id="10484097at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109865" evidence="3">
        <location>
            <begin position="25"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME41914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="159" mass="17872" checksum="8610EAA60C2CEFC9" modified="2013-06-26" version="1">MNEPLHAVPFLLASTASVLVCVIASSGLRCTIPTTNISFAVLKPMLPNQCTPELHRLEPDAWPCVRDGASQYIQRVVATDGWQHIQGPGLKYFLMFLSYFGPWLLIAVVHYLERYFERSTRVYRVEDEVVVAEAEELPREGTGGEKDDANPKQLPNERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIK8</accession>
    <name>N1PIK8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_73713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIK8"/>
    <dbReference type="eggNOG" id="ENOG502R9AF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_723667_0_0_1"/>
    <dbReference type="OMA" id="ALGVCEC"/>
    <dbReference type="OrthoDB" id="4764735at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="382" mass="44481" checksum="90BD2D5EAD45309B" modified="2013-06-26" version="1">MASSSQSRRATHTGFDQPEQVREDRRRSTSFSFLWRFTTMEEEATRWQATLHAVISTRQQSRERFRAAVGKHAKLCEHVGPQAMVDRVLNRFRKRKDTEGPLYELDKIREKLTTLALERRFAEDQVLATIRGFRLYTNQILHRLQQQAPHHNDPLFRHEHALHLARVNNTVMTIYYSHYFGERTYAGDTAKLTWQIWSSECIIHKKSKFACEAQKAVVVAERELQSAENEYQKVYQQWKEATNRYITALGEAAGVRNVFPNVGSGSSAHVDNVDLFKAELVHWVAHSKHVFADYTTLMTFPEPPRWRCSDVDGCQERRHGRALGVCECSVREAVKGLDREDLKWVRTHFHPDKFRRCPEEKRAVFGKKAGEVMIVVNEVWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIX7</accession>
    <name>N1PIX7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_134376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIX7"/>
    <dbReference type="eggNOG" id="ENOG502RHG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2757759_0_0_1"/>
    <dbReference type="OMA" id="QKCCPLK"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="70" mass="8355" checksum="5EC19796307E54C1" modified="2013-06-26" version="1">MCEHVRVLYKCGHLRFCVLCWCKCSKYTELQKCCPLKIQRYENLTRERCGKSAGAWSYLRRLIGSFRMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ12</accession>
    <name>N1PJ12_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_89790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ12"/>
    <dbReference type="eggNOG" id="ENOG502QS7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010399_2_0_1"/>
    <dbReference type="OMA" id="VEWMCVP"/>
    <dbReference type="OrthoDB" id="406733at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF0">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="TREH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trehalase-like N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="1">
        <location>
            <begin position="272"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="661" mass="75783" checksum="E634238EB42CDD6A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJE4</accession>
    <name>N1PJE4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_54646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJE4"/>
    <dbReference type="STRING" id="675120.N1PJE4"/>
    <dbReference type="eggNOG" id="ENOG502S3ZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640970_0_0_1"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109414" evidence="1">
        <location>
            <begin position="19"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="428" mass="46286" checksum="CC5ABEF7A3D6D551" modified="2013-06-26" version="1">MYLFRFLTILLLPILAPASPLVVSYPIPQNDFTCRSTTHQNPVVFFHGLGATYYEDLNYLQSHLQSQGFCTFSTTYGAYPAFPYIGGLKPIASSALELAAFIAEVQSKAGAIKIDLVCSSRIRPFPGHRTMTYKLTDPILPQVGHSEGAFLTLYVPKFTNTSSLIDKIIAIAPPTHGTDFDNLYDLAYLFGNASRETVGDVLNTVGCAACDELGPGGTAVTALTTGPIVQSGSSVTILASRYDQLVTPTGTSFVDEAGVRNLYIQQFCPSDFVGHIGEAYDPNVWDIVRKTLNGLDMDEVGPDVISMADTSPADPSVHKNDLDGLRSQIIANASVLFSTVHKKELGPGTAYAAGNDFEVLMDMDEVGTAGDSSRQEVRASVVFRRPGERSEQKKYRQAAPSLAFDTIHGALNSLLHALARALSPFKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJN1</accession>
    <name>N1PJN1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_155796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJN1"/>
    <dbReference type="STRING" id="675120.N1PJN1"/>
    <dbReference type="eggNOG" id="KOG2141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006786_2_1_1"/>
    <dbReference type="OMA" id="FMVDILN"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="446"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME42783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="679" mass="75563" checksum="5DA79A9054261580" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJS5</accession>
    <name>N1PJS5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJS5"/>
    <dbReference type="STRING" id="675120.N1PJS5"/>
    <dbReference type="eggNOG" id="ENOG502T7E0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1246217_0_0_1"/>
    <dbReference type="OMA" id="HINMCIL"/>
    <dbReference type="OrthoDB" id="3650515at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="217" mass="24950" checksum="75D9C3DE7F00602E" modified="2013-06-26" version="1">MADANAEQAFLSAIAQLAQRADLSDFTIICKDKEWHVHRVILASHSSVLNRACSGEFMEGRKKKYDLSEYDVGQVEALIEYMYTLEYQISDDVSSLEELCLHINMCILADKYDIPCLKEFATTKSKSCIDDVAVIEMAKPVTLVYEAEGATAEIRKALVQDLVHYDVFHAQKSYERRRIFETLLESYPRFAIDIIRAQSEFRKRLEDEWRTSCIPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJY3</accession>
    <name>N1PJY3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_155199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJY3"/>
    <dbReference type="STRING" id="675120.N1PJY3"/>
    <dbReference type="eggNOG" id="ENOG502SA9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022553_0_0_1"/>
    <dbReference type="OMA" id="FAEYHLS"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="604" mass="67197" checksum="39A807DF42CF48DB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK48</accession>
    <name>N1PK48_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_176057</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK48"/>
    <dbReference type="STRING" id="675120.N1PK48"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022048_7_6_1"/>
    <dbReference type="OMA" id="RLYCAEP"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="170"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="174"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME42772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="452" mass="51364" checksum="6C8C507A31902FD9" modified="2013-06-26" version="1">MASIVATDHHAFDEDIDLIAMQMEELELFTKNDKGKYCADDPPDLNLALQVYLEDLQTYKRYLDDHKLAQSIGIAVHQDEAMIAALTSEDLTAHEDRQMALRLNEDDANIQDPSQTSGIHQSLLDEWLSCATETITANSIVADSEDEDDQAGPSMTFAERQDDLMVKLSEGFTCSVCHERHRHAAILKLQCNHRYCITCAKELFVRATRDETLFPPRCCKKPIDPELVRGHLSSKERGDYDMASVEFATVNRTYCSNRQCGRFLPQALMDAASRVAVCSSCATSTCCICNNEAHEGLDCPDDPALRETRRVALENGWQTCPGCNGLVQLRSGCNHMTCRCKTEFCYVCGARWKNCPCDQADEGRMIERAEEVVDRDAEAELPRAERNRRVRVVHAGLQDNHECEHPGRFQRMFGGGRRGFQCEMCDVRHWKYILQCRHCYINVCEDCRRNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK58</accession>
    <name>N1PK58_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar sorting protein Vps3844 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_71638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK58"/>
    <dbReference type="STRING" id="675120.N1PK58"/>
    <dbReference type="eggNOG" id="ENOG502S64Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054960_0_0_1"/>
    <dbReference type="OMA" id="TTYWGGP"/>
    <dbReference type="OrthoDB" id="5583277at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053065">
        <property type="entry name" value="Archenteron_Induction-Rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024382">
        <property type="entry name" value="Vps3844_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853:SF1">
        <property type="entry name" value="DUF3844 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12955">
        <property type="entry name" value="Vps3844_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109429" description="Vacuolar sorting protein Vps3844 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein Vps3844 C-terminal" evidence="3">
        <location>
            <begin position="271"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME43897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="385" mass="41755" checksum="B222496CEBE2C5E3" modified="2013-06-26" version="1">MKINISTIIPALCCTAQLVAASSAHVYIHDPHSQPSTESRTLEPVAARLVLAQRAGVEDYHDADLLRQEVVKAINDYGLRTHLFEADSTVKRAMFLLEGESDPAATSSLLRTYTTFELDPAPAAPASRGLFVDLAKQSMPDRYSHHSDEALYIELQSVQRQSTDGAWFHVVGSMAELESLLETMTKDETWSITILVIPPGEQTAASQGKYQWGTYSMPNTQAPLEKRQRKISEEPLTESFEPVASSKTEFAAPISINANNTSPLRGILPACFSTQSACESATRNCTGHGSCSKRYHDSTANNKGGIDCFSCSCKATKSSDGKKTTYWGGPACQKKDISIQFWLIVLFTVGMIFLVGFAVGTIMDMGSQELPSVIGAGVSGPSARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM78</accession>
    <name>N1PM78_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Acylphosphatase</fullName>
            <ecNumber evidence="1 2">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_45971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1 2"/>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM78"/>
    <dbReference type="STRING" id="675120.N1PM78"/>
    <dbReference type="eggNOG" id="ENOG502S7SZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_4_0_1"/>
    <dbReference type="OMA" id="VGFRWSM"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268:SF4">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="5">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME42441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="90" mass="9718" checksum="A103B67025D46C65" modified="2013-06-26" version="1">MSKRISFKVEGVVQGVNFRSWTEQKANGLNVTGWVKNAADGTVVGEAQGDQSALEKFVQHLNIGPQPAKVKKVDQKDIDTKDGESSFGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM88</accession>
    <name>N1PM88_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM88"/>
    <dbReference type="HOGENOM" id="CLU_2512611_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="85" mass="9627" checksum="1BCC0136DF4B2D8D" modified="2013-06-26" version="1">MHKHYSPSPPYRSQHSTPSHNRAPAQHPPVTSGRTYGRFPGFAQSYLQCVRRVVTTDEGLIRRLPIWDIVHSSSSHPTTRARSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMQ4</accession>
    <name>N1PMQ4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_63066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMQ4"/>
    <dbReference type="STRING" id="675120.N1PMQ4"/>
    <dbReference type="eggNOG" id="KOG3159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_3_0_1"/>
    <dbReference type="OMA" id="RYQNWDW"/>
    <dbReference type="OrthoDB" id="3034343at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="64"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME44716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="411" mass="46184" checksum="58F6534FEA1CE1FE" modified="2013-06-26" version="1">MILRHHLIRSSHARGVVQRPLATRRWLSTSILEGLQKPVQSYISRSRDPYFNLSIEHYLLKKAAADSAVLFLYVNRPSIIIGRNQNPWLEVNLAMLDASRGRPATEPPGLGDVDLVRRRSGGGTVFHDEGNVNWAVICPSTKFTRDKHSEMVVRALRSCGVDRSRVNARHDIVLDQGHRAAKTDPDDTHSTPYEAIDFDTSKPLKVSGSAYKLTRNRALHHGTCLLSSPNLHVIPDYLHSSAKPFMTARGVESVSSPVGNILLSNDDFVAAVQKHFIKNYETRSLPAVEVDEDWLDDQEIRKGYEELKSLDWTYLQTPQYTLSTKSLVLIDADLEISVRYGAIMGGSLAVSAEGGASDRTQTLGSGWLGRRVHEIQSWESEMSTDLQGLDAWQRSRLLEWLEKMLPRPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN34</accession>
    <name>N1PN34_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_24794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN34"/>
    <dbReference type="STRING" id="675120.N1PN34"/>
    <dbReference type="HOGENOM" id="CLU_288029_0_0_1"/>
    <dbReference type="OrthoDB" id="3635319at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1068" mass="116199" checksum="66C85AA2CB07C9AA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN90</accession>
    <name>N1PN90_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_70802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN90"/>
    <dbReference type="STRING" id="675120.N1PN90"/>
    <dbReference type="eggNOG" id="ENOG502RD0D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049918_2_0_1"/>
    <dbReference type="OMA" id="ELHYSAH"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="349" mass="40330" checksum="C2B81301A7AB2C60" modified="2013-06-26" version="1">MTHQASIEQLAHVPLTPSDRPHYSRDQLQKYFERIRLPQQYCKSPVLDDPQLANTKEDGVPLLTALHRYHIANVRFENLELHYSTHRTITLNMDDLYDKFVVRGKEYGRGGRCMENNGLFGTVLRSLGYEVRNCGGRVSREWSPNADTRVKQAGTYDNWNHMLNLVRIEDQWWVVDVGMGAMGPAIIFPLQNGFESTSVAPRRIRLQKRSIPETHARSQDEAPKLWCYDQCLVPGQSGKDSWIPTYCFTETEFLPQDYEMMSWYTSTNPRSFFTYSVLCTKLLLDEDESRVVGDVTLFNDTYRKTVGGQREPAVQLKSEEERLRALETVFDVHFTEEQKMGISVEKSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNX9</accession>
    <name>N1PNX9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_71831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNX9"/>
    <dbReference type="STRING" id="675120.N1PNX9"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_4_1"/>
    <dbReference type="OMA" id="FFYPQIF"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF164">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="131"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME44139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="611" mass="67493" checksum="67CF273349ADDA39" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP37</accession>
    <name>N1PP37_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_170443</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP37"/>
    <dbReference type="STRING" id="675120.N1PP37"/>
    <dbReference type="eggNOG" id="ENOG502S9ZP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019364_0_0_1"/>
    <dbReference type="OMA" id="PAWGAKQ"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="121"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME45186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="369" mass="40276" checksum="12B9685FCC287740" modified="2013-06-26" version="1">MQPAKGIWTLIAIAIGAVKLPFWLVYYLPSATRPHPQWSYKQSILVQIIRSFLWNAAMVQMQTPLSLLPQVEKERWVVVEPAAQPSYIRVAIADPDIKPESVGGTWYPAKPSLAGKPSIVVLHFHGGAYVIGDGRTKDAGFAAKTLIANTDATHVFAPQYRLSSNKGCRFPAALQDAITTYAYLVKMEGISPNKIVLSGDSAGANLALSLTRYLTENGDQVGLDTPLATWLWSPWVSPAGSLTPEGFNSSPNVNTDYITAAFGQWGAQTFQPNSKSGITLDHPYINFAKHAFSTPVPIYISTGECEVLFHDDVKLAEDLKAVKGNVVELQIEEHAVHDTILTGKLMGFEKEAEQGAKRAGEFLRKVNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPU3</accession>
    <name>N1PPU3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_43396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPU3"/>
    <dbReference type="STRING" id="675120.N1PPU3"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_8_0_1"/>
    <dbReference type="OMA" id="LRQKSWI"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="218" mass="23546" checksum="BB1AE0D4F53200E5" modified="2013-06-26" version="1">MTFDSLNHKQYLQIALDEAAKSPPKPTNFCVGAALVSPSRNTRVLVTGYTLECPGNTHAEQSCFIKYAQSNGCNEENIGDHLPADTILYTTMEPCNKRSKGNAPCVDRILSLKRSDGSQAIKTVVVGVSEPETFVGVNEGKKKLTEAGIAVVHVPGLEDDILEVATTGHAKEDGQSQHKRTESKNDMSNDIVGMNWNLSKVSSNVSKSMWGSGATYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRF3</accession>
    <name>N1PRF3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Proteasome activator subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_70895</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PRF3"/>
    <dbReference type="eggNOG" id="KOG1851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000772_0_0_1"/>
    <dbReference type="OMA" id="ECTQLVP"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032372">
        <property type="entry name" value="Blm10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16547">
        <property type="entry name" value="BLM10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 N-terminal" evidence="12">
        <location>
            <begin position="26"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="11">
        <location>
            <begin position="392"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="13">
        <location>
            <begin position="1412"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="10">
        <location>
            <begin position="1916"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME44999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2004" mass="225416" checksum="3D0106332263CA04" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRT7</accession>
    <name>N1PRT7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate reductase [NADPH]</fullName>
            <ecNumber evidence="7">1.7.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DOTSEDRAFT_52484</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.3" evidence="7"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRT7"/>
    <dbReference type="STRING" id="675120.N1PRT7"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_4_2_1"/>
    <dbReference type="OMA" id="LRWCGVM"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="14" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="647"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="755"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="128"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EME45119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1023" mass="115438" checksum="EE448C16FBABFAD2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSM3</accession>
    <name>N1PSM3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_22056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSM3"/>
    <dbReference type="HOGENOM" id="CLU_1503401_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19980" checksum="E624DCAAF93808EC" modified="2013-06-26" version="1">MATLDSSTMSIKEELSIEEVEAAAQAKRGKLKPHVAEYLQDSLRRKVGDEKIEINSNFLIHPIAAMLAEDTGPASSSEQIATHPASRLMQKMPAELLLMEKHLEPCDVVAMALTCTYLQELYDYQLHDLRLITQKNFGSPTWKTPCFNALHTQSARLTSRLDRERTEIALEKLASGGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSZ8</accession>
    <name>N1PSZ8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DOTSEDRAFT_70151</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSZ8"/>
    <dbReference type="STRING" id="675120.N1PSZ8"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_1_1"/>
    <dbReference type="OMA" id="HWMLPAW"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1070"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1099"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="113"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="205"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="287"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EME46063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1179" mass="124469" checksum="64612383B3BD1A15" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT17</accession>
    <name>N1PT17_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GPI anchored cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_148002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT17"/>
    <dbReference type="STRING" id="675120.N1PT17"/>
    <dbReference type="eggNOG" id="ENOG502RMEY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1152208_0_0_1"/>
    <dbReference type="OMA" id="PSEYEFA"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="26215" checksum="94493D52ED9D8E6B" modified="2013-06-26" version="1">MLFLQMVSRSYKSIGDHTAQEQTTPAGLKPLTTSSQPTTVKMLAQTLSVAVLVMSVSAQSTLTESATSSLGSRTTARATTTADGEVQTTITGLIGSLTSGFAASVVNANACDTTLAMQCTGDSYACSIASDVEIMVTQNPSEYEFAYTTSTLGGQVTLSESCALKGPSGSASQLICHASYRVSAGGQQTGSSTVQTLTNSDDFNYGQIPITAGAEKLPSAGSSCTVTNQEAAATAVTGVSDVYKILVPVAAGLVGAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT81</accession>
    <name>N1PT81_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_126684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT81"/>
    <dbReference type="eggNOG" id="ENOG502RMFW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1937993_0_0_1"/>
    <dbReference type="OMA" id="LAWPKTR"/>
    <dbReference type="OrthoDB" id="3628479at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110133" evidence="2">
        <location>
            <begin position="24"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="129" mass="14314" checksum="F9D7DD59B3B10729" modified="2013-06-26" version="1">MSTYVKHIPALLLAFEHLLGGQARITDKLTPSLYRRAVINKGPGTVEALYPIIPVQDPVRHSNVVGLLMCLTGVLLAWPKTRATYAPLALNTFLTGAGVYSQRQMRIPYWLPCVNMVLGAVVWWIENDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTX0</accession>
    <name>N1PTX0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AT hook domain-containing protein family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_111981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTX0"/>
    <dbReference type="STRING" id="675120.N1PTX0"/>
    <dbReference type="eggNOG" id="ENOG502RZJF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068291_0_0_1"/>
    <dbReference type="OMA" id="DAWTYWG"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43019:SF23">
        <property type="entry name" value="PROTEASE DO-LIKE 5, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43019">
        <property type="entry name" value="SERINE ENDOPROTEASE DEGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21643" checksum="68BAE626BA52480C" modified="2013-06-26" version="1" fragment="single">ATLVFAQEAAGTAVCISRDGLILTCSHCIAEKKQDFKRNKMIWLLFSSGDPVQAKAIAWDPHRDLALLQIATAPSSLARLPYIHLALAAPKTNTRLLCVGHPGSEDFEADTSGVATDYDVLHISEGRYRGLAEGQAVQDNSEIGALMHDCWTYWGHSGAPLIERGSGGLVGLHSSWDDETGMRRGVAWEAVRDFLRAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTY2</accession>
    <name>N1PTY2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cystathionine gamma-synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">str2</name>
        <name evidence="5" type="ORF">DOTSEDRAFT_169779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTY2"/>
    <dbReference type="STRING" id="675120.N1PTY2"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_3_0_1"/>
    <dbReference type="OMA" id="HKKMHGV"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000072">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000066">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME46916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="438" mass="47828" checksum="6F0853BC371B57CA" modified="2013-06-26" version="1">MATQNGDTDPNGIEHLKIPETSSKLSLATLGVHADDAIQSYTDVAPALHVSSTFRYPRNPDDLKTESEVDVNNVFPAGGPTKGDAHIYSRLTAPNSSRLELLLSEIIGGPVLTYSSGLSAFHALLTWLHPKVVAIGKGYHGCHGVLKVYQKLTGCKIVDLFDEKSWDEAGMGEGDVVHLETPVNPNGIAYNVEDFATKAHKRGARLTIDATFAPPPLLDPWKWGADFVMHSGTKYIGGHSDMLCGVIATGKHRQGWEKDYWGMFEERIYLGSVMGSMEGWLGVRSLRTFELRVKRQSENATRLVSFLQACLDGDAKATDLEDVDGAEAVRKVLARIDHASLQKDDMGWLSKQMPNGYGPVFAITTKTAASAKRLPSKLHLFHHATSLGGVESLIEWRSMSDPSVEPTLLRVSVGVEDFEDLKADFIQGFKALAKEGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTZ3</accession>
    <name>N1PTZ3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_52255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTZ3"/>
    <dbReference type="STRING" id="675120.N1PTZ3"/>
    <dbReference type="eggNOG" id="KOG0895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_327888_0_0_1"/>
    <dbReference type="OMA" id="TGWAGQK"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="410"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="597"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="640"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="791"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="802"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME46926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="877" mass="94259" checksum="5779A9409BBEA745" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU22</accession>
    <name>N1PU22_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_70442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU22"/>
    <dbReference type="STRING" id="675120.N1PU22"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_2_1"/>
    <dbReference type="OMA" id="TCAGIQV"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF149">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="66"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME46443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="558" mass="62159" checksum="EC8A224548D6E89A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU38</accession>
    <name>N1PU38_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_78381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU38"/>
    <dbReference type="HOGENOM" id="CLU_1602677_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="166" mass="18658" checksum="8167C471BBDC1079" modified="2013-06-26" version="1">MAVFAERVLNVTSPADDEDETEQPEEEQEYSVEIEVGEDNWSAAPIGARGGERCYGPLLLICLGDQIIFLTNTTDLRACISTTQTSGACRKLQVRAGKVTASWTFDINSREFLTWSHGKTLAMDHGLRTVLRQELLSVYRVVDQPGASRVRKIPWKYVFDELFTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUJ2</accession>
    <name>N1PUJ2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUJ2"/>
    <dbReference type="STRING" id="675120.N1PUJ2"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="OMA" id="LNHHDLW"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000481">
        <property type="entry name" value="Alcohol dehydrogenase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="16"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="364" mass="38387" checksum="D295AB77CC2AA9FF" modified="2013-06-26" version="1">MPKALVIEKVEGKPGKVYYPLKLIDQPEPQPKDNELVIKITNAALNHRDLFIRQGLYGSIGFGVPMLADGCGIVVKTGASAKQWQGKRVILNPGQGWKDHPDGPESADGYAILGGTKLNPLGTASEVVCIDASEVEEAPKHLTSAEAAALPLAGLTAWRAVMTKSQAAKPGNNILVTGIGGGVAVMALLYGVAAGANVYVSSGSQEKLDKAIKLGAKGGVNYKEKDWDKKLAAALQKDTGKKKLDAIIDGAGGDIAQIGAKLLKDGGVIAQYGMTVGPKMTWVMTDVLKNIELRGSTMGSRKEFADLVAFVNEKGLKPLVSRTVHGLDNLKDIDSLFNDMHKGTQLGKLVIEIAKDEGGSKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUM9</accession>
    <name>N1PUM9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase D 3'-phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_125196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUM9"/>
    <dbReference type="eggNOG" id="ENOG502SF29">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040687_0_0_1"/>
    <dbReference type="OMA" id="SIHQRKW"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465:SF1">
        <property type="entry name" value="DNA LIGASE D 3'-PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465">
        <property type="entry name" value="DNA LIGASE D, 3'-PHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase D 3'-phosphoesterase" evidence="2">
        <location>
            <begin position="111"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="412" mass="45743" checksum="4FD4DECAD0CDC1AA" modified="2013-06-26" version="1">MARLGALYREISPPPLRKASTVAQKATEPPLTDGTARANYDEGQETSEVGRKSDLAAIEAGEIEIRDHLEYFFQHLLNASRPAVGPRTSFDAWKNLYQKSQHPHGRHFVVHQHDHPVSGVHYDLRLQVSATSSISFAVPYGLPGNPNSQRPNRMAIETRVHNLWNHLIESASHATGSLLIWDTGEYEVLPRFQKRQETTDDELSGDGVATMVTGLSQSELLHQAFQSRHIHLRLHGAKLPQDYTIALRLPASNHQAAHSKKPARKRRRQDPSKVASKTSMVVDSGSDSGTVAFPPAAIDPDAEEDDLAAAIASGDDEDATIRANNAYTGATNSIGSVHQRHWFLSLDRTYSGFHKVRGGSEAGRWIGAWEAFYVRGRDVERSVITGRNADEVMADENVEKYVGRKMWRPITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUP4</accession>
    <name>N1PUP4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_32761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUP4"/>
    <dbReference type="HOGENOM" id="CLU_1077786_0_0_1"/>
    <dbReference type="OrthoDB" id="3930519at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="258" mass="29430" checksum="36EA10A6F1655728" modified="2013-06-26" version="1">MRNGLPYRTFPIELSLGTRGKTRGIQCEQNSRRYAGVPYTLNGQTWEWTRFPLPIRLPQRSKKLSLLMSGRPRFKKGPPTDKFGALDQLCRARFKFNLVGTSTIMTEVSAMTRILLRPWASIEQGYGSYLCCDGMALKRGSWKSISLARYSPSVLVLVLVFQRLQFNSEYIWSRNRTRPPDLHQSLARVSGEESFSGELWIFQGPDLAPSDGLESLVVSVRRWRDEADATALDKLEDRTLAIVSGFTYFGICRMLDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUP9</accession>
    <name>N1PUP9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUP9"/>
    <dbReference type="HOGENOM" id="CLU_2542553_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="83" mass="9722" checksum="80B4CDCB958AA8CA" modified="2013-06-26" version="1">MAWHRRRWTSQAVHASNRSGPAWRTRMVREAVNGNSNLRETDINWHRLRILLSHCLKLIECRAPFALRRFSPSGVVEVLVSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUV2</accession>
    <name>N1PUV2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_123044</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUV2"/>
    <dbReference type="SMR" id="N1PUV2"/>
    <dbReference type="STRING" id="675120.N1PUV2"/>
    <dbReference type="eggNOG" id="KOG2937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008108_3_0_1"/>
    <dbReference type="OMA" id="PIRLCFQ"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1050:FF:000003">
        <property type="entry name" value="Decapping enzyme Dcp2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="106"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME47142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="295" mass="33520" checksum="D4CAFDC2CCAF888F" modified="2013-06-26" version="1" fragment="single">MADPALGTDVTAIQQRMTLTDWLDDLTVRFLLNLPPAELSSVPRLCFQVEEAQWYYEDFIRPLNPSLPSLNLRAFLLTLFQHCPLLSGFQTEQHVRAYEEFLEYKTRVPVRGAILMNDNMDKVLLVRGWKKGASWSFPRGKINKDEDDLDCAIREVYEETGFDATSLVDENRQKDGRVKSIDVTMKEQHMKLFIFRGVSMDTHFEPRTRKEISGIQWYNVKDLPGFKKQKGGVAGVGQGEAQTTKFYMVAPFLGQLKKWIGQQRRTEGGAAQAQHGKNLSATNNALQAGITEDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV43</accession>
    <name>N1PV43_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cellulase</fullName>
            <ecNumber evidence="3 9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_22371</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3 9"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV43"/>
    <dbReference type="STRING" id="675120.N1PV43"/>
    <dbReference type="eggNOG" id="ENOG502RXA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045022_2_0_1"/>
    <dbReference type="OMA" id="NYSPWAV"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052288">
        <property type="entry name" value="GH45_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730:SF1">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02015">
        <property type="entry name" value="Glyco_hydro_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01140">
        <property type="entry name" value="GLYCOSYL_HYDROL_F45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110202" description="Cellulase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 45 active site" evidence="11">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME46279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="222" mass="22574" checksum="8E8980DEB2B46A89" modified="2013-06-26" version="1">MHSLTTALLTALAATVASAASGRTTRYWDCCKPSCAWSGKASVTAPVTTCGKNDQPLSDANAASGCDGGSAYMCSSQSPWAVSDSLAYGFAAVSAPGGSESSTCCACYELTFTSTAIAGKKMIVQATNTGSDVSEGQFDLAMPGGGVGLFNGCTAEWGAPSGGWGAQYGGISSNTCSTFPSALQPGCSFRFDWFEGADDPTVDYQKVTCPRAITAKSGCVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV92</accession>
    <name>N1PV92_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_50721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV92"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="AKMMRKF"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF101">
        <property type="entry name" value="HIGH-AFFINITY NICOTINIC ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME47292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="497" mass="54810" checksum="B5A1BD12BE59C750" modified="2013-06-26" version="1">MAFVVDSDPAPGIDDKSKIVEDDTPVGDHNGLSIMYIDAKRERKMMWKFDLFAVGLFGLFYMMANLDRSNLGNAQIAGMPEDIGLVGNQFGTATTLLYATYVPFEAPAALLVKQLSPKYLMACCALCWGVTTLGMSFIQSWKGLYACRLLIGFFESGLIPSINVYLGMVYKKSERGKRSAVIFAFSAFSSAFGGVLAFGLTQIHGPDGFEGWRWLFIVEGALTIVLVPLFFSLFPKSPQTAWFLTGEEKVLMKQRFESDQHWGSEEHFSWKEVNKVFFDPKWYAFWVYQFCCDVSLYGLTTFLPAIVQGLGYTSVHANLMTVPIFMVSLVCFLIIAYFSDRSGVRGPFLIGALVSLVIGYAILISVENLKARYFACFLAAIGIYPTTGLSLMWLQDNVAGHYKRATMVGMTLTLGNTAGVAVGQIFVTADKPRYIKGMSIALGLACVAIAMVSSLMVGMFVVNKKRVRVVARAMQNGAVVESVPGDGDLDVHFRYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVL5</accession>
    <name>N1PVL5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_33017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVL5"/>
    <dbReference type="HOGENOM" id="CLU_1806126_0_0_1"/>
    <dbReference type="OMA" id="HYRRIRQ"/>
    <dbReference type="OrthoDB" id="2849579at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="143" mass="15934" checksum="43A6998C17762754" modified="2013-06-26" version="1">MCREILVEYTDADDDGGEAVQSVGESGPFPTQRQLSLVISEHVTPISLKIAFCQGVHSVTERDDLVDRVQGALDIIRSKIDPSSFNITSVTEYIHGLLDVNTEVDSTILLMEEAPIEHGHYRRIRQELIEVKRMIVNASEAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVV0</accession>
    <name>N1PVV0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_33128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVV0"/>
    <dbReference type="HOGENOM" id="CLU_2003860_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109636" evidence="2">
        <location>
            <begin position="17"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="124" mass="13640" checksum="397091C997581EBF" modified="2013-06-26" version="1">MLLVVVACWNITPSFAFVSGITLVQQNVAHVPYESVTARSRIAEEEEPHHSKESRSVSSCGVHLDNDEYGYESGDSALDKYAPTQLDVLEMVPDSAIESYIDDDWEENGGDHSSSFLFHAGCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX02</accession>
    <name>N1PX02_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Purine-cytosine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_149468</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX02"/>
    <dbReference type="STRING" id="675120.N1PX02"/>
    <dbReference type="eggNOG" id="ENOG502QQ8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026016_2_2_1"/>
    <dbReference type="OMA" id="LWLSANM"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11484">
        <property type="entry name" value="SLC-NCS1sbd_CobB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME46940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="58685" checksum="2BE4F3FE6151EB2D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX86</accession>
    <name>N1PX86_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX86"/>
    <dbReference type="STRING" id="675120.N1PX86"/>
    <dbReference type="eggNOG" id="ENOG502SQ3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067905_0_0_1"/>
    <dbReference type="OMA" id="WMILGGY"/>
    <dbReference type="OrthoDB" id="3254104at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="318" mass="35354" checksum="9FF7527C5958A378" modified="2013-06-26" version="1">MRPRAQSYSNIDGSRAAVKWYWTVLAVGSAFMILGGFLILPATFEKQPTHTDGNHPGSNSDIRVTPAVLGIIAIALITAAFSFTGLLCFAVGNPLFQRDLIFLPCLASCVLGLMTVVYDFLIFSRYEFKVSALLTTIAAAVSSIVYSLLLIFSLRQSGKTRTRTAPASASAQLSIPMIGIGNPQHRDSEATLWQEPTYYENYNRNMFPTAHVPREPPPSGYDPNSITEDEMQRQQMLMLLLNREQPSTPDPSQSTYRVDWQGQDDEDAPRREYYAPSSAHPSSAYPSPGITRRVTNELQPWDGVMRGVTDRMPRPTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX91</accession>
    <name>N1PX91_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_20854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX91"/>
    <dbReference type="HOGENOM" id="CLU_852646_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="326" mass="36869" checksum="545E7BDF2F526DAA" modified="2013-06-26" version="1">MHLAAVLSVNRQTDSFKICCEPLSRTLDLVRLEDCVVHSSFPADGSKLTPKWLLLNTLDEGTQDIRVIDDGIPNIVIARRDRLTLDVETIQILGDFCYNRLQPFSQWHYEHKSTRGQAVSDPAKGVALEQMSPANWAKFLAHSQEARRGQSKTTIEDTAGEVDGMAMDDGHVGDDQDALGEEKETFSDRAPRPRDAEGARRLEYEKPKPWSPTLQNRAIEWYDRLLPQISGEQMSKEVCRPLALRWIKKVSPFPWSELQKLRDEKLRAVLHKAVGERLPPELREMILEEVIKLDPACLEVVDEPGALDNLVEMAIARLMSRLSPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXG5</accession>
    <name>N1PXG5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXG5"/>
    <dbReference type="STRING" id="675120.N1PXG5"/>
    <dbReference type="eggNOG" id="ENOG502RRXM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036511_0_0_1"/>
    <dbReference type="OMA" id="MKNGWHP"/>
    <dbReference type="OrthoDB" id="3357271at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="354" mass="36890" checksum="EE14A36DDA098D3F" modified="2013-06-26" version="1">MDKVKGLAKGGWHPKGDVAIKKDTWKSDLKGMATGKKKDPYEESRNHQSAPLSSLRDPDAFGPPPKTRNTGVGGAVSGTGTASSASTGPSGGLGGPAVESGYAQRKRMEEEEVRQQAELEAERAAQARREEGYRRDTTGLSTANLPKPPVRRDAPGIGTASPALPPRVPPRQNQAPAPSLPPRQNEYPDENTPAPPPPYTEALKQTQASKLQTLPPRNLPQRDATSINQGAATRLGQAGVSVPGFGISSGGDGVNISSPRRAYDREQASGQLNELQQRFAKLNASTDERGNPITPALSAGLKTAAGKKAPPPPPPKKSSFAPGVNVGQAGASSFSESQAPTAPPLPLGSKPKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXJ5</accession>
    <name>N1PXJ5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_70012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXJ5"/>
    <dbReference type="STRING" id="675120.N1PXJ5"/>
    <dbReference type="HOGENOM" id="CLU_283997_0_0_1"/>
    <dbReference type="OMA" id="NSICEGR"/>
    <dbReference type="OrthoDB" id="10597564at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="955"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1095" mass="122723" checksum="90732EAFAD38D2B2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXM3</accession>
    <name>N1PXM3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXM3"/>
    <dbReference type="HOGENOM" id="CLU_3001959_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="57" mass="6336" checksum="D428E8E8771E7C84" modified="2013-06-26" version="1" fragment="single">RSLPSGNSTQGLGAGTVRDCDNNNNNNDIRSFRPALYLDNSSCVRHIRAVQLRTRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY70</accession>
    <name>N1PY70_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_32292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY70"/>
    <dbReference type="HOGENOM" id="CLU_1695421_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="155" mass="17854" checksum="6302555CCE50F6CC" modified="2013-06-26" version="1">MSRNSSAPDHREILQTSSSQSCFPAQRFHTLLDYPAILLSALVHCNDARMVFNDYLDTAEVEEVEGIVRGDVRNLNFFLIETRRTTTHSNTMPSTSPATTTRCYILELSAELRLIIWGYYLSSTDLPRWRNARHNKKAGPIEDRMPYRLPVCYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYC2</accession>
    <name>N1PYC2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_39859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYC2"/>
    <dbReference type="STRING" id="675120.N1PYC2"/>
    <dbReference type="eggNOG" id="KOG3383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_762960_0_0_1"/>
    <dbReference type="OrthoDB" id="41445at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="4">
        <location>
            <begin position="28"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME48521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="363" mass="39372" checksum="0BDEC489B2C75157" modified="2013-06-26" version="1">MKVMIVLPTANDDDDTEQDREQTSSGINYWLMKAEQDGHDVTVEGGTTVNTTFTIDDLRAKAEPEPWDGVRNPKAAMNMRNMRVGDMAFFYASGGKQGRKPGITGIMEIVSKAEPDATVNDPRSAGYVVKEADRKKWVAVRVEFRKKLSKPVHLTELQQYKNAELKDLQEFTAARLSVSKVSEKEWTFIYNLIEGFDDVGKAGDLDGELEAQVAGPSGAILLTEDTTFIVTEQPNGDVVAEGQTDDIVEKELDLPKGYAPPAIMQTTEPELPTTDTIFPDATSATERSASRTGSHRSSRAPSATRLGVNSSRPGSRARSLAPPTARGRSRTPGARGGSVGPPLPGMNEDLTGFLDSVAEVNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYX1</accession>
    <name>N1PYX1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">tub3</name>
        <name evidence="18" type="ORF">DOTSEDRAFT_69388</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYX1"/>
    <dbReference type="STRING" id="675120.N1PYX1"/>
    <dbReference type="eggNOG" id="KOG1376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_1_1_1"/>
    <dbReference type="OMA" id="YMASCIL"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME47444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="450" mass="50108" checksum="48E75627403F0562" modified="2013-06-26" version="1">MREVISLNVGQAGCQIANSCWELYCLEHGIQPDGYLTEERKATDDDHGFSTFFSETGNGKYVPRTIYCDLEPNVVDEVRTGAYRSLFHPEQMITGKEDASNNYARGHYTVGKELIDQVLDKVRHVADNCSGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKCKLEFCVYPAPQVATSVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLGIERPNYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYAPIVSAAKAAHEANSVQEISMSCFEPNSQMVKCDPRNGKYMATCLLYRGDVVPKDVHQAVATLKTKRTIQFVDWCPTGFKIGICYQPPQMVPNGDLAKVNRAVCMLSNTTAIAEAWSALSHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVAADSAEGEEGAEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZ65</accession>
    <name>N1PZ65_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PBP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_166659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZ65"/>
    <dbReference type="STRING" id="675120.N1PZ65"/>
    <dbReference type="eggNOG" id="ENOG502S5YI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058099_0_0_1"/>
    <dbReference type="OMA" id="SATMWKE"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052738">
        <property type="entry name" value="ABC-Tungstate_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945:SF1">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP" evidence="1">
        <location>
            <begin position="65"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="335" mass="36836" checksum="71BDDEC333D1FEE9" modified="2013-06-26" version="1">MAAAANESGLLDTSNLPPRVSVTDPWVSRYHKTCLLEQDHGPAGSRLFSTVDREVYGERAHPVSFRIGNGGAGFTGLLRMLCETYIREHGNNFRIAWVANHSRYSQLALLADVVQLALTYEPENENLAIEEGWAVRACRAFNDHFVLVGPESELEGRTVAEGLRSIARRNAVGAADQHRSHQLIFHTRGDGSATYCKEQALWKTAGGVDQDSTWIKTHAASPYEALLCAEAEGAYLLSDRATFLTAKEDGVIPSLKVHIEGGPELLNPCAALVRGDAAKKWCQENSAAAKFAAWLHQGRAQEIIHNHGRDWKIGKPLFTIAAQEEFAEEDRLVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZB3</accession>
    <name>N1PZB3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_19276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZB3"/>
    <dbReference type="HOGENOM" id="CLU_1042152_0_0_1"/>
    <dbReference type="OMA" id="HECVEHE"/>
    <dbReference type="OrthoDB" id="10506485at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="267" mass="30873" checksum="2D354413885D3A12" modified="2013-06-26" version="1">MASSLPPGWAAMPPPEPKDLILHINDTFHRFLDDYHECVEHEVGYAFIVDGGRQCLLLAVLNEDQYPDEAVQPGQSVALRDEDGDSGLRYEIIGAIEHTEIIMFCDDQRLKTFFSKTGRKFLKDVRVQDLVYERMVEEMFENLKVVQADAKQARREKKERQKEAREASTAASTITSTTDQFSIDFEAADRKREKRRRKAQNQKTHRAKRAEELRKQQRDQRKNMREIQKTLEEDGMEGEFVDPSSGEGQKRIQEAMAKGARIYTVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZI7</accession>
    <name>N1PZI7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_67791</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with the respiratory chain complex III/complex IV supercomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RCF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZI7"/>
    <dbReference type="STRING" id="675120.N1PZI7"/>
    <dbReference type="eggNOG" id="KOG4431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087356_0_2_1"/>
    <dbReference type="OMA" id="YYRTERT"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="11">
        <location>
            <begin position="12"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="146"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME48847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="203" mass="23930" checksum="75AFB15B6F50E86B" modified="2013-06-26" version="1">MSVPGNINTAPPPSSFDEDNEFYEESRWGKLRRRIKEEPLIPLGCALTCWALFEATRSIKSGDKYRTNRMFRRRIYAQGFTILAMLAGSAYWEGDRGKRKEYDVLVEEKKKKDKHEAWLRELEVRDQEEQELRAIRDRLMKGRVAEKQQYSESEKRTLENRQKKQAGQDKGGFGEVRSALEESERRRSVKVLETVADLLERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q020</accession>
    <name>N1Q020_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_19116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q020"/>
    <dbReference type="HOGENOM" id="CLU_1845031_0_0_1"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="139" mass="15968" checksum="5DEAEB70A57067BF" modified="2013-06-26" version="1">MKLVFVIDPVLYPEEFHPVRVVHAFHLGSAAKALHTMKHSICRRLERLDIDPDILFDGLVVRLDEVIVKSHGRDSQLGAPIGRNMDFLRSSRDPITRIFGWTEEQWAFNMSVKVADNWLKVEKVAKWITVEQSGLTFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q077</accession>
    <name>N1Q077_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q077"/>
    <dbReference type="HOGENOM" id="CLU_2196893_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="108" mass="12514" checksum="B769A656F602287E" modified="2013-06-26" version="1">MLHSKRISWVASRRRKGVKHILDLRERTMSQCPSILEGGRLLNGLLRSRCLRAERTSCRGPRQLRMRKRCLLFRRAGRANKLRTDGSKEVDLERVSGRGCRSTLPTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0Q5</accession>
    <name>N1Q0Q5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_76690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0Q5"/>
    <dbReference type="eggNOG" id="ENOG502SJAV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1768001_0_0_1"/>
    <dbReference type="OrthoDB" id="4738875at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME49356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="147" mass="16392" checksum="484B955E3A096FD7" modified="2013-06-26" version="1">MSTALTIRGFCPINMRVTVSPSDDAGTDRLLEITSLALQRNEPVWDVMYLYQLTEEGRKHGTERLRDLNITGPSVTFLKAVDDKTNDIAMHRGKGVAQALVRWGSEQADALRLNAVVESRYILMHVAGFPQIIKPFAARVPRAAQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0V9</accession>
    <name>N1Q0V9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_69881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0V9"/>
    <dbReference type="STRING" id="675120.N1Q0V9"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OMA" id="EMMKMWT"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF6">
        <property type="entry name" value="AMIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="76"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="228"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME48089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="587" mass="64440" checksum="8C7CA7AA65F17B33" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q112</accession>
    <name>N1Q112_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_163851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q112"/>
    <dbReference type="STRING" id="675120.N1Q112"/>
    <dbReference type="eggNOG" id="KOG1354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021713_3_3_1"/>
    <dbReference type="OMA" id="NQIKWCR"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000705">
        <property type="term" value="P:achiasmate meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071475">
        <property type="term" value="P:cellular hyperosmotic salinity response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905477">
        <property type="term" value="P:positive regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061586">
        <property type="term" value="P:positive regulation of transcription by transcription factor localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME49456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="482" mass="54290" checksum="F32765752C1F92C0" modified="2013-06-26" version="1">MVEAGEGAPQPTWKFTQCFGDKGDVEDITEADIISTVEFDQTGNYLATGDKGGRVVLFERNETKKTCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNASHYLLSTNDKTIKLWKVFEKSLKVVAENNLSSELTPAGTGGANGGGPVRYPNQHFRSVADLKFPRMTHHDTVVAAVPRRVYANAHAYHINSISVNSDGETFISSDDLRINLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPASCNQFIYASSKGTIKLADMRQKALCDEHAKQFEQEEDPSSRSFFSEIISSISDVRFSFDGRYILSRDYLTVKIWDVNMERQPVKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDAKNVMTGSYNNNFMIYPSEEGKDTEVVLQADKSAFKAKKVGIPTPMNSATSPGAGKDGKKGSRANSPAGGAQRMRKETDADQIDFNKKILHMSWHPQEDSIAIAATNNLFVFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2U4</accession>
    <name>N1Q2U4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_40747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2U4"/>
    <dbReference type="STRING" id="675120.N1Q2U4"/>
    <dbReference type="eggNOG" id="KOG1255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2799">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015460_0_0_1"/>
    <dbReference type="OMA" id="HTRVIFQ"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000017">
        <property type="entry name" value="Succinyl-CoA synthetase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000340">
        <property type="entry name" value="Succinyl-CoA synthetase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF6">
        <property type="entry name" value="SYNTHETASE SUBUNIT ALPHA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="2">
        <location>
            <begin position="46"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="707" mass="76062" checksum="F50B3B1F4E0B5F04" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3I4</accession>
    <name>N1Q3I4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_20713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3I4"/>
    <dbReference type="HOGENOM" id="CLU_2003852_0_0_1"/>
    <dbReference type="OrthoDB" id="3647705at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME50351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14219" checksum="3D3CD799F906819F" modified="2013-06-26" version="1">MKDQKMAHFSHLPPELRNQIYFYLITPSPSMESNDIVCSADDANEELDDGIYSPARPPIEAIAKLAQVNRQIRSDFLLIYHHHCKLSLCFDHSLTSCSSWLRVFGASRVHPHRRVRISIGRISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4D4</accession>
    <name>N1Q4D4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OsmC-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4D4"/>
    <dbReference type="eggNOG" id="ENOG502S77G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106355_2_1_1"/>
    <dbReference type="OMA" id="SACFSNA"/>
    <dbReference type="OrthoDB" id="60422at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797:SF2">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18052" checksum="0FD194FD41A3A8F0" modified="2013-06-26" version="1">MASIRTLRPALSSAPRLISINIPTKRFLNWSSSPPLTTAHATVTGGRQGHATTSHFELDLGMPKDLGGDGKKTNPEELFAAGYGACFQGAMAATAPSLGMKAPETTLVADVHLIGDAKKLDMGIRVDMKITGKGISAEDLKKLVEKTKTVCPYSRAVEGNVITNFEVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4D6</accession>
    <name>N1Q4D6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4D6"/>
    <dbReference type="STRING" id="675120.N1Q4D6"/>
    <dbReference type="eggNOG" id="ENOG502T2EZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422094_0_0_1"/>
    <dbReference type="OMA" id="YWRESFQ"/>
    <dbReference type="OrthoDB" id="5428925at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="676" mass="73953" checksum="5A218ACEA63CE4AC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4H3</accession>
    <name>N1Q4H3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4H3"/>
    <dbReference type="STRING" id="675120.N1Q4H3"/>
    <dbReference type="eggNOG" id="ENOG502SDRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_325409_0_0_1"/>
    <dbReference type="OMA" id="LNVMEGN"/>
    <dbReference type="OrthoDB" id="3438840at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="886" mass="96752" checksum="A275AF3A8B7EEEE3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4S7</accession>
    <name>N1Q4S7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_68605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4S7"/>
    <dbReference type="STRING" id="675120.N1Q4S7"/>
    <dbReference type="eggNOG" id="KOG1583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033007_1_1_1"/>
    <dbReference type="OMA" id="NPFTGWH"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015786">
        <property type="term" value="P:UDP-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME49865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="39964" checksum="E5F98A1B7A2B8386" modified="2013-06-26" version="1">MVGFDTLATTGLIFGGCCTNVFALEGIVKLESRSGLVITFFQFAFTSCFAYLTQFNYGAAYTVRKPKVPLSRWTVIAAMFFAINMLNNWAFAYNISVPVHIILRSFGSVTTMCAGVLRGKRYSRLQVLSVVLLTVGVLTSAWADSESKGKKMSVENEASSSDFIQGLGILLLAQFMSAYAGAYTEDTYAEYKAKWTENLFYSHILGLPLFLPLASTLRNQYRKLADTPHVSVRQYLPSILAQTGTTSEATGRLAPCPYPETMPKGILLLFTNAVTQLACISGVNLLSAKSSAVTVTIVLNIRKLVSFIMSTLLFGHQLNTKMILGATLVFGSGALYGYETSWRIPTQKKQTRAVASGRPAEKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4V4</accession>
    <name>N1Q4V4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4V4"/>
    <dbReference type="HOGENOM" id="CLU_2671028_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="75" mass="8336" checksum="D835F2614AF48702" modified="2013-06-26" version="1">MSISLTSQARTSTSTSILSTEYAVPSSATARPRPDLGVYDFCSKSNHHTHEPLVHAPRRTCNHIVRDAICRNNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q574</accession>
    <name>N1Q574_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_85305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q574"/>
    <dbReference type="STRING" id="675120.N1Q574"/>
    <dbReference type="MEROPS" id="S12.012"/>
    <dbReference type="eggNOG" id="ENOG502S3SB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019706_1_0_1"/>
    <dbReference type="OMA" id="WEIFRTD"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109903" evidence="2">
        <location>
            <begin position="21"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="95"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="4">
        <location>
            <begin position="418"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME50059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="579" mass="64525" checksum="50620F8FBD793A21" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5F4</accession>
    <name>N1Q5F4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_20619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5F4"/>
    <dbReference type="STRING" id="675120.N1Q5F4"/>
    <dbReference type="eggNOG" id="ENOG502S9SN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032998_0_0_1"/>
    <dbReference type="OMA" id="MSWRNPL"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="257"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME50249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35363" checksum="2AB9EC8BC269D52B" modified="2013-06-26" version="1">MSWTSRLGNLGRFSPFTRSPPQGSTKVSDADFSYITADDLRKHQAETMNQQQQSGDSAPDLGPPRDTDVIRLRNKRQEYAVHFPAYSIAKGELTIGQVRDQAAKKTGTADTRRIKLLYKGRNLKDGSRTCKQEGLREGAELMCTIAEKLDSPSSSDDDDDDEFAYDAGTAGGEPKRRRNRGKKSKRRNKREEREGVSGTSTPQPGEPNLGVPNSQQHPRAQSPKPPTSPATPLDKLNELHQKLQTFIPDVRAFQTAPPSDPAKKEFEHKRLSETILTQVLLKLDAVETEGDSDARTRRKALVQETQKVLADLDIAMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2WHM8</accession>
    <name>M2WHM8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_29698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WHM8"/>
    <dbReference type="HOGENOM" id="CLU_1517819_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="177" mass="19473" checksum="FB91415E88AD9969" modified="2013-05-01" version="1">MFSDEFTELSYKPAAAPLRPKPFERRWNYCIFCQRWGSGRSKDWDLIDSPAPSAAQQQIVAQVDQEITAAAALSRGINYLTNMVNSPILLRAPGRAYVSAGRPQAPAMIPGSIIPRSSRKVRVRTGGSIDGEDEVEYQDKDKSDGYEDEDDETSDTPAASLTATTHQGPLAPARRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2WI04</accession>
    <name>M2WI04_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_38896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WI04"/>
    <dbReference type="HOGENOM" id="CLU_1917021_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004028558" evidence="1">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="132" mass="14151" checksum="BED8652BC3DC20EF" modified="2013-05-01" version="1">MKFQLLTTLLACFVATTIAIPDLAQIKHPDGKKALNWPPADQSVSRMSNKGVTLCSAKLTAHPSRSFSGAVIDLVPRFRTMGRTSREGNGHYRRLSGVSVVAMGILSVVYSISDEILVVACILAVSRHAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJB9</accession>
    <name>M2WJB9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cup1</name>
        <name evidence="2" type="ORF">DOTSEDRAFT_29250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJB9"/>
    <dbReference type="eggNOG" id="ENOG502S90D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096188_1_0_1"/>
    <dbReference type="OMA" id="HLIVCEL"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="84"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="178" mass="19348" checksum="A56258BBACA9E6FC" modified="2013-05-01" version="1">MSSYITTHNSKGEAIFSDKVTNSPPKLAFVPGRQDLGYQQIIYDSDILRPDLSHEGDIDTYAERRHKGYPQGQIGPANGPNFGLVTMCAGGSSPFHRTMTLDAIYVTEGEVELHLDSGEMKVVKAGDSVVQRGTMHKWVNVTPNGGQMKMVTMAQPIANGGPIVVGGEKLETEWKARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJP1</accession>
    <name>M2WJP1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_56653</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJP1"/>
    <dbReference type="STRING" id="675120.M2WJP1"/>
    <dbReference type="eggNOG" id="KOG2586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_670892_0_0_1"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="9">
        <location>
            <begin position="81"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="10">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME39183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="410" mass="46851" checksum="D774D8B9A54650ED" modified="2013-05-01" version="1" fragment="single">MLCRKRAVNLSLQHNFILHSPRRHFSFTPFRFDSSMSSGKKIFAPGGTNDSLQAEQYTKGSLTINQLDKDPFTQFDIWFKHANQEKVYQPETVTLSTAELPTGRVSARMVYLKEMDDKGFVIYSNWGTSRKASDVASNPHAALTFWWHELERQVRVEGPCERLTGEESQVYYDTRIRGSRLGAWASQQSKVLQSREELEEQVKDVEKRFDGREEIPVPEFWGGLRVRPEMVEFWQGRPSPISPDEAQHSIVAVIEQSWSQRPTTELSNPAKQLSRLLRNTLEADYTNGSKQSYSLCFSWDVKYVEAVQGTQIRFIKVAGLLLQYSSSARRMWDYELIEDYVKAGHTPDVVVKMYRAAYQVVPVVATSNKDAASLLGSIVTVARKYAHQPLMLTERISAIEEKAAWYGGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2WKW8</accession>
    <name>M2WKW8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_160022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WKW8"/>
    <dbReference type="STRING" id="675120.M2WKW8"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_8_1"/>
    <dbReference type="OMA" id="FPLEKHM"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME39628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="360" mass="40059" checksum="501B738795F6921C" modified="2013-05-01" version="1">MALEGEKDILVTGGSGYLGRGIVKALLHRYPSWRITVLDLQQPDADIHGRIASFIEADITSEKAVREAFANLRPDLVVHTAGIVPARTQRYSTNRRQWEKVKAINYDGTRHVVDAVLAAECRKLVYTSSCTVVVDDLKHDYFHMDETTPLGLAHLHYGKSKGLAEQYVLSVEHQERGLKACALRPCTIIGPGDTAVISIFYDCIAKGETNFIVGDGNNIYDFMYIDNAVDAHVLAIENLLTTQTAAGEAMFISNQEPIYFWDFLAFVWAQFGHVPALRIYIPMQIAWFVALILEWITLLTGTASTLDTGSVADGVRTQYSNNAKAQRLLGYYPKVGISEGVRRACEDYKQHLAKNKATKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2XGY3</accession>
    <name>M2XGY3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_180608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XGY3"/>
    <dbReference type="HOGENOM" id="CLU_786556_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="353" mass="39136" checksum="BF2128F1AEBC6E16" modified="2013-05-01" version="1" fragment="single">MLDTELNDEEHSVSLDRLDAVASLYEHGTVSPTVKDNAASALLRWLTETCDLLVSEQHDRLHAIRGICGNLSISLPRPDYALPVDELWKRISSLRLTSIPYWTIDTQGMPDPACLMLLAGLQKLESGTGDVSWVLDMSRLSGKIYSKYRFLAATTSAVIMPMSSLFLPERLNAQELGCHGQVLCDISSVACRSAWPSPERKPENHGHMWVKLDLLPWLNCCQTFAVDHEWDDGQAQDLHLMELLAPRNSPGEWDVDHQQLANLSRSSTSAEGKSVLDEGTDGSLYVSSTSRLFDFHRTNKGVQLAVTLDSQFCWIPSHASVGDRLCVLYGAPFVLCSGRVERIAIVSLAMHTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2XJL2</accession>
    <name>M2XJL2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_28772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XJL2"/>
    <dbReference type="STRING" id="675120.M2XJL2"/>
    <dbReference type="eggNOG" id="KOG3010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_4_0_1"/>
    <dbReference type="OMA" id="WRATFDT"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="61"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="320" mass="35510" checksum="D6E3CC2C8A7F9DC0" modified="2013-05-01" version="1">MATQQSTPAAPAAAGGINARAQSGFAKSSAYDAHRPTYSSSIVQLLLEKIEVSGNKLARIVDLAAGTGKFTEALAARDEEFEIIAVEPHLDMRNVLSSKKLPRVKVVEGTGERMEGVESGSVDAVVVAQGFHWFSNMTALKEIHRVMARHSALGLVWNVEDYNNARNHKASTAWEARLHDLTWKISEEVGDVEPRFRHMQWRKVFDEQVKKTPLSLLIASDDQLFSLPIAEEQEPFEVTLSVESLWNRYSTLGHIAALEKEHRERVHKTFMEIVSAPEVEKNEAGEVAVHGNTYAVWTTKIPAEGRTGSQTLDDVERAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKJ6</accession>
    <name>M2XKJ6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HPP transmembrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_173598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKJ6"/>
    <dbReference type="STRING" id="675120.M2XKJ6"/>
    <dbReference type="eggNOG" id="ENOG502S3SU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040397_0_1_1"/>
    <dbReference type="OMA" id="LCFNASQ"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="3">
        <location>
            <begin position="55"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME43017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="333" mass="37125" checksum="0B2DE7C371D4060A" modified="2013-05-01" version="1">MALPNDPKPLYQLLDFDIDRYINPWIPHNRLHYLPTAVSRWLGYRPAPVKEPYAIFQWPVTFLATVASLCLLGGLGSYAPGLVGWHPPVIVASLGASAVLDFNAIKSPLAQPRNAILGNTLAAICGVAVAKGFEHYSSFDQAYPHNIQWVAGAVGCALASLVMSLTNTIHPPGGATAVLASTQTQIIAMGWRFVPIILLDSTLMMVVALIFNNVLRQYPMYWWTASDTGSKLRQQRREARGETETQVDEDHMEKGKARSDSDASSDTDRTLRRELSNPLASVEFVDGMEDVHITPYKIQMPHHLKLEDDEVLFIERIQERLRMHGEIDPRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKQ2</accession>
    <name>M2XKQ2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_89047</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKQ2"/>
    <dbReference type="STRING" id="675120.M2XKQ2"/>
    <dbReference type="eggNOG" id="KOG2713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_1_3_1"/>
    <dbReference type="OMA" id="PNHIRIE"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME43087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="359" mass="39176" checksum="32A5EB2EF908E544" modified="2013-05-01" version="1">MRLSPEARGQPLPPKKIIFSGIQPTGIPHLGNYLGALRQWVRLQSEADKSTRLIYSLVDLHAITIRQDPAQLRQCKKESLAMLLAIGLDPVRSIIFHQSDVPAHAELMWILSCQASTGYLGRMTQWKDKTSNEKEGSERLKLGLFSYPVLQAADVLVHQTTHVPVGHDQAQHLELARELAHGFNHLYGDGVLTAPETLIGPAKRVMSLTDPGSKMSKSHPNVKSRVLLTDGEDVIKAKLKAAVTDSMDGITYDPQNRPGVSNLLDIIYHATSIEASPGDAADGAGQVALAKDMEGMSLRIVKERATEAVENMVKPIRERYAELIHDDAWLTEAAAAGAFKAQISAAETIQKVKKVVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2XL53</accession>
    <name>M2XL53_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_72569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XL53"/>
    <dbReference type="STRING" id="675120.M2XL53"/>
    <dbReference type="eggNOG" id="KOG3742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015910_1_0_1"/>
    <dbReference type="OMA" id="RDVRNHI"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="607"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="669"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME43222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="723" mass="81939" checksum="EB1C727AB9BA6A1B" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y2T0</accession>
    <name>M2Y2T0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_28728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y2T0"/>
    <dbReference type="HOGENOM" id="CLU_1189895_0_0_1"/>
    <dbReference type="OMA" id="RSEWEEW"/>
    <dbReference type="OrthoDB" id="10486794at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="233" mass="26787" checksum="2B991FB72DC04C03" modified="2013-05-01" version="1">MVANQPTTYKARRFAGRFSSTRSTALMFKAHRFLDEDPNADQIQVLYCMPGPSDTFTVRYISRSALLDPRYWLSSPVSSLLGYPLKLCITDMNDILQPAYSIQEADEPLCHVANRFMTICDVRSDQFGEIYGFGALRGMAVFVCEDGTVPDLGYSSCANAYVKKWVILVGNEVERLRKRGNEEGLRRYREEVRDVFGDGAMRSEWEEWQRRETEQREKFERDRMAAEAAEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y2X3</accession>
    <name>M2Y2X3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_83306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y2X3"/>
    <dbReference type="STRING" id="675120.M2Y2X3"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="OMA" id="YCLQKNW"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="44"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME39639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="291" mass="32165" checksum="6A584E1C2D365B18" modified="2013-05-01" version="1">MSSRRMAKSLSLKTTLKLRSGAELPQLGFGVWDSPSHLTTKSCLEALKVGYRHIDTAQVYGNEAEVGEAIKKADIPRKDLFITSKVLAAEGDEEVTYQKCLESVKKIDGDNGYLDLLLIHNGQTQGARGIKALWPVMEKLHQEGKLKSIGVSNTGVGLIESMKGYAKVWPPHVNQLELHPWCQQREVVEYCHKNGIAVEAYCPLVRNKKAADKTLKSIAERHGKSTAQVLLRYCLQKAWAPLPKSDNPERIAQNANIYDFALSDEDVQSLDGVGEKEAEALVVAVDNKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y318</accession>
    <name>M2Y318_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y318"/>
    <dbReference type="HOGENOM" id="CLU_2512606_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="85" mass="9108" checksum="74E7F74FB8272971" modified="2013-05-01" version="1">MLPEMHSNRAKGLMSASNLPWVQRAMPVTHRSGLRTGRSNSNRTLKEPPQSGVCGVTGCVALSAFTRSMLLLVNGSFATFDATTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y4F1</accession>
    <name>M2Y4F1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_54065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y4F1"/>
    <dbReference type="HOGENOM" id="CLU_849987_0_0_1"/>
    <dbReference type="OMA" id="CLMAGNC"/>
    <dbReference type="OrthoDB" id="10438110at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004029931" evidence="1">
        <location>
            <begin position="20"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="327" mass="34799" checksum="CCEE65532B6A6DBF" modified="2013-05-01" version="1">MTKITEFLALAAVTAGAYGVTDSCKDLECAATADTTQEVQTLFASPLIARGNKVSCHVGHGWNEDVQGELEHFISDFDTTYEGKFLAHGTECAEWYTASNGAKFYLSINNRACDSVKVEQAVDAISLAVHNCRIEGSDQYSGGAVDYNISPDAPSGCGQYVIFYSSSDMTAAISRPSKRATNVCSTCPQFCLNSFSTCNPPVWSGCTQPEKDCILSEADSFYSCLIAGNCARYQAKVKRRSGPCSRCSKVCLLQDTTCNPPVWTTCTPTEKECLLDFASDYMGCLMAGNCFPGGGTDVTVTPPSDGTVVSVQPPSGTYVTVSGPPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y4S3</accession>
    <name>M2Y4S3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ERG20 farnesyl diphosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_72634</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y4S3"/>
    <dbReference type="STRING" id="675120.M2Y4S3"/>
    <dbReference type="eggNOG" id="KOG0711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028376_1_0_1"/>
    <dbReference type="OMA" id="CSWVVNQ"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME43289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="40220" checksum="C6081551A0DD0539" modified="2013-05-01" version="1">MPATLKDFETVFPKLVEDLKEHCEKYKLPQQALTWFERSLNHNTLGGKCNRGLSVIDTTQLLLGRKLSNDEFFKTATLGWMIELLQAFFLVSDDIMDSSKTRRGHPCWYLMPNVGMVAINDAFMLESSIYVLLRKYFRQERYYIDLVELFHEVSFQTELGQACDLLTAPEDHVDLDNFSLEKYTFIVIYKTAYYSFYLPVALAMHFAGLATERNLKQAEDILIPMGEYFQVQDDYLDNFADPSVLGKIGTDIQDNKCSWLVNQALKIATPEQRQVLEKNYGQKSAQCEAEVKKLFNELQLQKVYQEYEEQRVGELRERIAQVDESGGMKKEVFEEFLRKIYKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2YHP2</accession>
    <name>M2YHP2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_141292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446552">
        <property type="protein sequence ID" value="EME38020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YHP2"/>
    <dbReference type="eggNOG" id="ENOG502S1X0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178970_0_0_1"/>
    <dbReference type="OMA" id="SFFPWPE"/>
    <dbReference type="OrthoDB" id="1733326at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33626:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33626">
        <property type="entry name" value="ZGC:158463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="109" mass="12092" checksum="CD419B0D85C21895" modified="2013-05-01" version="1" fragment="single">GNNRSVMPLDVLGRTRATLTEPTSSSPWPEGLGNLVKLCRAGDRALQLLLFNEECLVSACHQHALITSLPFVHTARRYYRLNGSVRPSDWPREVGNDHPGPESWSNSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2YHT9</accession>
    <name>M2YHT9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_39607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YHT9"/>
    <dbReference type="HOGENOM" id="CLU_906210_0_0_1"/>
    <dbReference type="OrthoDB" id="10450373at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="307" mass="33871" checksum="F6401D37CF4917A4" modified="2013-05-01" version="1">MTQVRPKAQNQALAFASPPASLHTDNCVPFLESRPDTSKKDLSPDSVTPTPPQRIESDSRNNPAMLQANATALSAANKAAAEVFCTSELLENVLAHLDDIKTVVKLSTPARQHTTSSTRSAQRLTGRTEVVLPSKKVIQHLRQCNACKIEQFLATSLAKLFVCQPPTETVLMDSCERHPTGEGYSKSGVRSVRATPGVTLGDVVQAIFSPERRGPKVHDLRIPGALSITQHEWAVMREKRILHRTPIPKSATGRTLIHPSRTWISLRLSGVGDQGVRLPAYTTHSHRAFHHQDYKRRRPDCVSACHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2YI65</accession>
    <name>M2YI65_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_48170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YI65"/>
    <dbReference type="HOGENOM" id="CLU_2497871_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="86" mass="9425" checksum="3CB0DF51CE94FB65" modified="2013-05-01" version="1">MRISQIPGNLRAEHMDQVAFTRMRSRLRSRKERDHVLSKKKGVSIALPGPETALQACNDGETAPLMLQQGIEGSCIARKPVAGKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIM6</accession>
    <name>M2YIM6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_139742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIM6"/>
    <dbReference type="STRING" id="675120.M2YIM6"/>
    <dbReference type="eggNOG" id="ENOG502R9HF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_831624_0_0_1"/>
    <dbReference type="OrthoDB" id="3944128at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="334" mass="32800" checksum="C842A13229A94D88" modified="2013-05-01" version="1">MWYNGLWDPPLALRPASSEVVPTAPGGGGGEVQATTTVHAVPSSQPQSPTVPATAASIVAPTTPVAESSGPHKGLPEATPKPKPTGYVPANEPWHQNVNIGGKNYAATAANGVCRVAGVTLTVGAPAQTLPDGVVCSYGQNGLVVQGSKTIHFNDNADQAQSGSQPLTTIGAQNGDFDAQNGHSGNNEGNEDAAVITINDHAVTAVQTQEGGLIIIGSSITLTLGGAATTISGQVVSAATNGVVLGDVSTVGLNEGSATTGSQGGMPSNTAGSGNDNDDSHTSISSNSLSGSGTNSTTATATGNLPVATGFASSMSPAQALSLFTALLAVIAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJH5</accession>
    <name>M2YJH5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_29245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJH5"/>
    <dbReference type="HOGENOM" id="CLU_2196888_0_0_1"/>
    <dbReference type="OrthoDB" id="5380902at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="108" mass="11882" checksum="3FD59501E70FCBA6" modified="2013-05-01" version="1">MAEAITMLGAASSILQTVDFPCKLISHTRELNSANNDALSENIEIERLVRSLSKAGTNLAHAIPDASKRTTEQQDSTQITCLRRLDAKELLNKLQDQEAMLLTMAGRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-02-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJJ3</accession>
    <name>HEXA_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acid synthase alpha subunit hexA</fullName>
            <ecNumber evidence="1">2.3.1.86</ecNumber>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
                <ecNumber evidence="1">1.1.1.100</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">Beta-ketoacyl reductase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
                <ecNumber evidence="1">2.3.1.41</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">Dothistromin biosynthesis protein hexA</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">hexA</name>
        <name type="ORF">DOTSEDRAFT_66976</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Appl. Environ. Microbiol." volume="68" first="2885" last="2892">
            <title>Dothistroma pini, a forest pathogen, contains homologs of aflatoxin biosynthetic pathway genes.</title>
            <authorList>
                <person name="Bradshaw R.E."/>
                <person name="Bhatnagar D."/>
                <person name="Ganley R.J."/>
                <person name="Gillman C.J."/>
                <person name="Monahan B.J."/>
                <person name="Seconi J.M."/>
            </authorList>
            <dbReference type="PubMed" id="12039746"/>
            <dbReference type="DOI" id="10.1128/AEM.68.6.2885-2892.2002"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Mycopathologia" volume="161" first="283" last="294">
            <title>A polyketide synthase gene required for biosynthesis of the aflatoxin-like toxin, dothistromin.</title>
            <authorList>
                <person name="Bradshaw R.E."/>
                <person name="Jin H."/>
                <person name="Morgan B.S."/>
                <person name="Schwelm A."/>
                <person name="Teddy O.R."/>
                <person name="Young C.A."/>
                <person name="Zhang S."/>
            </authorList>
            <dbReference type="PubMed" id="16649078"/>
            <dbReference type="DOI" id="10.1007/s11046-006-0240-5"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Fungal Genet. Biol." volume="44" first="1342" last="1354">
            <title>A fragmented aflatoxin-like gene cluster in the forest pathogen Dothistroma septosporum.</title>
            <authorList>
                <person name="Zhang S."/>
                <person name="Schwelm A."/>
                <person name="Jin H."/>
                <person name="Collins L.J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="17683963"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2007.06.005"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2010" name="Toxins" volume="2" first="2680" last="2698">
            <title>Genetics of dothistromin biosynthesis of Dothistroma septosporum: an update.</title>
            <authorList>
                <person name="Schwelm A."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="22069571"/>
            <dbReference type="DOI" id="10.3390/toxins2112680"/>
        </citation>
        <scope>REVIEW ON FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2013" name="Fungal Genet. Biol." volume="51" first="12" last="20">
            <title>Dothistromin genes at multiple separate loci are regulated by AflR.</title>
            <authorList>
                <person name="Chettri P."/>
                <person name="Ehrlich K.C."/>
                <person name="Cary J.W."/>
                <person name="Collemare J."/>
                <person name="Cox M.P."/>
                <person name="Griffiths S.A."/>
                <person name="Olson M.A."/>
                <person name="de Wit P.J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23207690"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2012.11.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2013" name="New Phytol." volume="198" first="525" last="535">
            <title>Fragmentation of an aflatoxin-like gene cluster in a forest pathogen.</title>
            <authorList>
                <person name="Bradshaw R.E."/>
                <person name="Slot J.C."/>
                <person name="Moore G.G."/>
                <person name="Chettri P."/>
                <person name="de Wit P.J."/>
                <person name="Ehrlich K.C."/>
                <person name="Ganley A.R."/>
                <person name="Olson M.A."/>
                <person name="Rokas A."/>
                <person name="Carbone I."/>
                <person name="Cox M.P."/>
            </authorList>
            <dbReference type="PubMed" id="23448391"/>
            <dbReference type="DOI" id="10.1111/nph.12161"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2015" name="Fungal Biol." volume="119" first="503" last="508">
            <title>Regulation of the aflatoxin-like toxin dothistromin by AflJ.</title>
            <authorList>
                <person name="Chettri P."/>
                <person name="Ehrlich K.C."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="25986547"/>
            <dbReference type="DOI" id="10.1016/j.funbio.2015.01.007"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 9 10 14 16 17 18">Fatty acid synthase alpha subunit; part of the fragmented gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B (PubMed:12039746, PubMed:17683963, PubMed:22069571, PubMed:23207690, PubMed:23448391). The first step of the pathway is the conversion of acetate to norsolorinic acid (NOR) and requires the fatty acid synthase subunits hexA and hexB, as well as the polyketide synthase pksA (PubMed:16649078, PubMed:23207690). PksA combines a hexanoyl starter unit and 7 malonyl-CoA extender units to synthesize the precursor NOR (By similarity). The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by the fungal fatty acid synthase hexA/hexB (By similarity). The second step is the conversion of NOR to averantin (AVN) and requires the norsolorinic acid ketoreductase nor1, which catalyzes the dehydration of norsolorinic acid to form (1'S)-averantin (PubMed:23207690). The cytochrome P450 monooxygenase avnA then catalyzes the hydroxylation of AVN to 5'hydroxyaverantin (HAVN) (PubMed:23207690). The next step is performed by adhA that transforms HAVN to averufin (AVF) (PubMed:23207690). Averufin might then be converted to hydroxyversicolorone by cypX and avfA (PubMed:23207690). Hydroxyversicolorone is further converted versiconal hemiacetal acetate (VHA) by moxY (PubMed:23207690). VHA is then the substrate for the versiconal hemiacetal acetate esterase est1 to yield versiconal (VAL) (PubMed:23207690). Versicolorin B synthase vbsA then converts VAL to versicolorin B (VERB) by closing the bisfuran ring (PubMed:16649078, PubMed:23207690). Then, the activity of the versicolorin B desaturase verB leads to versicolorin A (VERA) (PubMed:23207690). DotB, a predicted chloroperoxidase, may perform epoxidation of the A-ring of VERA (PubMed:23207690). Alternatively, a cytochrome P450, such as cypX or avnA could catalyze this step (PubMed:23207690). It is also possible that another, uncharacterized, cytochrome P450 enzyme is responsible for this step (PubMed:23207690). Opening of the epoxide could potentially be achieved by the epoxide hydrolase epoA (PubMed:23207690). However, epoA does not seem to be required for DOTH biosynthesis, but other epoxide hydrolases may have the ability to complement this hydrolysis (PubMed:23207690). Alternatively, opening of the epoxide ring could be achieved non-enzymatically (PubMed:23207690). The next step is the deoxygenation of ring A to yield the 5,8-dihydroxyanthraquinone which is most likely catalyzed by the NADPH dehydrogenase encoded by ver1 (PubMed:23207690). The last stages of DOTH biosynthesis are proposed to involve hydroxylation of the bisfuran (PubMed:23207690). OrdB and norB might have oxidative roles here (PubMed:23207690). An alternative possibility is that cytochrome P450 monoogenases such as avnA and cypX might perform these steps in addition to previously proposed steps (PubMed:23207690).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="14 17">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="induction">
        <text evidence="11 12">Expression is positively regulated by the dothistromin-specific transcription factors aflR and aflJ (PubMed:23207690, PubMed:25986547).</text>
    </comment>
    <comment type="PTM">
        <text evidence="15">4'-phosphopantetheine is transferred from CoA to a specific serine of the acyl carrier domain by the C-terminal PPT domain. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.86" evidence="1"/>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EC" id="2.3.1.41" evidence="1"/>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJJ3"/>
    <dbReference type="SMR" id="M2YJJ3"/>
    <dbReference type="STRING" id="675120.M2YJJ3"/>
    <dbReference type="EnsemblFungi" id="EME39096">
        <property type="protein sequence ID" value="EME39096"/>
        <property type="gene ID" value="DOTSEDRAFT_66976"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RV4X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000114_0_0_1"/>
    <dbReference type="OMA" id="VGVAPKY"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000443458" description="Fatty acid synthase alpha subunit hexA">
        <location>
            <begin position="1"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="90"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="6">
        <location>
            <begin position="948"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ketoreductase (KR) domain" evidence="3 4">
        <location>
            <begin position="508"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1263"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1270"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="6">
        <location>
            <position position="1135"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="6">
        <location>
            <position position="1315"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="6">
        <location>
            <position position="1356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="1569"/>
            <end position="1571"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1569"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="1615"/>
            <end position="1625"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="1639"/>
            <end position="1642"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="1668"/>
            <end position="1670"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1669"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P19097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q12437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q8TGA2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="12039746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="16649078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="23207690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="25986547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="13">
        <source>
            <dbReference type="PubMed" id="17683963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="14">
        <source>
            <dbReference type="PubMed" id="22069571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="15"/>
    <evidence type="ECO:0000305" key="16">
        <source>
            <dbReference type="PubMed" id="17683963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="17">
        <source>
            <dbReference type="PubMed" id="23207690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="18">
        <source>
            <dbReference type="PubMed" id="23448391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EME39096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1692" mass="183262" checksum="B556CA38EFA88391" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKF8</accession>
    <name>M2YKF8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyruvate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_138869</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKF8"/>
    <dbReference type="STRING" id="675120.M2YKF8"/>
    <dbReference type="eggNOG" id="KOG1184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_1"/>
    <dbReference type="OMA" id="HGMNEAY"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF11">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="13">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="11">
        <location>
            <begin position="217"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="12">
        <location>
            <begin position="411"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME39456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="578" mass="63067" checksum="9C72FC2D2A4A8624" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKR3</accession>
    <name>M2YKR3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF427 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_91796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKR3"/>
    <dbReference type="STRING" id="675120.M2YKR3"/>
    <dbReference type="eggNOG" id="ENOG502SGFY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059611_1_1_1"/>
    <dbReference type="OMA" id="PYKGVAN"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310:SF9">
        <property type="entry name" value="BLR5716 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="2">
        <location>
            <begin position="154"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="278" mass="31613" checksum="12F8BCD9F2FD2487" modified="2013-05-01" version="1">MPPPPPDAKKLALKLGAEGPHQVLATPRKIQLLFNGAYVLRTIKASFVWEHPFYPQLYFPRSELERLKVEEGDVYKDDDGKVVAKQLILSINNKSIDNVIAWENNLPSKAAELNGLVKIDFAAVDQWFEEDTPIYVHPKDPFKRVDILQSTRHVRVKVAGQVVADTTSSMHLYETGLPVRYYLPLTSIDAGVLRKTKTRTQCPYKGEAEYYSVMVDGKVHEDVVWYYTTPLLESARIEGLCCFYNEKVEIELDGERLEQPDTHFGKHKPSDNVKPSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2YMQ9</accession>
    <name>M2YMQ9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_72572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YMQ9"/>
    <dbReference type="STRING" id="675120.M2YMQ9"/>
    <dbReference type="eggNOG" id="ENOG502S8KA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085422_0_0_1"/>
    <dbReference type="OMA" id="FATERPY"/>
    <dbReference type="OrthoDB" id="3928876at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16015">
        <property type="entry name" value="Promethin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="298" mass="31106" checksum="B4863FC96AEB067A" modified="2013-05-01" version="1">MADQLKNASSDVQEEAKDTTKGTPLSGAQEKVKTATDGVLGGLESYGSKISNKVKGMVDYIFPPDKRASFLSKLQAFMLANPKLSAFLGMNLALTGVPLGLFVLFSLTVFIFALVVALVIALLAAVLFTLFAVGTALLFVFPAVLFTTGTACFLFLWGLGGYYILRWANGDKEGAPKQAPEGHSIGDSLNRITGGRLDGFMQSARSQNAKNNNAGKNDRPTKQQHNTQSHDNGTPENRNGFAAGNHAKNAANDTSKYVGSVSNQATDAVSGATKPVANVSNTAGTIKGGLSGASGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2YMX3</accession>
    <name>M2YMX3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cdc23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_72635</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YMX3"/>
    <dbReference type="STRING" id="675120.M2YMX3"/>
    <dbReference type="eggNOG" id="KOG1155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018320_1_0_1"/>
    <dbReference type="OMA" id="YIMETER"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME43290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="371" mass="42231" checksum="8A6FEC8657AB3500" modified="2013-05-01" version="1">MTFFFHLHCSQELFQQEKAVYDVLGQMQSIFPRSAFLQQQKALLLYHARHQEEAGDVFDDLIRNHPHRLDGMEIYSNLLYVLQNRPKLATLAAMASETDKFRPETNCILGNYYSLIAEHEKAVLHFRRALQLDRNCQTAWTLMGHEYIELKNTQAAIESYRRAVDTNRKDYRAWYGLGQGYEMLECHSYSLFYYKRAASLCVADPKMWAAVGNAYSKCGKIVNAIQAFKRALIVGSQIDAGSSFNTSTADPLAHAVGGALDPQVLYDIALLYEKESNYQEASAYMELTLAQEDGAEDGEEGIGVTQVTSRARLWLARWCHAQSDWERTMQLANELIQDSVEVEEAKSLVNEVRSRLALAEQEKSELLRSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2YNR5</accession>
    <name>M2YNR5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_174642</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YNR5"/>
    <dbReference type="STRING" id="675120.M2YNR5"/>
    <dbReference type="eggNOG" id="KOG4534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_511984_0_0_1"/>
    <dbReference type="OMA" id="DQLWVGQ"/>
    <dbReference type="OrthoDB" id="3361892at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME43675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="524" mass="57684" checksum="53A650EB8DC34FCD" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBL9</accession>
    <name>N1PBL9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_75864</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBL9"/>
    <dbReference type="STRING" id="675120.N1PBL9"/>
    <dbReference type="MEROPS" id="M03.009"/>
    <dbReference type="eggNOG" id="KOG2089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_1_1_1"/>
    <dbReference type="OMA" id="KNFQSAM"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.40:FF:000001">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="225"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME38477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="714" mass="81476" checksum="34ECABA6A8370C29" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC54</accession>
    <name>N1PC54_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC54"/>
    <dbReference type="STRING" id="675120.N1PC54"/>
    <dbReference type="eggNOG" id="ENOG502S7AM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047435_2_0_1"/>
    <dbReference type="OMA" id="WIPAKRD"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142">
        <property type="entry name" value="METALLO-HYDROLASE/OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="425" mass="46125" checksum="26B242043EB51297" modified="2013-06-26" version="1">MSVTVQQYTADSTFLVTFAPPFAPVRYKGKFPGSLNILFDPWLDGASIVGHPKFATNKHTGPAAITSLAGLKDIDVIVISQEKSDHLHEKTLQTLPRDTKVKILATPKAAKKIYDWDYFVDPGIICVMSPYNATKEETVTRIPIEAYSSTSAQGEVTITNISEKRDLTGLHNAIGVTYRPPGTILKAADGTTVRISEMPGMSPSRPTTAKSSASSTVSRSSRSARQRYLRGALDDLEYYSPFVPQPNDDYETAPEPSFRSRADSAQGRPATSASRPSTSYNNSTRQGNHEKVLSILYTPHGIDPTKLRSYLSQHLHPLSGALPLTALFHSLNVESNPWWMGGLISAGAPGGVKLAKELDVRYWISAHDEIKDSSGVAVSFIKKQVYTPEDATKMLKKVQGVEGGRGIGTQVCVLGCGGQRRFVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCD9</accession>
    <name>N1PCD9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_91398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCD9"/>
    <dbReference type="STRING" id="675120.N1PCD9"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="OMA" id="RDPQICA"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF35">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="357" mass="39027" checksum="518BF16CAD22F04B" modified="2013-06-26" version="1">MWLITTILVLIAALTYGFPILLAEVFPWQYLWAQRKGRPTVKQYSYSGRTILITGANGAYGSRAAKVFATRDAEQIVLVDAKDCTALKSEIEANARAQGGPCPQILVWTIDMMTFKGCQELAAKAKELKSIDHVLLTMGILSFKRQESPEGWETSLQVNYLSNACLSLLLIPHLKPSPGNLNPPVLTFTTSFGIFPASPTMSLPKSGSYLKHLSNNKDGMAQKHQYGRSKGLLLYFARGLATRLSSATGLPKVTITSADPGTAWTGLTQPNKAELITRVITDFGARPPEFGAAALVNGVSADASMHGRILHDFDTVPYPPFMDRQSGVIAQERVWKETRAELETKVPGVKAVYDLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCJ5</accession>
    <name>N1PCJ5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_75928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCJ5"/>
    <dbReference type="STRING" id="675120.N1PCJ5"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023312_0_2_1"/>
    <dbReference type="OMA" id="FAWQGMQ"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14518">
        <property type="entry name" value="DSP_fungal_YVH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="68"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME38573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="323" mass="36062" checksum="60C7D0BD43610092" modified="2013-06-26" version="1">MSLLDRVQGDDELYIGGLFTLRRREALQTTGITHVLSVLRFQPDAELFAGYQQKVVEVDDVDDENLLQHFPETNKFIQDGLDSGGGVLVHCAMGKSRSATCVCAYLIHRYGISPDEALARIRENRPLAEPNEGFWEQLELYHEMGAPEDLESTPAYQRWVYLQEVKLSRACGQAPEAEKIRFEDEHSQGSGSADFDLRCRKCRRTLATSQYLIAHQPRVSDQSSKQASSACSHYFLDPLSWMRPELEQGKLDGRLECPKCKTNVGKYAWQGMQCSCSDWVVPGISLAKGKLDEVKSRTSSGPGFGIRVPPSANGKGGQGWENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCY7</accession>
    <name>N1PCY7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCY7"/>
    <dbReference type="STRING" id="675120.N1PCY7"/>
    <dbReference type="HOGENOM" id="CLU_1570613_0_0_1"/>
    <dbReference type="OMA" id="ANTDFGH"/>
    <dbReference type="OrthoDB" id="4220319at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="170" mass="18619" checksum="CF5C45933B07F943" modified="2013-06-26" version="1">MSLQQTLRSTFRTVSGRTTYAGSRSISLTTPWQSKKDETKDYGIESKDSLNPVYDEYSRSGSDQAAGQMAETAYTRGNNDPDAQNQQAREESKKQGRDSNPLEFSPANTDFGHQKAWASKEQGGPDMGAPKETLSGKGSGQKGGAGQRYRDPEKLSEETEKQKRDADAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCY9</accession>
    <name>N1PCY9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCY9"/>
    <dbReference type="STRING" id="675120.N1PCY9"/>
    <dbReference type="eggNOG" id="KOG2914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_0_1"/>
    <dbReference type="OMA" id="IWCPHPG"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990738">
        <property type="term" value="F:pseudouridine 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000131">
        <property type="entry name" value="HAD superfamily hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32814" checksum="3CA1A7581771E92C" modified="2013-06-26" version="1">MATRTDLPAIKACLFDMDGLLIDSEDKYTICTNEVLREYGRPDLPWRIKAQLQGRPGPAAGKILFDWAQLPIPREEYLAKVQASQKKHFLDCRPLPGVTSLLTTLWKKTDPPIHMALATSSHAGNFKIKTDHIQETFECFAQEHRVLGDDERIGKGRGKPAPDIYLLALKTVNDRLQREGKEKIKPEECLVFEDSVPGVESGRRAGMQVVWCPHPGLLNEYKGREERVLAGQMGEYKEVEKKNENIGVVSEDGGKVTSGAPGEIGDGCAILLNSLEDFPYEKFKIRIKKDSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD38</accession>
    <name>N1PD38_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_28137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD38"/>
    <dbReference type="eggNOG" id="ENOG502SEVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1065682_0_0_1"/>
    <dbReference type="OMA" id="RELYLMI"/>
    <dbReference type="OrthoDB" id="5348533at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="261" mass="29352" checksum="94FF42114EE0482E" modified="2013-06-26" version="1">MNKSANAKGKMTSMLELPRELYLMICDYLSPRDLARLAEVTQDHYLATQQPLFRAIKITAFGNLVKLVHTITKPPIVSTVSKKQRLRWQSLSDTQLREREIRQLGIVLYHACRDAAKVTGAVLSRCIGAVSRCNNGPKISINLHGSWYHLLRQLQSVPLPDVQVITMYLGQHEQEPSSAQRNPCMHVDLGFELWDLCFEGSNFPDLQQVSINTLHVSLKDLPTTLNKGASISDDLYRAAHGHGSEPTSFLPFFGLRNMTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD63</accession>
    <name>N1PD63_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpc2-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD63"/>
    <dbReference type="STRING" id="675120.N1PD63"/>
    <dbReference type="eggNOG" id="ENOG502RG9A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012566_0_0_1"/>
    <dbReference type="OMA" id="MDGDVPM"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="496"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="671" mass="70883" checksum="4034E1F58F3C5F96" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDA4</accession>
    <name>N1PDA4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_57519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDA4"/>
    <dbReference type="STRING" id="675120.N1PDA4"/>
    <dbReference type="eggNOG" id="ENOG502RBCG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_10_2_1"/>
    <dbReference type="OMA" id="FPLYVCI"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="36213" checksum="AE4E7A206446A376" modified="2013-06-26" version="1">MTHIPQAPQPQHDRLARFAGRNFSRFSLEHSIHCLPVDETEEDNCNEVNDILRQLLGRAVLPRLRLNETEEPQVLECGFQKAAWIDDILDACPDAWVVGIDIFTGQGTGDDSSEEDEDDGDRPDFYIKKRWNLNASFRTSHDLDLRPETFHLVNSRLFVDGINNGRWDSYVRELRSLLRPGGWLQMVEVHMLFQSDSGRGTTYLERWYQMYQQCLTAMGKNPRVGRQLQRLLTDAGFDHIHHAVHRLPMGGWLEGKETLGGQARDLMSKILRSASLWLFMRVHQPPLTPAQYEILITGAHQELLQDDLKLYLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDK8</accession>
    <name>N1PDK8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_29354</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDK8"/>
    <dbReference type="STRING" id="675120.N1PDK8"/>
    <dbReference type="eggNOG" id="KOG1936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_4_0_1"/>
    <dbReference type="OMA" id="CGGGNFK"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="287"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME38290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="498" mass="55305" checksum="A37D39E83A3278DA" modified="2013-06-26" version="1">MGKDKSTQFTLKVPKGTKDWDGKDMVIREKIFNTITEVFKRHGAVTIDTPVFELKEILSGKYGEDSKLIYDLADQGGELCSLRYDLTVPFARWLAMNSSVQNIKRYHIAKVYRRDQPAMTKGRMREFYQCDFDIAGAYDPMLPDAEILRITCEIFEALGWQGRYTIKLNHRKILDGIFLVCGVPTDKVRTISSAVDKLDKSPWEEVRKEMTEEKGLDPEVADRIGEYVVQKGGQELLEKLQKDGKLSSNDSAKAGLEDISLLFSYLRTFGILERISFDMSLARGLDYYTGLIYEVVTEGSAPQVADGTAKQKVKKSKSTDGDEDRSDDPSVGVGSVAAGGRYDNLVSMFSGKQQIPCVGISFGVERIFSITKQRLAADASAAAIRGNEVDVYVMAFGGKGFEGLLQERMDVAKRLWDAGIKAEFSWKVKPKLPQQFKAAEANSVPFAVILGDDELAAGQVKIKEMGLPEGHAEKDGVLVQLDNLVQEVQTRIAAQNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDL8</accession>
    <name>N1PDL8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_29574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDL8"/>
    <dbReference type="HOGENOM" id="CLU_1245319_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="222" mass="24658" checksum="0B89D1531217D34A" modified="2013-06-26" version="1">MATIPMTTAEMHTEHKEKVCCPFPIHHRTVTSPLPSARPTRGNASQMTLSPASRNWLGVERSGDVSTVFTLASLPPDHPHAFQRVKRRLSDVGERIAEIATSPKLSEKVKMKLGRKSCRSLRPPEMHVDGANDTAPQHLLPETMRTDQFDQDAQSLNSSELERVLDYMNIDSTIAPPPGRPWLGSSEAHIPCSPCMRSEEMRTIGTSLPRSEDMREVTNAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDQ3</accession>
    <name>N1PDQ3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_74888</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDQ3"/>
    <dbReference type="STRING" id="675120.N1PDQ3"/>
    <dbReference type="eggNOG" id="KOG1827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007728_0_0_1"/>
    <dbReference type="OMA" id="QKWINAC"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000048">
        <property type="entry name" value="RSC complex subunit (RSC1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="47"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="253"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="11">
        <location>
            <begin position="366"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="534"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="767"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="767"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME40234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="875" mass="99432" checksum="2D39375EAA256BD0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE55</accession>
    <name>N1PE55_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_136426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE55"/>
    <dbReference type="STRING" id="675120.N1PE55"/>
    <dbReference type="eggNOG" id="ENOG502TIW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160179_0_0_1"/>
    <dbReference type="OrthoDB" id="3535086at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="95" mass="10647" checksum="734FD3568B0532F0" modified="2013-06-26" version="1" fragment="single">PNAQHQQVRNGHTEAQQTQLMTLPRNQLEAMPPNRTHPMPSLPMQPMYNPATTHPVFFMNNFRKPPFPLPLTAGLNPVATGYVFAKDGTATRTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEY9</accession>
    <name>N1PEY9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_158433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEY9"/>
    <dbReference type="eggNOG" id="ENOG502SMYP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_7_1"/>
    <dbReference type="OMA" id="PIRPLME"/>
    <dbReference type="OrthoDB" id="3934549at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF165">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="49"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME39856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="361" mass="39425" checksum="A2EE61806E718520" modified="2013-06-26" version="1">MAILYGDEGVELIWITWVWTVLGSVLFGLRSFNAAKAREGMPSLLGFRCDYILIALAYALAVCAQAFVTVSYRYSTGAIEDPLKQLSHVLYWSIIGQMCAIFSMALGRFSVIAFLAALQGTVSPKARHLLFVLGGLQFCISTCQVFITLLQCDPPRKLWDISLPGSCPLDKIEIKYGYFSGSFGAFTDFVLAIYPAVLIVGPLQQMKLSLKIGICFIMAGGVVAGAAGICLVVYVEGVSYTGGYGTVLTWVMTQTWFIIIFGSLPAIRPVFVAWGESCRTLSARLRSRLSQRRAPTSDPVERMTWVEMQNPHAAGIDRKRGEWSASQTALSTAPQRPGVSKSARSDSDTLFNEDGIVSHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF95</accession>
    <name>N1PF95_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF95"/>
    <dbReference type="STRING" id="675120.N1PF95"/>
    <dbReference type="HOGENOM" id="CLU_1133659_0_0_1"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="219" mass="23890" checksum="694434E691A19351" modified="2013-06-26" version="1">MPIFNAGGKSDEWSKTEPLPTNDAGVLRIKGLVVSTVDKIANKTNDLHEVEAMLSHLDEVEAITSTLKIDPLTLGAVLLGGAGFDDTARATPAEVNVWPKYLKQIHAEKEHPPWLNHLESNADEQERALAMFNATFHNACRHRCFFSTMDGQIGIGPIRSRPGDSVVVLQGGLFPFVLRGKQDGQSELIGYCYVHGVMDGEAVEKLDRGAVEAAIFDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFD8</accession>
    <name>N1PFD8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_74576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFD8"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_0_1"/>
    <dbReference type="OMA" id="AWSFYLL"/>
    <dbReference type="OrthoDB" id="5298304at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901604">
        <property type="term" value="F:dethiobiotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015295">
        <property type="term" value="F:solute:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905135">
        <property type="term" value="P:biotin import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000399">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000278">
        <property type="entry name" value="Putative MFS transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF33">
        <property type="entry name" value="VITAMIN H TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME41087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="56086" checksum="8865BEA66A4646B0" modified="2013-06-26" version="1">MADLDHSQKSHLPAAHNSHLKEADLSSQDAEQADENGQPDAVRMRQIYRKLDMRIIPPFWLLYFLCSAVRSNIGLAQTMNTSDGHDLGAYLNITPHQVSTGLALFYVTYVVLEVPSNLAMSKLSPSVWLARIVISVGIIGTAMVGMRNAAGYYVLRLLLGAVEAGMWPGMSLFLTLFYPPHRMAKRVGWYFTASQVSAAVVGLVSAGFQKMDGDGGLVGFQWMFLLWGLVTLLFGFSLVWWLPDRPLIPGEERKRSWMNKFLPRPRPALTGDDAVLHYKDLKQAYHDSDWTMRDLWNVLIDWRFWPLLVMYFGVVGVGNGVQSYGTVILKAVNPSFSGVELSLLYAPIWICDLIGILCITPISDHFHRHRAIWFSIPTVLQIAGLLISTYAGNSSSEKWGRYVGLLIVGFGLGPTVPITMTWTAEIFQPRHGEIGVAAACALVSGLGNLGSVVTNYALFSGWPEDAKRSPVYVGSNWVMIGILLASIAASFLMTILLRVTGERSRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFE7</accession>
    <name>N1PFE7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase epsilon catalytic subunit A</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">DNA polymerase II subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DOTSEDRAFT_38266</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 25">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="N1PFE7"/>
    <dbReference type="STRING" id="675120.N1PFE7"/>
    <dbReference type="eggNOG" id="KOG1798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000556_0_1_1"/>
    <dbReference type="OMA" id="MLDQCRY"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="2582"/>
            <end position="2604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="2632"/>
            <end position="2650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="2680"/>
            <end position="2706"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="22">
        <location>
            <begin position="1520"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="2406"/>
            <end position="2425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="2409"/>
            <end position="2418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EME40300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="2712" mass="307693" checksum="13F9BAD13ACCD99A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFS7</accession>
    <name>N1PFS7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_176641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFS7"/>
    <dbReference type="STRING" id="675120.N1PFS7"/>
    <dbReference type="eggNOG" id="KOG1177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_1"/>
    <dbReference type="OMA" id="EQICAFV"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF30">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="492"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="591" mass="66497" checksum="FB80988FC5C10F08" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFU2</accession>
    <name>N1PFU2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_26409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFU2"/>
    <dbReference type="HOGENOM" id="CLU_1094260_0_0_1"/>
    <dbReference type="OMA" id="NDIGYLW"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="254" mass="29406" checksum="9C9F197D9EE0C062" modified="2013-06-26" version="1">MAGPRKFEKHSLAYRQYKALKRLPPACPPYSYAASGYPQVQQHELYCRQPGTDGQLCGYYKHNDIGYLWNHLEKKHGFQRQNRPSFQSLTWSEERFNELNLFYTELMKAMKEGGEHAKQGLRRSGRDQRPAYGTYSKDDEDDEEPAIMQKREAGSQRHESVKIQRPMQRKHSRIVDEQDVEMSTQEAMLATNGMTAKRKRDIDGEVSEYDEASLQAQLKEKKAKQEMKAAALEVKEAAFEVAELEAKLAVRKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFU5</accession>
    <name>N1PFU5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_26414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFU5"/>
    <dbReference type="STRING" id="675120.N1PFU5"/>
    <dbReference type="HOGENOM" id="CLU_068279_3_1_1"/>
    <dbReference type="OMA" id="HDAITIH"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="167" mass="18962" checksum="33EE2A9C3B80A69E" modified="2013-06-26" version="1">MSSEDGPAKKRQRHSGPIVVLTVGKNAQAFNVHSEYLRDHSPVFNNLLEHSWIKKVVHEIDLPDDCVDVVGTYVDWLYNRTLGFHLETSLTGTTSPDHNLFVALYCFGQRVQSDAFCDIILSYMLQYSQKYDLWPSPHVVKAAYAGTIAGRPLRDCLIEIYADKMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFX1</accession>
    <name>N1PFX1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFX1"/>
    <dbReference type="STRING" id="675120.N1PFX1"/>
    <dbReference type="eggNOG" id="ENOG502SKRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_14_2_1"/>
    <dbReference type="OMA" id="VFEWSMS"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF14">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="37"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="558" mass="62332" checksum="561E638F6F2295B1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH14</accession>
    <name>N1PH14_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH14"/>
    <dbReference type="HOGENOM" id="CLU_827824_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="336" mass="36460" checksum="760938B6DBFE1169" modified="2013-06-26" version="1" fragment="single">MEHSPPKDNGPLHTIQLVGTLPLTAVSWSETMPPHEESSLYDDDKICTAALDSSANAHLFVSARSFVPSEYCSTSPAISHSNYSIAAQPTKHLRIPRAARDSHFRATYRCPSECLASSGFSYARGFRHALHESLQPLLRPETSTINQCTQAALGTCRHLTFKQIVSSYLQKSCCTLWPTSIALHRPTNFGGRRLDKQTICSERPRRVIVIPRGPCDDSNPHFEVECMTGCVGGPPAPRSDATIHKSTLEHESSADIAPPTYQPEIECLGPCFVPGYLNECSTLLLRESRGPGTEESTAADISATLSAISSVDTTAWAWGFATMIVIHISGGISGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIN4</accession>
    <name>N1PIN4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_26582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIN4"/>
    <dbReference type="eggNOG" id="ENOG502SRKY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_874436_0_0_1"/>
    <dbReference type="OrthoDB" id="5030973at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="318" mass="35656" checksum="9668BE85BFFC1E25" modified="2013-06-26" version="1">MADSRGIQTVEQWNRAQKNGKQSYLYEEQQSEYDRIHGGLKTRNPLNDPWQRSAVYTTSNERSPFRKSVSIAICAHGEESSASTTIDLSLIVFHVKLSCAEEKRYKSARLDFKFAKKDPSDLTAPEVVNWGPFMKEKRGDGSQEGVTTTKSIDGSLGVDQHAKGELSAGIETTLEYSKRYFKKSFSEAVHDDESGKDIGVRWHFAQNYSQNDGVDPDFHVAILVKPGKDKDGKARPFLGSLGFRLNAGVLDDVKQGIERFFASRNDPVWYDPKLAMQSYITGDRVKEDVAAKLMNLGVYKKEVVLSELVANIDREATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIU1</accession>
    <name>N1PIU1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIU1"/>
    <dbReference type="HOGENOM" id="CLU_2922613_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="61" mass="7153" checksum="9A70D5648CFB4AFA" modified="2013-06-26" version="1">MASDIKAWILHSRGPDRSEEVGRREQYFAVLRMVDDKYDTGLDYVGASKLLKLQRDYEEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIV9</accession>
    <name>N1PIV9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_73784</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIV9"/>
    <dbReference type="STRING" id="675120.N1PIV9"/>
    <dbReference type="eggNOG" id="ENOG502S3FG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007607_0_0_1"/>
    <dbReference type="OMA" id="CHTCETQ"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME41485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="666" mass="72167" checksum="D8AB2626C5E2EC0B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJD3</accession>
    <name>N1PJD3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">L-ascorbate oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_133360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJD3"/>
    <dbReference type="STRING" id="675120.N1PJD3"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_8_3_1"/>
    <dbReference type="OMA" id="QWPIAPH"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13873">
        <property type="entry name" value="CuRO_2_AAO_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13895">
        <property type="entry name" value="CuRO_3_AAO_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035666">
        <property type="entry name" value="MCO_CuRO_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017762">
        <property type="entry name" value="Multicopper_oxidase_fun"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03390">
        <property type="entry name" value="ascorbOXfungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="88"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="343"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME42522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="58312" checksum="E4666A01CB53C45D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK20</accession>
    <name>N1PK20_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_90041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK20"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OMA" id="TINCFTW"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME42737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="48537" checksum="299D970862AAFF9B" modified="2013-06-26" version="1">MAQGVQKNGQRYTAGLEKSEEATSQHDDTAPTTETIPSIIEPTANAPIDADIPPDGGYAWVVCGAISMINGFTWGIAASYGVYISQYLATDYFPGATPLDYALIGGLEFGVAMVISPICTILTRDVGRFWIMSAGCVMFAGGYIAASFAKEIWQLYLTQGVLVGLGLGCVFIPSVQKRSLAGGIASAGSGFSGLAFSLGTNAMIEQISLGWALRMTGILCLVGNFCGTCLVRDRNKMVKPPQMGFAVHLLKRYDCLLLIGWAFINLFGYMTVLYSLSNYAVQVGGLTQSQASVLTAILNLGTGVGRPALGVISDHCGRTQTAAVVTLLNAAFIFAFWIPATSYGFLIFYALIAGATVGIYWMTVGPLCAEVAGLAEVPSFPSIQWLTAVLPTTFAEVIALYLRRPAKGRWDYLYTQLFAAIAFLVASLCLFELWRIKANRGELTRSRWHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLT8</accession>
    <name>N1PLT8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_71700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLT8"/>
    <dbReference type="STRING" id="675120.N1PLT8"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045030_1_0_1"/>
    <dbReference type="OMA" id="PQTAWLN"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="448" mass="49353" checksum="A0FFF5320427FD1B" modified="2013-06-26" version="1">MASASAAEAEVPAEPASRPNGDNDQQVQYISAGVEASPQAVAGAETHEQSNGTAGATARPPVEPDTRPAVLIIGGLGYIGRNLADYIHRNQLASTLRLVDKQLPQLAALAPEHQEACSEKNFVQADASREQSQPRIFDLPPNADGSVREFEYVFNCGGETRFSQEDEVYKLRSYQLSIAVGKEASRRGVKAFVELSTASVYNSKKDPVDETGKTSKPHTKQAKWKLAAEDELAKISGLKLIILRFPNVYGPYAGRGWLGTQLALARVYQSREPKETMKWLWSGELRTNTLHIEDAARACWEAASWRAQNDRAPNSKDDTNKIVFNVVDNGRTTQGSMAAIIKQIFGIETGFYNALVNTFARLNLEHVVDDVNDDTLDDWADLQEAAGISDKGGPLSPFMEKEILRDADLSIDGGRFEGVVGFRPQHDRITTEQVEKVIESYKTMGWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PME0</accession>
    <name>N1PME0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_73424</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PME0"/>
    <dbReference type="STRING" id="675120.N1PME0"/>
    <dbReference type="eggNOG" id="KOG1742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109163_1_0_1"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="8">
        <location>
            <begin position="72"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00080124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME42576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="149" mass="16801" checksum="8EA1772B50A1BEF9" modified="2013-06-26" version="1">MPTRLSNTRKHRGHVSAGHGRVGKHRKHPGGRGMAGGQHHHRTNIDKYHPGYFGKVGMRYFHKLQNQFWKPVINLDKLWALVPQEQREKYLAGGSKDTAPVLDLLPLGYSKVLGKGRIPEIPLIVRARYFSKDAERKIKEAGGVVQLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMF2</accession>
    <name>N1PMF2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_73451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMF2"/>
    <dbReference type="STRING" id="675120.N1PMF2"/>
    <dbReference type="eggNOG" id="KOG4401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073383_1_0_1"/>
    <dbReference type="OMA" id="CPITNLI"/>
    <dbReference type="OrthoDB" id="1057137at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="2">
        <location>
            <begin position="121"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="236" mass="25459" checksum="E9ADDA7214C91D22" modified="2013-06-26" version="1">MADTKRNSVAGKVATPKSGGSPAMPPLQDPFESLGKVIGAKVKITTSAPQSQTLEGTLYTADPILNIVAINTRAPSPNGTAQPGDYHIIPSSTIRSFQIVDLAPFGTAGDSNFADAAPSIGPIDPRQLLKREETRVAQLKEQEANRGKGVSKDGQALFDALKRINMQVRWHGQQIVVNDIAIISPPYEVNDVKGSQEKQAETQRIKKIVEGEKRKLREKEDKERKAATPTGTRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMG5</accession>
    <name>N1PMG5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_175929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMG5"/>
    <dbReference type="STRING" id="675120.N1PMG5"/>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_0_2_1"/>
    <dbReference type="OMA" id="GHTMRDN"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="39590" checksum="E58BDE60FFDDA5AD" modified="2013-06-26" version="1">MANNDANPPAGVPQPVGATSDIAPSLLAPFGADEDDADSTYGGSVAGTDTTSLLSSIARYREENGRTYHSYGTMEHWGPNDDKAQDQQDLSHHLWGLALKGQLFLAPVEEPQEVLDIGCGTGIWPIEVAEQFPDATVKGIDLSPIQPTWVPPNLFFEVDDYNMDWLDEEKFDLIHARELLGTTPDWPKLYQRAFRALKPGGWLEQHEPSLFFLSDVVKFEKDHPFPQWGQLMVEAGEKAGLRFDIGAEMKGWMEQAGFVNVTEYRMPWLIGGWSKDKHQREVGQWNQLRLDLGIADFCSRRFHNQMGLTPEEIEVFCARLRLAFRDKSLYGYQWAHFVYGQRPLSASNGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN26</accession>
    <name>N1PN26_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN26"/>
    <dbReference type="HOGENOM" id="CLU_1415130_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="192" mass="21133" checksum="7F2328F8D54C3B2F" modified="2013-06-26" version="1">MGSGRVPGNGQEGEFEELRIQNEGKDLKITGPKVDLSKIDTRNNRQLAAVRKMQARLDEANAKIAEQSTGRTESQSDLNRAKHQNAENTTKIKDLERKLAAREVTASTQATQSRGLQAQVETNDTTISAQSTNIRNLRDSLKAEESKGSQQTTRIAELHLQAAVKDTTISEQTTKTKDLEGKLETEATKTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNA2</accession>
    <name>N1PNA2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_117938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNA2"/>
    <dbReference type="STRING" id="675120.N1PNA2"/>
    <dbReference type="eggNOG" id="ENOG502RFFW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011640_1_0_1"/>
    <dbReference type="OMA" id="HNNWNGF"/>
    <dbReference type="OrthoDB" id="5324692at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="54230" checksum="59B824BB0281FBBD" modified="2013-06-26" version="1" fragment="single">QQYRPPLKRCPHTGQGINFPTHFFRFTGIEDFWICSKCFEDDVKSTRAMDFCEQFYFDPLPGCDSVCDWQGTPRVRQLLNNAVRNGGVDALMEYARNRPAAGVCQGQKAVRGGQGQKWFGTPEIPNFIACEACYEDYIFVTPMASRMAPKSPESHETNDLWSCDLSIPYVRQMFLQQQQGSDLINAIKHRMSLPSCLGFSQIAYKNSRRWFRPVLPHPIERMMVCEACFLDHAGGLPVAKNFQEVRIDVREGVTRWICDFQLPPLKACTPDLMEKHYELWYGIAAKVVTFPCCEQQAIRDGDWYALQHPEDSRRIVDNFELCAACYIGMIEPCGFAGYFRQRRYNPGSERVCDFSTLNKGRHHVFRLKYREMVFRGDPFPLMDIAHRLAPLPVCPGGRFVQNRRWWGMNEFFFCESCYEELGRDSYFAPSFAHQRQEHAEACCDMWSTAMRQRYIQACRSKDLTQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNH2</accession>
    <name>N1PNH2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNH2"/>
    <dbReference type="STRING" id="675120.N1PNH2"/>
    <dbReference type="eggNOG" id="ENOG502REF4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_14_1_1"/>
    <dbReference type="OMA" id="FEACADI"/>
    <dbReference type="OrthoDB" id="2107174at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07505">
        <property type="entry name" value="HAD_BPGM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044999">
        <property type="entry name" value="CbbY-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896:SF2">
        <property type="entry name" value="CBBY-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896">
        <property type="entry name" value="XYLULOSE-1,5-BISPHOSPHATE (XUBP) PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27955" checksum="9190C585AE25801E" modified="2013-06-26" version="1">MGKVKYILLDCDNTLCLSERLAFEACADLTNEVMEKYSIDARYTTDSLLEDFVGNNFRNMLIGLQKKHNFSMTEKDVDEYVDMELGRVTAKLSEKCKECPGVTEQLEWAKAQGYPMSVVSTSAKPRVVASLQKTNLMRFFEDKHVYSAATSMDKPSSKPDPKIYLYACEQLGVKPEDCLTVEDSKSGATAAMRAGIPLIGYVGVYGLEEGKEKEEQMAKTLTDVTKADVIMYDWKQFPECVKKIEEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP55</accession>
    <name>N1PP55_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Choline transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_71837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP55"/>
    <dbReference type="STRING" id="675120.N1PP55"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_6_1_1"/>
    <dbReference type="OMA" id="NAYACVY"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF1">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME44150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="59662" checksum="7B0D5D0E95A1E907" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ63</accession>
    <name>N1PQ63_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_152436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ63"/>
    <dbReference type="STRING" id="675120.N1PQ63"/>
    <dbReference type="eggNOG" id="KOG0814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_6_2_1"/>
    <dbReference type="OMA" id="PTWILET"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24826" checksum="85DA5CDA4F7F71A2" modified="2013-06-26" version="1" fragment="single">MASCPMNTYSGSFTGSNDYVIHDFFDSSTSSWQYVIVDPGTRSCVLIDPVLDRTKDKIAISTTAADRLLSFVKSNSYRVDIMLETLSSSNNNRSGAWYLRSQLLKIQGHAPRVCGTQAAQPFGKLFARKYGFAPSTNSDEEFVDGDSIHVGHMKITMLQLPGLHTPDGRAYQIGENVFGAHSVASLKTKMQQDSASLRTTGADGIHRAWSSFQKILGMPAHYRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQB5</accession>
    <name>N1PQB5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_71349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQB5"/>
    <dbReference type="STRING" id="675120.N1PQB5"/>
    <dbReference type="eggNOG" id="ENOG502SNAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_581424_0_0_1"/>
    <dbReference type="OMA" id="WMLAMME"/>
    <dbReference type="OrthoDB" id="4525788at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="49"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME45621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="470" mass="53269" checksum="7C3019EF2A001216" modified="2013-06-26" version="1">MPGNFYTPTVEDILKWPKANYTNPPEQQHWLVPFVIVWQVISTILVAGRIHLRATKRSGPFGIDDILILLAWISSLALVVSACRAEWTFHLGRHIWNYPPQDFAGSLLNGWLAQIFFLLASTFTKCSILLFYRRMAKNTYSDTWLRTIWVLMFVTIGSGVGIFLAYCFMCEPLNFYWDFLYLDSKNEPASCINGDAVTIATGTITIASDFWTAALPCIMFQKFDVGATRRQKILLNCLFCVGFLVTGVGVARTYYLWKMGHDEDLSWWGYKLFAVSVVETQLALIVVNVPFLRAFFRRYFPSFTTQTSQTGRSRTTAAAQYSGTEWNANPRSSFVTAYTTDENGKVYPLSDCSTAKSPTEGEMFSTVEAEEMEWARRQVQQSNYMPRASDSPAGSFEVDEAEQKEARERMRRHEATLSTTAAQEQEKARAQVQAWVTKRPARDGDEDPILPNMSPTAASNPSWPRPSVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQR9</accession>
    <name>N1PQR9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_171312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQR9"/>
    <dbReference type="STRING" id="675120.N1PQR9"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_3_1"/>
    <dbReference type="OMA" id="IQRPLHM"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="43"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME45732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="484" mass="53398" checksum="09F6A96CA9B68EAC" modified="2013-06-26" version="1">MTEKTPSITSDLTGAQYLNATDWVSPDDPDNPRNFSLSRKICSTIAFTGLAFVSTFAASIYSPGSSLFRHEFDCSREIAILPLSLYNLGMAFGPLVGSPLSETAGRKAVVLATTPMFAVFTLGAGFSPNVAGVIVCRFFAGIFAAPAVGNASATITDYTAGRYRAIVMSFYYAIPTFGAVLGPLVGGFVVQAQGWRWTQWVTIFLILVFYVPVIFTKETYKKTILQRRAKRHGVQGPATEHMSPLQTVRHYATVLFLRPVHMLFTEPIVSLVCLYSGFLFGLMYAFVTASPWIYEHYYDFDLSGQALSFLGLISGALCASLPLVLLDLTIYQPRLARFPTTHLDTDRFPPEHRLYPAMIASPLLPTFLLIFAWTVRSDILWIVPIIFQGLAMSSSVMIYAPSNLFMIDAYGSLYGASAAGAAMLSRYSFSAAFPLFSLQMYHVLGVGWATTLLALCTAVMAPIPWLFWRFGDRLRARTKYETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR05</accession>
    <name>N1PR05_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_23404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR05"/>
    <dbReference type="HOGENOM" id="CLU_1427948_0_0_1"/>
    <dbReference type="OMA" id="LTHDANI"/>
    <dbReference type="OrthoDB" id="10537836at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="190" mass="20734" checksum="7E2F9C87C25AC09E" modified="2013-06-26" version="1">MLTFDPPIEVSSSQTTTAAAAEAAQNRLTHDANISTLTTTRPPSPALKPSSRLTLVEVESLKDTNDGIIADIQNEGFSVATTNQILLRLQSPYKHKRPVIPPEHVHLGEVMLIAFLMPESLQENRIKSMGLGPAYAPPVSDSTKPSLSDVQAVAKSRKAEPRRRTALPPSQKWKRSGSTYHFVDDDEVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRE7</accession>
    <name>N1PRE7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_168167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRE7"/>
    <dbReference type="STRING" id="675120.N1PRE7"/>
    <dbReference type="eggNOG" id="KOG4008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036234_1_1_1"/>
    <dbReference type="OMA" id="GIHKWIA"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12293">
        <property type="entry name" value="dRRM_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12950">
        <property type="entry name" value="RRP7_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="189"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME45962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34652" checksum="C9D48B1693B58124" modified="2013-06-26" version="1">MAGPKTPSMVHDFVVLPLRLPRQPSYPQESTHYLYLRANAPKAPTENTPREVFLVNVPVDATETHIRSLFADQLGGARIESLAFEGARVGKGISAPVAPAQSKKRKRGVDENEATTEAEVGLLPETWDRELHRSGGIAIVSFVDQASAQLALKEAKRAVKSKKDITWGAGISNKLAPLGKARYLSHHRLRYPDHALLQQSVDSFMVAFSAQEEARARALAKQRSEPDEDGFITVTRGGRSGPAREEEVKAKEEELKKREKNRIKDDFYRFQVREKKKDHAKDLVRGFEEDQRRVEEMKKRRGRIRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS20</accession>
    <name>N1PS20_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_34189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS20"/>
    <dbReference type="HOGENOM" id="CLU_1261480_0_0_1"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="219" mass="24097" checksum="7D25E711A9E12551" modified="2013-06-26" version="1">MAQSACLCKCRAIGMGTENNIHPSHDVWLGLDVDMQTSSKTRVGPANDPPYVWPFPLTNKSLSGSGVFNSDPDIISFVPTNSISFRDYYWRYPLPGSATISQPNQANFPKVTLRPTKPAPPSPAAINFPPLYLPSPLPLKRPLSRPASLSSSSQNYHEDLANARFNSSTGKITAALHLRSVSVDRSSTTNIYTIFPLPERHPRLPLPVAWKDAEFRLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSA4</accession>
    <name>N1PSA4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_71121</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSA4"/>
    <dbReference type="STRING" id="675120.N1PSA4"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_3_2_1"/>
    <dbReference type="OMA" id="TASKIMR"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF83">
        <property type="entry name" value="DEHYDROGENASE (CYTOCHROME), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME45304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="561" mass="61137" checksum="D454C7169D18821D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSC5</accession>
    <name>N1PSC5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate-binding module family 21 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_43631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSC5"/>
    <dbReference type="STRING" id="675120.N1PSC5"/>
    <dbReference type="eggNOG" id="KOG3986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012287_1_0_1"/>
    <dbReference type="OMA" id="TYSKAVH"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="317"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="628" mass="68780" checksum="FECF2149413BF863" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>N1PST1</accession>
    <name>N1PST1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_147840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PST1"/>
    <dbReference type="STRING" id="675120.N1PST1"/>
    <dbReference type="eggNOG" id="ENOG502QVWI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005937_0_0_1"/>
    <dbReference type="OMA" id="MGNTGMF"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF88">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="721"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME45993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="761" mass="84927" checksum="617A5851D08BF359" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUS5</accession>
    <name>N1PUS5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUS5"/>
    <dbReference type="HOGENOM" id="CLU_1835128_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="140" mass="15925" checksum="0EE6F7AC6C8F9244" modified="2013-06-26" version="1">MWLLHSPVTTATSTLLKWSGHLQPDPCSRTERARCLYFTSNCRGILVLSQQLKGVIELLRRCSPLLSSALAPWQHQQPRPVDDIGEASKCYSGCSPRELRDMGYMLAYNSDSEDFNIMPLAQHTRAERLRRQMLAKHAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUU4</accession>
    <name>N1PUU4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUU4"/>
    <dbReference type="HOGENOM" id="CLU_2960712_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="59" mass="6422" checksum="BE56F828304ACF85" modified="2013-06-26" version="1">MTRTGRQVAVDISSSLTPTSTVHNHSVLNSDCLTLVTPAQPGQRSWSSWEAPRWSSSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV48</accession>
    <name>N1PV48_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_21042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV48"/>
    <dbReference type="HOGENOM" id="CLU_1390202_0_0_1"/>
    <dbReference type="OrthoDB" id="10571804at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="196" mass="22344" checksum="120F88A6C197AF3E" modified="2013-06-26" version="1">MKARGEALAGSRIFLMTPNDNGKAVKTYPFGQIGALPGLITENGSTILPGFDDIEIQQIVNSTCLALRALDRAFKHHESFMERNWPRSIRAKYNCESKTFATSGALRDHMRRTHNIIASTLILHRDYTICKFCQRELLWSEWNNHIVHQKGKLKGETRICLVTDQENWPEACNVRAPRTTQERADTLGYKVESRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVI8</accession>
    <name>N1PVI8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_20777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME46953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVI8"/>
    <dbReference type="HOGENOM" id="CLU_628543_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="436" mass="49198" checksum="547115AB9AFBEA03" modified="2013-06-26" version="1">MDHFAPVPITSSSNAPRTAAEPTWQEQGLQNMDEEQYPVILDHEQGTSEQGTRVMTHESPRHPDNVCGHWFEPVAPTMAGFDENNLPLCTRCRLEQRFLDKEKAEEHTEQLKRQIRELKRDLWLHRQYEATLQQEQGELFERVNDLNQQQWNRERENRALPEHLRNLLNVYDEDVAAREREDKQPAPRNEFFASGHDDAGQPAAGEQGEGEQGEGEQGEGEQPFHTDEELALMLVSQYRAEHIGESSTTPLDQLFASTLDFADDENQIEYGSSGKAENTSEDTANDFLDTQNSWEDQHTSEAAQNTFQEAESDAWGRENTAQGEDSGWGAENTIIGAEDSGWGVENNVTETEDSGWGVENTVPVAEDSSREAQNTTSGSQQPDAPCIVLLSDDEYAEALASQYRYDQRAANLASVAAFNVRNKHRFQGSLWPQKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVM6</accession>
    <name>N1PVM6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME46993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVM6"/>
    <dbReference type="HOGENOM" id="CLU_3068649_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="53" mass="5795" checksum="C83BE55E76E5EE11" modified="2013-06-26" version="1">MQLQYIPHLLSNHDSNVIASTTSCSNLKLCIHTSNTSPSASELQEAVPSLRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW64</accession>
    <name>N1PW64_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytochrome c oxidase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Cytochrome c oxidase polypeptide VIIA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_70564</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the fungal cytochrome c oxidase subunit 7a family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW64"/>
    <dbReference type="STRING" id="675120.N1PW64"/>
    <dbReference type="eggNOG" id="ENOG502SBM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196969_0_0_1"/>
    <dbReference type="OMA" id="ASYWWWG"/>
    <dbReference type="OrthoDB" id="2317211at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014368">
        <property type="entry name" value="Cyt_c_oxidase_su7a_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000283">
        <property type="entry name" value="COX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME46595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="62" mass="7108" checksum="F91149F9D3BB9BFF" modified="2013-06-26" version="1">MPIKPITGMLRRGLVLDLSVAFGLGTSFGYFWWYGFHVPSVRRRDQFYAKLEDERASALGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWF3</accession>
    <name>N1PWF3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enolase-phosphatase E1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_51065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWF3"/>
    <dbReference type="STRING" id="675120.N1PWF3"/>
    <dbReference type="eggNOG" id="KOG2630">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023273_1_1_1"/>
    <dbReference type="OMA" id="LQGMVWE"/>
    <dbReference type="OrthoDB" id="272500at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME47727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="36700" checksum="EE46464027FF1BC8" modified="2013-06-26" version="1">MDGIKCVLLDIEGTVCPISFVKDTLFPYALRALPEVLANKWDAPDFKLYRHAFPEEHRDNPRALQAHVEDLTKRDMKIAYLKNLQGFLWENGYKTGAYSTPLFPDVAPALKQWKDAGYALAIYSSGSVFAQKLLFGHVQVAADDSSATKKRNRPADDAAEDQASAADAPPPSKSKQTTSCFTYGEAVEPPALDGTDTKVGAESGPKHATQLADVDGGEQATDAATARLDTKAHENEGKPREVETEDMTALFNGSWWDTTSAGLKTEVGSYSKIAKSLQYAPAQMLFLSDNVKEVDAAIGAGMKSLLVDRPGNAAVSDTDKERLDIVTSLDQIKLPSKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWN5</accession>
    <name>N1PWN5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_33366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWN5"/>
    <dbReference type="HOGENOM" id="CLU_1209806_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="229" mass="24933" checksum="699F65AD37A1E382" modified="2013-06-26" version="1">MNSFKHEAIGTCTYITNRGRVGGKFKLRGRKHRRETELQREAPLRVGTIDATENSQGNRKNNGDEAANAGGDHLSSLRQAVAMWTIGAASADWRQETRKGGRDYRSTRPSRLLVPIRNFNTRNYSRYSRSIDKAVKKAASIAAKQAYIAASCQRQSEGSRPNRALSASSSDIEATSSILSLPGTITSPPCNTTTTTSDRIIQPLVSSQIPSQVSLRCTPPTKIGADALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX87</accession>
    <name>N1PX87_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX87"/>
    <dbReference type="STRING" id="675120.N1PX87"/>
    <dbReference type="HOGENOM" id="CLU_1758763_0_0_1"/>
    <dbReference type="OrthoDB" id="3942661at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="148" mass="16087" checksum="5EC13B1C6C95E849" modified="2013-06-26" version="1">MDSRRAISSLSVSKYGVMVDEKSVDILLSGDNPDAAVNKVRADSFCSGDFDMTEEELDELVPPKPAQLPAIQAPKPMPPPPMPARATKKVQTRAPPRPRTIMMKPHSAIKGPFLPASSLYCSPDFGFTSTQLESFIDDDIQLSQAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXJ6</accession>
    <name>N1PXJ6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_69174</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXJ6"/>
    <dbReference type="STRING" id="675120.N1PXJ6"/>
    <dbReference type="eggNOG" id="KOG2344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010236_4_2_1"/>
    <dbReference type="OMA" id="GIIRAGP"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="247"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME47115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="632" mass="70422" checksum="ED9C31377134C85C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXW5</accession>
    <name>N1PXW5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_42499</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXW5"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OMA" id="KRFRGAM"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="27"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME48267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="550" mass="60505" checksum="55EBD63A75B4AE1E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY33</accession>
    <name>N1PY33_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY33"/>
    <dbReference type="STRING" id="675120.N1PY33"/>
    <dbReference type="eggNOG" id="ENOG502QQEZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020826_1_2_1"/>
    <dbReference type="OMA" id="TAETWAH"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="485" mass="52557" checksum="6A1198CAD9C21CC6" modified="2013-06-26" version="1">MKKTLLLVFIHGFKGTDHTFQSFPKDLKSALALSLRKIDVLAIQYPQYETRGDLKDCVARFKEWLQNKVIDLEVANRTPSPTVDPSVHVVLCGHSMGGIVAAEALLSIARDEPVPSSLGNDGTNATVSHGSAMDDSTDRPREPSRLFFPAVQAILAFDTPYLGISPGVLAHGAEDKINQSSQAYKAWDQASSFFGWNSPKSGSSTPIANASSRGLPAQNSTTSEGSKWGKYAMYGGAAAAIAGVAGAAYLSWNQINQGLTWAGSHLEFVGCLARGAELQKRVEKVVDLTKTHGVGFANFYGALDEKVTSHTKYAGAFLGDDRTFCVVPKTARTAGSPTGSKRDQPKSRDASPKPKRRKGQEREADAAMDGEMEQGEKVREFADDTSKSKGRWVKCINPSVHDELSAHTTMFTPSKNSDYRTMVPRARDQILEWILVDSDWYEDAGEEEGHSKKEDENATAGDEAGMQDEDVEETEEAEAAASAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY71</accession>
    <name>N1PY71_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_48945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY71"/>
    <dbReference type="eggNOG" id="ENOG502RNTH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_729628_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012903982" evidence="2">
        <location>
            <begin position="16"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="379" mass="39490" checksum="5ACC8AE255219EA3" modified="2013-06-26" version="1">MFKALLLAIVVGVGAANISSPNLVDRANDSPSKECCIKDRCPRTAQQSAVTAYCSSYLKVPKTATKTVTTCSTTTILSTSITATVTVAGTTTTSIITGCQLPATATTTASASQTPTGGDSSVPAPEGKRDAESETHERRDDALSKPSCLSSHRTLQDISSVCSCLSLRPQTTKTTTSTDVKTINKTVKSAATVTGGPSTTTVYQAPANPTFAIVNDAGDIFRALCGQRRRALMSRQADNCQIDQIQFYTNSTSIETRVVNFVLNGADGLDGTLFLSSTAQAGQNMGVPTVANRKGGAQDYVVRNDPASPNSASLTPLTCSISFKSADGTCPLDCQPSGDDSDVNQSQNQDDSGTWYLGPAGAVSSNTFNNFAVSAELID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY93</accession>
    <name>N1PY93_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_19024</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY93"/>
    <dbReference type="STRING" id="675120.N1PY93"/>
    <dbReference type="eggNOG" id="ENOG502QPHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020817_3_2_1"/>
    <dbReference type="OMA" id="GACCAEL"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109191" description="Glucanase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME48496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="454" mass="47940" checksum="A5D0081185F2E88A" modified="2013-06-26" version="1">MSLTLAFAASLFSAGIRAQQAGTNTAETHPTLPISSCTAAECLNLGTSITLDANWRWTHTVDGSTNCYTGNEWDASICSSPSVCAASCALDGANYESTYGISTAEDSITLTFVTGANVGSRNYLLDKSGEKYQMFDLRNKEFTFDVDVSKLPCGLNGALYFVEMPADGGLSTQENNKAGAKYGTGYCDSQCPQDVKFINGEANIEDWTPSSGDPNSGTGSKGACCAEMDIWEANSISAAYTPHPCNGTGLQVCSDNTTCGAGDSRYDGICDRDGCDFNSYRMGNESFYGSDDLVDTASPFTVVTQFITDDSTDDGTLVEIKRIYIQGDNVIHNSVSNIAGVDASSSITEGFCKQQKTAFGDENSFDARGGLASMGEAFGRGMVLVMSVWDDYAANMLWLDSTYPVDSTRLGAKRGSCDAVSGVPKTVEGAHGDATVKFSAIKFGTLNSTFAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZ09</accession>
    <name>N1PZ09_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase I-specific transcription initiation factor RRN6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_67632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZ09"/>
    <dbReference type="STRING" id="675120.N1PZ09"/>
    <dbReference type="eggNOG" id="ENOG502QRAW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005807_1_0_1"/>
    <dbReference type="OMA" id="DLPMTQV"/>
    <dbReference type="OrthoDB" id="4090074at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001163">
        <property type="term" value="F:RNA polymerase I transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048537">
        <property type="entry name" value="RRN6_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048536">
        <property type="entry name" value="Rrn6_K-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20640">
        <property type="entry name" value="Rrn6_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20639">
        <property type="entry name" value="Rrn6_K-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 beta-propeller" evidence="2">
        <location>
            <begin position="109"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 helical bundle" evidence="4">
        <location>
            <begin position="538"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 K-rich C-terminal" evidence="3">
        <location>
            <begin position="836"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="895"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="936"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME48657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="968" mass="106957" checksum="27235921F6B7DAF9" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZ42</accession>
    <name>N1PZ42_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_123821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZ42"/>
    <dbReference type="STRING" id="675120.N1PZ42"/>
    <dbReference type="eggNOG" id="KOG2633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_3_2_1"/>
    <dbReference type="OMA" id="AKWVIHT"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001664">
        <property type="entry name" value="PRK00431.1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="26"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="208" mass="22408" checksum="0681A73CFD58844E" modified="2013-06-26" version="1">MSITPLSEIPTLTLLYKLKKLSPSSSPSSSATSRFNTRISLIRADITKLETDAIVNAANESLLGGGGVDGAIHRAAGPGLLDECSDLDGCDTGDAKITGAYKLPCKKVIHAVGPVYYSTKRKGMHTTLLQSCYTKSLDLAVENGCKSIAFSALSTGVYGYPSGEAAETAIQAVKKWLEEDESRAENIERVVFCQFMEKDERAYDKYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZ89</accession>
    <name>N1PZ89_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_67413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZ89"/>
    <dbReference type="STRING" id="675120.N1PZ89"/>
    <dbReference type="eggNOG" id="ENOG502RRD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_2_1_1"/>
    <dbReference type="OMA" id="WRNASAY"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40744" checksum="C6E379FF2B2CAB3D" modified="2013-06-26" version="1">MSTVAFIDSIATDRYLQQEDSKDESLAHTIELDDDLSLEDDAQSIAELQARRTSIAEQAKKVIRGVSVGAEEQRDPSYHQDAKAQYYLPNDLPEHVRLEKQAAHLSKVMDDQILHAPVGDASRILDIGCGTGIVTDLMSEAYPEADCIGLDLSTVPHIRPHRSNVRFFQGNVSSQDPTEWTAAAGSALPHDTNLFDYIFSRLLILGISDWPSFIVKELSLLKPGGWAEIQDLAWDYFDQSGAIISSSWQWLEVMNSHLQAKGMDPHCGAKAARWMEEAGFEEVRTFRYVMPFCGESEATMEMREYGKFNCVSVPMMLHHAIPRASGQAEGERVEAMRREMRECLRGGRGTCQAFYVTIGRKPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZB8</accession>
    <name>N1PZB8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_67814</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZB8"/>
    <dbReference type="STRING" id="675120.N1PZB8"/>
    <dbReference type="eggNOG" id="KOG0511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022885_2_0_1"/>
    <dbReference type="OMA" id="EGARCIY"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18497">
        <property type="entry name" value="BACK_ABTB1_BPOZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000248">
        <property type="entry name" value="Ankyrin repeat and BTB/POZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="360"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="572"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME48871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="610" mass="69538" checksum="5546091B4A0F159E" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0G8</accession>
    <name>N1Q0G8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0G8"/>
    <dbReference type="STRING" id="675120.N1Q0G8"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_728743_0_0_1"/>
    <dbReference type="OMA" id="IMPLEKM"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="2">
        <location>
            <begin position="81"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="402" mass="44901" checksum="A8883F96F7C94080" modified="2013-06-26" version="1">MRVNVRVDAWLWDMAVYVLCHAGEVEEAYRIMRLRHDSSEMNLSKSLWSYFLDKASEARHHDATTLAWNSQVKQGYINASSGVCLNVLATAAQAGDAVMATEVFAQLSERGTAFRPIHYELLISTYLSASPPDLNRAISILTIMPLEKMDPTMAETRPLFLYLRDKPALVREALSTLRELHAQDRKIPIAALNLLVECYVEQKDLAEAMKIYKLIHTFVPISQGAQKSFANIDTFNLLLRGCRTADPPDEQQASFLVSELLALRIVPTALTYDRLILVFVAAGKAALEKAAASEDIAVQAERAKGMELLDWAFRHLADMQPLGWMPRFGTLEQLAMNLAKAGDERCWDVLQTSEDQRIDIEGFTEKGKYMRKNVEEAWHAAVDAKQELHIDAGGYAAVAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0M1</accession>
    <name>N1Q0M1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_21871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0M1"/>
    <dbReference type="STRING" id="675120.N1Q0M1"/>
    <dbReference type="eggNOG" id="ENOG502RNPI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_987403_0_0_1"/>
    <dbReference type="OMA" id="CEAFAYQ"/>
    <dbReference type="OrthoDB" id="3647402at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="225"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME48165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="295" mass="32783" checksum="E2352B062FED5A3F" modified="2013-06-26" version="1">MSGESAQVEGAPPHRLRSRKRRALVERQAQASLKHNDAPQPPQKRLRRTQAYSDLEGSSRPRNSPIIPISIHQDDWLEGAVIKARKIINDKENAENFLQRVTAAQSAESLINSLISKRLGVFNLPPRLALSHKNKAQDLRSRYSSPTTAAVGERTSLETLHRKEKTGNLRSKYSSPSSINGEVATPDLLPSVEGSRLSSPSSNDTEELVDSTTSPQSLGDKQQGYLYCTCQRSFDPTLGDMVACDICDGWFHLPCVGQGQHEAAYFEEKSFYCPRCEAFAYQEIVLAEEEVLVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0U6</accession>
    <name>N1Q0U6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_167947</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0U6"/>
    <dbReference type="STRING" id="675120.N1Q0U6"/>
    <dbReference type="eggNOG" id="KOG2542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010245_2_1_1"/>
    <dbReference type="OMA" id="YGPYGWL"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME48250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="629" mass="71761" checksum="24361511A7AE9DD4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1Z3</accession>
    <name>N1Q1Z3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_85095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1Z3"/>
    <dbReference type="STRING" id="675120.N1Q1Z3"/>
    <dbReference type="eggNOG" id="KOG3422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_1_0_1"/>
    <dbReference type="OMA" id="MPGMYEF"/>
    <dbReference type="OrthoDB" id="3639941at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000003">
        <property type="entry name" value="54S ribosomal protein L16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME49781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="232" mass="25766" checksum="3F60123F2F6EAED0" modified="2013-06-26" version="1" fragment="single">MALPIRTAAPTPLLSSVTTRAYCLQSALKALCSQAQSSTRTFSSCRPTLNWLMPKAGESSKSRKGRCHVPTGGSVKGTTLVWGEYGIRLKDHDRRISAAQLKIADETIKKRLRGMKYRLYHRVSANIGVYTSGNDQRMGKGKGSFDHWAARVPVSRILFELKGEVHEQVVRDAMRLAGNKLPGLYEFVRKGDPPVMGITKLENGVTKERLRRPRMAQLNLQTTAERMPASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2K9</accession>
    <name>N1Q2K9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_39998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2K9"/>
    <dbReference type="HOGENOM" id="CLU_2413230_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109831" evidence="1">
        <location>
            <begin position="37"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="92" mass="10153" checksum="CEC6BF1ED70E38D7" modified="2013-06-26" version="1">MSCFHTRGNRPQAVRFTSRFVALRPALLALIDHACAATSTTCRLRARLRRRVLASRPTAQQYLVAASRSICGFVNRDEVVKLGPDGVQCPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2S6</accession>
    <name>N1Q2S6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="4 19">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DOTSEDRAFT_67726</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the ku80 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 19"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2S6"/>
    <dbReference type="STRING" id="675120.N1Q2S6"/>
    <dbReference type="eggNOG" id="KOG2326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010975_1_1_1"/>
    <dbReference type="OMA" id="WAMQYVW"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000008">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000073">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000002">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016570">
        <property type="entry name" value="Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="VWFA" evidence="20">
        <location>
            <begin position="6"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR016570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EME48779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="728" mass="81903" checksum="C64A628CB78C8677" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q310</accession>
    <name>N1Q310_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_84391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q310"/>
    <dbReference type="STRING" id="675120.N1Q310"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_1"/>
    <dbReference type="OMA" id="KAWVHFW"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME48869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="267" mass="29310" checksum="0D80C779389F194C" modified="2013-06-26" version="1">MTFKILDFNTALVTGGAGGIGYAISEYFLSVGKQVIIVGRTESKLKDAASKLGKGTKYYVLDTGDTKSISSFIKKTLADHPDLDCLVNNAGVQRPLDVNEMKPDEFLEKADQEISINISGPMHLTLGLLPHFKSKKGAVIMNVSSVLGYLPSSIINPVYNGTKAWTHFWSMNLRTQLQKDGGSVRVVEIAPPTVSTDLHREREDPDDNKKEKNQAALGVGEFMESITKQWEEDREVVSAGSGQGLTDRWYGEFGEEYGKAAEEFVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3L1</accession>
    <name>N1Q3L1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_67913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3L1"/>
    <dbReference type="eggNOG" id="ENOG502RFXY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101047_0_0_1"/>
    <dbReference type="OMA" id="WAVREIA"/>
    <dbReference type="OrthoDB" id="4502478at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="240" mass="26823" checksum="CFFB3E6C5371FEAF" modified="2013-06-26" version="1">MSKTGKNGCLDRDGCGGQSYPSNKLPIETCMVRRPCQCGRQANTDAGHPPSIRSPETSPSSTALPAIMAPQIPSLAQSESKSKFFERLDLSKDDPADKHLYALMKVEAANGRKRLVESHSSYESINETAMHREILNIYQHACRQTKSTYDQGRDTDGVEEENWIVRWLLWHAFRYRDQRNNRDRRPFDAGEEGAALQSSSNTTTPASSSEPSCTPASRQSEGSASSGRFWDPVRNNWHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q498</accession>
    <name>N1Q498_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_143341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q498"/>
    <dbReference type="STRING" id="675120.N1Q498"/>
    <dbReference type="eggNOG" id="KOG4412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_2_1"/>
    <dbReference type="OMA" id="WAVAYNR"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904855">
        <property type="term" value="F:proteasome regulatory particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="239" mass="25688" checksum="28AAE0C9403CD72F" modified="2013-06-26" version="1">MEDNQQDRFAIHAACREGQTQKVESLLNADKKLATRKDDDDRLPLHWAVSHNRLPIVLLLSDLKSFDVDAKDGAGWTSLMMAASLKDADDVVDLLLAKGADPNETTNNGQTALHFAASKSLLDTARKLFAHKASARVSDKRRQLPLHRAAAVGSVPIVKLLLDNRSPINATDIDGSTALHHAIAEGHGDTALALLKAGAEHDKVDGRGNLAIHLAPDIGVRSYILRAAEEEGIELAVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4J1</accession>
    <name>N1Q4J1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4J1"/>
    <dbReference type="STRING" id="675120.N1Q4J1"/>
    <dbReference type="eggNOG" id="ENOG502QSAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040959_2_1_1"/>
    <dbReference type="OMA" id="ETYMTDL"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="400" mass="44278" checksum="20014489C563AF71" modified="2013-06-26" version="1">MARNRHGKSGANRQAMAASSLEQLYALALDHVEQSQPAEALVVAKQLWGLVKDRPSAIQKLPALNLLGDISIELGAVDSARGYFELAVRLDPEGQVPEALGGGAEKFLWLAQLCDEGGKQSVEWFEKGVQALQTEIAAIEGGGITGLSEEQLLLMRVEKKRKLANALCGIVEVYMTDLSWEGDAEARCESLVTQAMTVEDETSPEVLQTLASVRLSQERKEDAQSALKRSLETWIELESEDEAVPDFPTKISLARLLMEADLLDQAMQVCHRLIQEDDQSVEAWYLGGWCQYLLAQHNKADNDLANDSAMDTGAGDQSAAVYHRALKGSRRWLKMSTKLYERQQYEDDRLFEHAEELVAGLDTVLGPEDEQAEGGVEDDEDEWEGIEDDHAGEDEEMQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4V8</accession>
    <name>N1Q4V8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_68516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4V8"/>
    <dbReference type="STRING" id="675120.N1Q4V8"/>
    <dbReference type="eggNOG" id="KOG2710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004568_2_0_1"/>
    <dbReference type="OMA" id="REHRRSW"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04396">
        <property type="entry name" value="RhoGAP_fSAC7_BAG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="73"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="735"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME49759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="849" mass="91482" checksum="1D2E774902FAF41A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q560</accession>
    <name>N1Q560_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_20556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q560"/>
    <dbReference type="STRING" id="675120.N1Q560"/>
    <dbReference type="HOGENOM" id="CLU_1133565_0_0_1"/>
    <dbReference type="OrthoDB" id="3649769at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="70"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="245" mass="26523" checksum="BEF521A74F114A10" modified="2013-06-26" version="1">MTICAQGHSAKCGRWQALETRNDSERYSQTLSPKTDLHTLPAIRLITVLSKCIEALGSASGGATDAGPAYAALSYIWGNDQQVKLRKGNASSLSQPGSIGRKPPSQSVVDAIEIVSRLDVGIQYRWVDALCIVQDSDEDKALQISRMGRTYTAAEFTVVVATGEDADAGLPGLREGTRNVTQSVVAVVPLGTHRYSDKGLKYHQHGLAITDTLSPLWNEDHDFWTTETTPPEDGLCKKGFYLDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2WHG0</accession>
    <name>M2WHG0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_75999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446549">
        <property type="protein sequence ID" value="EME38027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WHG0"/>
    <dbReference type="STRING" id="675120.M2WHG0"/>
    <dbReference type="eggNOG" id="KOG1505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1372190_0_0_1"/>
    <dbReference type="OMA" id="CMYDITI"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF24">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 3, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase C-terminal" evidence="5">
        <location>
            <begin position="149"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME38027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="199" mass="23537" checksum="CA7E210384517FEB" modified="2013-05-01" version="1">MLGRCRYFAKSQLKWVPFLGWGLWAMGMPLVSRKWTRDQREMERVFRGILRRRWPVWLVSYSEATRFTAAKRAAAEKWCQANNKPLGKHVLYPRTKGFVACVQKLRRAAHVKAVYDVTIAYAKDGRVFQAAPTFVQTLARPHLDQDWTFYVHVDRYELSELPTEDEQLVQWLESRWLDKGGRLEQLNQRLLKNEPWGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2WI85</accession>
    <name>M2WI85_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc-binding ribosomal protein S27e-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps27e</name>
        <name evidence="6" type="ORF">DOTSEDRAFT_75462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WI85"/>
    <dbReference type="STRING" id="675120.M2WI85"/>
    <dbReference type="eggNOG" id="KOG1779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130128_3_0_1"/>
    <dbReference type="OMA" id="CASILCQ"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME38718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="82" mass="8859" checksum="85502B560FC27FF6" modified="2013-05-01" version="1">MVLAQDLLNPSPEAEASKHKLKTLIPGPRSFFMDVKCPGCFTITTVYSHAQTVVTCAGCSQVLCQPTGGKARLTEGCSFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJR6</accession>
    <name>M2WJR6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial presequence protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_75067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJR6"/>
    <dbReference type="STRING" id="675120.M2WJR6"/>
    <dbReference type="eggNOG" id="KOG0961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006065_0_0_1"/>
    <dbReference type="OMA" id="WEGFARI"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="2">
        <location>
            <begin position="57"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="199"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME39208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1045" mass="117215" checksum="CB24C57464DDDCD6" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2WLW7</accession>
    <name>M2WLW7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_25026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WLW7"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="OMA" id="TATITFM"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000670">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF81">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME43038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="533" mass="57611" checksum="A5F1DC188027DF62" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2XIV2</accession>
    <name>M2XIV2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_107276</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XIV2"/>
    <dbReference type="STRING" id="675120.M2XIV2"/>
    <dbReference type="eggNOG" id="ENOG502SFDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2475052_0_0_1"/>
    <dbReference type="OMA" id="KCICTNT"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CFEM" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME39382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="74" mass="7442" checksum="9BB6F9FD2F706880" modified="2013-05-01" version="1" fragment="single">IPGLPSCAQSCITNYGGCNQVDVKCICTNTSLLETLSCCVSQKCDAAGTAAVIKFADSLCGSFGVTTLPTAATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKB7</accession>
    <name>M2XKB7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_24932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKB7"/>
    <dbReference type="HOGENOM" id="CLU_2333594_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="98" mass="10637" checksum="30926B362EC119CE" modified="2013-05-01" version="1">MGPFITPEPERIVATPISAPDTTLTFTSLVVPSQSRLSTKTYLGQQDLDGYLPEQRSARRVILLALFFGSSALCSIFISLGTPLRLTPLVNSFARPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKM1</accession>
    <name>M2XKM1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal eL28/Mak16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_35388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKM1"/>
    <dbReference type="STRING" id="675120.M2XKM1"/>
    <dbReference type="eggNOG" id="KOG3412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106801_0_0_1"/>
    <dbReference type="OMA" id="GKYGQRP"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000002">
        <property type="entry name" value="60S ribosomal protein L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME43047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="153" mass="16816" checksum="33BBDB4286DE91F4" modified="2013-05-01" version="1">MATGGENISNDLIWEITRGNNAFLVKRKQAGGVQFSRDPLNLVNKHSRKYEGYVNAQAIGIQPDSNTIALTTKTKSANKPAQLYQTSSFNASTPTRKLYKSVVNSTAKKGYRSDLRAEAVARASAVRSSQREKKDRAEPKLRGAKARKAEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2XM07</accession>
    <name>M2XM07_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_72752</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.M2XM07"/>
    <dbReference type="eggNOG" id="KOG0779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_252931_0_0_1"/>
    <dbReference type="OMA" id="ISENLHW"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="822"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="456"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="936"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1165"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1280"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1385"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="981"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1204"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1218"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1413"/>
            <end position="1423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME43477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1423" mass="157187" checksum="2FDF7F9361D0CE39" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y2C1</accession>
    <name>M2Y2C1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 34 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gal1</name>
        <name evidence="5" type="ORF">DOTSEDRAFT_75204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y2C1"/>
    <dbReference type="STRING" id="675120.M2Y2C1"/>
    <dbReference type="eggNOG" id="ENOG502SJI7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_401709_0_0_1"/>
    <dbReference type="OMA" id="HHAVKGK"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 34 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="685" mass="75919" checksum="CA880C184076FE1A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y2U1</accession>
    <name>M2Y2U1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_159992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y2U1"/>
    <dbReference type="eggNOG" id="ENOG502S8KK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131496_9_2_1"/>
    <dbReference type="OMA" id="IVMIETY"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624:SF1">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="114" mass="13063" checksum="29E71E1FF8F8EDB4" modified="2013-05-01" version="1">MSEVHIIAIIHPTPGKVDRLVSLLKNMCKDVHEKEDYTLRYIATEQIGPEKPTTPDIVMIETYKDKDSADKHTTEPHFKKLFATFDEEGLMANPPYLAQTKSISGFDLDRKFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y361</accession>
    <name>M2Y361_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4 9">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_75389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4 9"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y361"/>
    <dbReference type="STRING" id="675120.M2Y361"/>
    <dbReference type="eggNOG" id="KOG3143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044308_3_0_1"/>
    <dbReference type="OMA" id="GIPFFDH"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000005">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME39724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="225" mass="24383" checksum="982231B5E797B377" modified="2013-05-01" version="1">MSSEKRIRSAQIARDTNETKIQLSLNLDGGFLEEMHSDGKTNGEGHASQASKSQTIAVDTGIGFLDHMLHALAKHGGWSLRLRTRGDLHIDDHHTAEDTCIALGQAFKQALGTITGLARFGYAYVPLDEALSRAVVDLSNRPYSVIDLGTKREKIGDLSCEMLPHCLESFALHAGITMHIDCLRGANDHHRAESAFKALAVALRMAISPVAGREGEVPSTKGVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M2YI30</accession>
    <name>M2YI30_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_39711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YI30"/>
    <dbReference type="HOGENOM" id="CLU_940172_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="296" mass="32807" checksum="09E87588F42E40AB" modified="2013-05-01" version="1">MADHLDASKGSRHATKACDKCALLCVWAMVKQAWMYWPHASRVRSQRIAADAPDIFCSRASKRSHTDVSQWSLIAPICYSVRLAMSISGIVAGKPKNHYGSTSANETIYAATGNSSCKIIDRREDATMRSRLPWRQRQVSSHNAFPSPERDEDLLKWYNSNALKATKPSLAYSADSTTYVPVQCRSVMLSERISRMRKLKPASRACRKQALSSSGMSTFVQVYSSTTTRSVGHVEALRERRSVFFLSTAWLQIQTVFGIVITDHAISTDHPLVTCQSTAQISPTGVASGSCYSDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJ39</accession>
    <name>M2YJ39_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 18">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16 18">1.3.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">C-24(28) sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol Delta(24(28))-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DOTSEDRAFT_75582</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15 18">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16 18"/>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJ39"/>
    <dbReference type="STRING" id="675120.M2YJ39"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015631_3_1_1"/>
    <dbReference type="OMA" id="QLPYFCN"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EME38921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="540" mass="62401" checksum="E28796B13E9934CB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2YK44</accession>
    <name>M2YK44_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MPR-like GPCR protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_75103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YK44"/>
    <dbReference type="STRING" id="675120.M2YK44"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029962_0_0_1"/>
    <dbReference type="OMA" id="SRWTYIL"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="122"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME39265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="56987" checksum="1120D5DF00845166" modified="2013-05-01" version="1">MSTYTTMTTCTKTFTDTREEPTVGASSGAEIDHEIERARKRRRHSSYNPRSWSLERENAQIVVENFLNDLGKRLEMLETYGSLKFDEGVKSVHDTLHHVHERCAQVSDDIIDAGRRRRKVFVETLESHYRDALVRKDTLEQKVQEGVKVMEANLVALEQRAYKMRERGLTATAHELMDSGIAYMESTATTAAEIVHEGADAARRAKDKMKLKVEIALAHARKHGLVTYDMLPEPWRVNPHILSGYRFSETKLDCVRSCFTMSNEFFNIWSHAIGLVIVLAIAFYFYPNTPAFTSATYFDIVIAGCFFFAACKCLVCSCMWHAMSSISDQNLMERFACVDYTGISLLVAASIMTTEYTAFYCEPWSRWTWISMTFALGIAGVILPWHPTFNRADMAWARVGFYVTLATTGFLPVFQLTYERGLGETFYFYAPIVKSIAVYLGGAVMYAAKIPERFLPGWFDYAGGSHNIWHLAVLGGILFHYSAMQSFFGEAFRRANVGCSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKD5</accession>
    <name>M2YKD5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_56819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKD5"/>
    <dbReference type="STRING" id="675120.M2YKD5"/>
    <dbReference type="eggNOG" id="ENOG502TA53">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1835122_0_0_1"/>
    <dbReference type="OrthoDB" id="3639531at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16182" checksum="114D8D91C24106F2" modified="2013-05-01" version="1">MGDPDPPEPPRDDTTTGYVAKASRLLSLPQELQDIIFAFAFPAHESLDFLTHSQWESREKETRRKNTDHVLRPFPAPKVDDFFVCKQYFACAARAWVTNQHFTNDSGQAFHDIDRNCGVRATEIIRPNVTKLTLNYWLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKX7</accession>
    <name>M2YKX7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Manganese/iron superoxide dismutase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_56874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKX7"/>
    <dbReference type="STRING" id="675120.M2YKX7"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057349_1_0_1"/>
    <dbReference type="OMA" id="MTAREPN"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="200"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="318"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="377" mass="42184" checksum="EC0EBAFA77E1C224" modified="2013-05-01" version="1">MKPKKWVGEKARRRTVDAKQAFLSAAHVVPNRGSLESPRSQCTSLWMMSTRNYRAYTSTTMITRRLARPLASLASSQWTCPSCRTSIIRQTQRPSQIRSLHRVPLIAYHEAFSEKGVDNLFSRQGYEIAWDQYQTHLVQKINELTAGEPIENTPVKDIAIQFARDPMNASLFNYASAAHNNQHFFSTLAPAPLKLGDCPQLQESLVKTFGSIETLRMTMLDTAAAMFGPGFVWLVWARNVDGTRGFNGRGGSWRILTTYLAGTPYPEAGYRAQGLDMATNNQSSYNAYLQGMPANTAGSFGAFSQSGKEQAKIPPGGTSVMPVLSVSTWEHTYIYDYGITGKRNYLDKWWNAVDWGVVEQNAPMEAKQIGIGFQRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M2YL67</accession>
    <name>M2YL67_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinesin-like protein KIP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_180388</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for assembly of the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YL67"/>
    <dbReference type="STRING" id="675120.M2YL67"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_24_0_1"/>
    <dbReference type="OMA" id="YYDNVFT"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000073">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="16">
        <location>
            <begin position="241"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="639"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="863"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="951"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="832"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="644"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="877"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="909"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="322"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME39701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1049" mass="114926" checksum="0F2E1252CF79E452" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2YL84</accession>
    <name>M2YL84_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">eno1</name>
        <name evidence="17" type="ORF">DOTSEDRAFT_75320</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YL84"/>
    <dbReference type="STRING" id="675120.M2YL84"/>
    <dbReference type="eggNOG" id="KOG2670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_0_0_1"/>
    <dbReference type="OMA" id="RCMMSHR"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="16">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="15">
        <location>
            <begin position="143"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="374"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME39630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="438" mass="47346" checksum="85F5EC6C17AECC76" modified="2013-05-01" version="1">MGISKIHARSVYDSRGNPTVEVDIVTETGLHRAIVPSGASTGSHEACELRDGDKSKWGGKGVTKAVANVNEKIAPELIKANIDVKDQSAVDNFLNKLDGTQNKTELGANAILGVSMAVAKAAAAEKKVPLYAHISDLAGTKKPFVLPVPFMNVLNGGSHAGGRLAFQEFMIVPSEAPTFSEAMRQGSEVYQKLKSLAKKKYGQSAGNVGDEGGVAPDIQTAEEALELITESIKSAGYEGKIKIAMDVASSEFYKSEEKKYDLDFKNPDSDKSKWITYEQLAQQYRDLAAKYPIVSIEDPFAEDDWEAWSYFYKNSDFQIVGDDLTVTNPTFIKKAIDTKACNALLLKVNQIGTISEAIQAAKDAYGAGWAVMVSHRSGETEDVTIADIAVGLRSGEIKTGAPARSERLAKLNQILRIEEELGKDAVYAGAQFRNAVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2YM80</accession>
    <name>M2YM80_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidylpeptidase IV N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_153255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TolB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YM80"/>
    <dbReference type="STRING" id="675120.M2YM80"/>
    <dbReference type="eggNOG" id="ENOG502QPTW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011452_0_0_1"/>
    <dbReference type="OMA" id="MPLYVPN"/>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36842:SF1">
        <property type="entry name" value="PROTEIN TOLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36842">
        <property type="entry name" value="PROTEIN TOLB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="66698" checksum="F4F58D5030C92A37" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC87</accession>
    <name>N1PC87_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_178640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC87"/>
    <dbReference type="STRING" id="675120.N1PC87"/>
    <dbReference type="eggNOG" id="KOG2406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006241_2_0_1"/>
    <dbReference type="OMA" id="TKDYIWQ"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="620" mass="69692" checksum="8987B13EF3484016" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCH7</accession>
    <name>N1PCH7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_74739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCH7"/>
    <dbReference type="STRING" id="675120.N1PCH7"/>
    <dbReference type="eggNOG" id="ENOG502QWTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008241_2_0_1"/>
    <dbReference type="OMA" id="YNTDILC"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="651"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="703"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME39977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="820" mass="91011" checksum="6EF00E710F58ADFC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCI2</accession>
    <name>N1PCI2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCI2"/>
    <dbReference type="STRING" id="675120.N1PCI2"/>
    <dbReference type="eggNOG" id="ENOG502SKX3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_3_1_1"/>
    <dbReference type="OMA" id="WDIVEDY"/>
    <dbReference type="OrthoDB" id="5386922at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="57"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="522" mass="59190" checksum="C1623F886CEFC211" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCQ5</accession>
    <name>N1PCQ5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCQ5"/>
    <dbReference type="HOGENOM" id="CLU_2306011_0_0_1"/>
    <dbReference type="OrthoDB" id="3650371at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="100" mass="11007" checksum="E35BD987758E6502" modified="2013-06-26" version="1">MSTFMCNIICLSRFACDRPSAQAFTCLSLRRFRPPVCRSRHSIIFSRQPMTKDHYALPGRAPPNCSISCSSVSVCKPDSRTASARGRNASASCRGPMHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCV8</accession>
    <name>N1PCV8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_37246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCV8"/>
    <dbReference type="HOGENOM" id="CLU_1366233_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="200" mass="22107" checksum="A4328F0C31F2D73F" modified="2013-06-26" version="1">MSTPEPFCSMCGQTGHTYTKKDDEKEMKAQGAAMRRNVEQKMKAALINAADEATALGAHYSALNAFRTLEVSGPAKATDLMSKAPETNDTSKLSRSKRKKLAKTVERKPQTILELFKAEGSDQLPGWAEVFGDAVPQNAEAKRRFTTGVNNVYKGRAGLVKDGLLHQKLIERSINPKEHGMKFADEMDEEMEEADENSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD79</accession>
    <name>N1PD79_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_28194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD79"/>
    <dbReference type="HOGENOM" id="CLU_1034475_0_0_1"/>
    <dbReference type="OrthoDB" id="10565628at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="269" mass="29918" checksum="06916FE083A88659" modified="2013-06-26" version="1">MSDLVSGSPLPCRDWRVPRTQLVLSLSTTAASYMSWVDAVNGAQKDHCLSYSRVLEPMGWLLGSLTTGERPFAVIQWTSSIIDTLRSLQIAKKTARSQDHLQTLLRRGQYNCINSAPNRLDTPPAPQYPHPLDINNSTKRLSIITATLVQNRARRFLLLACEAFRDGADDRSNAQVYSLASDLFGAALRQRGVEECVAEADDAVKELRCDEGKGYLVEAWGVLMGDGHNNDAENIFELGMRLYGAVEREKRVEGWGESQDENNEDSASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDB1</accession>
    <name>N1PDB1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_74965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDB1"/>
    <dbReference type="STRING" id="675120.N1PDB1"/>
    <dbReference type="eggNOG" id="ENOG502RZZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026180_1_0_1"/>
    <dbReference type="OMA" id="CNPRTHS"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="3">
        <location>
            <begin position="185"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="490" mass="54584" checksum="CDAF41A5119CF544" modified="2013-06-26" version="1">MPLNAKSSALAHTGQNALLIALSLFFLPLDVTVLLLSYIVRPFWRTSYQLEALHHADDQKTVLVTGVGMTKGLVLARAFSRAGHKVVGADFEPNGALVPGRVSNSLAGFYRLQKPDASRGSVPYIQGLLDVILKEKVDLWVSCSGVASAVEDGEAKEVIENRTDCRAIQFDVATTQTLHEKHTFIDHTQELGLTVPETHTITCRKAVDNALEKATPGRKFIMKPIGMDDSARGDMTLFPLKTQQETSRHLDRLKISEKSAWILQQFVQGSEYCTHAVIIKGKVKVFVACPSAELLMHYEALNPASALSRAMLKFTEEYAEQGGPGFTGHCSFDFLIEDTSPRDPSQIVLYPIECNPRAHTAVALFNGTPAMVDAYLSLLDDSVNGSQTSKVVIPAREDKYFWIGHDLVTRFVQPLARLVLLQSSAQDFGRAVRGFVLHLLSWRDGTFDVQDPLPWFYLYHVYWPMQFFACITSGKRWSRINVSTLKMFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDP4</accession>
    <name>N1PDP4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DOTSEDRAFT_75915</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDP4"/>
    <dbReference type="STRING" id="675120.N1PDP4"/>
    <dbReference type="eggNOG" id="ENOG502SG7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138063_0_0_1"/>
    <dbReference type="OMA" id="QAINMAS"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EME38559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="154" mass="16720" checksum="E4D380E661D24912" modified="2013-06-26" version="1">MSYKDHPKSRQTILPSQMVRDGATASIRSGSGLGHSNNHQSALQARVNEKRLELESLKQLRDLSAGLAGQMQQLEEKLSTLSDGTEAVAAVMGNWNTVLRAVYMASQAIPKSRAAEDQAGEQKEDALPQTLVRIPIQQAEAVQREQAEKEANAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE07</accession>
    <name>N1PE07_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_37594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE07"/>
    <dbReference type="STRING" id="675120.N1PE07"/>
    <dbReference type="eggNOG" id="ENOG502RM6T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_312834_0_0_1"/>
    <dbReference type="OMA" id="WPGTQAM"/>
    <dbReference type="OrthoDB" id="5419922at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="937" mass="100964" checksum="FD6917D2722C1285" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEI6</accession>
    <name>N1PEI6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_74545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEI6"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_8_0_1"/>
    <dbReference type="OMA" id="EPLNWAG"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME41043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="544" mass="62637" checksum="C2137997A13ABD42" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEK4</accession>
    <name>N1PEK4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEK4"/>
    <dbReference type="HOGENOM" id="CLU_2306013_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="100" mass="11485" checksum="2410180A7855189C" modified="2013-06-26" version="1">MRFQIDQVSGHPSLKPGRLHEGSRDLLAFRRLCLARLSIPRRNRSLLSQQPHAKIGRFLGILSLRLGGERLLVDGGWQTGWVREGLCEELSRLSLMERER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEQ2</accession>
    <name>N1PEQ2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEQ2"/>
    <dbReference type="HOGENOM" id="CLU_1562850_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="171" mass="19287" checksum="1AC04742FF8BCC30" modified="2013-06-26" version="1">MKWLVPSHYHTWSLVPGPCKAQTHWQLRAGRRGQGSVIRESNRCPATWKPCVPCSFCNNTTARGSKTAVTEPLQQKSHVDRGRETDPGEDVYGQLSSFHHALNRDRTSHCAARSGSDMIKPGTTLERPFVSNICLPTAILVLSIVAFFFYLLLYEMVSRRVRSVSRPRHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PER7</accession>
    <name>N1PER7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PER7"/>
    <dbReference type="HOGENOM" id="CLU_2108963_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="115" mass="13018" checksum="4C0553106F56960D" modified="2013-06-26" version="1">MDLKNAALLRHIRGQGTEALGKFDKVPADVRSEVNSQRWKASESTEPAWAIKRPPKERVADGRFRAPVLDLRRSDLIMWAEADDDIVYASQSDRHAVASYNTEGQDSLRLIRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF21</accession>
    <name>N1PF21_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_37943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF21"/>
    <dbReference type="HOGENOM" id="CLU_821416_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="338" mass="37322" checksum="6BE55D4A05A636F5" modified="2013-06-26" version="1">MGRARLLGAHLGRALVPGGGSFHSAGAARLPAVIEDGACKVHDASDKKTLECARVHSFCVDKGSGNRPRGYRDVGLARDRPVRQVQHHLPPPRRLPESERIVLSVLRDVVRTGLASFLPCKSSDASILIAADESGRNHVQVTVAAGTSKTWACLMMQGRRGGAQYCPVLRHCLISTSGLLWLVPTRSGRIFAESTRSRSTWQQAAVIPRCSLWALGDRRSSFLALRSESPKSTGSCPRTIPYSSRDNLRMDHYKNLRNPHMAATLSSRMIPGAHVHPNRTSVQLSLRSQHTQILWWPAAKWHILQHPIGGDFIRNVCFLLQGRRRYSLETPGVYGCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFN4</accession>
    <name>N1PFN4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_38352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFN4"/>
    <dbReference type="STRING" id="675120.N1PFN4"/>
    <dbReference type="HOGENOM" id="CLU_1085964_0_0_1"/>
    <dbReference type="OrthoDB" id="5431474at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="256" mass="27623" checksum="5E21B5E5DFE67110" modified="2013-06-26" version="1">MSRKPLPLHFDSDLELRLRSDSRANDTIALHDAAIKSATSLMAVMNACLKSPQLNAHLLAAQQQSAGLKPVSGRPRSHTAPSTSLVEAPCKEPAELEGSTPLWSQPASQPSLHVDGSQHAAALGNSILRPHSSPQQVSYRMPVHPQHDDGRTTRNTGLPEGSARVSELHRSNTRIEGRTSAAVNLSGETLVPQNYDHGSEAPDKSIVSTRPDWFGSSRDRLPSVDANPQSEASQPSVYAPQRRDAISEAHSRPMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFT8</accession>
    <name>N1PFT8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFT8"/>
    <dbReference type="STRING" id="675120.N1PFT8"/>
    <dbReference type="eggNOG" id="KOG3699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="OMA" id="CCHVQLL"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF41">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="54"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="290" mass="32045" checksum="363E91F9F337D7B6" modified="2013-06-26" version="1">MAPISTFDIPAPDTIPKDGLKIKFEQKEGQEIGFVDTPQLSFKNKHEEREYIRGRLAGAYRIFGHYGLNEGLAGHITVRDPVEPDTFWVNPLGVDFNLINKSDLLRVDHKGNILDHGRVKVLNRAAFLIHGAIHEARPDVLCAAHTHSVYGRAFCALGKPLETISLESCFFYEDHVVFEGKGVVLDEDEGLDIARALGNKKAALLRNHGLLTVGQTIEEAINWFYMLDKCCHVQLLADAAAAGRGGETAKITHEEAEYTRGVAGHPKAGWMGGNAMFEVIDEKTGLSYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG22</accession>
    <name>N1PG22_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TATA-box binding-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tbp1</name>
        <name evidence="7" type="ORF">DOTSEDRAFT_46328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG22"/>
    <dbReference type="STRING" id="675120.N1PG22"/>
    <dbReference type="eggNOG" id="KOG3302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060161_1_0_1"/>
    <dbReference type="OMA" id="NCEYEPE"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME41317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="254" mass="27832" checksum="26919A634A61650E" modified="2013-06-26" version="1">MDTMMYTPQNAAEAKAFTAPNSLSYGNVPPSQLTPPSENGSQTQKPAAPNGPPQQQGVVTPAATPATAQANTGVSGIVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDIKFPIRLEGLASRHHMFSSYEPELFPGLIYRMMKPKIVLLIFVSGKIVLTGAKVREEIYQAFELIYPVLSDFRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGE2</accession>
    <name>N1PGE2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MAPEG family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_74233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGE2"/>
    <dbReference type="eggNOG" id="ENOG502S7P4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110778_0_1_1"/>
    <dbReference type="OMA" id="RTGVWAW"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME40615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17628" checksum="30B4D52238BBB2F3" modified="2013-06-26" version="1">MATVSFSIPILSIPLYYVLAVFPHGYAITKASRGDLKKHDNRNPKGSAQLENIKKRLSPKEFAAFERGESCHRNHLENMPLYVATVFAGILAESRVGEGELGLINFVVGWMAIRTLYTVNYLATEQSQGWTQVRSLLYFLGTGWSFLILWRSAFALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGL0</accession>
    <name>N1PGL0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 92 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_177476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGL0"/>
    <dbReference type="STRING" id="675120.N1PGL0"/>
    <dbReference type="eggNOG" id="ENOG502QR5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_4_1_1"/>
    <dbReference type="OMA" id="TMVNPQN"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF25">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108792" evidence="1">
        <location>
            <begin position="17"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="270"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="777" mass="85923" checksum="9E380A9FD8FBC654" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGY8</accession>
    <name>N1PGY8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_26574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGY8"/>
    <dbReference type="HOGENOM" id="CLU_894359_0_0_1"/>
    <dbReference type="OMA" id="FTDHQIH"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME41399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34043" checksum="FF430DBC7ABDCD45" modified="2013-06-26" version="1">MDSATKQSKTLDAPSPSKTPQKKRRNNSPDRKNTAQTSNLEDTLIKGASHHAQATNKFIVSPKKKNPQNQISPVKAPPGREGSAGQRPVLSRAYTSPIKQRRNSQGQIICVFWPQGRCVYGESCLFVHERDRNGEPASLESQARHRGEDQSAKPAARPVRSELLSCCTCGATGHYRGECPSTSASASSDAATSQLNAEVSKILAENSSISLADEDTFFESLEQTNSQAFTDHQIHGKLTDSTIRRLLVHAYAVRQASQDAMKFACQSCQTDDYEKADALDELAKEILNTPGLPFDQKTKERIVEAVARPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH35</accession>
    <name>N1PH35_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH35"/>
    <dbReference type="eggNOG" id="ENOG502SF0B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107878_0_0_1"/>
    <dbReference type="OMA" id="NSRAKWA"/>
    <dbReference type="OrthoDB" id="5153521at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="195" mass="20932" checksum="BC5370AA693127EE" modified="2013-06-26" version="1">MSAEQSFSQADLRATQQDYKRDATRKHKWALGPTSGVGRAEGKPRPLRSAATAYNQKRREEKGAAVASLAHGAKVNRKHDMLEGAALTDDSSAASSSDRDTPSPLPADVGITYSFDAARGPSKGSQILNAALAKAVETFQEKETVQLVKSEYELLDSDGETMKAASKKGKKNKARSSASQEAVIVPDADEDYEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHM6</accession>
    <name>N1PHM6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHM6"/>
    <dbReference type="HOGENOM" id="CLU_2867629_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="64" mass="6849" checksum="2807389BBA208A20" modified="2013-06-26" version="1">MTRSECCVRYMSTCNGMCKISTGPSVDVTQAKPVWAILLKDKDEVPLPAAVRSCGFRVGVVSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHW5</accession>
    <name>N1PHW5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4 7">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_135803</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="4 7"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHW5"/>
    <dbReference type="STRING" id="675120.N1PHW5"/>
    <dbReference type="eggNOG" id="ENOG502QTQG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_5_0_1"/>
    <dbReference type="OMA" id="QDIWAPS"/>
    <dbReference type="OrthoDB" id="195678at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109857" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="9">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME41694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="346" mass="37160" checksum="B7941427D344AE53" modified="2013-06-26" version="1">MASILVQALLLSPILTAASPLVKRDYPAVAVGACSGTCRGRLHDPAVIYREDTSTYYRFTTNDGLHTATAPSISGPWTDEGPALPDGSIIDLPGNKDLWSPDVFHYHNTYYLYYAVSEIGSVTSDIGVATSPSLAPGSWTDHGSVGIPSSTSSYNRIDPNLYFPSGGSPVLNFGSFWQDIFQLPMEASLLSVANLAAPTHIAQNTTTRPVGLAAGSQEGAYEFRWGGYTYLFLSSGNAFNQPGVGSGLAPPGEEYHILVCRSTQESAGFVDQEGRDCLTQSGGTLLLGSHGDCYAPGGQGVMYDPKLKSPVIYYHYVKPSVSYAYDDFFFGWNKLDFEGGWPRVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI72</accession>
    <name>N1PI72_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MAPEG family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_81082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PI72"/>
    <dbReference type="STRING" id="675120.N1PI72"/>
    <dbReference type="eggNOG" id="ENOG502SRDN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129387_0_0_1"/>
    <dbReference type="OMA" id="IQAIAHN"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME42087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16257" checksum="BFFECFB0678190C4" modified="2013-06-26" version="1">MSTNLGLGLNPLLKPVTVLAGWTFAMQAWMHVTRINAIGTYNVSIEPGKINQELEQKVPNNIQAIAHNYNHLHEQPTVFYAVALALAMAGDTHQYTLSAAWTYVGIRIFHSLYQVFVNKVLTRFQIFLSSSVVVAGLTGRLATIVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI84</accession>
    <name>N1PI84_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_155021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PI84"/>
    <dbReference type="STRING" id="675120.N1PI84"/>
    <dbReference type="eggNOG" id="ENOG502SNH8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015711_1_0_1"/>
    <dbReference type="OMA" id="TQWNVAT"/>
    <dbReference type="OrthoDB" id="5426191at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="500" mass="54800" checksum="6635A60774860575" modified="2013-06-26" version="1">MTYDMDTVVEATSLSQVTEIATNPPAHPNAPTDYPRLPLVLYIARVPGSRDVFLTPIKPREKVVTAEDVQSSLYYIHVNCQEDYEEKPALPARPQAPLTPPYPVDDFSHGQQRHKGSPKPKQIARKPIGSKSDSGPPVPQHGLGSVQSEGQRRPLPSPPAEEQPMTSTTLHADNVRLLRCAEHSDDVNPYERRYGPAPGIIDPATLPDPGSLTVIRRDPASNEQWNVASIHDPPVQEVSSASLRNPSATQRTKRGGAPLYLDISNPSYVQFDNHERTGSRISTASSTSSDSDPPLEGIFRRRLYMPGSQYGEHQYGHSRFGSTGSSLGEDLPIRRTMRGSVDMSLSFSSPSYDRQKAYTFTCPWDGRCEFSAGATGRSLKCRHQLPISHGGNTADVSELRFNLPTAQKNAASVLSDKRSSYFHRLHGRAQSSEDGNNTPSFIISDDGKLDLTLGQEKAGGGFGGKQAKLGKLIIEPEGLKMLDLLVAANVGLWWRAYEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIG9</accession>
    <name>N1PIG9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_156135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIG9"/>
    <dbReference type="STRING" id="675120.N1PIG9"/>
    <dbReference type="eggNOG" id="ENOG502QSK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036208_0_0_1"/>
    <dbReference type="OMA" id="KWALLWR"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="61601" checksum="651941E2CF665250" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIW0</accession>
    <name>N1PIW0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_46279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIW0"/>
    <dbReference type="STRING" id="675120.N1PIW0"/>
    <dbReference type="HOGENOM" id="CLU_1492510_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="181" mass="19560" checksum="3FB5FCD857E3D8D3" modified="2013-06-26" version="1" fragment="single">LLDDKNPPPTYNAQPHNRALPSLHSDSDAEASMVSPLSAGANVNDPASGSGQLVIAIDHGTTFTGVTFTTTHSEHADLAKISVLMDWTPKVSNQQKFRSVISCASPTQEWDSDISEDAVTTVRTKLELEHRNTRLAEVNLTLRILRGSGCLGLEHIRKSGPSPAFATRTPVQTVTDYLTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJP7</accession>
    <name>N1PJP7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_73983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJP7"/>
    <dbReference type="STRING" id="675120.N1PJP7"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005350_3_2_1"/>
    <dbReference type="OMA" id="ETFHILL"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="491"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="831" mass="91433" checksum="0E3C28714334BF4B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJY9</accession>
    <name>N1PJY9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_23957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJY9"/>
    <dbReference type="HOGENOM" id="CLU_1555219_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109901" evidence="1">
        <location>
            <begin position="17"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="172" mass="17377" checksum="2EDD6F1BA56CEC25" modified="2013-06-26" version="1">MQYTLAALALAAMASAIPAPAPQITPSPKLDERQLGVFPISASGSLVGGVGPVPISIPIDSLKLYPSSVLDVCLGGVCLPEITTAPKPREVEERALPGVGGIVTLSGGQDGTIGLASGSFGPIIDPTAIKFCDKGSYDGANSYANCPIEVPLTLPARDAAPEATAAAITYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK94</accession>
    <name>N1PK94_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_129302</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK94"/>
    <dbReference type="STRING" id="675120.N1PK94"/>
    <dbReference type="eggNOG" id="KOG3134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057366_0_0_1"/>
    <dbReference type="OMA" id="MLDMNVK"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME43756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="300" mass="32975" checksum="1476396BF6D17EA9" modified="2013-06-26" version="1">MPICIECRYPVSNLYTTYSKADDKASGRGVRLTQCPRCKRFADKYVEHDFVVLFIDLVLIKPQVYRHLLFNRLGREDDKFDPSIIRLGILLLLFDVYLTWARIEKATPTSPSLPLSPPPPLPPFPSGSNTTIPRTLNPNNGHSSFLATQPILLQYLFFLFLCTLETASFHLPVKFLLSLKLPLIPHYPHAALISTALLVSSFTKLFPLMLLVWKYDLPSSASAVSWAVIINNVAALEILLDCGYVRAALLAAVGAVCRAGVGWGILRAVGVGGGVAAAGVVETGDLIDVWRRLMETVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKF5</accession>
    <name>N1PKF5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_73984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKF5"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OMA" id="TAMWARM"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME41766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="41681" checksum="2974C71D66EB0195" modified="2013-06-26" version="1">MPGFPLSFGVFQEYYARLPQFKDSPFISVVGTVASGISYIAAPIAIPATKKYAKYRRYMIWVGWTICIVSLLAGSFAQSLSTLILTQGVLYGNGFVIFYYPILSMVNEFWIDRRGFAYGILCSASGVSGTAMPFVLSSLLNKYGYAATLRAVAIGLLVLTGPLIPLLKGRLPVSSAVGVSERTDWTFLKGSLFWVYSVSNIAMGLGYFFPALYLPSYAGSNLINATKGAALLSCMSVAQVFGQISFGYLSDRKLPISLLAALTTFAASAAVFTSWGLAHTFEVLVVFALIYGFFAAGYTAMWGRMGTAVSRDPAASFAAFGLLNLGKGVGNVLAGPISGLLISGVGTTSGYGSSRYKAVVLFTGCCMLFSGVVAMLDLARPVIRAVKARADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKT3</accession>
    <name>N1PKT3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_135480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKT3"/>
    <dbReference type="STRING" id="675120.N1PKT3"/>
    <dbReference type="eggNOG" id="KOG3242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064761_3_1_1"/>
    <dbReference type="OMA" id="AFFHYRN"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="9"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME41931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="199" mass="22357" checksum="32559DC20FF599CC" modified="2013-06-26" version="1">MPESRSKHPLVWIDCEMTGLDAEKDTIMSLACYITDAKLNVLDENGYEAVIHHSQAQLDAMGEWCTDHHGSSGLSAACLDSNTTAEQAADELYQYILRFCPDRRKALLAGNTVHADKTFLVKEPWTKITKHLHHRILDVSAIKEAAKRWAPEEVLKKSPSKAGKHEAKADILESIEEARYWKKMFFDGAESRYKAAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKT5</accession>
    <name>N1PKT5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_64031</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKT5"/>
    <dbReference type="STRING" id="675120.N1PKT5"/>
    <dbReference type="eggNOG" id="KOG3361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_1_1_1"/>
    <dbReference type="OMA" id="RGYHEKD"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140132">
        <property type="term" value="F:iron-sulfur cluster chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="9">
        <location>
            <begin position="46"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME42165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="205" mass="21861" checksum="7DE1FCEB70D7D237" modified="2013-06-26" version="1">MFKRVFATVPAQASAAVRQAATSSARPQFASTITKASLAAPARRSYHEKVLDHYNNPRNVGSMKKDDADVGTGLVGAPACGDVMKLQIKVGKNADGQDMIDEVKFKTFGCGSAIASSSYLTELVRGMTLEEAGRIRNTEIAKELCLPPVKLHCSMLAEDAIKSAINNYYTKNPKARATDLGGTGAAMPKIEIEKIGSNDNVQPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKY0</accession>
    <name>N1PKY0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_72924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME41981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKY0"/>
    <dbReference type="eggNOG" id="ENOG502SI94">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034763_0_0_1"/>
    <dbReference type="OMA" id="NLHAVKY"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109936" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="82"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="375" mass="40746" checksum="97F6A3A62F10A8D6" modified="2013-06-26" version="1">MPLIAALLAMALAVAATPFHYPFPQLNCREITIPVNVSAENENLASNSTTPPSTLVTGEYYIRARYCEPAKIVGYRKDTLQLLVHGITYTQNYWSGLAPPGTIPGQDEYSWIKYASDRGYPTLSVDRLCNGLSSRPDGLEKCQLPLEVATMHAIVQAAREGTLPFVGRCFEKIVYVGHSYGSLVANGLAVQHPKDADAYVLSGFSLKVVQGGAPVSTLAKLSTASSALPFRFGFLHEDPNYVVATSQQGVAELFYYGDYDPAVLQFDYDTRGTVTNGESETTPLGQYTAPEYTGAVFVLNGNEDGIFCEQHPAAEGTAGSANCSNGFSSGVHDAYPKARCFDYYNTPNTGHCLNTHRTAQQSFKVTHDWLAREGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL07</accession>
    <name>N1PL07_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_71735</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL07"/>
    <dbReference type="STRING" id="675120.N1PL07"/>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_5_1"/>
    <dbReference type="OMA" id="EDLWVVV"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="10">
        <location>
            <begin position="548"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="483"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME44031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="632" mass="68955" checksum="7D8C20C6EE73AC64" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL27</accession>
    <name>N1PL27_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_24273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL27"/>
    <dbReference type="HOGENOM" id="CLU_1447644_0_0_1"/>
    <dbReference type="OrthoDB" id="10497917at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="187" mass="20796" checksum="54A00B378117BAB9" modified="2013-06-26" version="1">MVDILERPFTVTPKIIKSLKAGRAENHLLIPLTLTTIYPRVDESKLGGSPRIVDTKVRKIEESLQPTPSSCTQRGVLVLPHDFPAREILNQMGKQFEVFVDTDFDADSISEDLSRPIEGSMGALPKHSYKVGEALDVIAVARSIHGGYKAWLARKQSDKEKGWEYLDEIGVLAGVECPVVDELLVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLM2</accession>
    <name>N1PLM2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLM2"/>
    <dbReference type="STRING" id="675120.N1PLM2"/>
    <dbReference type="eggNOG" id="ENOG502SBK0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024465_0_0_1"/>
    <dbReference type="OMA" id="ELHMPMS"/>
    <dbReference type="OrthoDB" id="3913595at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="536" mass="59012" checksum="C18DACF1E1F88485" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLU1</accession>
    <name>N1PLU1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_73384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLU1"/>
    <dbReference type="STRING" id="675120.N1PLU1"/>
    <dbReference type="eggNOG" id="KOG1714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080024_0_1_1"/>
    <dbReference type="OMA" id="IDICHKN"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="2"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME42520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="189" mass="21165" checksum="2630CC94A7DD1504" modified="2013-06-26" version="1">MGIDLDKHHVTSGHRKAPSSTNPYRKLLHKLYTFLNRRTDSKFNATVLRRLRMSRINTPPLSISKIVAISANQHNAEQGDGKIRAVVGTVTDDNRLLELPKLSICALRFTATARARILKAGGECLTFDELALKAPTGSNVILLRGPKNSREAVKHFGFGPHTNKKPFVESKGRKFERARGRRRSRGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLZ9</accession>
    <name>N1PLZ9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_24430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLZ9"/>
    <dbReference type="eggNOG" id="ENOG502SW4P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137478_0_0_1"/>
    <dbReference type="OMA" id="MTIYISR"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17886" checksum="5B6F6841195F1DAF" modified="2013-06-26" version="1">MTLDESSLQAKYDLVKLSVLTSTQISTRTSAVLAKFSRPGDETENSDPTTTPARVGNDNGKPVIVALSAKPKAASKLISIVEISKRELASTKVKCFQYNALGSDIVEIERKSKKGDDESESDEAFETMGAVPLSEKKKRSMPVMTIYLAITPVRELRIAYGEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM46</accession>
    <name>N1PM46_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_73448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM46"/>
    <dbReference type="STRING" id="675120.N1PM46"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_7_1_1"/>
    <dbReference type="OMA" id="MFKDMTI"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000061">
        <property type="entry name" value="Related to cullulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000036">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000011">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="445"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME42610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="828" mass="94789" checksum="5E809275381DE7A0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM69</accession>
    <name>N1PM69_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM69"/>
    <dbReference type="HOGENOM" id="CLU_2291633_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="101" mass="11301" checksum="C942ADB5D6743688" modified="2013-06-26" version="1">MPLFPTSTRPVVEIFVHHGERGRTSLVTLSDFQLLDEEGLAFALTKLEIATIKVYNIVSKERHVYEMKVLEETENFVMSELASWTTTGGWVGITESPGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNH0</accession>
    <name>N1PNH0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_70857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNH0"/>
    <dbReference type="STRING" id="675120.N1PNH0"/>
    <dbReference type="eggNOG" id="ENOG502SANM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021705_1_0_1"/>
    <dbReference type="OMA" id="DFFYVME"/>
    <dbReference type="OrthoDB" id="5410752at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="647"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="757" mass="89526" checksum="393344151C536DEC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNZ4</accession>
    <name>N1PNZ4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_35035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNZ4"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_25_2_1"/>
    <dbReference type="OMA" id="FFANWLP"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="613"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME44648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="68765" checksum="16A1A862098D6AFF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP29</accession>
    <name>N1PP29_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_23243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP29"/>
    <dbReference type="HOGENOM" id="CLU_1906683_0_0_1"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="133" mass="15049" checksum="5C49E8F63947B1AE" modified="2013-06-26" version="1">MDTTTIPQPLHSYSFGPGYYAVLENPTRRQHHVIRSAYTRLKNKSSKVELTYEDPTKQDWTVKEARIQQLETAVTLLTDPGARYKHDVKHQTWDASWTAQEIPASGRNAACTTTSASSRLSGQLDDFGPKIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPL6</accession>
    <name>N1PPL6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_24386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPL6"/>
    <dbReference type="STRING" id="675120.N1PPL6"/>
    <dbReference type="eggNOG" id="ENOG502SI58">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018249_1_1_1"/>
    <dbReference type="OMA" id="FDIHEFN"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF8">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109257" description="ASST-domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="65873" checksum="19202BEEA5037756" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ39</accession>
    <name>N1PQ39_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_71301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ39"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028539_2_1_1"/>
    <dbReference type="OMA" id="KYLTRAA"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="187"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="466" mass="53275" checksum="F914A08956FD0114" modified="2013-06-26" version="1">MDPVLPWQKDSRVSTRKWIYVVVALLTVVLMVLGLGSGPPLGPASFTGAEESTENEKEGLKHAPTTKTTSANMPLPTDLDGFLFDSLRTEQCQGEFPRLFHDIDERVAYWRKQQHSITANDTDMSWRNRDAASGGGGAMRLLIHNNELRILQSTKDNMGHFGMRLRSIAVLGLMQRALDSAIAAGEQLPTIEFATCVEDICAGAPEGSTKSFWAFAARPSDDTHNRRWLMPNYDFWFDHGSGSWRDARRRAIQRDLPFSKKIPKIVWRGNTGFNSVRPALLELTAGKEWADMKNVDWTAETQVNRIHQDSYCNYSMTVNTEGITYSGRLKYLLNCNSLTFVHDMEWTTYWYHLLEPQGADQNYVPVSRDWHDLEEKVRHYLGHPDEAEKIIRNSISTFRSKYLTRAAESCYTRQLIQSYASVTYTPEVYKPDKPGSVKRLRGIPFEQYMSDFRDFNEDELKDAEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ56</accession>
    <name>N1PQ56_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_53590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ56"/>
    <dbReference type="STRING" id="675120.N1PQ56"/>
    <dbReference type="eggNOG" id="ENOG502SKSW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020425_3_1_1"/>
    <dbReference type="OMA" id="LLGGQDW"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="563" mass="64236" checksum="F57CC83DF04E1485" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQH2</accession>
    <name>N1PQH2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQH2"/>
    <dbReference type="HOGENOM" id="CLU_1986824_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="126" mass="13647" checksum="6706A0074493A958" modified="2013-06-26" version="1" fragment="single">LNSTSSLHDFDFAEHDHVPLRTKAAAAHCSSRAISWHAPVLPSLDTTSPRSQCGDSAIKTCIDRSWQPSESSCFTLASALRSGHSARICRRSSVYADDRRRGASGDLSELIFAPSCIKKSQNSLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQQ6</accession>
    <name>N1PQQ6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_34222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQQ6"/>
    <dbReference type="HOGENOM" id="CLU_1224748_0_0_1"/>
    <dbReference type="OMA" id="DEMAYEN"/>
    <dbReference type="OrthoDB" id="3648505at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME45781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="226" mass="25168" checksum="30DAB041B26EA7AE" modified="2013-06-26" version="1">MAFGPVRGLQFFPNAVANPPVNVRIDANDFNDSGNWVISPATKQFSVPVKIGRYEVPDEVQGLNETATNLFLCIDVDSQYFALPQGNPVRGSIVMVRCDGQDLDEHTIYAMAALTVGYINATGRRFKEVTSGELSLETFYIEVKAQLTRERAAKRYQDLKQDEMAYENPFRITPADGVKFCDSCGATQRALGDALFLCGVCGEGRYCSKECQKREWKVHKSSCKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQW0</accession>
    <name>N1PQW0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Modin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQW0"/>
    <dbReference type="STRING" id="675120.N1PQW0"/>
    <dbReference type="eggNOG" id="ENOG502RV5B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009106_2_1_1"/>
    <dbReference type="OMA" id="EKVMGGW"/>
    <dbReference type="OrthoDB" id="5227693at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109534" description="Modin" evidence="1">
        <location>
            <begin position="27"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="64360" checksum="94DC894364547E9C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR31</accession>
    <name>N1PR31_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_71520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSK1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR31"/>
    <dbReference type="STRING" id="675120.N1PR31"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008307_2_0_1"/>
    <dbReference type="OMA" id="YYANDDF"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF28">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="641"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="716"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="818"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="717"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="849"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME45847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="902" mass="98949" checksum="311269C0D5ED535C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR50</accession>
    <name>N1PR50_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_23444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR50"/>
    <dbReference type="HOGENOM" id="CLU_2812316_0_0_1"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="67" mass="7379" checksum="4E878DB1C3DDC747" modified="2013-06-26" version="1">MALPSTSDRSPGCVGRNNGSRTFEVHEGVLSFYSGYFKTTLADKVHNGAIKLPDEDPTIFEAFSLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR66</accession>
    <name>N1PR66_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR66"/>
    <dbReference type="HOGENOM" id="CLU_2196894_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="108" mass="12170" checksum="8D6CC744E759A91D" modified="2013-06-26" version="1">MESALCQWCRNFNLEERHLDPISYDCDGVEFPLTIQDIERCASTCSCCRLILDALSTAAAQARRQSTSIADGDSLKTRRNNLRTLFSTCMSYNSNPIGGKRCTVWSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSG2</accession>
    <name>N1PSG2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_95891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSG2"/>
    <dbReference type="STRING" id="675120.N1PSG2"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014024_0_0_1"/>
    <dbReference type="OMA" id="HMSEVLC"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="502"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME46322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="682" mass="75778" checksum="4A4F639F3A3DE904" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSN6</accession>
    <name>N1PSN6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_33939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSN6"/>
    <dbReference type="HOGENOM" id="CLU_1315387_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="209" mass="22811" checksum="D67DD3B71AFA38AE" modified="2013-06-26" version="1">MADLHYADADEDADADADADEDADADTDADVDAGLSRAHGAFALECGALCSSLSPAQPRESSTRHPFRFNNTRPRQRHCTAAHVPQPAGRRSTTSLQPAQCTCTGQELPSTCARISVSTTTNLHALHLRNTRDQTQRNHSPSIPSIPAAVGACISYVLRVQRDEHLTHSSSSRGRRQSRVRVLMWLMAHSALDRPDPMHAHSMVLFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PST5</accession>
    <name>N1PST5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_71257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PST5"/>
    <dbReference type="STRING" id="675120.N1PST5"/>
    <dbReference type="eggNOG" id="ENOG502S0P1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046457_0_0_1"/>
    <dbReference type="OMA" id="RNDEWEY"/>
    <dbReference type="OrthoDB" id="3981028at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="49506" checksum="A7206E21B7A1321A" modified="2013-06-26" version="1">MASTGTITYQDTLESQYLSNSFSSLSRSRTTNSLVVRTYKQATQLYLTRRFKDAWEVIEPIVSAQHPSDGHVNGGGDRDATGPAAIAQSSKGTRTKVWVFYITLLHAIVDLGSDEGRNTFGSATWRQLAAKVREGTIWDDIVRLGYGGNEGDVDPDVIVNLATLLSSHMQSQKLNQQHLEAYLSASADVAQLAMFQDGTATPMSNNTSSPKELTSRLKIIELYTLHVLPANDEWEYAQQFIEMNDMLDEERREAFLHALQSIKEEKDGTVQRQRELEELREREMEEQRAAEGARRQDEERKEQERRKAAEAEKVRPGSSGVPGSMRPASGTSSNPRPISNDHIADGQSAPKPAKPQKKARIQPQSMYSRASSVLHNFQHTLLQVGRNVTGSNMALMRFLMFMVALILITARRDLRERLKRALQSSWSKLYSTAGMGVKVTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSY2</accession>
    <name>N1PSY2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neutral ceramidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">amd1</name>
        <name evidence="9" type="ORF">DOTSEDRAFT_70482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSY2"/>
    <dbReference type="STRING" id="675120.N1PSY2"/>
    <dbReference type="eggNOG" id="KOG2232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011300_0_1_1"/>
    <dbReference type="OMA" id="GTTVQTC"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109313" description="Neutral ceramidase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="7">
        <location>
            <begin position="59"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="8">
        <location>
            <begin position="589"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME46487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="776" mass="85156" checksum="27BD34DDA52DF64A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT61</accession>
    <name>N1PT61_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_52072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT61"/>
    <dbReference type="STRING" id="675120.N1PT61"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_8_1"/>
    <dbReference type="OMA" id="DHRVGFK"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME46641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="423" mass="46587" checksum="C15EF2FFE9D5E337" modified="2013-06-26" version="1">MSTSLPWICASCWRALARPISRRLNVQRRVQSTAASVSDSISPALLSRARSLASEHASLAQKLASDYDAEAAKRLGELSTTARAIDDYDKARSSWDELQSLLKSSDQELKELAEDDVKPTHEKIEQAEAALKSSLIPTHPFAHLPCLLEIKPGAGGDEAALFAGDLLRMYEAYCAKNGLRTTILKYDVAEGGEHVQEAVLEVETPGAYGILRCEAGVHRVQRVPATESKGRTHTSAASVLVLPAVPDDGGGDLGENSFNDPRSDYYVDPKDVRSEVMRSSGAGGQHVNKTESAVRLTHEPTGTVVRVEDGRSQVKNREKAWSLLRSRIAQSKREEREEELVRLRRGAGAGRVGRENKVRTYNWGQQRVSDHRSGIDSRHLDDIMDGGDALEQVMSSVRTWMAEQEVLGLIVEHEEETKQTKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUD6</accession>
    <name>N1PUD6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_70126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUD6"/>
    <dbReference type="STRING" id="675120.N1PUD6"/>
    <dbReference type="eggNOG" id="KOG3006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115536_0_1_1"/>
    <dbReference type="OMA" id="CSENQNY"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="35"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME46019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="156" mass="17521" checksum="3A4506AD25491A3E" modified="2013-06-26" version="1">MSEPKTVLPDIRSRVATISSHLQPNPIMSQQRPFITCHVLDTVAGKPGAGINVKLKLISPSHATTAHWTAKTNNDGRVPTWTSSTDINEVVEKVKAKLKDDDQMVWSLTFDTEAYFGKGQTFWPEVELRFAAKKDEEHYHVPLLLGPWSFTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUH9</accession>
    <name>N1PUH9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_50533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUH9"/>
    <dbReference type="SMR" id="N1PUH9"/>
    <dbReference type="STRING" id="675120.N1PUH9"/>
    <dbReference type="ESTHER" id="mycp1-n1puh9">
        <property type="family name" value="Canar_LipB"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSW8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029537_3_0_1"/>
    <dbReference type="OMA" id="TTSIWTQ"/>
    <dbReference type="OrthoDB" id="4605274at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053228">
        <property type="entry name" value="Stereospecific_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574:SF1">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109351" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="35160" checksum="7011CB9724F51FF8" modified="2013-06-26" version="1">MSPLEVLVLLFSVRFTIASPIVARDGPSFIFDSDTLFSVDSNDLAASLTCPYGNPSAASPPVLLVHGTATTGQESWGDGYVPALKANGYTACYITIPNRAMGDMQINAEYVAYNLHQISSLSGNLPTAVITHSQGGPLTQWALQFWPSARSITRAFIALSPDFQGVELLDSDSLLSNICASGICQASLWQQSAGSHYYDALHSHEFYALVPTTSIWTQFDGVVTPPDVNAQLPGAQVLSVQSLCPLRPDTHVTMTISSAAYALALDALKNNGVASLARIRKSALGICLRVAAKGMNVNIAKDLGSLLQNLVDGFVLGSPKLDAEPAVAAYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUM6</accession>
    <name>N1PUM6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_70157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUM6"/>
    <dbReference type="STRING" id="675120.N1PUM6"/>
    <dbReference type="eggNOG" id="ENOG502S24K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041456_2_0_1"/>
    <dbReference type="OMA" id="HLRVFPK"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF241">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase" evidence="3">
        <location>
            <begin position="92"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME46070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="228" mass="26146" checksum="744049B974037095" modified="2013-06-26" version="1">MLKAAEASTEQGWERAMINVGGGRQELMLDERNCGRIIWDQSEVATKVWKRIEHQPEVQEIVRLDNVPQIFGNGPQKRGEVWRFSRPNERMRFLKYVGGEYFRPHCDGSYETPDRKERSYFTLHLYLNNAGAPSEDGMAGMDAKERSNFAKMGLKGGATTFHSISMNRDRDFDVMPKTGRVLLFQHRDLLHSGDDVLQGTKYTMRTDLMYELDSTKSGSKSKMPTLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVA1</accession>
    <name>N1PVA1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_41728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVA1"/>
    <dbReference type="STRING" id="675120.N1PVA1"/>
    <dbReference type="eggNOG" id="ENOG502QQTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007201_1_0_1"/>
    <dbReference type="OMA" id="DWHPRNL"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000012">
        <property type="entry name" value="C6 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="813"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="849"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME47302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="984" mass="108687" checksum="5BFDE7E1985CF7EC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVV2</accession>
    <name>N1PVV2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_69456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVV2"/>
    <dbReference type="STRING" id="675120.N1PVV2"/>
    <dbReference type="eggNOG" id="ENOG502S3N6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031811_0_1_1"/>
    <dbReference type="OMA" id="HCHQIFL"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="2">
        <location>
            <begin position="158"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Tandem CCCH zinc finger" evidence="3">
        <location>
            <begin position="533"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME47512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="66883" checksum="B5ABE23D403A772C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWV9</accession>
    <name>N1PWV9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_70633</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWV9"/>
    <dbReference type="STRING" id="675120.N1PWV9"/>
    <dbReference type="eggNOG" id="KOG0626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_2_1"/>
    <dbReference type="OMA" id="HGSNDFY"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME46694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="473" mass="54168" checksum="0AFEEA06EDA8D132" modified="2013-06-26" version="1">MSSASSALRLDKDFLWGFATASYQIEGAVDEDGRGDSIWDTFCRTPGRIADSSSGQVACDSYHRYKEDVALLKQLGAKAYRFSISWSRVRPLGGRNDPNNEKGLQYYEDLVDELLANGVTPMVTLFHWDLPQALYDRYGGFLHKDEYVLDYVSYCRLMFERLGPKVKHWITYNEPWCSSILGYADGYFAPGHKSSTEPWLVGHNILISHATAVKVYREEFKQQQHGVIGITLNGDWVEPWNAADPQDVQACERKLEFTIGWFADPIYTGDYPASMRRQLGERLPEFSAGERALMHGSNDFYGMNHYTADFVKHSKDTPVEENSNGNLEILKTNHAGETIGPETQSVWLRPYPVGFRKLMKWISDRYGRPMIYVTENGTSLKGENDLPVEQLLEDDFRAEYFRNYIMELAKASYLDDVDVRGYMAWSLLDNFEWAEGYETRFGVTYVDYAGSQKRFPKKSARVIGEVFSALCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX17</accession>
    <name>N1PX17_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_77426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME46955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX17"/>
    <dbReference type="HOGENOM" id="CLU_1906680_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="133" mass="14517" checksum="CE9C63A82F5F8FC9" modified="2013-06-26" version="1">MNKNRKLYDDVKSFFDKRQARGIEEQERAAKVANASATGSEVDGMNAVASSWNKLGLHLENTYDEARENFTTEAAMAAFEARPPEPLRPIKQLSIITSTGPGGERKKGEVIVEHVGGNPRPADDAGEEDESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXU6</accession>
    <name>N1PXU6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ferroxidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_69238</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass type I membrane protein</topology>
            <orientation evidence="7">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXU6"/>
    <dbReference type="STRING" id="675120.N1PXU6"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_7_3_1"/>
    <dbReference type="OMA" id="CDIAPGS"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000022">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109416" description="Ferroxidase-like protein" evidence="9">
        <location>
            <begin position="18"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="26"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="153"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="360"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME47220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="65636" checksum="88686B2E579EA569" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYA3</accession>
    <name>N1PYA3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_69785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYA3"/>
    <dbReference type="STRING" id="675120.N1PYA3"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_6_1_1"/>
    <dbReference type="OMA" id="YWVPSNS"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF81">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="181"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME47968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="313" mass="33174" checksum="4F8AAF7A5EE05024" modified="2013-06-26" version="1">MEESIAFIGIGAMGYGMASNIRRNMSTSAILYINDPNADACKKFILENSNIGPVEPVATAMEAAKKATIIITMVPRPEHVREIYLDASTGVLAAAAHGNLSNLMCIESSTIDPATTRSVGKALTEAGVGTYIDAPVSGGIAGAADGNLAFMIGHSTPHPRIQNIISLMANSDKIFFCGPLGSGLTSKICNNYLSGTINIALSESLALGLRSGVDPKVLFEVIKASSGQNWMLEHHNPVPGLVDSAPSSRGYERSFPIPLMIKDLSLGVTAAEEVGVEPSMARRALETYQRASEDKDVGELDYTAVYRLIDRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYN6</accession>
    <name>N1PYN6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_69326</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYN6"/>
    <dbReference type="STRING" id="675120.N1PYN6"/>
    <dbReference type="eggNOG" id="KOG2892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_0_2_1"/>
    <dbReference type="OMA" id="LWQANHI"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000086">
        <property type="entry name" value="Probable porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="14">
        <location>
            <begin position="28"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="15">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME47354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="394" mass="43254" checksum="A0B49296413CB269" modified="2013-06-26" version="1">MASAVQQEDDAHKVLKASKPTESTQTFHVGTRRSILARVQADEVVKALREAWPEHNFEIHAMSTTGDNNQKTALHKFNEKALWTQELEVLLQSKELDLIVHSLKDMPTQLPHDLELGCVTKREDPRDALVLHPTLVGKVHSLKDLPEGAVVGTSSLRRTAQLKRHYPQLQFKDVRGNIGTRLGKLDAADSQYSAICIAVAGLERLGMGSRISTFLSKDNGGMLHAVGQGALGIEIRKDDKRTAGLLAKIGCDRTRRQALVERSLMRTLEGGCSVPIGVETEWVAKKRFHDAHVGVGIKPAKDYHQASGTAVSGGDTSTNAQESEETDELIMRAIVVSLDGQEAAEIETRRLITTHEEAEELGFDAAKLLVQQGADKILEQVQLNREIIKEQGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZ04</accession>
    <name>N1PZ04_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_21923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZ04"/>
    <dbReference type="HOGENOM" id="CLU_976670_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="285" mass="31992" checksum="2DD31DA81982D125" modified="2013-06-26" version="1">MSAAVTFPGCSPTMNMNKGKGTPWQCGAVLNIFLTVLHDFALIQADKDAKERGEICRHFPAQEGKRHSRNLTAVCAASKKKEDLPTFPDEQIEDLRNSNTRQSTRSTRQTIGHKRNAEEMLGISLDHIAPWIIERNIASPTSPHALSAERSERYAPHEPDPPSHAPPAYMGTERGTLVESTPFEANIPDTATPEPSVNAASVKPTRDGILATIGDVFEKLDRETKRREAAEKQSEIYRQQNEIFRDQHENDMETIRSLRNGCTVAKFELRIEALEREKKNLELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZF3</accession>
    <name>N1PZF3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_76048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZF3"/>
    <dbReference type="STRING" id="675120.N1PZF3"/>
    <dbReference type="eggNOG" id="ENOG502T521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_326522_0_0_1"/>
    <dbReference type="OMA" id="HIVRMQC"/>
    <dbReference type="OrthoDB" id="3939134at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="678"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME48388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="882" mass="97876" checksum="1F73726CE5EFA98D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZG2</accession>
    <name>N1PZG2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_21370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZG2"/>
    <dbReference type="HOGENOM" id="CLU_2145795_0_0_1"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="112" mass="12524" checksum="09C742B5A30B6151" modified="2013-06-26" version="1">MKDHEEAYTKALKWRDWYSVGPPSRWLHSKIVHRLLRLGISQQCKDVAQARKSPDIALFDEMNAAGKDQFETFARQQRGTSGEYLGDADGGEYFEVNGGLGWDPGGTGCVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZJ8</accession>
    <name>N1PZJ8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_19442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZJ8"/>
    <dbReference type="STRING" id="675120.N1PZJ8"/>
    <dbReference type="eggNOG" id="KOG3369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053380_2_2_1"/>
    <dbReference type="OMA" id="MPIRTEG"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000007">
        <property type="entry name" value="Putative sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME48951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="146" mass="16319" checksum="5181A6929690B5B2" modified="2013-06-26" version="1">MVVFALLIINKAGGLIYNRTFAPGLQKLDSNDYLILAGTFHGIHAISRSINPAPPAVQPPGNRKPPTTGIESLESSHFRLTCYQTPTGVKFLLFTSPEQPNTDLVIRRCFEIYGDFVMKNPFYSMEMPIRVEKFDRALGGYLVRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZZ9</accession>
    <name>N1PZZ9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_147049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZZ9"/>
    <dbReference type="eggNOG" id="ENOG502SBYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076390_0_0_1"/>
    <dbReference type="OMA" id="HPTRELM"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="24440" checksum="0854AD03A55167BA" modified="2013-06-26" version="1">MSEKRKRDRDDGDAKDERKKQRKGFRVGPDNLPDGVWKRKNQEIKQNLIGKAKIYKEFAKLKKQGRIPEQEESLPQPASLALDEEKEKETEVDTAPHPDRQTLIEREAEEPEETQPRRTDREPRRRKPKPMPFKKEHEEALQRKAEAEGRREAREAAQQERQQKIEEREKFRKAMSKARTGGWNGQRKLGRESKPLLEKVKRIMGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q072</accession>
    <name>N1Q072_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_30445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q072"/>
    <dbReference type="eggNOG" id="ENOG502SHVE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069253_0_2_1"/>
    <dbReference type="OMA" id="DKYEWYK"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF52">
        <property type="entry name" value="DSBA-LIKE THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="224" mass="25593" checksum="0FFC24DE3D37F324" modified="2013-06-26" version="1">MTYGSEIEFTLDTICPWTYLAKRRLATALEQIPTDSPVKFTIKYKPYQLYPDASQEGEDKFTWYKKSRYGDSDEKMKKYTTLMSAYGTGVGINFKFGGTVANTINAHRCIQHWQESKGPETADRFVNSLYRQYFEEEKHPSSHETLVAAAKDAGIDEKEAKAFVEDESEGLMETKMLVREQAGNQIDAVPHLVIIGKRRDTTVEGCREVDEYVKTLNRVVKECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0N4</accession>
    <name>N1Q0N4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_67782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0N4"/>
    <dbReference type="STRING" id="675120.N1Q0N4"/>
    <dbReference type="eggNOG" id="KOG4341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025082_0_0_1"/>
    <dbReference type="OMA" id="SRLDRKW"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="184"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="748" mass="82726" checksum="27606BD70DA1D017" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q238</accession>
    <name>N1Q238_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exocyst complex component Sec3 PIP2-binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_68176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1Q238"/>
    <dbReference type="eggNOG" id="KOG2148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002075_1_0_1"/>
    <dbReference type="OMA" id="SFMRVFP"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.90:FF:000003">
        <property type="entry name" value="Exocyst complex component Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="122"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="619"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1008"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1189"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1195"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1635" mass="179957" checksum="A411478A4E44C920" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2S0</accession>
    <name>N1Q2S0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginase/deacetylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_41152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2S0"/>
    <dbReference type="STRING" id="675120.N1Q2S0"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_1_0_1"/>
    <dbReference type="OMA" id="RNDIRCG"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF28">
        <property type="entry name" value="HYPOTHETICAL ARGINASE FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110398" description="Arginase/deacetylase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="36896" checksum="1088FD50A4F00F3D" modified="2013-06-26" version="1">MLAYTGLLTVAVVLCNAREVTFPPVSGVQLPLAGSGHHADGSNPDLDITQAMFAGLHTYANLPYVHCLAGNDENIEPYDIAILGAPFDTGVTARPGARYGPSGIRQGSQRIAPDFGWSIYTGKNAFQQGLKVVDCGDAPLTVLDNTIALKQLTKAHKITSNRKANASEHTAPRIITLGGDHTTTLPALRSTYQHWGPVSVIHFDSHLDTWDPDVLGGGLSHYAGVNHGTFLHIAHEEGLIRNSSIHAGIRAPIFNKKYDLANDKVCGFHILKARDLDKIGTAGVIRTLKDRVAGSKVYISVDIDVLDPAFAPATGTAEVGGWTTRELLTILDGLSGIEVVGGDVGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3I1</accession>
    <name>N1Q3I1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_68530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3I1"/>
    <dbReference type="STRING" id="675120.N1Q3I1"/>
    <dbReference type="eggNOG" id="KOG3163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1070048_0_0_1"/>
    <dbReference type="OMA" id="TNTPEND"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME49783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="261" mass="29665" checksum="704CFFC5BBDCB71F" modified="2013-06-26" version="1">MPQNEYIERFTKQHGRRLDHEERVRKRAAREAHHASKDAQNLRGLRAKLHQQKRHKEKIQMKKAIKQQEEKNVKSSEPAQPSSTPLPSYLLDRSNTTNAKALSSAIKNKRAEKAAKFSVPLPKVRGISEEEMFKVVKTGKKTAKKSWKRMITKPTFVGPDFTRRPVKYERFIRPMGLRYKKANVTHPELGVTVQLPIISVKKNPQNPMYTQLGVLTKGTIIEVNVSELGLVTAGGKVVWGRWAQITNNCENDGCVNAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q483</accession>
    <name>N1Q483_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q483"/>
    <dbReference type="STRING" id="675120.N1Q483"/>
    <dbReference type="eggNOG" id="ENOG502SGQ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015118_0_0_1"/>
    <dbReference type="OMA" id="IFSWTVY"/>
    <dbReference type="OrthoDB" id="5345392at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="1">
        <location>
            <begin position="388"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="550" mass="60297" checksum="3AC3280466EA5D25" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4P5</accession>
    <name>N1Q4P5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_145202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4P5"/>
    <dbReference type="STRING" id="675120.N1Q4P5"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010348_3_3_1"/>
    <dbReference type="OMA" id="GNWNYTA"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="575"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME50378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="640" mass="72228" checksum="14E9ADF5DDD21336" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4U7</accession>
    <name>N1Q4U7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_68493</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4U7"/>
    <dbReference type="STRING" id="675120.N1Q4U7"/>
    <dbReference type="eggNOG" id="KOG0181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="OMA" id="ATCIGKD"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="4">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME49734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="281" mass="30327" checksum="286B2FC47D3A53D8" modified="2013-06-26" version="1">MADRYSFSLTTFSPSGKLVQIEYALNAVNQGVTSLGIKAANGIVLATEKKSSTPLIDAGSSSKVSLITPNIGMVYSGMGPDYRVLVDKARKVSHTDYKRIYNEYPPTRILVQDVARVMQEATQSGGVRPYGVSLLIAGWDEGIEPEQEAKQAAEGMELDNEKKKTSKTGGVLKGGPSLYQVDPSGSYFPWKATAIGKSATSAKTFLEKRYTEGLELEDAVHIALLTLKETIEGEMNGDTVEIGIVGPPANELLGYEGVEGAVGPRFRKLSPQEIEDYLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2WK82</accession>
    <name>M2WK82_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_179879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.M2WK82"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003600_0_0_1"/>
    <dbReference type="OMA" id="AHGRICH"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16655">
        <property type="entry name" value="RING-Ubox_WDSUB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052085">
        <property type="entry name" value="WD-SAM-U-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573:SF1">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="U-box" evidence="6">
        <location>
            <begin position="876"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="1159"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="1418"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1561"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1561"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1577"/>
            <end position="1590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME39358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1590" mass="174523" checksum="F97B1D16C62D227C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2WMV3</accession>
    <name>M2WMV3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_72681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WMV3"/>
    <dbReference type="STRING" id="675120.M2WMV3"/>
    <dbReference type="eggNOG" id="ENOG502RH77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069253_1_0_1"/>
    <dbReference type="OMA" id="PFWGFDR"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF13">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="7"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="227" mass="25948" checksum="D6BD180AB538D0B0" modified="2013-05-01" version="1">MGKGGHISVYLDCNSPWSYFAYTKLRQHRSALLQHGVTIEMHPVFLGGLNVGSGNKPPWTLPAKAKLGTYDLPRGMKYFGTETLSSPSFFPILSLLPMRCMLYAKEKYPYEQYENALGELWRFLWIEHKDVSKPEVLAECLAKYFRKEDVEKIVKAGTDPQYKKMLTDETGKLVGKGAFGAPWWLVTNQHGVEEPFFGSDRFHFVYQFLRVPFQDIEILPPCAASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y231</accession>
    <name>M2Y231_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_75156</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y231"/>
    <dbReference type="STRING" id="675120.M2Y231"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005360_0_0_1"/>
    <dbReference type="OMA" id="YDLNMQV"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000100">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF2">
        <property type="entry name" value="HISTIDINE KINASE M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="531"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="770"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="710"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME39354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="911" mass="100049" checksum="89BC28D8CED56402" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y2S0</accession>
    <name>M2Y2S0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_117683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y2S0"/>
    <dbReference type="STRING" id="675120.M2Y2S0"/>
    <dbReference type="eggNOG" id="ENOG502SQ74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038498_0_0_1"/>
    <dbReference type="OrthoDB" id="5383784at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="352" mass="40491" checksum="18387BE0A7B9A822" modified="2013-05-01" version="1" fragment="single">MGRQQYLTRLAFGRSAFRDPEPSSLNEPKDEKNNSEYRQQYDSKGRPVNAATDAFNAQLREAQNEVLELVGVVERKDQSDRANETRRRSSREQRQALLAAENDNGEVLEYILLPISFLTHVWVESLLQRVQIGFYDASRSMWDIITHEWHSVRNARGNRRLAMLLPGLGDTIAHLAVRMPVILAAEQIVGRLQVHLLKRCKTRRSRERMCTAMTFGFQTVLAAVDVALLPMELYCSAQRLGLAPHLPLFPPLKFLLPWHGDSFHRFGWLPLLGLTSPAGLLLLHKVIHYDIDEERVPICSLFTPFRYAAITDHPTSSLLTALERPAIREDPLGWVLYQTWLIRTRFMQWSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y336</accession>
    <name>M2Y336_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_83351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y336"/>
    <dbReference type="HOGENOM" id="CLU_2474924_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="88" mass="10029" checksum="A13C6FC6E33825DB" modified="2013-05-01" version="1" fragment="single">MHHLAFASRSNSELMLLTEQLTPPESFSHQARSLQKPSSNTVIRATSRLRCAFLREAGFVFVGRSDFVTSRLLGVHIQQQARWQTMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y5A9</accession>
    <name>M2Y5A9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_72722</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y5A9"/>
    <dbReference type="STRING" id="675120.M2Y5A9"/>
    <dbReference type="eggNOG" id="KOG2509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_1"/>
    <dbReference type="OMA" id="GYTPCFR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110004">
        <property type="term" value="P:positive regulation of tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="146"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="452"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="277"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="364"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME43414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="491" mass="56430" checksum="6A1CA71E855C2992" modified="2013-05-01" version="1">MLDVNDFIKERGGNPEKIKESQRRRHAPVEVVDEVIAMFEDHRQTQYAAGTEMGAKLNKVQKDMGLNKKTKGDPAEFQKLKQEKDDLTKEKQRLEKVAEENYAALLKKIKSIGNYVHDTVPLSDNEDNNRLERAWAPEGTKVEKKDCLSHHEVLTRLDGYDAERGVKIVGHRGYFLTNYGWFLNQALIQYGMQFLFKKGYRPNQPPYFMLREAMAKTAQLEQFHEELYKVTEKDNDPASDKYLIATSEQPISAMHEGEWLNDKDLPIKYGGYSTNFRKEAGSHGKDAWGLFRIHQFEKIEQFIFCKPDDSWTHFDAMINTSEEFYKSLNLPYRVVAIVSGALNNAAAKKYDLEAWFPFQGEYKELVSCSNCTDYQTRELEVRFGQKKQTDASFQKTYVHALNSTLCATERALCCVLENYQTEEGLIVPEVLRKFMPNNEEFLPFVRELPKGSTSLKAKDKADQTKGGVKPKLPQAGQVAERPKAVAEEKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y5D2</accession>
    <name>M2Y5D2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_25386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y5D2"/>
    <dbReference type="HOGENOM" id="CLU_2277406_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="102" mass="11862" checksum="7F13BC8609F24278" modified="2013-05-01" version="1">MPRKPWTSWPCLPWYPNFHGMLVEDSEENSEALVKGETDGLKKLASFDIAIQPGDHFLRKFGSRIQSLLICQPPTKEISISMRCCYCAPPEHPRWPNPHKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2YI66</accession>
    <name>M2YI66_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_75394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YI66"/>
    <dbReference type="STRING" id="675120.M2YI66"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="OMA" id="WIFVPNI"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME38611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="175" mass="18494" checksum="BB3479D5687BD086" modified="2013-05-01" version="1">MMLGFAGYLVFGLPIGLAYDQITKILPLFVVFYGLMLSSGNMGPGDMLGLLSSESYATAVRGTCYGISAALGKTGAAVGTQAFTPIEDNLGKRWTFIIAAICGVAGILVTWIFVPNITGDDLGNGDEKFRLYLVSKGWDGEMGEDDLKALADEGIPASVVEAENDSAFDDADEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJC7</accession>
    <name>M2YJC7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_139618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJC7"/>
    <dbReference type="HOGENOM" id="CLU_2928927_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="61" mass="7201" checksum="1280C042D1303FCA" modified="2013-05-01" version="1" fragment="single">DIYKSILSIITILYRLVTLVELIYIIELLSEVSNNLVVLTSIIEYCSSFLTIREDYVYFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKJ7</accession>
    <name>M2YKJ7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_56858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKJ7"/>
    <dbReference type="STRING" id="675120.M2YKJ7"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073129_3_0_1"/>
    <dbReference type="OMA" id="VFQSTMG"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="236" mass="25869" checksum="33BF2213CA43DC09" modified="2013-05-01" version="1">MAAPPVDYYAALEVDSKATQQQIRDAYKKQALRHHPDRVPSDSPERPTRTKKFQQINDAYYTLSDATRRREYDVTRNQFHGFGGSGGSRPQPSQHDADEEIPRPGQGGFNMPGGFPWSAFGFGGNAKTEEDANRYSNEQFGSVFEEMMQDEGMADGDRQPTRAFWSLVGGVSGGAMGFIVANVPGAIAGAVAGNRLGAIRDKRGKSVYSVFQELDQPAKMKMLSELAQKVFAHAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2YMU5</accession>
    <name>M2YMU5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_132209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YMU5"/>
    <dbReference type="STRING" id="675120.M2YMU5"/>
    <dbReference type="eggNOG" id="ENOG502SV7R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_47_10_1"/>
    <dbReference type="OMA" id="QWRWAET"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME43291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="117" mass="12850" checksum="7C68D09E9FA4B5CB" modified="2013-05-01" version="1">MPAYAAAKAAVQRGLQSLARDVPMVFGKARVNAVAPGVVGTSRFREECERCGEQWRWAETEATVGTARPVPVEDVTRTFLVLASDHFSNRTHGQLQHVNGGKTGSLMWMPDQLAQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC86</accession>
    <name>N1PC86_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_137611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC86"/>
    <dbReference type="eggNOG" id="ENOG502TM8H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139874_0_0_1"/>
    <dbReference type="OMA" id="HAGMRGS"/>
    <dbReference type="OrthoDB" id="3625848at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17586" checksum="1614F1328C669A7D" modified="2013-06-26" version="1">MTSLLSPPDTVAKAEEGRVQKIGAELERLTKTCIDAINLRDWDYTSPERQEFLSHVHPSFTAVFDNVPGKLDWAELNTAWRAMFAEHPEGQFNITRMSTAVDERAGYGAVVIESEATGVSNVVLHGLSEAKWRRVNGKWWFYWHAGMRGSSGNSGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCK3</accession>
    <name>N1PCK3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_39561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCK3"/>
    <dbReference type="STRING" id="675120.N1PCK3"/>
    <dbReference type="eggNOG" id="ENOG502SAV6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070614_1_1_1"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="10"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME38588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="336" mass="37073" checksum="728217CE33CF9A56" modified="2013-06-26" version="1">MAITSSTPTITTCVKVNNASLQEYTNPATTDSGTTTTRYIEALTGQIFEIHADIAAGTPFVGDCLAFYISVDGKMADPTLTFLSGTTHTGSSVVSKGIYTAGNMVRKYRFEELGKTNDGGIPSKEQVEAAMELGTIRVEVHHQMSKARVDGGLDLFGSLKTVDAIDERAVKGRAISSTTSYAEAVANDGLHVRYWDTEFLDPDMKPMAVFVFKYTSREDLQAMDMIPRDPTTESEETEPESEEAEPDIATMTHEEMAAELRERRQAEKDATVNSDDPYETMEVSAYHVQIKREHMDDDQRPTRDKRFKTIITLGDDGEELEVVTTLLPGPEAETIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCX3</accession>
    <name>N1PCX3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Arsenical-resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_157114</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCX3"/>
    <dbReference type="STRING" id="675120.N1PCX3"/>
    <dbReference type="eggNOG" id="ENOG502QPKH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022869_0_0_1"/>
    <dbReference type="OMA" id="MVLMWGY"/>
    <dbReference type="OrthoDB" id="187348at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME40423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41170" checksum="1A310E38E59C6659" modified="2013-06-26" version="1">MERHTPPAGAPTSEHLQDPEKQTTGDAPTVETSVYAGLNWLDRLLVVWILLAITIGILLGNFISNIGPTLQRGKFADVSIPIAIGLLVMMYPILCKVKYETLHKVFAHRQVWIQLGFSIVVNWIIAPLVMLGLAWAFLPDEPGLRNGLIFVGLARCIAMVLIWTNLANGDEEYCAILVAVNAILQMVLYAPLAILFVKIIGHSSDGGDAISYSVVARSVGVFLGIPLGAAILTRFALRAVNAKWYEDVFLKYLAPWSLIGLLYTILVLFASQGKQVVHQIVSVVRVAAPLVCYFAIIFFATLLVCKRMGFGYKLSATQSFTAASNNFELAIAVAVATFGADSDEALASTVGPLIEVPVLVGLVYLVRWIARRWGWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD32</accession>
    <name>N1PD32_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_158617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD32"/>
    <dbReference type="STRING" id="675120.N1PD32"/>
    <dbReference type="eggNOG" id="ENOG502S89B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074184_0_0_1"/>
    <dbReference type="OMA" id="WHDEWML"/>
    <dbReference type="OrthoDB" id="4850648at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827:SF1">
        <property type="entry name" value="HNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29552" checksum="3C11FBA45B5839E1" modified="2013-06-26" version="1">MIAEYEVSNFESFQDCLSTSIIQRLAPDSGETAKKRQIKGRKNEIKPVAKVKQDVENNDAAELSEFVEYLAEEIFLNMPAELRTLSYAAVQDDAELASRYSVPLGNAEIESLIKPLPLSVPESLTTYGLINDESDLDHFLEPCINSYITTTSEPPAEYTPALTATRPGGCEICDREHVPLTYHHLIPRQVHAKVVKRGWHKEWELNKVAWLCRACHSYVHRVAPNEQLARELYSVDLLLEREDIQRFAKWVGTVRWKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD41</accession>
    <name>N1PD41_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_75786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD41"/>
    <dbReference type="STRING" id="675120.N1PD41"/>
    <dbReference type="eggNOG" id="ENOG502RNP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_792327_0_0_1"/>
    <dbReference type="OMA" id="RMSTACT"/>
    <dbReference type="OrthoDB" id="5426798at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME38354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="350" mass="38531" checksum="471574A3AA860E76" modified="2013-06-26" version="1">MATYYDISHPNPLYSRRPAFEPSRPRYDPVTEASPRVPRAPSADDRPIGRVTRQPSQESTPTRTLPGLSELFASKLLVAPNAKKGRTATGSQSGTYNDQTVKAASAQLPTGRHDSVVGWQSPPRYTTAPALSSSAPTTPDAWTSELPPFQNAQRHSSTQHGQANPASPAFRSESFGASGLGGHNASWAPEHTISRHGYGPLPTHHHEDNPLHRVDSRVGWREAESRPAVAELLPATYMYRTDCGMIAGPPSYPDCPVGFPIPGREDLYPIWDLTKRKLPRKRMSTACTDCRKKKIRCEPGVGGCLQCRKVQKPCVIEPVKRRRRKKALSEDADAEDSDDGSEELEKSRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD69</accession>
    <name>N1PD69_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_91337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD69"/>
    <dbReference type="STRING" id="675120.N1PD69"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_0_1"/>
    <dbReference type="OMA" id="PILAYWE"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="35"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="326" mass="37597" checksum="E1B2E46199E8CBE5" modified="2013-06-26" version="1">MDKLNLKDFRCTRGFTYHYYISDGPSEDTRKPTFSALWQFIAPRFVELGYKVVVPDLLGYGGTSKPTDPEAYVWAEQARDLIEILDHEGVRKIVSIGHDWGSVIAQRVYHFFPERVVGIALLSVWYFPPLKDDKPLNLQAVNDYYEKVDGYRRIEYQTFFIEDDASKIWEEHLESAWTALHAEGPESMKRLFCVPGAFRNYLVSDKKDVALRPFAQNNALRDVWISDMKQGGLTAPFCWYKSRQLNVHGNSEKDLPEDRARVTVPVLYISGDEDKVCLGKDILPMKEAGLLPDLKIHELHSGHWLPYERPEEVTALLKDWLNNNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDC5</accession>
    <name>N1PDC5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_105030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDC5"/>
    <dbReference type="STRING" id="675120.N1PDC5"/>
    <dbReference type="eggNOG" id="ENOG502RHP1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2176972_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12543" checksum="95761A422F6B3335" modified="2013-06-26" version="1" fragment="single">MDIFVRHIPTHATQKQLDFYFSGPLKACGITDYHVEKLGDKPNAIITVLDTFAGQRFLQQYGVPIHAPPHLRAPLNLTWDNRNVQCMKARNDPSDISLQAILFDKSQRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDL0</accession>
    <name>N1PDL0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_56435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDL0"/>
    <dbReference type="HOGENOM" id="CLU_1372186_0_0_1"/>
    <dbReference type="OMA" id="EVKWLEY"/>
    <dbReference type="OrthoDB" id="10528547at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="199" mass="23042" checksum="7A3522B75BD68C85" modified="2013-06-26" version="1">MSLHSRALLYTSNQTTDSPKSLLDDISHTLVTPTLSVSTREDVRKSCEELATVFHIPPLTRIQLLLWAAKSQSTTLPGATYLQACRVRAEFARFWMEMVKEGLYNRRAEATAEVKWLEYDVKMLREKLNEMTPEVLVKEFVQRKSEGLDVKERVEGVGKWATPNPEFSERMFEHPIFSLQYAIFQDRQLERRECEDVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDS7</accession>
    <name>N1PDS7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDS7"/>
    <dbReference type="STRING" id="675120.N1PDS7"/>
    <dbReference type="eggNOG" id="KOG2659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073203_0_0_1"/>
    <dbReference type="OMA" id="KMILWAQ"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="64"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="245" mass="27693" checksum="88008CCDFFEB2FA0" modified="2013-06-26" version="1">MSATFPPSTMRPAHNFDRKVEEMKPSKSDINWVIMDYLVSEGYPSAAEKFAQETNICSPEDINSIKERVNIRNSIHAGRLDDAIQMINEVDTQILDHNRALHWSLLQLQLIEIIRPILKKYGSTNPPSNEWVPVLQFATEQLAPQAPTHQDYQTALNNTMALTIFSEDKMPVETKQLLDLKLRETVANRVNKAILESRGQRSEAKIRQLVRARAWAEAQAREAKVDLPAFPIPIGLEPAGEAMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDX3</accession>
    <name>N1PDX3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_37850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDX3"/>
    <dbReference type="HOGENOM" id="CLU_525819_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="518" mass="56292" checksum="724F94B289C7BF33" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE33</accession>
    <name>N1PE33_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_158390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE33"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="OMA" id="SVFDWYP"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME39835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="517" mass="58281" checksum="04A7A74411A0A007" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PER1</accession>
    <name>N1PER1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PER1"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="OMA" id="RMYTTSS"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF2">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G13450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="27248" checksum="3A9F244BE83C5E90" modified="2013-06-26" version="1">MSHQNVLIVGATRGLGKELAKQYHEAGHNVSGTARSETPDDSLGIRWITGVDISESQAGTTIVSGLRNERQDVVIVSAGYFPKESLDEPDFDKEVFTYKVCAIGPVFVVQSLWKAGLLEKGSKVILVSSEAGSIALRHASEGGGNFAHHGSKAALNMVGKLLSFDLKDAGVAVGLVHPAFMRTEMTAGVGFDKFWDEGGAVTPDESAKSLREWVETFDISKTGTYWAPRGPGDIGTAEHVLGPKAKLSTPLQLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEU7</accession>
    <name>N1PEU7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_91388</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEU7"/>
    <dbReference type="STRING" id="675120.N1PEU7"/>
    <dbReference type="eggNOG" id="KOG2054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003502_1_0_1"/>
    <dbReference type="OMA" id="NPHGGKE"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="213"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="364"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="509"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="679"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="868"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="1029"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME40115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1167" mass="129655" checksum="B9EC476236AE5C63" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF69</accession>
    <name>N1PF69_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF69"/>
    <dbReference type="HOGENOM" id="CLU_2133445_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="113" mass="12611" checksum="BE944D58D95B1FAB" modified="2013-06-26" version="1">MDHLCPRLASQHAACMFCLAGIDMSIRPSNTPNLALRPRDSGCAVWWSRHANNSSPKRRTTTQKANQKTNKSNKRERHAPNSDIRGMFSRPRIFRKDSATLPTNPLGQPASAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFD0</accession>
    <name>N1PFD0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_26501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFD0"/>
    <dbReference type="HOGENOM" id="CLU_1758772_0_0_1"/>
    <dbReference type="OrthoDB" id="3878372at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="148" mass="15941" checksum="B8673D7BFB849917" modified="2013-06-26" version="1">MNTTLSSPETSSCGSTSGRHFSLLNTPTTSHCFNLNNTFSNPNVTIPGFQYDLLNTASFNYSTNHSQISYSQPSTASQQPSNLTLKTYNGLDCIRIAESYGLIEPWTEWTCATSSGGECSTLPYSVRSFVIGPSSEKGRKGKCVVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFF3</accession>
    <name>N1PFF3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_28201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFF3"/>
    <dbReference type="STRING" id="675120.N1PFF3"/>
    <dbReference type="HOGENOM" id="CLU_2084784_0_0_1"/>
    <dbReference type="OrthoDB" id="5301876at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="117" mass="13106" checksum="3925AC1F783F5266" modified="2013-06-26" version="1">MDNIGVAAVPEFEVNNSAVKKHNYATSRDSFMCALFVLEDMPIGSTNEVLSRNEDEATGTCFWLAEHNNKLPDFTGMSVDVESAPIDENWRQHFVGATLEDLADYVRAVPRPPKWLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFS5</accession>
    <name>N1PFS5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFS5"/>
    <dbReference type="STRING" id="675120.N1PFS5"/>
    <dbReference type="HOGENOM" id="CLU_560225_0_0_1"/>
    <dbReference type="OrthoDB" id="5386682at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="487" mass="55995" checksum="303ABBD81A320331" modified="2013-06-26" version="1">MGRIYEQADKVLAWLDAPDKSLESLRWFASATSYGPSQVHSKYWWRSSGEEGCREVMDIIFRLPYWTRKWIIQEIILARTVVLMLSDGEFAMREVEDAMISQEKLHMRRYPRSLPFAKLAIHRWNKRNSRTTAYPRTLSELLPMYESNDCKEPMDHVYALYNLIGDHREHLEVDYRQSQSTWCQKILLFLDKYEAPGKNNTIAMALRLVRLAPQARFDEMMSFSGEAPAEVTAVALDRGAIRPAEESAYSIHLRDHVEALHPGLRWTFQSQSHTAFRLSQKTATNTLERVSRRTLSFFEQPESQLYGMATMRVRDGDYIWQFLGTQFAFVCRSDPRDKSLVQVLGRCHLFKAPFTNEPPFGALVRATLSHEQPQQYRELRITELRLSIPDLFALAHSANDPGWPHAATELHSAVTESRAQQANPKITELHPTLERDRHSRGSSPSSRSLHEAVEKTRKLATESKESVGTALGMPPPSYDATTMRHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFZ6</accession>
    <name>N1PFZ6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Antiviral helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_176340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PFZ6"/>
    <dbReference type="eggNOG" id="KOG0947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002902_1_4_1"/>
    <dbReference type="OMA" id="DHVNIIM"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="319"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="607"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="530"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME41287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1286" mass="144784" checksum="CD9A76C502BC02DF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG58</accession>
    <name>N1PG58_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_74192</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG58"/>
    <dbReference type="eggNOG" id="ENOG502QU6M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021993_0_0_1"/>
    <dbReference type="OMA" id="ALQLLYW"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="80"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME40550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="470" mass="50803" checksum="53FF9A4CEE9C2E8E" modified="2013-06-26" version="1">MSTEHQNGTSSTAVIQPVELQPSPSNQEQNRTKQPFVGGRSLGSINTDDNGNDRNESLPSPTTASQPQETWKDPKGNVYKVTAAFWAFIVMGMNDATYGAIIPYLQTYYNLRYAIVSLVFLSPFVGYTASALLNNAIHLRFGQRGVASLGPLCHLLAYIINCIHPPFPVLVLSFILAGFGNGLLDAGWNAWIGAMANANEMLGFLHAFYGLGATIAPLIATSMITKANLPWFNWYYCMVGFAGLELAWSIHAFWAASGIKFREANGRTSDAKGSRLREAVFQLPAARVTWLCALFLLGYVGVEVALGGWIVEFMIQVRHAAPFPSGMSATGYWLGMTVGRVVLGFVTPKIGEKLAIMIYIPIAMGLELIFWLVPQFYVSTFAAALIGFFLGPLFPAVVVVCTKLLPKHLHVSSIGFAAAFGGSGGAILPYAVGAIAQAKGVGVLQPIVLALMAVILLLWFGLPRMNKKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGJ7</accession>
    <name>N1PGJ7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_36893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGJ7"/>
    <dbReference type="eggNOG" id="ENOG502ST70">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559003_0_0_1"/>
    <dbReference type="OrthoDB" id="4142625at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109083" evidence="2">
        <location>
            <begin position="17"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="488" mass="53502" checksum="58C9ABB5C2D6DB0D" modified="2013-06-26" version="1">MAFMTYIAAVVLQTTAASTITARRDADIESLHPIHKTITYGTYDVPPRSQDNGMLRFKQDHDPPCTDCLITSISVNIQYPDGTTADPTNGMWMHHMTFANKGRLDGVCGDQQPAQRFFGAGNDRSPLDLTIGGTHQIGYHIAPHDTLLLSAELMNFHSSSQRIILTATWSYVLSSSPLYTQYAPAMPFWLSVSGCVAADMPAAADSEFTYSSPAFILSPTSDNATGVRHLAWLGNHVHDGAKLQNVTRNGAVICSSEAEYGAESGVDGIAHFEQMPFCTDLGPVESEDEFVVTVEYDTKKWKPMVNEDGTLEGVMGIVLAWVVDSGVVDGGIEVENRDMGGFGVAIGVVMVVTVALLVGWFMLVANRGRKNVWWKSSRYDEVTMRYSRLMSLQGPRKSHSRLSAFSPGRVPHGKNSKVQSAYKNRYKITAASSSLRRLCEGEVSTVTFRTVKASWLLTYSKANSDYETPVLGKATITRDRAGQWPSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGN8</accession>
    <name>N1PGN8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_26900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGN8"/>
    <dbReference type="HOGENOM" id="CLU_595840_0_0_1"/>
    <dbReference type="OMA" id="RNEDARC"/>
    <dbReference type="OrthoDB" id="10414979at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51910" checksum="17BC77E7F9A4E3B8" modified="2013-06-26" version="1">MASFNLTIRPAWLQDAQKVLNDLLYDASTAKEEDHQVKKHLDQMAEYNHTATTDTTIESIWPSRDDAMPLDAQRYMAAFLSSASSPFVPADTVATVLKNSGYINEKRKILGRTLLFHQITTPGTMTNTQIPRSRPQPFQDLPAELLALIRDSLPPADVIALTFTSRSYYTTLDFQLVDLRSLVLASDLHAAFPYQKFSHAINRERYDVSRRLRRDKTAHLLKLEDHTNDSILCSACTALHPARYFSPAQLASTPLQRTCLATEAKLRFCTHWSETLQTLRQRNEDARCKSSAAPANGEETCQDPEHYTPEGTVYDPPPSLRQLGGVQYVSKTIRMGHTDDYNLLTAESVKEALEKDPVAHVRVCGHVKAGDEEVVGSFERKEGLVEGNEWSVDMPQFEVGCCEVCGMRWQFRVKDMLGRCVARYELQLSVEWELRAVREAWTKEWLGLVEGGDELTELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHD4</accession>
    <name>N1PHD4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHD4"/>
    <dbReference type="HOGENOM" id="CLU_2483333_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="87" mass="10177" checksum="1D6CA878B3A2244A" modified="2013-06-26" version="1">MRLGTLVMYNLRARKSVSYQDCISLYFRVNARRVVHAELDFQQGGTRARSGEEFLHRRRRKVWKPVTSHRVGTAYHAGRLSHWYGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHL3</accession>
    <name>N1PHL3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_26976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHL3"/>
    <dbReference type="HOGENOM" id="CLU_1845056_0_0_1"/>
    <dbReference type="OrthoDB" id="60204at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="139" mass="16066" checksum="5FC9A8EFB4FEDE61" modified="2013-06-26" version="1">MATADMLDGTGARVANTYELLEAILLHIPQYLNGTLILAKATSKSFAAVITRSKNIQKRLLIDLPVDHDSVGIMRWAPKFYETIVTMRYKSSHDRLHARAVIDLERLRNTEDAFHLNSSWRDRWLVRESTKRVTMEKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHQ3</accession>
    <name>N1PHQ3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHQ3"/>
    <dbReference type="STRING" id="675120.N1PHQ3"/>
    <dbReference type="eggNOG" id="ENOG502R0RC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637823_0_0_1"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="372" mass="40981" checksum="D6A1D8B1EDA6841B" modified="2013-06-26" version="1">MAENAESSPPELSFIVYENDADLKQPRREVRSHVARAQHRRARKSHQGASKGAQRAAGKDTRAQRNHERRTTAAVEVHGEVHGEEKGRPSRASKGPCRLTAEGSRARQSARRVPIAATPGTTLPGVSTAIPSAAQLVQAGGVERRVVRESVLDDPADKMASILGRLQLDFPTVMEQYKWIVWAQSPDWQRIFAPDMPPGEGSREMLGRLSEDPALIATAALIGTSHIVDILYSRLDTLISRCIMDLRGFVTRTINGALRDPERGTCDAVIGAVLLLATDEGLQGQIESYHAHMRGLVQMINIRGGLISLNRRQLYLESLVKWQDANVSVAMGNKQTYYSMCDNPSLDLPEVTPCLSLWPRTDGVSVRKQLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI94</accession>
    <name>N1PI94_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_135635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PI94"/>
    <dbReference type="eggNOG" id="ENOG502SZI9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083110_0_0_1"/>
    <dbReference type="OMA" id="SKAFIWP"/>
    <dbReference type="OrthoDB" id="5331170at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="221" mass="26096" checksum="960966EABF5BE052" modified="2013-06-26" version="1">MAYPFHPQPLSEDYQQAAYNGFPFVPEFGHRRNAPREEPFVHYRPNRGWYQGGRKLENFKSKKYWARPVDGARRGTLGRIKDGLTGEGPDVFVVMNGDRRTLHRDMPKRGHWSHWDENGLGWLNRDPDWRGAAEDMDWLPPGNLGSTPWARRERDEVYNFRTRRYSEIQPGYKWGFWSDAHWPHGHRGKWSLPTCWRDWDGHWNTTVDGSAGRWPGGRPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ19</accession>
    <name>N1PJ19_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_73830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ19"/>
    <dbReference type="STRING" id="675120.N1PJ19"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015497_0_0_1"/>
    <dbReference type="OMA" id="RYIFEKT"/>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000236">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp9), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="69519" checksum="B0D99453A2912CD0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJH7</accession>
    <name>N1PJH7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_73923</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJH7"/>
    <dbReference type="STRING" id="675120.N1PJH7"/>
    <dbReference type="eggNOG" id="ENOG502RF2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013691_3_0_1"/>
    <dbReference type="OMA" id="VQGTGVH"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109832" description="tyrosinase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="14">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="414"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="677"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="416"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="691"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME41685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="773" mass="80541" checksum="DA9A885CB031D9E5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJS0</accession>
    <name>N1PJS0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3">2.1.1.233</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein phosphatase methyltransferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_81456</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3"/>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJS0"/>
    <dbReference type="STRING" id="675120.N1PJS0"/>
    <dbReference type="eggNOG" id="KOG2918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031312_1_1_1"/>
    <dbReference type="OMA" id="IIYEPIR"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME42642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="380" mass="43298" checksum="634C27B373339420" modified="2013-06-26" version="1">MTSANTILQLLEPQILSMSSIPNLNTLRSRGPRLRGRRGGPRGTGEIDDGPDTEEIQKSRDQIIQQTDHDASSSRMSAVSLGYFEDEYAKAFFPANQEVPKRYPIINRGTYVRTKAIDRLVIQFLETNKGERKQIISLGAGSDTRFFRLCAGKHQVTYHELDFESNVIPKRVAIRSSQQLSRMILPQQDDSSYHLHSIDLRDLTKKSPPIVPDLDNALPTLLISECCLCYLPPDTASSVVQYFTMNFPGSLAMVLYEPIRPYDAFGKTMVSNLGSRGIELRTLKRYYSLEAQRQRLKMLGFEDGQGARDVHQIWGSDDWVSAAERERIEKAEWLDEVEEWQLLASHYCVAWGWRGDVFQPAWGDVEGDRTTEEQKDDDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK31</accession>
    <name>N1PK31_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_73522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK31"/>
    <dbReference type="STRING" id="675120.N1PK31"/>
    <dbReference type="eggNOG" id="ENOG502QVZ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015321_0_0_1"/>
    <dbReference type="OMA" id="METIYEA"/>
    <dbReference type="OrthoDB" id="2121319at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120:SF1">
        <property type="entry name" value="M PROTEIN, SEROTYPE 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="714" mass="77289" checksum="3471D0D384502782" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK65</accession>
    <name>N1PK65_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_73915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK65"/>
    <dbReference type="STRING" id="675120.N1PK65"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1038439_0_0_1"/>
    <dbReference type="OMA" id="ENTEVEW"/>
    <dbReference type="OrthoDB" id="5354320at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF25">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="163"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME41676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="297" mass="32611" checksum="B20369C89D905437" modified="2013-06-26" version="1" fragment="single">MEAGWPLIKFLFPQVPSMSWAATQNALGLTDTSKFWDTRTAVTVHVLRSLMSSDGKKEIPPISKIQQSTLRDPGLKGKTWVATVTIAKPPQEEGDVREAIFAAVDAMKKEEVTYTKPECENTEVEWTGYRPNAANGEPLPNISEEEKYRRMMAEPTRTSETTILYFHGGAYYLCDPRTHRALTSRLAKESNGRVCSVRYRLAPQTAFPGQLIDALMVYLSLLYPPSGSMHAAVPAEHIVLGGDSAGGNVAFALLQLILQMQRSTSGAVPVVKFHGRDVHVPLPAGVSANSGWLDISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK75</accession>
    <name>N1PK75_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-CoA dehydrogenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_62331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK75"/>
    <dbReference type="STRING" id="675120.N1PK75"/>
    <dbReference type="eggNOG" id="KOG0139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_4_4_1"/>
    <dbReference type="OMA" id="LWAWIES"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF15">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE APDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="157"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="265"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME43726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="47828" checksum="0E34BA190447AD4A" modified="2013-06-26" version="1">MQEKEPIPFSEPPWLLGHPSPYYTDSHRKWQKFCRTFVDEHFTPYAMQWERDGEVPAHVYDTFAKHNMMVPNIPTPLAVKVLKSVGIHRVGPVAVEEFDYLHVIIYSAEMIRCGLMGPVTAITTGFAFGVPPIVHFGSPELQEKFLPDLLTGRTRICIAITEPDAGSDVANVQTVAEKTADGKHYIVNGTKKWITNGMWSDYASMCVRTGGDGPSGLSVLLVPLKNQEGVSMRKIPVIGGRASGTTFIELDDVKVPVENILGKEGHGMKYIMTNFNHERLTIATLVAAQARAALSAAFEWVMKREAFGSALINQAVVRNRLAKAGAELETLWAWIESFAYQMCQFKKEEADVKLGGLTALAKAKAGLVLNECGQCAQLLFGGNGYTEIGQGELAARIAKEIHGARVPGGSEDVLLDLAVRQLYKNYQRQTYSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKI9</accession>
    <name>N1PKI9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DOTSEDRAFT_44304</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKI9"/>
    <dbReference type="STRING" id="675120.N1PKI9"/>
    <dbReference type="eggNOG" id="KOG3525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002976_2_1_1"/>
    <dbReference type="OMA" id="RCCGEIA"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005690493" description="P/Homo B domain-containing protein" evidence="18">
        <location>
            <begin position="17"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="19">
        <location>
            <begin position="494"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="654"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="807"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="810"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="828"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EME44012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="857" mass="95271" checksum="ED8B2BAC4B5DEACE" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKY8</accession>
    <name>N1PKY8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_54626</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKY8"/>
    <dbReference type="eggNOG" id="ENOG502SKG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_6_3_1"/>
    <dbReference type="OMA" id="WGYINGE"/>
    <dbReference type="OrthoDB" id="3626004at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109882" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="23"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="35"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="481"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME42200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="598" mass="65823" checksum="06B410D4E138DC25" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLG8</accession>
    <name>N1PLG8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_24405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLG8"/>
    <dbReference type="STRING" id="675120.N1PLG8"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_4_2_1"/>
    <dbReference type="OMA" id="FNIIDEM"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF461">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="88"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME44347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="546" mass="59848" checksum="D70DAF883F8F8169" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM15</accession>
    <name>N1PM15_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_53268</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM15"/>
    <dbReference type="STRING" id="675120.N1PM15"/>
    <dbReference type="eggNOG" id="ENOG502S7WD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038503_1_0_1"/>
    <dbReference type="OMA" id="WYLETTF"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="13">
        <location>
            <begin position="188"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="340"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="385"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="51"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME44053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="469" mass="52377" checksum="BE827C66AE10F5FF" modified="2013-06-26" version="1">MSAIQELSQQLTALFDCLKTTNTLISRLHKLKFVPGSEPIEADSGVRVELAQDIHDSLKQLEEELEFLQQEAEEYTTEGNRFRRHSSTDGEEARLQAKVVRLKDELAHSRQKFRNAQVAAKFASDEAKKREREAVLEGYRKEAEQLAAAGEQPNGSAGNQRELLFASRGRRTQSQKQLTKDEILVTASSDLTAGLRRTYDLLSTEVSRSRFAQETFEESTAALAQLGEDYTSLDSILSNSRNLLSTLLRSQKSDTWYLENAFRILIITLVWLFFRRILYGPFFKLPLFLWNIFALLTNWLFLKPLFFLLSVTGVLTTGPASTTSVAASSSTRAPLIVQASAKGKSHPRPSHVIAGQPAGLGGTGAKVGKDPELEGRISESIVRMVQESGRNDLPRRGDGTVLEERGDTPANPKKKSFEADVEEARQAEKEPPPRGDGIVLEERDEPANPKKKYFEVDDVDAKRANRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN24</accession>
    <name>N1PN24_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyketide synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pks4</name>
        <name evidence="4" type="ORF">DOTSEDRAFT_24654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN24"/>
    <dbReference type="STRING" id="675120.N1PN24"/>
    <dbReference type="eggNOG" id="KOG1202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_621157_0_0_1"/>
    <dbReference type="OMA" id="CAYTAME"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF21">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="3">
        <location>
            <begin position="198"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME44831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="441" mass="46913" checksum="67A7868C1A617824" modified="2013-06-26" version="1">MSAIARRSSNDGRKQVDYTQAGYVHAYISVVSDACSVTVTAHHFNMDAITTSLSEHGMSTKTLALIGSYHNHENEPIATKVNSALDSAGYGISLQGSFAPVRSNSTGEIMNGSDAFGCIIDDIFCRQLDWHNTVSEAADSAPASSADPATTIAFGTVEYFPSVIKSRFKVTAQRLSVPEVASPSPVASRVEPTLEYPYHAVADVALACGFPRADGLDQFGNLLSSGRSMHERMPAHRFATTGLRRSNDSAPFWGHFMKDVDAFDHQFFKKSSREAASMDPQQRLLLQCAYTAMESAGHLAPTSGAKTRNVGVYIGACSNDYNDNFAPHKPTACWTLCTLEAFLTGSISHYFDWTGPSIIYETACSSSAVAIDAVCKAIASGECSQAPAGGVSFTGPCKPFDASADEYCRGEGAGLVVLKGLKAALADGDDIRFVIASTGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN36</accession>
    <name>N1PN36_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_34794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN36"/>
    <dbReference type="STRING" id="675120.N1PN36"/>
    <dbReference type="eggNOG" id="ENOG502R8K2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1927550_0_0_1"/>
    <dbReference type="OrthoDB" id="4114509at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="131" mass="14857" checksum="D0594D72ED82F570" modified="2013-06-26" version="1">MFNCATLSLVELEEIQRSNQVARKRRVVLIAPGEVTLENGTYHPIADSLYIDCTADALTKLEAAPLFRGKTITLRPVRHCQRVFSAAFIAHVGAIYDNDRLINELCRIVPHPDERINHLSVYLLDRMSQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN94</accession>
    <name>N1PN94_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN94"/>
    <dbReference type="HOGENOM" id="CLU_2078574_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="118" mass="13157" checksum="72ABCD4F64DE403F" modified="2013-06-26" version="1" fragment="single">MHLLTSRSLWITVTALQPGQDKHHTRQPIATVSTLFQRPCCMLSIKALCGSAWLMQSRRAGRHIMQPRCMARRSGSGAEAAVVVAKTKHASAIACARMFRRLAYLVLWTNLDDVVRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP35</accession>
    <name>N1PP35_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_127800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP35"/>
    <dbReference type="STRING" id="675120.N1PP35"/>
    <dbReference type="eggNOG" id="KOG0362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_4_2_1"/>
    <dbReference type="OMA" id="WGLKYAV"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME45162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="560" mass="60297" checksum="4DED1C63E899BC2E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPA5</accession>
    <name>N1PPA5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_80033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPA5"/>
    <dbReference type="HOGENOM" id="CLU_1570618_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="170" mass="19236" checksum="B7522650D127346D" modified="2013-06-26" version="1">MAAYWIWPRLSKTSKCLWKRRQSDDTRQELASIRDVIEGVRMTVDENIPSVEELLITIQGTFDGNISEIEKAVHDILETVNDNVPEVAETVDQVLNELDQVGNAVIDCYNNGTYDEILGRVAGGNNTMSTMTRKIPNAEVVTNLVVQNLTAWMIRQCTRVEVRYSAFKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPH0</accession>
    <name>N1PPH0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_61864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPH0"/>
    <dbReference type="HOGENOM" id="CLU_2573857_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="81" mass="8989" checksum="C3ECFAEC605A046A" modified="2013-06-26" version="1">MPSASFAEIDHLPPDLPWVFLRRTRRSSRPLLGAGTSAERGTNIQHMACSCKLLSSRATTARGLYVYQKIAELDQHALKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPI1</accession>
    <name>N1PPI1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF914-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_43652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPI1"/>
    <dbReference type="STRING" id="675120.N1PPI1"/>
    <dbReference type="eggNOG" id="KOG2766">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039639_4_1_1"/>
    <dbReference type="OMA" id="VRYHWAQ"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME45292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="47017" checksum="5AF147E78D1C7677" modified="2013-06-26" version="1">MSKTNGTEQVTEHHVSEFNDEDIEPTSYERITVVPKGTSTTPEASSPSSSRHGHGHGAVELIGGANPSVQPPVQTTVAEVEGGKKRFGYLRRPQFWLVLVLSQALAVTITGTNTLSTLLSNEGTSIPAFQSLFNYVLLNIIYTSYTIYKYGFRGWLKLMYKDGWRFFLLAFCDVQGNYFTVLAYRYTTILSAQLINFWAIAVVVLISLIFLKVRYHVFQYAGILICCGGLGMLVASDHITGSNGGPAADAVKGDLFALVGATFYGLSNVFEEYMVSKRPLYEVIGQLAWWGMFINGVQAGIFDRAAFRAAVWNAKVGGYLTGYTLLLTWFYSAVPVVLRMASAAFFNIGLLTGNFWGVIVGIKVFGYHVHWMYPIAFCLIMGGHFVYYGTEGVLGEAKKPWLGENQEGGNDGIGTARRQLEHPGVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPL8</accession>
    <name>N1PPL8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_33509</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPL8"/>
    <dbReference type="STRING" id="675120.N1PPL8"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OMA" id="VHWPSEG"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="UniPathway" id="UPA00810"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032866">
        <property type="term" value="F:D-xylose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19115">
        <property type="entry name" value="AKR_AKR2D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044487">
        <property type="entry name" value="AKR2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME44883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="320" mass="36164" checksum="276921CA18DD0395" modified="2013-06-26" version="1">MSAPTVTLSNGRKMPLVGFGLWKVNNDTCANQVYNAIKTGYRLFDGACDYGNEKEAGEGVARAIKDGLVKREELFIVSKLWNSFHDKERVKPICKKQLEDWGIDYFDLFIIHFPIALKYVDPSVRYPPGFFDENDKLSLSKAPLEETYHAMEELYDEGLIKSIGISNYNGSLLLDVERYAKHMPQTLQIEHHPYLVQQDLLELCASRKIAVTAYSSFGPQSFLELNMQKAKDAPLLFDHSTVKSVSEKHNKTPAQVLLRWATQRGVAVIPKSNNQGRLAQNLDVCSFDLSDAEIKQISDLDQGLRFNNPLNYGVQVPIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ73</accession>
    <name>N1PQ73_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_72130</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a one-to-one complex with cytochrome c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ73"/>
    <dbReference type="STRING" id="675120.N1PQ73"/>
    <dbReference type="eggNOG" id="ENOG502QR1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036959_1_2_1"/>
    <dbReference type="OMA" id="QRKWNGP"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="16">
        <location>
            <begin position="66"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME44574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="367" mass="41039" checksum="07EB282E9F8F8557" modified="2013-06-26" version="1">MASTGRSFARALRSTPASQPFRSSATRQSIACSFQQQARRGYSNSGSQSPNNSRYIWSSAAAGLSLVVAGYFTLVKKHGPLAEESAKPFTPTKDDYQEVYDAIAAKLIKEDDYDDGSYGPVLLRLGWHASGTYDAQTKTGGSNGATMRFAPEKDHGANSGLHIAQDFLESIKKQFPWITYSDLWTLAAVCAVQEMGGPDIPWRPGRSDRDVSFCTPDGRLPDGSKEQNHLRAIFGRMGFNDQEIVALSGAHALGRCHTDRSGFSGPWTFSPITLTNDYYKLLFDEKWQWKKWGGPKQYEDTGSKTLMMLPTDMAITKDKSMRKWAEVYAKDQEKFFQDFSNVVCKLFELGVPFETDEGTRIRFKRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR30</accession>
    <name>N1PR30_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_170771</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR30"/>
    <dbReference type="STRING" id="675120.N1PR30"/>
    <dbReference type="eggNOG" id="KOG2866">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041037_4_0_1"/>
    <dbReference type="OMA" id="FMGINRT"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="170"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="374"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME45398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="490" mass="55181" checksum="CE532FBA1211B5A5" modified="2013-06-26" version="1">MARLNTRPSTIAGANSPIRGTPALDNNYSDQENEEPEAERPRRDKGKGRASEMSGRSTLPTPDSDTRDTAPARKRKRAEAQSATQAEDIDSDGEVPQDPEDVERFNRYYNPAQDPEQRRQVKRKSRALEREFNEKRDELIKGDGKELSETINRANNVFKTVRQTNDATVDSRLFVNLSSVAQRRSANLVLGDTQTGVDLDVLVSRACYFMQHGEAMNAEDGAAATQRQTQRRRARTEEDESDDDEDLGQPMDWVMFGKHACFPYGRRPACPSFLLGPLSVEKKVRKQTQRTARQTQDKNVRETRPEALTRAELSQSDENGLTAICKRIHRQLEIHCDQMNQKAAETFGSLAEMSTPAGLKWLKEHRITIEGGPSLFDFTLHPNSFGQTVENLFYVSFLIKEGVIGISYDQDGLPVLILTDPTKPGKAREEDAAANRRNKVGNVGNKHQAVFSLDYGTWQDLAKAFNVKEPMIPHRDETEGQVIGDRGWYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRS9</accession>
    <name>N1PRS9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_23189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRS9"/>
    <dbReference type="HOGENOM" id="CLU_1147175_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="242" mass="27315" checksum="F5C43509DA7CF30B" modified="2013-06-26" version="1">MDASIAASQVESNLNLASSLDQQPVHPSINYIGDWSIDNIILAQRKKFNFPFKTLELHALVYAHDINGQPGTYVYLDQREETGAVKYSLPTKRLRIDGSEKWTLGTWARMAASKTKPEMGRLREVDVHMIAPMGGPGEERLRAVALFMGDVMVEMRGDRDGNSIWCGEEMIERSLGESFQQGVWYEVARGFNVLKQEVALSIQDRDGKVMDALPRNEDVNKGSWSPYDGEGAFVRQMTRRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRZ5</accession>
    <name>N1PRZ5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_70987</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRZ5"/>
    <dbReference type="SMR" id="N1PRZ5"/>
    <dbReference type="STRING" id="675120.N1PRZ5"/>
    <dbReference type="eggNOG" id="KOG0001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_0_0_1"/>
    <dbReference type="OMA" id="MSDEHTL"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000004">
        <property type="entry name" value="Polyubiquitin Ubiquitin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME45125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="229" mass="25762" checksum="E428C09C461F7F05" modified="2013-06-26" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS56</accession>
    <name>N1PS56_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thi1</name>
        <name evidence="9" type="ORF">DOTSEDRAFT_42831</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.176" evidence="1"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS56"/>
    <dbReference type="STRING" id="675120.N1PS56"/>
    <dbReference type="eggNOG" id="KOG1406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_0_1_1"/>
    <dbReference type="OMA" id="SMTQFGQ"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="8">
        <location>
            <begin position="266"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME46291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="459" mass="50303" checksum="F4A0C5F17186D320" modified="2013-06-26" version="1">MEIKKPQQNAYVLGVGVTKFIKPRQTRSYVEMGFEAGVKAMLDAQITYDDVEMGVACYCYGDSCSGQRVFYQFGMTGIPIYNTNNACATGSTGLHMARTLVRSGAADCIMVIGFEQMQPGSIKSGWSDRPSPMELSSRMMEQEFGKHDSPRNAQYFANAGREYVELYGANEDDFAEIGRISHEHSTRNPYAQFQQEYSLKEIKDSTMIHWPVTKLQCSPTSDGSGSAVIVSERFLKARPHLMSQAILMAGQQLQTDPPTLYSKSAMDLCGFGMTKNAVQLAYKEAGVTAKDIGVCELHDCFSANELILLEGLGFAEKGKAHELVRNGDITYGGKGPIINPSGGLISKGHPLGATGLAQCAELTWQLRGWANTRHVPAKVALQHNLGLGGCVVINVYKRADGKENKKLSDQEAVKGTNWKYNPATAAKTPSMEEAKKVLSKKFQVEYAMSNTPQLIQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSA3</accession>
    <name>N1PSA3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_78650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSA3"/>
    <dbReference type="HOGENOM" id="CLU_1057778_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="263" mass="27188" checksum="F834F4F491247E7B" modified="2013-06-26" version="1">MRLFGEVGVLYYTALSSAQSASTSVLTDDGNLEQQPRPAVVTKTVHRTCPTTMVYLRSLGWIATNGTTRPSVFSLNSSTTSLLHSNPPDPCSTIEDSALQSTSSAWVSAFLPRSNPAASDAPATQLPGSVSGPPSATGLHSALPVDTSAASFAGTVIDTGGHAASEDVFSTMLATGVACDTRQYSTSSSQASSGAPASLHAMSLPTSATTAATRASESQVAQSESIATSIDDRFFCSIDSIGAFHDPPSQLRTRQLVQAPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU82</accession>
    <name>N1PU82_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_22039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU82"/>
    <dbReference type="HOGENOM" id="CLU_2306017_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="100" mass="11866" checksum="D98A36B577772672" modified="2013-06-26" version="1">MERITRLQQQRAAKQAFINQLRAECGNIESEMTENEATVPMPTFTVRFTKLMALQEPKHVLFEQVMKYDLEEMGEEDIDSKDEYHKAEPREDWKDDDVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUH7</accession>
    <name>N1PUH7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CYTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_22137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUH7"/>
    <dbReference type="STRING" id="675120.N1PUH7"/>
    <dbReference type="eggNOG" id="ENOG502RB34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057907_0_0_1"/>
    <dbReference type="OMA" id="LGLWVRQ"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33840" checksum="D160B9FDF627E510" modified="2013-06-26" version="1">MFLFRIYRIASPGSFSSITGCRTTQRRLLSHISVPVPRSTELEVESKFNVTALLRSRLDGRYPRNEHLNTSLAAATSLLKFTRQPDKLINDQYFDDDDTLCSRGIWVRRRIERTLLSRDFPFQVPVKRSLEWEAKIRVGGDCQSSQFEEVVGEEAVMNLVKQHVSDLASLHKVVDINTLRKAWTVREHVERALADREQRMMVVIDSSTAGGTVVRGPEEESAFHHMVGEVELTLDLELGEDGTKNVMAKRAAAELMKTELDMFMKRNSSLFPTRPAPVGKLTAYFAWKQRQDDRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUX6</accession>
    <name>N1PUX6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUX6"/>
    <dbReference type="STRING" id="675120.N1PUX6"/>
    <dbReference type="eggNOG" id="ENOG502RZ6R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012207_0_0_1"/>
    <dbReference type="OMA" id="MANVAPY"/>
    <dbReference type="OrthoDB" id="3649539at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="672" mass="73312" checksum="037F6CC9BB6720B8" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVW8</accession>
    <name>N1PVW8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVW8"/>
    <dbReference type="STRING" id="675120.N1PVW8"/>
    <dbReference type="eggNOG" id="KOG3337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067902_0_0_1"/>
    <dbReference type="OMA" id="MKFFENN"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="258" mass="28955" checksum="0B6E6C171602D02B" modified="2013-06-26" version="1">MVKFYSSNYSYDYGFSAVSLAYFLRYPNPYSRHVASTDVIDRHFDPVTQRLTTTRLHLKKSRLPPAVLKLLPKKDVGANDDGSTQSFILEHSVVDVKEGWMQTESRNLDWNNVLSVIERHTYERPAFKNAAGDELFAAPGVALPKEEDRTDVAVSVTLKSRIGEQIRKRRERWGQQATAVSVAGGEVSNVDEEPAKQSWFNSWTSGAIRSAIETISLQRAEKSQPKAKKGMTVVLARLQKGGIQAVLEGMRDDREIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW00</accession>
    <name>N1PW00_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_165886</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW00"/>
    <dbReference type="STRING" id="675120.N1PW00"/>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_6_1_1"/>
    <dbReference type="OMA" id="NNMMLFI"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000746">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF81">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
            <begin position="8"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="9">
        <location>
            <begin position="185"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME47103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="349" mass="37418" checksum="0A14EF4660CA2842" modified="2013-06-26" version="1">MAALPKHIGWIGLGLMGYPMATNLIKKTNQHTHFYVYDVVRESVDKFVKEGGDSVHACQSSREVADKSDLIFSMVPEGSHVRSVYLDETSGVLTSQTLSKNKKILIDCSTIDTATSLAVGAACHDQHPSASFYDAPVSGGVKGAENATLTFMLGASESDPNASLLKSLLSLMGSNIFPCGGPSLGLVAKLCNNYTSGMIAIAVSESLNIGIKSGMDPRVLANIYHTSTAQNAICDDWCPAPHVYEDALSSKGYKGGFKVGLMRKDISLAVDTAKSVGAKLALGKEGLGVYEGAAKDEKCKDLDSRVVYRYLGGVEDWKGKANFPEKAEMKRDETRALMKTAKEMEVDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWK8</accession>
    <name>N1PWK8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_69345</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWK8"/>
    <dbReference type="STRING" id="675120.N1PWK8"/>
    <dbReference type="eggNOG" id="KOG2568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024065_1_0_1"/>
    <dbReference type="OMA" id="TWGFYDF"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109396" evidence="9">
        <location>
            <begin position="21"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="186"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="468"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME47378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="546" mass="60686" checksum="9260FA03D750400B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWS6</accession>
    <name>N1PWS6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase-activating protein GYP7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GAP for YPT7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_69807</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWS6"/>
    <dbReference type="STRING" id="675120.N1PWS6"/>
    <dbReference type="eggNOG" id="KOG2197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004457_0_0_1"/>
    <dbReference type="OMA" id="WWREQRG"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000032">
        <property type="entry name" value="GTPase activating protein (Gyp7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="446"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="747"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="782"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME47991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="849" mass="95990" checksum="D9BDD29B84048D91" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWT3</accession>
    <name>N1PWT3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_146121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWT3"/>
    <dbReference type="STRING" id="675120.N1PWT3"/>
    <dbReference type="eggNOG" id="ENOG502QT1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_3_0_1"/>
    <dbReference type="OMA" id="GNLIICE"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="80"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME47453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="289" mass="31997" checksum="1B8B1395D254F7CA" modified="2013-06-26" version="1">MFDGEKQIQRNPHGNFKEVEASRPKWRDDATWTYTQTKNPNWKPGQGANDGGESLEKEHICIDPYEEGRPATFNYKLLISAIIPRPIGFVSTRSKDGSSTNLAPFSYTQVINHDPPVFIVGYAGGFDKQKDSLKNLMDSGECTINIVSEHYLEAANATSVNAPYGVSEWALTGLTPAPCKEVKPSRVKEAVFSVEGKLMNTQEFESRATPGKKTGVLAVIEGVRFWAREDAINEDKNIIDPGILRPMSRLGGITYGRLLEGIEIPRPDWEQFKKEAEPAGLAKPKADGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX39</accession>
    <name>N1PX39_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_33332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX39"/>
    <dbReference type="HOGENOM" id="CLU_1959531_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="128" mass="14356" checksum="FC3BAE2C6EF45DD3" modified="2013-06-26" version="1">MAIQTCRMPTLATNGRASRGEGKRFIVERGLPTTPSTCQSAYTMRRQALAVILQATTAHEDKLPNSDRRHLQPSHQPDCTVDIDEGDTQDTTRERWLHKLRRDGKSLDTSIHLLPHDDVLGDFQIPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX47</accession>
    <name>N1PX47_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_165696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME46990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX47"/>
    <dbReference type="STRING" id="675120.N1PX47"/>
    <dbReference type="eggNOG" id="ENOG502R4JR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041041_0_0_1"/>
    <dbReference type="OMA" id="WHVYNEL"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000011">
        <property type="entry name" value="Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="92"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="410" mass="46006" checksum="9494F0B7DBEAFCDB" modified="2013-06-26" version="1">MGSVEVLRPGPIGQPDIGYAPDLDKYLARVQRRQQAEKLQNTLPEGFPSKLKSDLVWDGTGIAEKYNWTYELNDAEVQEIEDALKHFKSLDKPLGFIDQKTFPLPKLHAALREISDELHNRRGFKVLRGLPVAKHSTEDNVIIYAGVSAHVAPVRGRQDHQFEGKPADVVLNHIKDMSQIVDASKIGAPAYTTEKQVFHTDVGDVIALHCLSEAAAGGESKLSSSWTVYNELARTRPDLIRTLAEPWASENFSGQGQKFTLRPLLHYFPETASAPERMIIQYARRTFTGYWGLPRSSDIPAITEAQAEALDALHFLAEKHAVTLDFKKGDVQYVNNLSIFHARLAFTDTPEKQRHLIRLWLRDPENAWSTPESLKSRWDGVYANVKPENSVFPLQPRIRTQSAGKATPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX62</accession>
    <name>N1PX62_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_21726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX62"/>
    <dbReference type="STRING" id="675120.N1PX62"/>
    <dbReference type="eggNOG" id="KOG3506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177289_1_1_1"/>
    <dbReference type="OMA" id="HCFREIA"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME48012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="56" mass="6592" checksum="0C9B65AF0DA6918C" modified="2013-06-26" version="1">MSHESVWYSRPRSYGKGARECRVCTHKAGLIRKYGLNICRQCFREKSSDIGFTKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXU4</accession>
    <name>N1PXU4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SigF-like NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXU4"/>
    <dbReference type="STRING" id="675120.N1PXU4"/>
    <dbReference type="eggNOG" id="ENOG502S534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079426_0_0_1"/>
    <dbReference type="OMA" id="MSQIFTI"/>
    <dbReference type="OrthoDB" id="2344312at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057514">
        <property type="entry name" value="NTF2_SigF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24840">
        <property type="entry name" value="NTF2_SigF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="SigF-like NTF2-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="207" mass="24348" checksum="BF152C4FF55C8F4D" modified="2013-06-26" version="1">MDDPIQDVADVVHRLTQGSPKQQEEAINEYFTTDASFTHPFCRTGSFEGSRWLIHAIFRWYKVMSPKIDLTVHSVAFDETNLILYINISQVFSIWLVPFHHAHVNLTTVLQLVRKQRKYYIQSQNDLYQADQFIKFPPGLSHMGPLFILFWNFLATFFCVVGAYIGAPFTRYMQRQSEKRNDMGGYANGDAFYRRQQEMIRSKQYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXY1</accession>
    <name>N1PXY1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_21045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXY1"/>
    <dbReference type="HOGENOM" id="CLU_836849_0_0_1"/>
    <dbReference type="OMA" id="ATHINTF"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37528" checksum="9BE1981E7D0826BD" modified="2013-06-26" version="1">MCGDDVAKITLDVDFEADTIELMLALMYTGEYELSTSHYGTTAATHINTFLPNSFEELRCEDYTTTRYLFAQMREHANVFAFGDLYQVIALKSLAVQKFSAAWRRCKAFSTKDFMQIATVIFTRDDYDLCPLRKELIAIAVEHKTALAHNDDFIEAMATRPDFQAFVAPFMKAIASVSLSQAALAPSPTAADSSAQMGTIQRDVEIETANGAPSDVDSLRAEHDKAIASLEDRIKKRDIDVERLRVERDKWVAAHTDAVNKRHIDIALLRASMPTQVQTRQRLRTYLDGLVAAQIPQCGSCERRPFRYSLQWKGDWFRARCIRCGKKHGIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY02</accession>
    <name>N1PY02_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_67456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY02"/>
    <dbReference type="STRING" id="675120.N1PY02"/>
    <dbReference type="eggNOG" id="ENOG502RYM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031559_1_2_1"/>
    <dbReference type="OMA" id="SWIIDNY"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="444" mass="51310" checksum="6FAC13314BEF5C86" modified="2013-06-26" version="1">MVFRRFLPFFLAAGIATILVFTILQGKDVGIPWQIIGLGDSRGPTEEQIKSGKNILPDLRVGNKQEYADFMGNNGNGSGRDWKTFQEPNVENERFYPIGKTKPKGEKYTKGLIMPKMKREDTTWVEEELGDMVDEGVLKSYIYAVDDPSAELRVSKNKGHEVMVYLSYIIDNYESLPDVSIFMHAHRFAWHNNELLNTDAAAMVRALSPERVTREGYMNLRCHWDPGCPAWLHPGSTQKNRDKQEEVILADSWSQLFPLDPIPTVLAQPCCAQFAVSRERILETNKMRYIYMRDWVTRTQLSDYLSGRVFEYIWQFIFSKTAIHCPSMSACYCDGYGICFPSAEAFDEWFKLKYEKGKVQEELRIWKGKAENIETLHKSDSKGRIMEEAALEVPEVGMDRELEGLIEKMENEMERRLREAKERGRDPEMRAKASGRKWRKGDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYM7</accession>
    <name>N1PYM7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_67549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYM7"/>
    <dbReference type="STRING" id="675120.N1PYM7"/>
    <dbReference type="eggNOG" id="ENOG502R5MY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009253_0_0_1"/>
    <dbReference type="OMA" id="GCFQAVM"/>
    <dbReference type="OrthoDB" id="5377623at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF7">
        <property type="entry name" value="TRP-LIKE ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109701" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="708"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="53"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="766"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="815"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="883"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="936"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="815"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="984"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME48537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113599" checksum="46B4FAF2D1569CAB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYU7</accession>
    <name>N1PYU7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_166445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYU7"/>
    <dbReference type="STRING" id="675120.N1PYU7"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_0_1"/>
    <dbReference type="OMA" id="VINCGPW"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF15">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME47419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="486" mass="54289" checksum="809DD9DCB8ABA37E" modified="2013-06-26" version="1">MGGQELRKDSKIVIIGAGVFGLSTTLHLLKRGYTNIHIFDKQPFDKNHYSEVDGADGASCDLNKIVRASYGGEHMYQDLAFKAMPEWRRWNSELLNCERADLPPTLDPSIPLWHNCGFLRLTKDGLESKEIQTQQNFPNDIKHTQYRVSDPQRRIDAQKEGIPASKIDPFHRLERQLPVDGILDTTAGFVLASRACTWALHLCQESPSVTTHFGPDHGLQSIMKTKNRVSGIVTTGIERHTTDLVLLACGGWTPSLIPEVEHLLETTGGSVLSIQLPPHRKDLWERYSEENFPVWSWNMGSYEVPGESIGGIYGMPRTPEGIVKVAFRGAKWTSYTRHTSSGEALSYPNTDADKIPLEAMRVIRTFVAENMSDLLELDLSNCRLCWYTDSVDNSFLIDYVPGTEGLVVASGGSGHGFKFLPVLGEHIVDVIEGKDTAYTRLFKWRDVPKGKRNGLEEGPNGWRTLDKQKLAGNAQWRQAGSGNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZ34</accession>
    <name>N1PZ34_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_70013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZ34"/>
    <dbReference type="STRING" id="675120.N1PZ34"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="OMA" id="VWEGTSH"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF881">
        <property type="entry name" value="FI07970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="211"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME48263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="383" mass="43246" checksum="DA44E3236BDCB8F8" modified="2013-06-26" version="1">MARPAIHKLELRTALGPVYRDVLDNLPRDCTSDEIPIIDLSPMFLNDIDDRLAVAKQVRLASTTTGFFYVRNHGIEPETIDNARRALLSFFHQREEAKMKVHKSHFKSSINGYSPARTTMISTHDKIDNRQSFSWQYLPKYDPDPKPLNEIPDDVKPCIFGEDGVWDGTTHLEGFKQASLEYWSACLTLARRLVRIFALALELPEDYFDSRVTYPGADGVYNYYPPCTAQDLEDNTCGLGSHTDLQLFTLLWQDENGGLQVLKPGILSHDPYEWIKAVPVPDTIVVNIGDFLMRLSNDAFKSTVHRVYNRTGKERTSMPFFFGLNFNCVEGVIPSCVSEQNPAKYEPISCGDWCQMRFKQESVDFAKANGTSNGAPSAKVVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZH0</accession>
    <name>N1PZH0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_19416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZH0"/>
    <dbReference type="STRING" id="675120.N1PZH0"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_1_1"/>
    <dbReference type="OMA" id="EHAMGNA"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109716" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="29"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="6">
        <location>
            <begin position="460"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME48921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="66246" checksum="791EAECB64948030" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZH3</accession>
    <name>N1PZH3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_39776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZH3"/>
    <dbReference type="STRING" id="675120.N1PZH3"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050438_8_0_1"/>
    <dbReference type="OMA" id="MHERTIR"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="71"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME48408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="185" mass="21110" checksum="394E409CEF77137F" modified="2013-06-26" version="1">MADLDTYDGGDQRNYEDDRDYPARDRSRSPDRDRDGDVRVRDEPSNGRADRDERPAEKNGDDGEHSVNTGSNLFVTGIHPRLSEEEVSRLFEKYGQVEKCNIMRDPHTRESRGFGFVKMVTSAEADAAKEALQGEVYEGRTLSIEKARRARPRTPTPGKYFGPPKRGLPHRSFDPYCPLFPATFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZJ9</accession>
    <name>N1PZJ9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_67475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZJ9"/>
    <dbReference type="STRING" id="675120.N1PZJ9"/>
    <dbReference type="eggNOG" id="ENOG502S2WU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2096810_0_0_1"/>
    <dbReference type="OrthoDB" id="7250310at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="116" mass="12522" checksum="86BCF9D368517A0C" modified="2013-06-26" version="1">MRSPFPITLALCASNTLARRLFQQPVDLSIRNLDILSTEKTVGSPLAHPPAKIIKLDDIVPVIDANGNARCCPIGTVNNGIACVFPESSVCPPGTRLVGSLWYQRGRPAMSHHSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0E4</accession>
    <name>N1Q0E4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_147019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL67 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0E4"/>
    <dbReference type="STRING" id="675120.N1Q0E4"/>
    <dbReference type="eggNOG" id="ENOG502S5F1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_530125_0_0_1"/>
    <dbReference type="OMA" id="DEWVPHC"/>
    <dbReference type="OrthoDB" id="5333655at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024629">
        <property type="entry name" value="Ribosomal_mL67"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184">
        <property type="entry name" value="MITOCHONDRIAL HOMOLOGOUS RECOMBINATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12829">
        <property type="entry name" value="Mhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="200"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME47954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="570" mass="65024" checksum="7D951A1815CB49C0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0F9</accession>
    <name>N1Q0F9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_49466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0F9"/>
    <dbReference type="eggNOG" id="ENOG502RP2D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1194856_0_0_1"/>
    <dbReference type="OMA" id="DRINKEC"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="232" mass="26801" checksum="79681A198DFF8699" modified="2013-06-26" version="1">MSGNMKSSATRPTTRPAQQRRRPRATFFSLPGELRNKIYRLALVKGRTIVLDADQLELLERGDPALLRSNNRVKAEAHRIYFEENMFRFTNESLTSSGITTFRLAIGNAYKNLKQISVRRSYQIGDMKPIVIAYHASIQYITERGKKRPKIVIDRPRDEKMPFPGIRSKMRGRCQEPCRCEVDTMARAWQLSDESSGLMLLEFLNEYTERINTAATHAEIQVCRKCNSVRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0H0</accession>
    <name>N1Q0H0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_67714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0H0"/>
    <dbReference type="STRING" id="675120.N1Q0H0"/>
    <dbReference type="eggNOG" id="KOG0737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004223_1_1_1"/>
    <dbReference type="OMA" id="RNCNSHE"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056027">
        <property type="entry name" value="DUF7608"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24581">
        <property type="entry name" value="DUF7608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="805"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME48763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1081" mass="118685" checksum="D2CD27F8EEB7C6C7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q179</accession>
    <name>N1Q179_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_143570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q179"/>
    <dbReference type="STRING" id="675120.N1Q179"/>
    <dbReference type="eggNOG" id="KOG3396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072095_0_1_1"/>
    <dbReference type="OMA" id="NQRYDWI"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME49511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="171" mass="18978" checksum="305A470C24206401" modified="2013-06-26" version="1">MVVEANSLFSPSLISSKVVSDLPEGYSIRPLERSDFDYGFLDVLRVLTHVGEVTKPEFEERFDQMKAGAGGYHVLVILDGDRKIVGTGALIVERKFIHHLGLVGHIEDIAVAKDQQGKKLGLRIIQALDYVAENVGCYKTILDCSEANEGFYVKCGFKRAGLEMAHYYGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1R7</accession>
    <name>N1Q1R7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_122371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1R7"/>
    <dbReference type="STRING" id="675120.N1Q1R7"/>
    <dbReference type="eggNOG" id="ENOG502T2SE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110347_1_1_1"/>
    <dbReference type="OMA" id="KEMMQVM"/>
    <dbReference type="OrthoDB" id="3638982at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110366" evidence="1">
        <location>
            <begin position="18"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="178" mass="18884" checksum="74EF374FD38F1F6E" modified="2013-06-26" version="1">MKSASIAGFVLFGMASAASLPGDSYGDKKRACCPAEIALATGIHLNINGQYSEYNTTQKIEDAEKAHPSGPSTEIYELIGQLQANVQGGQNLRLFNQQIAPAGNPAIPGLAQYAAAEETEKSQADAVLNGNYAHDKPTLEMLKQEILKGITLNQNNLKAAVSECDFTLVFPPANEMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2D6</accession>
    <name>N1Q2D6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_41025</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1Q2D6"/>
    <dbReference type="eggNOG" id="KOG0245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_20_0_1"/>
    <dbReference type="OMA" id="IDRGAKC"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000021">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="8"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1525"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="612"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="771"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME49877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1625" mass="181789" checksum="B1EA13A14D7F8B6B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2L5</accession>
    <name>N1Q2L5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation machinery-associated protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_76779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMA20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2L5"/>
    <dbReference type="STRING" id="675120.N1Q2L5"/>
    <dbReference type="eggNOG" id="KOG2523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090468_0_0_1"/>
    <dbReference type="OMA" id="GVENIHY"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="90"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME49483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="190" mass="21242" checksum="799DF0C0F65290DB" modified="2013-06-26" version="1">MFKKDFTAGAKSKVKSSAQRAIRAKVIETYPRIEPYIDDILPKKEQVDLVKLPDRVSLYSINGQPLFWQHMDDAIIPHLKVIHKYPWCFTRVRIDRGGIRFVLSGATLMTPGLTSPGGRLPGAKESEEWANDGKEIEEGEVVVVDAEGKENACMVGVLKMGTAEMKEKKKGPAIENGHYVGDGLWKLDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2R8</accession>
    <name>N1Q2R8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_67719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2R8"/>
    <dbReference type="STRING" id="675120.N1Q2R8"/>
    <dbReference type="eggNOG" id="KOG4388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003590_1_0_1"/>
    <dbReference type="OMA" id="NMYDATY"/>
    <dbReference type="OrthoDB" id="5570009at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="219"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="423"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME48769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="687" mass="78252" checksum="1B12A30CBEC763A6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2V3</accession>
    <name>N1Q2V3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_67762</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nup188 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1Q2V3"/>
    <dbReference type="eggNOG" id="ENOG502QQFV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001029_0_0_1"/>
    <dbReference type="OMA" id="HSWKFFA"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018864">
        <property type="entry name" value="Nucleoporin_Nup188_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10487">
        <property type="entry name" value="Nup188_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal" evidence="11">
        <location>
            <begin position="176"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="13">
        <location>
            <begin position="743"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="13">
        <location>
            <begin position="1064"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="12">
        <location>
            <begin position="1479"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="888"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="888"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME48814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1855" mass="202852" checksum="F545EACC7F8D6F74" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2Z3</accession>
    <name>N1Q2Z3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 24 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_67920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2Z3"/>
    <dbReference type="STRING" id="675120.N1Q2Z3"/>
    <dbReference type="eggNOG" id="ENOG502S6UW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1214727_0_0_1"/>
    <dbReference type="OrthoDB" id="5358886at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051018">
        <property type="entry name" value="Bacteriophage_GH24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002196">
        <property type="entry name" value="Glyco_hydro_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023347">
        <property type="entry name" value="Lysozyme_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38107">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38107:SF3">
        <property type="entry name" value="LYSOZYME RRRD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00959">
        <property type="entry name" value="Phage_lysozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="2" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="228" mass="25364" checksum="9337EFA8DAE7E89E" modified="2013-06-26" version="1">MINFIKSLEDSEATSLYDVAGYRTIGYGPGCETDGCTEATLVLLDGSSRRRSVACRRCQGEHNLGVVSVRGRRSSQQFELCFGSADSSVRLNANQYGVLVSWSWNVGCGIMRSCTVVGRLNARENPNKLVATRELPKWNLAGERKFPGRGRQKEVQLFQARNESLTCQAIMLLRCTNHPKTDHCLVVDWAQAGAILRRQILLQSSTAQFLEADSHSMPMARFCIRSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q342</accession>
    <name>N1Q342_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TspO/MBR-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_41322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q342"/>
    <dbReference type="STRING" id="675120.N1Q342"/>
    <dbReference type="eggNOG" id="KOG3797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091805_0_0_1"/>
    <dbReference type="OMA" id="WSWLFFG"/>
    <dbReference type="OrthoDB" id="8841220at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME50191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22198" checksum="5B5818DF43656579" modified="2013-06-26" version="1">MTTYLPSLTLPSILFEQPAAAILLPVAAGTAVGFATRPRETQKTYLALRQPPLRPPPWVFGPAWTTLYGLMGYSAYRAWSTASSSIDPSKVALAKHGATLYTIQLGLNLIWMPLFFGLRRPIEAAVDIVTLTGVVGYLAYIWGQVDEVSGWCLAPYLGWLAFANYLTFGVGYLNNWDFSNKEATRPAGGKDSTFNNETPKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3D0</accession>
    <name>N1Q3D0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_68027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3D0"/>
    <dbReference type="STRING" id="675120.N1Q3D0"/>
    <dbReference type="eggNOG" id="KOG3436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110381_1_1_1"/>
    <dbReference type="OMA" id="VMNQKAR"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME49150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14572" checksum="54DBDD7C4B7E36B3" modified="2013-06-26" version="1">MSSGKVKAAQLWGKNKEELKTQLAELKQELVQLRTQKIAGGAQSKLNKIHDVRKSIARVLTIINANQRSQLRLFYKGKKYTPLDLRPKQTRAIRRRLSPEEAKLVTEKQKKKQRHFPLRNYAVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3D4</accession>
    <name>N1Q3D4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_67880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3D4"/>
    <dbReference type="STRING" id="675120.N1Q3D4"/>
    <dbReference type="eggNOG" id="KOG1529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_3_1_1"/>
    <dbReference type="OMA" id="NNNWFAS"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000001">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000033">
        <property type="entry name" value="Thiosulfate sulfurtransferase TUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="74"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="215"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME48979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="337" mass="37415" checksum="CDE5DA8EF0C3CD2F" modified="2013-06-26" version="1">MAAAALLRRPVLLGKLPKLHLHRLASHNMTRSFGSYFVTPAELDAALKKNAPSRLSTSPKTIALCASWFLPNDPDKRKGYDVFKEGHIHRARFFDIDNVADTSSPYPHMLPEPEVFKNAMSELGIARDDTVVVYDTAELGIFSAPRVAWTLRVFGHPAVHILNNFRLWKEQGYAVEEGEQQEFERSTYPTPELDSSKVADFAEVKTIAKDHNKEGSEGVHILDARAQGRWKGTDPEPRPGLSSGHMPGSLNVPVPDLLDPKTKTFLPPEELRKVFAQKGVDPKKPIISSCGTGVTATVIEAALIEAGYGDGSRRIYDGSWTEWAQRVRPVDNLIVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3S4</accession>
    <name>N1Q3S4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_145148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3S4"/>
    <dbReference type="STRING" id="675120.N1Q3S4"/>
    <dbReference type="eggNOG" id="KOG2575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008110_2_1_1"/>
    <dbReference type="OMA" id="FQVPPMH"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME50342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="594" mass="66292" checksum="83E1C31597C39A87" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q477</accession>
    <name>N1Q477_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_68353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q477"/>
    <dbReference type="STRING" id="675120.N1Q477"/>
    <dbReference type="eggNOG" id="KOG1156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006686_0_0_1"/>
    <dbReference type="OMA" id="MEMRADY"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010698">
        <property type="term" value="F:acetyltransferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000003">
        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="596"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME49545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="765" mass="87914" checksum="D4B97D119627C8E0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4L8</accession>
    <name>N1Q4L8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Superoxide dismutase</fullName>
            <ecNumber evidence="2 8">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_68526</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4L8"/>
    <dbReference type="STRING" id="675120.N1Q4L8"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_0_1_1"/>
    <dbReference type="OMA" id="HNQFWEM"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="9">
        <location>
            <begin position="49"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="10">
        <location>
            <begin position="144"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME49775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="253" mass="28641" checksum="3D0DE6C7C24B34B1" modified="2013-06-26" version="1">MMQLFNYSIPLLALWQQAGDWMSNTAQSRLDSIQQNLGTSPTAQNSAMSYSVPQLGYSYDALEPHFDKETMELHHNKHHTTYVNNLNNLLKEHSQLNTLNVDDLVTKLNQIPQDKQKGVRNNAGGHSNHSFFWKNLKLGTTLDGDLEVAIKKDFGSVEDFRANFEQAATTVFGSGWAWLVSVNGTLQIVTTANQDSPLMGEGVSGAKGIPIIALDVWEHAYYLKYQNRRPDYIKAFWSVVNWDFAKQRFSQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4N0</accession>
    <name>N1Q4N0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trp1</name>
        <name evidence="10" type="ORF">DOTSEDRAFT_144117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4N0"/>
    <dbReference type="STRING" id="675120.N1Q4N0"/>
    <dbReference type="eggNOG" id="KOG1223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_1"/>
    <dbReference type="OMA" id="GCVGYLD"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005950">
        <property type="term" value="C:anthranilate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="9">
        <location>
            <begin position="42"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="8">
        <location>
            <begin position="233"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME49795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="539" mass="59212" checksum="4835E0C6515A2394" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4T8</accession>
    <name>N1Q4T8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_164680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4T8"/>
    <dbReference type="STRING" id="675120.N1Q4T8"/>
    <dbReference type="eggNOG" id="ENOG502RNPW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_1_1_1"/>
    <dbReference type="OMA" id="HGGAIPM"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="83"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME49885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="185" mass="20653" checksum="F3A1C861D09A1C2B" modified="2013-06-26" version="1">MTTKIPGQDGTLSQPQATKLMQFYIDSHAKSIPKDNFDRPLYESLQVLDCTLHSPGITAKSTIRLKVPPNLSNQQEGKTPRNTHGGAIPMMFDLPTSITIVACNFSNWESTGMTRRLDVTYLKPPVEGDDVILESEVLNIGKRLATIRGVLKRERDGVVLAVCQHDKYMGDRAHYVGEKWDVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q563</accession>
    <name>N1Q563_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_98045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q563"/>
    <dbReference type="STRING" id="675120.N1Q563"/>
    <dbReference type="eggNOG" id="ENOG502S4VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042937_1_1_1"/>
    <dbReference type="OMA" id="CTQANPE"/>
    <dbReference type="OrthoDB" id="3925971at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109899" description="Complex 1 LYR protein domain-containing protein" evidence="2">
        <location>
            <begin position="36"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Complex 1 LYR protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME50185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="282" mass="32478" checksum="9872D33E53BCECEE" modified="2013-06-26" version="1" fragment="single">MPKFLPPHKSGAHRVAAIALLRALLTQCRRLPVEAQQSNELQNIIRNRFKRHRHNTSHRQLKICFTAGYEAVDLFDDAVAGVAESNRRILDLLQRTPDNAKKPPERGSTKAVEEADRRAKDRAAREEYEAHPKIDLFARPLPLEKLSGKRHVPILFNANHIPVLRLKKPQPHSLSVYINARVMQRQKRHDLRHKLEEEVALAKREDIWDTIVFGFTGVDARKSMDGDGKAVKDPLWMKEPKSALTAVQMLLDKEREKNRVVAEKMQAVVDREQAAFDREERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5H2</accession>
    <name>N1Q5H2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_69014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5H2"/>
    <dbReference type="STRING" id="675120.N1Q5H2"/>
    <dbReference type="eggNOG" id="KOG3745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008002_1_0_1"/>
    <dbReference type="OMA" id="PLCKHHY"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="8">
        <location>
            <begin position="80"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="7">
        <location>
            <begin position="208"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME50339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="884" mass="98619" checksum="037C76F88251BA33" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJ69</accession>
    <name>M2WJ69_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_39203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJ69"/>
    <dbReference type="STRING" id="675120.M2WJ69"/>
    <dbReference type="eggNOG" id="ENOG502QQCH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109471_0_0_1"/>
    <dbReference type="OrthoDB" id="10253390at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473">
        <property type="entry name" value="BTA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21121" checksum="3297F5826449BC10" modified="2013-05-01" version="1">MDSVNLWWSQILNYNYGVQTLDPVANETLMSEDNHYYLVCLLGHYTRRCHPTYLVPKSYLKLSAPSALDNLRIHTDELSEVFACITPETLTIAVLMDSMDWFTPGGPEAPAQCRAINRALKLGGRVLIRSAALSPWYMRVFEECGFSPKRVAARVPPGTCTDRVNMYASTWICTKTESLPLEEQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2WKY3</accession>
    <name>M2WKY3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_28767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WKY3"/>
    <dbReference type="STRING" id="675120.M2WKY3"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_16_0_1"/>
    <dbReference type="OMA" id="HMPKDYP"/>
    <dbReference type="OrthoDB" id="544277at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="109" mass="12096" checksum="E36091902376D0C5" modified="2013-05-01" version="1">MAQQRLTKELHDIESNPPKGISAAVMDEDVFEWLAKIEGAPGGQNYDLSLHMPKDYPSSPPKIGLVTKVKHSKVDANGAIDLEVLTKEGWRQSGTVRDVLEEIRDMLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2XG60</accession>
    <name>M2XG60_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_75962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XG60"/>
    <dbReference type="STRING" id="675120.M2XG60"/>
    <dbReference type="eggNOG" id="KOG2785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018787_2_1_1"/>
    <dbReference type="OMA" id="LNIMEHY"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME38056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="407" mass="45431" checksum="D1A3023EF5FE9EFC" modified="2013-05-01" version="1">MIVNRIAFSGRSGSHGLNESRKGCASRWSTLQCFTMSRQSCNTTLSYTYCLRILNIMEHYCSSLGYRHLSLTTLNMADATVLCSTCNAHFVDNATRRQHMSGAWHVHNMKRRIAELPSILLEQYDGLAQDDHAGRDTPNESVAWLPEAEQSDTVAFDQPESNGDDTATSPQCLFCLVASKSLTENLDHMATTHGFWIPHLDQLETDVETLLAYLQLVIGRFHACLYCGHEKQSAEGIRAHMLSKGHCMLDMSPESDFREFWTASKEEDASDSLSPAQRLLSNTEMRTAAGTIITSRHHEQSRLFERARGGSSNEVAIMASSEQTATDDAQQPEQSTSTSTDKSVARRDQMGIVGLSDTQRRNLAVVQKKMVAREQRSRNEARGILEKSGNKTKQKHFKPDVPGRKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2XIE6</accession>
    <name>M2XIE6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Increased loss of mitochondrial DNA protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XIE6"/>
    <dbReference type="eggNOG" id="ENOG502RZTE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113779_0_0_1"/>
    <dbReference type="OMA" id="FWLWIFI"/>
    <dbReference type="OrthoDB" id="5299849at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018815">
        <property type="entry name" value="Incr_loss_mito_DNA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029:SF1">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10311">
        <property type="entry name" value="Ilm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19615" checksum="B11A3BDA5428F27F" modified="2013-05-01" version="1">MAIISAFTLIRAISLFHITAAYFFLTAPKIIADQNVVFILGESMRLPHATALDKPSDASGFIGVLLAFLGIADLTAASMEEGIALHYWLSNVPVRLVFLFVLTAYTYLFKEGGAFGPSSPSFGKVRVGEPLQNSMVFSFGFIEIATWFWIFTSLREDRHEMARKRVESLKAQEDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKI0</accession>
    <name>M2XKI0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_24993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKI0"/>
    <dbReference type="HOGENOM" id="CLU_2263665_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="103" mass="11726" checksum="74444901168CE465" modified="2013-05-01" version="1">MTSNMDTTVPALYETLKTKPCDFLPAQICSSADDWNRHLPMQISLKTLSFEDAPKYRCLCSLWVLDEQHSITINALELPITKNLLGFLRVMRFKPPDGEYCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y420</accession>
    <name>M2Y420_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y420"/>
    <dbReference type="HOGENOM" id="CLU_1786806_0_0_1"/>
    <dbReference type="OrthoDB" id="3856067at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="145" mass="16005" checksum="B5A89FAE004ED37E" modified="2013-05-01" version="1">MSTEDLAQTLLARLNTSGRLSSTTATSLTEAVASAVSSRAESTATTIVHDVFHTAELLKAILLNNNLMDVTSSQRVSKQFQATITGSTRLQDRLWLRPRPSPTMRCQMPTYKCRGKGRVKNFQPKIRPLLSDSKLHSGPSRSYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y5R6</accession>
    <name>M2Y5R6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_72827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y5R6"/>
    <dbReference type="eggNOG" id="ENOG502SYFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_7_0_1"/>
    <dbReference type="OMA" id="CHCGRIA"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME43589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="158" mass="17902" checksum="50F8D02116CA4F56" modified="2013-05-01" version="1">MSSHPAKPSTPWPEETGVWATYNLHCHCGAVRLNVKVSPPFFESEAEGKGTYPVTECDCSYCERQGYQAVHPLQSNVCFTQGQDNLTKYYCGNKQNPHLFCKHCGSVMMTDLTAMGKFLPGDPRYTVNVRMLEDYDSSKLTIQKVEFMKNMPPKYTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJP5</accession>
    <name>M2YJP5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3669 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJP5"/>
    <dbReference type="eggNOG" id="ENOG502S9QG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039531_0_0_1"/>
    <dbReference type="OMA" id="ILHWKAG"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022137">
        <property type="entry name" value="Znf_prot_DUF3669"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780:SF2">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12417">
        <property type="entry name" value="DUF3669"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3669" evidence="1">
        <location>
            <begin position="307"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="397" mass="44972" checksum="0BD0F51B1506CC92" modified="2013-05-01" version="1">MMALPLQVAGDLTSNGLSYLDETFMAQNSVKKIVSRALSTKSYISTGSSQAEREQQQQDLPPELRNIRQIGEGQCGTVLAMTGTGFVLKLAKNNKRDALYNDVVSHLTVTEAFSRLPIEHRPDISVPRYGEYIHPSDELFWNLKIGNLPRGFTKTYALMTERIFPIPAPVREALFDIYAPVQYRSPAEQARQLTDAKNKDCLVRVYLGRRQKRHSASPNFKLRNFEMHVNEMEELSLDTTAFAQSMAQTLSILHWGAQLDANDVEFVLGSAPLVKVPPSAADYKKRGPEDAKYIGQNFNLHARAVGLWLLDFNECQAYPENGEGLAQLVKGFWFNDPYYPRPFSDSAKDEQLWQVFRTAYLKTTEELYKNQLTRAEGFIKEVEEEGKRRAKSGSLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJX5</accession>
    <name>M2YJX5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_179696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJX5"/>
    <dbReference type="STRING" id="675120.M2YJX5"/>
    <dbReference type="eggNOG" id="ENOG502S8P5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_0_0_1"/>
    <dbReference type="OMA" id="GRWYLAH"/>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_bL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="136" mass="15123" checksum="F3EA4C51866DDF5C" modified="2013-05-01" version="1">MSSQTTCAMLCLRCLRAPLESISRSTRQAAPLIRSSSVAQPVQRRSFGVLSSLPSRPTILPARAALPASELQATTLQPTSPPGLSILQVRGAKRDTFKPSHVVRKRRHGFLSRLRTRTGRMILKRRRMKGRNTLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKA8</accession>
    <name>M2YKA8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_83161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKA8"/>
    <dbReference type="STRING" id="675120.M2YKA8"/>
    <dbReference type="eggNOG" id="ENOG502RV50">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676181_0_0_1"/>
    <dbReference type="OMA" id="PSNWKQE"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="407" mass="42909" checksum="7B281486F9F8EDAD" modified="2013-05-01" version="1">MCWVSVKDEEEYYRVPTRRRTVKRVVRNYSPSPPPIRRVSRTYVRRLTPPPGPPMAAYPPAPPSIRPPSAAPPWPAPSKPPTEAPASSKGIQVLNSIVVGIEADMKTQAMQAFCSGSRIIPQASTSPSAAPDPPPSKPGSKPPTEAPAPSKAPSKAPSKAPSAAPDPPPSKPGSKPPTEAPAPSKVPSKAPSKAPSAAPDPPPASKPASKAPSAAPGPPPASKAPSGSKPSTEAPPPSKAPSGSKSGSKPATVAPPPSKPGSKAPSAAPPSTHHRLKSLFAFVEVDMQLESSSSSSSDDVRSRSTHKTGGTHRSSKSSAPGTEYSVHEREREVRRYSRPRDTPPEWETYRYVEAPPPPPFRSHSRSVSRRGGYDESPRRASVDSHGKLRDRIAITDGHGKTTVDWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKH8</accession>
    <name>M2YKH8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_139159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKH8"/>
    <dbReference type="eggNOG" id="ENOG502S1EZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056292_1_0_1"/>
    <dbReference type="OMA" id="IIPDREH"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="32317" checksum="DF4A4D883DAD7DF2" modified="2013-05-01" version="1">MTELGVIIRDLDDHITTFSTPFYRFAPFGYRKFCAVGNRATAIRLSDGKVLLLNPIQLDQQIERKLTSLGGVHYIASDLGHHLYISQYTSRWPEAKTIGVPGLASKRKDVHWDFINGAEGQSLTPEDAFNFTSDIETVLFTGFITHAVAWYHKESRTLIQSDLMMNLPCTEQYAPSSSHCGLFSQLFGQQANPWSVWFRVLIYYVASVNYRLMRQDVKRVVEWEIDRVIPCHGDVFEERCEEAWKSVYKWFLEGNPERGVLWRFKEPFMRQMQRAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2YMJ3</accession>
    <name>M2YMJ3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_25176</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YMJ3"/>
    <dbReference type="STRING" id="675120.M2YMJ3"/>
    <dbReference type="eggNOG" id="KOG3214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105983_0_2_1"/>
    <dbReference type="OMA" id="YLDCKIC"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="100"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME43201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="152" mass="16379" checksum="45680DD8E8134BBB" modified="2013-05-01" version="1">MHEANATRYVVSETTMGKRKKSSRGPVKKQREVLATSFKCVFCNHETSVGVKIDKKAGVGNLHCKSCLQNFQTGVNYLSQPVDVYADWIDACDAVAKETAGTSAAAPASAHRQPQQPHARAGLAPGEKYTAEDDGFIDDDDADGEADFADED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2YPJ0</accession>
    <name>M2YPJ0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YPJ0"/>
    <dbReference type="HOGENOM" id="CLU_2346659_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="97" mass="10698" checksum="7960D7F6162D5BEE" modified="2013-05-01" version="1">MSGWMNDSVGGRWEPRQAAEQGVCQQQNPADKMIIVPPRAPVYQTALEPGTKLAVHPHEHLQTAGTLAMLARHHAETTRRGSNIQMCGTNIWRSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBK0</accession>
    <name>N1PBK0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_181593</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBK0"/>
    <dbReference type="STRING" id="675120.N1PBK0"/>
    <dbReference type="eggNOG" id="KOG1377">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_0_0_1"/>
    <dbReference type="OMA" id="SPFFMNA"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000008">
        <property type="entry name" value="Orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="57"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME38437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="240" mass="26072" checksum="BF2219A58FFABE33" modified="2013-06-26" version="1">MATPLPDWKQNLIETTLSAGILTFGSFKLKSNRISPYFFNAGLFCEADLTRSLSRAYAHALDNYSKDNSEFAFDVIFGPAYKGIQLCATTAYALADIDEQRYGRIGHSYNRKEVKDHGEGGLMVGKSLQGKKVVIIDDVITAGTAIREAISMINAQGGTLAGIIVAIDRQEKMPSQAEKEGQPDDGTPRGSAIGEVKRETGVPVLAVLTLEDMIAGLNKLGKQTEVAKMQEYRKQYGASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCK1</accession>
    <name>N1PCK1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_57626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCK1"/>
    <dbReference type="STRING" id="675120.N1PCK1"/>
    <dbReference type="eggNOG" id="ENOG502QUDZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041333_0_0_1"/>
    <dbReference type="OMA" id="TRHDPEY"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22682">
        <property type="entry name" value="Ribosomal_uL24m-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME38583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="348" mass="40608" checksum="ABD3E926308F1D7C" modified="2013-06-26" version="1">MQKIIRRTEKATRVAARQKARQDDHTKKGEAWERNQNRVRVVREQNQAIREDRVNRRIDWESGPLAPRRDVGDRAKTYGAQSMYNMMLPDKDPESRPKWSHIAEGDRAVIIRGRDKGKIGIVGEVNLEKAAVQVTGLNLLDIHLPSWLKQQNDDDRDIISHAQLIPIEDVKLVYPLPDPDTGIPRDVIVDRLQCVNRRFDKSKKEWDEGDRVIPGTNTIIPWPEKADPGYEDNEIDTLRISVEEQTFQPFLIRPPMPLTVVDELRNKYSRFRTRHDYEFRMEKELEDNKEEERKGLIRTMRTPLQELAEFKAAQKAQERRGLTDEQLAKIGEVMAQEQARRGLVVEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDA3</accession>
    <name>N1PDA3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_28221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDA3"/>
    <dbReference type="HOGENOM" id="CLU_1610711_0_0_1"/>
    <dbReference type="OMA" id="GMMDDFD"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="165" mass="18016" checksum="48992858059E8632" modified="2013-06-26" version="1">MNSTPSHGLSLSGAQARAISVQRSEQRLKALSMDQESPQTRQVMSSRSYGTQYLPAHDASLSTAQQSDASSMSPVSNSSPTQASPSAGIQPLATGRRRSKKAKSDRGMQRMLEVAAANEAAVQRLVSMLDDFDRRLRVLEQREPQTESEVYESILSGRYRLPSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDA5</accession>
    <name>N1PDA5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 34 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_27222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDA5"/>
    <dbReference type="STRING" id="675120.N1PDA5"/>
    <dbReference type="eggNOG" id="KOG4748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074018_0_0_1"/>
    <dbReference type="OMA" id="DWIWWLD"/>
    <dbReference type="OrthoDB" id="205108at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="313" mass="35767" checksum="E87B4522B96736A5" modified="2013-06-26" version="1">MPLRSTRKVDVNRFLLIAILALLSYSVFYKNGNPSRSSALTTVQQGAENVVESSKELVTSGGNGAGKGKDTKYAVMSMNTKSNSYDYMAVSSKDRYARKWGYDMLWSWDQQKDGIFKYWDKLEMIANATKATLAGDESYEWVLMIDYDTLITNTSITLDELVEDSLQQAEREGKKRDDIDMIVTPDCFPLNVGAMIFRTTPWTLNLMQEWQAGRLIKNKDGHNPSEQDVLRDFIKSNAHRTADKSVTILQWKMNAFPTEIKCYDNRDPIPWKPGMFLVHFAGAWAHVKEDDPTGVLMKRYYPYIDQADSDVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDW3</accession>
    <name>N1PDW3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_75809</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDW3"/>
    <dbReference type="STRING" id="675120.N1PDW3"/>
    <dbReference type="eggNOG" id="KOG2124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007676_0_0_1"/>
    <dbReference type="OMA" id="HIMLTTS"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="718"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="743"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="838"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="880"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="912"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="944"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="15">
        <location>
            <begin position="233"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="16">
        <location>
            <begin position="449"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME38385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1015" mass="112995" checksum="9B52E5E95EA80355" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEA2</accession>
    <name>N1PEA2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_74125</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEA2"/>
    <dbReference type="STRING" id="675120.N1PEA2"/>
    <dbReference type="eggNOG" id="KOG0036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_2_2_1"/>
    <dbReference type="OMA" id="VISYAEW"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15898">
        <property type="entry name" value="EFh_PI-PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="280"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="402"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="507"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME40444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="600" mass="65632" checksum="66CEEEF8158B150D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEH5</accession>
    <name>N1PEH5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_74320</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEH5"/>
    <dbReference type="STRING" id="675120.N1PEH5"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_0_1"/>
    <dbReference type="OMA" id="VYERMKW"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="64"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="163"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="314"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME40742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="405" mass="43973" checksum="3051B28AAC76C569" modified="2013-06-26" version="1">MSSFASGPAQHAAQTTTPNKPHEMTPDSDALPSKEPQLCPTDSDNLIPSQKGGRSRNIQRQSVEYAVRSGVAGGLAACAAKTVVAPLDRVKILFQANNPQFQKYTGTWSGALKAMRDIYLTNGPSGLFRGHSATLLRIFPYGGIKFLAYEQIRAVVIPGEAQETHARRFAVGSAAGLASVFLTYPLEVIRVRLAWETKTSKRMSVRDICKIIYNEHAPLPKVGVESTNLPKTAVAAVEATQATIKAATPSTGLGNFYRGFTPTVWGMLPYAGASFLTHDAAGDFMRLPQFAEWTLLPMSERSQKQLAPGKPAPLVWWAELITGAVAGFVSQTVSYPLEVIRRRMQVGGVVGDGHRLTMIEVAQSITREKGFRGFFTGLGIGYVKVVPMAATSFYVYERMKVVFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEJ0</accession>
    <name>N1PEJ0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_74551</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEJ0"/>
    <dbReference type="STRING" id="675120.N1PEJ0"/>
    <dbReference type="eggNOG" id="ENOG502S6S5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047736_0_0_1"/>
    <dbReference type="OMA" id="QMLYDFH"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME41048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="457" mass="49349" checksum="629853A55D7B8600" modified="2013-06-26" version="1">MAQDYSTWLATNVLNEQQNVSYRNLSRALRVHSNLAKQMLYEFHRKQNSKKPGCVHATYVITGTKRPTQTNGVHSQDDGGDSIMRSSPPLPGSSMPQSQDEAPVPTSTRSIMLVKAEHLDQAKELFEHISGIHIYSLQAGGLSDVQVLTECNRKVQTGYASEDPLKEWKQYGTIQNPSVRRRTRKNGPPPAAASVAKPEVVKAKAAATAAAKTSAAEVKAAVKPPLKSETLNDAKGAHSKPVGSMKSQASTIFKSFAKGAAKPKKTNSQGSSAAASPAALPSPAAPAEDGTEDVPMTDFSDDDVDDIGTNLLGEEPDEVKEPTGPTRKERKAALEALMDEEDEPMKDAEAPVAAEEEEAELDEGAIDKPEAEEEPKENVTVENGRRRGRRRVMKKKTVKDEEGYLVTREEAAWESFSEDEPAPKKAKMSASAPSKTMAKKGGAGKPAGNIMSFFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEZ7</accession>
    <name>N1PEZ7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_28066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEZ7"/>
    <dbReference type="eggNOG" id="ENOG502RHP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1713199_0_0_1"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17154" checksum="0BB54CA24D7BAFA6" modified="2013-06-26" version="1">MFSYLDEVSSRTSGSLETAIRSNADSHIQAYWIDAVCVPRSGPERVATLQSSVSGRERETDLIMIVEEPWMRSVWTYQEIVNAGSSTFTTFPLETPWRMEGSELFSTTGKALRDVQKNANLNGWDLARRYGGTSTLEDALADWQIGELLACQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF16</accession>
    <name>N1PF16_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_74504</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF16"/>
    <dbReference type="STRING" id="675120.N1PF16"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="OMA" id="YKGLKMT"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000002">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="18"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME40972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="353" mass="37670" checksum="49EA9FA3F9831ECE" modified="2013-06-26" version="1">MAGQVPEKQWAQVIEKTGGPVEYKQIPVQKPGPDEVLVNIKYSGVCHTDLHAVNGDWPLPTKLPLVGGHEGAGVVVAKGDLVHDIEIGDHAGVKWINGSCLQCDFCQQSDEPLCAKALLSGYTVDGSFQQYCIAKAAHVARLHKDIPLDAVSPVLCAGITVYKGLKESGAKPGQTVAIVGAGGGLGSLAQQYAKAMGLRTIAIDTGDEKKKMCLEQLGSYAFVDFATSQNVVKDVQAATEDGLGPHAVILVAVNEKPFQQAAEYVRPRGTVICIGLPAGAYLKAPVFESVIKMVNIRGSYVGNRKDSAEALDFFRRGLIKAPFKTVGLSELQMVYDLMHKGQIAGRYVVDTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF79</accession>
    <name>N1PF79_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_158947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF79"/>
    <dbReference type="STRING" id="675120.N1PF79"/>
    <dbReference type="eggNOG" id="ENOG502S71G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108574_0_0_1"/>
    <dbReference type="OMA" id="WMMVMAS"/>
    <dbReference type="OrthoDB" id="3930290at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20690" checksum="F6B6CFC12BFCDBC2" modified="2013-06-26" version="1">MARSSVTRERVIVRQSYYWPDWQLNVWIIIMLATGGVLVGVFANFVQVQNQLGKLGIPWIMPFGITVGSLTIIFILLMLLLILQRRLLPGILIIGAFILLVLYLTGLIETAIQLFGPAGDINSKCETFVSNQPSNDLSINTLAWLEQRSICQSWQAVFAFWIVGAVFLVYLIVLASMVAQGGYGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFA5</accession>
    <name>N1PFA5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Survival factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_74353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFA5"/>
    <dbReference type="STRING" id="675120.N1PFA5"/>
    <dbReference type="eggNOG" id="ENOG502QQY3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030205_2_0_1"/>
    <dbReference type="OMA" id="AFWPRCV"/>
    <dbReference type="OrthoDB" id="2590239at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.370.10">
        <property type="entry name" value="AttH-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023374">
        <property type="entry name" value="AttH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Svf1-like N-terminal" evidence="4">
        <location>
            <begin position="51"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like C-terminal" evidence="5">
        <location>
            <begin position="212"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME40779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41351" checksum="9C68BA839E2503DE" modified="2013-06-26" version="1">MFNWVKQTVGLTDANHGPEGIQSVAKQVEQTPFTELTRDDVKWELVNGTNVETKTFYVIGDNGKIGLLSLIYSDVMGVRTTAQFSSKIYASEPGKPHLWASDNLNNVSFSKDKQNLKADKCAIDLSEDGKTYHIKSSTNKTQVVDMKFTQATPGFVAGKNGTSTFGTDPANPWGKMYHKFWPRCNVEGTIMTKEGPVDFKGKGVFIHALQGMKPHFAAAKWNFAYFQTPTYTAIMMEFTTPPSYGETKVNVGGVVKDGEIIFAGASPQLKAEHTEIKGDPDNDWPEPGAVAFTWDGKTQDGRDAHAELKGAITPRTDRVDVMGELPKFVKQIVAGAAGTKPYIYQYTPKLKLKLNIGGEEHEEEGQLFMEATFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFX7</accession>
    <name>N1PFX7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">had1</name>
        <name evidence="2" type="ORF">DOTSEDRAFT_81813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFX7"/>
    <dbReference type="STRING" id="675120.N1PFX7"/>
    <dbReference type="eggNOG" id="ENOG502S2WA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_2_0_1"/>
    <dbReference type="OMA" id="FEEHDPC"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="240" mass="26663" checksum="E56BF2AA29A23F94" modified="2013-06-26" version="1">MPKSVCFDVLGTCFGFEGAIDVIESRLGSRLRSVHADSKSVFFLWFFAAQRDFTYTSLAGSYTPIAAILKATFKRACAVVDVPPEEITDDDVAAVMAEVKRLRPRPGLKNCYDGLRDAGWDVYGVTNGGKETSLTYYELADIQLDGDHLLSCDEIQVAKPDVKVYETAHRHLTKRGLGMEGDGDRWFVAAHAWDLIAARKAGFKTAYLTFEEHDPVTEVFGRFDVYADSMEELLGKLKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGZ6</accession>
    <name>N1PGZ6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-amino-acid oxidase</fullName>
            <ecNumber evidence="8">1.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_27414</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="EC" id="1.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21817"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.3" evidence="8"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGZ6"/>
    <dbReference type="STRING" id="675120.N1PGZ6"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034311_1_0_1"/>
    <dbReference type="OMA" id="DLWELQP"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000018">
        <property type="entry name" value="D-amino acid oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="11">
        <location>
            <begin position="5"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME40810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="389" mass="42029" checksum="1D515A5838DFD9D2" modified="2013-06-26" version="1">MGSNIVVLGAGVSGLTTAYLLAKNGNHNVTIISKHMPGDYDIEYASPWAGANYLPMPPPAPTLIDKSVAKPGSPSESYERNTWPALERLARDMPESGVHFQDTYIYRRAKDRGTPIEDWFKELIRPDAWFKDVVPNYKNLSPSECPPGSDGGTSFTSVCINTALYLPWLTSQCLKLGVKVRRGVVSHISDATKLHHSGRPAELIINATGLSSLKLGGVEDKNLYPARGQIVLVRNDPGNFMGSTSGTDDGPEEAVYIMHRAAGGGCILGGCLQKDNWESQVDPNLATRIMKRAIELCPQLVPEGKGIEALDVIRHGVGLRPMRTGGIRIEKEVIGAVPVVHNYGHGGYGYQTSFGCAQAAEKLVKEALEGKAESKTEKIGRAQALLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH78</accession>
    <name>N1PH78_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_27510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH78"/>
    <dbReference type="HOGENOM" id="CLU_2084796_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="117" mass="13794" checksum="8205B3CFAC110C16" modified="2013-06-26" version="1">MDNPTALADLRLSRRIKQVREVFPYHSLSYIKHNLGMKRGYLDDTMSWLAMFEDEEAELVGRVQVLSQELQDLVLGFHLHGKRTRRGRMTNRVRVRLPMGKFWEVYQILSVEGYLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH90</accession>
    <name>N1PH90_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_73935</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH90"/>
    <dbReference type="STRING" id="675120.N1PH90"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020931_2_0_1"/>
    <dbReference type="OMA" id="YHGNTNY"/>
    <dbReference type="OrthoDB" id="3519933at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME41702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="508" mass="56896" checksum="99B153C421C89F0D" modified="2013-06-26" version="1">MSPHAVPSTDVSSYGSPTFSSSDVPDLVETRDSNLQRCADDEVHDLVCVGFGPAALAIAVALHDSLESRGSRLSTRSPRVRFLEKQDHFAWHAGMLLPGAKMQITFMKDMAILRNPQSEFTFLNYLHKKDRLVAFTNLGTFLPQRIEYEDYMRWCAQHFDEVVDYSQSVQSVNPGKINDKTGAVEYFNVSSTDSHTGKSQTVKAKHVVIAAGGRPNIPRSLPQNHPRIIHSSQYATHIHKIFPEGTRPRTVAVIGGGQSAAECWHDIPSRFPGTQSVLLLRGSALKPSDDSPFVNEVFNPEKVDDIYSQDPSIREAQIKLDKATNYGVVRIELLEQIYNEMYTYQLTHQSEEDWPHRLQNFRSVTGTREITIDGKPAIELQIQNNSGLYCANKESRQETLAVDLVVVASGYVRNAHEEMLEGLRDFMRGGYADGKSWTVQRDYAVDFEPGTISEDAGVWLQGCNEKTHGLSDSLLSILAVRGGEMVQSIFGYSQDNPKRRVEQSFQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHF1</accession>
    <name>N1PHF1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_47001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHF1"/>
    <dbReference type="HOGENOM" id="CLU_1938116_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="130" mass="15158" checksum="9199DA6149B3AC12" modified="2013-06-26" version="1">MQVHCEFMARRPIERSLQPSPASYSKPVSIHHGRGMWKQEVDRAGSKPDVDMASHIIAKYAESPRIRLALQSHSQWARKRNTTRDCWRCSQHVEPLAAREPRDHCAWFAWRTRGETRHPGTYSTMVYGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI08</accession>
    <name>N1PI08_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PI08"/>
    <dbReference type="HOGENOM" id="CLU_2223214_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="106" mass="11401" checksum="D8C7E1E6296D071B" modified="2013-06-26" version="1">MPANRSVACPSRGWPRNKGNTLSTFPILNIGAAYTRSSLILAANGSAFLDAVKHVRCRSRAVSRYIRAHNVGLSCKQNHGRATVDCGRLWSMVSGTITLLSTSLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIA1</accession>
    <name>N1PIA1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ADP-ribosylation factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_90592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIA1"/>
    <dbReference type="STRING" id="675120.N1PIA1"/>
    <dbReference type="eggNOG" id="KOG0072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="OMA" id="MGAGMSW"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000624">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME41854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19841" checksum="B4A9B5F44EB198A9" modified="2013-06-26" version="1">MGGALSLFTKLLWTKKEIRILILGLDNAGKTTLLYRLKIGEVVTTIPTIGFNVESVVYKNLSFNVWDLGGQTSIRPYWRCYYSNTAAVVFVIDSTDVERLETASGELKAMLQEEELRDASLLVFANKQDQKGAKGAGEISEALGLGELKDRNWSIVGCSAVTGKGVEEGMDWLVQTVGENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIG4</accession>
    <name>N1PIG4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_134541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIG4"/>
    <dbReference type="HOGENOM" id="CLU_2960719_0_0_1"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME41330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="59" mass="6007" checksum="F60455F147E5DA0A" modified="2013-06-26" version="1">MPKRRNNLQRAEAAGANNVEQVGPCAAAIVAGTVAGLSPAVLNGTALAFLAIRIMYNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ81</accession>
    <name>N1PJ81_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_81868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ81"/>
    <dbReference type="eggNOG" id="ENOG502SQ6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077197_0_0_1"/>
    <dbReference type="OrthoDB" id="4232400at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="254" mass="29126" checksum="1DF22A91999B2F02" modified="2013-06-26" version="1">MAPTGDAYEVDWVLSTSSNFHIANHRDWFVNYAPIETFFEHAYACSTKFNALGLGDVKLEVRTDKTAEAYRTLTLNNVLYCPTSSVNIIGEPIFDKFPQWSTHDLRSDGGEVGMIFDNIRRTSGEPVRQKVWLKGHRRGYSSQDANTVGLTSAVWSQEAVLGCKVELQGRSQATSGRERSSSQSKPEDQDQRYTQVEQNWLKEHYESEYLFLRAHMLSIYKQEDRDEGRDLVRVMMERDPASHVCKRRRVSGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJF1</accession>
    <name>N1PJF1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_81483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJF1"/>
    <dbReference type="STRING" id="675120.N1PJF1"/>
    <dbReference type="eggNOG" id="ENOG502T0XX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1069672_0_0_1"/>
    <dbReference type="OrthoDB" id="4509729at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="260" mass="29033" checksum="613B88CE3A87CEFA" modified="2013-06-26" version="1">MLHTLCSKIVSSHHVIIGVSLVRPHLVSATENRLQPRFLTGGTLIVADLKRTRHNMDHKPDHAMPATLFKPTTGRNTSSKRAVMLQHYLAIDTGQLDNTVPDCDTVSLSTNSTMGASPEMSSSEPSSARGSPILTSTQFSQISPPAYALPRPILRKHSSKSPEVATIPENDSLDEFELPNHEQSKHYNIDHDLKTTLTDLLNCDAVRSDPKLRLSIQSRLMESERELKRQRRCRQRQTSLPTPTIVLSRAEDEHRRGSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJG8</accession>
    <name>N1PJG8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_175727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJG8"/>
    <dbReference type="HOGENOM" id="CLU_1713210_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="153" mass="17679" checksum="6AE0D763EAB67197" modified="2013-06-26" version="1">MSMWCDVLDDDIRGKPRQMAPSLVAREQFLKNKAEMLVKPGFYLREQTNVTRTRTWSTWCAMRLDMFEQMDREAGELGTMKIEEAHTFGDKGFNQRLTEFIQTLAAYLGIETILGLLMILAGTGFEIHKSISQNKSRKNSVRSGRLSREQRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJH1</accession>
    <name>N1PJH1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_26646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJH1"/>
    <dbReference type="STRING" id="675120.N1PJH1"/>
    <dbReference type="eggNOG" id="ENOG502QQ4I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035063_0_0_1"/>
    <dbReference type="OMA" id="DCKPAIT"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="25"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="355" mass="39980" checksum="D4276F96A34D882B" modified="2013-06-26" version="1">MHCKPAICSHSLGRAWVHDLPSKLDQAARYGLDIELFYEDLLYIAQEFPGGATPENHIKAAHEVRALCDARGISIICLQPFMHYDGLRNREKHAERVEEMKLWIEMAHILGTNLIAVPSTCLPDEYVSGDMDLITQDMIEIADLGASEGIEFAYEALCWGTHVDLWEQAWEVVCSVNRPNFKICFDTYNFAGRVYADPTRPSGKGPSAEADMAASLKRLVQKVDVKKIAFVQVVDAERLSEPLLEGHPFYDPEQCPRMSWSRNCRLFYGEEDRGAYLPIKAILKALIVDLGYEGYLSAELFNRSLTEADSDVPEAHARRAAVSWQKMVTDFGIGRKVEASGNQRTTLEQQPRAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJJ0</accession>
    <name>N1PJJ0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_81415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJJ0"/>
    <dbReference type="HOGENOM" id="CLU_1137980_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="244" mass="26632" checksum="93F850A22D19FF93" modified="2013-06-26" version="1">MFDTPADEAPLPVERPSKVFMSTPPSLISMNRGIETSALAENSGRGLLTDNADIDHVRLALEELIVDGLAQPTPSDRERHAELRVGDRGLKWILDAKHTTRSTLIGRSASFALQNTVSQANTSPKFICDWVKVVPVPAFAPFRYALDTNGRLPRKKASLACAGMWLLKGLNRPALPPVTACSQETVMASLKILAMKAHMTERGFGWRIRLHLGLSRRTTSSSHASVGDNLHCKSSRALTTSIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJT9</accession>
    <name>N1PJT9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_177180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PJT9"/>
    <dbReference type="eggNOG" id="ENOG502QQX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001419_0_0_1"/>
    <dbReference type="OMA" id="WETWYRL"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1711"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1746"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1823"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1711"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1724"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1746"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1841"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1866"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1888"/>
            <end position="1898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME41815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1898" mass="212951" checksum="75198D41C555B3BE" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJV0</accession>
    <name>N1PJV0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_54772</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJV0"/>
    <dbReference type="STRING" id="675120.N1PJV0"/>
    <dbReference type="eggNOG" id="KOG1443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022332_4_0_1"/>
    <dbReference type="OMA" id="AYNYVKI"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="129"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="523"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME42399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="556" mass="60960" checksum="01A5A4EF15D4A234" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKM5</accession>
    <name>N1PKM5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_44216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKM5"/>
    <dbReference type="STRING" id="675120.N1PKM5"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024402_0_0_1"/>
    <dbReference type="OMA" id="NVPTIRH"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF114">
        <property type="entry name" value="ARYL-ALCOHOL OXIDASE VANILLYL-ALCOHOL OXIDASE (AFU_ORTHOLOGUE AFUA_3G09500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="91"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="584" mass="65675" checksum="4EA019A93F0EE31C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKQ0</accession>
    <name>N1PKQ0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_129278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKQ0"/>
    <dbReference type="eggNOG" id="ENOG502R87D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1590337_0_0_1"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="168" mass="19137" checksum="58A660A26509E19C" modified="2013-06-26" version="1" fragment="single">PVMPTLQDLTAKYHQSSTKTSNNISQVLKLQGFNPLIASTVSKAPVNLDITQKSPSEVEIKQTTTASIPAITEQWTHDWEWREFKDSFLGRVRSRSRWTKAGEVEEGFLQERLEKGAEVVEAEVENVEGKWVARQVWGFEGGDFVRRVVTSNKEGERVETRLVYEVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLM5</accession>
    <name>N1PLM5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bis(5'-adenosyl)-triphosphatase</fullName>
            <ecNumber evidence="6">3.6.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_172363</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="6"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLM5"/>
    <dbReference type="STRING" id="675120.N1PLM5"/>
    <dbReference type="eggNOG" id="KOG3379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_7_3_1"/>
    <dbReference type="OMA" id="DAIYGMM"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015964">
        <property type="term" value="P:diadenosine triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="8">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="5">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME44246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="197" mass="22502" checksum="32ABBB4AE890C642" modified="2013-06-26" version="1">MSFPGRLIKFASFDVTSQVFHVTKHSFAIVNLKPLLPGHILVSPLRVKPHLSDLTNDEISDLFNTVTRVERTLRRVYQSEAFNVAVQDGEAAGQSVPHVHCHVIPRTQGDPGGDDKVHEWLEGEEGNVGEHQEQAKRKAGKWAQDEARKPRTKEEMVQEAKWLREEMQKDDEEPRTVAKEAGIDEDDQALRYMEKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM06</accession>
    <name>N1PM06_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_81413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM06"/>
    <dbReference type="STRING" id="675120.N1PM06"/>
    <dbReference type="eggNOG" id="ENOG502SF16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022827_0_0_1"/>
    <dbReference type="OMA" id="NMPVQAK"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="647" mass="71916" checksum="F728D9BA44DFD00E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMB0</accession>
    <name>N1PMB0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase I damage affected protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_53585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMB0"/>
    <dbReference type="STRING" id="675120.N1PMB0"/>
    <dbReference type="eggNOG" id="KOG4081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109453_1_0_1"/>
    <dbReference type="OMA" id="YKFACNS"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21456">
        <property type="entry name" value="DLC-like_SpDlc1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14885" checksum="D8CC398B4D28EF0D" modified="2013-06-26" version="1">MASNSPIPTSRLRQICADACDTAISTTTVYDHAQTQSWNNTIINSILKALISESSTDKDTPPKYKFIVNATIIQHLSDPRGGQETTGDARKVGRRGMHSASGAFWNNEKDGMWSYKYEGGEGKGMDIVVSVMWVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMU6</accession>
    <name>N1PMU6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_73535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMU6"/>
    <dbReference type="STRING" id="675120.N1PMU6"/>
    <dbReference type="eggNOG" id="KOG0046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015284_3_0_1"/>
    <dbReference type="OMA" id="WQLMRKN"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099079">
        <property type="term" value="C:actin body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120106">
        <property type="term" value="C:mitotic actomyosin contractile ring, distal actin filament layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044837">
        <property type="term" value="P:actomyosin contractile ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070649">
        <property type="term" value="P:formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21297">
        <property type="entry name" value="CH_FIMB_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="143"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="292"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="418"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="559"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME42786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="671" mass="74384" checksum="334F36C95214CAF3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMX7</accession>
    <name>N1PMX7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_23902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMX7"/>
    <dbReference type="HOGENOM" id="CLU_2209952_0_0_1"/>
    <dbReference type="OrthoDB" id="3650889at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="107" mass="11946" checksum="CC005B2F6F6E3B45" modified="2013-06-26" version="1">MVTQTALGMIERAGKEFVEQYPRIAEWDHVLEYLRISMGFNSNMVYLHCRNQDAFAAQTRATACPAGLLCATVSALLRVFAEAAYSFTLKVCEANIGTSEDTYTPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN13</accession>
    <name>N1PN13_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN13"/>
    <dbReference type="HOGENOM" id="CLU_1626999_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="163" mass="18120" checksum="42076FB7C06BD104" modified="2013-06-26" version="1">MEFLVRHQSARGTPLSQTPFAAAVHVLERATTGSGKQRSAQAQQKSSGWMPMSMWPKFPSVRPDPSDDLEILLASYPEISVGTSRSTVEIYDLKSSPVKVEEMWHRDDMSEIMPDGVARATPIAVPPKEYDASLEAVRREVRSMKIGNLSDYWDVSRAAKGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNU6</accession>
    <name>N1PNU6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNU6"/>
    <dbReference type="HOGENOM" id="CLU_2386120_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="94" mass="11090" checksum="BCE8C71109B45713" modified="2013-06-26" version="1">MMCSRRFPARVSERYTAQRLLLRGHPPVITYLSCFRAVQKCIVSARRPRNLRDGQYCTRYRGPFNVLKGKVRWKDATSILRWSRNPDCESVVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP16</accession>
    <name>N1PP16_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Peroxisomal hydratase-dehydrogenase-epimerase</fullName>
            <ecNumber evidence="6">1.1.1.n12</ecNumber>
            <ecNumber evidence="7">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Multifunctional beta-oxidation protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DOTSEDRAFT_71864</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32711"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.n12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.n12" evidence="6"/>
    <dbReference type="EC" id="4.2.1.119" evidence="7"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP16"/>
    <dbReference type="STRING" id="675120.N1PP16"/>
    <dbReference type="eggNOG" id="KOG1206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_18_0_1"/>
    <dbReference type="OMA" id="GKTRWQR"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000410">
        <property type="entry name" value="Peroxisomal multifunctional beta-oxidation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000013">
        <property type="entry name" value="Peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000185">
        <property type="entry name" value="peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ketoreductase" evidence="23">
        <location>
            <begin position="315"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="760"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="22">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00055743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00073871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00081853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EME44184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="904" mass="97580" checksum="0A9EA4A8657B956E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPF6</accession>
    <name>N1PPF6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial carrier-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_72300</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPF6"/>
    <dbReference type="STRING" id="675120.N1PPF6"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_4_0_1"/>
    <dbReference type="OMA" id="NRRMYRG"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="50"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="158"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="275"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME44818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="39409" checksum="BA543E911A4EB155" modified="2013-06-26" version="1">MPISNDGSQQSASKDLSSHTSSPASPSPPANNNTSSILSFQASKDVKRFAKRYRTEISASTSSILSTFAAFPLDFAKSRMQSYETSFLHTVKDAYKMEGLRAFWRGVGPPIFSVTIVRTISFSLYQKTKYALDKSITGLTGQSPLVIANAPGSHPTLATMACFGGAGAAAGAMITTISCPFELTKLNEQLAGKVAREAAMKKGPMPGSGEARPVVDLRSGSWQTARRLVKERGFQGLYAGYRLHLLRDTIGTSIYFMTYESAKQLLGNARGKSATSPYAVVVAGGLCGIVSWACIYPIDVTKTRYQKALLSAGSEKRTRPDIKFFQSGSYRGLGVSVLRSCIINMIFFSNFEFIKKNINALEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ89</accession>
    <name>N1PQ89_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ89"/>
    <dbReference type="HOGENOM" id="CLU_2483332_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="87" mass="9921" checksum="0D0D5786795CEE82" modified="2013-06-26" version="1">MGRADDNPRRPDCLLHKANDKARPKASHFVRPRLKLCDIVWTTIRPLESARSFSSSGRSCSVQQRQQRHASSDAAYPHPRSWASRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQE5</accession>
    <name>N1PQE5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_112674</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQE5"/>
    <dbReference type="STRING" id="675120.N1PQE5"/>
    <dbReference type="eggNOG" id="KOG1381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034879_2_1_1"/>
    <dbReference type="OMA" id="WCMIYDT"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME44595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="356" mass="38390" checksum="9E2ADCAD792804DC" modified="2013-06-26" version="1" fragment="single">HLRHQHRWTTTTSLANHTETTPGATRRDLPAYEAPKTGLLSVLPSSWVPYAELIRLDKPAGSYYLFLPCVFSTLLAAPLCNPIPAPATVAYTTCLFATGACIMRGAGCTVNDLWDRNLDPHVSRTRLRPIARGALTVRQAIPYLGVQLLSGLALLLQFPMECLYYGVPSLLLVGTYPLAKRVTHYPQAVLGLTFSWGAFMGFPALGIDLLSATPALISAACLYGSCVSWTVVYDMIYAYQDIKDDAKAGIKSIALAQEKNAKMFLSVVSGVQTALLAGAGLAVGAGPIYFVGTVGGTAASAAYMLWKVNLKSIEDCWWWFNKGAWALTGGAITLGLTGEYLAHYLGWYESETKGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQF7</accession>
    <name>N1PQF7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_108653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQF7"/>
    <dbReference type="STRING" id="675120.N1PQF7"/>
    <dbReference type="eggNOG" id="KOG1270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042432_3_2_1"/>
    <dbReference type="OMA" id="LASRWWD"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME45183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29872" checksum="3F7BA2DB4D7A3500" modified="2013-06-26" version="1" fragment="single">TNASATDAGHSSVNQEEVSHFNVLAEDWWNPQGSSRLLHLMNPFRHRFIRKCLNSQYDTKSFEQRQLRFLDVGCGGGIFAESAARLPTAKSVIAIDPTPEVIAVAQRHQTHDPLLLRPDRLTYKNIAIEQLPLPDTLSDGFDIISVFEVIEHIQSPAAFLDKVLPHLKPGGWLIGSTIARTNTSWFTTKFIAEDVLGMVPRGTHDWHQYIQPHELREWARGRHDLDVGVGGRGWQTMGVVYVPALGWKEVPGSENWGNYFFGVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQR0</accession>
    <name>N1PQR0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4 13">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_72267</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4 13"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQR0"/>
    <dbReference type="STRING" id="675120.N1PQR0"/>
    <dbReference type="eggNOG" id="KOG0042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_4_1_1"/>
    <dbReference type="OMA" id="PHIVKPM"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="16">
        <location>
            <begin position="107"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="17">
        <location>
            <begin position="521"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="692"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME44759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="724" mass="79623" checksum="21607CBBBDD6F08F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR92</accession>
    <name>N1PR92_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Charged multivesicular body protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_61556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR92"/>
    <dbReference type="STRING" id="675120.N1PR92"/>
    <dbReference type="eggNOG" id="KOG1655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079409_0_0_1"/>
    <dbReference type="OMA" id="GVKQMQK"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME44939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24069" checksum="4E4881F9012C8A36" modified="2013-06-26" version="1">MNRLFGAKSNAPKPSLNDAIGKVDTRIESIDVKLAKLNAELQTYQQRLSRMRDGPGKNAIKQKAIKILQQRKMYEGQKDQLQQQSWNMEQAGMMQDNLKNTMATVDAMKTTQKELKKQYGKINIDKIEKMQDEMADLMDMGNDIQESISRSYDVPEDVDEAELDAELEALGEEVDFNAEFGETEMPGFLAESSGPPQFIDEAPEQNKEKQAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR95</accession>
    <name>N1PR95_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR95"/>
    <dbReference type="HOGENOM" id="CLU_2654483_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="76" mass="8513" checksum="35438B3DF27B6E07" modified="2013-06-26" version="1">MLRAAEVVTVNDRGPSVHLCFTVAMLQVRFYTSGLWLARLAPSFLVCSPSSHCSKCAGREMGFCEQKESDFNSYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRH8</accession>
    <name>N1PRH8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_71293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRH8"/>
    <dbReference type="STRING" id="675120.N1PRH8"/>
    <dbReference type="eggNOG" id="KOG3839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041093_1_1_1"/>
    <dbReference type="OMA" id="GCTADIR"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000095">
        <property type="entry name" value="Lectin family integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110085" description="L-type lectin-like domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="9">
        <location>
            <begin position="30"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME45538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="319" mass="35748" checksum="7C93E42D8AC1A819" modified="2013-06-26" version="1">MALRSTSWITSILLAIWACLASAQESDIKSIPLRTHSLQTPYLDTDMQSRWWDFGGSAVIRADQYVRLTAQQPSQSGWIFTRVPLTATNWEITVDFKIHGTGSLFGDGMAMWVTKERAEQGNVFGMKDNFEGLGIFFDTYKNNRPGVVFPYVMAMLGDGKTPYDQANDGKSNELAGCSARGLRNPDFPTKAKITYFQDKQLTVELMYKKEDEWTKCFEVPNVKLPSVTYVGFSSETGELSDIHDIIKVETKNLYSPSGQTGTGGAAGSKDYSRKKGRPQKARTSGGWLWFFAKFIIFGLVVGAGYVGFTAYRARRRDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRL2</accession>
    <name>N1PRL2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_78445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRL2"/>
    <dbReference type="STRING" id="675120.N1PRL2"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_9_1"/>
    <dbReference type="OMA" id="THPPHLY"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="40"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="451"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="542"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME46027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="578" mass="64130" checksum="C78C7155C3114711" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRM9</accession>
    <name>N1PRM9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_86738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRM9"/>
    <dbReference type="STRING" id="675120.N1PRM9"/>
    <dbReference type="eggNOG" id="KOG1680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_1"/>
    <dbReference type="OMA" id="GWTETAH"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="328" mass="36491" checksum="7D0D148B448C0599" modified="2013-06-26" version="1">MPTGKTAPGSDYVHPPELQELPIPESYADLPFTEIKITNVPESSPEVTPIQLLTLYRPKKYNAFTPTMMRELEHAYTLFDVDDRVKCIVQTGHGRMFCAGADLDTGFVGAEEALTDHRDGGGRVVMAITRCRKPTIAAVQGSAVGIGITQTLPMHIRIAWKDAKIGFVFAQRGLVMEAASSFYLPKLIGTSKTMHLVTTGLTYPANHKLLDDLFTEVLDKQEDVLPRALEIAKGVVENTSAVSTYLMRELIYRGPSSPEATHLLDSRIVYELFSSKDNKEGVKSFLEKRKASFQGSMKDDAPQAYPWWDPINTGNRPVNQGYQFKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRY2</accession>
    <name>N1PRY2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phospholipase A-2-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_71039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRY2"/>
    <dbReference type="STRING" id="675120.N1PRY2"/>
    <dbReference type="eggNOG" id="KOG0301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011791_2_0_1"/>
    <dbReference type="OMA" id="DKCIYYW"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="188"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="375"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="8">
        <location>
            <begin position="504"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="465"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME45179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="788" mass="85508" checksum="CFA30B2628ECFB9A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSA8</accession>
    <name>N1PSA8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSA8"/>
    <dbReference type="HOGENOM" id="CLU_2145799_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="112" mass="12853" checksum="7EB756AB65DF4FB4" modified="2013-06-26" version="1">MARSEHNNTCLVGRVDMKIPSCDHRSSVRTCRRSIRPEHACRFYSLTRAYKHDTRLGSSMTVAFSHAPLCMPRWWRCTMPTTNATLDAPALLRSAEQTVRLAVSPDVFDRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSH4</accession>
    <name>N1PSH4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_168968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PSH4"/>
    <dbReference type="eggNOG" id="KOG2128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000972_1_1_1"/>
    <dbReference type="OMA" id="KGVLVHW"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="230"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="1036"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="752"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME46401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1699" mass="193375" checksum="6263DFBFA3451836" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSI8</accession>
    <name>N1PSI8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyoverdine/dityrosine biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_51518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSI8"/>
    <dbReference type="STRING" id="675120.N1PSI8"/>
    <dbReference type="eggNOG" id="ENOG502SMHH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025510_0_0_1"/>
    <dbReference type="OMA" id="VAFEMIK"/>
    <dbReference type="OrthoDB" id="3647222at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="55422" checksum="AB9AF42ECF7B5333" modified="2013-06-26" version="1">MEGFLTHGSSIYHRLVALYTRQSDGQLLRCTNKHLEQHWDEVRYATQDSFDGKDHASPATQMQLPLRPVIKDTTANGSTSVILLERQNDSHEHILGVLVKVDNTEPNECLDDFFMDLVLRCTQQTVQPCDSQDQSADLDSIEEKVVDLFENSIRNVAPDDQWPTTGRAFFLRQLKHYTRLNSKIELVLPAFPCKSSNPDKVGNDLPDRGEMIALTTLHNFVRSVEDIYKPGAQVLIVSDGHVFSDCIGVEDSMVDAYGSKLREMNETIKNSFEDGGRQRARFQGLSEMLKLQRSDIEGENLADRLELEELKHPIEQIPINDDAETSRRLLMQGFRANTDELRGRIDAKDPSALALYRDFSRFMLEDLQRNEYTEDLSKSKLRRLSSKVAFEMIERNQAYSNMIEMMFPYHLRLSIHAHNNAGPKFGDAAGSHDLLHVPTPWHGCIVELAGHKDLYMTKVEKVEEAIEEKKVIGAWVAPTPQKNQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTA9</accession>
    <name>N1PTA9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_86802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTA9"/>
    <dbReference type="STRING" id="675120.N1PTA9"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_2_1"/>
    <dbReference type="OMA" id="LVTWQQI"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF21">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE (PLP)-DEPENDENT ASPARTATE AMINOTRANSFERASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="21"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="402" mass="44831" checksum="126587180FDB1A7C" modified="2013-06-26" version="1">MAGLDITKIRSHFPALNQKQVFFDNAGGSQVLKEVIDCIVAYLTSNNVQLGASYPVSVQSTDLFTEGSESVAKYINTTPDCVVLGPSTTQLLRNLSISLYDYITPDSEIIVDSSNHEANIASWVQLARDRGCTLKWWHSHSEHKTNPQLDCNVLRALMTENTRFVAVTQTSNILGTINDVKTIAKTVHEVAGALLCVDAVAYAPHRAIDVSDWEIDFYSFSWYKLYGPHIASMYASKSAQKHLRTLGHFFKPSDTLENLLGLAAANYELTASIPEVCKYLESVPWEETSLYEEKLQGILIEYLVSKPDVYQIYGEPTADRRKRVPVISFTVKGKKSKDVVDAIEARSDFGCRYGAMYSNRLCKEVLGLDQVDGAVRVSLLHYNTEEEVKGYVKVLDEVVFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU19</accession>
    <name>N1PU19_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_20775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME46951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU19"/>
    <dbReference type="HOGENOM" id="CLU_689938_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="400" mass="45587" checksum="59CD6C1F939C2047" modified="2013-06-26" version="1" fragment="single">NNAAAEQDQIQLFEGLVENVAACAAGLIPHIEGGLKWEDDEGEQIIVRVWSSAFVPVSLNQIRCLSNIQLWLAKLSQGLTAELDVLEQRPPEEHLKVSSAVHLVKVLFIYMDLATRGVQVLSNQAVHETGLKQFQYGKEHSQNKHTIALQEIQVKLQAAQLENRASEIRSWEHEALKLIRPFENRVVELLKYEQQNKERDEEQRRNQERLDEVERCLRELEQDPDGVRVDSSRATNIQEDVKADLQFLARAASKLENRALEARIKNIEQSVEAIHEICQNSLTSLLKANKENKDALAVAEQRIMTKVTESVNRSFEAQLNEINANIARIDKKADQNKTDLNEFKRTQVPDILVQQREAQKAQNMVTYVTQQLSRESQRADANVKALCENLAKVLAKKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUJ9</accession>
    <name>N1PUJ9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_22662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUJ9"/>
    <dbReference type="STRING" id="675120.N1PUJ9"/>
    <dbReference type="eggNOG" id="ENOG502S6P7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013452_0_0_1"/>
    <dbReference type="OMA" id="FMNFFDF"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="65508" checksum="D945D195B0B4C06F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUM3</accession>
    <name>N1PUM3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_166002</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUM3"/>
    <dbReference type="STRING" id="675120.N1PUM3"/>
    <dbReference type="eggNOG" id="KOG2737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_1_2_1"/>
    <dbReference type="OMA" id="YELRMIR"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF3">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE AN0832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="15">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME47171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="509" mass="56544" checksum="406B4607A269E3A6" modified="2013-06-26" version="1">MSLRFEGGADKYPAKSHARRVADKLNIADGLIILAGTHTANWPNSDMPAPFRQDRYFYYLSGCNEPGCVITYNIERDNLTLWLPPVDSDPRHMLYYGRGSTVAEALAKYDIDDAHYLKPGEHLPAAEEQKQETGCCPVFMISSRLSDFENVSGVKLRMAIDACRVIKDEHEIDLIRRANDITSAAHVKVMEGIHSFKNEAEVEAAYMSVCIARKAKEQAYDPIAGSGSNAATLHYSANVEDFGYGQTIVLDAGCEVECYASDVTRTLPINRMKPGHWPCKEAEDIYNLVEKIQESCIKQMLPGNKYIEITWHAHHVLIKGLLELGLLKGDAAKIFSAGVSMAFLPHGLGHHVGLEVHDVSPVPHPTSPQDRDAYQQYVARTEAAYKQWNPGYISAFSEMDPFQLERFCLALFDKNALQLASVDAPTLEPGMVITVEPGIYFNEPLLEKFLQSPSLSKFVDKEVLKRYVNVGGVRIEDDILITKAGYENLTTAAKGEEMLKVIREAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUW0</accession>
    <name>N1PUW0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_69194</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUW0"/>
    <dbReference type="STRING" id="675120.N1PUW0"/>
    <dbReference type="eggNOG" id="ENOG502RF2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013691_3_0_1"/>
    <dbReference type="OMA" id="WQTIYPN"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109360" description="tyrosinase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="14">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="461"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="677"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="691"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME47152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="759" mass="81185" checksum="AE1BD7730E85F69C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVX4</accession>
    <name>N1PVX4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_69477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVX4"/>
    <dbReference type="STRING" id="675120.N1PVX4"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_7_1_1"/>
    <dbReference type="OMA" id="LSWWFIP"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF13">
        <property type="entry name" value="THIAMINE TRANSPORTER THI9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME47537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="58701" checksum="EB33F64CC469D896" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWB0</accession>
    <name>N1PWB0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_50702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWB0"/>
    <dbReference type="STRING" id="675120.N1PWB0"/>
    <dbReference type="eggNOG" id="KOG0016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_6_2_1"/>
    <dbReference type="OMA" id="FQAIMDF"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000048">
        <property type="entry name" value="3,2-trans-enoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME47263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="276" mass="30446" checksum="28DB1922E902DE49" modified="2013-06-26" version="1">MDAAPKPVDEINFSVQGRVAIIRINQSKKLGALSQDLFFHLSQLMRHINGRDDILITVLTGTGRFFSAGADVSVAGQNSGPKDDQYKQLLQSFAAYNLNITQAFYSHRKILVTALNGPVVGIAAALVGMSDFVYAAPHTYLLCPFSSLGLVAEGLSSRAMLNRLGPSRGPEALLMSKRITCEELVQCGFVNKVFGTKLEQSEEFLQKVLEEVDNRLGEHLVPDSLLRTKALIRGPERDLYDSMGVKEVFSGIEMFMKGVPQEEFRKIASGEKRHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWB7</accession>
    <name>N1PWB7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_42147</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWB7"/>
    <dbReference type="STRING" id="675120.N1PWB7"/>
    <dbReference type="eggNOG" id="KOG2229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009161_2_1_1"/>
    <dbReference type="OMA" id="AMYKTYK"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007089">
        <property type="term" value="P:traversing start control point of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="480"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="660"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="453"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="621"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME47821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="711" mass="79606" checksum="3D513CDFC90DADC6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX28</accession>
    <name>N1PX28_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX28"/>
    <dbReference type="HOGENOM" id="CLU_1299680_0_0_1"/>
    <dbReference type="OrthoDB" id="10675815at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23691" checksum="189DEF34B04BEBC2" modified="2013-06-26" version="1">MASEPEHAVTAADKLSALPVELKTEIFNADTIWICELVSRHFRDIIEESKNEAALSKRGIDEPYMRLKSEAVALLQFSRDSPCAFIPAADAFFRHRGLALDPKIRDGEISLFAAIWEMREQHRDGDSRLEHGVRTVIKTGKLGSIIEDVLMKSRGWHSEGSYDSGFPDISRLHQSPQSERERAMDGQRGLGDEIVQSHPGPRAFPAGQALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXD7</accession>
    <name>N1PXD7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_123190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXD7"/>
    <dbReference type="STRING" id="675120.N1PXD7"/>
    <dbReference type="eggNOG" id="KOG3198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065433_1_0_1"/>
    <dbReference type="OMA" id="NPFKEAM"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.30:FF:000003">
        <property type="entry name" value="Signal recognition particle SEC65 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME48082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="215" mass="23763" checksum="EE4583DC6FF14A3C" modified="2013-06-26" version="1">MNEQDRNKYNREQQEKSKSYQCIYPVYFDTTRSREAGRRVKKEDAVQNPLAREIVEALAKIGEQMNVPLQIVLEPTKTHPKDWANPGRVKVSIKKDGSPISATIQNKHHLYKLISTHLKANPTTEQTPMRLQIQGMPMPKDNKFIPPAIPRGSKIGTVLPLHSPALSGGGVSENFLKDMMAEMGGQLPPGMAGLAGAGGAITDSSQKKVKDKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXI5</accession>
    <name>N1PXI5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">p-hydroxylaminobenzoate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_169818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXI5"/>
    <dbReference type="STRING" id="675120.N1PXI5"/>
    <dbReference type="eggNOG" id="ENOG502SK80">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099539_0_0_1"/>
    <dbReference type="OMA" id="KGMSGWQ"/>
    <dbReference type="OrthoDB" id="2845956at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032345">
        <property type="entry name" value="PnbB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16155">
        <property type="entry name" value="PnbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25555" checksum="6D7381CA0F93CF9B" modified="2013-06-26" version="1">MASDVHAYFFRFLFTSHLCYCVPILLSRLTKTHLAGHNGSPDGVELETHATAKKLASRSLEFLKEVQDFTPGQALEKRLNEHYGPGNEYYEDFCTLIKQGLEEGWVATHEIDGPKYRRGRIMLPCPENLYMSLTAVYFDSKEEYSGQYHKHPYGEINCVVPIDETFELEGLPVGENWRGRGWTSPGPGTHHYPRSRGGRGVAFFFLPSGRIAYDAKPEESQPAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXR9</accession>
    <name>N1PXR9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_123992</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXR9"/>
    <dbReference type="STRING" id="675120.N1PXR9"/>
    <dbReference type="eggNOG" id="KOG0816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071690_0_0_1"/>
    <dbReference type="OMA" id="LEWAENY"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="126"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME47793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="243" mass="26838" checksum="C36558C5621DC36A" modified="2013-06-26" version="1">MPKSKRARVVHTSVVQKKASKEKSATLFAAVQAAADEYAHIFTFSVENMRNNYLKDVRQHFSDSRLFFGKTKVMAKALGTSPEDEHAPGLHKLSPHLKGNVGLLCTNRAPSEILEYFESFVEVDFARAGTVADRTFTVPAGIVYSRAGEVSVEDDVPLPHPQEVTVRKWGMPTRLEKGKVMLDQEYVVCEEGKEMNSHQTALLKLFGVAMAEFKVQMLAYWSAATQDVAEVDSQADAGGVEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYH0</accession>
    <name>N1PYH0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_41711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYH0"/>
    <dbReference type="eggNOG" id="ENOG502RM5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_857951_0_0_1"/>
    <dbReference type="OMA" id="MMFHREH"/>
    <dbReference type="OrthoDB" id="3867271at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="324" mass="35607" checksum="5E11732BAB034611" modified="2013-06-26" version="1">MSCEVASASPFGDPNDWQKVESPNGCLDAIATFNASYSANEGDTVDRQLFSDRSANNECHHNDYAMSSNSLEQTLSSELCPFGEYPADFGQAPSSPYFQSVEQNPAPIYHPSPLRNNAFRRSVSEPPGGSEVQPPPPMMFHREHHYLGKPMPGQGVQLKSLPKAKQQRSHPYQRARRINAPEPPYHPEHRRAHTQPSRGGPTSSPIMMQMPPQYMPRVPTMQEPQYVSSRVCTPIPEAVMTPHIDPALSGPATPAYMSSNARNTLSIPLTVDELRSMIFEVVQKAVADKEEKKDSVAGVSPRNLAASVESVVDKDAEVGKGEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYN5</accession>
    <name>N1PYN5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYN5"/>
    <dbReference type="eggNOG" id="ENOG502QPXG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027163_0_0_1"/>
    <dbReference type="OMA" id="MPIADHQ"/>
    <dbReference type="OrthoDB" id="2589563at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="347" mass="38526" checksum="40CEB1F6137ABFA5" modified="2013-06-26" version="1">MPLPANVVSPVKEEGDGDPHQAGTIPPWVHLNDGDEKVPFLAPTPSVPNTRHYKPPTKYEPGRKWDAYRTAEPGLLSMPIADHQTRWIPFMQSGPNQREYQEEGVVRDAQWMAANTPIFTRGWEEEDDINPQAKAGQTGMQGIAFLGKWLISPERQERTVKFFWRLLLKNAFVPLVFRLTTLAFSAAAAGVAGTILSSVHKVNDDPDPYNQCTPKASTYMGIIVGSVGVPYIAYVTWDEYMSKPLGLRSVAAKTLLLLCDLYFIVFSASNLSLAFSALLDDSWACFDDTQQMVGDFPVQVARSCPDNPGICSKQKALTGVLFVALVAWLLCFSISVLRVVEKLRLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYV3</accession>
    <name>N1PYV3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_123996</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYV3"/>
    <dbReference type="STRING" id="675120.N1PYV3"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="OMA" id="NICGQMP"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME47424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="546" mass="61020" checksum="359EA903690D5102" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYW3</accession>
    <name>N1PYW3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_124416</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYW3"/>
    <dbReference type="STRING" id="675120.N1PYW3"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_1_1"/>
    <dbReference type="OMA" id="ISTHPCL"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000049">
        <property type="entry name" value="Putative uracil phosphoribosyltransferase urg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME47434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="222" mass="23899" checksum="BF1E567BECE25556" modified="2013-06-26" version="1">MSNVHISQHPCVRAKLSQLRSATTNARDTKTLIHEIATVVGVEALAHGLTVQQTGTDQSPLGYEYTTEHVSPSNMTLVPILRSGLSMVDAVQSLLPSPISVHHLGMYREKSTLQPVEYYNNLPYHRAGAESSIAELAIIVDPVIATGSTVCAAIETLRDWGVKRIISISILASQSGLQRASESWPEAVELWVGGVDAETDAQGMIKPGLGDVGDRLYLTMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZB6</accession>
    <name>N1PZB6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_67427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZB6"/>
    <dbReference type="HOGENOM" id="CLU_2049639_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="120" mass="13442" checksum="E807B52690A4AF98" modified="2013-06-26" version="1">MDVPTGHLQCPASKQPIWLLSLAYIWRVRLLHSPWLHASSVRGCSWIWCPVAAVHFSLMTRDCRECGITKCLLRPFLVGVENSCLASASASGWSGLVRSVDLVLLTRWACTRTISWTCNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZJ0</accession>
    <name>N1PZJ0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_48911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nibrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZJ0"/>
    <dbReference type="STRING" id="675120.N1PZJ0"/>
    <dbReference type="eggNOG" id="ENOG502RCD5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007951_0_0_1"/>
    <dbReference type="OMA" id="GIGDHYW"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10980">
        <property type="entry name" value="Nibrin, BRCT2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032429">
        <property type="entry name" value="Nibrin_BRCT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043014">
        <property type="entry name" value="Nibrin_BRCT2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16508">
        <property type="entry name" value="NIBRIN_BRCT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="384"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="473"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="631"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="581"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="784"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="821"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME48428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="855" mass="95141" checksum="300AAFC033B1E6DC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZT4</accession>
    <name>N1PZT4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZT4"/>
    <dbReference type="HOGENOM" id="CLU_2527430_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="84" mass="9482" checksum="44260631CC26818C" modified="2013-06-26" version="1">MDLTKWPSSSARFGVMLLCSFSWRDAVRGPRRAARGGLKLQGTYTPAKCTLCLPQELRRHFVKKGGVRERIDWSVAVKGWRSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZY5</accession>
    <name>N1PZY5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_67890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZY5"/>
    <dbReference type="HOGENOM" id="CLU_1938102_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="130" mass="14834" checksum="A173905CB8F1EE7D" modified="2013-06-26" version="1">MDADNNIRHSVYGSKASPNERTSFQVLKREIDIQLDVIMRRNRKVVSSSTVADDRQVRQMESHQSARSGWHLQPSRRALRRSVLPTTPSAVPPPALTEAMTQIPDDNYCSAPLIPPTDYQTWKHTRVIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0I7</accession>
    <name>N1Q0I7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_163544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0I7"/>
    <dbReference type="STRING" id="675120.N1Q0I7"/>
    <dbReference type="eggNOG" id="ENOG502RCTR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051214_3_0_1"/>
    <dbReference type="OMA" id="MERRFDM"/>
    <dbReference type="OrthoDB" id="2108802at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109760" description="alpha-galactosidase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="5">
        <location>
            <begin position="28"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="324" mass="35108" checksum="D2CA63152D1383D8" modified="2013-06-26" version="1">MQLSILVSLAVSAAPTLADYWKPEAGLRWQIVLSGDLIGPYPASIKAIDGDLYSNNESTWSDLKASGIKTICYFSAGSYEDWRPDAHEFNNQTDLGSPIKGWNGEWWLNTKSDNVRRIMGERMDLARQKGCDAVDPDNVDAYDNENGLGLTEDDAVDYVRFLAAEAHKRNLAVGLKNAGSIVDRVLDVVDFQVNEQCEEFDECDQFRPFIDANKPVFGIEYTKKDDSTPSRKDVEKICTTAAAEGFSTVIKHMSLNDWVVACNITSTARGNSSSTSNGTSIGNSTASTSSSATSATYSSGASVHQRSLGVVGLLAVTGVLCCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0R5</accession>
    <name>N1Q0R5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_69851</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0R5"/>
    <dbReference type="STRING" id="675120.N1Q0R5"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="30"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="175"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="35"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME48054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="344" mass="36208" checksum="FECB0A0A098434EA" modified="2013-06-26" version="1">MFAARKVSQSVLGGAFQRRAFSATAADLSKVVVLGAGGGIGQPLSLLLKLNPRVTELALYDIKGGPGVAADVGHINTKSNVTGYEPTPEGLAACLKGAEIVVIPAGVPRKPGMTRDDLFNTNASIVRDLAKAAAQHSPEANMLIISNPVNSTVPITAEVFKKAGVYNPKKLFGVTTLDVVRASRFISQIKNTDPANENIVVVGGHSGETIVPLLSQSGYELQGAERDEYIKRVQFGGDEVVKAKDGAGSATLSMAMAGARFTESLLKAAQGQKGVVEPTFVDSPLYKDQGVTYFSSNVTLGPNGIEEIHPVGKVTEAEQKLLDVCLKDLKGNIEKGEKWAQANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q187</accession>
    <name>N1Q187_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_96624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q187"/>
    <dbReference type="eggNOG" id="ENOG502T2BZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2365223_0_0_1"/>
    <dbReference type="OMA" id="ARKIAFW"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024316">
        <property type="entry name" value="APQ12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12716">
        <property type="entry name" value="Apq12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="96" mass="11065" checksum="0D6B75D85DE26A3A" modified="2013-06-26" version="1" fragment="single">GLSLTLKAKSYMLPLVDQLSQKPDLATIALLLVILFISLKILNMLYQTAIFWFRMARKIAFWGSLVALALWMYTRGPDGVAADTQYWFETWQGEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q254</accession>
    <name>N1Q254_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_164593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q254"/>
    <dbReference type="eggNOG" id="ENOG502SUWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128883_0_0_1"/>
    <dbReference type="OMA" id="WGHNYAV"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME49841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17289" checksum="D08F3A0E76EFD2D3" modified="2013-06-26" version="1">MADSDLYNTLETTAMRFITSLSPATRSGNEPNRTGILSNLATNFQSDFGHKVFVSSKPHLQGQKSGQDFVNRMSFMAPKLETWRIDITDVMVDSRRQRAMVRGDFHMTVKGGQTVVNDLVFLVGMDEEGRKVVKVTEFVDAEAAGEIARLMRGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2B9</accession>
    <name>N1Q2B9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_67734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2B9"/>
    <dbReference type="STRING" id="675120.N1Q2B9"/>
    <dbReference type="eggNOG" id="ENOG502S7T4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015973_1_0_1"/>
    <dbReference type="OMA" id="EQDMAFT"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11392">
        <property type="entry name" value="bHLH_ScPHO4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="590"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="724" mass="77527" checksum="71C11326CB24CD31" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2K8</accession>
    <name>N1Q2K8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_68715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2K8"/>
    <dbReference type="STRING" id="675120.N1Q2K8"/>
    <dbReference type="eggNOG" id="ENOG502SK6S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043314_1_0_1"/>
    <dbReference type="OMA" id="QYSAPYR"/>
    <dbReference type="OrthoDB" id="5425848at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF10">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110385" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME49986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="39524" checksum="90EEAB7CA3E60AC3" modified="2013-06-26" version="1">MRFHQTPRPLLQLITTILLAPRHSLAFPNVGFELDDLFARDCTPCGYYNQLCCTAGQTCGTDSAGEAVCSAGQVTAAATASNGYWQYITSTYVETDLVTRTTVMSTYISGAATTGIACNYANNETPCGSICCASGQYCFSAGQCTAAAGGGSSGYYSSYTTPGATAGAPIRPTSSGNTVVTATHTPTTTVAFIAPVSTGANITLTNSEQSGGGGLSGGAIAGIVIGVLAGLFLLGLLCFCCCIKGLLDGLLACFGLGKKRRNRRTEVEEYERYSHHDSRHGGGRTWYGAARPPARVDRTSRNSDHNKSKGILGVGAGLAALWAILGLKRRHENRRDEKYGTEYSYSSDYYTSSSSTSSDDRRTRTYGGRSQSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2L1</accession>
    <name>N1Q2L1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_50096</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2L1"/>
    <dbReference type="STRING" id="675120.N1Q2L1"/>
    <dbReference type="eggNOG" id="KOG0433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_7_2_1"/>
    <dbReference type="OMA" id="HCWRCKT"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="87"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="816"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="719"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME49932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1113" mass="124056" checksum="124A70AB8AC75E4B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2R4</accession>
    <name>N1Q2R4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_67715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2R4"/>
    <dbReference type="STRING" id="675120.N1Q2R4"/>
    <dbReference type="eggNOG" id="KOG3607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012383_1_0_1"/>
    <dbReference type="OMA" id="YGLQQNF"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109837" description="Disintegrin and metalloproteinase domain-containing protein B" evidence="7">
        <location>
            <begin position="23"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="721"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="9">
        <location>
            <begin position="280"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="8">
        <location>
            <begin position="533"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="754"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="786"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME48764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="833" mass="88437" checksum="44871CF74D241A5A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q334</accession>
    <name>N1Q334_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_19395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q334"/>
    <dbReference type="STRING" id="675120.N1Q334"/>
    <dbReference type="eggNOG" id="ENOG502S3VG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_816417_0_0_1"/>
    <dbReference type="OMA" id="REHISIM"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560">
        <property type="entry name" value="BLL0132 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560:SF3">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109284" evidence="1">
        <location>
            <begin position="21"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="340" mass="37292" checksum="8CC57A1DF46B05F5" modified="2013-06-26" version="1">MREPLLAVGLAASLYTSVQAQQFSGNVIPNSLSSVPGSETSYFRISNGSEKKNNLTLINCYSYGQNNQRIVASNVRRAVIMIHGLNSDPATYMSNMRSALAQVNSEPNVNFDNVALMAPFLPSGDDKTTGYSWTNGLATGQGSTGSALIQKGSQWSAGGNHQYPDSSKTTSPYTVLYRIIQYFHNAALFPKLTQIVISGHSLGAQTVQRYAPIGSQLNTWTPQSYWLANPDSHVWLSTDRPLSTACCSIFDDYRRGFDKFTDYPMTYARTLVASGRAAISAYCNSKAINYVRVIQDLSDDSSTCAPETTGKDRNERLIKTRPFSRDARSRQVVVAIHSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3D7</accession>
    <name>N1Q3D7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_68905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3D7"/>
    <dbReference type="STRING" id="675120.N1Q3D7"/>
    <dbReference type="eggNOG" id="KOG2295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014487_0_0_1"/>
    <dbReference type="OMA" id="FEDKIMQ"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="820"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME50192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="879" mass="99850" checksum="2FA49C36E605310B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3G6</accession>
    <name>N1Q3G6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_69007</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3G6"/>
    <dbReference type="STRING" id="675120.N1Q3G6"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_7_2_1"/>
    <dbReference type="OMA" id="LVFYIRH"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="285"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME50331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="631" mass="71161" checksum="90C29CF85213C0EA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3Q5</accession>
    <name>N1Q3Q5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_165457</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3Q5"/>
    <dbReference type="STRING" id="675120.N1Q3Q5"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_3_1"/>
    <dbReference type="OMA" id="MYVCYGA"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="123"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="216"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME50317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="330" mass="35895" checksum="4B3F9A4232AC047A" modified="2013-06-26" version="1">MSTPPAQTRDEGTRTQVVLAGAISGLIARFCIAPLDVIKIRLQLHYHSLVDPLSTPLRQNPTPTGIYLIVQDIWRNEGITGFWKGNVPAEGLYLGYAAVQFLTYRSVSQALDKVEEDRGVKVNGTVKSFIAGAVAGTAATTTTYPLDLLRTRFAAQGTQRVYTSLVSSIRDISRHEGISGWFKGLNAGIGQIVPYMGLFFALYESLKPPLSTMQLPFGSGDAVAGIIASILSKTAVFPLDTVRKRLQVQGPTRKRYIGGERIPVYERGVVGTLGMILRREGTVGLYRGLTVSLVKAAPSSAVTMWAYERALGVIMRMGEKNEAGADRMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4M7</accession>
    <name>N1Q4M7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DOTSEDRAFT_68549</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1Q4M7"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000709_0_0_1"/>
    <dbReference type="OMA" id="HNRRFVG"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000664">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000139">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001008">
        <property type="entry name" value="Serine/threonine-protein kinase cek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="15">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="759"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="1185"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="1551"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="303"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="558"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="605"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="916"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="976"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1224"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1323"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1668"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1751"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1776"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="983"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1021"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1040"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1323"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1356"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1404"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1464"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1673"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1694"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1711"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1777"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1801"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1832"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1850"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1867"/>
            <end position="1877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EME49790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1963" mass="213687" checksum="3D03F5EE000ABA2A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5E4</accession>
    <name>N1Q5E4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_68929</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5E4"/>
    <dbReference type="STRING" id="675120.N1Q5E4"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028929_1_0_1"/>
    <dbReference type="OMA" id="FKDHQFT"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000001">
        <property type="entry name" value="Sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME50214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="567" mass="61911" checksum="CDA5BB82A0C712F5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5H6</accession>
    <name>N1Q5H6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_85537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5H6"/>
    <dbReference type="HOGENOM" id="CLU_2084783_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME50359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="117" mass="13560" checksum="C23C15245B348528" modified="2013-06-26" version="1">MSSTILAVRRSAPVHVQLLREPRVHLLMLCSLLRATGTTSRLARQCLHARRLRTCARRVMWNAELRHQRSMRVLSARQMRHRMQTSAGWSGRRTARLDTLFALLFTTRDDRSLALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5I0</accession>
    <name>N1Q5I0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5I0"/>
    <dbReference type="STRING" id="675120.N1Q5I0"/>
    <dbReference type="eggNOG" id="ENOG502T9C2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_505283_0_0_1"/>
    <dbReference type="OMA" id="GHMNFAL"/>
    <dbReference type="OrthoDB" id="3642326at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="539" mass="59508" checksum="DEDF410E470C1BCB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>M2WK03</accession>
    <name>M2WK03_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DOTSEDRAFT_66315</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WK03"/>
    <dbReference type="STRING" id="675120.M2WK03"/>
    <dbReference type="eggNOG" id="KOG3049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_0_0_1"/>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="20">
        <location>
            <begin position="78"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="21">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EME39283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="296" mass="33535" checksum="328CD59AA1CBA691" modified="2013-05-01" version="1">MALRLATRRFAPQVFRRGMATTIEHTKEPISAVAEATSASQPPIPANKTGTQHEPKPDENSRIKTFQIYRWNPDEPASKPKMQSYTLDLNKTGPMMLDALIRIKNEVDPTLTFRRSCREGICGSCAMNIDGVNTLACLCRIPTDPKVESRIYPLPHTYVVKDLVPDLTQFYKQYKSIKPYLQRDTAPADGKENLQSKEDRRKLDGLYECILCACCSTSCPSYWWNSEEYLGPAVLLQSYRWIADSRDEKTLQRKDALNNSMSLYRCHTILNCSRTCPKGLNPALAIAEIKKSMAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2WL81</accession>
    <name>M2WL81_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_66657</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WL81"/>
    <dbReference type="STRING" id="675120.M2WL81"/>
    <dbReference type="eggNOG" id="KOG3989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081915_0_0_1"/>
    <dbReference type="OMA" id="TIAFGYW"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME39728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27754" checksum="C41E392F9AF6FC4A" modified="2013-05-01" version="1">MADRAANKLLSHHPLQRLPSPSRGASALLHSLGLASFAYSFSYLVRNPNPVNDSYGWHMQYLTIIGLSLATATFAVGLLADLTLSHRLFQVKNVLSVASAPMECLISVLYWGLRAIDPKLVLPDWAPPLAFTADLSFHAVPSISLVVDLLFFSPPYTIAFLPAFGLSGCIAFGYWFWIERCYQFNNFYPYPIFEILTTTQRVGLFGFSALLMTTATASLVWLYGYINGKELENTGTRDLRRTKSGNVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2XJC5</accession>
    <name>M2XJC5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PEBP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_56905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XJC5"/>
    <dbReference type="STRING" id="675120.M2XJC5"/>
    <dbReference type="eggNOG" id="ENOG502SPPN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107650_0_0_1"/>
    <dbReference type="OMA" id="PRDSTNH"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004028729" description="PEBP-like protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="25972" checksum="9440ABFC8BA3E84E" modified="2013-05-01" version="1">MQYQKQVAAVFSLLVAQGTCQTPAGTAPITDKHLNIAYGDTVVEASDLLPQALVQSAPNAWLSRTVSGDHMLLLVDQSIPQSSINSTGPQAPGLEYCRTTRLHWFQTDLNQLDNGCLVSETAPIAMYGGPMPGINDIAHTYVFYLFAQPSNFSLDAATWDAGGKYDPISVYDRMNFSTFAISAIPGVGHPIAANYMRVQNPDTTAYGTAPNGTCPLDSGLSSLTVNTTHTDTPYYHRSWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2XZX0</accession>
    <name>M2XZX0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_83383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XZX0"/>
    <dbReference type="STRING" id="675120.M2XZX0"/>
    <dbReference type="HOGENOM" id="CLU_403334_0_0_1"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="500"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME38634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="682" mass="74763" checksum="981CB58704B61177" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y3U8</accession>
    <name>M2Y3U8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 92 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_88969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y3U8"/>
    <dbReference type="STRING" id="675120.M2Y3U8"/>
    <dbReference type="eggNOG" id="ENOG502QR5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_4_1_1"/>
    <dbReference type="OMA" id="YQDPIAC"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF23">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004029226" evidence="2">
        <location>
            <begin position="29"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="4">
        <location>
            <begin position="39"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="3">
        <location>
            <begin position="289"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME42969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="804" mass="88126" checksum="A808750846CDBAA9" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y4G2</accession>
    <name>M2Y4G2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y4G2"/>
    <dbReference type="STRING" id="675120.M2Y4G2"/>
    <dbReference type="eggNOG" id="ENOG502S3MD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012320_0_0_1"/>
    <dbReference type="OMA" id="QTWRSWY"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="869" mass="94820" checksum="605E6D164182BC7A" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y5L7</accession>
    <name>M2Y5L7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_45432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y5L7"/>
    <dbReference type="STRING" id="675120.M2Y5L7"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044999_0_0_1"/>
    <dbReference type="OMA" id="APHIYLI"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF2">
        <property type="entry name" value="KETOREDUCTASE (KR) DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME43539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="365" mass="40143" checksum="1EB03FBB1077CE40" modified="2013-05-01" version="1">MVKIDAVRESNLKVKEISDLVTVFLGGTGGIGESTAKELFLRSTRPRAYIIGRSVDRGNRLINELQEIQPAGTAYFIQKDVSTIRAVDELCAELREREPKIHCLVLTAGFMTLKGRSETAEGIDSKMAVNYYTRMRCILNLMPALTRASEANELSRVITVLAAGSEGDVREDDLGLKHNFTLHACLAHCVVMSDFFLEELAKRCPQTSFSHSYPGTVKTGIANQLSGPVRLAVKLMYAVMTPWILNVQESGERHLFQMTSQCYPSRNAGVGIPIPEGLSVMIGSDGTRGSGAYLLDWDGKSTGDTDMLEKHRGKDMGTKTWNHTMAMFQQAEARSRKDSKRPSNGEDGGAGRSIPDPPGWRPGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2YI19</accession>
    <name>M2YI19_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_29734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YI19"/>
    <dbReference type="HOGENOM" id="CLU_1229901_0_0_1"/>
    <dbReference type="OMA" id="DSANYEP"/>
    <dbReference type="OrthoDB" id="10404672at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="225" mass="25158" checksum="D436436BC8A9C6AB" modified="2013-05-01" version="1">MSTDIQFDSQVKRLNAAVARFANVEVEWLKKDMTARRDIRQPCAADAFLLTGALEHTPSSSNFDGSDDPNVVLTTIEGYKQQIELVPVIPSTYKVFGEAVNAVEALGNSSKIISLEKVTKLIDAAHVLVDDLEDRMKQRDTSVGKKSLPRLTDVQLLVAWNQVCELYQRGAKLDESIAEIKHQLKAELTGVKKLATEPVVITKLWFKYDSANYEPRILKPDSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2YI79</accession>
    <name>M2YI79_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_75417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YI79"/>
    <dbReference type="HOGENOM" id="CLU_640967_0_0_1"/>
    <dbReference type="OrthoDB" id="10666946at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME38650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47465" checksum="58468E2D03EE62F7" modified="2013-05-01" version="1">MGEGGGANVPLGSKSKTLATQFQMLEDLFGAMMVKNEKLEADVKNATLQAKEATRKMEATQLENEVLRKDVTQHGKKLKQIEGKGSKPASQKPDQSCWDKQIEGLQVPLQAAANMAIATTHETAKLKKYIKSVDDKRADDRSDLEHKNMLADIKMVNLEATVPVSSGDVMSSAYLYALESRLTQLSERITPPRSPFHKPIGQVLVANFSETSPYSPEWLLKWNFESDIGPVSQVVMFHQYNSLNALALVQFEDADHATRAHTHDCRSFIWTPTKIEVKEVLYLDGGTIPSSRQHRVVVTGLPIHYSLEDVQTLLRSTLRPFAGDDDQDSDDTAMLSRDAQGQFTGHAIVQPEDAEDIGRLVRLLDEKVLDGSELRVGIVEDEGWVEGFDVEIQGLERLRSLGGSEQDGAQWKYEEGHCADDWSTASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIE1</accession>
    <name>M2YIE1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribosomal protein S9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">S4</name>
        <name evidence="11" type="synonym">rpS9</name>
        <name evidence="11" type="ORF">DOTSEDRAFT_92035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIE1"/>
    <dbReference type="STRING" id="675120.M2YIE1"/>
    <dbReference type="eggNOG" id="KOG3301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089738_0_1_1"/>
    <dbReference type="OMA" id="RQFITHG"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME38681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="193" mass="22306" checksum="E27215FD698A0711" modified="2013-05-01" version="1">MAPRSYSKTYKVPRRPFESARLDSELKIVGEYGLRNKREVWRVQLTLSKIRRAARQLLTLDEKDPKRLFEGNALIRRLVRVGVLDESRMKLDYVLALKVEDFLERRLQTCVYKLGLAKSIHHARVLIKQRHIRVGKQIVNVPSFVVRLDSQKHIDFSLTSPFGGGRPGRVRRKKAKAAESKDDGEDGGEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJ03</accession>
    <name>M2YJ03_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_29108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJ03"/>
    <dbReference type="HOGENOM" id="CLU_1034476_0_0_1"/>
    <dbReference type="OMA" id="DVEESTW"/>
    <dbReference type="OrthoDB" id="10580846at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="269" mass="30832" checksum="26CD024D0A809F61" modified="2013-05-01" version="1">MSVDPSVLRGESLVVDCVGALEGLLEIVDSADTSPDTALDSDVEESTWSSNFTPVQHRRRIYLDTRQQLDTEQIMHLQGFYRQECEVKNNLQDAVISSLFDKDIPQPKRKLEGGAWAQQVQQGPSLNTADFGLIGQGQLQRITCEADRIARAQGWIETARNLPGFGLPVYKEHVLEMFFLIKPEANGAEIFSLTFGLQLPRQAVEQFFERKLELTKEWRQMIKRLGMKRFLRRVERKGLLEEMQQVELARARSIQDMKRDEAGRELPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJ32</accession>
    <name>M2YJ32_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-malate dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="4">1.1.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_180975</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:18365"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.83" evidence="4"/>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJ32"/>
    <dbReference type="STRING" id="675120.M2YJ32"/>
    <dbReference type="eggNOG" id="KOG0786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="OMA" id="SIFTRHC"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046553">
        <property type="term" value="F:D-malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050501">
        <property type="entry name" value="ICDH/IPMDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275:SF1">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="11">
        <location>
            <begin position="14"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME38950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="373" mass="40704" checksum="74850A28ACBA1C3C" modified="2013-05-01" version="1">MSPIAISSDTKTYSIACIPADGIGPEVIAAGVEVLETLSDASGSFTLDFENYDWSSETYKKTGKYIPDGGLDSLRKHDAILFGAVGAPDVPDHISLWGLRLAICQPFQQYANVRPTKIFKGTESPLRRAKTGDLDWIIVRENSEGEYAGQGGRSHRGLPWETSTEVSIFTRHCVERLIRFAFETAQKRPRKHLTVVTKSNAQRNGMVMWDEVAAEVAKDFQDVTVEKMLVDAMTCRMVLQPQSLDTIVATNLHADILSDLAAALAGSIGIAPTSNLDPTRQNPSMFEPIHGSAFDITGKGVANPVATFWTAVEMLKWLGEEKEAERLLECVERVCGRGILTRDLGGNAGTKEVTEAVKKEIRAVYGKGTKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJ50</accession>
    <name>M2YJ50_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_180949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJ50"/>
    <dbReference type="STRING" id="675120.M2YJ50"/>
    <dbReference type="eggNOG" id="ENOG502S6BE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_606938_0_0_1"/>
    <dbReference type="OMA" id="SEAHIWR"/>
    <dbReference type="OrthoDB" id="4156714at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="451" mass="50873" checksum="070F311CABB2FC9F" modified="2013-05-01" version="1">MFREIKKHKAEKAELRETIEACKQSIYDLQVELAESTAEVRQARLHEQKKFDATKAALVESSKRQVAQRVEDANKHYARCIKDARNEVAHHAADANRKADQKLVVTRKECERLQLSNQDLHERCAGYEVQLDRLRAQVKVMQEASLRNVEAEHWAPLAVSDIDRKLKAILSDVKQWSVKYATMSLQDMIASPRFHHIGFRLQDESCTSSTQNLLEKLARNTSMIKKPGKAAALLLAALVSSVVMRRIIHDPFFAFVGRGASTLILKSDAEGLEHVFAQLLEQDEVGAHAWRCQLFRLLDPPGAAKSDTAEHAKNIAEKSRREAASQWAEIIMGEAVDVLVPTVDHKAALPGLQSILLRAAELSWAFLARKQSVKVRDIEYLDKDRALRYDHKADDLDTHVFHCPEVEDEPDALDGRKIVLLCNPAVVAYGTADGTDYDKSKIWHKAMVWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKQ4</accession>
    <name>M2YKQ4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_28599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKQ4"/>
    <dbReference type="eggNOG" id="ENOG502SIDK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1156362_0_0_1"/>
    <dbReference type="OMA" id="TAYNIME"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004030297" description="DUF7703 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME39450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="240" mass="27153" checksum="072A8AC6E05B3C15" modified="2013-05-01" version="1">MIIINFLILHLPTTVLTFGANGSEHTETFETAYNIMEKIQMAGFFIQELILSSIYIVETVQILRNSLRHGTRRIMKQLIFMNIVIIVLDLGLVGLESASLYILQVLLKSVVYSVKLKLEFAILGKLVQFVRGTKSGYVDHGAGAGFITTSTHMTREEKQMRTSEFVDLSRVGVNVSHPLFTHRHCNLLSPRRGSTRASDGLNMTLEYKIARFEHIDHILKLPLDEDSPRDSLALMHDNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLU1</accession>
    <name>M2YLU1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_24972</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLU1"/>
    <dbReference type="STRING" id="675120.M2YLU1"/>
    <dbReference type="eggNOG" id="KOG3372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068714_0_0_1"/>
    <dbReference type="OMA" id="WVGALTW"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME42976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="249" mass="27509" checksum="9C444D9F27AFB92B" modified="2013-05-01" version="1">MHSSLVRVQNVFGFFTSVAFAVAAAIALSVLLSPQAPSASLELKNVKVAKGRPHYYSPKREEYAHVTFDLNTDLTSLFNWNTKQVFLWVEASYPSTSPSTIPSSEAVIWDAIIPSSYAPFHQNTYIHPIAKKLTAKEKKALKNKKGLPYPAGASPGIVRLEGQKPKYQITDVTGKMAGRENATLTLHWNVQPWVGMLTWTNRKTYGRWDGLKGGKSDTFAFPPLKGSETVKKEDLKTETGGERNRGSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLX9</accession>
    <name>M2YLX9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_72363</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLX9"/>
    <dbReference type="STRING" id="675120.M2YLX9"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="OMA" id="FGCAVEL"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000009">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="149"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME42895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="332" mass="34892" checksum="2A682E4CF081905E" modified="2013-05-01" version="1">MVRAVVAGASGGIGQPLSLLLKASPLVDQLALYDVVNTPGVTADLSHISSVAQIEGYLPENGEGIKKAFKGADIVVIPAGIPRKPGMTRDDLFKINAGIVQGLIQGVADNCPDAFVLVISNPVNSTVPIAAEVLKKAGVFNPKKLFGVTTLDVVRAETFVQAITGTKDPAKTKIPVIGGHSGETIVPLFSKAEPSVNIPADKLDALTNRVQFGGDEVVKAKDGAGSATLSMAYAGFRFAEQVIKAAKGESGIVEPTFVYLPGVEGGDEIVKETGLEYFSVPVELGKDGAHKARNVVKEANEYEKKLLQKCYEGLKGNIEKGIEFVHNPPPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2YMS4</accession>
    <name>M2YMS4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_35574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YMS4"/>
    <dbReference type="STRING" id="675120.M2YMS4"/>
    <dbReference type="HOGENOM" id="CLU_449786_0_0_1"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="67741" checksum="6AC95E6484F95D04" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>M2YNC7</accession>
    <name>M2YNC7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_102108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YNC7"/>
    <dbReference type="STRING" id="675120.M2YNC7"/>
    <dbReference type="eggNOG" id="KOG2496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022620_4_1_1"/>
    <dbReference type="OMA" id="FRVEQNT"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="74"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="340" mass="38693" checksum="3E2E9FD81AD429F8" modified="2013-05-01" version="1" fragment="single">LSEDDIYRTSTQYRLWSFSPEQLSTRRRKTHELALARARQLHASQTGDQQHNGSAQPEYLTEREELRLIHRYCELIQTTADHLKWPSNIKPVAVQYLKRFYLSNSCMTYPPKEIYKTILFLASKTEAYHLTVTKFAQSISADPEAILAPEYKIMQALRFTLDVRQPFRGLKGVLMELLNMAEGLKHFIDRIQACYATAKNLCDGPASLTDAYFLYTPSQILLAALHIADTPLTAFYLDTKLPLTLVSRPKILATIEGCAALLSSYDQKDSMGKEERAALEKKLDLCRDPTTKDLVKAHAEMKRNGAEDGVVDEHEAKRRKLEREKRAKEDPFGPSLGNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBF2</accession>
    <name>N1PBF2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_29275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBF2"/>
    <dbReference type="HOGENOM" id="CLU_1378084_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="198" mass="21322" checksum="303ED82691A9F2F7" modified="2013-06-26" version="1">MSKQQMREKWKRVEEYGGVELVEKARKRLPASAPRNIEKSTDPPEPEKVPKPTPVASKQPAAPRRTPNTRHPQSPSHVHNDRPSHPYDLLLPCQPTSTMVVVPRAPSGLSVLAPPQNAAKGRLHSTATRHEADHANDRPCTTAASAPPSRQPAAPCILARYACRAVSNSGMGCAPSNGQPTLVANRRLTTALKAPASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBG6</accession>
    <name>N1PBG6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_140974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PBG6"/>
    <dbReference type="eggNOG" id="KOG2079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000917_0_0_1"/>
    <dbReference type="OMA" id="NQLFFHQ"/>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23413">
        <property type="entry name" value="zf_RING_Vps8_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="2">
        <location>
            <begin position="672"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="3">
        <location>
            <begin position="1214"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1455"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1455"/>
            <end position="1468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME38272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1533" mass="170256" checksum="1DD86C05CD73A020" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCJ2</accession>
    <name>N1PCJ2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">clp1</name>
        <name evidence="8" type="ORF">DOTSEDRAFT_158948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCJ2"/>
    <dbReference type="STRING" id="675120.N1PCJ2"/>
    <dbReference type="eggNOG" id="KOG0840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_3_1"/>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009205">
        <property type="entry name" value="PRK12553.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME40223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="200" mass="22117" checksum="B0B293B3673FCDD0" modified="2013-06-26" version="1">MPFVTETVGGGWHTSDIFSRLLKERIICLNGEVEETTSASIVAQLLFLEAENPSKPISLYINSPGGSVTAGLAIYDTMQYIQSPITTICLGQAASMGSLLLCGGEKGQRYCLPHSRIMVHQVSGGYSGQASDIAIHAKEILRVREQLNKIYQRHLTVERSLEEIGRVMERDFFMGAEEAKEWGIVDTVLDRRAQAEEGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD04</accession>
    <name>N1PD04_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lethal giant larvae (Lgl)-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_74735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD04"/>
    <dbReference type="STRING" id="675120.N1PD04"/>
    <dbReference type="eggNOG" id="KOG1983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006030_0_0_1"/>
    <dbReference type="OMA" id="QIYVFGQ"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000848">
        <property type="entry name" value="SNARE-dependent exocytosis protein (Sro7), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="5">
        <location>
            <begin position="521"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="909"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME39964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1007" mass="109528" checksum="F91C8C1E1031AF46" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE29</accession>
    <name>N1PE29_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE29"/>
    <dbReference type="STRING" id="675120.N1PE29"/>
    <dbReference type="eggNOG" id="ENOG502QRJE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017366_2_0_1"/>
    <dbReference type="OMA" id="WPMGTVE"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108722" evidence="2">
        <location>
            <begin position="17"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="576" mass="64793" checksum="906D78354C0CDB6C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE64</accession>
    <name>N1PE64_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE64"/>
    <dbReference type="STRING" id="675120.N1PE64"/>
    <dbReference type="eggNOG" id="ENOG502SCKR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_611145_0_0_1"/>
    <dbReference type="OMA" id="TPFDMLD"/>
    <dbReference type="OrthoDB" id="5374569at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="448" mass="49586" checksum="29E8E0CD58224430" modified="2013-06-26" version="1">MPRTLPWLAGAAAKKESSRKAKSGQPNRKRFSSPGDLVNSDLESIGDSPKRRPKKRINRGPSSSPPPVKVAPLVEYMRDGFAMDDRYMMVEDEFTSTANLFSLPLHQDEYERTKRRARARGAETLKLIGHGTDGTTGQSRALRLSLEVDERARRRKEAAGGDHSGDEEEEEFMADSHLAGLMTASQGTPRKSLRGYASNSQRTPRVGGGRTRDVVGEGTAYRKPAISAIEENAGTEDEDELDAYVARARPIARKRPNAIERPTANTSARHAEEALQRTLVKEKPTSKTGIFKQFTNAALAERERRDGEKVKSDSLARSSTPREIVPSVRKSSPTRSALRDTSNTNDQSNHIKMSRTAAILARRREAQLHTNQADASPEKQAKQELQSQVGPKEELVSHNRIHIMREPSSSTIRQASASKSLARRGAERATQDAEEKSVSQFDDIPTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PED7</accession>
    <name>N1PED7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_74736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PED7"/>
    <dbReference type="STRING" id="675120.N1PED7"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024893_0_1_1"/>
    <dbReference type="OMA" id="MTSIGCF"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108730" description="WSC domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="48"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="317" mass="32281" checksum="3845EB6FD7141C2F" modified="2013-06-26" version="1">MPSTTRATTARMAHILTLLSLLTASATAHVWAEDPHAIHMNRLIKRTPAGGLGCFSSSGNLDSLGSYLYQASGYCLQQCAGKAITALTGGDTCLCGDEAPPLSDKVDSSKCSINCNGYPQEKCGGDGFYTVYATDGDASGAQYEGGDSTSSSSSSSSSSSSSEGSTTQAPVTTGKATVVSSTVAGGSTVVVTQFATSDPKTTSSASGGGGGGGGNTAGIAAGVVVGVVALAGLIAGLVFFIRRKKQKEAEEEFRHKNQVSDFMRGASERKPPGTGYSGLSDQRLDPEAGARRNSVGSLADNQDYSRRILRVANPDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEH6</accession>
    <name>N1PEH6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEH6"/>
    <dbReference type="HOGENOM" id="CLU_2015206_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109045" evidence="1">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="123" mass="13211" checksum="1D87D60CF8C1D1F0" modified="2013-06-26" version="1">MVARSALAKMTPLLAIVAALGDHWLDFLVEVLRGQRMRTSEEAQAHPGKSPSSSNDRAALLRSVLNLSRPLLKHCIYIPSRGYGAASSILPSTLPQSSDPSCATINSGYRVCPDCACRDCRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF22</accession>
    <name>N1PF22_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7907 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF22"/>
    <dbReference type="STRING" id="675120.N1PF22"/>
    <dbReference type="eggNOG" id="ENOG502SSN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133908_0_0_1"/>
    <dbReference type="OMA" id="WEPIVIN"/>
    <dbReference type="OrthoDB" id="3518533at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057229">
        <property type="entry name" value="DUF7907"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25484">
        <property type="entry name" value="DUF7907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109337" description="DUF7907 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7907" evidence="2">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="194" mass="21542" checksum="58A29F5584832939" modified="2013-06-26" version="1">MKYLALFLALVAFVSAYNNTTAEYKLQTRLKVADVSKQEYDGLYLSSYHTGAGLNDVVFSDEPPLGNATLAATNITANGTTYYNQLFDLGNDFPWGLVMESNIEFYSAWQPVELNAGASGSNYDVSGFFINETGLQWTSNPGQVGTDDDEFGGWLVCDWWHGVPQLFFRISYYSSSVYQAPASCADVYLIPQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFI9</accession>
    <name>N1PFI9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_73538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFI9"/>
    <dbReference type="STRING" id="675120.N1PFI9"/>
    <dbReference type="eggNOG" id="KOG3677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029210_2_0_1"/>
    <dbReference type="OMA" id="AGWFIRN"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="268"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME41132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="486" mass="55713" checksum="08CB1CC009C4D235" modified="2013-06-26" version="1">MSVRKAPTYQQGAPERVPDDDSDVEEEALANNYREQVGYQDGLGEDYDLERSSTIGGTQDLQAQLQAAATPLEYGASLEVKIQSYDSYCNLFHFILNSDGPVDIDVPSYYWAWDVIDEFIYQFNSFCAYRQRAAFQQDSSSANVPEEDMTVLRENPQVWGCYSVLNVLYSLIQRSQISEQLEARKRGEDGALYAGEYGNRPLYQMLGYFSIIGLLRVHCLLGDFSLALKTLDNIELNKKAMFARVMAANFTTYYYIGFSYMMMHRYADALRAFNHILIYVSRTKNFQKGAQYDSISKKNDQMYALVAICVAFHPTRLDDTIHTALREKYGEQLTRMQRGGPEALPIFEELFRAACPKFISPTPPDFENPHLNPDPIEHHLTIFMNEVKNNIFTPTVRSYLKLYTTMDITKLAGFLEVDADTLRSWLLVNKQRSRQVRHSEGGLLEGDVVNTSDLDYSMEGDLIHVSEAKVGRRLVDWYLRNLARTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFY8</accession>
    <name>N1PFY8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_73629</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFY8"/>
    <dbReference type="STRING" id="675120.N1PFY8"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016776_0_0_1"/>
    <dbReference type="OMA" id="NTHMLRC"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="12">
        <location>
            <begin position="213"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="11">
        <location>
            <begin position="582"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="738"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="802"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME41277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="835" mass="91979" checksum="66870F2D8CC84167" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG92</accession>
    <name>N1PG92_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG92"/>
    <dbReference type="HOGENOM" id="CLU_3050298_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109818" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="54" mass="6061" checksum="62CD412997B709C1" modified="2013-06-26" version="1">MLLLILALPACILSVCIELAHSWQIEIKLGRKSTAGKWKSIATTRQSSRTERTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH27</accession>
    <name>N1PH27_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_157061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH27"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_3_2_1"/>
    <dbReference type="OMA" id="WNIPELY"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF15">
        <property type="entry name" value="NICOTINAMIDE RIBOSIDE TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME41928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="522" mass="56676" checksum="494D1F5A843F7C80" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIA0</accession>
    <name>N1PIA0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_81099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIA0"/>
    <dbReference type="HOGENOM" id="CLU_1578500_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="169" mass="18837" checksum="9C3E05B13EEDC102" modified="2013-06-26" version="1">MYEDFREESLLCETGAATQPYYLGVKENTVLEFLPKCTKSDRQALQHCSHRAGFSFEDAHGSNRLVRSVVTALYEPPKACRQAYLLGPYTQLGSLILDWEKRLAGNELRNSHGGIRLTACNRPQEVSRLWKICVVGAQILPKPQIGKVDGNTIEVSTEQNGSDLTLVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIR0</accession>
    <name>N1PIR0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_73369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIR0"/>
    <dbReference type="STRING" id="675120.N1PIR0"/>
    <dbReference type="eggNOG" id="ENOG502SRTS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538810_0_0_1"/>
    <dbReference type="OMA" id="NAYYTVG"/>
    <dbReference type="OrthoDB" id="2565331at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="572" mass="54711" checksum="34FFEF713E964675" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJC1</accession>
    <name>N1PJC1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_36495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJC1"/>
    <dbReference type="HOGENOM" id="CLU_1454378_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109828" evidence="2">
        <location>
            <begin position="28"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="186" mass="20771" checksum="7B0005E699555859" modified="2013-06-26" version="1">MWSDCSFTVPFFLAILILGFFKDPSNFQEHIIGSTFSLRPPSSTTSRHDNPGLPTQVIEALQPILFDRRDQPFLAWSTWNFQSLSSPLPDPTSISIPPGITVLHKRIPMHQHLSGPILRSCPIGHDILTIDRDPDLERFGEPSPHKENDWQMKLSRIDGVDLGGRAGEGGWKTRNVGLGNEYDSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJL4</accession>
    <name>N1PJL4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_73213</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJL4"/>
    <dbReference type="STRING" id="675120.N1PJL4"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495234_0_0_1"/>
    <dbReference type="OMA" id="EMTMHEL"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME42309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="550" mass="59343" checksum="8D52A8B0F181B8B5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKC9</accession>
    <name>N1PKC9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_71586</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKC9"/>
    <dbReference type="STRING" id="675120.N1PKC9"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007561_1_0_1"/>
    <dbReference type="OMA" id="FKLWEAQ"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="47"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="670"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="724"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="894"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="682"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="739"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="894"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="940"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME43796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="952" mass="104984" checksum="2F4A0C289ADA0318" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL19</accession>
    <name>N1PL19_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL19"/>
    <dbReference type="HOGENOM" id="CLU_1959534_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="13300" checksum="59DDF75D0C5C63BB" modified="2013-06-26" version="1">MAAVGSTTMTTSTTVTIDSSLLASAPTRIAEMANAPGGRSACISGMYWSAPDNELHIILSLAVCGTLENVGPELGRRQMSARTELSSGPGCSPETSLGKLPCQASQPHHAVLVDMPKLSYMDQSALHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL61</accession>
    <name>N1PL61_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL61"/>
    <dbReference type="STRING" id="675120.N1PL61"/>
    <dbReference type="eggNOG" id="ENOG502T481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_563846_0_0_1"/>
    <dbReference type="OMA" id="WNTEMEL"/>
    <dbReference type="OrthoDB" id="3650959at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="484" mass="54633" checksum="743D23C1E82F2757" modified="2013-06-26" version="1">MCVIDQKTYLLGSGREEIVEKRHYCHNAVGRILCQHIQRRDLGVVRTVERRPSVNRATASEPLITTSKEGRERRLYPLSSLNRRFSKSASSGQASATSTASPVDSAASLSATIPPVYKEVRPEAPMPPSTYKTYPSARQMTPTVSNAPPDTRRTVRPDGTASYERPPSLEMPRAAFNERTPVPRQSPWSSTNADIDEPEALPSRPSCRRVSFRDQRPDTSIDFNAATHGYASAGRPSSPGLGQLPRISKDGNSKGKGHVRVDSVRDEEDQARREQACLSGADRRQRARQSRDAEEAARERAESLHCEKEEASYERKERKRREAQDALEGREERPRSETMQRRIDAEIAQIAREQQEAERRRCEEAARCSTSSVRSYTYPPSSPTPSNSVPLSARRPAPVAVHNHRPASRDSIAEHGAAVIERYARAADNQQLNDALVYMEMEDMRAAQGQFDADPKASRRTSERTPRRRERRQRENERDVEYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLA5</accession>
    <name>N1PLA5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_73227</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLA5"/>
    <dbReference type="STRING" id="675120.N1PLA5"/>
    <dbReference type="eggNOG" id="KOG0935">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_3_2_1"/>
    <dbReference type="OMA" id="QSNFVEY"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME42330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="145" mass="16979" checksum="1F9CE8B34A156AEC" modified="2013-06-26" version="1">MVLSFILIQNRQGKTRLAKWYSGYNDDEKIKLKGEVHRLVAPRDQKHQSNFVEFRGSSKIVYRRYAGLFFCACVDANDNELAYLEAIHFFVEVLDQFFGNVCELDLVFNFYKVYAILDEVFLAGEIQETSKQVVLTRLEHLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLC0</accession>
    <name>N1PLC0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_88173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLC0"/>
    <dbReference type="eggNOG" id="KOG3798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020884_2_0_1"/>
    <dbReference type="OMA" id="LPCQYES"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000048">
        <property type="entry name" value="Zn-dependent hydrolase/oxidoreductase family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="130"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="414" mass="45653" checksum="E070AF2091D2DADC" modified="2013-06-26" version="1">MVSLVTGVWLNSSGEPPVDQWVHAIESWAGTAPLSTGPTEQGERRWSHHNKGSGFNNPWPSFVDPGGPTIGRKILLRKIKGTENVPDTKAETVPVRKPVFLQERQPENESLRVTWLGHACVFAEFPTGLRVLFDPVFTPRCSPFSFMGPKRYTEQPCQVDDIPIVDVVVISHNHFDHLSEPTVKEIAKRHPNAQFFVPLGLASWFKSTGIPNVTELDWWESRDYVLGSKATSQTNGASSGNGAGTQTINATFGCLPSQHQTARSGFDRMSTLWASWSVSSGGKSLWFGGDTGYRTVPEASEGKDDYSGEFAHLPVCPAFSQIGQLRGPFDVGLVPIGAYAPRFIFSPIHANPEDAVNIMRDVNAKKALGIHWGTWILTEEDVLEPPRLVKAALKKKDMPLDRFEVCDIGESVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLI9</accession>
    <name>N1PLI9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_25806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLI9"/>
    <dbReference type="HOGENOM" id="CLU_1722330_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="152" mass="17944" checksum="35AA5D740BB3068C" modified="2013-06-26" version="1">MEKDYFLLDEKVYISMRQFWRASYITRCVRARNKRGQDIYHSYLTKRMHAPREESRITIVAAKAVLQRFIPPGALTHVFYKSRLLHVQMKREAGVDARAMRFGGDAFQMLPAVAKTPQQARRLLCKVEEFRRSPFWNGHCWEEFLSQGAAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLM3</accession>
    <name>N1PLM3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_171858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLM3"/>
    <dbReference type="STRING" id="675120.N1PLM3"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OMA" id="ECTAPCA"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="458"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="564" mass="63477" checksum="723425B91F47A019" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PML2</accession>
    <name>N1PML2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_35025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PML2"/>
    <dbReference type="HOGENOM" id="CLU_1896165_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="134" mass="14546" checksum="175055C82CE35F78" modified="2013-06-26" version="1">MKSRHYDLVLHRALILCREPEPIGTKQTQAGWHKCCGRSIQAAYRKAASAQLKVWPSVVADRSGCTSSGTPPADVSIDLILAGILEPVAIGLAPIQIIELGQLMPKYPADITMDTNKLAQGSRAHRQVVMQMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMN9</accession>
    <name>N1PMN9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_104370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMN9"/>
    <dbReference type="STRING" id="675120.N1PMN9"/>
    <dbReference type="eggNOG" id="ENOG502S73V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080664_2_1_1"/>
    <dbReference type="OMA" id="MTITHIV"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="108" mass="12658" checksum="2A53A93246E592D0" modified="2013-06-26" version="1" fragment="single">MTDTITHIVLFKYKPDITWTQFEDHFSAFTALKTRCLRDGKPYMKSMRMGKNRSWEPFSMGLTHGFVLEFASQEDLDYYLTKDEIHAEFSRNAKPLIEDSVVVDIRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMS4</accession>
    <name>N1PMS4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_72255</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMS4"/>
    <dbReference type="STRING" id="675120.N1PMS4"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009020_4_1_1"/>
    <dbReference type="OMA" id="FLFFGSQ"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="151"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME44736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="554" mass="60054" checksum="5661C52FBC46EE4F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN21</accession>
    <name>N1PN21_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_71974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PN21"/>
    <dbReference type="eggNOG" id="KOG4204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001360_2_4_1"/>
    <dbReference type="OMA" id="MCEEVIK"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="766"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="440"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="581"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1051"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1541"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1110"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1121"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1546"/>
            <end position="1564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME44313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1564" mass="174486" checksum="E08FE4B917FAA2CA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNH4</accession>
    <name>N1PNH4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_24051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNH4"/>
    <dbReference type="STRING" id="675120.N1PNH4"/>
    <dbReference type="HOGENOM" id="CLU_1250655_0_0_1"/>
    <dbReference type="OrthoDB" id="3648779at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25444" checksum="ED4A58E4A6034075" modified="2013-06-26" version="1">MATSAAQEDGTIKELLAQNTAYKKIARKVGRNFDQTLKDRINDLREQDRQSKSQASLKKKFQEQNQPDPPTQQHNLNHIQAPKQKDDDDEYVALHEGTHKGEHVVLKAFCILGDRAVSHRAQNEKNALKQLTKRGYQHAPQFIVAFTKPFDGLVCRSESYVVMTKVPGMPLWRLRRDDEKLGDTREVEDAFAIAIADVHRREVDNGSHYDDNIMWDPEQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNJ8</accession>
    <name>N1PNJ8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_170074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNJ8"/>
    <dbReference type="STRING" id="675120.N1PNJ8"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_2_1"/>
    <dbReference type="OMA" id="WSHIHID"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="365" mass="39666" checksum="897854074D6E2CDE" modified="2013-06-26" version="1">MSRLLNPKLFITGATGYIGGDALYAIATAHPDWDFTCLVRNSDKGAKVAQQYPKIKFVYGTLDDAELIEGEVKKADIVCNFANADHEVAATAIARGLAAHDPSAPGFLIHTSGTGILLFEDIRDKTFGTQFRDTVYDDLEGVSKVTSLPDDAPHRNVDKIILKVGTDHADRAKTAIVCPPTIYGPGRGPDNQRSHQLPELCRVTIERGHAIKVNEGKTYWTNIHVHDLSDLYLKLAEEAAAGGSTKEWPDKPATWGAEGYYFTENGEHVWGEVSQWIATEAKKQDLTSTDEVKSVSPDDAAKATPFGQALWGANSRCRAKRGKVILGWKPTGGSFKDEVKRALEWEAKALGTKPGHAKVAAEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNM9</accession>
    <name>N1PNM9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNM9"/>
    <dbReference type="STRING" id="675120.N1PNM9"/>
    <dbReference type="HOGENOM" id="CLU_776185_0_0_1"/>
    <dbReference type="OMA" id="WHEENTL"/>
    <dbReference type="OrthoDB" id="3892448at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="357" mass="41055" checksum="BDCED26F7A330DD3" modified="2013-06-26" version="1">MHLRSLNTLEEVASSRPAIRNAIKSLFFQTDGTNFWLEHHANRDRRRFDIWHALRQRAHETEGPRYISLLANHNTKDDAGRNAVVYAALLNCHSTNERANHDYPRPDADEPSDDAWQSAPRDDEARKDPQLISAFEHYKKLTKDEIRMSSESLVQAKLMGLFRSCPNLTKLSFNVKDILRRNNAFESPEWLRGLFVPHGATFQQPAAFMQTMSAAYDASVKLLDLSVGYGPELLDSFGDDERLHLALKDLTRLHWRVESADPWGNGNTGDFRDFSTSLCRGYLRQITSSCQKMQCLYLDMMHHPLDTHRAWLKAIISSDLVFQHLRHLRITNFQASPDQLSSLLLRHAKTLESLHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNX1</accession>
    <name>N1PNX1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_23185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNX1"/>
    <dbReference type="HOGENOM" id="CLU_2236519_0_0_1"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="105" mass="12478" checksum="A033224A1114A06E" modified="2013-06-26" version="1">MPKKKLQRSENLLERYARISKIVDHYTYMIRDQINSVSLELLYFVALYALPVGILYHGVLRWNLESEFWIHVWLSIIALPYLAFIAYVWAESGFSMDAMVTRWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPQ2</accession>
    <name>N1PPQ2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_71180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPQ2"/>
    <dbReference type="STRING" id="675120.N1PPQ2"/>
    <dbReference type="eggNOG" id="KOG1262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025883_0_0_1"/>
    <dbReference type="OMA" id="HWFADTI"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME45362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="534" mass="60030" checksum="A2C78AAB6D7ED0F3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQK6</accession>
    <name>N1PQK6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_152588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQK6"/>
    <dbReference type="STRING" id="675120.N1PQK6"/>
    <dbReference type="eggNOG" id="KOG1243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010392_1_2_1"/>
    <dbReference type="OMA" id="NDTSWAG"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="782" mass="84186" checksum="5EE7A52432C96440" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQX4</accession>
    <name>N1PQX4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_170687</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQX4"/>
    <dbReference type="eggNOG" id="ENOG502S6CG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029871_5_0_1"/>
    <dbReference type="OMA" id="GINTMAN"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF15">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109271" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="84"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME45343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="420" mass="44795" checksum="3921C8A53B1BF884" modified="2013-06-26" version="1">MALLIVLLAVAAAAYPWVESAAGLDSSLLKRGYAVQERDSAQCPFNANHVSAPLVTAQYPYNNAKNGQPGDGKGGYPVPAPGDTVHEFRAPDAQTDIRGPCPGINTMANHGFLARDGITTYNELVDAQQNVYNVGYDLANLLATAGVGLDGDLVGTTKLSIGCDASSRTATLGNALADELGLDGHNHFEADTSLTRNDYFLANGDNHRLNTTLFTQMMQYCQGNCDLQHLALYREARYSASKADNGDFFFGPGSLLLYGAASFLYELMPTANGTADEATMMSFFGVGKVNGRYLANSGERLPPNWRARLDPYDNNKVGDQIFAMYNLHPVPFGGNVGPNNFLGLNYSSYVSNGQLNQQTADYAMCLIYQTLTGGFPAELGQLINFPVGVLGAMQQKLLGFGQSFGCPLNHNSGGSISGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRS4</accession>
    <name>N1PRS4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_79559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRS4"/>
    <dbReference type="STRING" id="675120.N1PRS4"/>
    <dbReference type="eggNOG" id="ENOG502SJJF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024934_8_0_1"/>
    <dbReference type="OMA" id="HWRESHG"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022698">
        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110061" description="C2H2-type domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="54823" checksum="F0B26BA831975D72" modified="2013-06-26" version="1">MKPSTPCTLRNLVPFQVLLCVQCGYCVLPRALDRHLKCIHNMGWVERRGHMEEVQGLELVSSEDVTYPHPDSQPVRGLPILQGHACGAPGCHHLCMTRKRMQAHWTSKHAKSTKTSERARSRLVKMQTFFRGSGLRYFRVAHDSKHNVSAQPTSDADSNLPLARDPSGGDEDTDIEWLLIKKFHEHSFLSVRPTKSTRQSWRDQMLQVGASIGFLRYAILSITASHVAYEHPDVRWMYGPQADRYRELATKSLFDPSAPAVKQENFFEYFNLQRLMTLCHISKTQLTQWEDCLSASAEQPVLPEWISVQRSGRALIWQHRGNGRVVEAMHGPGSCLYHDVYLLPETGVSHNPSDVYLRTLETDFASSSDFAVDESCLEALRMLRRVWEVPYRGQLVSFRDMALMWTARIPDTYVDLVKNHDPAALIILAHYCVLWSMCEDSFWYMKYHAARMLLVASRSLHLEMEDWIAWPLYMVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRX4</accession>
    <name>N1PRX4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho GEF GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rom2</name>
        <name evidence="6" type="ORF">DOTSEDRAFT_71021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRX4"/>
    <dbReference type="STRING" id="675120.N1PRX4"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001251_6_0_1"/>
    <dbReference type="OMA" id="CFRQKII"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="519"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="894"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME45169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1221" mass="138082" checksum="B4168DAA19894343" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSS6</accession>
    <name>N1PSS6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_109017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSS6"/>
    <dbReference type="eggNOG" id="ENOG502R98C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2090466_0_0_1"/>
    <dbReference type="OMA" id="RWRSADQ"/>
    <dbReference type="OrthoDB" id="4775599at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="117" mass="13241" checksum="824C62F109F41644" modified="2013-06-26" version="1" fragment="single">LVNYYFVFLALVVCIAGVAAYLMYKRKKKYGAFLASSRGHALESDVGTYNTRTRSRHWQGRWRSADQGREEGLNEYGEAPPPYMPKTEQEHSNPNVLAVPMQTLSRDAAGLNKPPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTB4</accession>
    <name>N1PTB4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_70645</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PTB4"/>
    <dbReference type="eggNOG" id="KOG1856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001680_0_1_1"/>
    <dbReference type="OMA" id="GYFYLCF"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001073">
        <property type="term" value="F:transcription antitermination factor activity, DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000007">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="1231"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1192"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1192"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1209"/>
            <end position="1223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME46706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1426" mass="163865" checksum="503FA3CE8D9B997E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU41</accession>
    <name>N1PU41_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_61094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU41"/>
    <dbReference type="STRING" id="675120.N1PU41"/>
    <dbReference type="eggNOG" id="ENOG502RYWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030268_0_0_1"/>
    <dbReference type="OMA" id="MDRASWY"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF11">
        <property type="entry name" value="PLD PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="434" mass="49179" checksum="3DC1DA8882C1294F" modified="2013-06-26" version="1">MQNQSIADIRDITFGTGYNIYHDSILPAIEAAQHEVILITCFWARSQTLDALNETLLKLSSNALKHQKRIKVRIGFSSSSLLQKLLHTSSPAGHTYDPSQWTTRLWLPSKEDLGGLDLEVKSIFFLPFSVWHPKCLIVDGRRVFLPSCNVSWEDWFEGCVEMSGPIVEEFMAFWREQWANGGENQPALDSSSAPHALALEVEGVGDATEPSMRMNDIPCKFLPSWHSRNPQWRLPMQQYAPPARTPLNIQLLEMFDNAKEEIFLQTPNVTAPPVLDALLKALKRGVNVEITTSERLMVLEQLVTAGTTTDRCMKSLIKEHERSLHQPLDEESGLATLGRLDISYYEPSPEQERESSEMAEPMQSHLKLTIVDNNTIVLGSGNMDRASWYTSQELGVAFISEKLCQQTKQKLKAAMKGHTKQVYDQDQSWDTRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUR0</accession>
    <name>N1PUR0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Versicolorin reductase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Dothistromin biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_125319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUR0"/>
    <dbReference type="STRING" id="675120.N1PUR0"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="VYLCCHH"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME46134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="241" mass="25684" checksum="57F78AE7E06730E0" modified="2013-06-26" version="1">MASAMARQGAVIFGCDINLEAANRAADMIRNEEEDVTKKEACKAFVDACMTKHGRVDVLVNNVGKSEPGGPAELTEDIWDAQTDVNLKSVYLMCHLVLPIMEKQSTGGVVLSVSSVAGLRYIGKPQVAYAATKAAIIQFTKTTAVIYAQRTGGKVRLNTVVPGLINSPLVSVLADKYAGGDQEGYRKVRDNQVPTGRMGSVWDVAHAALYLCSDEASYVSGQEIIVDGAVTNSTGQPDMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUW3</accession>
    <name>N1PUW3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUW3"/>
    <dbReference type="HOGENOM" id="CLU_2497873_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="86" mass="10052" checksum="D3A25F7168ECF474" modified="2013-06-26" version="1">MQRGSYRTMSKVTDASDCCQAAVDFTDLLWAVEELLYKTTVMATSPCRDRTRPPRRDEPWDGSRLVRWKKRLLCTRQSTANRYHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV12</accession>
    <name>N1PV12_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spherulin 4-like cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_52166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV12"/>
    <dbReference type="eggNOG" id="ENOG502SHPJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060605_0_0_1"/>
    <dbReference type="OMA" id="AMHGIFF"/>
    <dbReference type="OrthoDB" id="5342184at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF9">
        <property type="entry name" value="4-LIKE CELL SURFACE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32171" checksum="5FB0D34B60E7AB88" modified="2013-06-26" version="1">MELPQRPARQSRSRKCLCIGIPILAVILLLVIIVPAAVILTEKRGSIGLPSTILLPLYLYPTNDAWKPLYKAIEKAPKLNFTVIVNPSNGPGGMTDLMHFKPALQKLAAFRNVQTVGYVTTENGTRSTGEVQQDILKYSTWSNMPLNCTLNGIFFDNTPYVEDEETESYLVTINHWAKTAPGIYQPKMVIHKSTEMSPLALLNGADIMVGEWSYDELRESQASWDMEKDRSHLGFVVNSVPESASMKDLVKDMSRSGEFLFATESSKGDAESFGERWKDFVDAMEKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV68</accession>
    <name>N1PV68_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_50786</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV68"/>
    <dbReference type="STRING" id="675120.N1PV68"/>
    <dbReference type="eggNOG" id="ENOG502S2ZV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513891_0_0_1"/>
    <dbReference type="OMA" id="CYMLTIT"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="241"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="333"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="475"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME47371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="530" mass="57016" checksum="FDE45BCD0731B854" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVF0</accession>
    <name>N1PVF0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_101803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVF0"/>
    <dbReference type="eggNOG" id="ENOG502S0A4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089054_0_0_1"/>
    <dbReference type="OMA" id="CSQFFVG"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="190" mass="21717" checksum="4F77CF71EA1FEE92" modified="2013-06-26" version="1" fragment="single">RRNAATYRRTRKALRVKLDPSFAPSTTETQDHIIFNPPSSAPNVYHTPTKFLPTSDPRRALHTPAQIPANAPAARQGVLASIAAQRAAVAPSAQSLKPVRPIQEKKYHLAQAEIDEIRRLRAEDPRQWTRARLAEKFDCSQFFVSLCCSAPEIKQEQDEELQQIKAKWGRRKRDARDARQERKKRWGMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVN4</accession>
    <name>N1PVN4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_97416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVN4"/>
    <dbReference type="HOGENOM" id="CLU_1754040_0_0_1"/>
    <dbReference type="OrthoDB" id="10685483at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="149" mass="14975" checksum="0CDD84D03FC35F0F" modified="2013-06-26" version="1" fragment="single">TTTVLSVQPASTQFITSTQVSTAPASTVTQISTAPADTLTSYIVSTSVAPAVTYTSLQGTTTILSIQPASTQLITSTQISTAPGSTIVSTAPGSTITQTSLQVSTSIAPAVTYTSLVSLPQGTTTILSVQPASTQYITNTQISTAPGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVX9</accession>
    <name>N1PVX9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1264-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_146439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVX9"/>
    <dbReference type="STRING" id="675120.N1PVX9"/>
    <dbReference type="eggNOG" id="ENOG502QR3B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071931_2_1_1"/>
    <dbReference type="OMA" id="RHVEAHH"/>
    <dbReference type="OrthoDB" id="1901244at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25634" checksum="392B62F3F7798960" modified="2013-06-26" version="1">MDSIIISNGARGEPESLTNKTLETGAAMVQSFDPPRRLCAHLNAFHVYVNEPSRVSEANHYCAHVNNEVRQCLLYDSPLSTAKLIGVEYMVSERIFNELDPEEQKLWHSHVFEVKSGMLIMPIPAGVPPSAWEIAENKEMEQVVHLYGKVYNLWQTDRGDKIPLGQPQLMTSFTAKDQLDFERTVGDRDRRFGVDSKHKAEVRAYIEEPKIHANADALWKGKSRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWG7</accession>
    <name>N1PWG7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_69709</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWG7"/>
    <dbReference type="STRING" id="675120.N1PWG7"/>
    <dbReference type="eggNOG" id="ENOG502QRVH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050424_1_1_1"/>
    <dbReference type="OMA" id="TVWEVKD"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME47871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="332" mass="37054" checksum="D2C7B7078FD512DF" modified="2013-06-26" version="1">MGFGDFEEICAKTPLPLCPLVGTVSQISGTHSTYPECYARSIELANTIIFEGATGFAHILTLVMLVIMILHVRSKFTAVGRKEITSFFYSYTLLTMCSLVIDCGVVPPSSGAYPYFVAVQCGLVSSTCIALMINGFVGFQLYEDGTTLSVWLLRTCSVAMFLVSFAVSLLTFKGWGGLGPENTIGLFVVVYIFSAIFLFVYIVMQVILVIGTLQERWPLWHIGFGVMAFVIGQVLLYAFSKTICDNVEHYLDGTFFATLLNLLAVMMVYKYWDSITKEDLEFSVGQRQNNWEVKDHNMYEDIDKRGTYYQESDHGSTTHFAQPGHRGSGYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWH6</accession>
    <name>N1PWH6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_69640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWH6"/>
    <dbReference type="STRING" id="675120.N1PWH6"/>
    <dbReference type="eggNOG" id="KOG2208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012058_0_0_1"/>
    <dbReference type="OMA" id="MCFEMHG"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="278"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="506"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="574"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="661"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="848"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="910"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="984"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="853"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1036"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1046"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME47757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1070" mass="118295" checksum="B4FC32B962C6A6C8" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX52</accession>
    <name>N1PX52_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_69096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME46995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX52"/>
    <dbReference type="STRING" id="675120.N1PX52"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_3_6_1"/>
    <dbReference type="OMA" id="TYWVISF"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000042">
        <property type="entry name" value="Similar to amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME46995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="65333" checksum="37B17E36CB438C97" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXI1</accession>
    <name>N1PXI1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_124315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXI1"/>
    <dbReference type="STRING" id="675120.N1PXI1"/>
    <dbReference type="eggNOG" id="ENOG502SZT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089680_0_0_1"/>
    <dbReference type="OMA" id="FEQEKWH"/>
    <dbReference type="OrthoDB" id="5375264at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19259" checksum="9686715597F40B96" modified="2013-06-26" version="1">MIFPSAIEPAFTKTPANVKNDYVQSSSSRTVAAPPSSPRPSIAKKRTAPTPKMEVKKRKTGKKTMASRPIPRSLEECSEPDKMLIKMRDEGSEWGPIRKEWKELTGESTATSTLPNRYARLKSNFTVVREEDNALLLSAKREVEESFEAQKWDLVARVVAEKGGDTYAGTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXM2</accession>
    <name>N1PXM2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXM2"/>
    <dbReference type="HOGENOM" id="CLU_1948773_0_0_1"/>
    <dbReference type="OrthoDB" id="47488at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="129" mass="14533" checksum="EB0FA1BEAE814580" modified="2013-06-26" version="1">MLPTIAFSKWPDPRVQLCHRRRDFATMEGGAASLDSTILSSTTQVLLLISSRALQPTSLISFAHRIQSCFQRCKTIVDLPLTPRDSAVLQEGDYNRFQYVQPFKTLTAVSGLRSLDDFAGIRYTEQSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXV8</accession>
    <name>N1PXV8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_67431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXV8"/>
    <dbReference type="STRING" id="675120.N1PXV8"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_4_0_1"/>
    <dbReference type="OMA" id="DAGRLMF"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF8">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="60"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME48356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="480" mass="51688" checksum="A91620A515DC7DF8" modified="2013-06-26" version="1">MTDYGAARDGGYKNPDELSNSIPEHSSQDGSGFKDKEKFDPELALGEQLTVHEGEQKFKKLGWKALTICLIVEAIALGSLSVPSAFATVGMVPGVILTVGLGLVAIYTSYVVGQVKLKYPTVEHYADAVRLIWGRPGYELCGVMFALFLILIVGSHALTGTIAWIRIVNQPGLCALIFSVVSAIILFLLALPPSFHEVSFLGYIDFVSIIAAILITMIATGVEASNAPGGLSGVDWSLWPPPGTSLYEAFLSCTNIIFAYSFAVCQFSFMSEMHTPTDYVKSIWALGLIEIFIYTVTGAVIYAFAGSAVKSPALLSSSFTISRIAFGVALPVIFISGSINGTVVGRYIITRAFPNSSIRWVNNAKGWSVWAALIAAVTIIGWIIAEAIPFFNALLGLISSLFISGFSFYFPALFWFQLIKEGKWNANRHNIMLSIANGICFVIGVATLGLGTYASVKDIMSQYDSGSVRGSFTCDSSSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXW4</accession>
    <name>N1PXW4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_161842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXW4"/>
    <dbReference type="STRING" id="675120.N1PXW4"/>
    <dbReference type="eggNOG" id="ENOG502SEWH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087328_0_0_1"/>
    <dbReference type="OMA" id="QFDPRRN"/>
    <dbReference type="OrthoDB" id="4085451at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054448">
        <property type="entry name" value="HTH_put_ascomycetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22943">
        <property type="entry name" value="HTH_68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="2">
        <location>
            <begin position="153"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="212" mass="22613" checksum="1EA3282C470799F9" modified="2013-06-26" version="1">MGSSASKTAKVAGSAARKYPNRPAGTSQTPTATSNQRPSTNAPPPTPLAPQSQPGPRVKPRPYASGSRSEAIDLDASDPDFAQSLRSIGPVQPNPTLSPTSAFPPQPSGARPNAPNPRTNPAITVLDSRARLQQAAEAEFEEAGIRGHKGRQFLDVYQIRQILQLRDERGMNNGEIERRLGLKEGAVARLGPAGVVELAQEQGRAERDIRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY65</accession>
    <name>N1PY65_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_67492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY65"/>
    <dbReference type="STRING" id="675120.N1PY65"/>
    <dbReference type="eggNOG" id="ENOG502SXKU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115019_1_2_1"/>
    <dbReference type="OMA" id="YLATHMP"/>
    <dbReference type="OrthoDB" id="4892971at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02118">
        <property type="entry name" value="EthD family reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260:SF2">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11236" checksum="5539285D56C75BAB" modified="2013-06-26" version="1">MPATTTVVYPQGAKFNKEYYKSTHMPLVQEKWGKYGLKSWRVIFFGDDAPYCVQASLEWNSTQNFQDAASSPEAKEVLGDVPNFCDKDPVIMTAEVAFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYD3</accession>
    <name>N1PYD3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">DOTSEDRAFT_69369</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="27 28" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PYD3"/>
    <dbReference type="eggNOG" id="KOG0399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_1"/>
    <dbReference type="OMA" id="WDGPAAM"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="26">
        <location>
            <begin position="61"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="969"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1589"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1589"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1192"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1198"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1203"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EME47415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="2143" mass="236574" checksum="2EB566D63C879EB0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYH1</accession>
    <name>N1PYH1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain enoyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.3.1.93</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DOTSEDRAFT_39887</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.1.93"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="4"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYH1"/>
    <dbReference type="STRING" id="675120.N1PYH1"/>
    <dbReference type="eggNOG" id="KOG1639">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059260_0_1_1"/>
    <dbReference type="OMA" id="ATMPIFN"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000010">
        <property type="entry name" value="Steroid alpha reductase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="18">
        <location>
            <begin position="155"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EME48561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="305" mass="34162" checksum="9517B37CC0392F28" modified="2013-06-26" version="1">MASKPVNLQLKPRGKRIPGLPKETSTYIQGSTADLYHRIAAESRFDVHRLRITKEDGSLVPNDKKTTVDSLGLKDGSVIQVKDLGLQIAWRTVFIIEYLGPLLIHPIFYYGRPYIYAKASSPPSTLQTLSFITIMLHFLKRELETAFVHRFSNATMPAMNIFKNSGHYWILSGVLVAYFTYAPTAWAAGASSPLYIYLALALFVIGELGNLNTHLVLRGLRSPGGTERGVPQGLGFEWVTCPNYLFETVAWVGMVLITKSWATVLFAVVASSTMAIWAQKKERRYRKELGGKYQKKRFAMIPGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYK2</accession>
    <name>N1PYK2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DOTSEDRAFT_69850</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYK2"/>
    <dbReference type="STRING" id="675120.N1PYK2"/>
    <dbReference type="eggNOG" id="KOG3717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013513_5_1_1"/>
    <dbReference type="OMA" id="KMDGTPT"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="20">
        <location>
            <begin position="65"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EME48053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="641" mass="73197" checksum="5FF8177B81026CC4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZH6</accession>
    <name>N1PZH6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_123163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZH6"/>
    <dbReference type="STRING" id="675120.N1PZH6"/>
    <dbReference type="eggNOG" id="ENOG502RZSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_1_0_1"/>
    <dbReference type="OMA" id="WQAFHEA"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="367" mass="40262" checksum="AB9D5722C50B3E4E" modified="2013-06-26" version="1">MVNITSVDLMRLATSFDYAHSLQAITNASTDHVSFISYDPSFISNVVGLNATQELVAHLPHDAFHESGVYNIATGKIYAASNWAGSLDNPVNVTTIDLKNNHNIESVRYARLAEPNGGTAYYPPGTPANSSEGQQIVFCDEGDLQRGPSQLVAVDPAKNTTKVLLNNFLGRNFSSINDVEQHDITGDLWFTDARYAYWQYFGPEPSIRPQVYRFEPKTGVVQAVADDFIAPNGIEFSPDLKHVYVTDTGVHTFPGKDNATGPANIYRFDLTPDGKRLQNRQVFAYSDEGFPDGIHTDTLGNVYSATSDGIHVWNPAGVLIGKFGIGSPGSNNFIFVPGGMYIFNACKLWKITIKAEGRSVKREFGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZW8</accession>
    <name>N1PZW8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">proline--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_84523</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="4"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZW8"/>
    <dbReference type="STRING" id="675120.N1PZW8"/>
    <dbReference type="eggNOG" id="KOG2324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_2_2_1"/>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000066">
        <property type="entry name" value="Proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="86"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME49056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="628" mass="70014" checksum="D9467DD37DED05F8" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q004</accession>
    <name>N1Q004_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_86336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q004"/>
    <dbReference type="STRING" id="675120.N1Q004"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_5_1_1"/>
    <dbReference type="OMA" id="AYTKNQD"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000021">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="621"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="507"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME47980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="658" mass="71230" checksum="0D23AD4AC2AE7674" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0K2</accession>
    <name>N1Q0K2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_67751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0K2"/>
    <dbReference type="STRING" id="675120.N1Q0K2"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OMA" id="VMCQLTW"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF6">
        <property type="entry name" value="CYTOCHROME P450 2C30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME48803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="61151" checksum="34735EDEFF0DD31A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0Q2</accession>
    <name>N1Q0Q2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_124924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0Q2"/>
    <dbReference type="STRING" id="675120.N1Q0Q2"/>
    <dbReference type="eggNOG" id="KOG3328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_1_2_1"/>
    <dbReference type="OMA" id="LVMECET"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME48200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="107" mass="11937" checksum="C6E2F6A4DCBBAE5A" modified="2013-06-26" version="1">MVQPEFLNPMGTLHAGATSAFFECATTWALYPIAKPGFWQSLGICRTIAFTYLRPAMVGEVLVMECETVHVGKRIALLRGTMKRERDGVALVTCEHNKYNVDADMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0U1</accession>
    <name>N1Q0U1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_70002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0U1"/>
    <dbReference type="eggNOG" id="ENOG502SHZM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008599_1_1_1"/>
    <dbReference type="OMA" id="LQTMPEE"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="506"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="656"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME48245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="841" mass="93950" checksum="C5EC5ECE11BA9078" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q167</accession>
    <name>N1Q167_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_68311</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q167"/>
    <dbReference type="STRING" id="675120.N1Q167"/>
    <dbReference type="eggNOG" id="KOG3754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010467_0_0_1"/>
    <dbReference type="OMA" id="IAHMFIR"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000004">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME49501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="663" mass="75245" checksum="B61F329AB14ACF35" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q168</accession>
    <name>N1Q168_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DOTSEDRAFT_67444</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q168"/>
    <dbReference type="STRING" id="675120.N1Q168"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003662_1_0_1"/>
    <dbReference type="OMA" id="MIVAVNW"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000052">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000011">
        <property type="entry name" value="Sulfite reductase flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="684"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EME48385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1075" mass="118299" checksum="7DE2E9F262C378DB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q169</accession>
    <name>N1Q169_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_21916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q169"/>
    <dbReference type="HOGENOM" id="CLU_959856_0_0_1"/>
    <dbReference type="OrthoDB" id="10556822at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="290" mass="32080" checksum="7930BDC3B78E81D8" modified="2013-06-26" version="1">MNEIAALSAQTSTIPGSTQYSAISHMQNARLSRLPARIRTRIYELVLAEQKDIPISLVNRPKEISLGEVRHLWNRYPQMQAGCFRAEVLTCVPQIGGKNKHRPLHPHQGFPQTCRALRQETQALCLAEKAFVCHTRHLERTASGLASGEEGDGTFYHEALRSLGLGDIVGTVVEIVLDLGVAYSRCRAPAKIEWDAIIGVIWRRCRPDTVIKVVVTFDWTMVGAADRFSMSFEVGKAIVLKPADIEAAAVNSGSAAKLPFLKGYMLLRRLIGSLREFEVGERDSSGSSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1F8</accession>
    <name>N1Q1F8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1F8"/>
    <dbReference type="STRING" id="675120.N1Q1F8"/>
    <dbReference type="eggNOG" id="ENOG502S6BC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021798_0_0_1"/>
    <dbReference type="OMA" id="MLNRDCR"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="151"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="413" mass="44523" checksum="170646A5795C16B4" modified="2013-06-26" version="1">MPRPNPPPTPGSSSDIRGKEKSIQSVPTFNLPQTAFDEPDRRSTSSTTPSANGSDSSYRPVSPTSPAETLKKRPALQPGPVISKDDFALPPPPTRSRKIIQMKPRSSEQQEAAPRVSAPQTAGKAQTQAAQTGSKRKQNNAGTTAAGRKIARKTAHSLIERRRRSKMNEEFGVLKDMIPACKGQEMHKLAILQASIEYLRYLEQCVSDLQAQNTSPRPPPPSRQAENLDDEDDEDEEMEDRQDGGDGAATPAMTAPQKSASMVSLPSLSQITTTTTTSPSVFSMGTGRQYSISSAASSYSPYFHSNQASPAFGPQLHHASTAPPFGNAFGLGSPALKPIDSASQLRHIAEGANELSDKQRPTSNAGRREQELDQEATAALLMLNHDRRNWRNASEANPSRSNTGMSVKDLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1K6</accession>
    <name>N1Q1K6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_161884</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1K6"/>
    <dbReference type="STRING" id="675120.N1Q1K6"/>
    <dbReference type="eggNOG" id="KOG1066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_9_0_1"/>
    <dbReference type="OMA" id="LPRGRWY"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF165">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="7">
        <location>
            <begin position="37"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="252"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="8">
        <location>
            <begin position="614"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME48384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="853" mass="94679" checksum="D8E8A2DDBF8F5FE7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1M8</accession>
    <name>N1Q1M8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_67562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1M8"/>
    <dbReference type="STRING" id="675120.N1Q1M8"/>
    <dbReference type="eggNOG" id="KOG0569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="OMA" id="WAITASF"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="16"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME48555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="499" mass="52391" checksum="74B493FDB21D4F76" modified="2013-06-26" version="1">MAIKPLGDLTPSFVYLLLTATLGPLLFGYHLAELNAPQEVITCAKKSIDASTLAHVKSVFGTKAAASAGFLPQCISMSPVEFGLVSSFFTLGGLIGSLSAGPITAKQGRLRAMIYSSMFAAIGPIFEAAAPNITVLTIGRFISGVGAGAATVVVPIYISEISPPDKRGFFGAFTQILTNCGILITQGLGLFLSRGQLWRITLAVGGAIAVIQAVGLTLGGQESPKWLAENGQPSKGKNILRKIRGDSPDIEDEMSTWNIAAGHQVDGEEERLLGQPANSNAGTSIGVFGVLQHPDTRPAVIAVVMIMVGQQFTGINSIVMYGVGLLSDLLAANSAYLNVIVAGVNVIITTSCAPLSDRWGRKACLLISISGMGISSILLAIGIMQSIKVLSAISVILFVASFGFGLGPIPFILAAELVNTEAVGATQSWALAANWTATFIVAQFFPLLNEKMGKGQVYFIFAAAAVVFGTFIAWRVPETKGKRDADEVWARKKAPDLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q250</accession>
    <name>N1Q250_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RIC1 C-terminal alpha solenoid region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_68585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q250"/>
    <dbReference type="STRING" id="675120.N1Q250"/>
    <dbReference type="eggNOG" id="KOG2006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002060_1_1_1"/>
    <dbReference type="OMA" id="MVYDRAM"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="4">
        <location>
            <begin position="832"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME49836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1082" mass="118314" checksum="06887AE11C448A5C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2P4</accession>
    <name>N1Q2P4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G protein alpha-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">gpa1</name>
        <name evidence="13" type="ORF">DOTSEDRAFT_68770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2P4"/>
    <dbReference type="STRING" id="675120.N1Q2P4"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="OMA" id="QVIWADA"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME50021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="353" mass="40618" checksum="ADF77AE1C66E3378" modified="2013-06-26" version="1">MGCGQSSESKEGKQRNEEIENQLKRDKMNLRNEIKMLLLGAGESGKSTILKQMKLIHEGGYSRDERESFREIIFSNTVQSMRVILEAMESLELPLDDQRAEYHVQTIFMQPAQIEGDVLPPEVGQAIKTLWADAGVQAAFQRSREYQLNDSAKYYFDSIDTIASPTYIPSDADVLRSRVKTTGITETTFIIGDLTYRMFDVGGQRSERKKWIHCFENVTTILFLVAISEYDQLLFEDETVNRMQEALTLFDSICNSRWFTKTSIILFLNKIDRFKEKLPVSPMKNYFPDYEGGQDYGAACDYILNRFVSLNQHPTKQIYTHFTCATDTMQIRFVMAAVNDIIIQENLRMCGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2X9</accession>
    <name>N1Q2X9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 30 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_121716</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2X9"/>
    <dbReference type="STRING" id="675120.N1Q2X9"/>
    <dbReference type="eggNOG" id="KOG2566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014379_3_1_1"/>
    <dbReference type="OMA" id="GLMWNFA"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="5">
        <location>
            <begin position="16"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME48844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="541" mass="60016" checksum="E61C237E15934508" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3Q4</accession>
    <name>N1Q3Q4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_68595</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3Q4"/>
    <dbReference type="STRING" id="675120.N1Q3Q4"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_1_1"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME49853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="426" mass="46608" checksum="2ADA747BDB77D5F9" modified="2013-06-26" version="1">MATPSLRTLLPRLASRLGSACQKSSRCAISPAAERAYSTPLRAPDASDPRLSRIDVSGLSITKTTAPKPITPNEELVFGRAFTDHMMSLEWTATEGWLPPRITPYQNLSLDPATCVLHYAFEAFEGMKAYKDKAGNVRLFRPDKNMARMNKSVSRIALPTFDGEAVIHLIKKFANMEQRFIPSKRGFSLYLRPNMIGTQRTLGVGPPGSAMLYVIASPVGPYYPTGFKAVSLEATDYAVRAWPGGVGASKLGANYAPCIVPQMQAASRGFHQNLWLFKEVDPATGIEEDYVTEVGTMNLFAAIVNKEGQKELMTAPLDGTILEGVVRDSVLALAKERLAPQGWKISERRFGMRELVDAANEGRMIEVFGSGTAATVSPVRAISYKGKLVDCGIPEGEEVGPVCLQMKDWIEGIQYGEEEHPWSVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3U0</accession>
    <name>N1Q3U0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_50071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3U0"/>
    <dbReference type="eggNOG" id="ENOG502TA36">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_611141_0_0_1"/>
    <dbReference type="OMA" id="HDNHTST"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="448" mass="49987" checksum="CAE802F02051439D" modified="2013-06-26" version="1">MAACRVDPMPPRTLPDRTAHDNHTSTKYIGRSSGPVQPSPLDAALLCSKLNLHKREQDALRRSREKRELFRNGQYVPKNAAKSFTATTRAMHHEMTPPFRRRKQIPGPLPMIAEPVEGKALRCQKQQHHAILDSAPVTRSTELALRGTSIRNAAGLTEEPTMIELEEGEPEAARISRERFDLTAALAEIEPHPFAAERHDSTRNSARSQKHDSIDPPAADSRAPDFHSLVTPDQPELQPLAKMPSLPDLQSLPGLEPTPPRRRSSAGSEELDSAGRGRAGYRPGDAAKRRSIIDPLSRAQRDRSTSSSHHCGTRMSRSVEEEEAAVLNSTIPEVDTPAVVQRPQLTSNDRPDWSQRSETGDEARHAFNLHVFSHTEKKSQRPQGALLENSMVAQFAQPKPAEQPRRPSETKIYRGPQNDHLIADAVKIIQRAKKVKRRASVMEFFKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3Y0</accession>
    <name>N1Q3Y0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3Y0"/>
    <dbReference type="eggNOG" id="ENOG502SD6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1061867_0_0_1"/>
    <dbReference type="OMA" id="KHRKWRE"/>
    <dbReference type="OrthoDB" id="3649695at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29807" checksum="549069DB679B30C7" modified="2013-06-26" version="1">MSAADYYNPGGQQPGPGFSQPANSNHLNPNPPYPMSDAPPPYSVEPPRPHSQPPPQHRPPPPPHDQYWRAPPPPSGPSPINGHYPPEKSSRPTPQFETSDFTGPGSYAQRNGQKHPQYQQPQGYFPLAGSPAMQQVFGNGGADPNGRRPSTTPGYRPLASPYRDDYYRGTSRSRSRSRSRHRRHHYHDRPPTQRKKSSGVNTFLGAGGGAILGDAIFPGLGTLGGAILGGLGGHEYSKKKKSHSNPPSKMRDRSYSNDGEYYEDHRRGRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q484</accession>
    <name>N1Q484_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_76700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q484"/>
    <dbReference type="STRING" id="675120.N1Q484"/>
    <dbReference type="eggNOG" id="KOG1587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012999_2_0_1"/>
    <dbReference type="OMA" id="MHDRPEY"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="496"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="675" mass="74996" checksum="A8134A85030DE4C2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4I5</accession>
    <name>N1Q4I5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_30891</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4I5"/>
    <dbReference type="STRING" id="675120.N1Q4I5"/>
    <dbReference type="eggNOG" id="KOG2414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_1_1_1"/>
    <dbReference type="OMA" id="DSYFWYL"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="12">
        <location>
            <begin position="66"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME49705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="491" mass="54419" checksum="0FA5EB569600A104" modified="2013-06-26" version="1">MDNMRRSCSSLLRSISRPTPTFRTRPCCAQLNNNRTLVSAAEIQFGQPLHETHPHLIQPGDLTPGISALEYHHRRAALARKLPRDSVAVLAAADVKYRSGAVFYDFHQESNFFYLTGFNEPDAVAVIEKGQSDVEYTFHLFVRPKDERAELWDGARSGLQAAQDVFNADEVGSIDDIGTLMPEIINGARSVYTDIGYTGRKTALSRFLQGQPKVDGMAKLMQNVVAKPLRSMLNELRVVKSEAELGCMRKAGSVSGAVLTEAMKRTPRSEKQLWADLAYGYRTNGLDGEAYVPVIAGGKNALSIHYVRNDALLKSGEAVLVDAGGEYGGYITDITRTWPVNGRFTDAQRDMYNMILNVQKSCVSLCRADAEMTLDKLHRVSENGLRDGLKSLGFDISGDTLDKLFPHHVGHYIGLDVHDAPGYPRTDLLKPNHCITIEPGIYVPDNDRWPAHFRGLGIRIEDSVVIGEDRPEVLTRAAVKEVAEIEALRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4J3</accession>
    <name>N1Q4J3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_165395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4J3"/>
    <dbReference type="STRING" id="675120.N1Q4J3"/>
    <dbReference type="eggNOG" id="KOG2050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013994_1_0_1"/>
    <dbReference type="OMA" id="YGPEFSI"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="110"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="642"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME50283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="676" mass="76217" checksum="CBC2330E32543D57" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4S8</accession>
    <name>N1Q4S8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_40843</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1Q4S8"/>
    <dbReference type="eggNOG" id="KOG3600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002210_1_0_1"/>
    <dbReference type="OMA" id="DRCTLFG"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="15">
        <location>
            <begin position="900"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="13">
        <location>
            <begin position="1096"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="555"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="597"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="826"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1235"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1246"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1274"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME49679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1425" mass="154310" checksum="C8AD6FB1FA046DEC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4W2</accession>
    <name>N1Q4W2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_68685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4W2"/>
    <dbReference type="HOGENOM" id="CLU_2542548_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME49945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="83" mass="9366" checksum="EA6ED83BA291274E" modified="2013-06-26" version="1">MPTPHVDTLQHRNDGMVTMIMQTRASISDTPARALATHSFRCARNVVHAHTIWPEGRDQGNSMWRAVASTREHISCCILRTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q562</accession>
    <name>N1Q562_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_50175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q562"/>
    <dbReference type="STRING" id="675120.N1Q562"/>
    <dbReference type="eggNOG" id="ENOG502QT5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008292_0_0_1"/>
    <dbReference type="OMA" id="RGPMTRK"/>
    <dbReference type="OrthoDB" id="2117591at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017210">
        <property type="entry name" value="APP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037464">
        <property type="entry name" value="UCP037464_APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="354"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME50034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="911" mass="100753" checksum="D7DA5D760B4B3492" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2WNK9</accession>
    <name>M2WNK9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WNK9"/>
    <dbReference type="STRING" id="675120.M2WNK9"/>
    <dbReference type="eggNOG" id="ENOG502T2Y3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_1_1"/>
    <dbReference type="OMA" id="FSANHAR"/>
    <dbReference type="OrthoDB" id="4850726at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="108"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="657" mass="73702" checksum="42683AACF8079531" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2WNU7</accession>
    <name>M2WNU7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WNU7"/>
    <dbReference type="eggNOG" id="ENOG502SD76">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047846_0_1_1"/>
    <dbReference type="OMA" id="ENVPIYN"/>
    <dbReference type="OrthoDB" id="5405126at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="373" mass="41766" checksum="967AA8BD39617D01" modified="2013-05-01" version="1">MASLCNRCALRLRKAAQTETSHLSKRTFSSSASRQRGPLPTFNEASNEELNNVLSTMREKHFVPAYMHKQEHKLITKSKYRQQLIDNPQTGIVGGEEITLRPIDTRTEIPARGGLLARALNLIINGESKDWQNIPKLLQGLKEGVKKPATDAQMEKIVRKGFQTKQLGVIIQCLYQAEQTGMTLKSEAVLRTFLGGLHDLAQQSGWQKGAVSKALREVNVVSQLLEAKEHGTGGTLRPHDPRTRPEVLGVFLELAAVYAYKYDGQTDSEGLVKAYARRLISNIEKSQMKPSELQLLERSKQWPMLQAIPVWHGLSLAEKMLGKEMPERQAASKAIAEYEVALRGLAAELEARNPAEGTYDYQALNAWRQCIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2XLD6</accession>
    <name>M2XLD6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF410-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_80727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XLD6"/>
    <dbReference type="STRING" id="675120.M2XLD6"/>
    <dbReference type="eggNOG" id="KOG3024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046061_0_2_1"/>
    <dbReference type="OMA" id="LMDMMGM"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37130" checksum="B442CCFCBECA0E0A" modified="2013-05-01" version="1">MSAAKIQKVLARQQAKIEEGDFYEAHQQLRTIANRYVKSQDWPAAADLLSNGALMLLKAGQGGSGSDLCTYLMEVYQKAEFRADVANKARILSLLRAFPPNEPSKKKFVTGIVEWSAKYSDFPAGDPELHHVIGSLYAEEGETYDAERHLTLGTSDSASALADMEYEWYASDEPSTASHYAARAVFPYLLIGNTRAANKALLLFTSRLSSLHPGLGVQSISSPSSDIRIYPSLPLLNFLGLLLLAIQRGTKDLFNQLKTHYAAHLKEVPHWDEPLLQIGEMYFGIKIPSQSNPMFDMMSSMLMGGSNPFAAKKKESRQVTAGNATPSASETPAPAPTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2XLI6</accession>
    <name>M2XLI6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_103152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XLI6"/>
    <dbReference type="STRING" id="675120.M2XLI6"/>
    <dbReference type="eggNOG" id="ENOG502SEIT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2418981_0_0_1"/>
    <dbReference type="OrthoDB" id="4586300at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="92" mass="10319" checksum="DB0367B6C34E4969" modified="2013-05-01" version="1" fragment="single">AEDLKKVEKSQAAPEGAPVLVEKPQVLSALTTSQTTRLPDGTVTTKVILKRRFADGREETEESMHTSKEPSVEQQKQQPEAEQPKQKGWFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y167</accession>
    <name>M2Y167_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_75669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y167"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_1_1"/>
    <dbReference type="OMA" id="WTMVVSS"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="90"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME39049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="577" mass="63223" checksum="64BB51DD626E9D37" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y332</accession>
    <name>M2Y332_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_75372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y332"/>
    <dbReference type="eggNOG" id="ENOG502S04M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035511_0_0_1"/>
    <dbReference type="OMA" id="HEMLPCP"/>
    <dbReference type="OrthoDB" id="2392789at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="589" mass="65331" checksum="2F96F4A00A25D60F" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIK7</accession>
    <name>M2YIK7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_66760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIK7"/>
    <dbReference type="STRING" id="675120.M2YIK7"/>
    <dbReference type="eggNOG" id="KOG2666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_7_0_1"/>
    <dbReference type="OMA" id="CHALVIH"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="294"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME38746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="489" mass="52863" checksum="9208F44661150714" modified="2013-05-01" version="1">MTRSCIERGLICCIGAGYVGGPTCAKVTVVVLNQDRIDAWCSNDLPVFEPGLHDIVTLAREGTGSRRPNLFFSTNDSQAIDEADLIFISVNTPTKTTGTGAGYAPDLAYNDKIIVEKSTVPCGAASSLRAIFDALAPSLRFDILSNPEFLAEGTVVKDLLDPDRVLIGSLPDERSIAAMAALADIYSTWVPRSRIITINLCSISSFSAICEATGANVGDLAHAVGMDSRIGSRMLKPSVGFGGSCFKKDVLSLVYIAECLHLPEVAQYWQSVVSINEYQKNRITKRIISRLNNTLWGKKNTRESAAISVIHQLLQEKAQITVYDPKVSSEAVFAALEHQPPSRDATPDMIRSSITVCSGATTACANASAVVILTEWDHFKTDKIPVCFEEESLWSAGSDGEAASTDTVSSISSKDSGIDVETPLIEQKSSQSLDKLAESERIDWVSIARVVRKPGLVFDGRDVVEPAKLAKLVFRVECIGKPTTMIHAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKB5</accession>
    <name>M2YKB5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_139435</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKB5"/>
    <dbReference type="STRING" id="675120.M2YKB5"/>
    <dbReference type="eggNOG" id="KOG2431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_3_0_1"/>
    <dbReference type="OMA" id="AAFKHSW"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="701"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="552"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="640"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="435"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME39411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="728" mass="82308" checksum="B3DD4ECE69462740" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKC9</accession>
    <name>M2YKC9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mnd1 HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_138647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKC9"/>
    <dbReference type="STRING" id="675120.M2YKC9"/>
    <dbReference type="eggNOG" id="KOG3433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080628_0_0_1"/>
    <dbReference type="OMA" id="VCYWAFP"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="3">
        <location>
            <begin position="35"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME39426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="236" mass="26993" checksum="C958ADCEDEF48A06" modified="2013-05-01" version="1">MVNSSLLSSPPPLRTDSISQPKATCNPEKLRNAVRFLQKSRTCWNIKELEKQLTSVCSINGMQVKDYLQNLQDENLIKVEKIGSGNWYWSFASEARINKEAALAAVQKEHNKCSAIVTELQHEVATTAAALEEEADSPDHGGESREEMNARKVVLVDETKGLEEELKSFAEDDPTELERKKQEAKKWLREAEQATDEIQTMEMWFKKNHPEMGAEMAMAFDYGDEWDLEEYCFKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLG8</accession>
    <name>M2YLG8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_131895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLG8"/>
    <dbReference type="STRING" id="675120.M2YLG8"/>
    <dbReference type="HOGENOM" id="CLU_010595_0_5_1"/>
    <dbReference type="OMA" id="DNFIGCS"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30404" checksum="B24978B39AD313CA" modified="2013-05-01" version="1">MDAGHFVYLLMESGRDNPLFRSPLRSSRNVLDVGTGTGTWAIDVADKSPDANVYGIDLYPPPNSWVPPNCFLEVQDILQEWTWNHQFDLIHLRLMLGGFTDAEWDQVYRTIYDNLKSGGWIEQVELDVRVMSDDDSLPKDSLLAGWGQNFLGCSERSGKLLSTQTTMAGRITAAGFVNLQDDLFKCPLGSWPKDVRLKEAGRVNFHHWSSGLDGWAMWLLTKHGAPTPWSADEVRVYVAKVRQELKQKDLHIYHFTRRVWAQKPLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2YMS0</accession>
    <name>M2YMS0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YMS0"/>
    <dbReference type="HOGENOM" id="CLU_2512612_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="85" mass="8945" checksum="CBB95CAE4C7361B7" modified="2013-05-01" version="1">MVRSTHLGQCFLLSAYDEASEQAAGPLQMHSTPVLRRNAAVATMGDSAGVVTLRVRQYTPQTGTLRATSSSLWIGNADSGLLGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>M2YN94</accession>
    <name>M2YN94_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_72729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YN94"/>
    <dbReference type="STRING" id="675120.M2YN94"/>
    <dbReference type="eggNOG" id="ENOG502S0Z0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005620_1_0_1"/>
    <dbReference type="OMA" id="WAMTLFN"/>
    <dbReference type="OrthoDB" id="4489171at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="526"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="821" mass="90888" checksum="28327C11495A2427" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2YNK6</accession>
    <name>M2YNK6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_25523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YNK6"/>
    <dbReference type="HOGENOM" id="CLU_2038019_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="121" mass="13330" checksum="D279BF1DBC34650E" modified="2013-05-01" version="1">MPNPFTETQIQTSPPATPTDKKPFDNHAQLSMPTIIETPFEPDRPQPWQPPNVPPPVPNPELSLPFEPNRPYPWQPPSVPPPVPNPELSRSNSEPHGPGMPIPDPHPGKPDPDAGPLRSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBQ6</accession>
    <name>N1PBQ6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">Glutathione reductase</fullName>
            <ecNumber evidence="3 17">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DOTSEDRAFT_181781</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 17">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 17"/>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBQ6"/>
    <dbReference type="STRING" id="675120.N1PBQ6"/>
    <dbReference type="eggNOG" id="KOG0405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_2_2_1"/>
    <dbReference type="OMA" id="MSKHYDY"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000141">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 14 16" id="KW-0274">FAD</keyword>
    <keyword evidence="6 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="8 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11 16" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="19">
        <location>
            <begin position="9"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="18">
        <location>
            <begin position="353"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="15">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EME38552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="465" mass="50822" checksum="9D75BF1840B99336" modified="2013-06-26" version="1">MAPIQKECDYLVIGGGSGGLASARRASGMYGAKVIAVENKRLGGTCVNVGCVPKKVTWSAANIAETIKDAKAYGFSVEQTAPFDWTTFTEKRAAYIKRLNGIYEKNLKNDKVEYLHGTASFQDPHSVRVELDDKSHVDIKAKKILVAVGGFPNIPSNIEGADLGITSDGFFEISKQPKKVAVVGAGYIAVEMAGMFHALGTETHLFIRHDKFLRTFDPMIQDKVVAEYERQGIILHKQSSQSKVEDAGNGWKKLHYKDQNGEGTLDIDCLLWAIGRSPELTKLNFDVTGVKLNDKGHIPVDDYQNTNIDHIYALGDVCDKGFELTPVAIAAGRRLSDRIFGGQKDAKLVYENIPSVVFAHPEVGSVGMTEPEAREKYGDDIKVYNTSFTAMYYAMMEQDEKGPTAYKLICAGKEEKVVGLHILGVGSSEILQGFGVAIKMGATKADFDRCVAIHPTSAEELVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBQ9</accession>
    <name>N1PBQ9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_100738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBQ9"/>
    <dbReference type="eggNOG" id="ENOG502SAKB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061825_1_3_1"/>
    <dbReference type="OMA" id="MPEIPTT"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="193" mass="21026" checksum="00BA7E17CC62093E" modified="2013-06-26" version="1" fragment="single">SFPKFHCFVSNQTGNTVLFAVSAFSLFGTRQQTDFTVPVTHLAVSLGFFCLGVFTAGQIANRLDCKSRRWWLILTNACQTAMFLIAALLNLVYRTGNQPADEGLVNSASILCPIGLLAMASGMQVAMSRQLSMPEIPTTQATAAYVDLFVDPNFFAGICHNRSRNRRVLFLLTLCVGSFIGAPAYHYVSTALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBU1</accession>
    <name>N1PBU1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_74618</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBU1"/>
    <dbReference type="STRING" id="675120.N1PBU1"/>
    <dbReference type="eggNOG" id="KOG1875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003573_0_0_1"/>
    <dbReference type="OMA" id="ITQGYIP"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="104"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1044"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1051"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME39773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1110" mass="122081" checksum="7841297FBB152D14" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBY8</accession>
    <name>N1PBY8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_161092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBY8"/>
    <dbReference type="STRING" id="675120.N1PBY8"/>
    <dbReference type="HOGENOM" id="CLU_1643663_0_0_1"/>
    <dbReference type="OrthoDB" id="3647597at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME38253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="161" mass="18058" checksum="290EAC4D1AD3AF36" modified="2013-06-26" version="1">MSDYTLVNTYKRYKAGTQKLVRWLTESASRCHTDSPNSSRKPRVARKIRTAELVACTEHIVAAKDPRVEVPPDILDVTKVVITGCTCCVEFYASLSQGADLDPSLLAANASHKHFLGVRVQIFDILTKEHETRRPERRKEDARAYNRRGRPGGSIPAPRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCR3</accession>
    <name>N1PCR3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_27783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCR3"/>
    <dbReference type="eggNOG" id="ENOG502QXCY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1343209_0_0_1"/>
    <dbReference type="OMA" id="YECAPDS"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="204" mass="22625" checksum="338501A2553B5ACF" modified="2013-06-26" version="1">MMIQQDNRQHSRWLGNHAPAQVHERFGTLSWNPGGPGLSSISDMSLGRAFSPYIIRHFDLVAMNVRGLDNIEPAHYNMTLSLKPFNSPPVLQTEEAFHKHVADRMLLARSCTDGTGNASNYECAPDSMTVVNVAKDFEIARQLVGDDKVTSAGFSWGSVIAATYAELFPSKMRTLVLDGVLHRWPQDLTDATSSRCTAQNVEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCS8</accession>
    <name>N1PCS8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_74987</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PCS8"/>
    <dbReference type="eggNOG" id="KOG0916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000844_0_1_1"/>
    <dbReference type="OMA" id="AWTDFFI"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1340"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1392"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1509"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1599"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1642"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1681"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1715"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1779"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1842"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="343"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME40368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1920" mass="219674" checksum="5FFE59B8FD33B474" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDU1</accession>
    <name>N1PDU1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_83788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDU1"/>
    <dbReference type="STRING" id="675120.N1PDU1"/>
    <dbReference type="eggNOG" id="ENOG502QUKB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_946727_0_0_1"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="294" mass="32558" checksum="6E702A0295B858DC" modified="2013-06-26" version="1">MHETRHRPHDCREWVRTWSAREDMVGTRLGGWWEKNWAMIDGSLGPGGRPHRHISAKPAGKMSTGRDNEISSTFTPITFQSLPTAELRLPRLVEDESKCNIETIIDMACAPSRQEKLEPLVSKGRSSYRHPAIAGLVSALPSSVLQRREDRWPYAPFTTSGRDIKNTQGETVTNAGANWPGDADSMLPEGLQYQSVANIVSKIKSLGMDTIRLTYAIEMVDDIYSDNIDSSLEGTFVNALGQENGTKVFSQFPITTPSSVRTLPDSSLLLLKKNIPSTNTFTMPAKRNANAVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE06</accession>
    <name>N1PE06_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE06"/>
    <dbReference type="HOGENOM" id="CLU_2573865_0_0_1"/>
    <dbReference type="OrthoDB" id="3636394at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="81" mass="8898" checksum="6AD660F8F4F83644" modified="2013-06-26" version="1">MNATKSAQEAFKAGFDDSGKSLETHIGPKDVGKPNQTMTAVHLSLCAEWHFSEPHQPYFSFTGHDVGGDASENARERMGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE09</accession>
    <name>N1PE09_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_178630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE09"/>
    <dbReference type="STRING" id="675120.N1PE09"/>
    <dbReference type="eggNOG" id="KOG2750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010345_1_2_1"/>
    <dbReference type="OMA" id="PEFAPMG"/>
    <dbReference type="OrthoDB" id="4054781at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="9">
        <location>
            <begin position="168"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME39805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="538" mass="58978" checksum="36DBE8547DDF5E0D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE42</accession>
    <name>N1PE42_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_48665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE42"/>
    <dbReference type="STRING" id="675120.N1PE42"/>
    <dbReference type="eggNOG" id="ENOG502S2AQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150771_0_0_1"/>
    <dbReference type="OMA" id="YYRYGGM"/>
    <dbReference type="OrthoDB" id="537467at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="108" mass="12216" checksum="94530E5F958E070D" modified="2013-06-26" version="1">MPRPVLVRCQIDETGSWNFVCPGACWRSVCGGEEDARGMEKEYPYYRYGGMWKNKHTDGPASAKKPKKVKEKQKERRAKRKEALAKSSEQSDEDGGRSEETTGEGLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEQ0</accession>
    <name>N1PEQ0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_37584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEQ0"/>
    <dbReference type="HOGENOM" id="CLU_799321_0_0_1"/>
    <dbReference type="OMA" id="MECESGR"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39140" checksum="2DC429FDAB13B353" modified="2013-06-26" version="1">MQLLKALFPSHDQGRDHRKLDTGTTVERHSTGWRWPSTPLKRRPSSEIAAESKRSSTTMSMLEIPADFALKQRRPDPTNNTSGKCHLLEIPAEIRNKIWEATFTGTTIKLAASTTMPGLLLTCKQINLEAQGACWRLSEFKSWNIMEIRDFLTRVGAKKLELIQHVTYDSASTLELSSRVRDVTGIAHSAFMAQWDLFWMEDWLRGEGWIWPPHLKLKAPFMAADGELVTCDSPWQTFGRRLGQESAFSLATGASREVGQLCLHTRSSLVQTVAAQSRFFGYEHQDWARCWSTKWCVVPGYQCGCPARVGRYGGGRHGARERLDAEFIPELSKADGLIGACNARRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF53</accession>
    <name>N1PF53_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prenylcysteine lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_56451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF53"/>
    <dbReference type="STRING" id="675120.N1PF53"/>
    <dbReference type="eggNOG" id="ENOG502QSHJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021176_0_0_1"/>
    <dbReference type="OMA" id="SIGIWDG"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Prenylcysteine lyase" evidence="8">
        <location>
            <begin position="150"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME40200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="528" mass="57303" checksum="B5F4E6BA3B27B594" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF61</accession>
    <name>N1PF61_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_26433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF61"/>
    <dbReference type="STRING" id="675120.N1PF61"/>
    <dbReference type="eggNOG" id="ENOG502S47Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_863369_0_0_1"/>
    <dbReference type="OrthoDB" id="2980193at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME41243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="322" mass="35273" checksum="7E13CBC3E151FB97" modified="2013-06-26" version="1">MGYWRAAADPNPRPLRDLIQMDVRQQAAATAITERPPRAPALDEPVITEYGAWVETPSLCAIRHHNVGNVRLLLEAGASPDGVAVVDMLRYTIRMLDSFRVVGDGGSMVIDTDEKELCALLRTSLSQESDVFRELQERRDASVAVPFWNCANNLHVQVVLDADSTGTPSPDTGNSPVPSLIVAAWHNLHEVVDLLLQYGADASSWTNDQGQDILLRNSTSSALSSVTPLHAAAHRGHAGMVEQLLSLGFSPNITTTKCFADATTVLQYSLVTKTFTAPLASICFVQILAQISPFEHHVWMCLFSILLWLRSTRTWSTDLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFW5</accession>
    <name>N1PFW5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_157204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFW5"/>
    <dbReference type="STRING" id="675120.N1PFW5"/>
    <dbReference type="eggNOG" id="KOG4089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086423_2_0_1"/>
    <dbReference type="OMA" id="LPPNEAC"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME40475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="184" mass="21814" checksum="BC4D7C748F5B67C2" modified="2013-06-26" version="1">MAKAATKLLPSFRVGEKELFLPSATLTFHRTTNPYNAKFRVPLTFSKLDLRDYLWHAYNVEILSVRSYVKQQRVRSGRERDIRPAMRRWHRPRSQKFMTVELARPFVWPEEPSDLKEWNRDEVEKSDKEQEEFGKKLGSTRDTEVNEERRVRMREQARELLEGKSRWRSGLARGQGAGTFVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG84</accession>
    <name>N1PG84_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_90421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG84"/>
    <dbReference type="STRING" id="675120.N1PG84"/>
    <dbReference type="HOGENOM" id="CLU_1366232_0_0_1"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="152"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME41623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="200" mass="22367" checksum="30E847EA69A0E7A4" modified="2013-06-26" version="1">MRGLPLRRDNINNLHVWTPLFATPYLGYPLRYAEGDDFRMICPGAFDAPDNEVLRLLSLDIDPYSANLGRSHVTSRTGLNLSRADGQSLEAEDAKAMEAFIRLELAHVRAQVISRTGGEYATARQQAVAAATQATPAVFEEFRKQYVRGPVCQACGTPKRWRETELASCSKCKATNYCSEECQTKDWKNHKVSKEHKGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG86</accession>
    <name>N1PG86_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_91513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG86"/>
    <dbReference type="STRING" id="675120.N1PG86"/>
    <dbReference type="eggNOG" id="ENOG502SJ54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007901_1_0_1"/>
    <dbReference type="OMA" id="PHAVRIY"/>
    <dbReference type="OrthoDB" id="5323870at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="66053" checksum="45B765CF80461499" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG96</accession>
    <name>N1PG96_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_159128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG96"/>
    <dbReference type="STRING" id="675120.N1PG96"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_17_0_1"/>
    <dbReference type="OMA" id="MILTERW"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="246" mass="26444" checksum="FFF82BC00FC87AC8" modified="2013-06-26" version="1">MPHKPLAIIAGVGSGLGSSLARRFSKSYIVILLARTEKSFGPVVDEIKQAGGEAVGVSTDISNPESVKDSFKTIGEQYAGSPVAVAIFNASGGFVRKSLLDVTVEEMEKSVGVSIRGAMLFAQSAIPLLLKYEESSPTTPPSLFFTGSTAAIKPNPLSLVMTVPRHGLRALSMSAAKEFGPKGIHVVHSIVDGAIDTPWGESFLKNVPESQKIDPAAIAEMYWDCHLQSRRGWSNEVDCRAWEEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGM9</accession>
    <name>N1PGM9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_82140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGM9"/>
    <dbReference type="STRING" id="675120.N1PGM9"/>
    <dbReference type="eggNOG" id="ENOG502SEZA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_544033_0_0_1"/>
    <dbReference type="OMA" id="DGAIWPK"/>
    <dbReference type="OrthoDB" id="5431222at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="501" mass="55382" checksum="AD8A9F165DCBC06F" modified="2013-06-26" version="1">MYAQAQPHLPPPPSVFHQSGAPPAKKSRGNGPVITRYGPPPPGYRPPVQVPVGHFGQRPAYAYHQPAYPGYQTQYQPQQLQSCLPQQLPLGTYFPQPQPTWPTIVTPPQSAPTGAWHQRSASEGLARHNSAPYHARLVLDGNGDPMPPADMTPGTGNDLEEDFDAECYFARHPEDIDSHLSLGVIEWKPPLPTKRALASTFQEAELEALAPRPLQASEDESVSEYFTKAKREESRLSVRQTDVWQEIKDSLIFREFAAVCSRIISLSEMLDQYKNRYDATWAEGDHRSPTPCLTRESTPANDGGMDIDAQGPQPLMSSNDTVLDNFERGLRARSREPSQQPRQHSRTNSVCSTASRHNAKIKRPIPLPPIHDPTQEDILAALGVTGSPKLVYQTPGPAYGPGATSAKRPHSRASSVDSVNVRWQPPIQPPLKTNGHGEDDYGYGAEPDDQVTPRPKLNRFDSSRKRSYADSIAGAIEECDEEDEEATPKQRKKQARVDGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGS5</accession>
    <name>N1PGS5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_37138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGS5"/>
    <dbReference type="HOGENOM" id="CLU_1384142_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="197" mass="22182" checksum="E21B7A095BBB83A6" modified="2013-06-26" version="1">MVCPTSLNCVHPVRDGHDLLVERNDTIGVLLAEVHDLLLIGPSWTVAKTSMFSAVNIARISSQDGKVFWSSESSTKRLKSTRVAQRIGSLHWTARRQTLHVQEVFSLVAHDALLVLVRDVVRAHVEDERIGGPVPAELGCTNQRLPHELARTRCTIETLSLSPAAECRLRCWYIARTTLSQSEESNSVPIWRRRRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH53</accession>
    <name>N1PH53_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_27482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH53"/>
    <dbReference type="STRING" id="675120.N1PH53"/>
    <dbReference type="HOGENOM" id="CLU_871616_0_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME40880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35453" checksum="5E826B89FCA57E90" modified="2013-06-26" version="1">MARKGTLVLRIAWACRPNNESVALAATVFVFLGVLIIYSNSAIHGLMAQGKGVEEVMIGMYLPLQNAWMQFSFPMFKIAEWLTPVFPRLSETFRVEWRCANLWEATGKQKIFASESKYELDGGLKLREYGIAKDIQTFLGAGGEPIGATVVYLIYAVLQDSTLRKEIKAEVAALEEPLLDTDVEEKCSILDGTTYESLRLYGGGLTCLPRYAPTAQQLGLFDQRRRMKPGQSKALQTDALQPFSSGARGCIAIHLVMTELRLFCATLFRELPGLSLGNSVTMKSMRISDRFHIAPVSKHLEVVLPRDILEEIRGVSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHI7</accession>
    <name>N1PHI7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHI7"/>
    <dbReference type="eggNOG" id="ENOG502RP5T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_746016_0_0_1"/>
    <dbReference type="OMA" id="PEKHCIT"/>
    <dbReference type="OrthoDB" id="3648880at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="371" mass="40571" checksum="9F9659822FA9D5A8" modified="2013-06-26" version="1">MAVPAVVLPPLPRAASGRSSTFRHCVQWSSEYNAPTIRTVDSLRLNVHDTTTIIVPSERRQPGSTTSRSHHLLSPFLPFFHIHARSCICRSFATNTDCITTASMHFITSVLAVAGVTAAMPGNPSYQPPSGQPPNAYSPPEKHCITSSTCSAAYHTTTKWVPYEKTKTITLTSYTPKAYTTNVEKNYTETKYVPTYYNITKTVPVTKTYTIPYSTYTTICTTKPVLFNKTSIAYTNSLSICPESDNIPKTVVKYTYANSVYTTKAACPYTTTAIRTFSTESVCTETSTVCKPYETCDSGNGGYGYGYAPPKKTDEYAAPPPKKTDEYAAPPPKKTDEYAAPPPKKTVEYAAPPPKETGGWTSYGKPAGGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHN1</accession>
    <name>N1PHN1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_74554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHN1"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_1"/>
    <dbReference type="OMA" id="REWHRML"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME41055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="273" mass="29473" checksum="E270287E7CF80FC3" modified="2013-06-26" version="1">MSSGKKVVFITGANTGLGLESVKALLKSSTEYEIVVGSRKIENGDNAIKELKKEIPNAKSSLSVVQVDIESDESIQKARDSIDSQFGRLDVLVNNAGGNFEPEVQNGKLSYREGWNKSWNVNVAGTMVLTSELVPLLLKSSDPRLLFITSGTAPLSEHDKADTPPTKAINGSPAAGWPKVKLMNPITMYRSSKTGMNMAVREWHRILKNDGVKVWAVSPGFLATGISGIGAEQLKKIGAQDPAVGGEFIRDVIQGERDADVGKAIRKDSIQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHP1</accession>
    <name>N1PHP1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_157762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHP1"/>
    <dbReference type="HOGENOM" id="CLU_1514072_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="178" mass="19223" checksum="681F2029B5DF7448" modified="2013-06-26" version="1" fragment="single">MYGGQSIAKSNHAQVLHQVDSRPPSRKSATLQPQHKVFVLPKGMCFPRTPKSQSSSSLDPADCVLLRNAKTKSQPLLPVLSAQYALLPLLKSPLLAQAMASRVSMFKKKTWRNVIQLTSSTLSTTLSAMLSGVVAEPLSDHLIRSNDFCLTTTTILEARAGEATHGGVIVEPLFSGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHT4</accession>
    <name>N1PHT4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_178127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PHT4"/>
    <dbReference type="eggNOG" id="KOG0928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001204_3_1_1"/>
    <dbReference type="OMA" id="CRDIRHH"/>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="638"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1569"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1569"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1589"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1599"/>
            <end position="1610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1610" mass="178018" checksum="9DA30B1BF75A2ADC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI38</accession>
    <name>N1PI38_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PI38"/>
    <dbReference type="eggNOG" id="ENOG502SPW3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132241_0_0_1"/>
    <dbReference type="OMA" id="HMILGSY"/>
    <dbReference type="OrthoDB" id="3913028at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="179" mass="20064" checksum="C875915ACADD2F20" modified="2013-06-26" version="1">MAATKAEPGAHKVDTGLTDSTHGSSSSSASAERYRLDEFDESPILLYKYRGGLQTSSQKDLCSWLDKDEKLRVTKKQIPRMSSYVDVKRHDLYLPDEQEMYRSLPNYDSSLASIKLPSTAYWSRLFLGNYDNLYIVSPETTPTSSVADEDSQRTSPTSTWGQGSEEFAAMGATEEHRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIB0</accession>
    <name>N1PIB0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_73619</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIB0"/>
    <dbReference type="STRING" id="675120.N1PIB0"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_88_1_1"/>
    <dbReference type="OMA" id="QPYQDPL"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14212">
        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000380">
        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="391"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="732"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="787"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="891"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME41265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="961" mass="107346" checksum="48911F3238188868" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIM7</accession>
    <name>N1PIM7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_73138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIM7"/>
    <dbReference type="STRING" id="675120.N1PIM7"/>
    <dbReference type="eggNOG" id="ENOG502QVHF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019468_0_0_1"/>
    <dbReference type="OMA" id="DLRWTEP"/>
    <dbReference type="OrthoDB" id="2150628at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051667">
        <property type="entry name" value="Archaeal_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096">
        <property type="entry name" value="YALI0E33429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase" evidence="2">
        <location>
            <begin position="90"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="523" mass="59869" checksum="C7A655FBA1B5EAC9" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIW4</accession>
    <name>N1PIW4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_73608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIW4"/>
    <dbReference type="eggNOG" id="KOG3947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_3_1_1"/>
    <dbReference type="OMA" id="PHHDAWS"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF18">
        <property type="entry name" value="ESTER HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="161"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME41246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="427" mass="47428" checksum="0EC337FD28E6F6B8" modified="2013-06-26" version="1">MFDVNVTVVVTVNQVADHLDRRQGHPRKSAIPAFNRPLRQSGRGGSQRGYASTTLDFANGRKIRGLASGPGQTISFGLGTFASHLLAGLFGFLATSIISLFPPSKGPFGIPPWWLQLLHPIKLLARTLDLIISFFRLDNTVKKNISVACISDTHSLTTGNIPQADVLVHAGDLTNAGTRFEIQQQIDWLSSLPHAHKIVIAGNHDTWLDPSSRQTLALEDQHGRLDWKDLIYLHDSSTTLDFSHRTSINEGHIKIFGMPHTPDILGPEHAFQYHRDTDFWTNKIPHDADIVVTHTPPRYHLDLPGVQSMGDEFLLREIARVKPRLHVFGHIHAGKSDIFGQARGGQEVVRWDDAEKHLEGAVQSGHPHGIFSNTVAMFHVWLLFFSGIVGAVRDWLGYEVKSTRMVNAAMVYCNTGKIGNDAQVVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJA2</accession>
    <name>N1PJA2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_90263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">NZE10</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <title>The Genomes of the Fungal Plant Pathogens Cladosporium fulvum and Dothistroma septosporum Reveal Adaptation to Different Hosts and Lifestyles but also Signatures of Common Ancestry.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Okmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H.A."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">NZE10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJA2"/>
    <dbReference type="HOGENOM" id="CLU_1013928_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30941" checksum="9991F7A5D01D428F" modified="2013-06-26" version="1" fragment="single">MEPRMAEDDRREQLKRFLADSLPNGHSVFTVAIKEGHAGTVATIIEFCRVHLSSIDCLTRSGTIKKALLSAAATAPYMETVKILLKNGFNIASAQLFGSWSMEKDLVGLLEILLLEASIEERDVFPEWVVRNVVLRSPKESCALFVSYWQRQNRPFCPHLFSQSNGPSGLLHQAVVSRKHEVVEAILQHFPSLAATTDEHDRYPLYYVFRAESGRCIPDPEANSRDALVAALITEKTALQVDDIARQSQTQLHEFVLDLSRFDSTNMDFRSFVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJB4</accession>
    <name>N1PJB4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_64311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJB4"/>
    <dbReference type="STRING" id="675120.N1PJB4"/>
    <dbReference type="eggNOG" id="KOG0005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_6_4_1"/>
    <dbReference type="OMA" id="YAGKQMA"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="77" mass="8639" checksum="916F84C47F69C3AB" modified="2013-06-26" version="1">MQIKVRTLTGKEIELDIEPEYKVQKIKERVEEKEGIPPVQQRLIYGGKQMADDKTAAEYNLEGGATLHLVLALRGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKA4</accession>
    <name>N1PKA4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_55453</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PKA4"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_0_1"/>
    <dbReference type="OMA" id="YFVAYAT"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="732"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="778"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="849"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="958"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="107"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="418"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="736"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1081"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME41701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1324" mass="143212" checksum="85B40DE80D0617D3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKG3</accession>
    <name>N1PKG3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_134265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKG3"/>
    <dbReference type="HOGENOM" id="CLU_2073094_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="118" mass="13597" checksum="4C2D427B03BC1981" modified="2013-06-26" version="1">MAKTECSQESSRRTETAQKRRPTPVSEKMFLSIAGLNPDSEQEHRLYLLMKIEALHAVQDLNSRPVEESRLRQAMSMLYQSASPETRRVYNLYGDAVSASPGDNWIIRWLMWQALAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PL98</accession>
    <name>N1PL98_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_36216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PL98"/>
    <dbReference type="eggNOG" id="ENOG502TBAK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_706016_0_0_1"/>
    <dbReference type="OMA" id="CTCIESA"/>
    <dbReference type="OrthoDB" id="3637543at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="391" mass="44314" checksum="62BC72C40B4CB0F8" modified="2013-06-26" version="1">MMYSRCTDDELRQFVKDRRLAVKIARPDSATPNREDYIEALKRADNHLTKPFSFFEIPAELRNRVYELLVDDESLASAYPRLLGSSGQIYDEASNMLYSSNAVTMKIGSSIVHVNGRRVRNHSSRSIATLYMKWPAVLKKVAHFRIAFTGTWQSQLTGGVTPSLQSSWKNKHRERASAVNQVLFSLALFLLPKNNLKNVTLDLASMLGKAPDLRPYEKCTCIESAFRPLRFFPQLAGNHIELDRMAHAEFTELIESLWSEPTWLPSHNVPLHDLSPIMLKAEACHRLCSKLDLYDEEGDNRWKFMGSNSWVDRELTTGGIERRLSEAKSRLNPGKSVSRENEAPLLLAIAAPKGHIEKLDIDGIRAQAGESAMAMMKRDLDKMENVIKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLR5</accession>
    <name>N1PLR5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLR5"/>
    <dbReference type="HOGENOM" id="CLU_3032313_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="55" mass="6308" checksum="7C8499852981F95D" modified="2013-06-26" version="1">METVPQSCWNPAVGNSTSQNHFAKLVQQRRTPTRLAGCPWRIRQQHSGSNHPRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM22</accession>
    <name>N1PM22_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM22"/>
    <dbReference type="eggNOG" id="ENOG502R98N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1107106_0_0_1"/>
    <dbReference type="OMA" id="WPKLNIT"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="251" mass="27447" checksum="ADD90D67B02F8FFE" modified="2013-06-26" version="1">MVLKMASKDPVVTALEPARKILLQQVLNEQGHALNFNGESTILTSSSQTAETLAEWLWEKKLDMPRSIIVSGETSEQDLSPELQRGANIQIVSQVQDASSTHAFSHVDVYSQRGTSELLAGIHHGLVPNGTAVVTCMKRNPVEVIMKSVFSATGRRSFVGGRESAMEGELKALAVQAGFEEERVRILQENVLVGGSPLQKLKDDVERTLDGALGNAGDGHSWESTLDRMWNREVAKYGGVLIESWLLVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMD9</accession>
    <name>N1PMD9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMD9"/>
    <dbReference type="STRING" id="675120.N1PMD9"/>
    <dbReference type="eggNOG" id="ENOG502SD5D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109896_1_2_1"/>
    <dbReference type="OMA" id="HIPRYFA"/>
    <dbReference type="OrthoDB" id="2122308at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="14990" checksum="0FE7DD8051F8251C" modified="2013-06-26" version="1">MTRTHKGNDRDHVGLANGTAAPEEHLPRYFAKSGFDGIAPTSVKKQGSGKGNWGQAGVSELEDYDFPMTRPKRRSNSSSAAAGHSALKTKFEDLDADAIVEYDEDLHGPSADDQLEKMSTSSSADTMASVEEEDVKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMG8</accession>
    <name>N1PMG8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMG8"/>
    <dbReference type="HOGENOM" id="CLU_1627000_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="163" mass="17930" checksum="1999F6392E605187" modified="2013-06-26" version="1">MRPLSGHAPSPSRRREQANRTVARISCGSGAARRDRTISNSGHTFKAAGKLHAQNGWRLPAQHVWWSPCSFPYAHGSRVTGHNVCSTDIRACCGYVVLRTCTLAVAQTHKAPKDVMVAQSPYSDNVHVTVSDQQTPTFEYRRQKCTLSLAASVSRPTRSPGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN71</accession>
    <name>N1PN71_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_34435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN71"/>
    <dbReference type="HOGENOM" id="CLU_1510573_0_0_1"/>
    <dbReference type="OrthoDB" id="3636858at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="178" mass="19764" checksum="3B24C4572690214C" modified="2013-06-26" version="1">MLSLCYNNCDLSTESTDCSMSYTDNLQSHAALSGLGKLHITSPATPVNPLNRCLPFEVPAELRNSIYENVLRRGPPRINLDLSHAFNPTVQAGLYTFSIAMTCRRIHNECAKVLYTVNRVIIHAPVFGAHQSDPMTVGATYKDEIAARLRTIAQRQISLQQFQDVKIHLGTLPSLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNA5</accession>
    <name>N1PNA5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_149564</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNA5"/>
    <dbReference type="STRING" id="675120.N1PNA5"/>
    <dbReference type="eggNOG" id="KOG3457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133423_0_1_1"/>
    <dbReference type="OMA" id="SSGMWRF"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME44882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="11511" checksum="4F162E65BE79F9E7" modified="2013-06-26" version="1">MSSPRPSSPVNSNPTTGTTTARPASPKAPGGPATAIRRKAAADRADKVANARPSSTRAAGAGGSSSTMLRLYTDESPGLKVDPFVVMVLSIGFIISVVALHIIAKFTKRFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNU2</accession>
    <name>N1PNU2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_24190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNU2"/>
    <dbReference type="STRING" id="675120.N1PNU2"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_8_1_1"/>
    <dbReference type="OMA" id="TRGESMF"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="580"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="736"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="743"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME44094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="830" mass="91055" checksum="55D4D33A14695446" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNY5</accession>
    <name>N1PNY5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_151864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNY5"/>
    <dbReference type="STRING" id="675120.N1PNY5"/>
    <dbReference type="eggNOG" id="ENOG502S2ZP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051199_2_0_1"/>
    <dbReference type="OMA" id="HVECMNR"/>
    <dbReference type="OrthoDB" id="18530at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368:SF1">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109496" evidence="2">
        <location>
            <begin position="24"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="304" mass="32722" checksum="47F61A201BA6DC68" modified="2013-06-26" version="1">MSSSRVPLVIRLFVAFYTALAAAAQQEVLSSAKAETPGYKVGQPIPVSCLNRTIDTGEHITDASGQLSYIPAFTCNETGRPLELYFGIEKDINCTIDFIDDPFFHLLEFYVHNDAPLTCRIPTKPLPPAVLKEEFEAGTKDMTDGQGSLSEIYTPLIIALTGTLQLSHLHVSTAMNVLVHAVPKSIAPGTIAAATAYSISREPPSRIVIGDPLPLRFSVRWYPNTALPSGWTGIGGHLTFSTFVYCLISALASAAICVAYFRGVELPRRLKSHGKDRLSGMERGGLGGYGLGANGYGYGPGKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPP7</accession>
    <name>N1PPP7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_33877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPP7"/>
    <dbReference type="HOGENOM" id="CLU_1677849_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="157" mass="17002" checksum="A3DC8B4E5C63B74D" modified="2013-06-26" version="1">MPQMGTMNSRFTIHDSRSTIHRDWKGFPSTTVLSECRCAYASGVATVHIGAGSFTAAASCALRRTNDSAAREALLGGLRRTAFPLDLPFCRDPGFYTGRVPPSSTMLDGQSMPGVYTTHTESTSYIGMTVVLKPHSYVGMVSVAIGLLPRDLDARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR74</accession>
    <name>N1PR74_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cercosporin MFS transporter CTB4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cercosporin toxin biosynthesis cluster protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_78389</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">MFS transporter; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin. The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl radical, superoxide, hydrogen peroxide or singlet oxygen upon reaction with oxygen molecules. These reactive oxygen species cause damage to various cellular components including lipids, proteins and nucleic acids. Responsible for secretion and accumulation of cercosporin, but does not play any roles in self-protection against the toxicity of cercosporin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR74"/>
    <dbReference type="STRING" id="675120.N1PR74"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_1_1"/>
    <dbReference type="OMA" id="APEMRLW"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="254"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME45946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="714" mass="78700" checksum="B61EF1B09EA9708E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRU2</accession>
    <name>N1PRU2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_22212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRU2"/>
    <dbReference type="HOGENOM" id="CLU_2512607_0_0_1"/>
    <dbReference type="OrthoDB" id="3934270at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9688" checksum="7EF8065031D290C6" modified="2013-06-26" version="1">MAHKRRNLSIDAAGPQCKKQKTSPTFTPSEKKKTPSSLLTLPAEIRNNVYEYALYEDPNIWITSDIREPPLLSVNRQIRHEALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRX3</accession>
    <name>N1PRX3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_125661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRX3"/>
    <dbReference type="HOGENOM" id="CLU_3019828_0_0_1"/>
    <dbReference type="OrthoDB" id="2123594at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="56" mass="6016" checksum="40F963024AFC91EB" modified="2013-06-26" version="1" fragment="single">SLDRSGFPAAISVAEAADFVVVVIFTLPPDQSQLWQGLDVTTNEHVDLSSPRGSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS38</accession>
    <name>N1PS38_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_148348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS38"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_3_1"/>
    <dbReference type="OMA" id="LSECFCN"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME46276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="68039" checksum="DDE73999A18BFD70" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS52</accession>
    <name>N1PS52_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS52"/>
    <dbReference type="HOGENOM" id="CLU_1713205_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="153" mass="16078" checksum="6248BFB754004924" modified="2013-06-26" version="1">MDGELRSNPRAKTRVIEGQTSISKTSLTNPIAGEPSVRQNVDTTSCHAGTMSTANSALLQKTESQPNIVAKRPFEDHSARRLPAELDDAPAGQVTDAVVAISGQESQAWVSSAPTTTAQLATMSTRNGSRLRTVDCTSGRSLSASPDRAILGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSJ9</accession>
    <name>N1PSJ9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DOTSEDRAFT_70378</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSJ9"/>
    <dbReference type="STRING" id="675120.N1PSJ9"/>
    <dbReference type="eggNOG" id="KOG0419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_2_1"/>
    <dbReference type="OMA" id="DHKSQYI"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990305">
        <property type="term" value="C:RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990303">
        <property type="term" value="C:UBR1-RAD6 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034620">
        <property type="term" value="P:cellular response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007535">
        <property type="term" value="P:donor selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042275">
        <property type="term" value="P:error-free postreplication DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000639">
        <property type="term" value="P:negative regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090089">
        <property type="term" value="P:regulation of dipeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120174">
        <property type="term" value="P:stress-induced homeostatically regulated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="22">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="20">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EME46357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="151" mass="17171" checksum="CBA888333CEA3B6D" modified="2013-06-26" version="1">MSTAARRRLMRDFKRMQTDPPAGVSASPIADNVMTWNAVIIGPSDTPFEDGTFRLVMHFEEQYPNKPPGVKFISQMFHPNVYGTGELCLDILQNRWSPTYDVAAILTSIQSLLNDPNTSSPANVEASNLYKDNRKEYTKRVRETVEKSWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSK3</accession>
    <name>N1PSK3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_42948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSK3"/>
    <dbReference type="STRING" id="675120.N1PSK3"/>
    <dbReference type="eggNOG" id="ENOG502QQNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015737_0_0_1"/>
    <dbReference type="OMA" id="WGDYKGT"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="142"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME46431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="345" mass="38713" checksum="98FCAABEB4661A0E" modified="2013-06-26" version="1">MLILHRNWFMRALPLHLARIGHRTARQRTFAGATYNSPNHSPQAQQNAHADEQKANDPRLKNVDDLIEDKFAVLKSSYDAPKYPIILAHGLLGFDQIRPAGRFLPGVEYWYGITQALAAKGVEVVTAVVPPSGSIEARAAKLAEAIERKANGKAVNIIAHSMVGLDSRYMISRLHPPNVKVLSLTTIATPHRGSAFADYLFQQIGMTNIPKIYKVLDFFGIETGAFEQLTRDYMAESFNPRTPDVDGVQYYSYGAAFEPHLTSVFRKSHDVIQKVEGANDGMVSVESSRWGEYKGTLNHVSHLDLINWTNRLRWWFWQVTGAKKKNFNAIAFYLSIADMLAKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSQ2</accession>
    <name>N1PSQ2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aquaporin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_170860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSQ2"/>
    <dbReference type="STRING" id="675120.N1PSQ2"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_1_4_1"/>
    <dbReference type="OMA" id="RAFLYWI"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF283">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME45449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="29771" checksum="5CF7F4F8D88DA907" modified="2013-06-26" version="1">MNKSAKAHFVATIGEFMGTTMFLFFAFAGTQVANIGAGSRTDQSTTNASTGFSPIVLLYIALSFGFSLMVNVWIFFRISGGLFNPAVTVAMVMVKGVSVVRGFLLIGAQLVGAIFSSFLVSVLFPTTFNVRTTLSEGTSIARGVFIEAVLTGELVFTIYMLANEKHKATFMAPIGIGMALFVAEMVGVYYTGGSLNPARSFGPCVISGVWDQEHWIYWVGPTLGAILAWGFYRFIKMLEYEMANPGQEASSSEEAAFEAEELTPQKPGSREKQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSQ3</accession>
    <name>N1PSQ3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_51568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSQ3"/>
    <dbReference type="STRING" id="675120.N1PSQ3"/>
    <dbReference type="MEROPS" id="S10.016"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_3_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF131">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012384356" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="16"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME45963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="62637" checksum="87BC80672D508D90" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSR3</accession>
    <name>N1PSR3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_33959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSR3"/>
    <dbReference type="HOGENOM" id="CLU_1758765_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110105" evidence="1">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="148" mass="16155" checksum="54108474B7387D9D" modified="2013-06-26" version="1">MQHSLYHVLYQLLAAMVLTQISMACPGLAGTCESGGECDVPRVGWKCAAQGPRARGNDLDMPPLDHEMQGQDINDMQKCERRDSESKDASLWKDTPSTSLVCKQMMKHIKGGPIRPHAHESVSLARSIIVFLAAAVVRRTEDAVLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT94</accession>
    <name>N1PT94_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DOTSEDRAFT_87114</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT94"/>
    <dbReference type="STRING" id="675120.N1PT94"/>
    <dbReference type="eggNOG" id="KOG2448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_1_1"/>
    <dbReference type="OMA" id="LAWQFNT"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF13">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="18">
        <location>
            <begin position="68"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="19">
        <location>
            <begin position="407"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EME46592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="602" mass="65195" checksum="BF1E5712AD696647" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTD6</accession>
    <name>N1PTD6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTD6"/>
    <dbReference type="HOGENOM" id="CLU_1758762_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="148" mass="16713" checksum="79BC48B7D90FD610" modified="2013-06-26" version="1">MCPHGISVLRTPARVAARFPEANRAPHLSQIRSRHIILASRLEQSFRIFCSMPVCTTFSGATCHTPKAVQYRASYVSPGRDRTCTPPIVPTLANILIPAAHLQGDWPWWTTYKLSHLAFNSSRNRLAATLLVVKRDRLRRITLQPARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU77</accession>
    <name>N1PU77_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_70486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU77"/>
    <dbReference type="STRING" id="675120.N1PU77"/>
    <dbReference type="eggNOG" id="ENOG502S5CN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061230_3_0_1"/>
    <dbReference type="OMA" id="EGEWALY"/>
    <dbReference type="OrthoDB" id="3928002at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF1">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110175" evidence="2">
        <location>
            <begin position="19"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="278" mass="30732" checksum="60336FD9D9D0F3E5" modified="2013-06-26" version="1">MDVILGLGIALPVVTTTAISVTTGVAQGVQEQHKQNADASNQTRMLKFHLDVWIDSAHRKGPGASLHGGIVTIRDSKVWVEPKNSTTNLPEHMAKGSHPFTGFYLAYPDDNRSYTRGIVTTISVDPPMLNWMYVDKDTYECKCATRSGSIMHHVGDYDWTTDSNDDSMVTFDEFEGFVAIQERDDGNEMGWALYFDMDDDGLKKMRKGRKAVEVHLQRRVIMGQEVNKWGLKEEGNMGFKATEEVNKLRKGKKEQKEQGTQAENGSAGGGGEGGQVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU78</accession>
    <name>N1PU78_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_22944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU78"/>
    <dbReference type="STRING" id="675120.N1PU78"/>
    <dbReference type="HOGENOM" id="CLU_1224746_0_0_1"/>
    <dbReference type="OrthoDB" id="3692311at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="226" mass="25097" checksum="27BD56003E7000C9" modified="2013-06-26" version="1">MTFSGLEWATGSSSEISLFFDLLITTPSAESLFPGFFENSDKSCDMIEDGNLDIASTGPHMFRLAQLLNTFWLSWVYPEAMTGAFDSTMKSESQMQSPVGIHQPTSTTADVETIHIVLQVQWPWAAILTATLLLLIAAGLTTAFLELNRHAPMVLDTSMSSLKQNSYAKFNRGNCTEDGADMARRLKYLQVQIGDVRPWGGVGHVAIATPWMVQEVKEIKEHRLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV20</accession>
    <name>N1PV20_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_52171</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV20"/>
    <dbReference type="STRING" id="675120.N1PV20"/>
    <dbReference type="MEROPS" id="M16.003"/>
    <dbReference type="eggNOG" id="KOG0960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_4_2_1"/>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017087">
        <property type="term" value="C:mitochondrial processing peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="53"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="205"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME46793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="481" mass="53506" checksum="D1D01C10F4F170B5" modified="2013-06-26" version="1">MASRRLALSLQQGLRAQRAINAVKPNITRRALATPVSHASTTESTTLSNGFTIATEHSPFAQTSTVGVWIDAGSRAETDKTNGTAHFLEHLAFKGTQRRSQSQLELEIENMGGHLNAYTSRENTVYYAKSFNSDVPNTVDILADILQNSKLENTAIERERDVILREQEEVDKQLEEVVFDHLHATAFQNQALGRTILGPKENIQSISRNDLENYIKTNYTADRMVLVGAGGVPHDQLVQLAEKYFSKIPAYNPNAQDNAYVRGLDSKPDFVGSEVRIRDDTMPTANIAIAVEGVSWKDDDYFTALVTQAIVGNWDRSMGNSPYLGSKLSTFIHDHKLANSFMSFSTSYSDTGLWGIYLVTDAVTRIDDLVHFTLREWSRLSFNVTEAEVERAKQQLKASILLSLDGTTSVAEDIGRQIITTGRRLAPEEVERVVGAISAQDVMSFAQRKLWDRDIAVSAVGQIEGLLDYARIRNDMSRNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV22</accession>
    <name>N1PV22_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_98485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV22"/>
    <dbReference type="STRING" id="675120.N1PV22"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2596685_0_0_1"/>
    <dbReference type="OMA" id="SSMWIIN"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME46200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="80" mass="9377" checksum="A115CD118EA2D51F" modified="2013-06-26" version="1" fragment="single">EDLKKPSMTYIYIIDEILSSIEGGQADLQTIYDKIQKRWPYYKYRVGSIGWQSSVRHNLLSCERFVDAGKSGKGKFWRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV37</accession>
    <name>N1PV37_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_51754</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV37"/>
    <dbReference type="STRING" id="675120.N1PV37"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_4_3_1"/>
    <dbReference type="OMA" id="TVSCFGW"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="14">
        <location>
            <begin position="44"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="261"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME46215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="56628" checksum="50F8896F122F961A" modified="2013-06-26" version="1">MAQPFHVGGAANVLSAPHSFELLRRSMLDRLHELDFTHLGSIVAIAGIIPAAWRGFHHAWREAATAVKRFFIASVTMPPGDPLNRSVSSWILENVIEPRNLRFQTARTEVGHDLEPGSSLKKTPRSVQYFPHWQSAWFWHESKLLAASRSLESFQAGMKDPTYDGIGGEELTISCLGLSAEPIRHFINQCRDIADSKAQFYVIIYSRDRYGLSWKPKYRKPLRRLETVHFDDSIKQNLLADIRTYLDPRTKKLYQSRSMPYRRGYLFYGPPGTGKSSLSTALAGEFGLDLYEVKVPSIANDGELEQMFQEIPPRCIVLLEDIDAVWVSREQRLEQRPIFDGASERSATPSTSNVSLSGLLNVLDGVGSREGRLVIMTTNKPDQLDSALTRPGRIDFKLYLGNISRRSAEQMFMRMFAPDLLSWARKSSEKTGSLDEHVSVEQLRMLAAKFAEEIPGDTFTPSQLQGFFQLHLNDVMQAVSSIASWVKHELALRSEKGFEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVT1</accession>
    <name>N1PVT1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allergen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_41561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVT1"/>
    <dbReference type="STRING" id="675120.N1PVT1"/>
    <dbReference type="eggNOG" id="ENOG502TC4P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096540_0_0_1"/>
    <dbReference type="OMA" id="VKSHEHE"/>
    <dbReference type="OrthoDB" id="2118965at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25669" checksum="885FFDDC6373960D" modified="2013-06-26" version="1">MDAATSAVSKLLYGKSGEKAEATPPPPAASNDDVPDRANDTDSSGAGQKDTTIEQEVAPAVEHETVKKEHETREQTVIDRERHQHHYHTTVQPLKDREVEATEHVHEQAATQERVIDKDDEGDQIKARVDAREGAFSDKTVEAATKETKTDEGEVVGEQVHHHLHETIQPVIEKETIVPSVTHKTIPVHEVINEATKDHGVTKKEAISVDEFKHNLDGEASTKIKTDGAEVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW43</accession>
    <name>N1PW43_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_77552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW43"/>
    <dbReference type="eggNOG" id="ENOG502RA09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184986_0_0_1"/>
    <dbReference type="OMA" id="HSHIGRI"/>
    <dbReference type="OrthoDB" id="3642267at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25460" checksum="AA26D576C3AF8C02" modified="2013-06-26" version="1">MSGIETTFISAQHQVLATTELFECILLHLGAQTLLLSQRVNKSFHYTIRGSCKLRQKLWLQPGDSDHDVENPLIPSIATRTRINPFLATPWVRQHCHSHIGRIEFGEPDTSGGFLAPVLRIICRKGVSFQESPRASWRDMIVVSKHEPYFQFRIMRHSPENGNLLLWQLVFFEKSPTAGELIELALEPKSLSDLVVRKDGSRVWASTVPRLRQILQELDGGAGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWA4</accession>
    <name>N1PWA4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pseudouridine synthase I TruA alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_22677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWA4"/>
    <dbReference type="STRING" id="675120.N1PWA4"/>
    <dbReference type="eggNOG" id="KOG2554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_2_3_1"/>
    <dbReference type="OMA" id="SCRERRY"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02569">
        <property type="entry name" value="PseudoU_synth_ScPus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041707">
        <property type="entry name" value="Pus3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="266"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME46630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="667" mass="74928" checksum="9CA51CF5906C3D38" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWS1</accession>
    <name>N1PWS1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_86341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWS1"/>
    <dbReference type="STRING" id="675120.N1PWS1"/>
    <dbReference type="eggNOG" id="KOG1191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_3_0_1"/>
    <dbReference type="OMA" id="VQIGFHI"/>
    <dbReference type="OrthoDB" id="188276at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116878">
        <property type="entry name" value="TrmE connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GTP-binding protein TrmE N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="MnmE helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="5">
        <location>
            <begin position="220"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME47986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="524" mass="56009" checksum="B13E54F32A489744" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX33</accession>
    <name>N1PX33_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_42274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX33"/>
    <dbReference type="HOGENOM" id="CLU_2793941_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="68" mass="7339" checksum="2DC3CFB4357B520B" modified="2013-06-26" version="1">MIRCVVGEKPKSNGRYIAAFAITTDGNAGDEGRYGWSVQSMIDVLSGGAIFVAFCSSILLLNIVRVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXF8</accession>
    <name>N1PXF8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_79009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXF8"/>
    <dbReference type="HOGENOM" id="CLU_1184984_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="24844" checksum="D75A06E31F74ACAD" modified="2013-06-26" version="1">MPRELETKSGSPKTVAIKNNGDDGDNDIDQSKGHGHGRAEDKPRNAGDAQQYTGSSGDVRPAEDPALDIDEPEKNTAEEDNAMNPEPEQPEAAGEEPAQLSQDPREPSQDAANDGAAEKLMAASSNELNGQSADEPDDEAGGPAPVESAGKSNDQPDNSSKQTSEDDSLRIPDPFVWSVAEGLARLGLGILNNPSGRQIVHRDLKPENVFLDRPSKTDTLTTPPLESVTSAKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXG1</accession>
    <name>N1PXG1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXG1"/>
    <dbReference type="STRING" id="675120.N1PXG1"/>
    <dbReference type="eggNOG" id="KOG1371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053163_2_0_1"/>
    <dbReference type="OMA" id="PDNECYA"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08946">
        <property type="entry name" value="SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF6">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="353" mass="39253" checksum="68EE9121C24D1868" modified="2013-06-26" version="1">MEHSMPAGIDLLQGTASAAGDGITSGRADVQPEHLPGSAQQPRAAGKRIVFTGGSGKAGRHVIPYLQKQGHKVLNLDLVDFPDKDAGVFTLKADLTNSGEVFNALTTHYTMAGYEQGYPEPPPDAVIHFGAFARNMIVPDNKCFADNVTSTYNVIEAACKLGVKKVVIASSETTYGVCFAEGDYDYHQFPLEEDYDVDPMDSYALSKLCGERTARTFARRYGADIYALRIGNVIEPHEYGDFEVYVNKPETRKRNAWSYIDARDLGQICDLCIKKSQLGFQVFNATNTTITTKVPTEQFLKETCPNVKITRKMDEWEAPLSNRKIREVLGFVENHNWRQYYPDSSIAQKLGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY22</accession>
    <name>N1PY22_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_21625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY22"/>
    <dbReference type="HOGENOM" id="CLU_1786799_0_0_1"/>
    <dbReference type="OMA" id="NDMDRRA"/>
    <dbReference type="OrthoDB" id="10356343at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109682" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME47893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15479" checksum="7F8F1B40D9118EE3" modified="2013-06-26" version="1">MSQTPSSNDMDRRAIALLFLLHATHTMAFESAAVNTYSATQVNTGPAPTGPKDREISHLSQGARAGIATSAIFGAIVVLAIAFFVWKRVKRARMEKASQGVYLELQSGGPNKAALSQPPSAKPAESVPDLHLPLAHMQRSEELGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY99</accession>
    <name>N1PY99_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methylitaconate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_57834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PY99"/>
    <dbReference type="STRING" id="675120.N1PY99"/>
    <dbReference type="eggNOG" id="ENOG502QSUX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026443_2_1_1"/>
    <dbReference type="OMA" id="MCHESMA"/>
    <dbReference type="OrthoDB" id="10267539at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="42470" checksum="19A4C6047E328E01" modified="2013-06-26" version="1">MQRSTVPAIYMRGGTSKALFFHDKDRDRFLMRVMGSPDPMQMDGMGGTYPVTSKVAVIRPSKRDDADVDFLFAQVSVKESFVDWDAGCGNISAGVGPFAINEGLVKEARIGNAAKGCTTQEVRIYQPLSTKKVLVAHVPIDQKTGKFVEKGEYKIAGCPGTGSPILMDYRFTIGGGVHKGLLPTGQMTNTMNIDDRPIEYTICDAAHIIAFAHAYDFGLGGNEHPKKINEDTNLLAKIRQFRGQAAHSVGMSRSPESADHDSPILPMVALLSKVPDGEEGHVQSRLFLDGACHSAMAGAGATCTAACSRLTGSVVAKVMRQEALDEKVFKVLHPSGVLPNSIEEDESDEIGLPRFKTLSFMRTARYLFKGDLFVPEDLEAKFEEGVENGHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYH7</accession>
    <name>N1PYH7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_49016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYH7"/>
    <dbReference type="HOGENOM" id="CLU_1488976_0_0_1"/>
    <dbReference type="OMA" id="FRTYTHK"/>
    <dbReference type="OrthoDB" id="10298631at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20518" checksum="781ECE69200B9A9B" modified="2013-06-26" version="1">MAHFNDLPNELLAQIISYNVPSALRSRVDFIQFMRDGASSKRFLRITKDTFFRTYTHKVDITCIYTALSPRCAYTQVHHEGTLAARRAFCNQIRDAKLRLHVYYPASIGIAVQELKGALDRYGQLRSLRVEISTGSVEVADELGEKVQEVLDVYRPGRNRLETCLTTDLMGHQVMSCSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYX7</accession>
    <name>N1PYX7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_21892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYX7"/>
    <dbReference type="HOGENOM" id="CLU_1026813_0_0_1"/>
    <dbReference type="OMA" id="YCPPAKT"/>
    <dbReference type="OrthoDB" id="10666213at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012723188" evidence="2">
        <location>
            <begin position="16"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="271" mass="29301" checksum="867EB438DAFC4475" modified="2013-06-26" version="1">MKFILAAALVGTTLALPNYESSCPQPTCPICPPEKYCPPAETKYSTTTAYSTTTAYKPGPTEYQTATITEQKNCPNKYCPPAKTETQTIPTTITESKSCPNKYCPPAKTETQTIPTTIIESKSCPDKYCPPAKTETTTIPPVTVTGPAKSPAPYCPDKPERTVTFTATAKCPAPYCPDKPKETVTTTTSQSKDCPAPYCPPKQSFTVTEKIGAYPQPEKTITITEYQAPQATVTQVKTVTATQSCKDYGGEKPKEKPKPEQPAKKPDGYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYZ6</accession>
    <name>N1PYZ6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYZ6"/>
    <dbReference type="HOGENOM" id="CLU_2904167_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="62" mass="6924" checksum="27B5CB3B8915CFB6" modified="2013-06-26" version="1">MSDGFDCGANIERFLDLARDVDCVTLDTSMREYVARHQKEGVHTAMSAVESDNMISAWQVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZL1</accession>
    <name>N1PZL1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_67480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZL1"/>
    <dbReference type="STRING" id="675120.N1PZL1"/>
    <dbReference type="eggNOG" id="KOG2423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_4_0_1"/>
    <dbReference type="OMA" id="RTQGFNH"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000200">
        <property type="term" value="P:regulation of ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="229"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="524"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="539"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME48448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="590" mass="66132" checksum="2D00C88C4082EF58" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0N3</accession>
    <name>N1Q0N3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleotide exchange factor Fes1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_69951</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FES1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0N3"/>
    <dbReference type="STRING" id="675120.N1Q0N3"/>
    <dbReference type="eggNOG" id="KOG2160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084507_0_0_1"/>
    <dbReference type="OMA" id="LKWSVEN"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000434">
        <property type="entry name" value="Hsp70 nucleotide exchange factor fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="7">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME48180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="212" mass="23395" checksum="CB216D4338929B23" modified="2013-06-26" version="1">MAGQKESLNQLLQWSTENSVNDGQKRDPTQGITQEMINELMGGPSDADRMRDAMTAIVAPTDQIDLGNKLIAWDNFEQLIENIDNANNMEPMGLWAPVIQQLDNQEPQMRRHAAACCSTAVQNNIKSQEKLLSMGAVPKLAKLAVEDSNLAVRKKAISALSSTVRNFQPGMDELEKSLPDSVWTRKQGIDAADMEACDEVIQKLRDNSTARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q125</accession>
    <name>N1Q125_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_68285</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q125"/>
    <dbReference type="STRING" id="675120.N1Q125"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_0_1"/>
    <dbReference type="OMA" id="IKGRSEM"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033833">
        <property type="term" value="F:hydroxymethylfurfural reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000947">
        <property type="term" value="P:amino acid catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033859">
        <property type="term" value="P:furaldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="35"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="209"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME49466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="386" mass="40771" checksum="F0959525A62BCA99" modified="2013-06-26" version="1">MSSTEGKTITCKAAVAWEAGKDLVIEDIEVAPPRAGEVRIEVYYTGVCHTDAYMLSGKDPEGAFPVIAGHEGAGIVESIGEGVTNVKKGDTVVALYTPECGECKFCKSGKTNLCGKIRATQGKGVMPDGTSRFKCKGKDLLHFMGCSTFSQYTVVADISVVAVTDKAPMDRTCLLGCGITTGYGAAVITAGKGGVEKGANVAVFGAGCVGLSVMQGAAARQAGKIIAVDVNDTKKEWSKKFGATDFVNPAKDLKEGESIQQRLIDMTDGGCDYTFDCTGNVSVMRAALEACHKGWGESIIIGVAAAGQEISTRPFQLVTGRVWKGCAFGGVKGRSQMGGLIDDYMSGKLKVDEFITHRQPLSKVNEAFHDMHAGDCIRCVVDMRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1J4</accession>
    <name>N1Q1J4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_67538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1J4"/>
    <dbReference type="eggNOG" id="ENOG502R9BN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173506_0_0_1"/>
    <dbReference type="OMA" id="ANTDSTM"/>
    <dbReference type="OrthoDB" id="5389892at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="94" mass="10160" checksum="F55ACEDE948A4951" modified="2013-06-26" version="1">MSTTKEDRDLKRADDYLNRTNEPEPGQVTGPGAHFNDTFDPALKKNAPASAVQQVQQSAQEKLSHTDSTMTTAQLQAAAKEGDPNGLLGKKVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1N9</accession>
    <name>N1Q1N9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_98527</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1N9"/>
    <dbReference type="STRING" id="675120.N1Q1N9"/>
    <dbReference type="eggNOG" id="KOG0570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065214_0_1_1"/>
    <dbReference type="OMA" id="MMQDHLD"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME49163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="199" mass="22515" checksum="8F55CBB840D553C7" modified="2013-06-26" version="1" fragment="single">FPAPPPFYGHFTKFNIARLRQLRREVGIPAPAPTDTILDATAANDADIDILSLPVELRYLIPPAPPSDGKYTAFGNTIDPHAAERSLAERDIEQLYPSNTSSRLNPQPHLTALTRSMLTTFLALSGILSQNPELYEEKVKDLHTIAMNIHELINQYRPHQARETLIMMMEERVDKMKKESHDVDKAKEKVAKLLQDIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q234</accession>
    <name>N1Q234_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4246 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_98584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q234"/>
    <dbReference type="STRING" id="675120.N1Q234"/>
    <dbReference type="HOGENOM" id="CLU_2711557_0_0_1"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="73" mass="7901" checksum="AFB08E9AA4A13765" modified="2013-06-26" version="1" fragment="single">NACVYVSNNAVSDGTKTTLQKAATRLADVKEYQRDWHPGSDGKMLDQVHPSLVPHVCGRSSMVPTVTVTLKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2P0</accession>
    <name>N1Q2P0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_84429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2P0"/>
    <dbReference type="STRING" id="675120.N1Q2P0"/>
    <dbReference type="eggNOG" id="KOG0529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031996_2_0_1"/>
    <dbReference type="OMA" id="RKFPKCY"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME48920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="372" mass="43498" checksum="32F3AE3C1029B578" modified="2013-06-26" version="1">MASHGVPRISGAPVDRSEAAKAKERRQIEQYKTLEREVTDKINARDYSSSTLQLASSLLSRNPEYYTIWNHRRVLLEWVFAKELANTNAQVDPKDAEAAQKAGLTIPQREILLLIKEDLQFLIPLLKQYPKCYWIWNHRRWLLTAATAYVPPRAALELWQGELGLVSKMLSLDSRNFHGWGYRREVVEHIERLGEKSMVEPEFEYTTKMIKSNLSNFSAWHNRGQLMPRLLDERNASDEQRKTLLDSEFELITEALYTDPYDQSLWFYHQFLMSTFDERNPKAPAVLANVGRADRLEYLEQELDSVREMLDGAEDCKYIYQALLEYSSRYLEVDAGNKELITLEMKSWLDAVRKLDPLRKGRWEDMASKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2P8</accession>
    <name>N1Q2P8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2P8"/>
    <dbReference type="eggNOG" id="ENOG502SZHN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794584_0_0_1"/>
    <dbReference type="OMA" id="MWGADKI"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="349" mass="39752" checksum="DC05C6B1FE155086" modified="2013-06-26" version="1">MEKLILRGVMWGADKIPDSVFEKIPGGYYKAKEEQYKREKAEEKAESRTQRHHRDNDDMPKRRSRRRYSEDDSDDRRHRAEEREDEYTSDGHGRRSDVQRHDGVGDSYDPINDRPRRRRSRADPDRGVDRSKRDTRNGEGSLNGGWSYHDGPVEPPPMSPLQAATGAAYGSPPPTQAVPNNMVAHVETASRSTSTLRGGMATGYVPYANIYGSPTQAQQYPPSDTGSVQPNHTNQVGPPVQPQQGYHQNPFAQEAPLGSQPGYVADPFYKARRYDDRHNERDQGTDGASTERGHSRSPPRRHRSRKEDYSPSRDSYSSRDTRRRARSERRHDDAPPSQARARERYVSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2U8</accession>
    <name>N1Q2U8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ATPase complex subunit ATP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_113086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2U8"/>
    <dbReference type="STRING" id="675120.N1Q2U8"/>
    <dbReference type="eggNOG" id="KOG4614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047290_2_0_1"/>
    <dbReference type="OMA" id="YFPNFHG"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="33649" checksum="256CE0CE786FAE9F" modified="2013-06-26" version="1" fragment="single">DQEFEPQPLSRPIGMPNPPQSGENIGLDERTLSQRRDDFVNYDKHLERRSKMTKQISKPYFRDWSNLRFHKGKMFKSNERLFRRDASLWFPNFYGKTLRKDDQPRRLWRGDGYKGLGRDTCEAMQGKVSVVSIVSSTWAKQQVDTFCSKEQNPELHEAIKANADVAQQVEINYENNVLKWWLLQMFRYNLRAERTKQEQGNYFVVRRGVSDVMKEAIGMLNDKVGYVYLVDQECRIRWAGSAEAELAEKESMVKGLWRLSQEVRATKEKPSTQQHVESVSDVAEEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q328</accession>
    <name>N1Q328_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_67825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q328"/>
    <dbReference type="STRING" id="675120.N1Q328"/>
    <dbReference type="eggNOG" id="ENOG502RK98">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1001586_0_0_1"/>
    <dbReference type="OMA" id="WFALNER"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="105"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="276" mass="31435" checksum="F9910A943F962DC0" modified="2013-06-26" version="1">MSPLILDYSPESSPSPTRKARPTSFSVSLAKYDDIRRLVDIEFFAFEHEKTNHVLSYRDHNQPAHFQRAVRLYQSAMSKAAALRRQWKAGRSVQQRRAIPDLDAARFRKVVDADSGLIVSWAKTENHAYTAEELGSPADVGHEGESQMNRDWFALNERLRRQYMDTKRHCYIGMVATQPAYQHNGAGTMLLLDILAEADAVGIECYLEATDTAKPLYERHGFVTVNELRFDPAAYGVYGYDIERQTIMVRGALDTRGQRQRVRSWEEAVPGPQAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q339</accession>
    <name>N1Q339_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_68840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q339"/>
    <dbReference type="HOGENOM" id="CLU_2891977_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME50102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="63" mass="6883" checksum="7DE0F510F1EBC5DD" modified="2013-06-26" version="1" fragment="single">MSLDCEASSPNSEIFLCQSNERCDLRSLYPRSSSVSRAVGSEVPKACSSWPPPCYEHSSQGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q360</accession>
    <name>N1Q360_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_67841</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q360"/>
    <dbReference type="STRING" id="675120.N1Q360"/>
    <dbReference type="eggNOG" id="KOG0526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017374_3_0_1"/>
    <dbReference type="OMA" id="QVVTKIF"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.220:FF:000003">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000146">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="376"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="487"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME48914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="568" mass="62991" checksum="A3E241A4CDC59245" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3V7</accession>
    <name>N1Q3V7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_119772</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3V7"/>
    <dbReference type="STRING" id="675120.N1Q3V7"/>
    <dbReference type="eggNOG" id="ENOG502SDS3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159435_2_0_1"/>
    <dbReference type="OMA" id="FYGLYHQ"/>
    <dbReference type="OrthoDB" id="2125027at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME49370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="85" mass="9691" checksum="4B9D48945F92FFC5" modified="2013-06-26" version="1" fragment="single">VQVLRWGALVFGVFYGFSHQQAITSRDKAAAAQHEWDRKQNLINEAKKQFAEKHSKKSGDGVITNPEDPKFDLEAYFKKVAEENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q499</accession>
    <name>N1Q499_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q499"/>
    <dbReference type="STRING" id="675120.N1Q499"/>
    <dbReference type="eggNOG" id="ENOG502SI2P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065434_0_1_1"/>
    <dbReference type="OMA" id="LYAYANW"/>
    <dbReference type="OrthoDB" id="5352400at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="34009" checksum="5EE2AA2CCCE936C9" modified="2013-06-26" version="1">MPRIWFARQWRWPRVMVGLLTVELLLTIACLTLCGIAHPNTYRTRLWQNGFDKGFNSAPNSILYAYANWQTPHTPIVWSHYMTTFNVVISLLSMFILLVKASMYVLHCFIPALSVFVHALLVALYSVSIYNQSRPDMTDVNHPSPGLPWYLSKGCSYATPSNHGYCMQARATFAVVVVMTALFAAYLFYSIWNLRLTEQEKIERDAEHETDLEMKKMCSYEDDDLSKEERRERNRQIFLNLPKTPNTPGFGVHNPMTPRTTAFSQLNGGELPYTRGTGPGGQLPLRESHSFPPPPVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4Y1</accession>
    <name>N1Q4Y1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_20231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4Y1"/>
    <dbReference type="HOGENOM" id="CLU_2333589_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="98" mass="11168" checksum="B1D497DB2BA7ABFC" modified="2013-06-26" version="1">MPFADQSHKHAFPVVEAVARELCDLSKDCIARRVHGEYQEFPECKAKITSEMIAGVRTRAETRGAKDEERLVKKKEREGDAKRVQEVERGKEEELTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q557</accession>
    <name>N1Q557_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_121631</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q557"/>
    <dbReference type="STRING" id="675120.N1Q557"/>
    <dbReference type="eggNOG" id="KOG0332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OMA" id="IAAETRW"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="158"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="358"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME50024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="526" mass="57543" checksum="DB01F10763368986" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2WHX6</accession>
    <name>M2WHX6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_75396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WHX6"/>
    <dbReference type="STRING" id="675120.M2WHX6"/>
    <dbReference type="eggNOG" id="ENOG502SH4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044247_0_0_1"/>
    <dbReference type="OMA" id="FWDGGVS"/>
    <dbReference type="OrthoDB" id="2853639at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="374" mass="42706" checksum="B8FA5935C96FCBA9" modified="2013-05-01" version="1">MSTSQGLLSLPNDVLVLLPDFLHNVEDYTNLSSSSCRLRRCMHHTSPNTILRLAEAQSKIFFRPSPHFLVAATARELGNWARMSKTNEHQLAAICLKGIDGLLELALEHCGLTMDRIRQMHQMRFDLFNPITDIVDKCVGEQWTALPDFWNGGVDDSYTISSEPSDTLFHLVIYGELFGPDFDAVLNQETGVPKLSVDTRLEFMKYCLPDFAVEAGHGRVRDGSVDSRRVVQPVGPYAPDEDGETPHHLNNNLALTWLIRSSRWRPHWKEARALAGEDFQDDFDDGWWYVEDSDQDWRQRMWEAVMLCQGLDGLMMMRPGLRDRWVPKMKEWKEQISKLEREPAAVKVGRQATHQYPFLLGDLRICASGYVGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2WK66</accession>
    <name>M2WK66_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_75147</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WK66"/>
    <dbReference type="STRING" id="675120.M2WK66"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_7_2_1"/>
    <dbReference type="OMA" id="DAVKMMN"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004028005" description="alpha-amylase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="15">
        <location>
            <begin position="534"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME39333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="636" mass="68208" checksum="46DD34BD568F8F50" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2WM36</accession>
    <name>M2WM36_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl-CoA hydratase domain-containing protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_132570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in fatty acid biosynthesis and insulin sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WM36"/>
    <dbReference type="eggNOG" id="KOG1682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_1_0_1"/>
    <dbReference type="OMA" id="CDAQEGM"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052377">
        <property type="entry name" value="Mitochondrial_ECH-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602:SF1">
        <property type="entry name" value="ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME43103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="315" mass="33936" checksum="3A6DA9504823B696" modified="2013-05-01" version="1">MSWPKLPAKAAYLALKNPQRRNALSLAVLRDLKEQLIQYNTSPLDGKLRLLPPFKPEVLNDLEVATCNDSRATIRTSLCWLTEAKKWCQQRKGLPNVIVLRSEGPVFSSGHDLAELRKLSPGEVKETFTLCAEVMQLIRRSPAPVVGVIQGLATAAGAQLALSTDLPIAAAHTHFQLPGASIGLPCTSPATAVSRRLAAPFTYRMLALAEAHRADQLPGGAVEVVANQAALEARTLDIVTKLAEQSAAQPQAFGKWAFWTQFGISGSTSAGGSGGDGYEDAVEWAGRVMALHAKSDDAQEGIASFFEKREPEWKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>M2WMN8</accession>
    <name>M2WMN8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_100177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WMN8"/>
    <dbReference type="STRING" id="675120.M2WMN8"/>
    <dbReference type="eggNOG" id="KOG0967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004299_3_0_1"/>
    <dbReference type="OMA" id="RIDEFWR"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF2">
        <property type="entry name" value="ATP DEPENDENT DNA LIGASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02430)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="6">
        <location>
            <begin position="397"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="681" mass="77263" checksum="9EF8EAFA897AD16A" modified="2013-05-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2WMQ6</accession>
    <name>M2WMQ6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WMQ6"/>
    <dbReference type="STRING" id="675120.M2WMQ6"/>
    <dbReference type="eggNOG" id="ENOG502RXR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025640_2_1_1"/>
    <dbReference type="OMA" id="RLPWEWY"/>
    <dbReference type="OrthoDB" id="5422510at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="474" mass="52557" checksum="98C7772FA5E16DF3" modified="2013-05-01" version="1">MTAVNPPYPPPRTAPATATATATTANTSALPQSAAARQRLSHHNSGNQDASPSPRPDPLRRRSSLISYSSLEDLNQIVNPKTGRTKDRDEDNELTHWHSSPLAFAILPALGGLVFQNGSAFVTDVLLLGLAAIFMNWSIRLPWDWYYSAQTIRYDAEPDADDLDDETAIETGSSAGGSPRPSPNGRVEDRPRAEASAHNTGKREEAVAELRRQERLALAATFLFPVGAAYLLHVIRAQLSRPSTGLVSDYNLCIFLLAAEIRPVRQLVRLAANRTLHLQRTVTGISDPFSSALEEKSTLTDFSSRVAELEEKLSTQANSNPTTAQKTDVSDLSKEMQKRYEPRFDGLERAVRRYEKRSITLAQVTEQRLQSLEARLQEALSLAAVAAQHSQDRGTIAKLLETISNVIAWAMNILLNLTLWPFRTIDDLYIRMKTLLLGPVPPRVAKRKARQEGSDGREDRSRDRAPANMRKIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2XH72</accession>
    <name>M2XH72_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_39022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XH72"/>
    <dbReference type="HOGENOM" id="CLU_1421391_0_0_1"/>
    <dbReference type="OMA" id="LYTIWAD"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="191" mass="22088" checksum="661269B9058AE060" modified="2013-05-01" version="1">MPHQIYAGSKKDQATPVIVRGYFTEYADITYQPRDADDLADVARSEAYLAQVEVLQKAWDLTTCWEAKDVIRNEIRHFQLKRRNMIRLLPTERKVQCCFVEGEIWAAIRQARNILAVHHEPPAQPQTRDGIAYRTTRTPQTKSLKRKRSDSVVECEAPPARRTKVVHLLHVGQSPHRLWEAQKRALHSACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2XJG4</accession>
    <name>M2XJG4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_56931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XJG4"/>
    <dbReference type="eggNOG" id="ENOG502SSTS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037033_1_0_1"/>
    <dbReference type="OMA" id="ICCWISF"/>
    <dbReference type="OrthoDB" id="18595at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="324" mass="35933" checksum="B4FAF8810B1D5631" modified="2013-05-01" version="1">MSPPTNLLGALIFWLYILLALFFTTLVLHTIIRQTSTPPALQSHVAIFSFLAVASFATLSFNMLHVLIQSYILWSAQTDTIGLLREPISLAKVWTWSSCSTLFRDFGEAIVADERRYAWVQWELLGTLSVCLYMGAEGIRRQVPRLWAFFALSQILPISFAQNLFYVAALRSPAAFGLDASMSRNISLRAIAAYCICLAIAPYAAGGPYLISAILFARAMLFVPLVLARKMSQRAGEKQAGRTFFTHQLAQQAVVLFAVALTAKQAYLLYQSKSTARETWKALFSHPAVTALGVDFLLSALGHVAWTLSQNRIRNSALEREKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2XLY0</accession>
    <name>M2XLY0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XLY0"/>
    <dbReference type="STRING" id="675120.M2XLY0"/>
    <dbReference type="eggNOG" id="KOG1299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013933_3_1_1"/>
    <dbReference type="OMA" id="VHQLNNA"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="66694" checksum="033D8F83B79D1DF4" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y122</accession>
    <name>M2Y122_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">DOTSEDRAFT_75635</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="27 28" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="19">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.M2Y122"/>
    <dbReference type="eggNOG" id="KOG0968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_3_1_1"/>
    <dbReference type="OMA" id="GRNKMGF"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000018">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000024">
        <property type="entry name" value="DNA polymerase zeta catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13 20" id="KW-0408">Iron</keyword>
    <keyword evidence="14 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="26">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="25">
        <location>
            <begin position="66"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="849"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="1095"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="1588"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="496"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="621"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="779"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="828"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EME39004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1701" mass="193290" checksum="377C656482652698" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y1B2</accession>
    <name>M2Y1B2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mating type locus 1-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mat1-2</name>
        <name evidence="7" type="ORF">DOTSEDRAFT_192196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y1B2"/>
    <dbReference type="STRING" id="675120.M2Y1B2"/>
    <dbReference type="eggNOG" id="KOG0527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808981_0_0_1"/>
    <dbReference type="OMA" id="MHNNDIS"/>
    <dbReference type="OrthoDB" id="3643217at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="67"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="67"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME39094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="343" mass="37090" checksum="DA231F8356ECCE86" modified="2013-05-01" version="1">MLVLGPEGFEVLRANLEFFTNVRFEYLIDASAGIIGLKPGSPMTSSISASQPSTNGAASTKKSVAKVARPKNAFMIYRLDHHASVLAAHPGMHNNDISKIIGNMWSRESQAVKDEYKQKAEDEKRQHAIAHPGYQYQPRKPSEKKKRMTKNKLAKLAAVSRSTDATTDATTVPAQQNEQTTVDSFTPPYQNNTPQLTILDGTPLATFDVFPGFAGDDGLHDQLALFNSQQPQLPANAGMVAVAAGPLVSDDSWLCLPAEDSLPTTDDGAEAQALAEWASDPTTTSEGARTQDPFAEQYRQEELDKELESLGLYFDVEGASGASGVPDDFAPADTWQPLYTGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y5S8</accession>
    <name>M2Y5S8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_45474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y5S8"/>
    <dbReference type="STRING" id="675120.M2Y5S8"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072096_0_0_1"/>
    <dbReference type="OMA" id="TRFCAYF"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME43604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="261" mass="29820" checksum="B345708E9A3B8FF2" modified="2013-05-01" version="1">MSWSGFKKNVGRATTQVMMKTGHVEKTSDREYEVEERRYRTLESASLRLQKEAKGYLDSLRAMTASQMRIAETIDAFYGDSGAKDGVSRSYKQAVEDLDAETVKALDGPYRTTVLEPINRFCAYFPDINECIKKRNHKMLDYDAMRSKVKKLTEKPDKDPAKLPRTEKETEMAKVAYDQLNEQLTNELPQLIDLRVPYLDPSFEALVKIQLRFCAEAYSRMAQVQQYLAAETRDQYASGDLDARVEDVLGQIRELSIAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2YHM4</accession>
    <name>M2YHM4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_57702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446551">
        <property type="protein sequence ID" value="EME38024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YHM4"/>
    <dbReference type="HOGENOM" id="CLU_2291618_0_0_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="101" mass="10973" checksum="F20EEDDD40A60DA5" modified="2013-05-01" version="1">MSTWGVEISDKNPLEIKRLPIPAPTEDGVLLKILATGVCHVACFSRNTNEADPRILSEFTPGYGGAVEIVELGLKVDIFYPLATQFNSFQAAQSARLVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2YHX4</accession>
    <name>M2YHX4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_29691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YHX4"/>
    <dbReference type="eggNOG" id="ENOG502T62T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060605_0_0_1"/>
    <dbReference type="OMA" id="CFASAPY"/>
    <dbReference type="OrthoDB" id="5342184at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF9">
        <property type="entry name" value="4-LIKE CELL SURFACE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="303" mass="33052" checksum="FD716242566417A8" modified="2013-05-01" version="1">MVNLGGILFPLYIYPYPATRWDPLIAAAQQYRDVTFTAVVNPDNGPGADSTGCPNKDFVGAIAKLNAEPNIVTMGYVHTANRWDCSGPADSQRPGTGTDICFASAPYATVMKNISTYGSWNTCVGWDGAQHDVHMDSLFIDEAPGQDNFKFGAYMTNLTNFAKSNFVNAANNGTVLFNAGAQTDSRYFNVADTIIVLENTEQFYESIPDIDTWVWGSGTKYPSKASILLYNHTTTQGTTSTYNTVAYNVDTILSRKHDAFASVFISNLIGNQYAEFPTDWANITSAVNYTVTANKICVANNTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKE8</accession>
    <name>M2YKE8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_159750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKE8"/>
    <dbReference type="STRING" id="675120.M2YKE8"/>
    <dbReference type="eggNOG" id="KOG0185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072435_0_1_1"/>
    <dbReference type="OMA" id="QPIMRRY"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="275" mass="30576" checksum="9DBC871375A831A4" modified="2013-05-01" version="1">MNHLPQVWGRPRDDVYGAYNPSFLPQSHGGTQQPISHTQQPIVTGTSVIALKFSTGVVIAADNLASYGSLARFTDVHRLKPFNRKSVVGVGGDVSDMQYIDRLLKALDVEENYSTGSHTAEEEDADPAMMSAKNLHTYLSKVMYKRRTDFNPLWNALLVAGLDEKNKPFIASADLLGTTFSAPTMATGFGAHLAQPILRRAVPDEETSQKLTREQAVQTVKDCMKVLFYRDARSMNEYSIAVIDEKGVELKEDEKLENQSWDFADKIRGYGTQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKI8</accession>
    <name>M2YKI8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_138917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKI8"/>
    <dbReference type="STRING" id="675120.M2YKI8"/>
    <dbReference type="eggNOG" id="ENOG502RX7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011522_0_0_1"/>
    <dbReference type="OMA" id="PFNMTLT"/>
    <dbReference type="OrthoDB" id="5294180at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF12">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="659" mass="72924" checksum="A2AA1098A5AB9F09" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLH4</accession>
    <name>M2YLH4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_35234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLH4"/>
    <dbReference type="HOGENOM" id="CLU_1115739_0_0_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="249" mass="27127" checksum="339EB8F8B7EBFD50" modified="2013-05-01" version="1">MVTPGAAGDSTRRLHEALGPVEEASKSSGVSKDERESIVFFSQLLSEFQDGDRQTPGLVAAVHLDAPVKLSFEWSPINVEVCKLYLICIILVQQRGTLSSRFVAEVQLEIQSTITQGDWKDHRTPPSALRLVKQTLHGQRDPICCMPAVSVHTLGHRLRIALTSSNIEVGVAMSSLAQGRVTRQVTTATRLGAGLVARISLVLASGHRRIGLALMQSDAHTFVRGRKRHRCCTISTSASVRITMSAREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBK7</accession>
    <name>N1PBK7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Formate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_48512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FNT transporter (TC 1.A.16) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBK7"/>
    <dbReference type="STRING" id="675120.N1PBK7"/>
    <dbReference type="eggNOG" id="ENOG502QUGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036896_1_1_1"/>
    <dbReference type="OMA" id="FEHTVVN"/>
    <dbReference type="OrthoDB" id="4829at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015513">
        <property type="term" value="F:high-affinity secondary active nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015707">
        <property type="term" value="P:nitrite transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="FORMATE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520:SF6">
        <property type="entry name" value="FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME38221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34087" checksum="6A8C6AE853A74B49" modified="2013-06-26" version="1">MTPSLNGFSPQEISALVTAAGIAKSHLTLGEYITKSFFGGIFISLGGLIDLTTIAGSPDLRSSNPGLATLIGGFLFPLGFVLLTLTNMELCTSNMFVMPFVALQRKVTVWDLVKNWGLTYVVNIAGALFVAGFLGWWSDVLDTDGATAYAVSQAEGRVNVQWSVNFLRGVGCNFLVGLAFFMSLGSVEFVSKVYTIWVPIWAFVVAGYQHSIANYFMVPIGMFYGVNFSVGKFVYQSIIPVTLGNIVGGTLLCAVPFWYLYGRGDAVNVQTGQAAGAHDMQKQLGDSEETVGRREPGANQQNRERYDRSGMVQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBT8</accession>
    <name>N1PBT8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_74610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBT8"/>
    <dbReference type="STRING" id="675120.N1PBT8"/>
    <dbReference type="eggNOG" id="KOG2190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022670_4_0_1"/>
    <dbReference type="OMA" id="MQVVPYS"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="124"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="207"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="408"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="490" mass="52005" checksum="15CDA03459358FF5" modified="2013-06-26" version="1">MAETPTETPVATQKRPLEEPSSPSGPNDQPDAKRPALDKILKEEVADTTEASTEPDDVAVKVVPDVTDKQGDTVVPDAPTNGVQAESTGLPPQQALAAVPTNGTGEDRQSSQAPMPYHQQDESSWLHVRAIISSAEAATVIGKGGENVTQIRRMAGAKCTVSEYTRGAVERILTVSGLVDAVAKAFGLIIRTLNQEPLDQPSTPQSKTYPLRLLIPHILIGSIIGKQGVRIREIQEASGARLNASESCLPLSTERSLVVLGVADAVHIATYYVGSTLVEQLTERFGGPAASNYAGRHGGPQGVVPGGMQVVPYVPQHAGGQMGHPDYNRNKQHAQPQRTPAQPYGGQQYMQGQTPLPPQQAPMGYGAGSPRAPYVGAGPQQPQPYGHAAPQAHAGPPQQPMQGMVPGQPITQQIFIPNDMVGAIIGKGGAKINEIRQLSGSVIKINEPQDNNNERLVTITGTQECNQMALYMLYSRLGESSKNSNSAMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBW7</accession>
    <name>N1PBW7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_75870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBW7"/>
    <dbReference type="STRING" id="675120.N1PBW7"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_5_0_1"/>
    <dbReference type="OMA" id="AQLFCGN"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF23">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME38486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="58901" checksum="0B8E0027A9D7704B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCK9</accession>
    <name>N1PCK9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCK9"/>
    <dbReference type="STRING" id="675120.N1PCK9"/>
    <dbReference type="eggNOG" id="ENOG502ST5Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_280185_0_0_1"/>
    <dbReference type="OMA" id="CLWITDD"/>
    <dbReference type="OrthoDB" id="5428038at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1122" mass="126018" checksum="7765CE4E74CDB0EA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCX5</accession>
    <name>N1PCX5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_75737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCX5"/>
    <dbReference type="STRING" id="675120.N1PCX5"/>
    <dbReference type="eggNOG" id="KOG3135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_0_1_1"/>
    <dbReference type="OMA" id="HHGMLIM"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME38269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="204" mass="21863" checksum="60CA52B18359D951" modified="2013-06-26" version="1">MAPKIAIVFYSMYGHIKQLAEAEAEGIRAAGGQVDLFQVKETLPQEVLTAMHAPAQDSAIPFADPKTLEQYDAFLFGIPTRYGNFPAQWKTFWDSTGGQWQTGAYWGKYAGLFVSTASLGGGQESTAIAAMSTFAHHGLIYVPLGYKTTFAILANLDEVRGGTPWGAGTFAGGDGSRQPTKAELELAHKQGEAFYGAVAKVNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCY6</accession>
    <name>N1PCY6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_74860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCY6"/>
    <dbReference type="STRING" id="675120.N1PCY6"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OMA" id="VPEHYEH"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME40172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="534" mass="60348" checksum="44CA14863784BD1B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD42</accession>
    <name>N1PD42_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_82723</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the OSBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PD42"/>
    <dbReference type="eggNOG" id="KOG0045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_240732_0_0_1"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25435">
        <property type="entry name" value="PalB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="9">
        <location>
            <begin position="151"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="962"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1262"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="962"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME40004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1706" mass="191370" checksum="A69E2966E68BED73" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDB2</accession>
    <name>N1PDB2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_158763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDB2"/>
    <dbReference type="STRING" id="675120.N1PDB2"/>
    <dbReference type="eggNOG" id="ENOG502SHWS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004184_7_0_1"/>
    <dbReference type="OMA" id="CEHIGNF"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="637" mass="71553" checksum="114FF3DC2D7CE600" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE44</accession>
    <name>N1PE44_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE44"/>
    <dbReference type="HOGENOM" id="CLU_2793950_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="68" mass="7677" checksum="807877E25D93448B" modified="2013-06-26" version="1">MSRGERHFFAGALMYDTCTNRVVRVLPHEATVPWNHQIPFSRHVGLADDLRGLYQTSGNPFSVFIGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEF7</accession>
    <name>N1PEF7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEF7"/>
    <dbReference type="HOGENOM" id="CLU_2960710_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="59" mass="6909" checksum="7B7E2EAF109AC8FF" modified="2013-06-26" version="1">MQRRPGSNQIRRRSKREFKAKLHNYSQQGRRSPHSPGQHIIGRPLSAQPWRTAALVHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEY6</accession>
    <name>N1PEY6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_36630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEY6"/>
    <dbReference type="HOGENOM" id="CLU_1652111_0_0_1"/>
    <dbReference type="OrthoDB" id="3650523at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="160" mass="17798" checksum="EC20E42C851A1B00" modified="2013-06-26" version="1">MDDMCLVLHGQEPSDFRTKLTEGTSEEDILKIVNRLLLAVVIDKYACVDRLRLQTSGLVSKLIEAVARKSDPDEWTSQLVTTCYLLDNQHGFRISTERLTRETMGFSEDEDRPQRVPSSIMPDGIKGLSEGFSGMDAAWNVVEEAMSGICLECIRAGNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF43</accession>
    <name>N1PF43_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_74294</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF43"/>
    <dbReference type="STRING" id="675120.N1PF43"/>
    <dbReference type="eggNOG" id="KOG0360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_5_1_1"/>
    <dbReference type="OMA" id="RGPNDYQ"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME40699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="588" mass="63470" checksum="5DC8BDC93AD6C56D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFY3</accession>
    <name>N1PFY3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DOTSEDRAFT_46296</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFY3"/>
    <dbReference type="STRING" id="675120.N1PFY3"/>
    <dbReference type="eggNOG" id="KOG4540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028295_0_1_1"/>
    <dbReference type="OMA" id="TYHFGHT"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000129">
        <property type="entry name" value="Autophagy related lipase Atg15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109073" description="triacylglycerol lipase" evidence="20">
        <location>
            <begin position="24"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="21">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="525"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="526"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EME41267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="660" mass="72000" checksum="E2CC2F9B9FB2C412" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG26</accession>
    <name>N1PG26_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cercosporin MFS transporter CTB4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cercosporin toxin biosynthesis cluster protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_81674</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">MFS transporter; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin. The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl radical, superoxide, hydrogen peroxide or singlet oxygen upon reaction with oxygen molecules. These reactive oxygen species cause damage to various cellular components including lipids, proteins and nucleic acids. Responsible for secretion and accumulation of cercosporin, but does not play any roles in self-protection against the toxicity of cercosporin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG26"/>
    <dbReference type="STRING" id="675120.N1PG26"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_3_1"/>
    <dbReference type="OMA" id="FAVQMFE"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="7"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME41322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="447" mass="48749" checksum="5CAA8551761FAA81" modified="2013-06-26" version="1">MGKKVFQMVIPICVGILAPFGSSVYTPGLEQVMSDFGTSTEVALLPFVFYLLGLSFGPVLAAPVSETYGRRIVYLSALPVFAAFTIGAGFSTNITSLVICRFFAGLVASPGLAIGSGSTADLYRPHKRAIPMAVFVTSVQMGPVLGPLIGGFVTEKRNWRWTQWVILFGIAIVLAITLGAKETYKDTILKSRARRLGIKGPPEPQRTPIEYFKYFAKKTIVRPLHMTATEPIVLFWNIYTAFLFGLLNAFFAAFSYVFKTTYDFGLGSVGLTYLGQAVGSVAGLTIIVFISETIWAKELAKIRETDLTATLPTEKKLILAKLGAPLLPASLFWFGWTARPSIHWISPVAAEALFSCANLLIFTCALMALQDCYGAQYGASAASSNTFARYLAAFVFPLFAVQMFEGLGTGWAASLLGFVSLLMLPIPFVFQRHGESIRAKSKYRPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGY1</accession>
    <name>N1PGY1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_26989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGY1"/>
    <dbReference type="eggNOG" id="ENOG502R9YW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_727669_0_0_1"/>
    <dbReference type="OMA" id="IQVQFFY"/>
    <dbReference type="OrthoDB" id="3647132at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="43803" checksum="5A0A4BA3638A599D" modified="2013-06-26" version="1">MIVTGHHSSVKDVREAKKKRACIIREDIREAAVRCRRTKISTSKQQANRPRTSTHVMSTRAITMQQSCDAVIDTAELFEAILLQLPMTDLINYRLVNKTWFRTIHGSPRLMQRLFLAPKMADSHPLWIYDHQHITLKEYTTRDVDLRAIQTKSQYAAYETWRKQHRMMRPSILNPIMLTSDASQLRGSLLRRASHCEIIRLRFSPNLRNLGSPNIYHEMFLCQPPVEEIQVQFFYHLDKTMRRGRPLTTGQHGLVVRREGGVKFKDILETFLEHVEAGSFLLPSSNYHIEVRPEKFSSVVYLLGAIFADEGEIGQIEGSEEIKVLSPMAKKMMRRESHAGLQPFEREMGESYWSKEDEDWTAVALDASDGNPFGGNEAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH18</accession>
    <name>N1PH18_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_46922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH18"/>
    <dbReference type="STRING" id="675120.N1PH18"/>
    <dbReference type="eggNOG" id="ENOG502QTHB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022614_0_0_1"/>
    <dbReference type="OMA" id="CADTCAL"/>
    <dbReference type="OrthoDB" id="2163411at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF6">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME40601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="56450" checksum="958BDCACC8C42CCD" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI96</accession>
    <name>N1PI96_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_133216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PI96"/>
    <dbReference type="eggNOG" id="ENOG502SE6C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2122015at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007008">
        <property type="term" value="P:outer mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035195">
        <property type="entry name" value="Emr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17237">
        <property type="entry name" value="Emr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="51" mass="5800" checksum="F8A278F610E870AA" modified="2013-06-26" version="1" fragment="single">SNLPNLRRLFVEARTEVEESAYSRNAFYNLVLFMSSVAIFSLAAQRMNGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIU6</accession>
    <name>N1PIU6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_135895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIU6"/>
    <dbReference type="STRING" id="675120.N1PIU6"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_17_1_1"/>
    <dbReference type="OMA" id="RIMLGEC"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="579" mass="65189" checksum="A543DC844748C10C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJD4</accession>
    <name>N1PJD4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJD4"/>
    <dbReference type="STRING" id="675120.N1PJD4"/>
    <dbReference type="eggNOG" id="ENOG502S65B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096918_0_0_1"/>
    <dbReference type="OMA" id="PISREWV"/>
    <dbReference type="OrthoDB" id="4157259at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="141" mass="15320" checksum="2FF2FDBCE79893FF" modified="2013-06-26" version="1">MSSSIAIPKRKQAAVVAESSSSPNSYGSSTMGLPMNKGKQRASDGVPSSCSPISREWVSPRRPSLLGNSLSKSEYTVINLAHSEAPPRLVTCVKSSQGFNWNQELFLPSYADYDSHDLEHRPDPVEDIILTDEEAAAMLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJF8</accession>
    <name>N1PJF8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1917-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_54666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJF8"/>
    <dbReference type="eggNOG" id="ENOG502SG47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051869_0_2_1"/>
    <dbReference type="OMA" id="RPIYYKC"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43551" checksum="619558BF4DB3236F" modified="2013-06-26" version="1">MAVDHFIDGDGWISDDSDFNGDERTCQKLEKEATCPWKRGFVASINPSAFRKVKLTNPEETPMAEDQAPQCRPASQQDILGFLRSRPQLQRLAKTHNKELEPPKQEAAWTVAGKLSPDFVTVKRSSVAEDEWRQDETIEEFLRRVPVASPASARVGPWLWAHSSKVPYKQAAANRKHVNMAPFSIGGEAFDLLQACRVQRAALERRNPGKEEGTITRKMGPHRDRLEIDLLKLAVENNVTSGKWMFFPSPQDLPNYWRIIAVATSQGRLGPVSKVGTYNDSEPNTLICVYTYDFSDIEDVRRVLNELVDRGLVAHNSKPIHYKCDAYTHVGLTSGNPYKLRASLYSSKEILQNDAEVLQDGPVARLKKRNKKVDDFYNLFAGDDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJH6</accession>
    <name>N1PJH6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase family 28 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_25897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJH6"/>
    <dbReference type="HOGENOM" id="CLU_711786_0_0_1"/>
    <dbReference type="OrthoDB" id="3642924at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="42803" checksum="CFD102974F7E7296" modified="2013-06-26" version="1">MGNIISTSCHCFKTLQLPAELRNEIYFLALTHDRQTGSRATSALLLTGREVYAEAVEVLYAQSTLSMGVAPCHDYWFKDRAVTLTNDIRYRDKSYGQSMFCPSSGISRPLPIHTLKIWDLHLHPTHSPYYQGPISENSGCSSDTHGTLVKLVKMLGQDENLPREIAYAFMLQLYTGAGRRRNSPALVNLELMFEPLYTLTATTKIEVYSHTFAVPVWAKPYVSAPLSASINKGWDRISRNMQTLTEHDVLPRIAYCVLQEVHGSNSSSSWTDRPQIFATSPSQTSLLTVDGLRLSPSRNAQSSKEVPWYSGIVIQGTFEISDITLTNVLGSIHASTVAINQCSGIAGGCDGIRIQDVAVKHLGSSANATEANAYRYLCSEADEPIGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJK0</accession>
    <name>N1PJK0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_26300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJK0"/>
    <dbReference type="HOGENOM" id="CLU_1713212_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="153" mass="17147" checksum="B6B0D5470EA257BB" modified="2013-06-26" version="1">MRCQPALIRVSRQIDRRTLLMFYGMNEFVAYTPGGGEPGQEMRLSDAHKILKAIGKRNAACIKHVAVLLADCMSDYNLPCLRDDLGFDQFELSPKAVKVLANSGGEPQYVGVFIPIIEYGNARSSITIIEKDRRRRGHYWSARQVDGGGYQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJN5</accession>
    <name>N1PJN5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1349 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_26879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJN5"/>
    <dbReference type="STRING" id="675120.N1PJN5"/>
    <dbReference type="eggNOG" id="ENOG502S8JK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077442_2_1_1"/>
    <dbReference type="OMA" id="PDIWRTP"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23782" checksum="6739010D73B928F9" modified="2013-06-26" version="1">MAGKWHTQNNAPAINDPTADTFKITALPKTDIWRRTDDDDVFNAPIIYQKLKSSDFKSISVTIFAPWKTQYDQGGIILAFPSKDGDLKNSKWIKAGIEYHNNVSILGIVGTDRYSDWSISPMSQEHHQKARFKFERQGETLWVYGAQEKGDGELGPMREVKWAFMEGRLEQEVWVGVYAAKPTTNDDDVEGEVGVQVTFSRLEVEFEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK87</accession>
    <name>N1PK87_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_73924</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK87"/>
    <dbReference type="STRING" id="675120.N1PK87"/>
    <dbReference type="eggNOG" id="ENOG502RNPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065428_2_0_1"/>
    <dbReference type="OMA" id="HAFIMSC"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="9">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME41686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="219" mass="23494" checksum="450DCB2B38A8CE73" modified="2013-06-26" version="1">MSTTPTPMVTHVLEAHGVCGSLTWAILFPIGAIALRLINSPKAWLIHAFIMSCSLIIFAVNIGTGLWVVMDSWHKKIGDLNRGLGIGNAHTIMGLAVFAFALLQPFLGLAHHFMQKSGAWSKRTFVGAVHVYVGRLLILMGIINGGIGLLWSAESTRAENIAYGVVCAVVWVVYILMSLGYEVKRENSSVDRAKSLAGSDRSGSGSLSSPVEGDAKFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK91</accession>
    <name>N1PK91_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_23880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK91"/>
    <dbReference type="eggNOG" id="ENOG502SG99">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_387332_0_0_1"/>
    <dbReference type="OMA" id="HEMNAKT"/>
    <dbReference type="OrthoDB" id="3847937at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="713" mass="81177" checksum="49165A2C48823DE1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKC4</accession>
    <name>N1PKC4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKC4"/>
    <dbReference type="STRING" id="675120.N1PKC4"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028281_0_0_1"/>
    <dbReference type="OMA" id="AFQICAM"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="7"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="319" mass="35849" checksum="281FF3B5C74B3E8B" modified="2013-06-26" version="1">MTSNHDGRLYTLQIIPGKGKGLVASRKIAPGTLIINEPALFTTESLQNAETIEKDLAALVKALPKDSQRAILSLHNNFPGANPFSNIIRSNGYPLGPSSDIGGVFPETARINHSCRANAQHAWNEKLQRMLVHAVREIAEGEELTLSYIIGGPSEERRSNLKNLFTFDCGCELCSLPKDQLKQSDERLRRAQCLDEAIGDAKVVRQTPERALEDCRALLQIYQEEQIYDLRLPRLYYDAFQICAMHGDRARAAIFARRARETRVNCEGAESTEAERLHVLAQDPTKYENAGVTSKWKSKIADVPQESDGFEKWLWRQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKH0</accession>
    <name>N1PKH0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_72974</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKH0"/>
    <dbReference type="STRING" id="675120.N1PKH0"/>
    <dbReference type="eggNOG" id="KOG1984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004589_1_0_1"/>
    <dbReference type="OMA" id="INPFMTF"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="12">
        <location>
            <begin position="311"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="13">
        <location>
            <begin position="390"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="15">
        <location>
            <begin position="657"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="14">
        <location>
            <begin position="753"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="11">
        <location>
            <begin position="880"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME42055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1046" mass="114340" checksum="CAA26E8A30DFF5AF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLE0</accession>
    <name>N1PLE0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_81275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLE0"/>
    <dbReference type="eggNOG" id="ENOG502SX24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087045_1_1_1"/>
    <dbReference type="OMA" id="MSSHPLE"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="213" mass="23806" checksum="12EDE27A31D1B6C8" modified="2013-06-26" version="1">MPALPYHDPTFESDARALDTRQLRRATTTIAHALSHTARSMLNRIPHILSKRQSGGVLAIPTQYQGIDAGPAPGAVAGIVLGSIAGFLLLIWILWIASSGSGFIRSSTLTEEDVVVRRRSRSRGTRRSHARTEMTSRSPRRERVIRQERIVRDSVPPPRQPSRIRETVLVDDMRGPPERRVDGDDIVEVIEEHSSIGVPEPRRKNRRSSGGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLL2</accession>
    <name>N1PLL2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_26039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLL2"/>
    <dbReference type="HOGENOM" id="CLU_1627006_0_0_1"/>
    <dbReference type="OMA" id="YIRTINY"/>
    <dbReference type="OrthoDB" id="10596032at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="163" mass="18022" checksum="213CF03983A252DC" modified="2013-06-26" version="1">MRGPVEYVRTVNYKDRTAATKKAVAEAEAKYDRDMADLERMSLTKPGKWRKVRNSSAHEKVCGGSPLRRELKAMNLEEVVVDGVADGRESKDDSPSPSSLGGILSHAENEGVLEESAKKQPERGGNGVTKPEFPRDRDGKVQMLDSGSELLCRCRTGYLCEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLM7</accession>
    <name>N1PLM7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_152248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLM7"/>
    <dbReference type="STRING" id="675120.N1PLM7"/>
    <dbReference type="eggNOG" id="ENOG502S3RW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124044_0_0_1"/>
    <dbReference type="OMA" id="ATYEINF"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10540">
        <property type="entry name" value="SET_SpSet7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="18"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="167" mass="18589" checksum="1EF626DBC0ADCC5E" modified="2013-06-26" version="1">MAVGLDVGDGDIVLERFQPLSLVLSTPKGRGVFAGAHIPAGTIVDISPVLILDPKENVEHIEKTSLYHYTYNWPRKTHSGTIITTQAVILGLGSMFNHSTDDQNIGWTRKLDKEVIVYRALRDIHKGEELCISYGNHLWFVDTDAEKSRSESEVGEDMLGRIELDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLT9</accession>
    <name>N1PLT9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_64116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLT9"/>
    <dbReference type="STRING" id="675120.N1PLT9"/>
    <dbReference type="eggNOG" id="ENOG502QRYC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_553311_0_0_1"/>
    <dbReference type="OMA" id="VTMTMIW"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053268">
        <property type="entry name" value="Woronin_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641:SF2">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_2G08060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="500" mass="56357" checksum="022E0B42C41E4638" modified="2013-06-26" version="1">MHITDLESQLGQLAAENRALREAREYADQTNDTARHVNGQALQESLAARDQELQQKDHEISVIKAMLQPLQEEVARLTEMNGGLTEANRNLVDDTNGRYATLQAEHAHAHEQWQSAAQELDGMRSEHGRVTSGMKDIVEAEIATALADKNAEILRLREQLDIAAEQIRALQVQIQSSKSSDFLCQRDEDYFDGSCQKLCQHVQQWVLRFSKLSDNRICRLSTDLNDDKIEARLDNAVLDGSDVDKLLGERVRRRDVFMSVVMTMVWEYVFTRYLFGMDREQRQKLKALEKLLAEVGPPRAVSHWRATTLTLLSKRPTFDKQCTLDTEAVCHEIFGVLCSLLPPPSNSEQQLLTSLQKVIRIAVDLAIEMRTQRAEYIMLPPLQPEYDTNGDLVRKVHFNASLMNERSGFFSSNEELAAEQAVVKIVLFPLVVKKGDDYGEGEEEIVVCPAQVLVQNDGGKGKKIVRVMSGAMEIDDPIRSRQSKKRRCGLAEGAVTIGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLU2</accession>
    <name>N1PLU2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLU2"/>
    <dbReference type="HOGENOM" id="CLU_2026687_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="122" mass="13630" checksum="7D33BC2AC20C37AF" modified="2013-06-26" version="1">MRYTSTRPYKRRELHLVSQTFCASMSSPHPPNRERSAAQVKASSSQKSLTIVDIRRIAEVSIVQVHQVLGDIRVCETMMRAPIVKRNGAVQQCCHLWSSPVCQIDGPSTALPCPARSRTPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLX4</accession>
    <name>N1PLX4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_152403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLX4"/>
    <dbReference type="STRING" id="675120.N1PLX4"/>
    <dbReference type="eggNOG" id="ENOG502RA4W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030126_0_0_1"/>
    <dbReference type="OMA" id="RHNIAHD"/>
    <dbReference type="OrthoDB" id="10262962at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF195">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="414" mass="45631" checksum="B65361AFC78A5487" modified="2013-06-26" version="1">MPHTNVQTYTKASDEYKLEYVEVIHRHHKRTPYAANTFPKEGYAWYCSDEGLFYGGKPLNPSGNDSASTFWSVYTSDSNPLAPQGFNGTCQFPQITREGLDDSHQHGADLKSVYSDLLGFIPKAYDAKTVSYRVSNNFITSQVASMLIAGMYPSRAAKDTPLLIQPDSIDSLEPAYTCSSASSLFSSYGSGSSSPAWLEHIHASRDLFVRLDALSGVDSNDSGWHMSYDHYFDNLSARLCHDKPLPCNVNNTSDCVSLAEAEQVFRLGEYEYSFIYRDSNQSLPASTGSYGIWMAELAQNFRHAMGDGVSFTSNTTSANVKYRQNVAHDGSISRLLSILQLEKMVWPGMGAEVVFELYSKNGCYYLRVLWGGQILQSSHPAFGTMDMVPVGTFLAYIDGLVGVGASKIPAICDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM19</accession>
    <name>N1PM19_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_72112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM19"/>
    <dbReference type="STRING" id="675120.N1PM19"/>
    <dbReference type="eggNOG" id="KOG3901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076665_1_1_1"/>
    <dbReference type="OMA" id="QLMKDAD"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME44537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="166" mass="18517" checksum="AC487B7C14DCFBC5" modified="2013-06-26" version="1">MTEPRARPRPKDRTNFSDPDLRGLLYAFGDSSSGSLPETIRVLDEILTDFIIESCHIAATSASYSRRQKIKQDDFRWVLRHNGAMLGRVNEQLAREKVLKMQRKAIDFDGMAGKENAADLADLAEVGGAEEELKKKGRGRGRRKRKADGNAEGEGLETKKAKKTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM24</accession>
    <name>N1PM24_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_88661</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM24"/>
    <dbReference type="STRING" id="675120.N1PM24"/>
    <dbReference type="eggNOG" id="KOG0352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_9_3_1"/>
    <dbReference type="OMA" id="CRWQFLL"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001834">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="36"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="260"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME44542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="485" mass="55497" checksum="4DEF1DDB8CCB0A92" modified="2013-06-26" version="1">MPGVPARKLGQKVDLDFTLRKVFGRDGFRPVQREVVIGALEGHDIFLQAATGFGKSLCFQLPAVVDYGITIVISPLLALMNNQIASLRAANIRVETINSTTPLSAKTAILDDLKTGHPLTRLLYVTPEYCQLDHFRKHLRIVHQQKELARIAVDEAHCISEWGHDFRPSFKDLKFFKDEFPEVPLICCTATATKQVRDDVIRTLALNPDTLQSYTMTTSRPNLHIDIRFTSDDVDRYDDFIKWIKNVHARRANNPTRSQELSQRKERITSFPGIIYTWYRKDTEALAARLQSDDIGAKAYHAGLSVEQKDDHLHGWIQNKEGYDVIVATTAFGMGIDKDNVRFVAHWQMPKSFEGYYQEAGRAGRDGKASLCIMYYSREDRDRAAFVMRREAEKTFNKQGQNRDGQIMRGRSLQALIGYCENATACRHKLIADYFGEKERPPCDYACDWHKDPVTLARRKEQDLSSEEWIATQRQTGTYDCEGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP78</accession>
    <name>N1PP78_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_71926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP78"/>
    <dbReference type="STRING" id="675120.N1PP78"/>
    <dbReference type="eggNOG" id="ENOG502S3WQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048475_1_1_1"/>
    <dbReference type="OMA" id="EVMRKSI"/>
    <dbReference type="OrthoDB" id="2924818at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="6">
        <location>
            <begin position="42"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME44249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="241" mass="28086" checksum="E5D60B395567E6FF" modified="2013-06-26" version="1">MDISPSSSLSFHLSCSSNPHFPTMPLTTTNDTSSSSARNTIYFAYGSNLWRDQMRMRCPTSTHLGIARLEGYEWIIYERGYANIVEKKPQARVHEDQHDYTNEVWGLVYSLEISDEHRLDGNEGVPIAYKKEWIKCEHWPVETSHDNNSKDRAPDLEKEPKETEMLVYINRDSRQVGKIKDEYIHRMNKGIRDAVKEGMPSEYVKQVLRKFVPEKEKEDDEAKELASRQARKFVEARSREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPB3</accession>
    <name>N1PPB3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Opioid growth factor receptor (OGFr) conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_43628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the opioid growth factor receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPB3"/>
    <dbReference type="STRING" id="675120.N1PPB3"/>
    <dbReference type="eggNOG" id="ENOG502S3JY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068726_1_0_1"/>
    <dbReference type="OMA" id="VTESSKW"/>
    <dbReference type="OrthoDB" id="9030204at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140625">
        <property type="term" value="F:opioid growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006757">
        <property type="entry name" value="OGF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039574">
        <property type="entry name" value="OGFr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015:SF2">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR (OGFR) CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04664">
        <property type="entry name" value="OGFr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Opioid growth factor receptor (OGFr) conserved" evidence="2">
        <location>
            <begin position="15"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="203" mass="23172" checksum="3B79B4E0F91C4B73" modified="2013-06-26" version="1">MAPYSREDKPKPFIVRFYGAEAAKDEEGRTLDDILNYEDGELEYHHDYIQVLFPLPEPSPVNPGAPLIKKGTRTAFLESEELRSQLFRAFTRMAGFYAFNVKGDAAAPALDTKPDFRKLAQNTWLTRVDHNHLRISRIIRCLRILGLHETAQVFHQALQDNAEGVSSRSLMYWERAATRPLHLPPSEDNENAKGVAWLKPVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPG9</accession>
    <name>N1PPG9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_22951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPG9"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1013927_0_0_1"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="43"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME44833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="276" mass="29655" checksum="D573E1B792FBAA37" modified="2013-06-26" version="1" fragment="single">MADTKPVDTILHHEDMNHLEKNEHYDTDDSSTDQELTWTWKKIVATASLCGVWVGAQIPLYFIGGSLSYVVADLGSPSVSSWLTVSYTLAIGAIAPFCGYLADILGQRNVVLVGELLVIVGLIIVGTAHSFSQACAGMGIIGGGAAITELTALAGISSIVPVKKRGTYLAICTAFLFPFTPYVMYTQLLSTRSTWRWGMWICLIYNGLFGLGLLATFFPETKASRTVPRGEILRKIDYVGAVLSITGVALFLVALGSGGYTHSWSSAYVLSTLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPT3</accession>
    <name>N1PPT3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPT3"/>
    <dbReference type="HOGENOM" id="CLU_2849661_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="65" mass="7015" checksum="911B39D3790BD44B" modified="2013-06-26" version="1">MPTTLVLTRLTSISTSPAHHFGTSFTRSPSSRPQVIRPQSLADSPAIHLTCQSQETPACQLVKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQZ7</accession>
    <name>N1PQZ7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_87355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQZ7"/>
    <dbReference type="eggNOG" id="ENOG502QTVA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017511_2_0_1"/>
    <dbReference type="OMA" id="CFIGWAG"/>
    <dbReference type="OrthoDB" id="2016285at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME44844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="63143" checksum="18068E1713666B7E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRI2</accession>
    <name>N1PRI2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Expansin-like EG45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_52422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRI2"/>
    <dbReference type="HOGENOM" id="CLU_1447874_0_0_1"/>
    <dbReference type="OMA" id="CINCAGP"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109547" description="Expansin-like EG45 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="18147" checksum="B686AB9ABB0D8935" modified="2013-06-26" version="1">MARITFVPIMFSALAAASTYTGVATFNDYAAQSNTVCGSKTGTSGTYGAAIGDLSPDIWSGNKCSGSIDTSKCNGQSPISGYSGPACPTTTCGKCFKVCNKGGYGGASIGGVGNCVVVDIIDACPSESAYNFCKTDVPADERCGSGSTNALDIDESAYKALTGEAFGSGPNLEVSITPASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRM3</accession>
    <name>N1PRM3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRM3"/>
    <dbReference type="STRING" id="675120.N1PRM3"/>
    <dbReference type="eggNOG" id="KOG3035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051989_0_0_1"/>
    <dbReference type="OMA" id="VIWPKVI"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="267" mass="30326" checksum="4DD14475BEA4C6F1" modified="2013-06-26" version="1">MVQADFKVDQFLLFGDSITQHSFSQQRGFAFGAELSNSYVRRLDVVNCGLGGYNTRQALQVLPHALPRPKCAKLRFMTFFFGANDARLPGTPGGPQQHIPLDEYRQNTIELITHRDVLAHQDVRRILITPPPVDERKCLENDKRNDPSFPDVIKRKASVTKEYAQAIREIGNEYEVQVLDLWTVMIAKAGGNPDDPEPTGSIEVPRNEVLQSFVHDGLHLSPTGYRILYDEMMTLIARKWPDQMPAKLPFVLPGWDNQNAWDLRTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRY9</accession>
    <name>N1PRY9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRY9"/>
    <dbReference type="eggNOG" id="ENOG502S77Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067175_0_0_1"/>
    <dbReference type="OMA" id="NYCTVCE"/>
    <dbReference type="OrthoDB" id="3599883at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="339" mass="37174" checksum="0A9E55DE1EEC8D12" modified="2013-06-26" version="1">MNKHQQHVRTASQGRKVLPPHARPTKPAPLKRGASYNNAHPQVSSPKSPSFNKTQWRRSVGGGPEEVQSAEEEESGMASFLQFCTTCERQIVTPGAVLYCSEACRRKDVSRPTSLQSLESVTSPSLVRNTSTYFEQASSDIVPQRSPTVVRPLSQTFSDHSLFDPNLSSDSSGESETRRDSDSAHYLDQFYSGFAAASEGQSRSGRPYMHRSSTTTDSYAIPSLVHSPSSSYGTVASNASYRPMINRHHPWNCNCSTSKSIDLVIPYPTAPSSPAQLLKDASLKSGASTETSFRVVEAGDISHEQRTPRGSRRSSERKMSADRSLKQLFSHDAMKASPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS26</accession>
    <name>N1PS26_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_116533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS26"/>
    <dbReference type="STRING" id="675120.N1PS26"/>
    <dbReference type="eggNOG" id="ENOG502T1YW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120766_0_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="139" mass="15758" checksum="805F06D8BCCECED0" modified="2013-06-26" version="1" fragment="single">MFSKPRPVPSKAALKFLCQLAYISSGTAAGVATLCAEERRRRTHIVQKIADNAKRLRQSPRHVHNAAALMEWDEDFGHQDQNQEQGNSLPDVKKMNDAKALRKRYSSLVNRSAHAPELPSFVERGYGQLVETDHKHSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS40</accession>
    <name>N1PS40_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_128981</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS40"/>
    <dbReference type="STRING" id="675120.N1PS40"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_3_1_1"/>
    <dbReference type="OMA" id="DAGGLIC"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME45175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="225" mass="24363" checksum="A9689EB4A5D2216A" modified="2013-06-26" version="1">MAQANGHVSFDAIPDAVEAFAKGEMIIVMDSTSRENEGDLIIAAQDFSPAKAAFMIRHSSGYLCAPITPALAARLELPQMVTHNSDPNRTAYTITIDANDGVTTGISAHDRSLTCRKLAEPDVHKDTFRRPGHIVPLQAREGGVRSRQGHTEAAVDFCKLAGKEPVAVIAEIVEDGEEVPGKAELAGNFGMMRRDGCLAFARRYGLKVVTIEDLVQHMERVAKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT47</accession>
    <name>N1PT47_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_70590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT47"/>
    <dbReference type="STRING" id="675120.N1PT47"/>
    <dbReference type="eggNOG" id="KOG4351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007590_0_0_1"/>
    <dbReference type="OMA" id="NKHGHHP"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="200"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="303"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="373"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="434"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="889"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="825"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="916"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="944"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME46621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1012" mass="112228" checksum="C94756CBF0237449" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT71</accession>
    <name>N1PT71_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nop58</name>
        <name evidence="11" type="ORF">DOTSEDRAFT_70218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT71"/>
    <dbReference type="STRING" id="675120.N1PT71"/>
    <dbReference type="eggNOG" id="KOG2572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_5_0_1"/>
    <dbReference type="OMA" id="MGMRSNW"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902570">
        <property type="term" value="P:protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="285"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="383"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="453"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="528"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME46143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="581" mass="63115" checksum="22C98AE434C6A520" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT79</accession>
    <name>N1PT79_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_71321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT79"/>
    <dbReference type="eggNOG" id="ENOG502S77Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065432_0_0_1"/>
    <dbReference type="OMA" id="WCLSSPR"/>
    <dbReference type="OrthoDB" id="5336366at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051668">
        <property type="entry name" value="ATG33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME45575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="157" mass="16396" checksum="5960A031FE2A9B17" modified="2013-06-26" version="1">MPSSVGLCKVIGVTSLGLLTGVSYTLSTQSLPSLLTLPSAKPASYTLSQTTRLATLHVRTLSSISAASLFLAFYLSSSRVRHPYLLWTGAVAAISGGLNLLMDSGTKHAVAIEDVGDVNGEEVERRARKQQMLEFARAGVAGVGFLMGVVGIWGDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTI8</accession>
    <name>N1PTI8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_52925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTI8"/>
    <dbReference type="HOGENOM" id="CLU_3125010_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="50" mass="5954" checksum="65BA14F45FFBAF1F" modified="2013-06-26" version="1">MMRGFAALRGRSQLLVRASWRRYCRTFRTRTSLYRFMACAGRQLRILGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTV5</accession>
    <name>N1PTV5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_99895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTV5"/>
    <dbReference type="STRING" id="675120.N1PTV5"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_1_1"/>
    <dbReference type="OMA" id="QNWFSWR"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="19"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME46812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="273" mass="30205" checksum="44A126EB578FBFAA" modified="2013-06-26" version="1" fragment="single">VIIHYIICPPPGGTKSKGTVLLVHGFPQTNYQFRRVITPIANAGYTVIVPDYRGAGASSKPWNGYTKEVMAQDLYTLLQKIGVKEKVHLAGHDIGGMIVHSFASQFPDATASIAWGECPLPGTPFYREQKNSLLLWHFTFHSIPDLPELLIAGREKIYLKHFYDRQAQNPDAISAHDLEVYGNAFAAPGSLRAGLNVYRAFEQDADDNVARVGKSGKSKIRCLSLWGGSSFADEKSARAMSQQFYEDVSYEQISGSGHWIAEEKPGEFVEKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUG1</accession>
    <name>N1PUG1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_22635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUG1"/>
    <dbReference type="HOGENOM" id="CLU_1610715_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109608" evidence="2">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="165" mass="17952" checksum="2652FF192DCBBEED" modified="2013-06-26" version="1">MGSGLALRFGMLWVGYLGTINTTVLEASTAPSLTDIGRQTRPQRVANTEGHGVEDSKMRNTSTLLPPSRTTITPKDQKGVLKPQLWQTEFNDLLVCCITPCDAALGGNLREAQNNATSPMRARRILPSTPHWSCQARQALSLNFREVAPNAETPPDTSEAYAVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV35</accession>
    <name>N1PV35_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_70696</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV35"/>
    <dbReference type="STRING" id="675120.N1PV35"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_0_1"/>
    <dbReference type="OMA" id="GWFKPHP"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="34"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME46808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="367" mass="39854" checksum="71180FC121640039" modified="2013-06-26" version="1">MLTTLRMAASRRLSQIAGQTRNASTMKEAVVGKGTKVTIRDVPIPKPGSSQIVTKVVFSGSNPKDWKRAEMPDQPPKNQGDDISGVVHEVGDHVSEFKPGDRVIAFHEMMKPGGSYAEYALSWAHTTAHLPKETSFEEGAAIPLAALTAAVGLFARLRLPEPWLPATKPTPLIIYGAASAVGSYAIQLAQRANIHPLICVAGNSRDHVEKYISRDKGDTIIDYRKGENEIVAAFQNVAQQYGKLEYAFDAVSEKGSYQSICKVLSTDGGRITNVLPGKKYDVPEGVVQNLTTVGSVHGVPDDLKDFGHVYLRYIAKGLEEGWFKAQPQDIVSGGLQGIEKALINLKEGKAKAVKYIFRIEDTPGTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV39</accession>
    <name>N1PV39_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_125706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV39"/>
    <dbReference type="STRING" id="675120.N1PV39"/>
    <dbReference type="eggNOG" id="ENOG502S025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_4_1"/>
    <dbReference type="OMA" id="CEYFSAG"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="28"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME46813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="419" mass="46256" checksum="EF89573225B088BD" modified="2013-06-26" version="1">MGHDVSGDTILAVGCVLIGLSTVAVAGRFYARFWLRRDGGNDDWLILAALIWALAMAVSEGMQVRYGLGSKGQVLSSIDPNFLLAFWATIWPYHLSMGFCRLSVVLQCLRIFPQANHGWVKWFMRALAVANGLNMVWATMSSILTCVPVSKYWHPEQEGHCMSWMILYTTNSTLAMALDFAVAILPVPWIRSLLLPIRQKVLLSAIFILAGFPCVIAAIRVQSLIEVTSKSGSDFSYGILAMLSCAEVYAAIICACLPSLKACWNHLRPRCIRHSHAICHWFPCSSCEYFSAGSFNILPQRLDSWLEGRRRGRHANTVFDTRMPQPQGVADTQQLEVQMSQQAHVQGPGKVVKSTTEQNSNQAAATELGTLIQHFGVLPSITGLSDDTMHETTRMRILPSVTGYTGTTWVESTATTEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVT3</accession>
    <name>N1PVT3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2237 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_61143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVT3"/>
    <dbReference type="STRING" id="675120.N1PVT3"/>
    <dbReference type="eggNOG" id="ENOG502S415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127770_1_0_1"/>
    <dbReference type="OMA" id="RNGCCDT"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.110">
        <property type="entry name" value="Protein of unknown function DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466:SF1">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13545" checksum="81BC1F07F9330766" modified="2013-06-26" version="1">MSKSLNVFKQPLALHSTSPMTGYLRNGYCEVPASDFGNHAIAAEVTEEFLDFSAKNGNDLRSIGGMKGGCKWCLCASRWLEAFEAKGREGDKIVPKVFLNATNEKALGKINLDDLKAFAADKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVV7</accession>
    <name>N1PVV7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF1014-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_70484</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVV7"/>
    <dbReference type="STRING" id="675120.N1PVV7"/>
    <dbReference type="eggNOG" id="KOG3223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069723_1_1_1"/>
    <dbReference type="OMA" id="FEERMMP"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="108"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME46490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23358" checksum="A9899E4BC3091378" modified="2013-06-26" version="1">MAKGENSKKAAGNAKKAEVAGQKAAADNAKKEAAEATEWKKGGKDTSKADAAAAKQAEAARKKAEKDALLAEEEASLPTKGGKGKAAPAKKSRGLDLSGLDAPSSKKELAALNATGIDNALDALTLTTENKDKIDRHPERRFKAAYAAYEERRLDEMKDEKGLRRQQKVDQIRKEFEKHPDNPFNQAHGTHDMSKEEMNALRESEKNKKESFLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW50</accession>
    <name>N1PW50_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_70553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW50"/>
    <dbReference type="STRING" id="675120.N1PW50"/>
    <dbReference type="eggNOG" id="ENOG502S27K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008050_0_0_1"/>
    <dbReference type="OMA" id="RIEMTYY"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08681">
        <property type="entry name" value="C2_fungal_Inn1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037791">
        <property type="entry name" value="C2_fungal_Inn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="874" mass="95746" checksum="1839DA889FED2904" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW61</accession>
    <name>N1PW61_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_86165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW61"/>
    <dbReference type="STRING" id="675120.N1PW61"/>
    <dbReference type="eggNOG" id="KOG0324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033441_0_0_1"/>
    <dbReference type="OMA" id="VTLQMAC"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="7">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="163"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="6">
        <location>
            <begin position="298"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME47746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="64277" checksum="1D68C4C231EDC524" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX16</accession>
    <name>N1PX16_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP proline-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_21682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX16"/>
    <dbReference type="STRING" id="675120.N1PX16"/>
    <dbReference type="eggNOG" id="KOG2330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014435_1_1_1"/>
    <dbReference type="OMA" id="KGEPIGQ"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="285"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="597" mass="66648" checksum="A3E8D980B668E178" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX45</accession>
    <name>N1PX45_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX45"/>
    <dbReference type="STRING" id="675120.N1PX45"/>
    <dbReference type="eggNOG" id="ENOG502T1XE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024064_1_0_1"/>
    <dbReference type="OMA" id="KMHWSPR"/>
    <dbReference type="OrthoDB" id="5311681at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="602" mass="68156" checksum="9F9EACAFE62988FA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXG2</accession>
    <name>N1PXG2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXG2"/>
    <dbReference type="eggNOG" id="ENOG502S0NF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033551_0_0_1"/>
    <dbReference type="OMA" id="NHAWLAL"/>
    <dbReference type="OrthoDB" id="5552418at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="401" mass="44040" checksum="F1BDB59A0379BE89" modified="2013-06-26" version="1">MDYNDPSRRQYAANPYATQQQQQQQHQQQQHGSAPQTTSQYTTPGSVERFRQSSYMGHSPSTVPSTGRAGGDAQQVYPALTASAFAPGQPMQYGTELQGSDVSRQQDAQQYQQYSSNVMYGLAQQPQQATQSSYDPVQRYTQRPGPASETLASQFGAPQTAQYYLGAGTVPTSATMPDLTASHLPSQYQSGAYAQAGPSASQTYASAMIDPTASSAYPAYTAQYAQQSSQSIDQAFNNYQAQIRTIFSKVREGQLYELPGVLLDASHYLLGNAEALGLTRDDDNLHDERIRLWDEFNRAWLTTLQTQYDLVQESMRTSGDPHHPTPPQSIMHSQNLETLSRELVRLCDSVEKHGLVDYQMGVAEEEIMDLLLRCLSQLDPETTSNAEAGAESSASGAARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYF5</accession>
    <name>N1PYF5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_123677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYF5"/>
    <dbReference type="STRING" id="675120.N1PYF5"/>
    <dbReference type="eggNOG" id="ENOG502SS0Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019473_0_0_1"/>
    <dbReference type="OMA" id="ETHANPI"/>
    <dbReference type="OrthoDB" id="5236983at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="74834" checksum="1719C98D73BDBF51" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYI7</accession>
    <name>N1PYI7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYI7"/>
    <dbReference type="eggNOG" id="ENOG502RM0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1210448_0_0_1"/>
    <dbReference type="OMA" id="GCEVSYV"/>
    <dbReference type="OrthoDB" id="3639334at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="191" mass="21274" checksum="FA0AD92A5B8D667E" modified="2013-06-26" version="1">MASCPLLGLPRELRDMITDNVITSHQPFRINCTAQPHLVMRTQSGLDISCKTFQSEHANLLRRAAFTPGNKTVASVYNFDFRQLTTFVQGLKPREVVASNRNRNIIVDLFVLDVNELDLEGLQGWIGVCEATGCEVSYVVQWTAFNMDGIKGLESVIGTHSEGEKILRALAGRSVKCWNWEACQEGLSACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYK7</accession>
    <name>N1PYK7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_145863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYK7"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_0_1_1"/>
    <dbReference type="OMA" id="TCDHRRS"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109201" description="GPI anchored protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="44398" checksum="21D34B2ED5C7679A" modified="2013-06-26" version="1">MLSSIALAAVAATGASAASLRTSASTGYINYTTVTGYFLQDEAATNASTFNYTQSNFGLIDRTYPATEGLTANLTQWQRFERQVDALNAAASLNTVYKVLFMGRHGQGYHNAAESYYGTPAWNCYWAQLKGNATIHWDDAQLTSDGLLQAQIAHNFWKHEIELQKIPHPQSYYTSPLSRCLATANLTFAGLDFPLYYPFVPTVKELLREGISIHTCDHRSNKTYIEGRYPTFEIERGFNEYDELWNGVTAESDSAQEKRMLTLLDDVFTNDDHTWISITSHSGTIGTILDVLGHRSFSLATGAVIPVLVEAKFLPASDAPTTSVESYTTSTWCHNAPPITSVGSEAQGCVCSSTTAPLPSLDTQAPFVPGQTAPIDEYTTTTMVKVSTSVTAYPPSATDRTYPTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYM6</accession>
    <name>N1PYM6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_146227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYM6"/>
    <dbReference type="SMR" id="N1PYM6"/>
    <dbReference type="STRING" id="675120.N1PYM6"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_12_4_1"/>
    <dbReference type="OMA" id="EPPVMAC"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="160"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME47510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="458" mass="51515" checksum="D05F2E7FD3F408C1" modified="2013-06-26" version="1" fragment="single">MWKTAVLFQPSPRVLEYLLRKGRIPAASMAVVAVEERKEDPEILAPPPTVAVTPCDPWPRPYVLDGNLRRVAPYHFTYNTFCKERWRGREILEIFQDEFRDRPVEYYQGAIESGAIHLNGKPVPSTSTKVKNGDIISHTLHRHEPPVTAQPIGVVHEDEDVIIINKPAGVPVHPAGRYNYNSVIEIMRAERGHQFNPLPCNRLDRLTSGVMFIGKHKKAAERITEQLMGRTMRKEYVARVIGEFPSDDVVCEEPILQISPKLGLNRVRANGKEARTVFKRLAYYSPRDGHGIGYSIVRCRPLTGRTHQLRVHLQFLGHPISNDPIYSNQRVWGANLGKASSAGDDDEDIISRLSRMGKEDVAEAVAYHDELVDEYNRKKAEKMTGELCEICDTPLYSDPGAHELGIYLHARKYADADGAWSYETPLPEWALPPPGHDGSKAASLESDPLAVDVEKLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYR0</accession>
    <name>N1PYR0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_67575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYR0"/>
    <dbReference type="STRING" id="675120.N1PYR0"/>
    <dbReference type="eggNOG" id="ENOG502S356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025951_1_0_1"/>
    <dbReference type="OrthoDB" id="4179303at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44654" checksum="7D64196E36FAF381" modified="2013-06-26" version="1">MNDQDTSRPPLPRGLPVELFKLILSYIEPNHEQALPIDKAIASRQFLSVESLEPPDPSHGSVRDSLSTIGNFRLSCKVFEQIGAPFLFTRVATRFSKDGLRKLERLSHWRHLARHVKRFTYLVPYFVKGELSDFDTLQAQLRQGGVQAVDSLALRDKIREQRTTIALKEDARILKKAIASFTSLQLVQILRVTNREDAMLSEYLRRHEEARRVINLDWSSACSHAARTVGTALLDSSNMEWNRFSLPMLSPTSAQFLKLSGPNSVQMLAERLSCLTLHFDDSEDLEAKLQDLSDLFRSVFSKAKKMRAIHIGFPSHRPINLPLESIFHFVQWDDLVAFGVNGWELEDVEIIQFLKRHKGKLRGVRLRDVHLKDGSRWSNVLEAVKYAICSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZE4</accession>
    <name>N1PZE4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BolA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_121368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZE4"/>
    <dbReference type="STRING" id="675120.N1PZE4"/>
    <dbReference type="eggNOG" id="KOG2313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109462_2_0_1"/>
    <dbReference type="OMA" id="CLGGFGK"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11902" checksum="CEB77C477D00D218" modified="2013-06-26" version="1">MASQTPMEDAIRSKVTDTFAPTSLEIFNDSHKHSHHQAMQGVTSKETHFRVNIVSDSFQGKMQPARHRMVYTLLKDELAQEGGIHALQLKTRTTEEEEKAQANAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZF7</accession>
    <name>N1PZF7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_42109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZF7"/>
    <dbReference type="STRING" id="675120.N1PZF7"/>
    <dbReference type="eggNOG" id="KOG2381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009049_2_0_1"/>
    <dbReference type="OMA" id="NWMVKVD"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="161"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="297"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="678"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME47770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="776" mass="89013" checksum="DA297292825C5D38" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZJ1</accession>
    <name>N1PZJ1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_19356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZJ1"/>
    <dbReference type="HOGENOM" id="CLU_1042153_0_0_1"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="31280" checksum="C27C1B2FA7F9212B" modified="2013-06-26" version="1">MPNLWFHNSDASEHDQLCPCTQHHAQLRRGIQTSTMLNRDRMRENLAKARATVRDSVKTCLRRNFTVRKTRDPGKAFALFLDLPAEIRERVYELCADNDRSILEEHFTSAKPPPELAVACASRQLRREALPIFYRHYRFPVTFSSGDWINKGCLPPSMEWKAARWYHRLEPEKLRMIRRLELYYCFGRFQLDFDARSNGYEVRQTAWGSRRMVDVSPVEEKKQLLALLRSVVDDVLKEAGVGMLAAKDFDHLEWEVLPNTAYHRKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZL7</accession>
    <name>N1PZL7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_67483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZL7"/>
    <dbReference type="HOGENOM" id="CLU_2775901_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="69" mass="7662" checksum="A8BD7B3532ABC950" modified="2013-06-26" version="1">MRWCIYLDTIACRPCMWLIEVEEVASSTQIEFAMRSKEDAIAGTGHPGQTRIGRDYIEGPSGDLCIDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZV5</accession>
    <name>N1PZV5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZV5"/>
    <dbReference type="HOGENOM" id="CLU_1326344_0_0_1"/>
    <dbReference type="OMA" id="CEECHEP"/>
    <dbReference type="OrthoDB" id="10463734at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="207" mass="22844" checksum="45F38BCFEB31C434" modified="2013-06-26" version="1">MAQFVAHAHSLVLWHMQTIFTCPASLTYASFRPSRGDVSLNHTRHNIIEPLYDRLPIYTTRDCHATMPGCAACNVSKKRCPGGVRGCLVYQEKKEKQEVMAREGRGEKKGGGPAPRVKSPPQKQVISAEPRRTQQPVTAGQAPTFTQILNAPRAAPPAVNDARIWKESSAVQALRDFPEADQQPGACAECHEPLNAHYFGCSHYVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZW5</accession>
    <name>N1PZW5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_84135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZW5"/>
    <dbReference type="STRING" id="675120.N1PZW5"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_6_1_1"/>
    <dbReference type="OMA" id="PTGQPHI"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF2">
        <property type="entry name" value="ACID PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME48538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="58795" checksum="A4D4135A142F8FCC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZX0</accession>
    <name>N1PZX0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_67553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZX0"/>
    <dbReference type="HOGENOM" id="CLU_2757744_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109731" description="Secreted protein" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7386" checksum="A3CF5FFB85DE32E6" modified="2013-06-26" version="1">MLLLKLSLITFSSNSAFTRLLTLFASATCAPLTHSSPTRAILDEIISSSPSTSILNPSCGNGCLNRAMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q086</accession>
    <name>N1Q086_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_76504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q086"/>
    <dbReference type="STRING" id="675120.N1Q086"/>
    <dbReference type="eggNOG" id="ENOG502RHUH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_818959_0_0_1"/>
    <dbReference type="OMA" id="VNYEMQR"/>
    <dbReference type="OrthoDB" id="10620535at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="339" mass="35721" checksum="3FF84999D8EB8351" modified="2013-06-26" version="1">MPRPFTILKSTVTAPRHTSSKRSSSSPTDNPINMFSTDLEKGADAQTSSGIGPNTSSHQAGADFPPKYESQVNYEMQRVGQAQRHVAKAVDIDYDFLAPSRKQSKRPMWFWAIIVGAVVVMIIGAVIIAVHGANNKQTEEIQVRSSSSPLVTQPKANTTQSPMVTRSEPSASQASMTIMPDLVTVTVEPMTSFVYATVTYPTPSTSTGVVVASEQASTSTPIVTITLTSTESKSTISKSTSSPTSSTVTTVATFEAPVTASPDPTVTIVSTVNLSESALRASISAEMSRVSEHLIARPITQSVVSMTTETAAGASRIPVVSTASGMLFRCTVPGLACGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q198</accession>
    <name>N1Q198_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_18949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q198"/>
    <dbReference type="eggNOG" id="ENOG502SWZV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158092_0_0_1"/>
    <dbReference type="OMA" id="WIMTGAV"/>
    <dbReference type="OrthoDB" id="3649628at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="91" mass="9950" checksum="C74083F7BECA5258" modified="2013-06-26" version="1">MASSRPRVYILTGAVAAITATGAWYGAGLKTRQEFKQERQSVMQASTADRIASMELAKTKLLRQRTEMQNKIDQLSGKATTPPVKKIGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1H5</accession>
    <name>N1Q1H5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_67428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1H5"/>
    <dbReference type="HOGENOM" id="CLU_1849863_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="139" mass="16205" checksum="EB43C20F899E1208" modified="2013-06-26" version="1" fragment="single">QLHSLGLYDYTSTPRYHAPYNNNHRYQPVDTLSNRTTSSPPPRTRTSTQPPQCLRRHSHHAPVQRLLVLFHLSQQSERLATLDSFPRLDSRYSAGCNRNHHKATVLPPRARHGYEIVCHLTLDSKPYLDDDNNKHHRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1Q7</accession>
    <name>N1Q1Q7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_30857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1Q7"/>
    <dbReference type="HOGENOM" id="CLU_1532513_0_0_1"/>
    <dbReference type="OrthoDB" id="3902029at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="175" mass="19431" checksum="6CC4456A8CBE049A" modified="2013-06-26" version="1">MSELQTPTQNPEPSTPNAPKHRHVYLPDYRELSPACLIKALPSTREKCANLKSLVVSSEPDYYTPSFTYLGPPIGFSAKIIEHHTPSGVITTSVYGSLMAPRPRLTIPCDDRWCSTCRTDAGKIAAPRRYTLVASSDTKSPSPRRYISSESTTPTLRTPIAREYASRRSPRPLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q272</accession>
    <name>N1Q272_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q272"/>
    <dbReference type="HOGENOM" id="CLU_818960_0_0_1"/>
    <dbReference type="OMA" id="LHWEEIQ"/>
    <dbReference type="OrthoDB" id="3647306at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="339" mass="38397" checksum="2B31BC41DA79EFBC" modified="2013-06-26" version="1">MMATTQQLSVGHRIVGSAKGLTCSTLSGVSGVEAELRNCLDTITSGKFLAAPQTLERFANRDIPKTAKATRRLSEGFRGDFTKDVDLDPDFEAFARRTEPIELARRRFETRPARKAVLVCDFSRTKSRSQHPGGLRGNSPETVMRVLGWRQTDAQQSASDRSQISSTDNDWGVRGSKSEMMVQPEASTTSRPTMESTWERSQSAAVERLRQFSNQLTGAAATPLSTKTSQQDWIAGELHWEEIQNQQMRERLRVPERRLKYERPDATEPDHLMRNFYCRRLSCHRRLLMQEATLNPSRPARCCVHTGCGYVSQTIAGWERHCATEHNHMEEIDYPSPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q324</accession>
    <name>N1Q324_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DOTSEDRAFT_84402</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q324"/>
    <dbReference type="STRING" id="675120.N1Q324"/>
    <dbReference type="eggNOG" id="KOG1179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_46_3_1"/>
    <dbReference type="OMA" id="HHGLIMR"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF6">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY PROTEIN (CEFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="54"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EME48884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="630" mass="71088" checksum="28A4F0F424D18F74" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q390</accession>
    <name>N1Q390_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_68868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q390"/>
    <dbReference type="STRING" id="675120.N1Q390"/>
    <dbReference type="eggNOG" id="KOG1008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005843_2_0_1"/>
    <dbReference type="OMA" id="YEPTGHA"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="6">
        <location>
            <begin position="453"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="5">
        <location>
            <begin position="803"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME50147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="926" mass="102622" checksum="DC64CA4250E06E63" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3E5</accession>
    <name>N1Q3E5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_68505</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3E5"/>
    <dbReference type="eggNOG" id="ENOG502RGHQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146833_2_1_1"/>
    <dbReference type="OMA" id="TETFEHV"/>
    <dbReference type="OrthoDB" id="2288868at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME49748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="96" mass="10521" checksum="3376253E540D9461" modified="2013-06-26" version="1">MSASPLVAHYTSPKATQSLSYELPPLPEDGANVEQKTSYLAALRAKTTKLQDAVNAYLTQKMDEDKAAENVQAKASKDAEEREEEMYGKEDPEEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3G4</accession>
    <name>N1Q3G4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2461 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_49502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3G4"/>
    <dbReference type="STRING" id="675120.N1Q3G4"/>
    <dbReference type="eggNOG" id="ENOG502RKMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036742_0_1_1"/>
    <dbReference type="OMA" id="CNRENAL"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02453">
        <property type="entry name" value="TIGR02453 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45944" checksum="B0215126C1CB3874" modified="2013-06-26" version="1">MARRSQRLSTGNASAVKHKRSASGPVVSGPIAKRPKSQNASPAQSQYFPPNDGLERRQSQHDNEDSPSSFDESGSDFGANEESALSEQAKTESEDDDDTSDSIDASAAQSHNHAWRPGVRTGLGPGKQLIIKKPKPRSAGKTPYTDHTIHPNTLLFLADLKANNDRQWLKMHDAEFRRAEKDWHGFVESTTEKLMEIDETIPELPLKDIIFRIYRDIRFSKDPTPYKPWFSVAWSRAGRKSPAYAHYYIQIAPNKSFVGGGLWHPESSPTAAMRQAIDRDSNRLKGVLVDDRIRKEFLGSCGRSEAAAVKAFVKCNRENALKTKPKGYGADHQDIELLRLRNYTIGRSLTDEEVLGEAGLLRVAELLTSLKPFITYLNSVISPDGEDADDDESSGDEEHPDDTEHDEDADDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3W9</accession>
    <name>N1Q3W9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_68019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3W9"/>
    <dbReference type="STRING" id="675120.N1Q3W9"/>
    <dbReference type="eggNOG" id="KOG3847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022501_2_0_1"/>
    <dbReference type="OMA" id="EAFMHWK"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="595"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="634" mass="71516" checksum="ED7E03EF405FCE4D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3Z6</accession>
    <name>N1Q3Z6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DOTSEDRAFT_68693</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3Z6"/>
    <dbReference type="STRING" id="675120.N1Q3Z6"/>
    <dbReference type="eggNOG" id="KOG1933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004183_0_0_1"/>
    <dbReference type="OMA" id="EFQFRPM"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109866" description="Sterol regulatory element-binding protein cleavage-activating protein" evidence="18">
        <location>
            <begin position="23"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="602"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="19">
        <location>
            <begin position="275"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="986"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1088"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="990"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EME49958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1114" mass="122387" checksum="BCE1F299F083E725" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q551</accession>
    <name>N1Q551_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_85374</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EFG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q551"/>
    <dbReference type="STRING" id="675120.N1Q551"/>
    <dbReference type="eggNOG" id="KOG4484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066912_0_0_1"/>
    <dbReference type="OMA" id="KCMEEGT"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME50150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="267" mass="30844" checksum="8537893A4ECCEBB1" modified="2013-06-26" version="1">MATKRGAPDSNNDSRDSYLRRKRHKPNAFQPKDPENHGKNSYKKAHTVNDLKKTVRNISRLLERELPANIRVEKERALQTAQHDLAMAGKAKKRSEMIGKYHKIRFFERQKAERRLKKARKGIKEATADGKGREEMEGLRKRVEECEVDVNYAMYAPLEWEYVSLFPRRKKEGEEDGDQDKGEGVERQGNGDMWKRVKRCMEEGTLGDLREGRLEGGGEDEVKELMRSVKKVRKDKKKDSRAEGQKAVMEEKDEDESGDESGGGFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2WHI5</accession>
    <name>M2WHI5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_57656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WHI5"/>
    <dbReference type="eggNOG" id="ENOG502S6PP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069867_0_2_1"/>
    <dbReference type="OMA" id="VYVVRWM"/>
    <dbReference type="OrthoDB" id="509124at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25885" checksum="A3D46836A7F33672" modified="2013-05-01" version="1">MASSTITIWPPAAGLCSPTVPRQDAVFQSSGTCRINAPAALVFENVLRLDKYENWNSFVPEARIVSNRSSRPGPDLTPDEQAAEAVDDNFSHMKKGAIMHFFVIMNSAKPKNTTQTELQVTDISTPDKPSDYLDAEALKDPAYTSDLSKVYRISWKSHGGFVSRGLKTERFHEIIVLGENECELRTWEVYGGVLAHTVKWMYQKTLNAKFQLWADDLRKYSEQNAAQTGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJ37</accession>
    <name>M2WJ37_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_75625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJ37"/>
    <dbReference type="STRING" id="675120.M2WJ37"/>
    <dbReference type="eggNOG" id="ENOG502SJFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006632_3_0_1"/>
    <dbReference type="OMA" id="HIQADDW"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME38988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="796" mass="89003" checksum="23E4F79B992C39F0" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJP6</accession>
    <name>M2WJP6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_75060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJP6"/>
    <dbReference type="STRING" id="675120.M2WJP6"/>
    <dbReference type="eggNOG" id="KOG2596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019532_2_0_1"/>
    <dbReference type="OMA" id="GPILKVN"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME39188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="551" mass="60347" checksum="7610F5732C47DB12" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2WK63</accession>
    <name>M2WK63_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_38539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WK63"/>
    <dbReference type="HOGENOM" id="CLU_2145793_0_0_1"/>
    <dbReference type="OrthoDB" id="10617581at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="112" mass="12321" checksum="9469D5F6AD738412" modified="2013-05-01" version="1">MQKIINETRAQLPDQPALPFIPQMANKTDASPPGHCGCEDELYTSEGCQCYKVVTSADTDLADGLKRGLKRKSPEEDDEMEDDFMCDDAVEEDRSPPAIGVVEKLNCAKASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2WKF0</accession>
    <name>M2WKF0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_75202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WKF0"/>
    <dbReference type="STRING" id="675120.M2WKF0"/>
    <dbReference type="eggNOG" id="KOG1432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019692_1_1_1"/>
    <dbReference type="OMA" id="TYWVPVY"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004028625" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="420" mass="46338" checksum="FA13131456ED2763" modified="2013-05-01" version="1">MLFSVLLFVFLTWCYGSYGAALPFNGVKKRTPQTLRFDKNGRFQLAIFEDLHFGENQWDSWGPQQDINSVRVLNDVLDAETQQLVVLNGDLITGENQYKFNATNKIDQIVAPIVHRGLPWASTYGNHDSDFNLSRTDILAREQRYANALTRSDVKNANAGVSNYYLPVYPYTNSTTPSLLLWFFDSRGGFLYQQKNAAGAKVGQPNWVDQSVVSWFKSTSASLTKQYGATIPSLAFVHIPTNASTALQSEAKVKPHYQPGINDDYILAPQAQGWCPNGKNDGSCAYGGQDEAFMQAITSTPGLMAVFSGHDHGDTWCYKWNTLLPGMNVKGNGINICFGQHSGYGGYGSWTRGARQVVVTEAGLEQGKVDTWIRLETGSVVGRIQLNSTYNHDYYPATPNTKSSCGSCNYSSVTPMPGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M2WKR2</accession>
    <name>M2WKR2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_48035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WKR2"/>
    <dbReference type="HOGENOM" id="CLU_2589725_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="80" mass="8691" checksum="152B48521305DE2C" modified="2013-05-01" version="1">MSGIAGKFLRGKRSPGSCYAMPVVGVQRTNSPNSECQSDAYLLELWHSSAEASAWKRLVGKASIARQPLDSRLPKRLATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2WM40</accession>
    <name>M2WM40_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_72478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WM40"/>
    <dbReference type="STRING" id="675120.M2WM40"/>
    <dbReference type="eggNOG" id="ENOG502QVK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021167_0_0_1"/>
    <dbReference type="OMA" id="EVANNIC"/>
    <dbReference type="OrthoDB" id="5396941at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488:SF2">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488">
        <property type="entry name" value="ZGC:162509"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="765" mass="82102" checksum="4CE42EE384BF6FF0" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>M2WN02</accession>
    <name>M2WN02_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_72697</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WN02"/>
    <dbReference type="STRING" id="675120.M2WN02"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_6_2_1"/>
    <dbReference type="OMA" id="NAMIFKE"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF2">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="25"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME43373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="484" mass="52960" checksum="EED7E844ED520270" modified="2013-05-01" version="1">MGDPGTKHSSTNSKSCKTAIELISQPLTLPCGLTLPNRLVKCPMQETLAEPPNFDPPVEKFQHLYEKWSDSQYGLLITGQVQVDIRYFSIAGDVCTHPGSTSGEVLQEWKEWATIAQAAGTPCIVQLAHPGRMSPVGAGNRSADMQPLCPSSVPVKLGDSWLDKLALDKVLGTPKAMTHEEIDEAVENFVRGAVVARAAGFSGCQIHGAHGFLVSQFLSPYTNRRTDEYGGSYEKRMTLLKRLVKEIRAQCPPPFCVAVKLNSADYMQGKEGLQQDEALEQVKWLIECGMVDFVELSGGNAEQKTSGLQSSFGKKTISEAPKMTESTRIREAFFTDFAEKVQALDSPIPIQLSGGFRSRTGMADAIDSGVCDLIGLGRAAVLEPELPRKTLLNIDVNDDTALAISHQIKGLWFTKFVPTKVIGGRLPIQFFYYNMRRLGSGMTSDPNATLPFVFFHNLWRGLKASIFGPLQRIMMAKAVSSGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2XGU9</accession>
    <name>M2XGU9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_28930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XGU9"/>
    <dbReference type="HOGENOM" id="CLU_1938108_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="130" mass="14775" checksum="8D70DC9941A4274A" modified="2013-05-01" version="1">MPTWSNSRLVNPQQSQELALMCIRRVSNIVVDIHTELVEHIANSLNLRAHLKTPPLDSRTIASRTYDTWQQRRFRQQACFLISQESLEIGIWVAMQLRFGPAVREICFLVEASGDLASANASSNVIRDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2XGZ5</accession>
    <name>M2XGZ5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_38975</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XGZ5"/>
    <dbReference type="STRING" id="675120.M2XGZ5"/>
    <dbReference type="eggNOG" id="ENOG502SDN6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_789942_0_0_1"/>
    <dbReference type="OMA" id="KHIANEH"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004029158" description="CFEM domain-containing protein" evidence="11">
        <location>
            <begin position="17"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="12">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="234"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME38747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="351" mass="40086" checksum="BAC8A740CF3B64D9" modified="2013-05-01" version="1">MWSLLLVAALGAVVQSSFIPECASTCVGEAIDASSCSSADTACICSSREFTPQLHACIETNCEEEDQQDAISHTDQFCAVVQPKKGLRARDAAPEPESESEVDTDFDEEYDEDEEDEEDEELDARDAAPEAEAAAEANREKQPSRYRDHGKEKKGGKGWWEWVKGKGKVWHQGKKQQKEPHHKKPTHKDPHNKKPHHNKGQDKAPQYDQPHNKDPQHDQPHDKEPQYGEPQHKKPEHKKPEHKKPEHKKPHHKKPHHKKPHHKKPHHKKPHHKKPHHKTHKTHRPHKPTPYPPPYQSTTMKTSSTCTDETTRSTPTQTYQQKPHTPTSYSYTTNTSPTASRYSATVIATVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2XHB8</accession>
    <name>M2XHB8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_39045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XHB8"/>
    <dbReference type="HOGENOM" id="CLU_868851_0_0_1"/>
    <dbReference type="OMA" id="ANCGYIR"/>
    <dbReference type="OrthoDB" id="10407128at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="320" mass="36372" checksum="603D7DD7E1741332" modified="2013-05-01" version="1">MSGNWDLLEDAGPRLPLTKERTHSDKIRYAAALAHANNTHARVIEIIEHPDSKVLAIAAQAFQADFERVLPQGVRDVIAHTSPPYIRDGQEVRLPPFSSDKIPESYKQLFFKETKFIVDVQKLAADPSLAGKKWIEFLDFLGDANCGYIRKMAFHFENVTVQLNVRPRIFEIGHEKAGHIRAPLTCFRLESLPGESCFLKQNEADFHQASDWLRQAFQKITTDRERFLKAGRFGMRDINKVGKVVFRLPALCCWLQSQRRGKQVKDREDSGTCLALPTVPERSHSPNRVVNLPTEKELREHAVECEGCDCAWVRQADGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2XHC7</accession>
    <name>M2XHC7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_75539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XHC7"/>
    <dbReference type="STRING" id="675120.M2XHC7"/>
    <dbReference type="eggNOG" id="ENOG502S1A6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_1_0_1"/>
    <dbReference type="OMA" id="NIFPVMA"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME38842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="373" mass="41415" checksum="3FFA4EF3FA5931D4" modified="2013-05-01" version="1">MSKAPELNIPPSTNTVDVSIINTAHTILGLPTSIFYGPKISGHDIIAAPVYSFLIQHPTLDRTIVFDLGIRKDWQNYSPVMTKSIDPDHVTIRVPKTVRQILDDGGVDTAKVESVVWSHWHLDHCGSPAEWPVTTSLIVGPGFENGLLPGYPTNSESPILESDLADRRLIELSFPSDFNIGAMEALDYFSDGSLYFLNSPGHTIGHISALARVTSNPDSFILMGGDAWHHSAELRPSPYLPLPEQISPHPFTNYPTSPCPGALFASILRDGDNTKSFYEPRGPGVLVHYDQEEATRTIEKLQEVDPRDDVLMAAAHDESLLDVVDFFPKKANGFMEKGWVKQARWKFLMDFAKAVGWEGEVKGLRDWSTPKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKW8</accession>
    <name>M2XKW8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_173826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKW8"/>
    <dbReference type="STRING" id="675120.M2XKW8"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="OMA" id="MIGFGRP"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="354" mass="38229" checksum="FCCB205E98DE7DF3" modified="2013-05-01" version="1">MTVPTTRLFEPLQIGAVKLTHRIVMGPLCSNTADENNVLTPPAVKYFSERAQYPGTLIIGEATFVSPRASGTSEPRAGIWTDAQIAGWRDVVSAVHAQGSFIFLQLWALGRCADPEIKKREGTGDVISSSAVPAKEDGVVPRPLTTEEIWSYVKDYAVAARTAVKACGFDGVELHGGNASLIDQFTQDCVNRRNDGWGGSVENRSRFALEITKAVCEAVGADRIGFRISPWSTYQGMGMERNATIEQFSHLLRGLKASGIAYIHLVESRIAGRVDVEAGDSLDAFTESWGEAGPFMIAGGYDPTTARAALDKQYRGKDVAIAFGRAFVTNPDLVARVRGGRELVENKSWTATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y027</accession>
    <name>M2Y027_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y027"/>
    <dbReference type="STRING" id="675120.M2Y027"/>
    <dbReference type="eggNOG" id="ENOG502RH7N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787508_0_0_1"/>
    <dbReference type="OMA" id="VKWDVEH"/>
    <dbReference type="OrthoDB" id="5420711at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="398" mass="46285" checksum="6BF6E83D73EF40CE" modified="2013-05-01" version="1">MAKKRRRLRKNSKRHDPSTEIGHASPARTMNASGTTYSEGHKDRPLKGVQRARAKHANDNVIHQTNAEPSLADRFNALPAELRAEVFSQLIVRPVKWDVEHQHDCQRRNSDYDLTPVTCDIGCAYGAYWSSWRQRLNEGIRPRVSPWRSKWAPEQGNAYLCTDCYYEKALRGGPHPRPSSLLCLCARRQHLEVFLVCKKWYEEAAVVFYTRNIFAFEDGFALASFVAYMNPRWRQIISHVSIMVVSFDIWPDEAVTWVRDRDGTSDDEHRLRLNSVSIWSRLRELPALTYLELDHCFLTRMRTVKRMQRLGLNNVKQVRFTQPVPPDEHPEWMKGTPTVWPSYAGRTLLLEGFAEGMARTIKGQRQKRLKGNSNIEQAIHDFRVKIGEAERTVQWWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y372</accession>
    <name>M2Y372_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P) binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_66268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y372"/>
    <dbReference type="STRING" id="675120.M2Y372"/>
    <dbReference type="eggNOG" id="ENOG502RZY4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_4_1_1"/>
    <dbReference type="OMA" id="SRAFMGW"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="221" mass="24232" checksum="8110633A9BB848C4" modified="2013-05-01" version="1">MHFLILGASGRTGQLTTAEALVQGHAVTALVRNSDSIAQQQGLTIVPGSSLNGDDLEKAFSNQPIDATIITLAVQRESDNPFAKRTSPQYLIRDTIHTLLPVMRKHSVNRLVILSASGVGSSFAQSAWPLRMMFRHTNLSYAYEDHDAVDREVRELADVEWTMFRPCMLKDGKALPIKEYGEDGKGLSMFAGVTRASVAEALVSGAADERRWRHQAVVIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y3V8</accession>
    <name>M2Y3V8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_24975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y3V8"/>
    <dbReference type="STRING" id="675120.M2Y3V8"/>
    <dbReference type="eggNOG" id="ENOG502SPGI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_348836_0_0_1"/>
    <dbReference type="OMA" id="RQHEWWI"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="808" mass="91173" checksum="B5DEBBD24055DDFB" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y4E8</accession>
    <name>M2Y4E8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_35483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y4E8"/>
    <dbReference type="STRING" id="675120.M2Y4E8"/>
    <dbReference type="eggNOG" id="ENOG502SGGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1906685_0_0_1"/>
    <dbReference type="OMA" id="WDDATER"/>
    <dbReference type="OrthoDB" id="4525115at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="133" mass="14642" checksum="E8F899D93F30018C" modified="2013-05-01" version="1">MVNWDDSLDKRLLLTIIAVAAPSAIDYKKVAALMGDEYTSGSVQQRYTKKLKKEAEEKFGALGAAGEGEAAAKTHPKKKTPAKKAAGEKRGTDKRKAVKKASEDEEGEKDDEESPSKKVKMERKEESEDEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2YHP1</accession>
    <name>M2YHP1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_29644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YHP1"/>
    <dbReference type="HOGENOM" id="CLU_1777384_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004029873" evidence="1">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="146" mass="16546" checksum="BC7C343553D4FAC5" modified="2013-05-01" version="1">MHILDIPLIISLAFLTLSIAPVDGKDHLLKAIITGCKGRNCEIPERWLQTERIDGDSRCQTFMGPWKSLLGAVNLANHPEKNPSFGNCTLYIWGEKHCKGEQLWQVNDVIHLKKGESCWYSETSGLNTLEQYKGPVRSARIVCRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2YI92</accession>
    <name>M2YI92_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_114624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YI92"/>
    <dbReference type="HOGENOM" id="CLU_3055932_0_0_1"/>
    <dbReference type="OrthoDB" id="89086at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="54" mass="5852" checksum="021E797F1B4350ED" modified="2013-05-01" version="1" fragment="single">SASLALIGDSKGQRLNSTCQVYSRATAYNGACAVICSCYWPDDFPNPLTGRRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJ17</accession>
    <name>M2YJ17_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_75561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJ17"/>
    <dbReference type="HOGENOM" id="CLU_2359704_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="96" mass="11319" checksum="784EC04FBBF895E3" modified="2013-05-01" version="1">MNNPRWACHFHSWRHALSIVLIDHEHRHATPWWPERDSLVVSSHHDSRYSPEGRPELVKSLDHWPFCSTSKENAVENRPGRFAHSHQHRFAGENAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLA0</accession>
    <name>M2YLA0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multifunctional methyltransferase subunit trm112</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eRF1 methyltransferase subunit trm112</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_91933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRM112 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLA0"/>
    <dbReference type="STRING" id="675120.M2YLA0"/>
    <dbReference type="eggNOG" id="KOG1088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086140_0_0_1"/>
    <dbReference type="OMA" id="NMLTSKC"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043528">
        <property type="term" value="C:tRNA (m2G10) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000021">
        <property type="entry name" value="Multifunctional methyltransferase subunit trm112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME39645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="131" mass="14311" checksum="96E3B6389B6C956C" modified="2013-05-01" version="1">MKLLTLNFLTCARKTCKSSPAAFPLHPKEAELEQIELDLNPLFIKNMLPRLDWDAIKTLNQELGLPSLPAETPAAETLAAEDGEPTQTLKDLHTLLMETSIASGKLACGNCGHEYAVKEGIANFLLPSHMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLD0</accession>
    <name>M2YLD0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_28796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLD0"/>
    <dbReference type="HOGENOM" id="CLU_826457_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="336" mass="36155" checksum="42FF8553B67F11C7" modified="2013-05-01" version="1">MNAEWQQQRWTAQKAHDQYRDRKEAEITALCNTLDAKRDLGRSGSSRPPAFRSLFANHGVAKTQREKYIARAYQSLGENVPSVPTYEDIAKQHSQTSETGDTLETPVAEEQQQVPDDLPQTNSEFQTVETAQSSPTRQPKAGANKSSRQALRKVQDYLKTKSKFIKPITIIRYMRKAERVALSLAELRRLYGRCVDAKDLGLARQKTSSRSTASSSVSDDTATTEAAPGETTREASDGIESPVDASSQSSTEAGDLVLESRPSASPAEKTSNPDHESALAVSSDRSIALFGSTECAATATVPLTTSSNSAFAPAIPITGFGKPSTPIPGTIAGSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>M2YM01</accession>
    <name>M2YM01_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_72383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YM01"/>
    <dbReference type="STRING" id="675120.M2YM01"/>
    <dbReference type="eggNOG" id="KOG1486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="OMA" id="DVCDQVH"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="64"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="291"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME42925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="40912" checksum="59114B55E7988424" modified="2013-05-01" version="1">MVNITDKIKEIEDEMSRTQKNKATNYHLGLLKGKLARLRAQLLEPTTAAGGAGAGFDVSKSGDARIALVGFPSVGKSTFLSKVTKTKSEVAAYSFTTLTAIPGVLEYGGAEIQVLDLPGIIEGASEGKGRGRQVISAAKTSDMILMVLDATKRAEQRALLEAELNAVGIRLNEEPPNITIKAKKAGGVKVTFATPSKNLDEKLLYTILKDYKILNADVLVRDENATVDQFIDVIMKDHRTYIKCLYVYNKVDAIGLEHLNKLAREPNTEIMSCELDLGITDVVDRCWDELRLIRVYTKRKGIDPVFSEALIVRNNSTIEDVCDAIHRTIKESFKYALVWGASARHVPQRVGLSHLVADEDVVSIVGTKSGLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2YM72</accession>
    <name>M2YM72_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_88988</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YM72"/>
    <dbReference type="STRING" id="675120.M2YM72"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_1_1"/>
    <dbReference type="OMA" id="NLGTHWT"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="72"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="515" mass="56164" checksum="D9AB70407C8C36CC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2YMB7</accession>
    <name>M2YMB7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_35394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YMB7"/>
    <dbReference type="STRING" id="675120.M2YMB7"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_456434_0_0_1"/>
    <dbReference type="OMA" id="FANDAYI"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF85">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="166"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="601" mass="66587" checksum="497224890C027418" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2YPK5</accession>
    <name>M2YPK5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_89372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YPK5"/>
    <dbReference type="STRING" id="675120.M2YPK5"/>
    <dbReference type="eggNOG" id="ENOG502S3UC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115008_0_0_1"/>
    <dbReference type="OMA" id="VESWVDV"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="135" mass="15202" checksum="12CD8FF280B3A53A" modified="2013-05-01" version="1">MSATSTARPIWNALIRTHHITSRKKVAKLRQAATKEHVFALLRSGSPPGVMYCEGAMANVEKWVAAVQRLRYKEFQLIARPAVIAKDVMHASEADHKTGLYETDSVKDFAAHMDNRGVLAWWRKGMGYIGSEHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBJ2</accession>
    <name>N1PBJ2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBJ2"/>
    <dbReference type="HOGENOM" id="CLU_1378086_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="198" mass="21987" checksum="9722ACAD76885637" modified="2013-06-26" version="1">MCSPERVAKLREQAARPTAVYARPHWVVKWILAFIIFSNLVVTILAGFSINVNRRFGEARGDHDTFITVLMWFAIPVVALAISFVQGIHSGMGCLSAVSVVVAGVFCTLLWVVYACIGMMTTSNNEWCWPWIAPASSGFFLNIAYFSIGADAIRKDKKLRRDVHFAGRSFHKIVEGKPPSYAASEITVWPADEKAMIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBZ1</accession>
    <name>N1PBZ1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_137927</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:12706"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="10"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBZ1"/>
    <dbReference type="STRING" id="675120.N1PBZ1"/>
    <dbReference type="eggNOG" id="KOG1661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055432_0_4_1"/>
    <dbReference type="OMA" id="HMHASAC"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000235">
        <property type="entry name" value="Protein-L-isoaspartate O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME39883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="222" mass="23980" checksum="EA0EBEBA8E41EBDD" modified="2013-06-26" version="1">MAWRSSGTTNASLIDNLSANGLITSERVKNAMKAVDRAHYAPSFPYQDSPQTIGHRATISAPHMHANAAESLLAYLNPGAKVLDVGSGSGYLTHVLAELIQPHGIVVGIDHIQPLVDMAIANTSTSGEGKELLQKGVIRYVKGDGRKGWKEEGPYDAIHVGAAAEGHQQELIEQLKAPGRLFIPVEEGEGQNIWVVEKDDKGEVRKRKEYGVRYVPLTDAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCD3</accession>
    <name>N1PCD3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_74832</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCD3"/>
    <dbReference type="STRING" id="675120.N1PCD3"/>
    <dbReference type="eggNOG" id="KOG2246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022549_0_0_1"/>
    <dbReference type="OMA" id="CATFPKH"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF43">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="204"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME40123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="506" mass="58244" checksum="A8547145D4AEA34D" modified="2013-06-26" version="1">METFASDWRNTKRRPTSQCCIVLLATTIFLSVGLFLFPPAYEVPLRVFSDSGSKASPQQSEAEFYQWQTVTYFKNVNSSAADYTTEQLCQHFPMAKLSEVQPVLKTGHGVIERARQSLSSTSACLDNLLVFSDLSEDLEQYHVIDVIADMPEDLLRSDGQTLPYFEMQKQAMDGTLDGPGMSKGEGWRTDKFKFLPAISRAWRAAPEKSWYVFYEGDTYIVWDTVFRLLEHFDADVPHYLGSPSPGADHGGGLITWFANGGPGYILSRGAMRKLVKHDLDRKTGKWRGSKLAERNWNETLTNCCGDSSLGSALWNEDIELKGLWPLFCPHPLHGVPFSDLYWCQPVLSMHKTEHEDALKLSQFEWDHRDANRPLLYRDLAVGFLNMTDLTRRRDWDNADWDSYRPSPDDQNEPDESPDNCERACAKVEDSDCFQWTYHLQRCKFVRSFRMGGAKAPKVEDGREDHEWSYEDQRYVAGWNSDLIKRWISERPCDEVQWVKPSIERIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCE1</accession>
    <name>N1PCE1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">amh1</name>
        <name evidence="10" type="ORF">DOTSEDRAFT_83854</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCE1"/>
    <dbReference type="STRING" id="675120.N1PCE1"/>
    <dbReference type="eggNOG" id="KOG4245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_2_0_1"/>
    <dbReference type="OMA" id="GFFMDTT"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="9"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME38488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="341" mass="37584" checksum="0577B5B0F0CD3F37" modified="2013-06-26" version="1">MASTMPSKIDVHSHFLPDFYQDACRRHGHSNPDGTVPAWDESSHLALMDELGIQKSIISISSPGTHLIYGNDTLARDLTRKINSFASDLKKRHPSRFGYFASLPIPDIQGSLAEIPKAMEEGADGFVLLTNSHGTYLGDAALDAIFDELNRRKALIFIHPTTPKICPCNAGNVSGTSTEMPTSAAPFGGRVPNPMQEFFFDTARVVSNLFMSGTMRRCPDLRIILPHLGGAFPPLLSRWTGFSELVPGSWEDVNEETVKETLRTQVWFDMAGFSFVSQIVGLMAGVGVGHERLMYGSDYPFTQAGGVKTLLTRMDAGVKELFNERQIEDLYHGNADKLLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCI6</accession>
    <name>N1PCI6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_38017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCI6"/>
    <dbReference type="HOGENOM" id="CLU_1959524_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="128" mass="14435" checksum="F9CA04195947BD1A" modified="2013-06-26" version="1">MPPPASATTYMFVTNNNNKIHYISDVQDATDKKVEIIHAQPREMNLLEKTTGAKRIDTRIGKRTIYISAFNFSGGLMVTVMLQPDGSAYLHDEKLARAVSQKMQYFSIVQCCVLCIFRFLQLLKCPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCP5</accession>
    <name>N1PCP5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Branched-chain-amino-acid transaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_178989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCP5"/>
    <dbReference type="STRING" id="675120.N1PCP5"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_0_1"/>
    <dbReference type="OMA" id="RGWIIEI"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF69">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME40072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="43901" checksum="AE334270EEFB6D2B" modified="2013-06-26" version="1">MTGNVTSPQGDPVSGRLDENGQSAGLLDASRLAYQLTSTPRVIPAPHSPELWAQGEATDHMIMARYNAIEGGWSAPQLVPYGPLSLMPTAAVLHYATECFEGLKLYRGMDGRIRLFRPQHNAQRMRDSAARVSLPDFPAEELVRLIAKLAATDAPRWLPKDRPGTYLYVRPTLIATQPSLAIKKASEALLYIILICFPDFDQPTRGLRLLASGRDRIRAWPGGFGNCKVGANYGPSIVASAAAASQGYDQVLWLFGAEEYVTEAGACNFFAVIQPKDGTGKAQLLTAPLGDAVVLPGVTRTSILETVKTMLATEFEVVERNYSIHELIEAANSGSLSECFVSGTAFFITPVGEIGFGDSKLKVPGLDGSDSLVKRLRDVLWAIMYGEIEHPWAYIVHEHELRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCW0</accession>
    <name>N1PCW0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_29317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCW0"/>
    <dbReference type="HOGENOM" id="CLU_2250064_0_0_1"/>
    <dbReference type="OrthoDB" id="3650886at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="1">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="104" mass="11988" checksum="36744997F8A11273" modified="2013-06-26" version="1">MSLRAVESERISIARPVVAKVETTRFKLEQTQGEDLFALWCMFTDYSKLRVYLPTTWQECLDRKIGIHVAAELSDKAFEIVQHMTDEFARNIPTSVLPQKSQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDK4</accession>
    <name>N1PDK4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_29350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDK4"/>
    <dbReference type="eggNOG" id="ENOG502RDDX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2277400_0_0_1"/>
    <dbReference type="OMA" id="YKDCANI"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108717" description="Hydrophobin" evidence="1">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="10675" checksum="1A8A9F935E2A0637" modified="2013-06-26" version="1">MQFTSLALLSLSAFAFAAPVEEANSLEARGGSSSSGSCSYKNVCCPKSKHSGCKDLPSGKSAPANWDVYNNCVVFGLVNVVVCDILNNDTLNIPITLDLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEA5</accession>
    <name>N1PEA5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEA5"/>
    <dbReference type="HOGENOM" id="CLU_2867630_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="64" mass="7464" checksum="0161EA4129F344C5" modified="2013-06-26" version="1">MLQQQDDRRRRRTYDKRLAMSQPSSPVDEASTHLDTRQVRISDPSNARSSEQSNFELTSRDAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEJ1</accession>
    <name>N1PEJ1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_47051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEJ1"/>
    <dbReference type="STRING" id="675120.N1PEJ1"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001850_0_0_1"/>
    <dbReference type="OMA" id="SPTAHQW"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="373"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="556"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="628"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="691"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="782"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1079"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="628"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="710"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="732"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="792"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME40762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1105" mass="123669" checksum="09AF3E302D137B96" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEQ5</accession>
    <name>N1PEQ5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative glutathione-dependent formaldehyde-activating enzyme</fullName>
            <ecNumber evidence="5">4.4.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">S-(hydroxymethyl)glutathione synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_74216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-(hydroxymethyl)glutathione = glutathione + formaldehyde</text>
            <dbReference type="Rhea" id="RHEA:22488"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="4.4.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (glutathione route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.22" evidence="5"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEQ5"/>
    <dbReference type="STRING" id="675120.N1PEQ5"/>
    <dbReference type="eggNOG" id="ENOG502SKH9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090716_0_0_1"/>
    <dbReference type="OMA" id="MDYIATW"/>
    <dbReference type="OrthoDB" id="3446116at2759"/>
    <dbReference type="UniPathway" id="UPA00562">
        <property type="reaction ID" value="UER00621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051907">
        <property type="term" value="F:S-(hydroxymethyl)glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00723">
        <property type="entry name" value="Formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014185">
        <property type="entry name" value="Formald_GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02820">
        <property type="entry name" value="formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003829">
        <property type="entry name" value="PRK05417.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033318">
        <property type="entry name" value="Formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME40589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="185" mass="20049" checksum="E1D1EB181BEE4D18" modified="2013-06-26" version="1">MVTGLHPLIDHGLQKGGPDFNGGTLECHCLNNRVQVKISSNVLHNHACGCSKCWKPSGALFSVVGVVPKESVSVVANKQKLHIIDPNAAIQRNACKECGVHLYGRIEQPHAFKGLDFIHVELSNEQGWQEPQFAAFVSSIIEQGYDPNKMGDIRSKLKAVGLESYDCLSPGLMDALAAYSAKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEU8</accession>
    <name>N1PEU8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_36602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEU8"/>
    <dbReference type="HOGENOM" id="CLU_1510574_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="178" mass="19877" checksum="783F9B0488D636F0" modified="2013-06-26" version="1">MHLQHSCRLEHSPLRGPAAPFLRRPRSHLYAHRLCYLAESRIAKAQHSSEGTRMLLAHEAVCAILWAHLCADNVEAVRPRSKITLDVALGMLTSHVRPPGKWRQVILQFYEELGVESGDEHIMGLLQDGERDDGVVERVYGITKAKVEIADKTPGQTSKTAAHKYCLRSVLVITASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEY5</accession>
    <name>N1PEY5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_65774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEY5"/>
    <dbReference type="STRING" id="675120.N1PEY5"/>
    <dbReference type="eggNOG" id="KOG3179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_0_2_1"/>
    <dbReference type="OMA" id="VERNAKW"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="255" mass="27708" checksum="AED4E8C07BA72B6C" modified="2013-06-26" version="1">MPSQLRVAVLECDTPLAAIREQYGNYGDILGKLLQRGTTGAGVCDQPEIVISQWDVAGRRAYPRLADIDAIILSEANVDGNAEDAWILDLIMFVQDAYCSNVPIIGVCFGHQVVARALGATVRRSDSYEISATKISLTRAGRGLFEDKQYLVLHQMHRDVVESVPAGCVSIGSTPRCQIHGLYQPHRILTLQGHPEFDQFMVERAAAARAEQGILSDDVAVDGIARAGLPHDGDVVARVMYRFLSLSSGTTSTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF49</accession>
    <name>N1PF49_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_47000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF49"/>
    <dbReference type="STRING" id="675120.N1PF49"/>
    <dbReference type="eggNOG" id="KOG3400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103864_1_0_1"/>
    <dbReference type="OMA" id="KEDDKGW"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000191">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME40704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="144" mass="16269" checksum="35340ED2E589604C" modified="2013-06-26" version="1">MADAQLYEESFAATQVLDQTYDRVHRILGNSHDNATSFTLDVNSELYPIAANESFQMLIASTLNLDGTKDEANQGWRGKRDADPTLADMWDYVCYGKVYRVEDVGEGDQIKVYISFGGLLLCLQGPYKKLSPLKIDYVYLLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFM6</accession>
    <name>N1PFM6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_90991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFM6"/>
    <dbReference type="eggNOG" id="ENOG502QRFY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096561_0_0_1"/>
    <dbReference type="OMA" id="ADWMTKH"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109071" description="EF-hand domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23530" checksum="0C977483C86FD20C" modified="2013-06-26" version="1">MLSSLATITIVSLAVRVQAHGSHAHDPAPSVAADADWATRHMAEEHHIAQFDAGSFFNLHDFDQTNEWTHDDLMKTYGLFHESTNHISKEQKDAAIAEVIKIFDRDLSGTISFAEYTIGEAHGLKLPDLGWGPGHHGDDEYEYEIHHFEKYHDENTKEEDLIHPEDIAHFRMHDEKEAAEERQERQDKMKIVEANIPSKFRRPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFQ3</accession>
    <name>N1PFQ3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfite efflux pump SSU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_136670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Sulphite efflux pump required for the secretion of sulphite as a reducing agent. In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases. Excretion of sulphite mediated by an efflux pump also represents a detoxification pathway for dermatophytes during infection of the epidermal stratum corneum, hair and nails, which are rich in cysteine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFQ3"/>
    <dbReference type="eggNOG" id="ENOG502QT02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030057_6_1_1"/>
    <dbReference type="OMA" id="YIPHCIM"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000004">
        <property type="entry name" value="Malic acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME40420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="410" mass="45773" checksum="26CD08FE3A563E79" modified="2013-06-26" version="1">MSIASEITTATTTCQASKPCDRESRGWRHVVRNFTPSWFSVNMGTGITSILLHNIPYNGHWLQYISYIIFALNVLLFILFLVISILRYTLYPKIFLAMIRHPAQSLFLGTFPMGLATIINMIVFVCVPAWEGNWWKLAWVLWWIDAAFSLGTCFALPFIIMTVHKTELNKMTAAWLLPIVAPIVASATGGIVAEVIPNPQHALITLIVSYVLWGTGVPLAMCVLVVYFLRLTTCQLPPKEVVVSTFLPLGPLGQGSFAIMQLGTVANSLLQRTDTLPVARSLIAGEVLYTAGFMLAIIMWGFGLVWLFFALAAIYTTSRFPFNMGWWGFTFPLGVFTVATTTFGKELPSAFFRVLGTIFSICVTLLWMIVICGTVYRACTREIFVAPCLKDLEKREAEVKFNDSCIEQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG91</accession>
    <name>N1PG91_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_90760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG91"/>
    <dbReference type="STRING" id="675120.N1PG91"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_1_1_1"/>
    <dbReference type="OMA" id="PNGEKWA"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012565193" evidence="5">
        <location>
            <begin position="16"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="6">
        <location>
            <begin position="53"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME40575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="587" mass="68424" checksum="FB83148F82B2FCDE" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGE7</accession>
    <name>N1PGE7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cprA</name>
        <name evidence="24" type="ORF">DOTSEDRAFT_74237</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGE7"/>
    <dbReference type="STRING" id="675120.N1PGE7"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_3_1"/>
    <dbReference type="OMA" id="QKRYQRD"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="65"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="275"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="71"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="450"/>
            <end position="453"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="468"/>
            <end position="470"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="485"/>
            <end position="488"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="613"/>
            <end position="614"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="619"/>
            <end position="623"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="693"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EME40620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="694" mass="77263" checksum="91F7A6E76E142455" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGS4</accession>
    <name>N1PGS4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_81849</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGS4"/>
    <dbReference type="STRING" id="675120.N1PGS4"/>
    <dbReference type="HOGENOM" id="CLU_1348901_0_0_1"/>
    <dbReference type="OMA" id="CMTWVFA"/>
    <dbReference type="OrthoDB" id="10522174at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109750" description="CFEM domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME41577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="203" mass="20310" checksum="B2AEF45600CF4166" modified="2013-06-26" version="1">MTFSKTSALALAFALANALPQTPAGLAIPPSAKNLPNCAVTPLITLLTATGCSQVTTKCLCQDPARTLASIQGSIRTSCTDDAEYEQVWSYVQGCCPTNSSTASTTEAPTSSSSASSSTVVAQGNLTATSTTNGTAIVFSAPIITASNTTSNGTTITTPPTVSATGGSEDTIVPSDGGASSYGTSFAALTVAIGCMTWVFAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGY5</accession>
    <name>N1PGY5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGY5"/>
    <dbReference type="HOGENOM" id="CLU_2158308_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="111" mass="12667" checksum="2D54B2A7CA424131" modified="2013-06-26" version="1">MQPTDARIETMAHRHLVLDHSVIRAGRRQTSLARRRTCRISPNMAFGRMSDQIISWQSSCLDHDMMAAWSAAAYHPGLLWLRPLRPATMRGAAQAHHRFRVSRIVLTGAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI24</accession>
    <name>N1PI24_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_54669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PI24"/>
    <dbReference type="STRING" id="675120.N1PI24"/>
    <dbReference type="eggNOG" id="KOG3009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012201_3_0_1"/>
    <dbReference type="OMA" id="FNCIIAT"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01941">
        <property type="entry name" value="YeiC_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="430"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="743"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME42248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="810" mass="86148" checksum="23DC36813CD171CF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIA8</accession>
    <name>N1PIA8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_27634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIA8"/>
    <dbReference type="HOGENOM" id="CLU_1189903_0_0_1"/>
    <dbReference type="OMA" id="HYKSINC"/>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="233" mass="27265" checksum="9C3A13C10F4A85A8" modified="2013-06-26" version="1">MDLVYINRDAYLRTRLEKMSRRFPTLPYPYILNVFEKAGPNVLKVGEWLEEYESENSSLKKQIQALPQELQDLILDFCVFSSTADGITHIFDDTRPPLGLQINSSVRTRFAFFYYGNDGGFQFSESRNSTLPSAWRCGRWLESLPRQHAQMIQTLRVQHGTMIPTPHYKSINCSGLRKFRELERIVRKSSWELRAGVLYTGLLYWPPVGMGLDRTMWYNVTYRPHGSVTIRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PID3</accession>
    <name>N1PID3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_73250</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PID3"/>
    <dbReference type="STRING" id="675120.N1PID3"/>
    <dbReference type="eggNOG" id="KOG3758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011361_1_0_1"/>
    <dbReference type="OMA" id="HSCLDFF"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="12">
        <location>
            <begin position="62"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="13">
        <location>
            <begin position="206"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME42363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="693" mass="77223" checksum="26FC0A3056C2EB2B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIS1</accession>
    <name>N1PIS1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_89887</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIS1"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OMA" id="QYQWLGS"/>
    <dbReference type="OrthoDB" id="3638056at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="75"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME42508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="523" mass="58303" checksum="A3CF336572F822C3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJS4</accession>
    <name>N1PJS4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_54951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJS4"/>
    <dbReference type="STRING" id="675120.N1PJS4"/>
    <dbReference type="eggNOG" id="ENOG502S3SW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036837_0_0_1"/>
    <dbReference type="OMA" id="HTIDCSH"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="58"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="449" mass="50194" checksum="DE6DF97FD9DA51A5" modified="2013-06-26" version="1">MSESIFDCSEHTITAQHVRGYHRSTARSGGDHLQLAVKQYVPKDNSSPQPGDVTIIACHAASMFKELYEPLFMELHRASKKSSHAFRIRGIWMADVVTHGRSGVLNEGRLGIDYSWGDHARDLLHMINVFRADMPQPLVGFGHSMGGTNIIQLSLLHPGLFTSIMCFEPTLNKERVGMNFVAVYGLTEQRDLWASRDEAVADSYKSPVMKTWDQAVLARWHDCGLRELPTQLYPDAPKAIADRAQAQDTVPVTLTTTKHHQARTYARGVYPPYGDDLSTYRPTRATHPDLSAAEFAKNPSPVPVYRPETNLVFEQLRFLRPSCFYIYGENTTFENAKSQGRADKLEVTGIAEGGSGGVEAGAVADVVLSGIGHFGPMEQPAKVAAVATEWLGNRLQEWKREDDTAAAEWDRVGSKEKAMIDDEWRQWIKKFYGRQARTSNTVSRDKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKU5</accession>
    <name>N1PKU5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_62509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKU5"/>
    <dbReference type="STRING" id="675120.N1PKU5"/>
    <dbReference type="eggNOG" id="KOG1939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002157_0_0_1"/>
    <dbReference type="OMA" id="GTGPQMW"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="255"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="749"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME43976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1277" mass="137327" checksum="D5326AB4BF47958B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLJ8</accession>
    <name>N1PLJ8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLJ8"/>
    <dbReference type="HOGENOM" id="CLU_2413240_0_0_1"/>
    <dbReference type="OrthoDB" id="5415055at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="92" mass="10148" checksum="44420C582476912D" modified="2013-06-26" version="1">MMDVLRLLLSYAQSLELPKVATVEILSSSDASAAEKIVALKAVLSLAAHTLALCTTLAMLWKLEAAIVHLLEVLLWPLMVPLRILRWMVGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLT4</accession>
    <name>N1PLT4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLT4"/>
    <dbReference type="HOGENOM" id="CLU_2306023_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="100" mass="10143" checksum="3CFABA3076F78E3A" modified="2013-06-26" version="1">MADRSTLAAPTPRSTPSSPSSLSKSLNSEPTAEPSLPKSTPSSFARRLASLRAVSADINSSIFCSPHSRSRCPGTRSVAATANSSLSLEAHRASAGSGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMK5</accession>
    <name>N1PMK5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMK5"/>
    <dbReference type="eggNOG" id="ENOG502RF89">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_839443_0_0_1"/>
    <dbReference type="OrthoDB" id="5431248at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="331" mass="35711" checksum="2DB347DE5D9754A5" modified="2013-06-26" version="1">MATIAPRRQEDAGTKKTAVNFSRLRRDTGGSSDYSAEKEVVIQEQSKDSTKPSDLRQPDLEELIQVAYNDDRNVRSIQAFYTSNEGRPLPDEPRFPTDTLNTIASVAELQDTSRHDSLARPDEPVFFNDGSPTSNPMSELPDTSRDVRIETGSISELPDSSPSTPSSASTQLLRDDRSGTPTQAPAPKPAPTVLAKSILRKIPTRTNTSTSSDTISRPSSSSSAGQPLKSILKHTTVEQYSEAAYSEAGEDEGSHHTVSENGTPRIGSVDSSGKWSSSDYDTSQLSEKELKKLEKKGINPALYLEMKAARGAGGKKRFGGLGSLTGNAYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNC7</accession>
    <name>N1PNC7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sec63-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_71659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PNC7"/>
    <dbReference type="eggNOG" id="KOG0951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_1_0_1"/>
    <dbReference type="OMA" id="MNPKEFN"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000005">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="535"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="758"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1386"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME43924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2202" mass="248726" checksum="F034789084F34CBC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNR2</accession>
    <name>N1PNR2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNR2"/>
    <dbReference type="STRING" id="675120.N1PNR2"/>
    <dbReference type="eggNOG" id="ENOG502S6XE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035263_1_1_1"/>
    <dbReference type="OMA" id="WINQNAF"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="271" mass="29773" checksum="C40E8C483CA4FBC4" modified="2013-06-26" version="1">MPQAGLSGSQTVQQSKQHEAVRGFVSGSLNLETALEKFCAPVEKGWKSSKDAEEVEEHLSLSWQSLVAAAATTSFTEASQQKLVDFVMTLQERSVLEKDGQVCQVQGMTVWDDLPTFGWKIRDAWNLTPDEGSDQSSKDQWINLNAFAASLVASAHSQTADTPDLTLFGLWTIRSALEESHKVPDVALAAAAAWFVFAAPTLADLCREEKSFEGKVAKPGSAHSDQDWTGYSMARWESWKQKLDQQENSVSDSTAKQLMEQAVEAVSEVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNV4</accession>
    <name>N1PNV4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_43502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNV4"/>
    <dbReference type="eggNOG" id="ENOG502SZXI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_874435_0_0_1"/>
    <dbReference type="OMA" id="WGTGPVC"/>
    <dbReference type="OrthoDB" id="5076485at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109230" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="318" mass="32230" checksum="B89878FCE9EB4E32" modified="2013-06-26" version="1">MQSFTKRCAVALLTLTTAVTALDGIVAPAEVAAGEEFEVTFQSGNDDNYRVYLAAALAGSNGPTCYLVNSTTLNESVNVTIPASVGPTANYYSIAIADITTGQAATFSNRFNLTGATGEYSDYEDHLGGSPFWSADDLPCSAYQCARQCAQDSYPEDLTETNAYNTMKKCILGCKGVTAAESQTAPAHASSTSGPTATITGMMAVITMSGGSVVTAIETEKEENGSTITEAIIGDATITLNGAARTIGSAHLSLVTKGVAVDDSTTVRFSSTTATMGGSTATDSAASASTSHGAASRMLMAGAAGVAAAGFAGIAFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP64</accession>
    <name>N1PP64_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_62659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP64"/>
    <dbReference type="STRING" id="675120.N1PP64"/>
    <dbReference type="eggNOG" id="ENOG502SQV7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086099_0_0_1"/>
    <dbReference type="OMA" id="ASMIWYV"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109501" evidence="2">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="226" mass="21353" checksum="506CF30D52925D85" modified="2013-06-26" version="1">MSTFSAILLAASLASVALAKTDLSGCTSTDVSSPAGASVAYYVPGTGEICSFLDCGGGRAPPKYSVPGCPQYTGTASYSPSYLAGYGSMTAAPSATSSASQVSGSSSAAVAPVSSSSSAGSMSSNASESASASQAHASEVSSSAVATPSMYTSTGAHTTTVVISTPAAVGGSNGTIGSGTTGSGASSSNGTHGTSPTPSGLYNSGAEKVWIGSAAILGLGALVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPS5</accession>
    <name>N1PPS5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_43773</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPS5"/>
    <dbReference type="STRING" id="675120.N1PPS5"/>
    <dbReference type="ESTHER" id="mycp1-n1pps5">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="OMA" id="ETWAANG"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012429541" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="28"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME45431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="573" mass="62698" checksum="75479F9644694AA2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ68</accession>
    <name>N1PQ68_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_71322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ68"/>
    <dbReference type="STRING" id="675120.N1PQ68"/>
    <dbReference type="eggNOG" id="KOG4044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066901_0_0_1"/>
    <dbReference type="OMA" id="HVCVFQT"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="12"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME45576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="204" mass="22470" checksum="3CC09B35BB5493B1" modified="2013-06-26" version="1">MAGPARRLVRPTLFICDLQEKFRNAIYEYDKVIATTNKLLSASKALDIPVLATTQLRAKLGETCPELGLDSPGGIQTKVHADKSAFSMWTPEVQQAFKELGSEKRECVIVGIESHICVTQTTLDLLREGHKVYVIADGVSSCNPQEIPIALNRLRAEGAVVTSSESFLYECMGDAGIPQFKDMSKLVKEYNGKTKESLQALCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ83</accession>
    <name>N1PQ83_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_71331</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ83"/>
    <dbReference type="STRING" id="675120.N1PQ83"/>
    <dbReference type="eggNOG" id="KOG3084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_0_2_1"/>
    <dbReference type="OMA" id="YSHAKMY"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="196"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME45591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="350" mass="39120" checksum="564DB49AAFA2D4D3" modified="2013-06-26" version="1">MQNGLMDIASTSSSAKYLTFHELNALRDGNGNFAYVGYRDVANWIGRPFEKDEKTQIQEFNPEQHHPGLIFLGLDLEGGCRSDAVQLEHYRGQPYFALDVSGGHYDSFRAAQFEKGRNHAPTRIDLKLDREDSAILSHARSLLDWNTRNLYCSACGGRTLSSSAGHKVVCPPADAGVARKRSCPTRIGLHNQAFPRTDPTVIIAPISYDAKRVLLGRGKRWPENYFSCLSGFVEPGESLEVATRREAFEETGVRLDRVQLHSSQPWPYPSTLLIGAMGQCMEGGENITYPETELEEAKWFELGEIEHALDNGANPMWEPPIKGYAGPRVPPQKLMAHQVLRGVLKLFHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ84</accession>
    <name>N1PQ84_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ84"/>
    <dbReference type="STRING" id="675120.N1PQ84"/>
    <dbReference type="eggNOG" id="ENOG502RDC6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1258766_0_0_1"/>
    <dbReference type="OrthoDB" id="3650836at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="220" mass="24863" checksum="7F6C6416CCC6CCF1" modified="2013-06-26" version="1" fragment="single">MELQDQIEAIVRPWTRTKGKPPFSMAQMVVMCLLLNKPLDKSGILAWLVDRFGYLRKVAVTCLESHTYSSGTSCYNSPGVRGIHLEFPQAFYDFKAPLLSEQHESGEDVFTVAADEGQLYIKPVLARVSEAALRPFPFMRLPTELRLHIYTMVLCLPESGVQIYRWGRTSTTRINVWDREYSQPSIMSGANYANVANYRPLSAGPLQAHLALLLTSKQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQF9</accession>
    <name>N1PQF9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQF9"/>
    <dbReference type="HOGENOM" id="CLU_2469051_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="88" mass="9886" checksum="0CADE1A4DDA8EC35" modified="2013-06-26" version="1">MLCAVPRPGTDEVNDIDTDVYLRDRLNNITFSLAPTVPFNMVNDAGFKMAVAALNMLETRHRGYLLLLRECPCSKVSRVCDWSPSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQI9</accession>
    <name>N1PQI9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Lysophospholipase</fullName>
            <ecNumber evidence="2 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_52875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQI9"/>
    <dbReference type="STRING" id="675120.N1PQI9"/>
    <dbReference type="eggNOG" id="KOG1325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014602_3_0_1"/>
    <dbReference type="OMA" id="YEFHPYE"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005141842" description="Lysophospholipase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="10">
        <location>
            <begin position="44"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME45652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="552" mass="59222" checksum="1BEADC0ABDDD0E5A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR11</accession>
    <name>N1PR11_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_171447</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR11"/>
    <dbReference type="HOGENOM" id="CLU_497844_0_0_1"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110065" description="Rhodopsin domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="9">
        <location>
            <begin position="134"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME45827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="547" mass="59845" checksum="3EA84F1ED596BBF3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRE5</accession>
    <name>N1PRE5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_79114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRE5"/>
    <dbReference type="HOGENOM" id="CLU_1081929_0_0_1"/>
    <dbReference type="OMA" id="MMKHFGL"/>
    <dbReference type="OrthoDB" id="3649027at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="257" mass="29040" checksum="99E08BCF58B46FD0" modified="2013-06-26" version="1">MATKPPSLKSPVELLVLIEDFLTETERSDVLQQWQIEYKCSEGECVPKDHYPNSRLNEWRRMICLDTARSDVLTDEDVDERLNDFIADHTSYIDNHWSRYDSWEDRIGCGPTSIIRQQQDLMMKHFGLDLWLCKTRINGISANKCSAARDTLAYLKLPHGAPHSRSFNLSPDEQGNSCFYFTGSSSIAVAGDLALPQDGQAKTERCLRILGLRPHGCDTEAGSMLSARVIAKAEDERPYTAWPQLTVLTEIRAGTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRT1</accession>
    <name>N1PRT1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_170249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRT1"/>
    <dbReference type="STRING" id="675120.N1PRT1"/>
    <dbReference type="eggNOG" id="KOG0028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_18_1_1"/>
    <dbReference type="OMA" id="EFFMIMK"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000172">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME45080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="251" mass="28037" checksum="88885EC4EE839470" modified="2013-06-26" version="1">MATSHQPFPSRPYTSGLTRGAGASNTPFAGQTTFNAPQQNVGGYGAAGAATSQQQREAQRIERERQERQERERRADEERNALETLSEEQREEVNEAFSLFDLDKDSYIDYHELKVALKALGFEVSKSDLLGLLQQYGVPASSISPTASKVPVPQQPTFSGPSRLLLSHATFVTIAAQKIQERDPKEEIYRAFELFDQDNKGRIELQDLRRVAQELGEGLQEEELQAMIEEFDVRGEGGITREEFLGICLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PS99</accession>
    <name>N1PS99_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_129045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PS99"/>
    <dbReference type="STRING" id="675120.N1PS99"/>
    <dbReference type="eggNOG" id="ENOG502SM98">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013296_0_0_1"/>
    <dbReference type="OMA" id="PRMSKRF"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME45299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="683" mass="75631" checksum="3A5BC08BBA11AF81" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSB4</accession>
    <name>N1PSB4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_70312</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="3 8"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSB4"/>
    <dbReference type="STRING" id="675120.N1PSB4"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="OMA" id="GAYMANI"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109025" description="Mannan endo-1,6-alpha-mannosidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME46272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="480" mass="50935" checksum="121FFC4F154F8451" modified="2013-06-26" version="1">MRVSIASGLGGLLLTAAVTQAIELDVNSTDSLVSTSKAIVGNILGLYRNNNSNGNIPGLFGDPYYWWESGLAFDSLINYWAKSGDESVVQTVQDAMLFQVGPDYNYMPPNQSKTLGNDDQASWALAAMTAAENRFPERDGQNVSWVQLATNVFESQVLRWDETSCGGGLKWQIFSFNNGYDYKNSITQGSFALLAARLARYTGNTTYSYWAQKSVEWSYQIGLISNGTGAVFDGTDDTTNCSQINHLQWTMNAGLLIDAGAYMANITQSGPLADAMFWANALWPTISTASRIFTDQSTSANSSGRAILYEVACAPSNNCNADEKAYRARLARALGNARTLDAQSTYVVNGTGVDSYIQRITTILQTSAIGAAAQCSGGDNGTACGSDWTRGDYDGETGLGQDLSALEVILANIDVKQLRTSHSAQNGTTTSSSGGDRTVTQTSSTGGANSTSAASSSGLLGSSTLTMLLAVLFGAASFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSE0</accession>
    <name>N1PSE0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_71161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSE0"/>
    <dbReference type="HOGENOM" id="CLU_2196897_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="108" mass="12565" checksum="8CFB936DAE4C2DDB" modified="2013-06-26" version="1">MSLLQSSICRRHSRECCYPRELRSHIPSNWTPLLHHRGQSWHRITSGGHTSRHMQPGHCCPVLEKVIDSLRKRLTVPFLWSRALSGFFLTDISRFRCPRCGVADDRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSE5</accession>
    <name>N1PSE5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_71522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSE5"/>
    <dbReference type="STRING" id="675120.N1PSE5"/>
    <dbReference type="eggNOG" id="KOG3041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_0_2_1"/>
    <dbReference type="OMA" id="WHWAAGW"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF26">
        <property type="entry name" value="ADP-RIBOSE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="52"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="208" mass="23127" checksum="F93197E37D6608CB" modified="2013-06-26" version="1">MSSTLQAAKIKRVGPLSPDEAKWTELRKIEWVDPSGKERVWEAAARKTRKESGIDAVAIAPIIRHPSRAPSTLVILQYRPPVDAICVEFPAGLIDAGETPEQAAVRELKEETGYEGKVLDCSPTIVADPGLTNANMQMVTIEVNLKEGDEPPEQHLDDGEYIERVNVPLSELYDKLKALSEEDGKIVDARLFHWALGLHWSRRLNLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSJ5</accession>
    <name>N1PSJ5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deubiquitination-protection protein dph1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_70373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSJ5"/>
    <dbReference type="STRING" id="675120.N1PSJ5"/>
    <dbReference type="eggNOG" id="KOG0010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024293_0_1_1"/>
    <dbReference type="OMA" id="PGMDMFG"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14324">
        <property type="entry name" value="UBA_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000024">
        <property type="entry name" value="Ubiquitin domain-containing protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="403"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME46352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="45784" checksum="1DF6E34FA956BA93" modified="2013-06-26" version="1">MADSNAGGDAAEQQITFNIKSSSDAKHVVTVPMSMTVGDLKQKISTSEYADTTPERQRLIYSGRVLKDGDTIASCKIKDGNTVHLVKSAASNQRQNPASQGGATVPPGAGQPASNVPSNIAAGTGAGNPLAQLTGARYAGFHGLPGADMFGADGGMGAPPNPDQMLRMLDDPNFAQQMNEAMNNPAVLDMLRNNPMIRDNPMARAAIENPEMRRMMLNPDMIRMQMNMQRAMGGGGEGGGAFPMPGQTDTTPATAGGNNERATGTDPLNTDAPSNPFASFGQPGGSGAANPFAALFPAAGGNTNPSDGAQGGGDAASAGAAGQQNPFGNLFGGQGPAGQANPFQQAAQQMMQNPEMMRNMMNMMGGGGGAGGEGAGAGGFSPFGAMGGFGAPAEPQAPADSRPPEERYESQLQSLNDMGFYDFDRNVQALRRSGGSVQGAVEYLLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSN8</accession>
    <name>N1PSN8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_22072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSN8"/>
    <dbReference type="HOGENOM" id="CLU_727665_0_0_1"/>
    <dbReference type="OrthoDB" id="10639275at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="380" mass="44892" checksum="966BAF822917D123" modified="2013-06-26" version="1">MDSSDYILDVKWLPYDWYERLGQRLVRYSSDVEWAEWPSMFPVTCVGRQGFGTEYMVGTLADRELPDQLDVKKAYHYLGKTATFYTIFGGDWSMEWRLNVKTFPLGLIQWTSRIWDMFRKNCREHEKFDARFAIAPWRLARQDDERFDKWLGLGKVPRPVSESDMKQLIEWHVRHCDLLQARATTPITDQDHEHVRELAYFWRFSQKTKPLLAPMTPTFRAVFMLGRNPMTQPPNVLLVLTGHNQDMKSGPATFELIPRSKIVSWRTDSMVEVSLETTIRYLQTLERREEASNDVFRAQNDHRRRAIYQGMVEDTYRDLEAAHRECEISNGIDTGFDVRRALGNGLCLKFGWEALVQDEKWYHVLSSTSTLREIWHLQDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PT42</accession>
    <name>N1PT42_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_34032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PT42"/>
    <dbReference type="HOGENOM" id="CLU_1938111_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="130" mass="15097" checksum="541584EC1048A53B" modified="2013-06-26" version="1">MDLDIVFCIRYHSSHRMVYYLGVGSQWRPDASFADQRADLTRRRHLSPQSARQRRHMVLVGLAKGLETELAIMQYSCERDEWFVLEDVACSGTLLAKPWLCKLSANFTNRVDEDHADPSQFRLIIEHSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTM6</accession>
    <name>N1PTM6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_70694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTM6"/>
    <dbReference type="STRING" id="675120.N1PTM6"/>
    <dbReference type="HOGENOM" id="CLU_122012_0_0_1"/>
    <dbReference type="OMA" id="WYLDIAV"/>
    <dbReference type="OrthoDB" id="3642254at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110149" evidence="1">
        <location>
            <begin position="18"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="152" mass="16229" checksum="86861D8E5F36B600" modified="2013-06-26" version="1">MLASSLLTVAAATLATALPAGVTPAAAPGQFDITNFIFGCTAGCFWYLDIAVHPAVANHPSVPSSVHCQGNLDDNKSFKECDHVTNESKLYAFIGKDDNLLQLKYEVTNSSTSTVYNYYGEKEVYAATSAYADLQTPNFNVTEISGTKSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTS5</accession>
    <name>N1PTS5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EKC/KEOPS complex subunit cgi121</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_78978</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTS5"/>
    <dbReference type="STRING" id="675120.N1PTS5"/>
    <dbReference type="eggNOG" id="KOG4066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065847_1_0_1"/>
    <dbReference type="OMA" id="IVCRMST"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME46851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="182" mass="19907" checksum="D1C4E46F52588D5E" modified="2013-06-26" version="1">METVTLPHLPQHALHVCLFRDVQNAAFLRQQLLDGNTNFEYAFLDASVLLSRKHVLSACFRAVNDLLNARMKSRNVHSEVVFALSPNNNIAESFRRFGLQDGSKDIVAVKVGGHRAAVEAHLLDNIQGTPQTLTDDHLAATRDVARIRKIYRLDAPKKGDAAPLLSAEAEASVLGSMAVKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTT7</accession>
    <name>N1PTT7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTT7"/>
    <dbReference type="HOGENOM" id="CLU_1396283_0_0_1"/>
    <dbReference type="OMA" id="PAYWNDS"/>
    <dbReference type="OrthoDB" id="10381158at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="195" mass="22054" checksum="73DBA3851E6EC5CD" modified="2013-06-26" version="1">MEVHQSPTSPYEGPAYWNDSFVEFANTLGGLQFTTAECSMLADVIKSARRISSASSDRHSAGSSPRDRQISEPDWSTLITQPVRSEQNRIAKQQRRAIDRTKWNRSKAKTKSATAEHNISEAWIRHQEPQSVWSERAVSVKTPEAQSPTEDGCLAPALLHRESLDETEEPQVPDFPLLDFEDDTWLQTFISVPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTY5</accession>
    <name>N1PTY5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_126046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTY5"/>
    <dbReference type="STRING" id="675120.N1PTY5"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064330_1_0_1"/>
    <dbReference type="OMA" id="WDINEPV"/>
    <dbReference type="OrthoDB" id="1722345at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME45879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="264" mass="29454" checksum="212CF2EC10A06EA5" modified="2013-06-26" version="1">MLELSTLPEAENYRKAPGRSLDFAIEHQHAEAVAFLLSRKVKLVEEHIKIATYAQNTEILEILLTYGWDINSQLGPAYPSAMAMVVPDYDLTLWFLEHGADPNTVCDLDLTPLSVAVQGAPIDVIRLLFSRGGSVSFGQLLHYAVRRDIQDQDEVVQLILDKKPLINNVMYQGLECYFLQRAFGLGTPLHEAVERGKLDIARMLLDHGANPLIRDSLGKTARDRATKLQGKVRDAALELLDSYDAFANDESPQFTDDCRATGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU01</accession>
    <name>N1PU01_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_126520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU01"/>
    <dbReference type="STRING" id="675120.N1PU01"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="OMA" id="HTQGVTY"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109089" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="44"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="6">
        <location>
            <begin position="466"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME46862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="67486" checksum="C1DACA88EE10BE5B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU93</accession>
    <name>N1PU93_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_87055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU93"/>
    <dbReference type="HOGENOM" id="CLU_1815740_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="142" mass="15341" checksum="EAEDF5A42E3CEA19" modified="2013-06-26" version="1">MHNSGRSERWACHAPGMTKHTMSMGHRYRTLAGPQMIGICYAAPVEAALFGAYPEVQACSSLGSTAISSTGQRLKGHNNDAPSAMHCTVQYSKSASSNRRMPVWAEQNLIFIAGSLDSGSLAILDRRCLNNTLLCVALKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUQ1</accession>
    <name>N1PUQ1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_70175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUQ1"/>
    <dbReference type="eggNOG" id="KOG4679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_332608_0_0_1"/>
    <dbReference type="OMA" id="DERPWPS"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="468"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="650"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="860" mass="94592" checksum="18F269A687EA93FA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVH9</accession>
    <name>N1PVH9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_166397</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVH9"/>
    <dbReference type="STRING" id="675120.N1PVH9"/>
    <dbReference type="eggNOG" id="KOG2289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022618_0_1_1"/>
    <dbReference type="OMA" id="PIMIKPQ"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="240"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME47382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="505" mass="56044" checksum="61B80574D3209EF3" modified="2013-06-26" version="1">MAANDYYHANANPYLHANPYHDAPVPPLPPQSQSPFGDYAARPSYHSTPAQSYSGASGRIHDDADPFDDGHAIPLSGRKPKHDSTHTVSPILPHEQDDPFVRDVDPRKKKHRTDRGKQGWFKGKITWVCYVLTFVQLVVFLAEIIRNAVLTKSPIEIHPSFNPMIGPSPYVLINMGARYQPCMHNMANVQNSSLAISWPCPNATATTGDGVSCQLSDLCGFSADRNPVVNGSLDQKPEPDQWWRFIVPIFLHAGIIHIGFNLLLQMTLGRDVELQIGSIRFAILYFASGIFGFVLGGNFAATGIASTGCSGSLFGILALTLLDLLYHWRERNSPIKDLLFILVDVIIAFVLGLLPGLDNFSHIGGFLMGLVLGVFLLRSPHAVARRTSQVPPDYTYIPRNEDPQSDGARSFIKSPLGFFKDRRGVWWVWWLVRAAALIAVLIGFILLLKNFYVWKHGCSWCKYLSCLPIKVGGTDWCNVGNLNFTPNNGTAKRDLMNVLEPARLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVQ9</accession>
    <name>N1PVQ9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_69413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVQ9"/>
    <dbReference type="STRING" id="675120.N1PVQ9"/>
    <dbReference type="eggNOG" id="KOG0863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_8_0_1"/>
    <dbReference type="OMA" id="NTQVYGK"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME47467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="251" mass="27725" checksum="A4B090119D661C96" modified="2013-06-26" version="1">MFRNNYDNDSVTFSPQGRIFQVEYASEAVKQGSVVVGIVSKTHAVLVALKRNAEELSSYQRKIIPIDTHCGVALAGLASDARVLSNFMKQQSLASRLTYDRPILLSEITSRIGDRAQTNTQHYGKRPYGVGLLIAGVDAKGPHLFEFQPSGVTQEMVACGIGARSQMARTYLERNLDEFESSSREELIKHALRALKDSLSQDKELTIDNTSLGVAGVDENFKLYEGQEIASWLETTFENKPEGGESMEVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVU7</accession>
    <name>N1PVU7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_31931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVU7"/>
    <dbReference type="STRING" id="675120.N1PVU7"/>
    <dbReference type="eggNOG" id="ENOG502RV5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_520764_0_0_1"/>
    <dbReference type="OMA" id="RIIPPGR"/>
    <dbReference type="OrthoDB" id="5411141at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109375" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME47507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="56367" checksum="F6B9374878051743" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWA6</accession>
    <name>N1PWA6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA repair protein rad5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_77621</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWA6"/>
    <dbReference type="STRING" id="675120.N1PWA6"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_5_1"/>
    <dbReference type="OMA" id="KVEPWSN"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16572">
        <property type="entry name" value="RING-HC_SpRad8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24975">
        <property type="entry name" value="UBA_Rad5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="474"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="867"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="984"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="339"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME47258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1150" mass="128306" checksum="80F9938FE3B0F460" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWC1</accession>
    <name>N1PWC1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_52085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWC1"/>
    <dbReference type="STRING" id="675120.N1PWC1"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038704_1_0_1"/>
    <dbReference type="OMA" id="NLLLTWH"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME46655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="348" mass="37536" checksum="9183188581DEC2B3" modified="2013-06-26" version="1">MAFHFGFASDDGSDDDQVKDAGYGLLNGSAAAAAHTVPVKKHNLDELLATLPERISHSIVKIESPLGRIARIPRRELFDIRLQLLHEDGSSSDQVIDQLEDSDLRAGVYEGGFKTWECSIDLAGLLLDRGPRKDIDELVRCDQVVELGAGSALPTSILFRHAIQNAVTGLTFTLADYNEEVLRLVTLPNMLLTWAVSSGIHNVEISEAENQGDLEITPDLVQRFTADLTSKNITLNLLSGPWSPELADLIPQSAPDMGLVILAAETIYSPASTMAFVDLLAILLNRVKMAKAMIGAKRMYFGVGGSVDGLKAACREKGAVAYEIENHGVPGMEGGIGRALIEVQIYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWF2</accession>
    <name>N1PWF2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_126753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWF2"/>
    <dbReference type="STRING" id="675120.N1PWF2"/>
    <dbReference type="eggNOG" id="KOG3330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087110_0_0_1"/>
    <dbReference type="OMA" id="MVQMQVQ"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME46700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="197" mass="22361" checksum="ACBC270D07039B17" modified="2013-06-26" version="1">MTSKAARLGEEVWKSRVEKINAEVVTLTYGTIVAQLCRDLTLPNTSQRTDYAAVNHELDRMGYNVGLRLVEDFLAKSNTGTCSNFRETAEIISKVGFKIFMNITPLVTNWNQENKAFSLVFEENPLSDFVELPDDGRAQDELWFSNILCGVIRGALEMVQMQVEAHFTSDVLRGNDTTEMRVTLIRFIEDEMPPDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWF5</accession>
    <name>N1PWF5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase family 125 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_124766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWF5"/>
    <dbReference type="STRING" id="675120.N1PWF5"/>
    <dbReference type="eggNOG" id="ENOG502QR7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023537_2_1_1"/>
    <dbReference type="OMA" id="MRGPVIN"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF1">
        <property type="entry name" value="DUF1237 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="57504" checksum="1114E5CFA1BD5546" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWP6</accession>
    <name>N1PWP6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_50823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWP6"/>
    <dbReference type="eggNOG" id="ENOG502R56Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1151776_0_0_1"/>
    <dbReference type="OMA" id="RYPFPHH"/>
    <dbReference type="OrthoDB" id="10553765at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="241" mass="25055" checksum="BE6BB3726A697889" modified="2013-06-26" version="1">MNQMNPLLQHMNIQQSGLPPGRRYHGYGLSPVGPGGPHPAHKINFMAPMANMGLSQNPFGAGRYPFPHHSMPFQGAGGGGGAGISPYSGGPAGPAAGMPGLPGMNPMAAQMGGMLNSMNTMAAMSGMNGMNGMNGMNGMNGMNVSPMLPYMSHQLLELLGVGMNMYDEDDTGVWDGDDEDENGIIMPRKGNNRRRARRARAVGMTPLGPPMGMNMMAMGGMPGMPLPGLSPVGMPMGMPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYY3</accession>
    <name>N1PYY3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_67684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYY3"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011406_1_0_1"/>
    <dbReference type="OMA" id="PLCFLIY"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="345"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME48731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="540" mass="60027" checksum="CD9A45A89EA1B83E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZJ2</accession>
    <name>N1PZJ2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Suppressor of anucleate metulae protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_42141</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZJ2"/>
    <dbReference type="eggNOG" id="ENOG502QTM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014851_0_0_1"/>
    <dbReference type="OMA" id="QDMQYWA"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000003">
        <property type="entry name" value="MYND-type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="12">
        <location>
            <begin position="582"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="274"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="631"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="640"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME47815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="663" mass="73220" checksum="45B00AE387EA4602" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0S0</accession>
    <name>N1Q0S0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_40511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0S0"/>
    <dbReference type="STRING" id="675120.N1Q0S0"/>
    <dbReference type="eggNOG" id="ENOG502SU5W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_556704_0_0_1"/>
    <dbReference type="OMA" id="ENGAYEM"/>
    <dbReference type="OrthoDB" id="5422579at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="56104" checksum="29C91CC0949F1B4A" modified="2013-06-26" version="1">MERLPEELIAAICDHCDHASLKNARAVDHRLLAASTPGVFRHFYMGLFEHSLAHLEKLAKSPIRKHVKKLTIWSDVLPNFTKDAWFKIIDQRPTYSEWMAPYRTADAGLGAREAKAQRVKDYEKLIRRNLTEEQVEQGYAAYLKAVSSQLHWRQYRLMLPFQEYFSMLPNLVEASVKCTTPFAGRRNDWPVWKSLRRSMLVDPDNWLYNTDCQEENYAYLSGHAAVSLLAAVGHRASYADKSEIKSLTVHSSHLDSYRKLLMDARALPELPHMNAIRAYGILDGFVNLTNLHLHVPHATLSSRLGGNSTGSEIMEMLECSRNLQRLDLRYGDDELSPDDDVEQIEALFIRGGSELIWPKIEHLALATNIAGQILIEFIRKHACTLKSLELRDMLIHDVDSAMEQIPRVTTLQHVYMECLWTDADQDSSMDFICVFSRGTDFDDRYEKAVKKYLLGRSDALPKIKRDGGLSTVEDWNNDDLDMADTSEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1D2</accession>
    <name>N1Q1D2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_161978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1D2"/>
    <dbReference type="STRING" id="675120.N1Q1D2"/>
    <dbReference type="eggNOG" id="ENOG502RZXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022899_1_0_1"/>
    <dbReference type="OMA" id="RQYFHKG"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="579"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="677" mass="76041" checksum="3E7D85C270BAEE89" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2E1</accession>
    <name>N1Q2E1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_122360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2E1"/>
    <dbReference type="eggNOG" id="ENOG502S1BM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053359_0_2_1"/>
    <dbReference type="OMA" id="KWRIFTH"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="63"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME48815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="190" mass="20977" checksum="776BF152E86DF900" modified="2013-06-26" version="1">MRACRCQCQRACTSPRKRCGPNRRRGVRANADSSQEPEHEGWFRSLVEKYGSVELENKGSVARDHLALERTFLAWLRTSLSFASIGIAVTQLFRLNTSIAPSDPDAMLSFSASTRLRSVGKPLGATFLGISILILLLGFHRYFESQHYVIRGKFPASRGTIIIVSAVAIALIITSLVVVIAVAPEAFEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2T9</accession>
    <name>N1Q2T9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_67873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2T9"/>
    <dbReference type="STRING" id="675120.N1Q2T9"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035825_2_0_1"/>
    <dbReference type="OMA" id="DGIMMKI"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="190"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME48970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="438" mass="46855" checksum="3161FDD00BDC4CF1" modified="2013-06-26" version="1">MAGVAQCARLSARIASRYASRTVACRGFHVSAQDKAAQNYTMPALSPTMTEGNIASWKLKEGDSFSAGDVILEIETDKATMDVEAQDDGILMKIVKEEGSKGVKVGERIGVTAESGDDISSLELPADNSSPSQGQDDVKGAQRGAEEGSVKEAKQKAPEQQSQPPQPSERSSPGETSRRQGGKAQKQKYPLYPSVEHLLHRNRLSSADVESIPATGPAGRLLKGDVLAYLGKINKEYPAKSSARLEKLGHLDLSNIQTSKKAAAEPEQVKEEATEPGLPKETEVAVPISLSAVIATQKRVHDSLGIFLPLSTFIARASELANHDLPRGKNSKPTADDLFNSVLGLCQVARSSRGHFFPNIAGISPAPLPVRQAKKPDLIDILAPKQPKPKRALPVAPGISAKENVFSVVASTGDESRATEYLERLKLALEQEPGRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q435</accession>
    <name>N1Q435_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_30544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q435"/>
    <dbReference type="HOGENOM" id="CLU_1077782_0_0_1"/>
    <dbReference type="OMA" id="MECLNTY"/>
    <dbReference type="OrthoDB" id="10488530at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME49269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29246" checksum="7E2328ED9C53B064" modified="2013-06-26" version="1">MLQVGNFDGWWKRAEMMLTPKVTSWTRFSARFSKRYIGLDVLGSIPAEAFDHIHALVPVLRKITGTPFRLLDLPAELRVRILETTFEKKQPGDLHAEAPKNGQVVGFMRRSPSRPAACRASRQLRVESIPIFLKGSEFRLVHNMEDRVAPGALRDWSLAHKQLLGSLRRLTVQFRPPMSRRQITVMRIAFVYSHGKGLHIDEREEMSEVSALSDVDNVVARLNAFGQTNGLEGALTTMYFTPPEMWSSCSPDEAQTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4I2</accession>
    <name>N1Q4I2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4I2"/>
    <dbReference type="STRING" id="675120.N1Q4I2"/>
    <dbReference type="eggNOG" id="ENOG502RC08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004908_0_0_1"/>
    <dbReference type="OMA" id="VDYNWTR"/>
    <dbReference type="OrthoDB" id="5589766at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="804"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="881"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1007" mass="111324" checksum="AB0A7D135A1F39A8" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4U5</accession>
    <name>N1Q4U5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4U5"/>
    <dbReference type="HOGENOM" id="CLU_2704766_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="73" mass="8177" checksum="FBCF85A5C7510AA7" modified="2013-06-26" version="1">MQTAMVSLDSTLGGKCLKCEISETTFDILQPPLRSRLPSMKMPTRPRSHTESHFNLASRGFSKTLLMPGILKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5D5</accession>
    <name>N1Q5D5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Caffeine-induced death protein Cid2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_165596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5D5"/>
    <dbReference type="STRING" id="675120.N1Q5D5"/>
    <dbReference type="eggNOG" id="ENOG502S21A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081050_1_0_1"/>
    <dbReference type="OMA" id="QFCFNER"/>
    <dbReference type="OrthoDB" id="5593818at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016805">
        <property type="entry name" value="MIX23_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022603">
        <property type="entry name" value="UCP022603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME50390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22742" checksum="4F8B0E5FD1BC8B11" modified="2013-06-26" version="1">MSRTPTQPTLTPRFCFNQTALRDFLRTSRTAVDDTISQNLNALVTPGSQPWHPSSTTQSQPRPTGRRPIAPSACDSFKNTVLFPSWQSRSDVLNYCTGVATSPDPNDPDHLLREGEDARARERLVDERLDPYSGRYFPREARTEALAGLIRNERMVESIIRARTWGLVGERCENDGQGAEEALDEWRRGNAEGSEVKKILPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>M2WHG4</accession>
    <name>M2WHG4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WHG4"/>
    <dbReference type="eggNOG" id="ENOG502R9KX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1030684_0_0_1"/>
    <dbReference type="OrthoDB" id="3647501at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="270" mass="29794" checksum="D8F5C3B5758A4FF3" modified="2013-05-01" version="1">MATETLTAPAPVANPLRRYSTDPAGTQSYATLNPNRRRTNSINIGSVARQTKRTLPLPSVPEDGQLKADAIRRKTNRESRLSRVFSWSTNWNFAGESTRRTTTFTGDQATLGDDRRFSKLNRRLSSISSYASNVADFLATTEPSHETNFPKGLTFPTSGGFELCVSVYGTVDALEATTMRLMMPMGCKTADFTGSKDYIMALEHICKLKNGDMLCRPTPEIERQYPGAAVILRGTVQDMVFKCYVVGTFPMALITGDTLPGTFEMEAVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>M2WIK5</accession>
    <name>M2WIK5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_83484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WIK5"/>
    <dbReference type="eggNOG" id="ENOG502QYKI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013358_0_0_1"/>
    <dbReference type="OMA" id="QHIGRLM"/>
    <dbReference type="OrthoDB" id="5332870at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="858"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="919"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="954"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME38803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1075" mass="119050" checksum="4218C28BE92D0AD9" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>M2WLU9</accession>
    <name>M2WLU9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WLU9"/>
    <dbReference type="HOGENOM" id="CLU_1835131_0_0_1"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="140" mass="15449" checksum="D33F0AA2A24A623F" modified="2013-05-01" version="1">MEASGAALRVFGTTELPEHVFTSLSLDAYSERSELQRPAPELFVLPRANCDDCTIGRFVLLRIDSDFQPNITGIPSLQRLMELDLTSSRTKGNLKPGAWLLMKIGWSGKVLPPFAVAPMLSARMDRDARVAFHRCGGSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>M2WMA0</accession>
    <name>M2WMA0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_131877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WMA0"/>
    <dbReference type="eggNOG" id="ENOG502R95K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2418980_0_0_1"/>
    <dbReference type="OrthoDB" id="3849578at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10470" checksum="9ED994E551984A75" modified="2013-05-01" version="1" fragment="single">MSLLSLPAELRLRIYDYLPELQHRHETISSYSKLTPSICQVCRTVRYETTPILAANSDFLIDIDGSPSFWHNRISTWLAALVPGSISHVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2XMF3</accession>
    <name>M2XMF3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_95859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XMF3"/>
    <dbReference type="STRING" id="675120.M2XMF3"/>
    <dbReference type="eggNOG" id="KOG3497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143122_2_1_1"/>
    <dbReference type="OMA" id="YKTADAH"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="83" mass="9347" checksum="D4554D3F7F949E6D" modified="2013-05-01" version="1" fragment="single">MLIPIRCFTCGKVIGHLFDKHVELISTEVPDEGATAKSGQSQTKLMDDRVAVDMIGLERYCCRRMILTHVDMVEEMLGYGTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>M2XZY8</accession>
    <name>M2XZY8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_75415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XZY8"/>
    <dbReference type="STRING" id="675120.M2XZY8"/>
    <dbReference type="eggNOG" id="KOG0980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004601_0_0_1"/>
    <dbReference type="OMA" id="FQMSVEM"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17007">
        <property type="entry name" value="ANTH_N_Sla2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000004">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000021">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="814"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="313"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1024"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME38649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1059" mass="119983" checksum="B622FCE7D6C855C8" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIH0</accession>
    <name>M2YIH0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_180554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIH0"/>
    <dbReference type="STRING" id="675120.M2YIH0"/>
    <dbReference type="eggNOG" id="ENOG502SJHR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031811_5_1_1"/>
    <dbReference type="OMA" id="AGCHDTG"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25542">
        <property type="entry name" value="zf-CCCH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="487"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="542"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME38706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="585" mass="66064" checksum="785443230042F14C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIP8</accession>
    <name>M2YIP8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_180684</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIP8"/>
    <dbReference type="STRING" id="675120.M2YIP8"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_5_1"/>
    <dbReference type="OMA" id="HPIMREN"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="152"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="379"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="530"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="547"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME38786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="603" mass="65765" checksum="5C1ADDDFB6E066D2" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2YIX9</accession>
    <name>M2YIX9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_75560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YIX9"/>
    <dbReference type="STRING" id="675120.M2YIX9"/>
    <dbReference type="eggNOG" id="ENOG502RV4V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577492_0_0_1"/>
    <dbReference type="OMA" id="LLELEYW"/>
    <dbReference type="OrthoDB" id="3647231at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="90"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME38890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="473" mass="54320" checksum="5D83AD05D8C8A8E4" modified="2013-05-01" version="1">MDQYLPLTGVPPGYNIHDFGEDVEHSFMSSPDMPTPPAHSPEDDERRYGYGSLDAERRQIRLLQITSQKDDDGNLRCSLTVHTLEATPAYLALSYAWSRPDADCWVSIEANRIQVGKNLLRFLEMIQQCDRFRQTFFWIDAICIDQMNVVERSEQVALMATIYKQAQSVIAWLGPSYGESDVAMNAMRKMPSRSQMPNVWRRSAAGIRRLCHRPYWTRLWVLQELALAKSYTLYCGTKRVPGKLFAEFLDNMKATLMPASFDQSGLAFDAEICLRSPAWSMLKQINTAQRDSLYTQVCQASGLQCRDQRDRVYALLGIAETNLDHIRPDYTAPMIKIVMAVVRNEYIVHPAKDLAAMPRHIAKLCKVLDIDLNSTIEHMSDSEPLSRLGIIQGELHQDRLNFERHSGELSAGLLLSDAITALFLASTHNMPRFVEYWYRETDRTARYELIYRAAQQKWRVIYKLLYGVMIGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJ44</accession>
    <name>M2YJ44_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cercosporin MFS transporter CTB4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cercosporin toxin biosynthesis cluster protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_75587</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">MFS transporter; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin. The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl radical, superoxide, hydrogen peroxide or singlet oxygen upon reaction with oxygen molecules. These reactive oxygen species cause damage to various cellular components including lipids, proteins and nucleic acids. Responsible for secretion and accumulation of cercosporin, but does not play any roles in self-protection against the toxicity of cercosporin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJ44"/>
    <dbReference type="STRING" id="675120.M2YJ44"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_3_1"/>
    <dbReference type="OMA" id="FQGMQTY"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="207"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME38931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="648" mass="72017" checksum="767974719D6DB013" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJG4</accession>
    <name>M2YJG4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_75673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJG4"/>
    <dbReference type="HOGENOM" id="CLU_1461274_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="185" mass="21183" checksum="69CC2A4C5C93AF92" modified="2013-05-01" version="1">MKADEVIWPPAGGHNIDLSCVRPDISVDLRVVFLIKRLPTRVSDRPSAPEMCTVDYRNANELSASRFIDRWDDEFLDGNDMPSPCEQTVLLLLKREQANYPSLVLDASENAITHCGTNGYELHDEYTRNEPDLDKLNVCSDRYINWPREHAPVFRQRMLDNFLDDIWFPHQTSGFVHAVGPNIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJV5</accession>
    <name>M2YJV5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_139187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJV5"/>
    <dbReference type="STRING" id="675120.M2YJV5"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2164340_0_0_1"/>
    <dbReference type="OrthoDB" id="3633556at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="1">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="111" mass="12096" checksum="38F662014346748B" modified="2013-05-01" version="1" fragment="single">DDVINMAAHRPSTAKVEAALLENRESGPIRMHYSRTDVSEAAIIGVADEVTGQAVNIFVPVRSGIVADVNEFTARVRSAIESFAAPKVVHTVDDVRKTRSGKIMRRILRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKD4</accession>
    <name>M2YKD4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="7">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_56743</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="7"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKD4"/>
    <dbReference type="STRING" id="675120.M2YKD4"/>
    <dbReference type="eggNOG" id="KOG2303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011884_2_0_1"/>
    <dbReference type="OMA" id="TSQEVCN"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME39320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="707" mass="79491" checksum="E5532DE54CC01B81" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKV7</accession>
    <name>M2YKV7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_75236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKV7"/>
    <dbReference type="HOGENOM" id="CLU_1875382_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="136" mass="15403" checksum="33F56E455981E24B" modified="2013-05-01" version="1">MLQRTNCPTYDPLPSSNFRIVPTHLTRGPVALANQEARNLLCHPTSPDPRPFLIHSCNDAANEERLWTLDKDNTREVYPNGLLRAANILRHEALAPALEHVVRNSNRVVHDAIAKILKKLDEHPKLEGVRQRSVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLH8</accession>
    <name>M2YLH8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_38855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLH8"/>
    <dbReference type="HOGENOM" id="CLU_2223199_0_0_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="106" mass="11601" checksum="ED03705F0C8D6718" modified="2013-05-01" version="1">MPIATEVDKNVQVQASVNPVDEEEQGPQTDRPLPRDLSPVLLTAFKTSTGARQWVGYQIIPGLVVEFRFQQTMLAAQTCLPKEDVPIGTAIIVFFQTMGGALFVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2YN53</accession>
    <name>M2YN53_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_72696</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YN53"/>
    <dbReference type="STRING" id="675120.M2YN53"/>
    <dbReference type="eggNOG" id="KOG1757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062828_2_1_1"/>
    <dbReference type="OMA" id="MNKKGAP"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140898">
        <property type="term" value="P:CENP-A eviction from euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME43371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="139" mass="14718" checksum="CB7EBEC36E60D6EB" modified="2013-05-01" version="1">MAGGKGKTGGKTGGKAGGAEAGKSQKSHSAKAGLQFPCGRVKRFLKSQTQNKMRVGAKAAVYVTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDTLIRATIAFGGVLPHINRALLLKVEQKKGKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC30</accession>
    <name>N1PC30_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_74734</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with histone H3 and histone H4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ASF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC30"/>
    <dbReference type="STRING" id="675120.N1PC30"/>
    <dbReference type="eggNOG" id="KOG3265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060354_0_2_1"/>
    <dbReference type="OMA" id="CSYDERE"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070775">
        <property type="term" value="C:H3 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010698">
        <property type="term" value="F:acetyltransferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000001">
        <property type="entry name" value="Histone chaperone ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017282">
        <property type="entry name" value="Hist_deposition_Asf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037759">
        <property type="entry name" value="Histone_Asf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="154"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME39963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="284" mass="31261" checksum="DEE19DA5548B3008" modified="2013-06-26" version="1">MASVSLLNVSVRNNPAAFNAPYEFEITFECLEPLQKDLEWKLTYVGSATSSDHDQELDSLLVGPIPVGVNKFVFEADPPNTSRIPASDILGVTVILLSCSYDEREFVRVGYYVNNEYADPAMNEEPPAKPDLDKIRRNILADKPRVTRFQIKWDSEESAPSEFPPEQPDVDQQEDDEEAYAKDELEEEEAQEEGAPLEANGEAAATAKVDEDAEMEGAEGNDKGEESDAGSEDLEAESEDEDDEEEDEVEGTDVDGDAMDTDAAMENGANGHQHAQQPADVMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCF1</accession>
    <name>N1PCF1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_47432</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCF1"/>
    <dbReference type="STRING" id="675120.N1PCF1"/>
    <dbReference type="eggNOG" id="KOG3466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108081_1_2_1"/>
    <dbReference type="OMA" id="KWERNAP"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME39932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="99" mass="11777" checksum="12B21247D3BA9FAE" modified="2013-06-26" version="1">MASKTYVLSLYRRSLKLALDWAVHRYVWRGQAMYIRELFEANKHVTQPRQQRALLEQTEELLEKWKHPDPYRPPTAPGGSKYERNLPCPNLEPPPHMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCP3</accession>
    <name>N1PCP3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_47679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCP3"/>
    <dbReference type="HOGENOM" id="CLU_3068648_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="53" mass="5950" checksum="0E4138C2F91E3C30" modified="2013-06-26" version="1">MTTTTDPMTTKARPTSRGLERAQAIEGTPGIYSRAIAMHFCYCAKRDTEERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCV3</accession>
    <name>N1PCV3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_178736</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCV3"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_2_2_1"/>
    <dbReference type="OMA" id="WMSIRQM"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF57">
        <property type="entry name" value="CINA C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME39889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="49981" checksum="B0C165B62FC49ABE" modified="2013-06-26" version="1">MAKGLAKLSSFYRSCLFQIIIVGLVAFCEPGIWTALNNLGAGGNAKPFLNNAANALTYGLMSIGCFLAGGVTNKITAKWTLFLGAAFYTPYAAGLYCNNRYGNEWFLLLGAALCGIGASLLWASEAAIAVGYPEEATRGRYVGIWMGLRQMGPLVGGAISLALNVATKEKGKVTYTTYLGLVAISALGAPLALLLSQPQDVVRNDGTAIRYMKKTTFGIEAKAIWRQMKNKYMLLLIPVFLAGQFGTTYQGNYLTTYFTVRSRALASFLTAVVGAAANITTGVLLDLPHVSRSFKSKLVYIVVLVALTVAWIWNCIVEIKLSSKTSTPSFDLGDGPFFRSAFAVYMLFKFFYEALQTYIYWLMAGIKGAQGDGDVARTTGILRSWESIGSTVAYAVGATHWSNRNQMVLGFALWGFTVPFTVMAVWGKWNVKEQAVEELGESEGERDLEVQAVSVVGKGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD66</accession>
    <name>N1PD66_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_28179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD66"/>
    <dbReference type="STRING" id="675120.N1PD66"/>
    <dbReference type="eggNOG" id="ENOG502SB89">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_291020_0_0_1"/>
    <dbReference type="OMA" id="HEVKMAS"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="3">
        <location>
            <begin position="465"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="685"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="815"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1050" mass="116615" checksum="04BDD4F0ECEB029D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDA1</accession>
    <name>N1PDA1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_178992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDA1"/>
    <dbReference type="STRING" id="675120.N1PDA1"/>
    <dbReference type="eggNOG" id="ENOG502QT0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017280_0_0_1"/>
    <dbReference type="OMA" id="RNEDSHE"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052032">
        <property type="entry name" value="ATP-dep_AA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585:SF2">
        <property type="entry name" value="ATP-GRASP ENZYME FSQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585">
        <property type="entry name" value="FUMIPYRROLE BIOSYNTHESIS PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13535">
        <property type="entry name" value="ATP-grasp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="375"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME40074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="712" mass="78744" checksum="5F5252C608408732" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDI7</accession>
    <name>N1PDI7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDI7"/>
    <dbReference type="HOGENOM" id="CLU_2497880_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="86" mass="9858" checksum="6BFA30C80C0BA80A" modified="2013-06-26" version="1">MAPTATHPPALSPIHGGTQTRYKAHEEVKRWRLPELTAELRNRTYDLVLPREQDLIIPTRPRSSDISCFPFEAGPTVTTRTRLRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDK9</accession>
    <name>N1PDK9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_140871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDK9"/>
    <dbReference type="STRING" id="675120.N1PDK9"/>
    <dbReference type="eggNOG" id="ENOG502SP7F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1230374_0_0_1"/>
    <dbReference type="OMA" id="GICQATI"/>
    <dbReference type="OrthoDB" id="5410764at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="226" mass="25929" checksum="BCDCCD197FA58124" modified="2013-06-26" version="1">MPPRQDSDTSHRNGDIPIREIVFSCGVCQKLVSDVYSTKESDHGFNSSDHEESGVVVKFWMADCSHTFCAKHLEGGGVPFHQEGQHPLAPCPVCVASNPQRTTPRELFVIRGLSKGEYADEIPDTYLVCPPPSLAVEDAELDPLRFQYSQILRYSKAVTLRWRCEQRKRRILESSISKERKQWRKQEADMKDRIVVLEKGEAKLKKWEQRREMINHYLGLVGKMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDL5</accession>
    <name>N1PDL5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED18</name>
        <name evidence="9" type="ORF">DOTSEDRAFT_29570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDL5"/>
    <dbReference type="STRING" id="675120.N1PDL5"/>
    <dbReference type="eggNOG" id="ENOG502S7EN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084516_0_0_1"/>
    <dbReference type="OMA" id="PVHQHHE"/>
    <dbReference type="OrthoDB" id="5348092at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME38539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="248" mass="28086" checksum="FEC5FF22F03B915F" modified="2013-06-26" version="1">MQEYILYSQIPCEREKQVLAILAGLTGVQPVPIHEQVLIYAQVKAPVVAVSKKVKPKPQQNEGQGLSYHKLWREVITKEDDTQEVGDWKFRAEQTPEAGSMTLISRGVVEHKATEAELERLKQPEWYQFRRHYANSGDRFIFGNVIIRIYRMVVPMEEGVNEGLIEATPLPIEGMKLVDASGSLIVESLVRVATPDKTNNIEDQARKDKPSVTDSAKEELMKFRARMDGAVDLYAPDRLALDTRARNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDM4</accession>
    <name>N1PDM4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DOTSEDRAFT_90700</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDM4"/>
    <dbReference type="STRING" id="675120.N1PDM4"/>
    <dbReference type="eggNOG" id="KOG0337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_5_2_1"/>
    <dbReference type="OMA" id="EDQFGMM"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="212"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="447"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="426"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="717"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="915"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="940"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EME40477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1010" mass="112274" checksum="FBB314B56D9C0584" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PER6</accession>
    <name>N1PER6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_27233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PER6"/>
    <dbReference type="HOGENOM" id="CLU_2306027_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="100" mass="11246" checksum="C1F9D5B4F35C5A13" modified="2013-06-26" version="1">MKIIATNVNKLIYWLTRHRNGGTKVLPPMVLTTRMDYGFMTFDSSNLSRAAHNCRALVNRCDMLVNAHKQAKRPEIELSPGGLRGSRQDECTPSQEGLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF59</accession>
    <name>N1PF59_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ach1</name>
        <name evidence="16" type="ORF">DOTSEDRAFT_74727</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF59"/>
    <dbReference type="STRING" id="675120.N1PF59"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_1"/>
    <dbReference type="OMA" id="KKQGMLG"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="14">
        <location>
            <begin position="66"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="15">
        <location>
            <begin position="582"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME39951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="781" mass="85417" checksum="4E0E73E35C343110" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF64</accession>
    <name>N1PF64_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_27344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF64"/>
    <dbReference type="HOGENOM" id="CLU_2454726_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="89" mass="9929" checksum="18E4F8DDDA4B4800" modified="2013-06-26" version="1">MGDSRFNKSTADYASSAHVGEAFNDPSIYPVTTVVRNGEKRQCHKLTLCAQSKDARVHVCSSEFAEAKQDYIKLEGEDDEQVVKAMLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFA6</accession>
    <name>N1PFA6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFA6"/>
    <dbReference type="HOGENOM" id="CLU_900236_0_0_1"/>
    <dbReference type="OrthoDB" id="5314997at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35225" checksum="A35B355D58FF1E16" modified="2013-06-26" version="1">MDENANFKADCTAQLPPPAWRPFRFLQLPAEMRNLIYGLLLAPDGHIGLLKLQCTAEDRHLKDVVFPDARLRFTCDAEHYILSGCSPQILAVCQQIYGEAKQIMYEENTVCATVAIWTGVLVLNKCLLPDSMLRRLTSLLLACDAAESSTMDSEWFTQLPWKQLQDLTSLRNLRLSLIERESQNDTTRSKKFILEHILERIPASCNVTFVSREGFEDTYVQEVIDETQAQMARRRHVMNVDDVHEVEGRVLEALAKQCMHKQGRKSGHERDYRFPDRSIATVIGKLMPLTKISDVDPHLVLGGTGGRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFH6</accession>
    <name>N1PFH6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_74594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFH6"/>
    <dbReference type="STRING" id="675120.N1PFH6"/>
    <dbReference type="eggNOG" id="KOG0533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052367_2_0_1"/>
    <dbReference type="OMA" id="NEFGPIK"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="77"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME41122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="256" mass="26668" checksum="160B18CC5F787EE3" modified="2013-06-26" version="1">MSGKLDQSLDEIMKDSGATRGPRRGKNGRLPNRKAAQKSKAATTAVIAPSGGIQKKSKAGKPARTPAIPIAPLSGESKINVSNLPRDATEEMIKDYFGDTAGPVKRVIRNYGQDGKFNGSCLVIFSRPDAAAKAARADGTKVDGKPLRVEILVNAKQVVPVKSLAERATAPKNAAKENQKKNQKKDGPKPAVNGEKKAGAKKSGRAGRPKKKTADELDAEMQDYFGGSGEAPAATNGGAQPAVAATNGGDAMDEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFP3</accession>
    <name>N1PFP3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2828 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFP3"/>
    <dbReference type="eggNOG" id="ENOG502QT1I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011744_2_0_1"/>
    <dbReference type="OMA" id="MEEMEIC"/>
    <dbReference type="OrthoDB" id="1149618at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058580">
        <property type="entry name" value="DUF2828"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056690">
        <property type="entry name" value="DUF7788"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011205">
        <property type="entry name" value="UCP015417_vWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373">
        <property type="entry name" value="OS06G0652100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373:SF27">
        <property type="entry name" value="TROVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11443">
        <property type="entry name" value="DUF2828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25043">
        <property type="entry name" value="DUF7788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015417">
        <property type="entry name" value="T31B5_30_vWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2828" evidence="1">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7788" evidence="2">
        <location>
            <begin position="212"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43423" checksum="029243E70A34CAC0" modified="2013-06-26" version="1">MTVARLFAEQLQLDMQRLESGSKQDLEAISMVSKWAPSHKESHDRASRVVSSIAEIMFPFEKVCPNIDPADRMLYLKYARQEYHFRVLPKLRKHLKIVERPITANKFDEIQYDRVPSLTMKAYTSLFARKDFDHFDKYIENVAQGRAQISVATLIPSTLVHDVISPPSVIGRKKGVTDHLVTEKLYATSAKALEGQWNTLVQRMKDSGNLESSIAVCDVSGSMSFPSFPDNTTPMDSSIGLSLLLAEVTKPPFGGALITFSEQPQIMHAGGAEDKQSFSEKVQYIMRADWGGSTNFVAVFEKLILPMAVKHNLKKEDMVQQVFVFSDLQFNSATDDERWTTSYERVQQAYKEAGYDMPHLIFWNLAGGRGVTEYGENIPPKPVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFQ8</accession>
    <name>N1PFQ8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_73766</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFQ8"/>
    <dbReference type="STRING" id="675120.N1PFQ8"/>
    <dbReference type="eggNOG" id="KOG3892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032482_0_0_1"/>
    <dbReference type="OMA" id="PCRKGAH"/>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000065">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="11">
        <location>
            <begin position="66"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="251"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="343"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME41453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="434" mass="47772" checksum="4C236AFB9CC8C7F6" modified="2013-06-26" version="1">MPIAVSPERPRTGVTRLTGGRLVKGDQLVEGDLWISSVTGKILHSQEVFYEHHVVPDEVINIKDKILTPGFIDVQFNGAFGFDFSTIPTEMDTYAKGVKRLNRHLARTGVTSYLPTLPSQLPEVYHKALPYLGPSGHCRNALEGSESLGAHCEGPFISPTKQGIHSLEVLREAHHGFQDFEQCYGHENLSEHRESPITMITAAPEVPGINGLITGVARRGIVFALGHTEATYEQAGEALESGATMITHLFNAMRPLHHRNPGIFGVLGKAAEKKRPYFGIIADGVHLHSTTVKIAWNAHPDGCILVTDAMKTVGQPDGVYDWTNGDRFEKKGTLLTREGSEIIAGSCATLIECVNNFWTWTHASIPEVIKTVTYTPARMLGLEKRKGVLDADADADLLVLDSKEDASGRRVFEVDQVWKFGLKVHDRQDQQFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG79</accession>
    <name>N1PG79_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="17">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DOTSEDRAFT_73886</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Vacuole membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="17"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PG79"/>
    <dbReference type="eggNOG" id="KOG0891">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_7_1_1"/>
    <dbReference type="OMA" id="MRQHSAK"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031137">
        <property type="term" value="P:regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905356">
        <property type="term" value="P:regulation of snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000582">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FAT" evidence="20">
        <location>
            <begin position="1251"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="19">
        <location>
            <begin position="2026"/>
            <end position="2344"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="21">
        <location>
            <begin position="2401"/>
            <end position="2433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2302"/>
            <end position="2372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EME41618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="2433" mass="273912" checksum="AF36ACF6257F7900" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGG5</accession>
    <name>N1PGG5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGG5"/>
    <dbReference type="HOGENOM" id="CLU_2306028_0_0_1"/>
    <dbReference type="OrthoDB" id="10656689at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="100" mass="11388" checksum="80C2A82DD5963C05" modified="2013-06-26" version="1">MGEEIVIMQDEVRCGLHLLLDDKAVVCRCRDNGSWRQLLLIGAHAVFSRCRVVWKIPKRRRQSLRAVMAFKVESIETAGKLVDAVVKGFKANCPECFRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGH9</accession>
    <name>N1PGH9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_64796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGH9"/>
    <dbReference type="STRING" id="675120.N1PGH9"/>
    <dbReference type="eggNOG" id="ENOG502QWJ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054813_0_0_1"/>
    <dbReference type="OMA" id="HNKGAQK"/>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="369" mass="41935" checksum="EEF32446B9BF6DDC" modified="2013-06-26" version="1">MSDHHAHLTNLDRKHRNLSNGREISSSSTLSFTSHLSSLINASSTSNAKSAPARSRPRKEDIFATHNKNSAKRAKRDLEADHAGTFQQKHSTQSDPLDANAWERSKRKMEAKARLYAAMKRGDVQDEDGKYAVDFDAKWAEARVEEREEESDDDDLDSDDGAGDEVEYLDEFGRTRKGTKLDATRAETSRRRNEGAQDADAARPSAPSNVIYGDTIQHEAFNPNTQTWDAMSKLAKKRDKSLTPPPEEHFDSNKEIRTKGTGFFQFSGNAEERKRQMENLEQERAETEMRRQERDGKINVRRAEIEKRREEIRRKSAKRKADEFLKDLGAQMSAQEEQSDAKDASGTGTDMTDRIEAVIQREVLKDDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGL5</accession>
    <name>N1PGL5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_74146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGL5"/>
    <dbReference type="STRING" id="675120.N1PGL5"/>
    <dbReference type="eggNOG" id="ENOG502QU8E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017709_1_1_1"/>
    <dbReference type="OMA" id="FWFFRMR"/>
    <dbReference type="OrthoDB" id="5368598at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose receptor Git3-like N-terminal" evidence="7">
        <location>
            <begin position="75"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="G protein-coupled receptor GPR1/2/3 C-terminal" evidence="8">
        <location>
            <begin position="458"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="593"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="593"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME40471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="80210" checksum="1A983B7C3BE69092" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGM0</accession>
    <name>N1PGM0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_176726</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGM0"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022332_0_2_1"/>
    <dbReference type="OMA" id="IWICLSS"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="46"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME41527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="386" mass="41726" checksum="395F84D3143826F7" modified="2013-06-26" version="1">MASTDDKRVSGDKERELESGSADPTAPPPPPPPSSKSDSKNDLHPAFYIALWISLSASVILFNKWVLHTAKFEFPLFLTTWHMVFATAVTQGLAKFTTVLDSRHKVPMDTQTYIRAILPIGLFFSFSLICGNVAYLYLSVSFIQMLKALNAVVTLLATFAFGITPFDSKKLANVSAIVVGVVVASYGEIQFVMIGFLIQLAGIVFEAVRLVMVQRILSAPEFKMDPLVSLYFYAPACAVINGAFTLFVELPKMSMSDIYSLGIITLIANAAVAFALNVSVVFLIGKTSAVVLTLSGVLKDIMLVVASMVIFGDPVAPLQFFGYSIALAGLVYYKLGADGVKNLGRDAQLALGNMQQTHPARAKAMIFGAVLLVVVGALYFLWPQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGN7</accession>
    <name>N1PGN7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_55697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGN7"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_25_3_1"/>
    <dbReference type="OMA" id="WLPTANI"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="68"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME40496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="589" mass="62682" checksum="E9C3D672BBD718F0" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGS9</accession>
    <name>N1PGS9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_46717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGS9"/>
    <dbReference type="STRING" id="675120.N1PGS9"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072440_3_1_1"/>
    <dbReference type="OMA" id="ACLLCIK"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="15"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME41823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="171" mass="17886" checksum="7FE6576B3858F8CD" modified="2013-06-26" version="1">MSGLVDKLKGQAKALSKGDKIPSSGALKEDNPEQGTVDLSSLPGTNVIVGVPGAFTPPCSSQVPGYVEHADQFAAKGVKGIYIVAVNDVFTTKAWKEKLGANHALVHFLADDTGAFSKAAGLDFDASGLLGNRRSQRYAAIVENGHVKNIFVEDEAPSITVTDAGKVLQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGY6</accession>
    <name>N1PGY6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_37549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGY6"/>
    <dbReference type="STRING" id="675120.N1PGY6"/>
    <dbReference type="eggNOG" id="KOG2938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036838_7_0_1"/>
    <dbReference type="OMA" id="FMVEMVH"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF25">
        <property type="entry name" value="INOSINE_URIDINE-PREFERRING NUCLEOSIDE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109753" description="Inosine/uridine-preferring nucleoside hydrolase domain-containing protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="5">
        <location>
            <begin position="40"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME40795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="391" mass="42320" checksum="0C8FAA15F896FDFA" modified="2013-06-26" version="1">MKSIIALAGLVATSYALPSTKHVSGTKSTANGTISDRPKVILDNDWSTAGFIPILQALKQSWDVVGVVSDTADSWALQTGLHALATLEIGGLDCVPVYRGADFPILNTPAVFQAWETVHGKLAWQGAFAPENLTNEALGNDPTSGDPNRISKSVFEMPYYGYPNTTFASSIAAAEFLVQQVRKYPGDISIYSGGALTNIALAVRIDPTFAKNAKELVIMGGYLDLNLLETTGSVRLADLQSDINLMIDPEGAKMALTADFPNIAIVGNAANQVISTQAFLDEIHRVSNPYTELMYHYYGTGFPFWDETAAAVMLEPSIVKNSTKFYLDVDTSYASPSYGNIHAYQKALAPVAQNLREVNFVIEVDGDALKRRIKEAVQADWGCSGKYVDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH09</accession>
    <name>N1PH09_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH09"/>
    <dbReference type="HOGENOM" id="CLU_2454724_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="89" mass="10502" checksum="D38230C63846DA30" modified="2013-06-26" version="1">MADVKLQSTDPAGRAHIAKQEHDYDCRRRRDERHENRPSATDLLSYRRCCMLLLLVLSSRDRQASTETRLHSSMHTHDKWTTRRPGSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHH0</accession>
    <name>N1PHH0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_56054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHH0"/>
    <dbReference type="STRING" id="675120.N1PHH0"/>
    <dbReference type="eggNOG" id="ENOG502SKHW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043694_1_0_1"/>
    <dbReference type="OMA" id="FIWVKEG"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="375" mass="41162" checksum="1A2A6B6EE0722368" modified="2013-06-26" version="1">MASESTESHCLQIISEALSLEPQDLQDHETWIFLGLGDLLAAATISDLKNQADVDVPEDFFTKCPTVGDVKAFLRAQENATARSVTAIRTSRSKESDKPDHGPEDPWDGIPKPKVPLSVVLQGKPETSSTVIFLFPDGSGAGTSYGTLPPIGENICLIGLNSPFLRQAQSFTCSIERMARLWVGEVRKLQPKGKSYVLGGWSAGGYYAFEVAKLLTAAGEKVERLILIDSPCRLVYEALPEQVVAELTRKGLMGASGERKAPEWLVQHFTSTVISVEKYMPTPLPEEHVPPNVHFIWVKEGLVKSVAESGLDVDLDVKVTRFLLEPRGDLQSEGWEKLLPGARYSYDYMTGNHFQITQPPHVESLGQLLCQVATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHH5</accession>
    <name>N1PHH5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_89563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHH5"/>
    <dbReference type="HOGENOM" id="CLU_2812319_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="67" mass="7467" checksum="3DC1F25F82925A47" modified="2013-06-26" version="1">MPSIMSLLDRTTVRPRGGRTWVVAQHLPDQPPTCHFRHGGFRATDAQNQSFGHDDVQSQAESLVSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHR5</accession>
    <name>N1PHR5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_134794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHR5"/>
    <dbReference type="STRING" id="675120.N1PHR5"/>
    <dbReference type="eggNOG" id="KOG4138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169171_1_0_1"/>
    <dbReference type="OMA" id="CWKRQGN"/>
    <dbReference type="OrthoDB" id="5586401at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039870">
        <property type="entry name" value="Coa4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="3">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME41922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="79" mass="9093" checksum="F03EAAD322FD5D58" modified="2013-06-26" version="1">MSNTEKDQAAAAQTGDADDDEPDDWDKRIFSTGCADENASLNDCFRDKKDWRACKDEMEAFKQCWKRQGNEHRTDSKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHW4</accession>
    <name>N1PHW4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 16">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_89506</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="16">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the LTN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 16"/>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME41987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PHW4"/>
    <dbReference type="eggNOG" id="KOG0803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000471_0_0_1"/>
    <dbReference type="OMA" id="IYGSHWE"/>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="1558"/>
            <end position="1604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME41987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1610" mass="177379" checksum="48C9D473FA2A9AE3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIN9</accession>
    <name>N1PIN9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_134648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIN9"/>
    <dbReference type="STRING" id="675120.N1PIN9"/>
    <dbReference type="eggNOG" id="KOG3203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_1_1_1"/>
    <dbReference type="OMA" id="HKPIYTP"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME41171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="178" mass="19951" checksum="63FF457AFEB04C66" modified="2013-06-26" version="1">MSQYLGQTRLAYSRTWHHLSLSTDPRPLGRLASAIAITLMGKHKPTYDPSTDCGDYIVCTSCSQLHATGKKRFQKKYYSHTTRPGSLKEMTMDKMMDKWGGGEVLRRAVRGMLPKNRLRDDRMARLKCFEGDAHPYGKNVVKIREANGLGGSVGGLPDVKQAWRGKKPTKEPVVEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIS0</accession>
    <name>N1PIS0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NDT80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_73764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIS0"/>
    <dbReference type="STRING" id="675120.N1PIS0"/>
    <dbReference type="eggNOG" id="ENOG502SAHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019472_2_0_1"/>
    <dbReference type="OMA" id="MRYIMTD"/>
    <dbReference type="OrthoDB" id="4117572at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000007">
        <property type="entry name" value="p53-like transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF1">
        <property type="entry name" value="PROTEIN PACG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="91"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="91"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="524"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME41450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="550" mass="60264" checksum="B88C0D38E25646AC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIW1</accession>
    <name>N1PIW1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_89751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIW1"/>
    <dbReference type="STRING" id="675120.N1PIW1"/>
    <dbReference type="eggNOG" id="ENOG502QRXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033165_0_0_1"/>
    <dbReference type="OMA" id="GWGYMLM"/>
    <dbReference type="OrthoDB" id="2014654at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000191">
        <property type="entry name" value="Retrograde regulation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050273">
        <property type="entry name" value="GppA/Ppx_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057512">
        <property type="entry name" value="RTG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005:SF0">
        <property type="entry name" value="RETROGRADE REGULATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23566">
        <property type="entry name" value="RTG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx/GppA phosphatase N-terminal" evidence="1">
        <location>
            <begin position="38"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="RTG2 C-terminal" evidence="2">
        <location>
            <begin position="353"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="581" mass="62927" checksum="7FE368EDD025ED4C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJC3</accession>
    <name>N1PJC3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_73378</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJC3"/>
    <dbReference type="STRING" id="675120.N1PJC3"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008830_0_0_1"/>
    <dbReference type="OMA" id="DMSLHHN"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000606">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000758">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF127">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="193"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="295"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="542"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="638"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="295"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="416"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="647"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME42512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="710" mass="77143" checksum="B66182625F1020EA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJY6</accession>
    <name>N1PJY6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_26984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJY6"/>
    <dbReference type="HOGENOM" id="CLU_2306026_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="100" mass="10510" checksum="5DA4CAD1C0320004" modified="2013-06-26" version="1">MIVSELKAASKAHEAGNVSRHRNNSAKQIPRLTTARGGEDLTVVEGTAKAKAEQEASKDMGPRTKDCATYGGIGDGSEVVLDGNQSLSASMRVEDTCAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKK1</accession>
    <name>N1PKK1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_44308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKK1"/>
    <dbReference type="STRING" id="675120.N1PKK1"/>
    <dbReference type="eggNOG" id="KOG4628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031409_1_0_1"/>
    <dbReference type="OMA" id="TKYKQWK"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000539">
        <property type="entry name" value="Ring finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF434">
        <property type="entry name" value="GB|AAD18119.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="244"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME44022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="419" mass="45785" checksum="AAF3E9BF0E7C3405" modified="2013-06-26" version="1">MSATTTTSTAPSATSTGNQGGGGGGGGGPTSSPLLFFVALGFGVVFTNLWIIVGVKYCFRYNQRNRAARALNENGEPIDLGQMPHQRRRRRDKKLMSMEEVNERFPLTKYKTWQSSREASGLPAEGGVTAPASRAATLKDEEGTIDTTLPRPSTDMARPQTALSIAQQDHANANATIHPRISTEGGATSSGEKHTEKTMIERTETADTLKDGSASVASGLDEDDDDPIRTAAPPEMLAAPGDSCAICLDTLDDDDDVRGLTCGHAFHGSCVDPWLTSRRACCPLCKADYYVPKTRNEEEPTRNGRTPLQQPANVWIGGLGRPFTPRTLFAPRFFMSDTNQQNLYNPTPAHQERTRREQDAFYAEPATERQGEETPPRTWRSRLPTISMPRLGRRARQQQGEQHGPVEVTPTQLESGTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLF2</accession>
    <name>N1PLF2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_71986</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLF2"/>
    <dbReference type="STRING" id="675120.N1PLF2"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030577_0_0_1"/>
    <dbReference type="OMA" id="NHVKRAT"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03002">
        <property type="entry name" value="PDI_a_MPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109945" description="protein disulfide-isomerase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME44332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="534" mass="57211" checksum="453E489DDF78D3EE" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLT6</accession>
    <name>N1PLT6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLT6"/>
    <dbReference type="STRING" id="675120.N1PLT6"/>
    <dbReference type="HOGENOM" id="CLU_1454377_0_0_1"/>
    <dbReference type="OrthoDB" id="272681at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21818" checksum="EBC07C8DCA55FE1C" modified="2013-06-26" version="1">MAEEIIRAYPDAKIILTIREDEERWLRSFLDTLWYNYTTWSHWFLRNVDSQWREQGAFLSPFYERFHGDPVAHGLRVYREHKAVVQRVTEPKERLLVYDVNQGWGPLCAFLQQHVPTENFPKTNGVDDHRALFGAGRRKALKAWASNAMLKRGLPVILTAVLWMFRSRVVSSIRAGLAQIGLRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM30</accession>
    <name>N1PM30_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF718 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_129465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM30"/>
    <dbReference type="STRING" id="675120.N1PM30"/>
    <dbReference type="eggNOG" id="ENOG502S4QF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100689_1_0_1"/>
    <dbReference type="OMA" id="HAKVWPE"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389:SF2">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13513" checksum="C3AB1F95F05BC227" modified="2013-06-26" version="1">MPESKRVAQIVRIKRESISAYKECHAAVWPAVLKQIKDCNISDYSIFLDEDALILYATMKYGGSDFERDMEKMRANPEVRKWWAMTDEMQESLVAGSSGSTDARGWWKGLEEVFRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PML6</accession>
    <name>N1PML6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PML6"/>
    <dbReference type="HOGENOM" id="CLU_1004815_0_0_1"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40257">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40257:SF1">
        <property type="entry name" value="DUF1330 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30160" checksum="155ADC038A4AC5DC" modified="2013-06-26" version="1">MPRCTIHLISLVKGIPPEKVINQLLADHAPVLLKGIPHGWVHQPHHLNKSELLSQEWDLFMMLPSNLQLSFRSDSVPAHVSVNVTLGESQYEKLLGHADELPRPSSNTPPLPVEWPGTGSITQDAIVDTQPGALKPGELHLDSGMAKFLSSALPTAAANAPVSFFNLFKYRNNDRSVHDSYMDGFKRSFGSAAGATVKFMGPVASDMSYNAGDGSAASDGTGGERWDDANLVQYDSVWHYAYMLSTTEYKGLNQQKVAGLMDTCILLVSEIELARST</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNC5</accession>
    <name>N1PNC5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_33524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNC5"/>
    <dbReference type="HOGENOM" id="CLU_1586436_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="168" mass="18882" checksum="3D5E243B467C1ACF" modified="2013-06-26" version="1">MVDVQFKKIKQLQAEVQVANDHLTAQLADKDEDHKKAEEALRNKYEAQCAKLEDELGVLRKEIREKKALKASPDVRPSRLQQQLGTEQQSVGQLRRELYAEKTTLAATSGVKEQALDEVRKLRGKLEESAGDCRGPKKQKSALKAKISKLQQGMSAGDVVKDILPMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNC9</accession>
    <name>N1PNC9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DOTSEDRAFT_53161</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNC9"/>
    <dbReference type="STRING" id="675120.N1PNC9"/>
    <dbReference type="eggNOG" id="KOG2403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_1_1"/>
    <dbReference type="OMA" id="METGTLH"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="22">
        <location>
            <begin position="76"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="23">
        <location>
            <begin position="527"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="81"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="471"/>
            <end position="472"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EME43895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="663" mass="72612" checksum="A527B2FEFF8E30DC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNR8</accession>
    <name>N1PNR8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Purine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_71765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNR8"/>
    <dbReference type="STRING" id="675120.N1PNR8"/>
    <dbReference type="eggNOG" id="ENOG502QQD4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017959_7_0_1"/>
    <dbReference type="OMA" id="GLGFDWN"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME44069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="63607" checksum="B862923268587395" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP02</accession>
    <name>N1PP02_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_34673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP02"/>
    <dbReference type="STRING" id="675120.N1PP02"/>
    <dbReference type="eggNOG" id="KOG0747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_1"/>
    <dbReference type="OMA" id="KLIPLMC"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000304">
        <property type="entry name" value="UDP-glucose 4,6-dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="46"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME44169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="444" mass="49111" checksum="6060DBA08E10612B" modified="2013-06-26" version="1">MAADGAWAAGGSLDSRFFADDGIWRDAPLLTGRGSFEPLPDVRNIMVTGGEGFIASWLVRHLVTKYPDNYNVVCFDKLDYCSSLNNSRMLADRPNFKFFHGELTKPADVLSCLRKYDIDTVFHLAAQSHVDLSFGNSYAFTMNNVYGTHVLLESAKEVGTIKRFYHISTDEVYGGAAADAAGLAEHSVLAPTNPYSASKAAAEMYVTAYVHSFRLPVVMIRLNNVYGPHQFPEKIIPKFISLLQRERPLYIHGDGQNTRHYLYAGDAADAFDTILHKGQIGQVYNVDSRKEISNLELAETLLSTFGVSDTQGMIQYTKDRPFNDLRYPVDGSKLRHLGWVQKVGFEEGLRVCVDWYGKYSGWWGDIESILSPFPVVNKQENSLDVAGDGNDSTPNKRSLQANVGAEDAAPLGSGNGRLYDPIANGVKAMNGVPKKRKASVLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPL2</accession>
    <name>N1PPL2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_72012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPL2"/>
    <dbReference type="STRING" id="675120.N1PPL2"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_386851_0_0_1"/>
    <dbReference type="OMA" id="DLEAKNW"/>
    <dbReference type="OrthoDB" id="3640777at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="120"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="714" mass="80593" checksum="387AC93EBB607217" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPV8</accession>
    <name>N1PPV8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aromatic-L-amino-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_71215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPV8"/>
    <dbReference type="STRING" id="675120.N1PPV8"/>
    <dbReference type="eggNOG" id="KOG0628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011856_3_1_1"/>
    <dbReference type="OMA" id="NPGFNWS"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="460"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME45422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="61602" checksum="2A2D91FE10B60670" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPW2</accession>
    <name>N1PPW2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_127624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPW2"/>
    <dbReference type="STRING" id="675120.N1PPW2"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_1"/>
    <dbReference type="OMA" id="PVVFECV"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="8"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME44973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="360" mass="38131" checksum="CEFDBB1E5A54745F" modified="2013-06-26" version="1">MRAARYYGKEDIRIKDDIPVPSCGDDQVLIEPAFVGICGTDLHEYLGGPNFSPQTPHPVTKEQIPITIGHEFSGVIKTLGKNVQGLHPGQKVAVQPTIFCGACGACKVNAENACPNGGFVGLSGGGGGMSEAVVVTSEAIFPLPENVDLDIGALVEPLAVAWHAVDASPIASLKGPKCLVLGGGPIGLAVVQVLLGRGAEMVICAEVAKRRQEFAKEFGAHHVLDPSKVDVASQSLELCGGVNGPDLVFDCAGVPKSLQTACESVRSRGTVVNVAIWEKEVPFNPNWLVFREASYKAVLGYQKKDFQGVVDALGAGKLKPQSMITSKIKMDRLVDDGYLALINEKDKHVKILVDVQGSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPX8</accession>
    <name>N1PPX8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHF5-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_61966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPX8"/>
    <dbReference type="STRING" id="675120.N1PPX8"/>
    <dbReference type="eggNOG" id="KOG1705">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110369_1_1_1"/>
    <dbReference type="OMA" id="AYYCWEC"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12224" checksum="BAF4214FCDA2923A" modified="2013-06-26" version="1">MSRHHPDLVMCRKTAGISIGRLCDKCDGKCPVCDSYVRPTTLVRICDECAFGNYQNKCVVCGGEGISDAFYCFECTRLEKDRDGCPKIINLGSSRTDLFYQKKNFRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQB4</accession>
    <name>N1PQB4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="1">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_72127</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="1"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQB4"/>
    <dbReference type="STRING" id="675120.N1PQB4"/>
    <dbReference type="eggNOG" id="KOG0571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_2_2_1"/>
    <dbReference type="OMA" id="GIVCAFD"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070981">
        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="5 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="2"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="392"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME44570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="605" mass="68221" checksum="4CBA24ABE9B2DD59" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQB7</accession>
    <name>N1PQB7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EngB-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_128494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQB7"/>
    <dbReference type="STRING" id="675120.N1PQB7"/>
    <dbReference type="eggNOG" id="KOG2486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033732_4_1_1"/>
    <dbReference type="OMA" id="LCYYWDT"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052279">
        <property type="entry name" value="EngB_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498:SF1">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="6">
        <location>
            <begin position="105"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME45592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="374" mass="40778" checksum="43C7119C7098D011" modified="2013-06-26" version="1">MSLLLRLPPALRREAYNHAAASAITRRHLTSSAHSDIAEDGVSINLATPTISKSLLTLSPAILNSYDISTPPSTTDLRHAGAFFTRLPPTLLFSAPYFRSFPPSPFSEVAFLGRSNVGKSSLLNALFGRPNEKPAHVSKRPGKTRTMNGYGIGGEGMVGAKGKSGEKVDAANASDPTWKRFGRGGLVIVDMPGYGSGSRETWGAEIMKYLQNRKQLRRTYVLVDTEHGLKASDISLLVYLRQEGVPHQIVLSKVDKLLYPEPKAPSPQKLHNRLLKLQDTCAELKEKLNEAAAGAGGRSAMHDLLCCSAEKSIDEKGRNRRIGIDELRWSVLTACGLENKPLSQSKIQKERNKGRVEGPAETAYASSAYMPMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQK2</accession>
    <name>N1PQK2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_72233</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQK2"/>
    <dbReference type="STRING" id="675120.N1PQK2"/>
    <dbReference type="eggNOG" id="ENOG502RF2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013691_3_0_1"/>
    <dbReference type="OMA" id="NGYCTHV"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110018" description="tyrosinase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME44704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="673" mass="71787" checksum="6DAF32B4DF2296AC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQM0</accession>
    <name>N1PQM0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQM0"/>
    <dbReference type="STRING" id="675120.N1PQM0"/>
    <dbReference type="HOGENOM" id="CLU_1340338_0_0_1"/>
    <dbReference type="OMA" id="HARPVIM"/>
    <dbReference type="OrthoDB" id="5337308at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108964" evidence="1">
        <location>
            <begin position="31"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="205" mass="23403" checksum="F4362FAE3ABD58C9" modified="2013-06-26" version="1" fragment="single">MADLVRFRTHARPVIMVVLLLAALLCFMNAVKQKAAFSNRAHQRQLDLYTGDSGFGRTFSDHNSSYSRRLRARDPYDGWQALSMASDGEYVAAKERGEVLLCWLEHPDEVPPHTAISPWDSYDELKEWGWEDKSQRHNGGEGDPGLKQIFDGSELDVWTNEDTKVVMEHTGEHPAEHGISYPPTGAKYENYMYPRHGLLVAEYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR22</accession>
    <name>N1PR22_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_169901</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR22"/>
    <dbReference type="STRING" id="675120.N1PR22"/>
    <dbReference type="eggNOG" id="KOG2609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051065_0_1_1"/>
    <dbReference type="OMA" id="RRRMHND"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME44869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="307" mass="34996" checksum="7907F725B9E5F504" modified="2013-06-26" version="1">MPATRKRKGSPSLGETEDSAKRRFAETEEVAASEAPEPQEEQWEPQPSPAEAAQPLPPANDRAARFAALRARNAASRKSNLAETKNEVHRSTVDPSQLTSLNRKKDIAQHKLLKAEVEESGADFERKRAWDWTIEESERWDEKVAQKKANKDKNAFQDYNQEAGKVYERQLGQMQKSGFDERMQAYEKDKRDAIDRAVLSGGLEVVETADGELIAVDKDGSFYSTGDSSTFTNNRPTKDAVDRLVDDIKKAEEMRLKKRRERGRPDEDGQDVTYINEKNKQFNMKLARFYNKYTADIRESFERGTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>N1PR98</accession>
    <name>N1PR98_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_70813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PR98"/>
    <dbReference type="STRING" id="675120.N1PR98"/>
    <dbReference type="eggNOG" id="KOG0704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044516_2_0_1"/>
    <dbReference type="OMA" id="MSKLWEV"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME44890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="394" mass="41845" checksum="4DECC113C0981299" modified="2013-06-26" version="1">MSKLWEVDPQTKAKLLEISKVNENNRCVDCGAPSPQWASPKFGIFFCLACSGIHRSLGVHISFVRSVTMDAFKTGEVKKMEMGGNKPWKDFFDAHSSNSLAGRDFESCTISERYDSDAGEEWKDRLTAKVEGTEYVPGSSAKAAPKKATVESAANTPAGSGRNTPLSNVRSPPQRAATPSQKAQNEAYFAKMGAANENRPDHLAPNQGGRYGGFGSSPMPTNNSSGSAPALDDFQKDPVAALTKGFGWLSSTVSKQAASVNKAYIQPGMQNIQSGDLAAQARAAAMQFGTVAQQGVKGVGDQFNKFVDPEHQPSAAGQRGAAPEKKDFWDSFGQDPNGPPKEKKDFWDDFAAAGETATQQKAKSSNLGTSAMKTSNNAGAGAAGKKDDGGWGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRC2</accession>
    <name>N1PRC2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_70827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PRC2"/>
    <dbReference type="eggNOG" id="KOG1809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000135_0_0_1"/>
    <dbReference type="OMA" id="SGWRPIR"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017148">
        <property type="entry name" value="VPS13_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037235">
        <property type="entry name" value="VPS13_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="6">
        <location>
            <begin position="1107"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="7">
        <location>
            <begin position="1977"/>
            <end position="2553"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="8">
        <location>
            <begin position="3075"/>
            <end position="3123"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="8">
        <location>
            <begin position="3149"/>
            <end position="3208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="839"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1062"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1381"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1575"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1763"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1955"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3124"/>
            <end position="3144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="839"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="878"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1406"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1575"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1596"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1776"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1955"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3130"/>
            <end position="3141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME44915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3233" mass="363323" checksum="25CF953F958E1A4D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRE0</accession>
    <name>N1PRE0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="3 9">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_70851</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="9">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="3 9"/>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRE0"/>
    <dbReference type="STRING" id="675120.N1PRE0"/>
    <dbReference type="eggNOG" id="ENOG502S7VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031304_0_0_1"/>
    <dbReference type="OMA" id="WYTNSES"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME44935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="202" mass="22869" checksum="3EC6A4324B1815F5" modified="2013-06-26" version="1" fragment="single">MQSISALLVTDMTLKEGEIGMQLKPKWLAQSPTAPANSKRCRTCALRAYRAYERIRTATDAQETCPLDLVNTNIDERRKVVYAITTDRDIREFLLGQALALFEQLRICQMKLDQYGALRVADQGPVSNLCKAMTLRDCSLFVKLSGNSIDARLGDLDLKQAEKLPRWQAIESTLVNEGWYTNTEREDVRGRERICLLSRSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRX7</accession>
    <name>N1PRX7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_87980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRX7"/>
    <dbReference type="STRING" id="675120.N1PRX7"/>
    <dbReference type="eggNOG" id="ENOG502SJFI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056960_1_0_1"/>
    <dbReference type="OMA" id="DMPIDIN"/>
    <dbReference type="OrthoDB" id="3937708at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109012" evidence="1">
        <location>
            <begin position="19"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="390" mass="41209" checksum="2D19C120E061FA84" modified="2013-06-26" version="1">MRPLVLSTAAALVCSAAAQNCTTCQSFGVDIVGGGTYFQNIASTDPFTALQEFEGCQDDSSYNLLVDPSGTQYQCNNTPMTPADTQELVTCPIDENQLVSGNWQLIIISNNGQCDPIDYVRQFSLEVGEQVTTTVGPTITLISTTTPISSTVITQVSSITVSAPAVTTTGSASDALFTITRYPLPSFVWQTRAIFTKTKVSQVPNVVATKTITTTAPCGSPIGNPNSAVAAAATARRQVPDAWNKVQAVKILGETIHAWQDVLDPPSNNPVPTLQARSGSLESKRQLVQVRQIQKRGPDAPTITVTDTSSTATATSTITASTQYVTGTTTKYQTTTTTGVVTVKGRQQLLTTITAKAPTVTNVFLLPVTTIMVTRTQDVTITVTSAVSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSM1</accession>
    <name>N1PSM1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_170804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSM1"/>
    <dbReference type="eggNOG" id="ENOG502RNN9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1643667_0_0_1"/>
    <dbReference type="OrthoDB" id="5429740at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="161" mass="17874" checksum="171A68A96C345959" modified="2013-06-26" version="1">MSHSAGITRAAKTAAILFPASCRADHGRMLWPCPDTSNLSAGLLTLRTTPVLDSHGTMEKSSLCLCFPCILYYLDGYIYPRAEHQFYPVLLRKGFTRDEQLAIAEEWYWVAFERETAVKDYMNGYVTFTDGCTWRPPPLLQPSYASTPGASSSSSRSTTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSW5</accession>
    <name>N1PSW5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_70531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSW5"/>
    <dbReference type="STRING" id="675120.N1PSW5"/>
    <dbReference type="eggNOG" id="ENOG502R2TQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040551_1_1_1"/>
    <dbReference type="OMA" id="AMIAMSH"/>
    <dbReference type="OrthoDB" id="1705416at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657">
        <property type="entry name" value="TRYPTOPHAN RNA-BINDING ATTENUATOR PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="364" mass="38664" checksum="1958926BADCED967" modified="2013-06-26" version="1">MASQQGQYFPPPPSSGGDQDRQQSFTPPPTNHQTYFAPPPPQPQQIQSQQQFAPPPTFAPPPSVSPLGPEHNTTQEKALPYYPGPPSLTEVSESQKEAAQSMEPLASPRLASFNANRQSSMPGGAPPPGHFTGAQATADDVGTFNGGSYRISHRDSNTIVTIQLAMGCPLTVKPGAMIAMSPTITVKGEFKFSMKKLIARGHMSHSHFTGPGELLLAPSALGDITNIRLSGSEHWNVGKDAFLAATQGVTKDYVSQNLSKAIFSGEGLFIYKLAGVGICWIQSLGAIIRKDLRENEKYIVDNGHLVAWNCGYTLERVASGGIVSNFAAGEGLVCKFQGPGTVFLQTRNPAQFAAYMAAHGAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUY6</accession>
    <name>N1PUY6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 31 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_70228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUY6"/>
    <dbReference type="STRING" id="675120.N1PUY6"/>
    <dbReference type="eggNOG" id="KOG1065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017110_1_0_1"/>
    <dbReference type="OMA" id="FMTDFGE"/>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06594">
        <property type="entry name" value="GH31_glucosidase_YihQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052990">
        <property type="entry name" value="Sulfoquinovosidase_GH31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044112">
        <property type="entry name" value="YihQ_TIM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46959">
        <property type="entry name" value="SULFOQUINOVOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46959:SF2">
        <property type="entry name" value="SULFOQUINOVOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110197" evidence="3">
        <location>
            <begin position="20"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="4">
        <location>
            <begin position="347"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="657"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME46160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="768" mass="85017" checksum="301648AFAF7BFDA7" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVK3</accession>
    <name>N1PVK3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_69448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVK3"/>
    <dbReference type="STRING" id="675120.N1PVK3"/>
    <dbReference type="eggNOG" id="ENOG502S756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091798_1_0_1"/>
    <dbReference type="OMA" id="YPQGQNA"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF10">
        <property type="entry name" value="RICH PROTEIN MS8, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="21710" checksum="FECA79FD8D6225C3" modified="2013-06-26" version="1">MSGPYDNSYGQQNYGGQNYGGQNYNGQQQYGNYDSNYPPQGQGYQHQGYGGGYQQQGNFQQPYGAPPAPDYTGGQQQVAGGYPPQQGGFQHGGQPQYQQQGYGGYDQQQPQHQYGQQHQPPNGSDPSNPYGYTRDPADPNNPQEGERGFMGAVAGGIGGGLLGHKAGHGIIGALAGAFLGSKGEDKFKEHHNKPQGGSSYGGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVT5</accession>
    <name>N1PVT5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_69130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVT5"/>
    <dbReference type="STRING" id="675120.N1PVT5"/>
    <dbReference type="eggNOG" id="KOG3769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034765_3_0_1"/>
    <dbReference type="OMA" id="YLYSPGN"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="105"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME47048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="460" mass="51262" checksum="BE0DC63844D33E94" modified="2013-06-26" version="1">MKSLRLDRWATQLQPPRNPRLYLFAQRCPFSTAHETRPRRDIRRQHLPSQRHSQPKRWDFELRRHASSAAAVEHDQNDVLSYGREEQPAPLNFPRHREAVKSAKLSALHARLRLPSKVPLQTLARCLIDPSVDLRPGYNNAPLSLLGQELLGYYTSEHIICRYPRLPMPVLFAAQYAYVGPPTLAQVRGEWGVEVVAAPGPEVDPGLLQLKRMPAGNALDESGTMRLKDLPGQKRIRAGLRNDEPFYRRGMSSRIVYDDQFGDLHDNLPSGDERAPYSGAPSAASGEGSEAQTQQRYSTSQETQPATVQHASAGFVRALAGALYLHAGTEAAKAFHKAHIMARHLKLHELFKFTHPTRDLSRLCAREGFEPPVARLISETGRLSRTPVFVIGVFSGNDKLGEGVGASLNEGRVRAAAAALRAWYLYSPPDTEIVLPSDVEGAHSTKRWKPQMVDIGEILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW79</accession>
    <name>N1PW79_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_69540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="3"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW79"/>
    <dbReference type="STRING" id="675120.N1PW79"/>
    <dbReference type="eggNOG" id="ENOG502QUM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016972_1_0_1"/>
    <dbReference type="OMA" id="IVNIDVC"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF42">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02280)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="8">
        <location>
            <begin position="77"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME47622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="384" mass="41628" checksum="3D40873908688D6F" modified="2013-06-26" version="1">MHPNVSASHGEMSSRGGLPPPYESIDSLDKMDGKTGSKWNPRHWSKVAILCAIGAAVLLIVGVIIGAVLGSRANAYPNYSALSYTLADTYSGTDFFDNFDYFTGYDPTSGFVHYVPNATADSSQYNLTYASSDTAILRVDTSETNADTGRYSVRITSKKQYNSGLFVFDIVNTPYGCATWPALWLSDPNNWPAHGEIDVVEAVNQADTGNQATLHTTSGCKMNVKRKQTGGTLYKNCANTTHDNAGCGVQGAQDTYGETFNANGGGIYAMEWRTAGIRVWFFPRSDIPSDIPTDVTNTSAPDPSTWGTPLADFPSTNCDISTHFKNQSIIANIDLCGTWAGSTAVYTDQDQCPGTCTDFVATNNTAFETAYWQWNSWRVYTASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWS2</accession>
    <name>N1PWS2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWS2"/>
    <dbReference type="STRING" id="675120.N1PWS2"/>
    <dbReference type="eggNOG" id="ENOG502S4HG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033083_0_0_1"/>
    <dbReference type="OMA" id="YYVQLAT"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="399" mass="40256" checksum="75700CA7CA6FF960" modified="2013-06-26" version="1">MAEPSAPDADGPDRSPPTLPPGWIAQWDAKSRKYYFVQISTGESTWDVPTMSAHGVPTPGGTPAGQNPYSAPGDGTRGVEGQDSDRSLGGSLLNSVLGSKQSSNQGGLGGLASSFLGGSSNGGSSQQHGSSGGLGGIAQSFLGGSSSHGSGGQQQHGQSGHSSSGGGLGQLGSMASSFLGGHNKPHSGGQNPYGYSQNASSGGPYQGQAPSTSYQAPDSHSQSHTPFAGYGAQSGGYGAPHGSQQRPQHHQQGPGGPGVPAGGYGPQSGAYHPQGQLGFGGHDQSHYGQQSHYGQQEAEQPGYGRHSSTPNDQYGQQHAGGYGQHPPPPPGGPLQGHYGAPGGYGGQQSYGGQSFPPPPQDPSGQYQSYNPQQGGYSSQQGGYGQQTGGYGQSQDSQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX54</accession>
    <name>N1PX54_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_125439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PX54"/>
    <dbReference type="STRING" id="675120.N1PX54"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_2_1"/>
    <dbReference type="OMA" id="IDWKGPA"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF2">
        <property type="entry name" value="ZINC-BINDING DEHYDROGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="83"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME46799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="446" mass="47405" checksum="17B597A8598BB961" modified="2013-06-26" version="1" fragment="single">MPSTYSNSPFVSLKADQNCGRANGSSTSKSFASLSGNATPAVNGSSLNGHVNGHSNGVKQAANGEDEFLRLDAPQQDLLLLHGPRQKYSLEKSRSIPELQGDREILVQVLAIGLNPVDWKGADYGFSQPSYPWVNGRDFAGIVVRAPRDSSRVKQGDVVFGPSTDYRDVRKAAYQEYVVTTDYNVTRVPAGVTVKEGAALGVAYVAAVTALGISFGADFTSLQTAPVGPDLLRLTRTLDRSKVPHDIHNEIFNGIPISERPLPGEWLAIWGANSMTGQITLQLAKHAGLKVACIADIAKGGARLSELGADFLVDKYDDKRAVEILKAVTGGKLRFGIDCNGKDTATSLQDALASTGPRGHLLGLAGLPKNIGPNVVHHQIPIKIFHEAPQVGEAISSWLEDLLVARSLKLPEVEIAEGGLAGINDALDRMRTGKIGGKRIVVPVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXL4</accession>
    <name>N1PXL4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_21859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXL4"/>
    <dbReference type="eggNOG" id="ENOG502SJYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688921_0_0_1"/>
    <dbReference type="OMA" id="THRMRAR"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="45086" checksum="7DBF96A3BFD7A042" modified="2013-06-26" version="1">MTDNNQTTPAFTATLDDSMFAGIKREREDSPLFEPPEGAENGGEGDHNAQEQTPGRERSKRRKTEPAVAPLIPTPTADDHDEPETNLTDMATQEDENPFGSFNFNVADLDASGTETIGHLGFREGYPEVAAYHLAFPLVERKVNSICDFLINYIDQLRALGWKEKDIIPMYEELQTLRNPSHTYPSPEPPAFFGSTGKGKSSTMNALLGTLKAAYEHSGTNRGTYVTHVYMTAPLSQPPGHMAKVHYLDDRGVSVQLFRLCGHVINHLNFDLRTKEDEEDDEEDESEEDFSSYEQKYDTALECLHDALCSEEKFATQDKVAKYLKDLVKKCIKVKMTTDQQVKQLMDDLLPRIKLLVDSRKRVDGVEIIEAFDAQTFQRELKRCTRAARSKDLEACRGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYB9</accession>
    <name>N1PYB9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_50806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYB9"/>
    <dbReference type="STRING" id="675120.N1PYB9"/>
    <dbReference type="eggNOG" id="ENOG502SHE7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018249_2_1_1"/>
    <dbReference type="OMA" id="EPVLAYW"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF6">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109433" description="ASST-domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="65449" checksum="7DA6A14D6CEA0730" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYK3</accession>
    <name>N1PYK3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_50745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYK3"/>
    <dbReference type="STRING" id="675120.N1PYK3"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_921411_0_0_1"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF149">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME47319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33294" checksum="340403F5CB16DBFA" modified="2013-06-26" version="1">MVDAKHSVESTDRRAAQQLHVDIISDTEVMKDVRAAYHASFPLLGQEVYLNQQQQFSLPTGLNVFALGFANVSIVPISNICARRSTSVFFWLSAALAGFVTVILIFCYPETKFHRAPLGQLGQQRKGKNGTAVQEMGAENSEANSQSKVFDGQHVRRGRPGKRTYLDLQHMAENPQTVGYSSFAIFCGGIFGVLTAGLLSDWWTRRMTTANSGIREAEFWFSALWPYCCSLLMWHVSGAVGYQSVWPWQAIAVCGFGFSDLAVTSTPAIAIAYAIDCYKPISEEIMVVGTVLKNVLGFCLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZ46</accession>
    <name>N1PZ46_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_69547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZ46"/>
    <dbReference type="STRING" id="675120.N1PZ46"/>
    <dbReference type="eggNOG" id="ENOG502QYDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007183_1_0_1"/>
    <dbReference type="OMA" id="NTWHEAP"/>
    <dbReference type="OrthoDB" id="19394at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027842">
        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="3">
        <location>
            <begin position="639"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="906"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME47630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="917" mass="101095" checksum="ACDB43F3FCD983AB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZ49</accession>
    <name>N1PZ49_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_102923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZ49"/>
    <dbReference type="STRING" id="675120.N1PZ49"/>
    <dbReference type="eggNOG" id="ENOG502S7B9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059989_0_0_1"/>
    <dbReference type="OMA" id="CMANAET"/>
    <dbReference type="OrthoDB" id="21499at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="10"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="287" mass="33588" checksum="D1897006E0AEC483" modified="2013-06-26" version="1" fragment="single">IFKPDESDDDFVVDEEEEGPLGVPDNGLPIEFTKYASMKPKELFKYAVEWMVQKKINPAFSMNDQLYDLTFKKLDDEVRGLAGSKFTSSAWKPDFILALQARPEIAFERLDRSAAEHYLRDKCDACNRSGHPATWEIQFRGQPYHRNTLEDVANDDDEGEHEESGSDSDDAENNRADRPAWDAQDREIVPETHIFYVGKFCKSNAETAHSLQHWRHALYDWVVTFLTGRGYFHGDRLVEREKWNTKKRRKYANKIVDQMERDGEVKRLWRSFRQQVDVARNSKEGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q015</accession>
    <name>N1Q015_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_167204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q015"/>
    <dbReference type="STRING" id="675120.N1Q015"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_25_2_1"/>
    <dbReference type="OMA" id="FGRRWFI"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME47819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="63324" checksum="6278FAB25C2420F3" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0K6</accession>
    <name>N1Q0K6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_40094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0K6"/>
    <dbReference type="STRING" id="675120.N1Q0K6"/>
    <dbReference type="eggNOG" id="ENOG502SEKR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105959_0_0_1"/>
    <dbReference type="OMA" id="NTGDQAK"/>
    <dbReference type="OrthoDB" id="5309565at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="17530" checksum="4F8D9043BA540A47" modified="2013-06-26" version="1">MSDKETSTLQSYVDKASGAAQSAIGSLLGSQPDVKQGEQKKDIGDARKSVSDAGTTIGGVSVSSSGVAANDPDRQAGSWNQTIGSGKEFVGGALGMDGLKREGQQQNAEGKGQESKGQLNDLSSGIADRVQGTVGGAVAGLTGNRTEQAQYEAQHDQGKTLQRGVESEMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0L9</accession>
    <name>N1Q0L9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_68091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0L9"/>
    <dbReference type="HOGENOM" id="CLU_1713196_0_0_1"/>
    <dbReference type="OrthoDB" id="3641390at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME49212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17539" checksum="AE3604B2955C1635" modified="2013-06-26" version="1">MPDHIPILTTEEVTADRLETISCDLVTKICNDKDFQNSAIEFLDEDFTAINEGNIIHPSRDHFLEAQRQIQLTLPNHLAEVINVTSDINEHKCTATVWMTVKSRGFINGVCIETVSQLSWRRKRAGWICYRHDGIDWCGITPRRHPEVHESTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0M3</accession>
    <name>N1Q0M3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_68093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0M3"/>
    <dbReference type="STRING" id="675120.N1Q0M3"/>
    <dbReference type="eggNOG" id="ENOG502S40Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_802080_0_0_1"/>
    <dbReference type="OMA" id="RYNEDRA"/>
    <dbReference type="OrthoDB" id="5419542at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME49217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="347" mass="39797" checksum="3269B4A32B86C69A" modified="2013-06-26" version="1">MGERQSHKHLPALRTGEAPTQLSPSRSRTDPPAAQHQQHEKSHLHRRLHSNSLRHRAFTSSKEHSHRESAKEIVQSAIDLKPPISFDSLLRRDKKSPDSSRRGSHLPTQHQQARQEDISQTSAEEARRAARRRVRPQDVTKARRENARREEHLRGSLKNVEEVAMSSTRQLDDTYYSILEKASILRSTVASLQQLAEECKRMHSTFQEDATELEQETQRNLNGFNNFNGQEKTINDLVGQLKVSKERTGELNERLEAARNRIEAYEHRWNEHQKKRRKNWGIIWASIIGLIAFMFAVIAAKNRSTLGSTIHQMAKFGNEIASPVAAALRPTGSPVEDPYLRKLFDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0X3</accession>
    <name>N1Q0X3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable aspartic-type endopeptidase OPSB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Probable aspartic-type endopeptidase opsB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_70028</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0X3"/>
    <dbReference type="STRING" id="675120.N1Q0X3"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_3_1"/>
    <dbReference type="OMA" id="CNVTLGT"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110348" description="Probable aspartic-type endopeptidase OPSB" evidence="11">
        <location>
            <begin position="20"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="72"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME48285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="474" mass="49293" checksum="636AD51D0313DE03" modified="2013-06-26" version="1">MRSSTSLAVAAAIASGVHAISLVKRTDTAPRVVEHTIQRKHISNPLEHDRKRWLRKRDDTINVALDNEETLYFMNATIGTPAQSFRLHLDTGSSDLWVNVANSDLCQARGSACSVSGTYSANSSSTYKFVNSDFNITYADGSGSAGDYVTDTVTVGSVSIENQQFGIGYESSSEEGILGIGYPLNEVAVAYTGGRPYANVPQSLLNGGHIATNAYSLWLNDLDASTGSILFGGVNSAKYTGALETLPIIKEDGFYAEFVIALTAVGQNGTSGSIASNLATPALLDSGSSLMYLPNNVTQSIYDATGARYDSSQGAAFIDCDQANSEATIDFTFSSPTIKVSMNELVIVAGEDRGKPICILGIAPAGSSTPVLGDTFLRSAYVVYDLSANQISLAQTNFNSTTDDIAEITNSTGVPSATVVQNAVTSVAVQSGGARINGYTSTLHAAAEPTAAVGYNVAMLGAAAAAAGAALLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q104</accession>
    <name>N1Q104_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_68211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q104"/>
    <dbReference type="eggNOG" id="ENOG502SHKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065607_0_0_1"/>
    <dbReference type="OMA" id="DNMCHIR"/>
    <dbReference type="OrthoDB" id="3359285at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025702">
        <property type="entry name" value="OXD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13816">
        <property type="entry name" value="Dehydratase_hem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="300" mass="33698" checksum="E1B92000D02B3238" modified="2013-06-26" version="1" fragment="single">MSSPSTLRNTIVLQPRAIGSAILARQNTTMGSIGEQERTYPLRKPEGHKPPVPRWSLQFAESIKQVYTLYIGVQSHHGNEEARSQAEAVVESILGDADIQEPVIDTFRVTNGFDLVGSKCWVLYWQYADGFEAALRRLDLQRVWSALGDAKKDIGLWIEHFVAPIERLETNYARLDHKPGLAQLPNTVQPAHELTAYWGAARDRIPASARDLFEAPKDVPLPSSVPTGFGERLTGTNYDNMCHIRSGQWWQNCGEEERAAYEGDLEIKLMAGMEYLWENPKETGTIGLRFLQNLDGKGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1U7</accession>
    <name>N1Q1U7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_67495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1U7"/>
    <dbReference type="HOGENOM" id="CLU_1337485_0_0_1"/>
    <dbReference type="OMA" id="AMSRLEY"/>
    <dbReference type="OrthoDB" id="4158258at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="205" mass="22279" checksum="522C0A68B523C7DC" modified="2013-06-26" version="1">MFSKAKQDAAFNDTSSTAPTLFSDAASAAPTLMYDPNDEPRTTLTGQPIPQQQHSSLSSMTYSEGGIGVTSAAGANLLPPGYTDSSMVRVPIKTADYASPSFHDIKPEKRRSFFSKLKTGSSSEVEVKVIAMSRLEYLKYWVKGEDGKFRADVVEPPEGRAAWVRMQLEINEKWREEGILKDGPDKRVSGPGGFMAGAPAAMFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q299</accession>
    <name>N1Q299_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_122410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q299"/>
    <dbReference type="STRING" id="675120.N1Q299"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078327_0_0_1"/>
    <dbReference type="OMA" id="CLFVTET"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="221" mass="23874" checksum="126FFDEA73C1ECE6" modified="2013-06-26" version="1">MAQSPNIDLLLNLAAERPSTVLEQLQAHPGLASKQDAHGYSLVHAAASYGHEELLRALIRTYNVDPNIADEDGETALFSVEEVRLAKKLIELGTDPSMKNSEGQLAAEKLDDEDEQPDVAAYLRELATEGSDAATTGAQTNGVHPPPPVPGGMQVNVGTMRADEAGEAPDPEFRRRIEELAARPDFQDEAGQAELRRLVEDAISGVTQHVQAPPSTRRRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2H5</accession>
    <name>N1Q2H5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_20353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2H5"/>
    <dbReference type="STRING" id="675120.N1Q2H5"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OMA" id="ITQYSPF"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME49956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="312" mass="34720" checksum="BAB7D3C4C9201CCC" modified="2013-06-26" version="1">MTSTTSHKLNTGASIPAVGFGTWQDKDAQSEAVYLALKNGYRHIDTAHIYGTEPAVGEGIKKSGVPRDQIFLVTKLWNNAHKSESVEKQLDASLKALGTDYVDLYLMHWPSPFQDGDELFPKDKDGKVIPGDADYVEAYKAMEACQKKGKTKAIGVSNFSKAELERLIKETSIVPAAHQIECHPWLQQAGFDAWHKEKGIHITQYSPFGNQNAIYTKGESLGKLIEDPSLNEIGKKYNKSGAQVALAWGIAHGRSVIPKSKTESRIKQNLEGDFKLEAEDMKKIDALDKKMRFNDPSGNFGWDFYKDLDGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2J3</accession>
    <name>N1Q2J3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2J3"/>
    <dbReference type="STRING" id="675120.N1Q2J3"/>
    <dbReference type="eggNOG" id="ENOG502RXXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077738_1_1_1"/>
    <dbReference type="OMA" id="FQGPIAC"/>
    <dbReference type="OrthoDB" id="15735at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000048">
        <property type="entry name" value="Free methionine-R-sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="64"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="175" mass="18756" checksum="C7038AB26DF58347" modified="2013-06-26" version="1">MVHADSSSFAAGVNKTAAYDQIIEQAEALFDGQRNWVCNTANAASLLWHAYHALPSPSNKVNWAGFYIADPSREHHLILGPFQGKVACQTIQFGKGVCGAAASSRATQLVPDVEKFAGHIACDGDSKSEIVVPIVAEDRVVAIIDIDCAVKNGFDEEDRAKLEKLAVVLASACDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q434</accession>
    <name>N1Q434_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_68138</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q434"/>
    <dbReference type="STRING" id="675120.N1Q434"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_67_5_1"/>
    <dbReference type="OMA" id="HDNAYYQ"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071472">
        <property type="term" value="P:cellular response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097248">
        <property type="term" value="P:maintenance of protein location in cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000247">
        <property type="term" value="P:positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045921">
        <property type="term" value="P:positive regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062200">
        <property type="term" value="P:RAM/MOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032995">
        <property type="term" value="P:regulation of fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050708">
        <property type="term" value="P:regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="276"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="583"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="133"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME49264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="657" mass="74707" checksum="F0A2B2B2A4652EE4" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q441</accession>
    <name>N1Q441_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_84707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q441"/>
    <dbReference type="STRING" id="675120.N1Q441"/>
    <dbReference type="eggNOG" id="ENOG502SP6A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079693_0_1_1"/>
    <dbReference type="OMA" id="ETVSWNW"/>
    <dbReference type="OrthoDB" id="3360421at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypervirulence associated protein TUDOR" evidence="2">
        <location>
            <begin position="296"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="357" mass="39645" checksum="89D5D994E0C823B4" modified="2013-06-26" version="1">MPPKDKYTDPELRDQVKEEIQESDKGGQPGQWSARKAQMMAKEYKNRGGGYTTDKDQKDESQKDLDNWTEEEWQTKEGSGSAKQEDGTEKRYLPKKAWENMSEHEKEETDQKKQAESKEGKQYVSNTDKAKKSRKEATEDDDNKNDSKSSTRQTNGHDQAQDKTPKKQQSKQGDGEKDDDNDGNQADKNGTDPEGEEDYVDDGEADVDVDGDEEVEDEPGADDDESDEDQENEPKAGDKRKGGKQSQSNGSSKKQKDNSGNSKNKSNTGDGTVGSKHMKDEAPAQQGSADRLPKEGQDAHWKALPGFVDGKVVEVLTKGKKVDGKDVKASDKEPKIVLKSNSSGKICVHKPEACYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q494</accession>
    <name>N1Q494_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_68816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q494"/>
    <dbReference type="HOGENOM" id="CLU_2427001_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME50083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="91" mass="10040" checksum="749DE3C77306C0C4" modified="2013-06-26" version="1">MSVCCFWSVTTSGQLRNSAEAHRTWTEGADQKPTGTRTRSLALVAVACQSDPWGLRGFDGSRVMLHHSRNSCSVYNVIKTSRLPKNTPSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5B8</accession>
    <name>N1Q5B8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5B8"/>
    <dbReference type="STRING" id="675120.N1Q5B8"/>
    <dbReference type="eggNOG" id="ENOG502RY95">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008869_0_0_1"/>
    <dbReference type="OMA" id="HVVHSKI"/>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="75488" checksum="24AA03894DE9E13B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>M2WIQ3</accession>
    <name>M2WIQ3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_75533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WIQ3"/>
    <dbReference type="STRING" id="675120.M2WIQ3"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OMA" id="KMTRADW"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME38833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="257" mass="27489" checksum="B9A42225BF0A4BEB" modified="2013-05-01" version="1">MASNRPRTLEGRVAVVTGASRGIGEAIAFDLASRGAKVAITYSSNRSREGANKLISRIESEAHSNAIGIQCNLQDVSAPKQIVDETLKAFGEHIDILVNNAAIISDKMLPDVTTEHFDEVMHLNVRAPLLMLQAVLPHLRRPGRIINISSVGAQQGYPGTGTYAASKGALEAYTRNWAAELGKDGTTVNAVNPGPVQSEMLDQVDPEIVKPQKEATLVEKRVGTPEEIADIVAFLAEGRSSWVSGQCISASGGYHCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>M2WK70</accession>
    <name>M2WK70_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_75148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WK70"/>
    <dbReference type="STRING" id="675120.M2WK70"/>
    <dbReference type="eggNOG" id="ENOG502S4UX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050730_0_0_1"/>
    <dbReference type="OMA" id="CDMFITP"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="156"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME39338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="37153" checksum="3FF540F3A97E62C7" modified="2013-05-01" version="1">MGAFETATAVYQTSSHTYNANFRQEWCIGSVPHGGYVTATLLRVVKKHFNTTLSKQSQPHTIALHLDFLRRTQTGPVTFNVKDVKLGRQTSIVHLTLSQDDREEVVGYVTQSNLQKETGLSFFTNFQAHPERVPLSTNLIDLEAGRDPLWTEKRAWPNENFRQATKQIRAWFPRNGQPAQNIYDEWVCLRDPAEKWTNESLGFIVDMFPQICESFYLNGFDQYNPKLDEYFDKEELQRLTKGKAPFWYPTLLLNLEVKKNLGEGVKFLFSRLQTKSIRNGRYDLEVIIWDETGDLVALSHHVCFAVSAERNLAKRTTKGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>M2WLF5</accession>
    <name>M2WLF5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_104821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WLF5"/>
    <dbReference type="HOGENOM" id="CLU_210656_0_0_1"/>
    <dbReference type="OMA" id="WKEMVIL"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="57" mass="6615" checksum="0D22A953FF9FD3F1" modified="2013-05-01" version="1" fragment="single">KVLEDVKTWLKIIRLYQYRSVFTGLSWQRMAMFDDGELESRGVDASAARECLLGVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2WMX1</accession>
    <name>M2WMX1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_80785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WMX1"/>
    <dbReference type="STRING" id="675120.M2WMX1"/>
    <dbReference type="HOGENOM" id="CLU_1129036_0_0_1"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="246" mass="27094" checksum="767C195AC370D2DF" modified="2013-05-01" version="1">MASVDKKALSPGTAQPAQGETIKGKAGRRSAVGAYIRRFDKRPLAYVEVVELPRVTAGHAIDRALAAFGADVINIQSNSLRDFGYLSVTLIAGKRVSQPDLRNERYRAVKVMCRPDLPHQVVRTQRILRRETLVTTDVRLCMESQSYCGQSIGFGRRGGCFPVAFNTDMPMGAVGGADHSHAAVVAFDTAQLKPEFSRYPPDVAKQVQDNHRCASMEPYHMLTDLLDRKVAGWRRTTDVPLAAVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2XHW6</accession>
    <name>M2XHW6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_29237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XHW6"/>
    <dbReference type="HOGENOM" id="CLU_2158289_0_0_1"/>
    <dbReference type="OrthoDB" id="5946236at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="111" mass="11916" checksum="4B82710C59A4F475" modified="2013-05-01" version="1">MSLMYEYIMLNIDRGKFESRSARVSQEARIFLTGGARFGKQKLWACGSIAAGAGQNEINALTRSNLELRGGCGRLAAAFMCKAPDRTSISSISAMCLLSAILKAEAGIVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKW1</accession>
    <name>M2XKW1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_72499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKW1"/>
    <dbReference type="STRING" id="675120.M2XKW1"/>
    <dbReference type="eggNOG" id="KOG1724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059252_7_0_1"/>
    <dbReference type="OMA" id="DKYTASM"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043224">
        <property type="term" value="C:nuclear SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017117">
        <property type="term" value="C:single-stranded DNA-dependent ATP-dependent DNA helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101026">
        <property type="term" value="P:mitotic nuclear membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045841">
        <property type="term" value="P:negative regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000018">
        <property type="term" value="P:regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="5">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="168" mass="19375" checksum="E554F57E5F59BF88" modified="2013-05-01" version="1">MSAENTDTQTVKLVSSDNVEIMTERKIAERSMLIKNMIEDLGAPGEEPIPIMNVSEAVLRKVLEWCTHHKNDPAPSQDDDADSRKKTTDIEDWDQKFMQVDQEMLFEIILAANYMDIKALLDVGCKTVANMIKGKSPEEIRKTFNIQNDFTPEEEDQIRRENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2XZE3</accession>
    <name>M2XZE3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_29661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XZE3"/>
    <dbReference type="HOGENOM" id="CLU_1517818_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="177" mass="20422" checksum="C3873E698B91A737" modified="2013-05-01" version="1">MPKIASAYQSIKDRFYRAPQTYKSLEDLYRRTDPVVNMDFDELVTTKTLELMGKTIYQAEQKVKRLKAALKLLVKDNGRNVTKKPRNEVFSRWNKACCTVSRGVPIAGTCRGETFMSWARRRAAKTSAKEKAKTNTAKEPSHDDVEDHEKIQQNGDGEIEGTNKKPRSKLMRERRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y4A0</accession>
    <name>M2Y4A0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_80623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y4A0"/>
    <dbReference type="eggNOG" id="ENOG502R56C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_860590_0_0_1"/>
    <dbReference type="OMA" id="YYANTYH"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="162"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="323" mass="35079" checksum="B3942EEE0A26F1E6" modified="2013-05-01" version="1">MLGSKTNKFFNYLANKIAPPGSDQGQLYPGAGYPYTVPQYAAPTFDPAQYLSSQGVQYTGATANGQSRQHNGHHIQGDDHRTHASDQAQLYNGNVYYANTYHYYQNEGVTATREQQTSSAPPMTVAGPPSSGARSRPDLPPRQESAPPLPPQPFTQDWSKVFHSSSCDSCGKSPLQGVRWKCVSCPDHDVCADCKAQGNDEGHAFRQLPNQAEQPLRLALLGSHAAQGSQFGVLSALNNNTMYEMCEIPRLDPLVIAARNGHFQVCQTLMEKLGGIWPPQCISAAINGARTAPGYMGNLLAIYLESQATANEQKKSVMKTYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJM2</accession>
    <name>M2YJM2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DUF1640 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_75012</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJM2"/>
    <dbReference type="STRING" id="675120.M2YJM2"/>
    <dbReference type="eggNOG" id="KOG3156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063283_0_1_1"/>
    <dbReference type="OMA" id="MAYMRFR"/>
    <dbReference type="OrthoDB" id="3063476at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME39105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30803" checksum="2854B8877F8EC0CC" modified="2013-05-01" version="1">MAAPLIASAEAASRTMIPRLTWTASSVRPAFSFAQYSSTTAWSTKHNAALRTTSATSTFARNMWAERRSKPPPGITLAISSRRAFSSTPQWRKDHHFDTLKFVQRLQKEGFTEDQAVAMMKVLASVVEESIQNLTRTMVLREDQEKATYTQKVDFAKLRSELLSADTTESGLTRASHERLTNELAKLNNRLRDEVQRTQASVRLDLNLEKGRIREEANTQDLRIKETETRIEQESAALKERLEQVKFSTLQWLMGVCTGAAAIILGIWRLIM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-09-18" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKT1</accession>
    <name>MET1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hps1-dma1 cluster O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">DOTSEDRAFT_139328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2019" name="Fungal Biol." volume="123" first="397" last="407">
            <title>Evolutionary relics dominate the small number of secondary metabolism genes in the hemibiotrophic fungus Dothistroma septosporum.</title>
            <authorList>
                <person name="Ozturk I.K."/>
                <person name="Dupont P.Y."/>
                <person name="Chettri P."/>
                <person name="McDougal R."/>
                <person name="Boehl O.J."/>
                <person name="Cox R.J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="31053329"/>
            <dbReference type="DOI" id="10.1016/j.funbio.2019.02.006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">O-methyltransferase; part of the hps1-dma1 gene cluster that probably mediates the biosynthesis a derivative of cyclopiazonic acid (CPA) (Probable). The hybrid polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) nps1 might incorporates acetyl-CoA, malonyl-CoA, and tryptophan (Trp) and utilizes a C-terminal redox-incompetent reductase domain to make and release the tryptophan tetramic acid, cyclo-acetoacetyl-L-tryptophan (c-AATrp), as the first intermediate in the pathway (By similarity). In addition, the cluster also includes the tryptophan dimethylallyltransferase dma1, the FAD-dependent oxidoreductase toxD, the cytochrome P450 monooxygenase cyp3.1 and the methyltransferase DOTSEDRAFT_139328; the latter 2 being not present in all CPA-producing fungi but involved in additional modifications that occur in biosynthesis the of a range of CPA and CPA-like products (Probable). Further studies are required to clarify whether the CPA-like hps1-dma1 cluster is functional or a non-functional relic reflecting evolution of D.septosporum.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKT1"/>
    <dbReference type="SMR" id="M2YKT1"/>
    <dbReference type="STRING" id="675120.M2YKT1"/>
    <dbReference type="EnsemblFungi" id="EME39475">
        <property type="protein sequence ID" value="EME39475"/>
        <property type="gene ID" value="DOTSEDRAFT_139328"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_4_1"/>
    <dbReference type="OMA" id="HTAMPDA"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF5">
        <property type="entry name" value="O-METHYLTRANSFERASE ASQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000447731" description="Hps1-dma1 cluster O-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="B6F209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="31053329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="31053329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME39475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="433" mass="48521" checksum="31FDF08F2A035875" modified="2013-05-01" version="1">MGGSDHTKTSSQSTLRSLSDEISSLTDVVAGFLESNGHPERSLNSTDSVRLSDAPEDVEAARRRLVTALHEMTLLTMSPFEAVRDILLEVSSLPALHAISHFEIIDHVPLDGEISYAELARKINVPQRRLTRMLRAAMSRSIFQEPRPGYIAHNSLSAAMVHSKWLRYHAASTMENFLPAAPKFVEQIERFGDRETRCTSPAGIAFNTETDCIQYLLSQPKHQQVLVNLMKHTGEISGMGPQHLTEHYDWPKASDQIIVDVGGASGSVSRAIACGVPSVRFVVQDRADAVRQGESETPSELKDRFTFQEYDFFQTQPVKNADVYFLRWILHDWPDEDAVTILRQVALAMGPTSKMLIAERLVLLPGEGDPWDQKIATSMDMFMMAFNGSERTLEHFQSLIENTGEAIEISRVIRRPNGVQYSLIEVARKDSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKX1</accession>
    <name>M2YKX1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_180100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKX1"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OMA" id="IPFLMIW"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000722">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF51">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="51"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME39515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="485" mass="53489" checksum="573408C5EDD57095" modified="2013-05-01" version="1">MSTKEPPVSQASSDLETKDVGIAEIASPVDSISDIDKTTARAAYRKADKRILLWYSFVYLIMRIHVSNITNTAIINIQEGDGIKQQLGNLNSEQWAWVLSIFYYPYMFAEPASTVLLKHFSPSVWMSRIMVTWVGIISMCQGATQNYAGILVTRFLLGLAEAGYYPGVLYHLSFWYPTKRTSLRIAFFYACGQFSGTISGLLAFAVSYMNGVGNLAGWRWVFILEGIPAILCGVYTFFMLPNYPETSKFLTEEERRTILDNLPKTQPSSTAKTWNTAQVTAIFTDPTTAAFTLIWIFHAIGGWGVQNVLPTVIYELGLTNPAISQLLTIPTYAFGCACLVVIGWTIQRRKLRPWVAAMALEVLTMICYIILIVVKSSVAKYVLVTLATSCSICIYPILWPERIRVAHGTTAAGLTIGLTNAAAQFSGILGPQVYQPKFGPSYKVSYSVSIGLLVGAIVSIAATWCLVARKDRAQTSTDLRAAEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>M2YL78</accession>
    <name>M2YL78_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_38851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YL78"/>
    <dbReference type="HOGENOM" id="CLU_1652102_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005358308" evidence="1">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="160" mass="17835" checksum="F3EC307BD05450A4" modified="2013-05-01" version="1">MLRSQPVFATLLIATDILLLLEQRVTYYVQLGSSCAANSWAQRTQSLASPILGDTGSFIVHPSEDLPSYLEIELYATAMDDVIGVGLSPSSDLQIRQSRAYEKRCHTTDNLWVLPHSGLDGGNPYRHRGSDSLLPTDWRAHVAVTSWAESHKTQLCLYCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLZ9</accession>
    <name>M2YLZ9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_72439</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLZ9"/>
    <dbReference type="STRING" id="675120.M2YLZ9"/>
    <dbReference type="eggNOG" id="KOG1255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_1_0_1"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="51"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME43041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="349" mass="36290" checksum="1F325C2664328BBA" modified="2013-05-01" version="1">MQSIRQPLTRALRNAPAGLTKSVAPATYATISPSEAPGQPSGYAKTGLNLRVTKDTRVIFQGFTGKQGTFHASQAIEYGTNVVGGTNPKKAGSEHLGKPVFANVSDAVKEVKADASVIFVPPPLAAAGIEEALNAEIPLAVCITEGIPQHDMVRITDMLKTQDKTRLVGPNCPGIIAPGQCKMGIMPGFIHKRGRIGIVSRSGTLTYEAVNQTTQAGLGQSLVIGIGGDPFSGTNFIDCLRVFLADEDTDGIIMIGEIGGTAEEDAADFLKEYNVGGKDGKGKPVVSFIAGISAPPGRRMGHAGAIVSGGKGDANSKITALEAAGVTVEKSPASLGKTLREQFIQRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>M2YMM2</accession>
    <name>M2YMM2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_131702</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YMM2"/>
    <dbReference type="STRING" id="675120.M2YMM2"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OMA" id="NAGIKGH"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME43185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30835" checksum="96AA3DE968DA40C6" modified="2013-05-01" version="1">MTTSKRSVLITGCSDGGMGAALASEFHRVGLHVYATVRNISKMEPLERAGIETLELDIASEDSINACVKTIRQLDILVNNAGAQYTMPISDLDLAKAKKLFDSNLWGHIAMTQACLPLLTKSPKAIVVNHTSVGAGQAIPFQAAYNASKAALAMFTDTLRMELQPFDIAVVELRTGGVKTNVIKNVQAQPPKLPEGSLYSPARKALEEKLTMKWAEDIGVPVDQWAKNVVVDLLQENPPRQIWRGEKAWLSWFVSCLPATIFDNMIKGTAGLAKVEQILRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2YND2</accession>
    <name>M2YND2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YND2"/>
    <dbReference type="eggNOG" id="ENOG502R9BT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1205221_0_0_1"/>
    <dbReference type="OMA" id="THVTWRA"/>
    <dbReference type="OrthoDB" id="3649457at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="221" mass="24281" checksum="529C958117B1EC9F" modified="2013-05-01" version="1">MATSTQIAPTMSDMSKLGLSLDLTSDADLTPASETTTLKSETSTLNEQNMSVASSRSSICSFSTDNSNILSPLSSTKTAKKVRFEESVSWSYFDDPASETRPEPDRRASFLGRSWQRFKQRNTSGDLDITPPAIQLQQLKRQNSSMDILSSSQKGAKSSLLASSAARRSSMAYSERHPLREGTGRRFNGAKTHVTWRAREVTAKGDWGDLLSNPRQSALYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2YNN7</accession>
    <name>M2YNN7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_54398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <title>The Genomes of the Fungal Plant Pathogens Cladosporium fulvum and Dothistroma septosporum Reveal Adaptation to Different Hosts and Lifestyles but also Signatures of Common Ancestry.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Okmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H.A."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">NZE10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YNN7"/>
    <dbReference type="STRING" id="675120.M2YNN7"/>
    <dbReference type="eggNOG" id="KOG1689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068704_0_0_1"/>
    <dbReference type="OMA" id="NDEWEIG"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="31166" checksum="4940200EBDB6D8E8" modified="2013-05-01" version="1">MSTVTPAHQLSSVPAKDILPFQSRQQPAVRLYPLSNYTFGTKETQPEEDASVKDRLKRLEEYYEKHGMRRSCEAILVCHEHNHPHVLMLQIANAFFKLPGDYIPHDVDEVEGFKDRLNERLAPTGSLAEKDDRDWNVFDTIAQWYRPNFETFMYPFLPPHVTRPKECKKLYFIQLPKEKVLSVPKNMKLLAVPLFELYDNSQRYGPQLSAIPHYLSRYRWEFVDEDGKVVSWSPGGEVDERVKTKILAGGENGHAESGAVSDVKMESQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>M2YNS9</accession>
    <name>M2YNS9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_72897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YNS9"/>
    <dbReference type="HOGENOM" id="CLU_2170997_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="110" mass="12164" checksum="8183DEAE6B8FA2F6" modified="2013-05-01" version="1">MYERLSSHSILVFGSWRRATYEPGSPYSTCSIAPLKPECTDNTSMQPQHGTCDRRTLPRTALLPSQLEDVAQCVALISDLIMGSTTHQNRIVSTSSNKCVAMWFTAIQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC38</accession>
    <name>N1PC38_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_29606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC38"/>
    <dbReference type="STRING" id="675120.N1PC38"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029940_1_0_1"/>
    <dbReference type="OMA" id="ANWYMED"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF2">
        <property type="entry name" value="HYPOTHETICAL POLYSACCHARIDE DEACETYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="48"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="315" mass="35880" checksum="9153D36A6770E57C" modified="2013-06-26" version="1">MSSSKPKNKLLIAWSIDFDAVSGWLGTGQHPNNSTADYSAGYFSAHVGVPRLLKLFEKLQIADKVTWAIPGHSIETFPEQTKAIINCGAEIALHGYAHESASQMTAEQERDVLMKCVNLVEELTGKRPRGYRAPLYQLKERTISLLQEHDFLWDSSLSHHDSAPYFLPQNPAPIEPITFSPDAKAADWMHPSPTFTSLPKSSLVEIPCNWYMEDMTPLQFFPNTPNSAGYVDVRVVERMWMDRFEWLLKEIEEGREDLVVFSMVIHPDTSGMAHVIGMVERFLRWVVGHGNRVEFRTCGSVAEEFRRRREEEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC88</accession>
    <name>N1PC88_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_29456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC88"/>
    <dbReference type="HOGENOM" id="CLU_1686526_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="156" mass="17016" checksum="9701CA7AFBDB5D2E" modified="2013-06-26" version="1">MDCFSALAYLLIKFPFRFQRTAATPQAEAQAPVPPSRLPSSARAGIGITSSAPVAKPQTFITGTPEVSLDWRSSSGMGGQGGRTEHIRKEKHPEEIREDFGIYWLVLDAAASGLTTTLHMTAGFLDHMAIENALYDNECTPQHNVPRIPIWGVHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCI9</accession>
    <name>N1PCI9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_74765</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCI9"/>
    <dbReference type="STRING" id="675120.N1PCI9"/>
    <dbReference type="eggNOG" id="KOG0769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="OMA" id="PLEMINT"/>
    <dbReference type="OrthoDB" id="446044at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015867">
        <property type="term" value="P:ATP transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="122"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="215"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME40002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="38462" checksum="767B69DF7598087A" modified="2013-06-26" version="1">MTMAPALSKEEMPAWGLALAGSAGALVANALVYPLDMVKTRLQTQVKRTAKDTHVDAAGYVHYDGTMHAIMHIIQEEGVSGLFQGMTGNLIGVVSTNFAYFYWYGLVRETYHKRIAKNNAPASTAAELSMGAVAGALAQLFTIPIAVITTRQQTQLKHERKGIFATAKEIVDSSEGAAGLWRGLSASMVLVVNPSITYGAYERLRVIMFPGKTRLALHESFILGALSKQIATLLTQPLIVAKVGLQSRPPPQRQGKPFTSFLEVMKYIVEREGFLGLYKGVGPQLLKGFLVQGILMMTKERVELAFVLLFRAVRKMRQEQLDKLAKIAAEKIDQAKEQAKQVVNETKKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCR2</accession>
    <name>N1PCR2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_74823</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCR2"/>
    <dbReference type="STRING" id="675120.N1PCR2"/>
    <dbReference type="eggNOG" id="KOG4159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017137_2_1_1"/>
    <dbReference type="OMA" id="CIRCLIV"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="4">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="389"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME40097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="55357" checksum="97E6D6146C26B53B" modified="2013-06-26" version="1">MKFGHEYETALANEGFPQEWVANAIEYKHLKKCIKRVHRELESLGLDEHTLHAMSELVAQPKTPKSSSLKDYFSAANPSLYAIQEEFTPQLRILVDSNGTPLDARLAPETKASLQQLAKHEMVVAGRQRHAEERQARRPSQVERHLSVGSDEASPERKHSLVPETPETKWIQVPLSSAQDFFDMLEPKLGGLETLRDSETHALEDKILDLGDAVEDVVAPVKEGYEAHREISYRDLYFWREMFRLYLENPIFYKETEQSRGAITFHEAKHNLQEYDQKLRETGLLAKMRTPQAKIAAQRFLDLNLDILKAMHFQEMNARAMKKILKKFDKQTGLEGKTFVKNLQIKYPEMLTNGKNVAGGFANSIARDMQAEMGSKVLAIVPQLDDWVCPVCYGMAWRPVNLGCCKSVFCIRCVIELQSKGMKKCPMCNAESVMAATGKNIDFETMDFLGVFFPMEVKKRQKDNERAQMLRDYGEEFVKPGCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCV9</accession>
    <name>N1PCV9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">spt1</name>
        <name evidence="12" type="ORF">DOTSEDRAFT_178752</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCV9"/>
    <dbReference type="STRING" id="675120.N1PCV9"/>
    <dbReference type="eggNOG" id="KOG1358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_0_2_1"/>
    <dbReference type="OMA" id="ITIRHAI"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000059">
        <property type="entry name" value="Serine palmitoyl CoA transferase subunit LcbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="128"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME39899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="523" mass="57537" checksum="BFF4D5A6C85EF7DC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD21</accession>
    <name>N1PD21_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_47610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD21"/>
    <dbReference type="eggNOG" id="ENOG502SATA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124525_1_0_1"/>
    <dbReference type="OMA" id="SGMMMKL"/>
    <dbReference type="OrthoDB" id="5426707at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="131" mass="13933" checksum="AF31B68AF9573CAD" modified="2013-06-26" version="1">MARTAKTTTKKPSLLSRLRNKNQAKVTTSQSTNPITGTTTTTQTTKTHPNGYGSRGHGGRGPMASNREHHYTNTTSIAGVHHQKRKVSMGDRVSGAMMKLRGSATGKSGVKGAGTKRMQGTDGRGSRRVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD67</accession>
    <name>N1PD67_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_55726</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD67"/>
    <dbReference type="STRING" id="675120.N1PD67"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_1_1_1"/>
    <dbReference type="OMA" id="HVDVLTN"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000002">
        <property type="entry name" value="External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000005">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 64 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="544"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME40543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="697" mass="78657" checksum="F3564A7915D088B2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDC0</accession>
    <name>N1PDC0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_28019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDC0"/>
    <dbReference type="HOGENOM" id="CLU_1855226_0_0_1"/>
    <dbReference type="OrthoDB" id="3649991at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="138" mass="15499" checksum="6F2E87E0CC76BA90" modified="2013-06-26" version="1">MDFKTVAICPESPSSELHSWQLLYITSHQTAMHRLVPGTNERATSRNIATIKFPKVIWPGCGPTITFQPHEVEIKKRGLRHGSPTDRFMACTGRLSTSYGIDLSALGGARVKWKAPTRQEPESAWQGRELEQNPRMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDG9</accession>
    <name>N1PDG9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_161080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDG9"/>
    <dbReference type="STRING" id="675120.N1PDG9"/>
    <dbReference type="eggNOG" id="ENOG502QW5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012945_0_0_1"/>
    <dbReference type="OMA" id="HWWLPND"/>
    <dbReference type="OrthoDB" id="5278208at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="673"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME38245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="702" mass="79032" checksum="0DB46146F19F20BB" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDH1</accession>
    <name>N1PDH1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exocyst complex component exo84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_74254</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDH1"/>
    <dbReference type="STRING" id="675120.N1PDH1"/>
    <dbReference type="eggNOG" id="KOG2215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012488_2_0_1"/>
    <dbReference type="OMA" id="AAWLPNR"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000264">
        <property type="entry name" value="Potential exocyst complex component Exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="13">
        <location>
            <begin position="490"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME40643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="717" mass="78310" checksum="E178E33B11FE9524" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDV2</accession>
    <name>N1PDV2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_177599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDV2"/>
    <dbReference type="STRING" id="675120.N1PDV2"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023193_1_0_1"/>
    <dbReference type="OMA" id="NKPTGFE"/>
    <dbReference type="OrthoDB" id="435402at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033167">
        <property type="term" value="C:ARC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018606">
        <property type="entry name" value="Arb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09692">
        <property type="entry name" value="Arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="6">
        <location>
            <begin position="61"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="575"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME40547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="611" mass="69375" checksum="6655E0AD0D075A0A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1PED6</accession>
    <name>N1PED6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="13">PE methyltransferase</shortName>
            <shortName evidence="13 14">PEAMT</shortName>
            <shortName evidence="13">PEMT</shortName>
            <ecNumber evidence="13 14">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_74291</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13 14">Endoplasmic reticulum membrane</location>
            <topology evidence="13 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13 14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="13 14"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PED6"/>
    <dbReference type="SMR" id="N1PED6"/>
    <dbReference type="STRING" id="675120.N1PED6"/>
    <dbReference type="eggNOG" id="ENOG502QRGH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005987_0_0_1"/>
    <dbReference type="OMA" id="RIWYSVG"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 13 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 13 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME40692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="983" mass="111863" checksum="06CF9F7139DF5E8A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEE6</accession>
    <name>N1PEE6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_55839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEE6"/>
    <dbReference type="eggNOG" id="ENOG502R11M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1594505_0_0_1"/>
    <dbReference type="OMA" id="TTMRCAP"/>
    <dbReference type="OrthoDB" id="10308424at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18874" checksum="B8D0D8827DB941E6" modified="2013-06-26" version="1">MSDSRPWLQDLTDIRHTGLSNDSPHETELLSRQVHKALNEGQFDHGVWSRVSEHFQHVTPDFSGFTDVGRGVMYLQDILNARKRMTEANPAYRSVVTDSHTYVEKSLRNADVMLVLRHVGLAGGREEDGVQILRWKKVMGVWMCTKSTTMRCAPVLADEITTHLAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEI5</accession>
    <name>N1PEI5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEI5"/>
    <dbReference type="STRING" id="675120.N1PEI5"/>
    <dbReference type="eggNOG" id="KOG2142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010913_2_1_1"/>
    <dbReference type="OMA" id="QEQGWHV"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043545">
        <property type="term" value="P:molybdopterin cofactor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="44"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="597" mass="66677" checksum="2A17250731A01C4B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PER8</accession>
    <name>N1PER8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_74609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PER8"/>
    <dbReference type="STRING" id="675120.N1PER8"/>
    <dbReference type="eggNOG" id="ENOG502S1DJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_0_1"/>
    <dbReference type="OMA" id="AAIWIHK"/>
    <dbReference type="OrthoDB" id="10260355at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109327" description="FAD/NAD(P)-binding domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="31"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME39761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="403" mass="43747" checksum="5434F129B7841CE5" modified="2013-06-26" version="1">MWSSTILGLCLLAASITEAAPSLAPAVKADYDAIIVGGGPSGLAAASGLGRVRRNVLLVDSGEYRNNATRHAHDIIGYDGVTPAWLRFSARQQIGHYDTIALVNGTVTDIQPEQSANGTTLFTVSITYPENKPVTFTTRKIVLGTGMKDILPETPGIEENWGKGIFWCPWCDGTEHADQALGILAELSSAVTTIREILTLNTDIVLFVNGTDTPEYRAEADLALPGWERYLQLHDVKLENRSISSVTRLRDGATPFADPSLPTNPEHDLFQVDFTEGGESILRNAFLADFPSEQKSTLGQDVGVQLLGTKLSANSSKGLATNIDGIYAIGDANSDNITNVPHAFFTGKRTAVYLHVQLERENSGAQIGVVSTSSRKREEESLRSIWERVNHEDDITYAGEFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1PES4</accession>
    <name>N1PES4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PES4"/>
    <dbReference type="eggNOG" id="ENOG502SC0A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135765_1_0_1"/>
    <dbReference type="OMA" id="NPPDSNR"/>
    <dbReference type="OrthoDB" id="3358750at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475:SF1">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="120" mass="13409" checksum="BA77D5D89EC770A7" modified="2013-06-26" version="1">MSGTSNVGQSQVYEAGDQRNAPKSEQENADRFHEGKENSHLPNDSKDERTIANKLEREAKREHEKDEPKTEEDRARKVDATLPAKNHGNEPSKGAKIDQELREEEEAILAKKGSFGPKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEW1</accession>
    <name>N1PEW1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_82412</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PEW1"/>
    <dbReference type="eggNOG" id="KOG0343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_241972_0_0_1"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="79"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="268"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="12">
        <location>
            <begin position="1520"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="492"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="673"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="781"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="922"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="701"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="740"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="941"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME40907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1666" mass="183759" checksum="0A22CC367414E9C9" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEZ2</accession>
    <name>N1PEZ2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_74851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3R)-atrochrysone 2-carbonyl-[ACP] + H2O = (3R)-atrochrysone 2-carboxylate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64236"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:20479"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:234107"/>
            <dbReference type="ChEBI" id="CHEBI:234110"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:64237"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEZ2"/>
    <dbReference type="STRING" id="675120.N1PEZ2"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048478_1_3_1"/>
    <dbReference type="OMA" id="GDHVMAW"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000328">
        <property type="entry name" value="Lactamase beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="68"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME40155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="318" mass="35612" checksum="566E01E6613D9BD8" modified="2013-06-26" version="1">MFNCMVYVRRLVPGTIQNTCCLQRTKRATTRPYTIKMEQLPTLPDIERVSPRVIRILGANPSKFTLQGTNTYLIGQGPKRFLLDTGEGKPQWLDSVKKALKDENASISDVILTHWHPDHVGGVPDARSLCPEAKVWKNNLYAMKDYINYNDGHIFRTEGATIKAFHSPGHTVDHMAFILQEEDAMFTGDNVLGHGTAVFEDLATYIDSLERMQHQFDGRAYPGHGQVIGDGKAKIREYISHRRQREVEVLEVLKASAPGGEEGWTSMEIVKLVYKAYPEHLWTPAEGGVKQVLGKLEGEGKVKQADGERWSLGAKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF25</accession>
    <name>N1PF25_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allergen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF25"/>
    <dbReference type="STRING" id="675120.N1PF25"/>
    <dbReference type="eggNOG" id="ENOG502S2AG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047590_0_0_1"/>
    <dbReference type="OMA" id="EGCPTFD"/>
    <dbReference type="OrthoDB" id="2118965at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="30835" checksum="9CD0034D2B618CF2" modified="2013-06-26" version="1">MDKAKAAVQDFMSKAGHHDTTVHEKVAPAVQNETVTRTHHDNVTTAVDKEVHQDHYHTSVQPIKDTETLPEQHHHNMVAVEHRNFEHGNKGDVDRKLNETAGQFRDTSQRVEGQHTTSNAPAIGGEHIHHHVHETIQPVVNKQTIEPHVTHTTVPIHEVHHNSAQHHATSALPAVSMADFKKQGGVLSGREERYDGFEGEPRSLGGNATGTHSTGLTGERGLTGDHSHGSHGAYAGGAAPAGGIGEGVGSGAGLTNSNTNTTTGSKPSLMDKLNPKKDADGDGKAGFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF55</accession>
    <name>N1PF55_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="12">2.4.1.132</ecNumber>
            <ecNumber evidence="12">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_74302</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 12">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="12"/>
    <dbReference type="EC" id="2.4.1.257" evidence="12"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF55"/>
    <dbReference type="STRING" id="675120.N1PF55"/>
    <dbReference type="eggNOG" id="KOG0853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030619_0_0_1"/>
    <dbReference type="OMA" id="AMYMKCP"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="14">
        <location>
            <begin position="22"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="220"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME40714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="490" mass="53907" checksum="9FF10381CB08DB31" modified="2013-06-26" version="1">MVAESKSASTRNIVFVHPDLGIGGAERLVVDAAVGLQSLGHKVTILTSYRDKSHCFEEARDGTLDVRVRGDAVFPTSIAGRLHILCTILRQLALVASVALSSSELKQIAPDIFVVDQLSVCVPFFRLLYPKAKILFYGHYPDRLLVKGETGLPGRLKRLYRIPFDALEGWSTGCSDSIVVNSRFTRNVFKATFPGMKARDLKVIYPCVDTNQASAVQASIQSSADRKILLSINRFEGKKALDLAIRAYAKLSADERSKARLVLAGGYDPRNQENSVTHMRLQDLAESLSLKHATYSKQDTASTDLTSQDVDVLFLLSIPNEVKTRLLQNAGLLIYTPTNEHFGIVPLEAMLFGVPVLAANSGGPLETIYEGRTGWLRDPEQVEKWTEVMRKPLIPSSADTLRKMGEQGRQRVLNEFSQTKMVQTFDQELHKLVKSDAPRPAIAPSWLLVAAGLTLFAIIGGFAMMQLTFYAPSLEETNSAVAAASSRVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFB3</accession>
    <name>N1PFB3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_82883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PFB3"/>
    <dbReference type="eggNOG" id="KOG0929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001772_0_0_1"/>
    <dbReference type="OMA" id="FYTSIQK"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF373">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="810"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1470"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1697"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1765"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1830"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1472"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1491"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1502"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1698"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1783"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1834"/>
            <end position="1845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1998" mass="218000" checksum="89451713A5EDF871" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFG0</accession>
    <name>N1PFG0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_136186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFG0"/>
    <dbReference type="STRING" id="675120.N1PFG0"/>
    <dbReference type="eggNOG" id="ENOG502QVGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_1_1"/>
    <dbReference type="OMA" id="WHAYQNY"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109347" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="60"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME41107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="517" mass="54733" checksum="87DC96CABF58F677" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PG38</accession>
    <name>N1PG38_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_136948</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PG38"/>
    <dbReference type="STRING" id="675120.N1PG38"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_14_2_1"/>
    <dbReference type="OMA" id="STRVVHY"/>
    <dbReference type="OrthoDB" id="2096480at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME40535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="366" mass="40408" checksum="08AB2E1C352A3054" modified="2013-06-26" version="1" fragment="single">MANLAGIPIVETPVLVVGSSMVGMTLSALLAKHGVRDCITIERHSSTAIHPRAALFHPRTMQIYRELGLYDQMYNESLKHYDEHAGLHAVESLAGKKLGTWMADINQWIENISPTSRLFLTQQMFEPLLRQHAVDNGAILRFSTELVDFQQDEAGVTALIQDLDSGKKELVRTKYMIACDGSKSPIREKLGIQMKGHGLLSHSLTIYFKADLGWLVQGKYNGVIYVNNEDVRGFFRLDKTGREGFLVVNTAGKKGTEESKHPSVGITNEKAGRMLKSAIGADVDFEITLLSPWNALCDVADRFNDRRVILAGDSAHVVTPNGGFGGNTGIHDAHNLAWKLALVLHGKAGEELVTQTYHDERRPVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGT9</accession>
    <name>N1PGT9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_156921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGT9"/>
    <dbReference type="HOGENOM" id="CLU_1777394_0_0_1"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="146" mass="16352" checksum="6FDECB8D2357F283" modified="2013-06-26" version="1">MCTARARGRSCTAGEMASPSENPPLLTTNIAPAHPPTPSFPHTSTHPAFIIFTLSTLLAHPRPPYPKRYRRRQALLIRTIGEVVQWQDRRALRQAKACQLGAREFDALLLQLFFASCDIQMAPFGESHHQCKVIMSVHVCMHGNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGY4</accession>
    <name>N1PGY4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGY4"/>
    <dbReference type="STRING" id="675120.N1PGY4"/>
    <dbReference type="eggNOG" id="ENOG502RHTN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1855239_0_0_1"/>
    <dbReference type="OrthoDB" id="10434656at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004108798" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="14238" checksum="FB7BEE2BD177A673" modified="2013-06-26" version="1">MLSPTSSSTILAAILIMMTSTSATPLEPTYPLRARAVQTVYKYMSATTAPLATVTPIAKVTCPDSIVTNKGDCPSACTAAAIPVMLGIATDSWSCVVPPAETLWTSVEATSTCAPGSAVTTYTLYGGQYQMGCKATTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH83</accession>
    <name>N1PH83_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_135006</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH83"/>
    <dbReference type="STRING" id="675120.N1PH83"/>
    <dbReference type="eggNOG" id="KOG3889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021859_3_2_1"/>
    <dbReference type="OMA" id="KYKWGFC"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="10">
        <location>
            <begin position="7"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME41692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="254" mass="28195" checksum="A3D12042CE95DE4D" modified="2013-06-26" version="1">MSSLLTQIRTHGFCFIDAMPATPEATESLLKSIGPIRETHYGGFYDFTSDLSLKDTAYTSEALEPHTDNTYFTEPAGLQALHMLSHTEGTGGESSLVDGFNAATQLYVEDRDAYIVLAEMGVYAHASGNEGISIQPSHAFPTLNHDPEGGYLTQVRWNNADRAGIAADLKDVERWYDAAAKFDAILNDPKNVYWFRLQPGCMVIFDNWRVLHGRASFTGKRRMCGGYIPRDDFISKYRSVALEKEDVAFSTVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHV5</accession>
    <name>N1PHV5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_178527</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHV5"/>
    <dbReference type="STRING" id="675120.N1PHV5"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018353_0_0_1"/>
    <dbReference type="OMA" id="ERPYETH"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF532">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME41125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="817" mass="90466" checksum="BC4B78E73B52574D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHW6</accession>
    <name>N1PHW6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_55051</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHW6"/>
    <dbReference type="STRING" id="675120.N1PHW6"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_416200_0_0_1"/>
    <dbReference type="OMA" id="AHERWCK"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="413"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="348"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME41140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="659" mass="73673" checksum="664B3F747E00850C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK13</accession>
    <name>N1PK13_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger Mcm10/DnaG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_73892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MCM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK13"/>
    <dbReference type="STRING" id="675120.N1PK13"/>
    <dbReference type="eggNOG" id="KOG3056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_704036_0_0_1"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="3">
        <location>
            <begin position="67"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME41636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="392" mass="42776" checksum="AE22832E65C3DDA5" modified="2013-06-26" version="1">MVLKLCDLKWEIDCFLFGTAFNQFWKLTSGTLLAIMNPAILPPKGNRHDGKFSLKLGSSEDAVMEIGIARDLGYCSATKKDGQKCTEWVDKRKTEACEFHLNLQIERARKGNMAVNTMFRGTGNPQDRIKSKVARDAELRKKKVGGQHHRGYGQLYHVHGGGKSAASILDSEDMDALHNMTQEEVSRKRLANAQKERDLARKLGEIGSGVGAEYLRTKHTQTDSITTVTSTTSHQGTAAEEARRELFAKPSASELGLLGKKTTDVHMSPPKDRKKHFGLGAVSMASNSSGSKSSAPMGWGGAKKAGLIQPKESRLAGPERGQTMLTMETTRPDLVRPRSQNSSLRSAGSSSPIKKKARYLLEEKGIRTPGRDSLPGAGVGVEDDDDDDLDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK35</accession>
    <name>N1PK35_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_155281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK35"/>
    <dbReference type="STRING" id="675120.N1PK35"/>
    <dbReference type="eggNOG" id="ENOG502S1Q3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024063_0_1_1"/>
    <dbReference type="OMA" id="GSWIVQS"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="349" mass="38146" checksum="CC55BDA921FF4E1C" modified="2013-06-26" version="1" fragment="single">MKEVEANATATKEHQNPSEGDANGNALDQVKADENEEGTTSNAEESKDGNNGAAEGTAVQEDKQREKAQPSNIMEKGIIYFFTRGRVGVEEPNSVSDLQRSFFVLRPLPPGGKLGEGAIQDVGNNRLIALPKKVWPKSGADKFMAFVEKAKTDMDDLKETFFQGSSYSTKTTGTRHTPQVTPLGEGVYALVSTGEGRTTTHLAYQLTIPQQIGDVQKDVGIAEKGSFVISMKNPEGGAPSYALPATAEYPKEILEEFGSLAWLPARPHHLDYDNAAFLLIGESFDDGKGKALEPKAQDEQEDDKNVPKEELEQLEKEDEHRIDALKGDDTIFEDLGISSKDYPKVPTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK61</accession>
    <name>N1PK61_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK61"/>
    <dbReference type="HOGENOM" id="CLU_1378093_0_0_1"/>
    <dbReference type="OrthoDB" id="3642232at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="198" mass="21083" checksum="31B0875F41143004" modified="2013-06-26" version="1">MAAELSLIDPRKKSHRRDTSSIGSIRSDKSAASKASTSSQKSVYCDLLGVRTKEKEPANHTSTSRLSQVGSIASGATGSSSSSDASTITNASSKSSTSMTEHDVFGTKLPPTEEELAPSAPDAVELESGKYKIPEIMNKQFFKDLTCLEDEELIGKYGLTPIREEATGRSKKQNDGGIFKRMVRGSKIGSATSVKATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKB8</accession>
    <name>N1PKB8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_174788</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKB8"/>
    <dbReference type="eggNOG" id="ENOG502QS9Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012331_4_0_1"/>
    <dbReference type="OMA" id="WSQIRYA"/>
    <dbReference type="OrthoDB" id="3627416at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME42010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="656" mass="74395" checksum="A66F84263B76B0C8" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKQ7</accession>
    <name>N1PKQ7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_27004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKQ7"/>
    <dbReference type="HOGENOM" id="CLU_1189901_0_0_1"/>
    <dbReference type="OMA" id="CGGYHYV"/>
    <dbReference type="OrthoDB" id="10331464at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="233" mass="26215" checksum="5F1E70852C091B58" modified="2013-06-26" version="1">MSCTLDSGAVRFDGIERSSKHGEAPLPAPQKLASGLYPCEACGGYHYVPRCIYILPWSEWLAYLYEYMPSQLDQLAGIANISPSQLDKESLVERVQWLDRLSETHRPNYVGKSRMKADIMTGSTIDAYWLESVWQSKLKAGSAYHTRKKRLQSHAAGNPYGTSTDGYESEDDSSKIEHLKAVFARHLPRTSTATLFKKNDLQTVEHDEDGGWELVDKPTNLSIRERRVMASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKU7</accession>
    <name>N1PKU7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_54994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKU7"/>
    <dbReference type="STRING" id="675120.N1PKU7"/>
    <dbReference type="eggNOG" id="ENOG502RXHH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_286371_0_0_1"/>
    <dbReference type="OMA" id="NTINQEG"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="663"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="974"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="984"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME42714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1079" mass="119389" checksum="CA2A757D76A83AC1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLA4</accession>
    <name>N1PLA4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_34763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLA4"/>
    <dbReference type="eggNOG" id="ENOG502R9BG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_490912_0_0_1"/>
    <dbReference type="OMA" id="IKREHAC"/>
    <dbReference type="OrthoDB" id="3647228at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="555" mass="61502" checksum="780E83B662510838" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLH9</accession>
    <name>N1PLH9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLH9"/>
    <dbReference type="HOGENOM" id="CLU_2171000_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="110" mass="12651" checksum="094BBCC2F8645E9E" modified="2013-06-26" version="1">MGEDDRQRIYDKWMALRGLHSGTIAWCIEVRRLVCRRHFVGTASLNAGRVPRLVIPPHVEVRTHEAGMHPAPRYLARMQRLSVSILQVILRHQSSTSFQTRPVGVRTWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMG4</accession>
    <name>N1PMG4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_46147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMG4"/>
    <dbReference type="HOGENOM" id="CLU_2084793_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="117" mass="13065" checksum="CBC415B9552348AA" modified="2013-06-26" version="1">MPRSGTKPLDPDPVHEKAHNAPLPQFILNMMKPFHLHYLARCANAVELQAARATKHVIPTAQPCTGRFPNCVSKTQPHIVRSIRTRTSHTRISGTQSAYCKSESMPACVYRVRFGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMI5</accession>
    <name>N1PMI5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_175986</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMI5"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OMA" id="MAYSSMP"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="13"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME42715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="506" mass="55833" checksum="93C968A7FF616723" modified="2013-06-26" version="1">MALLEGNALLYTVSLLTCMSFLLIGYDNGLMGGLVNTEHFDSTFNIDVKTDSGTNMIALIVAIFEVGCFFGAIITSFVGERLGRRRSIFGGVVVMIVGAILQATAYTRAHMIVARIVAGVGLGAINSTAPVMMAEFAPKATRGIYVCAQLSCLNFGIMFVYWIDYGFSTIPGSHSYAWRIPVILQCIFLIPMLFIIMVLPETPRWLVSHNRPEEALEVLRRLNKGKMSDAVIERSHQDIVNTVAYEASIGSGSWSDLLKDDEIQSRKRFLIACGIQAFQQLGGINALIYYSSTLFQSSLNFSSNMSALMAGILNTWFFVASFIPWFLIDRVGRKPLFLSMISLMAAVMVVQTGLIYNVEKKTAIASACGAGAAAMLFIFQGAFTIGFQATVWVYPSEILPLKLRQRGSSISTACNWIFNFMIVYITPPAIRNIGYRTYIIFAVLNATWVPIIWLFFPETKGLALEDVDRLFAKSEDAQRQMSIIDHDDDDSGKGGVEQIDVAGHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PN31</accession>
    <name>N1PN31_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_34790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PN31"/>
    <dbReference type="STRING" id="675120.N1PN31"/>
    <dbReference type="eggNOG" id="KOG1591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058132_0_1_1"/>
    <dbReference type="OMA" id="NIWTHER"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF242">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME44323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="189" mass="21331" checksum="AFE1920704975B18" modified="2013-06-26" version="1">MDPKLIPIVRSPNLARSMVAAKNGTEMFSSERSSRTAYIPKDDPVAKCIYDRVSAFQGYEPLENIESLQVTAYQQDQQYRDHFDWFGPKANVTKDRITTFFGVLEADCDNCGTNFPDLPVSWDGQDERWCRFVDCTASSVTVLPVPGSALFWKNLHSDGTGDRRMRHAGLPLTRGTKTGLNIWTTQEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNU1</accession>
    <name>N1PNU1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_71755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNU1"/>
    <dbReference type="HOGENOM" id="CLU_2133453_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="113" mass="12106" checksum="514951113F96FC42" modified="2013-06-26" version="1">MVEHRAPSSMPPISTAAGIRQGKLVNTWSADGERLRDSLPLNVRTTLPLANACSSFAIAASALSLPGGGSCTNSSRRHNRQRRVQQNPRVTSQNGSSRILQSVVAKTRPKGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNU4</accession>
    <name>N1PNU4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_34991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNU4"/>
    <dbReference type="STRING" id="675120.N1PNU4"/>
    <dbReference type="HOGENOM" id="CLU_2250073_0_0_1"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="10928" checksum="8182B4D2C48ED0D9" modified="2013-06-26" version="1">MSPSNTTMILVPGAWHTADCFTSLSEECGIWLHDRSRHPASVGHEERLPNFSPDIDAIRSSIQGAANAGANVVLVGHFYGSIPSSEARQGLLKKDAAAGQGGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNX4</accession>
    <name>N1PNX4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_149947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNX4"/>
    <dbReference type="STRING" id="675120.N1PNX4"/>
    <dbReference type="eggNOG" id="ENOG502QRIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_5_0_1"/>
    <dbReference type="OMA" id="EWPLNTP"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME45111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="515" mass="56957" checksum="DB8C94A6168D95ED" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PPH7</accession>
    <name>N1PPH7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_88524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PPH7"/>
    <dbReference type="STRING" id="675120.N1PPH7"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009958_6_5_1"/>
    <dbReference type="OMA" id="VHICREL"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF81">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="66825" checksum="62C125C50B34FB21" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQ74</accession>
    <name>N1PQ74_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol 2-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_52820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQ74"/>
    <dbReference type="STRING" id="675120.N1PQ74"/>
    <dbReference type="eggNOG" id="KOG2742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_0_1_1"/>
    <dbReference type="OMA" id="GAPLMMH"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01671">
        <property type="entry name" value="IolG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050424">
        <property type="entry name" value="Gfo-Idh-MocA_inositol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023794">
        <property type="entry name" value="MI/DCI_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43593:SF1">
        <property type="entry name" value="INOSITOL 2-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="5">
        <location>
            <begin position="131"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME45581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37192" checksum="C5EB8E34ED85C4A4" modified="2013-06-26" version="1">MAARIGIIGLGMIGRDHLHRFEKVIVNAKVTAVCDINPAVANSVAQDHHATPYTDAASMIQSSEVDAIFICSIGEAHKDAILVAMEVGKPIFCEKPLAPTAEEAQEVIDLELKHGSRILQLGFMRRFDPGYLALKQTIDSGALGEIVLMHCAHRNAVMPGHFTQEKIINDSATHEIDMIRFLLNENIVSVRVDKPRKKTHRAPAGMQDPLIAIFETESGIRVDDTLYVNCNYGYDIRCEVLGEDSTAELNEQALISTRTKAGSSARIAETCMERFATAYDREVQNFVDNVYNERPMTGPSSWDGFVVAVVCDAALKSLRDGERHDVILPRTPELYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQC7</accession>
    <name>N1PQC7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_80278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQC7"/>
    <dbReference type="HOGENOM" id="CLU_653864_0_0_1"/>
    <dbReference type="OrthoDB" id="10547940at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME44614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="420" mass="47145" checksum="34CCC071819365D8" modified="2013-06-26" version="1">MLRENSVLQGAMTRPTLTNHHQRLHPQLPDEITLNVLGNASAMTLLALRHTSRRLRRTVDGESPRLCRILRESEDARIEAMWRPLELKGVSMEQALRVRVKRWGKPVQGRYWRACMSLAGEYGAANPHMCRHVFQDSLFEFLLHFDDSCHEQLPEVVEDGSERIKKRCCWSEYRAVELSQGELTTEMASELLYLFRGRRDKAAPPPIEERGLIGMIASVRSHRLEHDRTSVAEKARLHAQWRNVVVHGAKSCSTASRGGTELQLPMIWSPFCWLPKADRSSDGGSIVRQSKAVAITKWLLHRAQMSSCWSECDEHVSIMRVALLQELDVFRPEDAQHMQLSVRTRSGNEIMILVSAEAHLRVPVMSTSLLIAPTTSKPCLLARTGSVSANTGPIGPLDGTGAHDAGVVLMPTAKRPTEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQT7</accession>
    <name>N1PQT7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_103637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQT7"/>
    <dbReference type="STRING" id="675120.N1PQT7"/>
    <dbReference type="eggNOG" id="ENOG502SU3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_4_0_1"/>
    <dbReference type="OMA" id="GAPYATF"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME44784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="147" mass="15964" checksum="F1BF4B608B6CCD13" modified="2013-06-26" version="1" fragment="single">RGTCACGTTTWTSTTAPTHLDYCYCTQCQRISGSPFIAWLGLPHTSVSVQGSIKTFRLLVSSGMNSIATRSCCADCGSTLSMQYDCYKGEKVHIAAGTVVEGEIGDGVGRCHIWIGDKPGWYDVAGDGGERWEGFDEGFAERVRRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRD2</accession>
    <name>N1PRD2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_70881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRD2"/>
    <dbReference type="STRING" id="675120.N1PRD2"/>
    <dbReference type="eggNOG" id="ENOG502QTWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017593_0_0_1"/>
    <dbReference type="OMA" id="HHADHIN"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="145"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="448"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="637"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME44979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="826" mass="92228" checksum="C11E4D8B5CFFE9BB" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRI7</accession>
    <name>N1PRI7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate esterase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_60756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRI7"/>
    <dbReference type="STRING" id="675120.N1PRI7"/>
    <dbReference type="eggNOG" id="ENOG502S0SQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015101_4_2_1"/>
    <dbReference type="OMA" id="PNWVGFL"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF85">
        <property type="entry name" value="A, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="321" mass="36048" checksum="8EAC030467656EE9" modified="2013-06-26" version="1">MANRTTRPWWRLCPISLKLHIDYWPGWSGISHMFVFGDSYTTTGFEVNGTQPSAANPFGNPPYPGYTSSNGPNWIDFLTTTWNQSFVETINLAYGGATVDGALIPPYLPTVLSVRQQVNDDYLPSYATHPETFDWRSKDTLFAIFIGINDVGNAYGWSNSTVVFDKVLTEYAGLVDKLYQSGAKNFLFLEVPPVDRSPLTQAAGSSAQSIEKEAIASWNDRVAHIAQNLSTTHQDATTFVFDTNALFTQVLNKPSSYKETSPYKNTTGYCEAYENGTPSWYTKYDNCTYAVDEYFWLNTLHPTFRMHNVTAKQIAKQLSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTE0</accession>
    <name>N1PTE0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_22771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTE0"/>
    <dbReference type="HOGENOM" id="CLU_2263660_0_0_1"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="103" mass="11830" checksum="A71D009EA600B8BF" modified="2013-06-26" version="1">MGEIVFLVLCWANDRRPFGYKPLLGAPEVDLAMFQSMYGKPGSPLLVAPREMTRLERIQRTKRRAEHWVKKERLALRAKAASAVLYCKEKYDSAALAVEIFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTQ8</accession>
    <name>N1PTQ8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 115 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_22422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTQ8"/>
    <dbReference type="STRING" id="675120.N1PTQ8"/>
    <dbReference type="eggNOG" id="ENOG502QTU7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1555217_0_0_1"/>
    <dbReference type="OrthoDB" id="4849794at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842:SF2">
        <property type="entry name" value="GYLCOSYL HYDROLASE 115 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="172" mass="17771" checksum="F55A212450D71CC8" modified="2013-06-26" version="1">MSRRTFGESLVPSISTQNSSMILNVGGRSTFVSSSNGTTAGGTTIAGTIGASVVIDRSVTEGKVDINTINGTWEAYVPMIVTGPVPGVAEATKLAEGAKRAKSYEGVLTRGMRGCGDTALASGIEKEVLQYVVAAPIEILTDLWGNESVTYPDIVAHCGAGTKKCQGTTKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTU3</accession>
    <name>N1PTU3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_52967</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTU3"/>
    <dbReference type="eggNOG" id="ENOG502SKG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_6_2_1"/>
    <dbReference type="OMA" id="FGQDIWE"/>
    <dbReference type="OrthoDB" id="5378633at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109600" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="20"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME45785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="427" mass="48141" checksum="3D45D325B02D57E1" modified="2013-06-26" version="1">MLPLSALWLLPLAIPAVPALETRNTVNQTALLQLPECTVTCATQVLGPANCTMTDSCFCTDLVIEESIKFCLARSCPIDDQFAAQRFRARTCGWPVRNDAAVVDGISWGLFVVASAFVAMRMVSRMREFKGAGFWWDDYSLLPPYALSVAMVPVTHYVVHYGFGQDIWELRAAEVRKCLIWFYITEPLYITITFGSKISLLLLYLRTWPDQQLRVFRTTCCSMIILISLSIIAIDSAMIFQCTPVDLAWSLDIPREAANCTDRPTQVIVIAAINILFDLIVITLPMPRLLRLEIGWKSKIGLVFVFSIGVIDTICSCIRIKYMSIFGASENLTWDYTPIGIWSLVEIYLSITCACAPATAGLLKRAWNYASGRYTTVTEYERQKSGSRYEHDHDPGLKRAMTAETWVELQEQKGNSDCRKNVRRDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTZ9</accession>
    <name>N1PTZ9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_78352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTZ9"/>
    <dbReference type="STRING" id="675120.N1PTZ9"/>
    <dbReference type="eggNOG" id="ENOG502SYJI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_295429_0_0_1"/>
    <dbReference type="OMA" id="SKIPRTW"/>
    <dbReference type="OrthoDB" id="3946221at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1098" mass="122926" checksum="C8797421A11FD56F" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUA8</accession>
    <name>N1PUA8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_22069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUA8"/>
    <dbReference type="HOGENOM" id="CLU_139874_0_0_1"/>
    <dbReference type="OMA" id="FHITGME"/>
    <dbReference type="OrthoDB" id="3899120at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17889" checksum="62713F3633CD5219" modified="2013-06-26" version="1">MHSNTLPTPSSDKDCGEPIAARLERVSSAVVTAINARDFGFTSESAQELLAHIDPQWKAQIDTYAHQQQLLSWPQQVEMWRKRSVDFPDVHFHITGMETNFVNKGQGAATVYMNRKVTGVSDVVLHAAMNELRWRKTNNQWLCYYTIGLRGSPGNSGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PV03</accession>
    <name>N1PV03_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_148279</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PV03"/>
    <dbReference type="STRING" id="675120.N1PV03"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="OMA" id="DKDIQHA"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF112">
        <property type="entry name" value="L-ORNITHINE-N5-MONOOXYGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME46239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="537" mass="60245" checksum="1A6286463F5F86B5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVD1</accession>
    <name>N1PVD1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Core protein II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_69303</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVD1"/>
    <dbReference type="STRING" id="675120.N1PVD1"/>
    <dbReference type="eggNOG" id="KOG2583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_0_1_1"/>
    <dbReference type="OMA" id="APKFALY"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="44"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="195"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME47327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="452" mass="48602" checksum="AB06C8E24AC2DBB4" modified="2013-06-26" version="1">MIARSAISRQAQRAVRQPWQQSRNYAAATGSLAYETNKLNGINVASRDQPGAVSTLAIVAKAGTRYEPVPGLAEALQRYAFKTTERRSTLRIQRESELLGSELLRDHTRENLVVGAKFLRDDLPYFVELLAEVVSMTKYQQHIVNEEVIPVMQLNSKKHIGNTLSLATDSAHGLAFHRGLGMAEKPTSSVFTKYVTADALTEYAGAAYAKPNFAIIGNGVEQSALTKWVGEFFTGVSEQPSYQIKSEQSKYYGGEERIAHGSGNSMVLAFPGSSSATGSFYKPEVAVLAALLGGETSIKWAPGFSLLAKAAAETPLLHVSTKSLIYTDAGLLTIGLNGTASDIRTTAPKIVDALKGAAQNVSEDDFNKAKALAKFKELEFASGTHAAIEYTGAGLIRDGKPYQISEVASSLDGVTLDKVKQIAKEALENKASVSTVGDLYQLPYAEEIGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVQ6</accession>
    <name>N1PVQ6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2 type master regulator of conidiophore development brlA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_21334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVQ6"/>
    <dbReference type="STRING" id="675120.N1PVQ6"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_544193_0_0_1"/>
    <dbReference type="OMA" id="PDNTGDH"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="371"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME47561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="488" mass="54307" checksum="AACF28195E2D1934" modified="2013-06-26" version="1">MSCSTTPARPGRGVAVPGIDTRGPAEKALAFSGWPLTPPQSAHDSRRPSLAYSALSDVSHSGPPPISGYSQPATPVHGMAQSQDFTAQWTDGIDLHASMPVNMNDSCRNAHLVQPMSGISLQRQHITDAQPIPTYSSIVQDNFALTTPASPARNAWTPVQQPPSSFTANTVLSSAQDRSPAAGYHNVDQSYHSPFAHPGYPQCESTQALAPSVFQQPQHVVPSQVNAQWDYTMEPDAGYGAVEPMHEGYMQSFDSTSSGFSNFYSVPPASPADAYFDESDPDFVQVKNEYLSSPARGTPMSRSRHLLGAYDPQRISRKGSRCSKRSRKSQHEGKAWFEQEINGTLVRCEGKQFEIKDRVVLTLESKDSKPHRCTFEDEFGKICDRRFERSEHLKRHMGMHSKERGYPCPLPGCNKAFSRPDNTGDHFKTHLKSQPKGRRNPRFTFQVLERKILETYDEKTATKLLNNLRKWIANNPLLLQNEHIHAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PVZ3</accession>
    <name>N1PVZ3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_50930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PVZ3"/>
    <dbReference type="eggNOG" id="ENOG502SXCK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787981_0_0_1"/>
    <dbReference type="OrthoDB" id="3625478at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051344">
        <property type="entry name" value="Vgb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40274">
        <property type="entry name" value="VIRGINIAMYCIN B LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40274:SF3">
        <property type="entry name" value="VIRGINIAMYCIN B LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME47552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="303" mass="33078" checksum="54A31C52F08625A0" modified="2013-06-26" version="1">MSIHLHRGISSIHPLSTQLERTTKWSLHVLPSPNTLSSTCDFSNGPDGALWGEANVKNNIFRVDTKTGAADEYPIPPPHPSATRLYKASMTTKFKIEQHSPARSEKAQMAISTPAMPPENPLGDLQPSNDLYTAEDGIWLTQTTGNVLLFFSFRTETIKIHPVVIPLALPLGLFVASDGVVFVAVLQAKKILTCHPKMAEKNGFVYFALFTGNGNGRIEMKRIPLYSGDSGQNDDRLARLDTKALKYSYVDFPNTDALIGLPGTLSPLPPYIDVAVNCGPGDAIYFTNVSGNRLGRYSLSGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW59</accession>
    <name>N1PW59_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CT20 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_145626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW59"/>
    <dbReference type="STRING" id="675120.N1PW59"/>
    <dbReference type="eggNOG" id="KOG4051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075878_0_0_1"/>
    <dbReference type="OMA" id="QHTRIPY"/>
    <dbReference type="OrthoDB" id="5595141at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME47193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34069" checksum="01860F61016B130D" modified="2013-06-26" version="1">MPPRKKARVSQATSPDPEPPQKTPTPGFASPGKGDEAVLNDPWTDDEEIGLFKGLMRWKPTGMHKHFRLMALHSWLLENNYIHPRSQHTKPAGIWAKLNALYDLPALDAREDARQLSPLPTSPEQKEKVDGKESNDDADIYSLAANKIDSEDFALPPEHDFESMMWKARLAVENEDSELEIPEVNMAEEPPVRFTPSFSIEPSEAATTPQSKRGKKGKARGGAAPAQPRRSSRMTESVKDQDEEVEEDAEKSAEEEPEDEEEEDEESPDEAESQASTPDPRRGRSTRPTRGKGTGRGRGRGRGRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PW73</accession>
    <name>N1PW73_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_69231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PW73"/>
    <dbReference type="STRING" id="675120.N1PW73"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_1_1"/>
    <dbReference type="OMA" id="ERTGCEQ"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME47218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="302" mass="32043" checksum="1268A2CB90920386" modified="2013-06-26" version="1">MAPTNKVTDLFRVDGMVVVITGGGSGLGLYAARALDANGAKAVYIVGRREETLKSAAKTGVNGTIKYIVGDVTDKASLRKVADQVKQEQGFINLLFANSGVTGPKYEPEVGSKLSVKQFADALLEPAAEEYTQVQHVNVTGVFLSALTFLELLDAGNKKRNVPQDSQILVTSSIAGFSRQLGGSFAYSTSKAGVTHLIKMLATTFAQQGYRIRANIIAPGLYPSEMTQAGVSKLDNFGTPDGHRAFEGAHVLPKERSPSERTGSEEDFAATVLFYASRAGAYLNGVALVTDGGRLSQLPATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWJ1</accession>
    <name>N1PWJ1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_52156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWJ1"/>
    <dbReference type="STRING" id="675120.N1PWJ1"/>
    <dbReference type="ESTHER" id="mycp1-n1pwj1">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_14_4_1"/>
    <dbReference type="OMA" id="ISYNMMS"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF5">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="8"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME46755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="546" mass="59830" checksum="A68F430861E4129E" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXN0</accession>
    <name>N1PXN0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_104043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXN0"/>
    <dbReference type="STRING" id="675120.N1PXN0"/>
    <dbReference type="eggNOG" id="ENOG502QWBR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040566_0_0_1"/>
    <dbReference type="OMA" id="FFYHNNS"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF5">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="1">
        <location>
            <begin position="58"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="327" mass="35421" checksum="FC020134C6CFA7FE" modified="2013-06-26" version="1" fragment="single">SCPCGYAINATDSEHRATFTEALESDFLHTSNLTTDVVWIPQAYNVTPLAARGPCGKASQIENVIPNPIANPYDWTGEGTHGGDPGMQLWVKHDLIPSPSNSSQSIVPMSEIVSARTDILYGTFRIAVKTTAISGTCAAFFFYLSDSREIDMEFLSKQQQPARPGHSSSPAGGAVNLVLQSPQSAEVGYVDPSSPDFALQDLAFKPQEGYHEYRFDWLPDRVEFYADGTVLQTMRENVPSQAGAVHLSHWSNGNAGWSGGPPREDAVMVVSYVKAYFNSSIDGVGEKSLGECGQGEEVCQVPDQRTAPELSGMEGNRTGHTMFFGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXQ5</accession>
    <name>N1PXQ5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M43 pregnancy-associated plasma-A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_21524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXQ5"/>
    <dbReference type="STRING" id="675120.N1PXQ5"/>
    <dbReference type="HOGENOM" id="CLU_2073083_0_0_1"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12505" checksum="E921C14090D81767" modified="2013-06-26" version="1">MNSALHQASYSGLNLYFTSGLPSGLLRFCYFPVASPILDDLVLDGCMCLAASLPNGTATHYDLGYTAVHETGHWFGLYHVFQGLKALKLATMSTTRPYKGGDGGMPEGKGQLSGSDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PY97</accession>
    <name>N1PY97_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA biogenesis protein RRP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ribosomal RNA-processing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_147032</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PY97"/>
    <dbReference type="eggNOG" id="KOG1070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000845_0_0_1"/>
    <dbReference type="OMA" id="GQYLRAY"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05702">
        <property type="entry name" value="S1_Rrp5_repeat_hs11_sc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05703">
        <property type="entry name" value="S1_Rrp5_repeat_hs12_sc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05698">
        <property type="entry name" value="S1_Rrp5_repeat_hs6_sc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05706">
        <property type="entry name" value="S1_Rrp5_repeat_sc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000155">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000159">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000196">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000266">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000278">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000279">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048058">
        <property type="entry name" value="Rrp5_S1_rpt_hs11_sc8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="144"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="256"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="438"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="528"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="623"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="711"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="806"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="912"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1020"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1107"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1201"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1290"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1367"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1467"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1367"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1414"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1476"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME47963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1780" mass="196072" checksum="ACCBF862F5E070AC" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYD5</accession>
    <name>N1PYD5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_69808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYD5"/>
    <dbReference type="STRING" id="675120.N1PYD5"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OMA" id="LWNYLDY"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF3">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="82"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="235"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME47993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="546" mass="59565" checksum="D5F0D37649B9BDC1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>N1PZS3</accession>
    <name>N1PZS3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_69725</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <title>The Genomes of the Fungal Plant Pathogens Cladosporium fulvum and Dothistroma septosporum Reveal Adaptation to Different Hosts and Lifestyles but also Signatures of Common Ancestry.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Okmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H.A."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">NZE10</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PZS3"/>
    <dbReference type="STRING" id="675120.N1PZS3"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019048_3_0_1"/>
    <dbReference type="OMA" id="IWFRSPT"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="136"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME47890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="566" mass="61748" checksum="9C26AE81903449E2" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0F2</accession>
    <name>N1Q0F2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_68124</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0F2"/>
    <dbReference type="STRING" id="675120.N1Q0F2"/>
    <dbReference type="eggNOG" id="KOG2412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018821_1_0_1"/>
    <dbReference type="OMA" id="ILWAKYR"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="98"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME49251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="559" mass="62306" checksum="8C9F4AE691828A04" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0N0</accession>
    <name>N1Q0N0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytoskeletal adapter protein sagA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DOTSEDRAFT_69948</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1Q0N0"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002006_0_0_1"/>
    <dbReference type="OMA" id="AMYLVRQ"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="14">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="14">
        <location>
            <begin position="154"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="14">
        <location>
            <begin position="307"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="340"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="13">
        <location>
            <begin position="1351"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="379"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="697"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="760"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="850"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1213"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1297"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="458"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="731"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="850"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="967"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="992"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1073"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1222"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EME48175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1391" mass="146294" checksum="7FEA05C47E0FBEAA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0Y1</accession>
    <name>N1Q0Y1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear protein DGCR14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_70033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0Y1"/>
    <dbReference type="STRING" id="675120.N1Q0Y1"/>
    <dbReference type="eggNOG" id="KOG2627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024820_0_0_1"/>
    <dbReference type="OMA" id="AQNDYLD"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME48295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="52606" checksum="E196267D31D7070D" modified="2013-06-26" version="1">MASSSDSQALAKRNAETALMPPPPAPKRQRRPAKVLDEDVYSDAISHIIARDFFPGLLETEAQSEYMEALDSKNNDWIREAGRKLTQVMTPVPEGQRRTGRGIGTGFTSRGSTALGDTPRTFVGETPSRTPIDNDHFAEETTPKVEVNMSLGAFQAKYTSEDNESFNALLDKQNDKRAAKYGFFHQGNKIPTARQIAYREHQQKLIEDGFGSTSTALIAANAAGDERRSLAAAGPSEDLDARPASVDSFRDRQGPRNHFMFGPDGVEDWTITRAQQAELSSNAPPKAVKYSATRFSADASNPEYIIPASPSLSAVDAAIAGRSKLSHSESGYSGAETPQVNGYAFVDAEPTLSELGIPVTDEEADAAEQEAVKQLLPKADQSGPNPFNISERSKRENLHLRLVEKADASRRKGGRLDHLRDLGIKPGRTPTPKFASGANIRRSGGMTPAAQRLADKIGTPKRAGGMFGSERADMASWTPTPRVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0Y3</accession>
    <name>N1Q0Y3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_163794</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0Y3"/>
    <dbReference type="STRING" id="675120.N1Q0Y3"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002678_91_1_1"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="439"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME49431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="583" mass="65060" checksum="18B270F7BCFC339D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q164</accession>
    <name>N1Q164_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_67899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q164"/>
    <dbReference type="HOGENOM" id="CLU_2904160_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME49008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="62" mass="6488" checksum="1E22D2CC30C9ACCC" modified="2013-06-26" version="1">MLGMTLLAGHIVPLASLNHHPIEVRTKGHDKLVDLSGMSGGNLGIAVDPKGNDPEVMQFSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1A5</accession>
    <name>N1Q1A5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_70011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1A5"/>
    <dbReference type="STRING" id="675120.N1Q1A5"/>
    <dbReference type="eggNOG" id="ENOG502SP01">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535302_0_0_1"/>
    <dbReference type="OMA" id="MSWILMI"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="537" mass="59364" checksum="D17D58337E191E64" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1L5</accession>
    <name>N1Q1L5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_68381</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lipid hydrolase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1L5"/>
    <dbReference type="STRING" id="675120.N1Q1L5"/>
    <dbReference type="eggNOG" id="KOG2214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009031_2_1_1"/>
    <dbReference type="OMA" id="CSWFTRG"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990748">
        <property type="term" value="P:cellular detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006642">
        <property type="term" value="P:triglyceride mobilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 6 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="9">
        <location>
            <begin position="312"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="731"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="785"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="6">
        <location>
            <begin position="343"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="731"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME49582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="817" mass="93068" checksum="950DB5FC663A531C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q1Z2</accession>
    <name>N1Q1Z2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bud22 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_68463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q1Z2"/>
    <dbReference type="STRING" id="675120.N1Q1Z2"/>
    <dbReference type="eggNOG" id="ENOG502S6Z4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029647_0_0_1"/>
    <dbReference type="OMA" id="ALWEKKF"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="32"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME49697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="443" mass="48169" checksum="5A8F5851DEAEE62C" modified="2013-06-26" version="1">MSKRKRDSDADEDDAPVATDFRQQRQIAATFEDSAKQLARAFKAGKGFERQKLGRRKKNAVAAKDEKDVERIDAEVAALKTLDNTLAAEHYLAKSLLKIKAVATSPNLPPDLHKPKPLASDTASLNVNARLCNSNPVKEAFPTAIAAVKREFGIKEDSKAPAKKRRARAKDYENSNRGRSVSVDCEGDGGLRVASLLRLRAQDISEDETGAHDSSEDSGDDLGQYRGRLGSSDDEDLDGVSDIADLERRLMAEGISQKTGTSKAGNYGHGATVSLSEVSDDESEVEQRPKKAVAPKKSSFIPSLTMGGYISGSGSDLESDVDVAPKKNRRGQRARQKIWEQKYGSRATHLQNEQRKQGWDPKRGAVDSDRGGRFGKNKGNGANSMALGKDRRVAGQSDSIAEAKQKPRKDDSGPLHPSWEAAKRAKEKKAAPVAFQGKKISFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2C5</accession>
    <name>N1Q2C5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_40082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2C5"/>
    <dbReference type="STRING" id="675120.N1Q2C5"/>
    <dbReference type="eggNOG" id="ENOG502S2AR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008243_1_0_1"/>
    <dbReference type="OMA" id="PMDINQK"/>
    <dbReference type="OrthoDB" id="9368434at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME48795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="768" mass="84380" checksum="F95E0F386D0F0D35" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2N5</accession>
    <name>N1Q2N5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_68692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2N5"/>
    <dbReference type="eggNOG" id="ENOG502T2RY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094265_0_0_1"/>
    <dbReference type="OMA" id="YPAWYNA"/>
    <dbReference type="OrthoDB" id="5419608at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110392" evidence="3">
        <location>
            <begin position="17"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME49957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="184" mass="18148" checksum="EEC88EFF7F85B64F" modified="2013-06-26" version="1">MQYTFFLSALVATVLAQNNQKQDGQASESVAGLVSVISVLQTALPSTLVQEALTNSAVVAADISSQFAAGSTPAWFTALPSDVQTYLVPSQLYPNATAEGTLISATPINSANATGAGNSTRSSTSRRSTITNTATGTGETSLETGSSVSKGGSSSSSSAGASMPSAIVGIGLAGAVGLVGVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2R7</accession>
    <name>N1Q2R7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_50139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2R7"/>
    <dbReference type="STRING" id="675120.N1Q2R7"/>
    <dbReference type="eggNOG" id="KOG1694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066767_2_1_1"/>
    <dbReference type="OMA" id="KWYNADD"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME49987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22745" checksum="A32089DE096EAB27" modified="2013-06-26" version="1">MSSEQPQTKKFQKGERLITPAAQKASKYYPAEDVSAPKTTRKALRPYKPRQSLKPGTVLILLAGRFRGKRVVLLNVLEQGTLLVTGPFKVNGVPLRRVNARYVIATKTTVPLDGLDAATVKKASGEKYFARDKKADKKGSEEAFFKQASGEKPEKKQISSERAEDQKKIDKALLSVIKKEPLLQGYLSTNFSLRKGDKPHEMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2S7</accession>
    <name>N1Q2S7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2S7"/>
    <dbReference type="STRING" id="675120.N1Q2S7"/>
    <dbReference type="eggNOG" id="KOG4018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084528_0_1_1"/>
    <dbReference type="OMA" id="QWDEHKK"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031333">
        <property type="term" value="P:negative regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000075">
        <property type="entry name" value="RWD domain-containing protein (Gir2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME49538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="232" mass="26758" checksum="AA10BAB21B783952" modified="2013-06-26" version="1">MGREEQREERDVLDSIFPDEIQDINESEYRVTINLDPPLDEDEDHEGPVIILNVRYPEAYPDEAPYLDVSQPPNAPKHKYLDIQQDKAYLLETLLPTIEESMGMAMVFTLVSTLKDAAELLISERAQAVQAQKDFEAAKAEEEENRKFEGEKVTRETFLAWREKFRQEMKEEAERKQAEQEAEDKKRRGGKADEKKLTGRQLWEQGLAGKTVDEDEEGEDAVESLKQLKVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3C2</accession>
    <name>N1Q3C2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_20650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3C2"/>
    <dbReference type="HOGENOM" id="CLU_811400_0_0_1"/>
    <dbReference type="OMA" id="QYDADFQ"/>
    <dbReference type="OrthoDB" id="3644357at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME50281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="342" mass="38008" checksum="C4658FEA27580A11" modified="2013-06-26" version="1">MAPNRKAIPPHLQRKIDRPAASVPSSDNECALVLSPAHAEDEPPAPSGPNSIISASIKHNFTPTELVQQDVIDTLRSQVEDLTMRCDRLDEENAHLRVTLAKLAHLLKGSALGGSRAPNLVGYESSDDGIASNDHAEGGPSSTYANQIAVILTRHEDRLADLEARSTNMEINGLQVINGKSQHTTSDVKAPGGTSGEDGLLTHRLESLEQIVESGLRQTNKYHIELQDLQIWRSNINDEQGSKALKTTSAPAPQYDADFQARTERKSKQELHVDMTFSRDELFQHYQELSELIQDYRDDGNFQGTDDELWSLRERVITNIAILDQREKALEGIKEWMKYNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3L9</accession>
    <name>N1Q3L9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_68974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3L9"/>
    <dbReference type="HOGENOM" id="CLU_1077783_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME50282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="258" mass="28342" checksum="F24EE6843CDDF4B2" modified="2013-06-26" version="1">MDAGSVFEPGEAGDALTSNVTTDSARITNLEQRVSALELRDSTVEKDAPDSLIQHLESLGTSILDLGLSHPSYQKMATSFLAIVNEYGKSDDADPWSALGVIKFKLEEQQKRPEFNHSKHESESFDGWAATPAPTSSRGWEGSPLQTARAADSFVFSDFSDKNGQAYGGRGGPTTKRQTNGWGASPSPTLPASAKQHKSDLPRDYCFDVRDFNVKSEYGPDLCRPRQTRRRTYCFLCGFSGHNEKDCHLEASKRTPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q412</accession>
    <name>N1Q412_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_122074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q412"/>
    <dbReference type="STRING" id="675120.N1Q412"/>
    <dbReference type="eggNOG" id="KOG3181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_2_0_1"/>
    <dbReference type="OMA" id="NKKKWMI"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME49978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="266" mass="28943" checksum="FB4234C4B2F76D8A" modified="2013-06-26" version="1">MSGLNISKRRKFVADGVFYAELNEFFQRELAEEGYSGVEVRVTPTVTDIIIRATHTQEVLGEQGRRIRELTSLITHRFRFPPDSVSLYAAKVQSRGLSAVAQCESLRYKLLNGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPAKDFIDHATRHVLLRQGVLGIKVKIMRASSSPGDPSGEKAGGKGLPDSVTIIEPKEEQPILAPSSQDYGAKAAQAAQYAQQQQQAQGEEGGAEGEAPAAQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q468</accession>
    <name>N1Q468_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_164998</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q468"/>
    <dbReference type="STRING" id="675120.N1Q468"/>
    <dbReference type="eggNOG" id="KOG2094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_11_2_1"/>
    <dbReference type="OMA" id="EVYTRQV"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000003">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000014">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000010">
        <property type="entry name" value="DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000012">
        <property type="entry name" value="Putative DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="8">
        <location>
            <begin position="132"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="593"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME50053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="640" mass="72572" checksum="C0A1836E880E5004" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4K5</accession>
    <name>N1Q4K5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_68502</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4K5"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OMA" id="PSNRYRI"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000313">
        <property type="entry name" value="MFS quinate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME49745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="543" mass="59891" checksum="5E8A7B52C61CE319" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4U4</accession>
    <name>N1Q4U4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_68641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4U4"/>
    <dbReference type="STRING" id="675120.N1Q4U4"/>
    <dbReference type="eggNOG" id="KOG2358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060555_0_0_1"/>
    <dbReference type="OMA" id="AIMEHYM"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME49900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="265" mass="28914" checksum="9685917CDC3627C6" modified="2013-06-26" version="1">MQRLSQPAARQALPFAQAKRTIFIQTEDTPNADALKFMPNHEVIPDTVPSTFLEYLSPRSTLAPPHPSPLAANLMNVDGVTSVFYGKDYITVTKDSSTPWAHVKPEVFSLITEAVTNGQPLVNTVENKTGEEGQGSAVSAAEATYDPEDEEVVGMITELLDTRIRPAIQEDGGDIEFRGFHDGQVLLKLRGACRTCDSSTVTLKNGIESMLMHYVEEVKGVQQVMDQEEEIAMQEFAKFEEKLKAQKGEAPPTSPGPASIDHVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2WKB1</accession>
    <name>M2WKB1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_28556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WKB1"/>
    <dbReference type="HOGENOM" id="CLU_1981557_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="126" mass="14609" checksum="43CD138BBD684221" modified="2013-05-01" version="1">MELDDYAMAYTIGDVAGIALIFQQLISWDDMRFVDDRSARWQKEYTPPVGHQAGQRHSTFGSIDKTPLFQDNPKLFMGQTAWQGGRDTWPLVRYDEPRCLHDGATHWRAPGLRYWGWADMVTKMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2WKE2</accession>
    <name>M2WKE2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_28586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WKE2"/>
    <dbReference type="HOGENOM" id="CLU_1283223_0_0_1"/>
    <dbReference type="OMA" id="CRNDGKA"/>
    <dbReference type="OrthoDB" id="10528526at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="215" mass="23858" checksum="11D7B8AA891C479D" modified="2013-05-01" version="1">MFTTTEAYRLAIASLFAKRPVTLSQAMPGLDITAKPSEHDLFESSAPIVRLPPHKIGNSMPLPQPSILLSRPPPPGEPLQTHEELAQWKHPFGYFVTIPRTGLFNELCYTVGETSRSMLRKASAVAQKGFPIAEMQGDNVGTVKLKGIGAVEESDLRTLKDDHRSSSTTDSEVDDSEAEAWSKYDVLRRRDEEDTLIGEDGDWSMYPDSDSSDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2WM80</accession>
    <name>M2WM80_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WM80"/>
    <dbReference type="STRING" id="675120.M2WM80"/>
    <dbReference type="eggNOG" id="ENOG502SSMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1234789_0_0_1"/>
    <dbReference type="OMA" id="ICAKNRM"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="219" mass="23390" checksum="237F3D0D4BFCA8BB" modified="2013-05-01" version="1">MAQQPVLVKAYDDGRPSAVPGPIIPGTIVTLPPISSFAFDDILRTVDSPELQNAIEGIAEICAKNRMSLADEYASHLPPLGEITATNSRNLRSHTMRHSGGIRRALTSVPEGSSGSSEGSRKSKKKASIFSFRKQQTQESKPMRRIRIGSMGRMIPVGTTTAIAADNIDLSLQEHTRNSSQSTITPATAARPTSRARSTSAAVSSLQRLLGLGRNAQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>M2XGF7</accession>
    <name>M2XGF7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_141174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XGF7"/>
    <dbReference type="STRING" id="675120.M2XGF7"/>
    <dbReference type="eggNOG" id="ENOG502R8UN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1402397_0_0_1"/>
    <dbReference type="OMA" id="DFKVVFC"/>
    <dbReference type="OrthoDB" id="3838727at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004029427" evidence="1">
        <location>
            <begin position="18"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="194" mass="20887" checksum="0E208C83B92DEE41" modified="2013-05-01" version="1">MYTIGLALIMLTTFAAAAPKYVAPLFPRGQTDDFNLHVYNNCPFSKSVALYQVTGGFQMLEKSVPITLAADGGHTVIKAPYKDLGMRLSGHAEWGADGQWKAQALFKFGYGDYMGSKGTAYNLSVMEGSDADIGIGAYPTANGNGSGTCASKTCFPCDCPLNQGWTNPDQIYVDSPADTFCYYGENDFKVVFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>M2XH57</accession>
    <name>M2XH57_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_48307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XH57"/>
    <dbReference type="HOGENOM" id="CLU_1959526_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="128" mass="14267" checksum="36594C12901FABA0" modified="2013-05-01" version="1">MTGRGGRIQARGDNRVTDTMVDLTGRLKATVGWQPESLPTNHVPQITLSNMRHRTDSYGCNMACHMSFQNSRTLAPQLSTSFLNHVRNLQCGTMCLHHTRVLGISTHSTSRPATRLRRTFAPASPQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2XHK7</accession>
    <name>M2XHK7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_39128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XHK7"/>
    <dbReference type="HOGENOM" id="CLU_1906678_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="133" mass="14293" checksum="B96483AF853D3D48" modified="2013-05-01" version="1">MDNDLDNVPGICDSILNITVMAEMVGAESVSCLRNAKDGAGIEPPRLGVLMYLTSGCMIIEGRPYVGTAGVPDKVFKSFQEVQVKKVIRVKLRIGGSTWLDAVGVWDKTVMAIGMSRLSPHAFLCSTVLPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2XIA9</accession>
    <name>M2XIA9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ino eighty subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_75066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XIA9"/>
    <dbReference type="STRING" id="675120.M2XIA9"/>
    <dbReference type="eggNOG" id="ENOG502QVDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007606_1_2_1"/>
    <dbReference type="OMA" id="TPNMRIN"/>
    <dbReference type="OrthoDB" id="5413003at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038014">
        <property type="entry name" value="Ies1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287:SF1">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME39207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="846" mass="94239" checksum="A4060198929C4884" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>M2XJN4</accession>
    <name>M2XJN4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_75352</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XJN4"/>
    <dbReference type="STRING" id="675120.M2XJN4"/>
    <dbReference type="eggNOG" id="KOG2026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016848_2_1_1"/>
    <dbReference type="OMA" id="QLRRFKC"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="12">
        <location>
            <begin position="84"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="206"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME39672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="61708" checksum="6B27939EC0CE8794" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2XLN5</accession>
    <name>M2XLN5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_174162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XLN5"/>
    <dbReference type="STRING" id="675120.M2XLN5"/>
    <dbReference type="eggNOG" id="ENOG502QQW3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045794_0_0_1"/>
    <dbReference type="OMA" id="IAQHFFT"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000554">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43832">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43832:SF1">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="40109" checksum="4DA8621963C4C7BB" modified="2013-05-01" version="1">MNYDALVETVVDGGYLPEFLLRQGIRSQLRQRIELISSTSLADSYDTKMKYVDLLRTQPIAVETAAANEQHYEVGTGVLSACLGPRMKYSCCLYPKGTETLAQAEIAMLESYVEKAQVKDGMRIFDLGCGWGSLSLYLAEVLPKSQITAFSNSRTQKEYIDSQAQQKGLTNLEVVTGDIASYDFRETSLEEQFDRVLSIELFEHMKNYELLLAKVATLLKPSGKLFVHYFAHKSSPYDFESGWMTTHFFTGGTMPSADLLHFFQRDLKLERQWWVSGKHYAKTCEDWLSKMNASKKQIWPHLEETYGKTDTAKWFHRWQVFYLACAELFAWNGGEEWGVCHYLFEKPAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M2XZB1</accession>
    <name>M2XZB1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_92600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XZB1"/>
    <dbReference type="STRING" id="675120.M2XZB1"/>
    <dbReference type="eggNOG" id="KOG2493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_3_0_1"/>
    <dbReference type="OMA" id="YDNETEH"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF57">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME38033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="518" mass="56201" checksum="DC1B399B84D619A0" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y192</accession>
    <name>M2Y192_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_67004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME39074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y192"/>
    <dbReference type="STRING" id="675120.M2Y192"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="OMA" id="VRGICGF"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="19"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME39074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="451" mass="48353" checksum="5F7A914098ADEBDC" modified="2013-05-01" version="1">MEEQTGKIKASRKFGSIITILGSALANLSDGYQQSLASSTNVIFKHLLGSKVYTSDVQTRISNALLVGSVIGILLFGFVADKFSRKGGMLVTSALVIVGSLMSVLAFQVYASSGAHDMLWYLTIARGAAGVGVGGEYPTSAAAALEGSNEHFDSQRGPIQVLISTLMATSGSALCTLTYLLALIGSHNGLRVAFHAMYSVSTILPVIVILTRWRMQDGKLFARSNFQNRRIPWILLIKQYWVRIIGTSSAFFLYDFVNFPNSIMSSVIINGLVPGKNVRTVALWQLYLALMPIPGVLIGAWLVNRIGRRWTGILGFIGGYVICGFIIGGLYHKLTTDALPAFVVLYGLLQAFGHLGPGATIGLISCEAFPTPARGMGYGIAAAFGKAGAAVGTQVFTPIREAAGPASTFYVAGAIGILASGIYYFLPEGNRLELERADEEFERLLRNEALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y4T5</accession>
    <name>M2Y4T5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="9">GAT</shortName>
                <ecNumber evidence="9">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">Ornithine acetyltransferase</fullName>
                <shortName evidence="9">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="9">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="9">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">N-acetylglutamate synthase</fullName>
                <shortName evidence="9">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="9">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_174069</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="9"/>
    <dbReference type="EC" id="2.3.1.1" evidence="9"/>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y4T5"/>
    <dbReference type="STRING" id="675120.M2Y4T5"/>
    <dbReference type="eggNOG" id="KOG2786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027172_1_0_1"/>
    <dbReference type="OMA" id="WGRIVMA"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.340:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003802">
        <property type="entry name" value="PRK05388.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023544507" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023544506" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="9">
        <location>
            <begin position="236"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="9">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="9">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="9">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME43299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="505" mass="54468" checksum="74FC4312A28A3D5D" modified="2013-05-01" version="1">MAPKGSSAAKRLLAAAIQQVRSYSAPADRSIPATKQKYIPTSGTYPKGFLAGSAFAGVKATNTKYDDLALVVSEAPCPAAGVFTKNVFKAAPVQTSSKFLSERKGHGFRGVVVNSGCANAVTGRLGLEHAATMARTTDQCFGSAESDAVPSTLVMSTGVIGQRLPIDRITNAIPKLHQSLGSSHDHWMNAAQAICTTDTFPKLISRTFTLPSHPGTTYSIAGMTKGAGMIHPNMATLLGIVCTDAKVDPKSMRYFLRHVTSTSFNCISIDGDTSTNDTVNFFANGAAAPANAAPLRYHGDKQSRSNASLEDQDDTRAFIKILSKFFKDLSQLVVRDGEGATKFVSIRVRSDLNYATAKRAAVSIARSALVKTALYGKDANWGRILCAIGYAPGIMDSQELPLRNLVPTNLENQRPIYPVKPRRTSVSFIPADGTEELKLLLRGEPEQVDEVRAKQILEAEDLEILVRLEDDGETAPSGDKKVHEAVFWTCDFSHEYVTINGDYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y5Q1</accession>
    <name>M2Y5Q1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_54348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y5Q1"/>
    <dbReference type="STRING" id="675120.M2Y5Q1"/>
    <dbReference type="eggNOG" id="ENOG502SJTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004083_7_3_1"/>
    <dbReference type="OMA" id="GYVQWHS"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF77">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME43574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="736" mass="83704" checksum="F29E6CA4F0ECBB22" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>M2YL56</accession>
    <name>M2YL56_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DOTSEDRAFT_75367</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YL56"/>
    <dbReference type="STRING" id="675120.M2YL56"/>
    <dbReference type="eggNOG" id="KOG0595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006447_0_0_1"/>
    <dbReference type="OMA" id="INNVVQW"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000817">
        <property type="entry name" value="Serine/threonine-protein kinase ATG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="30"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="342"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="471"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="558"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="961"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="839"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="983"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EME39691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="999" mass="110275" checksum="5E29D2FF418A854C" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>M2YN58</accession>
    <name>M2YN58_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_72703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YN58"/>
    <dbReference type="STRING" id="675120.M2YN58"/>
    <dbReference type="eggNOG" id="KOG0183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_0_1"/>
    <dbReference type="OMA" id="ICMLDHH"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="279" mass="30046" checksum="6E1F6BA7047645FB" modified="2013-05-01" version="1">MSGYDRALSVFSPDGHVFQVEYALEAVKRGTCAVAVKGSHPEESVVVLGCEKRSALKLQDTRITPSKISMVDNHVCLAFAGLNADARILVDKARLEAQSHRLTVEDPVSIEYITKYVAGVQQRYTQSGGVRPFGISTLIVGYDPGSKEPRLYQTEPSGIYTAWKANAIGRSSKTVREFLERNHKDSMTRAETIELTIKSLLEVVQTGAKNIEIAIMAPGKNVEMLPSDDIEKIVEKINTEKDAAAEANANRRGGARAAGGSQGSEQVLASRPAGEGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>M2YP77</accession>
    <name>M2YP77_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_131144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YP77"/>
    <dbReference type="STRING" id="675120.M2YP77"/>
    <dbReference type="eggNOG" id="ENOG502S4RI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407477at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="207" mass="23787" checksum="226D8C4E23D5DF43" modified="2013-05-01" version="1" fragment="single">IALKHGTDKVTRHHYHHIYQKYLEHYRPKPLKLLEIGLGCDMEYGPGASYYTWLEYFPYVDLYYIEYDADCAKKWAHKTTGATIFSGDQANVTFLHEFLETVGMDFDVIVDDGGHLMHQQITSLEVLWKAVKKGGLYFCEDLQTSWWDNAGGDRANTGTKKTMVGMIKELVDDLTVETGGHARKHKVSEDMLFVDCMEEVCAFTKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>M2YPC1</accession>
    <name>M2YPC1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_174315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YPC1"/>
    <dbReference type="STRING" id="675120.M2YPC1"/>
    <dbReference type="eggNOG" id="ENOG502RZVZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079143_2_0_1"/>
    <dbReference type="OMA" id="DINFTHG"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="34"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME43471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="212" mass="24949" checksum="48560B4DC48F62E0" modified="2013-05-01" version="1">MAPEPEKDAQGIEEWKKRAPYRIHEPNEHFKHRYEASCHCGKVEYELSREEPLDSKLCHCTTCQTQHAAPFQWAAIFKKDDINFKNGHHNLEWYDPSTKSVEHKLPCKVRCSYCHSPIMDEGRNMILLFPTLIHFKSDKDKENFKPRMHMFYGQRVIDIPDGLPKWTGLNQGEGSELIEDSPPDMIRDLERRRVEEQKNRSSFEKGTHKEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBZ2</accession>
    <name>N1PBZ2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_75894</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBZ2"/>
    <dbReference type="STRING" id="675120.N1PBZ2"/>
    <dbReference type="eggNOG" id="KOG0424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_12_0_1"/>
    <dbReference type="OMA" id="TWECGIP"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106068">
        <property type="term" value="C:SUMO ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061656">
        <property type="term" value="F:SUMO conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME38521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="157" mass="17860" checksum="23FE76FC26ABDB00" modified="2013-06-26" version="1">MSLTVARLQEERKQWRKDHPFGFVARPVKSAQGALDLKKWDCAIPGKDKTIWEGGLFKLEVQFPDEYPTKPPKCKFVPPLFHPNVYPSGTVCLSILNEEEGWKPAITIKEILLGIQMLLDEVNPDSPAQADAYNLFKKDRAAYEKRIKQVVKDNPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBZ4</accession>
    <name>N1PBZ4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_57407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBZ4"/>
    <dbReference type="eggNOG" id="ENOG502T0Y1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1008908_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="275" mass="30696" checksum="EBCA77CD51C9F402" modified="2013-06-26" version="1">MPTRIDDRYLWLGFGVFFFFAAKGIRHAITNTVRLTELDPISTRSDEDESRQPEDRIAISTLKTLALSPNPSIASSAASLIVTRFASLPDAAEIISTDLYSKDEDTRRRAKQAIAYLQDWDTTLSTSLDETRTFAAREALVEAARTLRSPHPSTPHLPTLAEMQSVANVAGGLVSVSDLDREAERQRDRQLDVVSRLEEMAEIGWSNEELEQGSARFAGWDRIPNERDDGDDGDVYDLRRELAERRRRRRVMVVSTEDEEESGGGIGGAGWRAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC79</accession>
    <name>N1PC79_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_74791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC79"/>
    <dbReference type="HOGENOM" id="CLU_2399653_0_0_1"/>
    <dbReference type="OrthoDB" id="10491045at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01167">
        <property type="entry name" value="LPXTG_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109638" evidence="2">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="93" mass="10009" checksum="D5822BC468D4C6B2" modified="2013-06-26" version="1">MLVNLLLLTSCLASTSRADDSDPHTGHDVGVTLGVVGGCAVVALIFLVARKKHLFVQITPGLGETYGQGKTARQSEQQGMERFIEMLDARPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD91</accession>
    <name>N1PD91_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_27984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD91"/>
    <dbReference type="HOGENOM" id="CLU_1610710_0_0_1"/>
    <dbReference type="OMA" id="HEHETIT"/>
    <dbReference type="OrthoDB" id="10491028at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="165" mass="18686" checksum="DC12DD3414258DDC" modified="2013-06-26" version="1">MGNKLSTEEPQHVKTLKSKPNVRKEPAFQYHSAGWREGEFDDDAEEFSLATCKEPPGYDNDDEHEHETITNHRPDRHVSEDGFPSLELQRSHLEVPSSSRQDRAGKERKRPPIEDRCSQAQDDGDAFEACEARRHNVGAVAIQKENVWRQEEIAAHNASSETAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDA2</accession>
    <name>N1PDA2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_136549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDA2"/>
    <dbReference type="STRING" id="675120.N1PDA2"/>
    <dbReference type="HOGENOM" id="CLU_2418982_0_0_1"/>
    <dbReference type="OMA" id="RNICFIA"/>
    <dbReference type="OrthoDB" id="539398at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336:SF1">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="92" mass="10260" checksum="31D7AFE62B7229A8" modified="2013-06-26" version="1" fragment="single">RRNICFIASASLNGKHIDSSPKGQPSATLAIFSSALVGYLDATGLGIETFSHIHENGRARFTSRSFSKSPRIRGWFCEARVIQKEHPDYETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDC3</accession>
    <name>N1PDC3_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_38317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDC3"/>
    <dbReference type="HOGENOM" id="CLU_1586430_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="168" mass="18044" checksum="62D47723522B9CED" modified="2013-06-26" version="1">MATTRRPARNNTPPRLEADAFEWRQCRVESTLHSPESSFSTGLVLALLVISTLPAAGEGRSVPATLPAGTPRHPHHHQHPAVGIASLRFDNYGPVALPAGTLDGRVSLQSMVRTNTLGRVCCAWCRPVPEERRPQEACTASSNAPLAAGADRSLLPSKGRENCQRVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDT9</accession>
    <name>N1PDT9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_37350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDT9"/>
    <dbReference type="HOGENOM" id="CLU_1731428_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="151" mass="16931" checksum="F0D662822F8745CF" modified="2013-06-26" version="1">MARDDTFDVKMEDLNRRLGIGKALCDRSEWFRWACWGPLKASECEYLVRCLTDCATHLSAVAVWDLEDFDTPEENLAQAITVAYTATCDPNRLLRDEIVKVMLNKGELLKGGNEHFDKISEAAPTFAADMIKAPAKDRHDQRAASAAEPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDV8</accession>
    <name>N1PDV8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ureidoglycolate hydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_74604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDV8"/>
    <dbReference type="STRING" id="675120.N1PDV8"/>
    <dbReference type="eggNOG" id="ENOG502S1JQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070848_0_0_1"/>
    <dbReference type="OMA" id="DCQEVAF"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="UREIDOGLYCOLATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221:SF1">
        <property type="entry name" value="UREIDOGLYCOLATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME39755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35353" checksum="8106C19EB1A7BC08" modified="2013-06-26" version="1">MAPATLKTEGSISSPSILASSSLNSIDFAPFGEVLENPATHPDHGETKLKNVIANQGTATKWLDVTHMENWYTMAPSRKPAKSVVNMFVCKSRKLEDMEGRRVFPVKVLERHPFTPQTFIPLGVSAEDNATRYLIIVAPTLKSTQRDRDDRQQPYPAERPKRARSLKDRLLGARPNPFTNDHIPTTTPSPADLGRERRPKGPGEPDLQNIRAFIARGDQAVTYGPGTWHAPMVVLGNKDIDFVVVQYANGVGIEDCQEVDVREDIAVDVNDSGDKQGASIESEQSLFAHNSYGVEQGKTKSEKTKSEDEASKLGYMRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE62</accession>
    <name>N1PE62_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_27820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE62"/>
    <dbReference type="STRING" id="675120.N1PE62"/>
    <dbReference type="HOGENOM" id="CLU_1695418_0_0_1"/>
    <dbReference type="OMA" id="ISEPMIS"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="155" mass="17235" checksum="F7C77244BE231717" modified="2013-06-26" version="1">MATKIDVLRLLAVNRQAFWSITLKNSADLMKTIVNEVWYPAIQPLMKVEGFVGALVFQPLTEPIIEHFAKNGDNGLGMDYTGGPLVTVDLDFQWNSTSGDDQILSIEEDIIAKSKTCAESRGLSHRYIDQNYACIKRDVFAGCGPQSKARLLKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>N1PEA6</accession>
    <name>N1PEA6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_74707</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PEA6"/>
    <dbReference type="STRING" id="675120.N1PEA6"/>
    <dbReference type="eggNOG" id="KOG4012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052897_0_0_1"/>
    <dbReference type="OMA" id="MISECIA"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME39925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="231" mass="23905" checksum="580B2CB9A51BCB3F" modified="2013-06-26" version="1">MPPKKSTTTAKTATKKDAPAHPSYADMIKEAVISLKERNGSSRQAVKKYVLANNSLGSTTDAQFTAQFNKALLRGSENGTFTRPKGASGPIKLAAPKSADSKVAAKTTTKKAPAEKKTAAKKTTTAKKPAAKKATATKTAATKKAPAKKTAAKATTKKTTPKAKANTGKARKTPAAAPAVEEKAPVVLGKTKSGRVTKSTAPQAEKKAAKPRKSAATKKATPKKTKTPTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PES2</accession>
    <name>N1PES2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione transferase omega-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_179032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PES2"/>
    <dbReference type="STRING" id="675120.N1PES2"/>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_9_1_1"/>
    <dbReference type="OMA" id="PDADIHP"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF13">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE OMEGA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="113"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME40095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30867" checksum="36E7B06EEFDF627C" modified="2013-06-26" version="1">MSAHPDADLHPVATGPAKAIVDAHQTEQPLKLYSGWFCPFVQRVWTVLEEKNIPYQYIEVNPYNKPKSLLDLNPRGLVPTLQYDNKPLFESTVVCEFLEEAYPDHGPHLLPKDPYDRARTRIWTDFCTSRIIPAFHRFLQFQPMSDTEGLGRVREEFLGKWKELTKEMDPTGPFFFGEEPSLIDFVIAPWVVRLWIFDHFKEGLDMGKGQEWNRLRVWMTALEERPSIKNTTSEREHYLPIYQRYADDKAQSELAKATRSGRGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF62</accession>
    <name>N1PF62_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar pre-ribosomal-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_110593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME41027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF62"/>
    <dbReference type="STRING" id="675120.N1PF62"/>
    <dbReference type="eggNOG" id="KOG1791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009575_0_0_1"/>
    <dbReference type="OMA" id="RYITFKR"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="1">
        <location>
            <begin position="72"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="3">
        <location>
            <begin position="604"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="2">
        <location>
            <begin position="852"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME41027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1083" mass="122240" checksum="745933B958413EDA" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1PF71</accession>
    <name>N1PF71_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_74878</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PF71"/>
    <dbReference type="STRING" id="675120.N1PF71"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_0_3_1"/>
    <dbReference type="OMA" id="PRFIANT"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME40210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="520" mass="58771" checksum="04B69306CFD16070" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFF6</accession>
    <name>N1PFF6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="10">DOHH</shortName>
            <ecNumber evidence="10">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LIA1</name>
        <name evidence="12" type="ORF">DOTSEDRAFT_74408</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="10"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFF6"/>
    <dbReference type="STRING" id="675120.N1PFF6"/>
    <dbReference type="eggNOG" id="KOG0567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053974_0_0_1"/>
    <dbReference type="OMA" id="LQEPCSI"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="250"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME40834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="329" mass="35471" checksum="15383E78F726002A" modified="2013-06-26" version="1">MSPSRVEVDDTVPQLRRVLGDESANLAARFRALFSLKHLAALNPATEQTVPAIEAIAAALTSPSALLKHELAYCLGQSGKAEAIPFLRAIIEDRLEDAMVRHEAAEAIGALGDQGSLRLLKERRDDKSEADVVKETCEIAVERIEWEHSDAGKKEKLKQSDFVSIDPAPPMAQAADKSSIPELGRTLLDVALPLFKRYRAMFALRDLASPPDLPTAVPAVDALAAGFKDPSALFRHEIAFVFGQLGHPASIPSLTECLSDTKEASMVRHEAAEALGSLGDEEGVDDTLKKFLNDPDQVVRDSIVVALDMAEFEKSGETEYATVPVPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFT5</accession>
    <name>N1PFT5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_74133</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFT5"/>
    <dbReference type="STRING" id="675120.N1PFT5"/>
    <dbReference type="eggNOG" id="KOG2005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008705_1_0_1"/>
    <dbReference type="OMA" id="GTCNGDI"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905754">
        <property type="term" value="C:ascospore-type prospore nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="62"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="863"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME40455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="919" mass="102183" checksum="42FD3BDB3F34A762" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGE3</accession>
    <name>N1PGE3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_176960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGE3"/>
    <dbReference type="STRING" id="675120.N1PGE3"/>
    <dbReference type="eggNOG" id="ENOG502S59M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045993_0_0_1"/>
    <dbReference type="OMA" id="CKNKECQ"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME41678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="290" mass="31725" checksum="C4FE140C7FF62591" modified="2013-06-26" version="1">MSGNYRVEIAKQGRAGCTATDCKKEEIKIGKGEIRVGVTVVFQEHTTWKWRHWGCVTPTMLHNWKEKTEGDEEMIDGLEEIPGEIQEKVKRALENEHVDDDDWKGDAEMNRYNPDKKMQGMFVKKSAKSKKKEDDDDEDDDDDAPKKPAPKKRGRKAAHEDDGAADEAPAPKKARGKKVKAEDDETAEPPATKKPRGKKAKAEDAADAKGAAPAPVKKKGRQPKASKPTEPSDDAEPEPAEEPKAALKKGRGKKTVASAPPDVPDEPAPKAVTKRPGRSKKAAAVAKDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGP8</accession>
    <name>N1PGP8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_26914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGP8"/>
    <dbReference type="HOGENOM" id="CLU_1517829_0_0_1"/>
    <dbReference type="OrthoDB" id="10568748at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="177" mass="18936" checksum="B0040210D7B19A42" modified="2013-06-26" version="1">MDHRMNIFVGATVVSIVCSATLLATTATRMNTPVYIAWLTTSLAFFCMGVCFAASIYLRAQTLNIDARTSLNADNADAHDNTAVSAGIEDPRNTYSLSTFYWCSPGLQNTTASVSASRTPETLNHQPLQGSSGPQSAAMLSSPSSPGLPPAAYFISSVVDLQRVVRVTQPLPTYQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH02</accession>
    <name>N1PH02_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_176530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH02"/>
    <dbReference type="STRING" id="675120.N1PH02"/>
    <dbReference type="eggNOG" id="ENOG502QU3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004291_2_0_1"/>
    <dbReference type="OMA" id="VARIYWQ"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="685"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="719"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME41414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="855" mass="95089" checksum="0229EE1915D6B9C6" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH30</accession>
    <name>N1PH30_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP citrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-citrate (pro-S-)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Citrate cleavage enzyme subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DOTSEDRAFT_74229</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="2"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH30"/>
    <dbReference type="STRING" id="675120.N1PH30"/>
    <dbReference type="eggNOG" id="KOG1254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006587_4_1_1"/>
    <dbReference type="OMA" id="HMLRYQA"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA-binding" evidence="18">
        <location>
            <begin position="46"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EME40611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="668" mass="72376" checksum="6FF97A0F2948547D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PH72</accession>
    <name>N1PH72_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Versicolorin reductase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dothistromin biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_135187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PH72"/>
    <dbReference type="STRING" id="675120.N1PH72"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="EPNNEPY"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME41489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="268" mass="28974" checksum="6300322DD5DD2DA6" modified="2013-06-26" version="1">MASKAFLITGAGRGIGRGLSRLLLEKGHRVVLVDYNQRELHHTADKLGQTFKDGQDFAAIECDLRDPHHIRGVAEAARSFFAGNLDCLINNAANTSGVGGSHLSELSLEDWNNSIETNLTAPMLMSQACLSMLQSQGSRSAGGSIINMSSTRARMSEPNNEPYSATKAGLLGLTQSMAVSLGELGIRVNAILPGWINVSNECKEADDEGQSWEEGLNKNDHEWHLTGRVGKVEDVLRAVEYLVDSEFATGEEMVVDGGVTRKMVYPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHX6</accession>
    <name>N1PHX6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger ZPR1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_74471</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHX6"/>
    <dbReference type="STRING" id="675120.N1PHX6"/>
    <dbReference type="eggNOG" id="KOG2703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024138_5_0_1"/>
    <dbReference type="OMA" id="FREVVIM"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000003">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="44"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="282"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="467"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME40926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="495" mass="54485" checksum="7E37BF3246546BF4" modified="2013-06-26" version="1">MAQDGNGTQPNGSKPLAQDLFEDMGRKVDQTNGEAHKVVEEIESLCMNCHEDGITKLLLTKIPFFREVVIMSFACDHCGHQSNEIQSAGEIQPKGSRYALKVEKDEDLQRQVVKSDVCLFRIEDIDLEIPAGKGQYTNIEGIMNAVRDDLSQHQEARMEQMPEVGVKVAAIITSLTDMLEGRKYPFMISADDPSGNSSIEPRPGDAAGKWAKSEYNRTPAQNGMLGLGEDVPNPASEAPQTELRPEYHSSNLVGADSVPAVQGNNVDMEEDIVEDQVYSFPASCPGCTRPCATNMKMVNIPYFKQVVLMSTVCDHCGYRSNEVKTGGEVPEKGRRITLKVSTAEDLARDILKSESASLFCPELQLRVEPGTMGGRFTTVEGIMTQIRRDLRAQAFGLEDGDAAVPEGAGDSMTTDSKKLWEDFFASLTDAIEGYKEFTLTLEDPLAGSYVQSLTAPEPDPKIELQEYERTKEEEEDLGLADIKTEGYEEVEEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PHZ0</accession>
    <name>N1PHZ0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_46224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PHZ0"/>
    <dbReference type="STRING" id="675120.N1PHZ0"/>
    <dbReference type="eggNOG" id="ENOG502QVWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027816_4_2_1"/>
    <dbReference type="OMA" id="AGMFWLH"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="68"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME41160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="478" mass="51312" checksum="BE5AB32608BBC574" modified="2013-06-26" version="1">MLGSSRSDVHPLTNMSKTEDYGYNSYEAGGQDSPQHGRGGGGGGGGGEYDESRDVFGHEEHHDIKYKTLSWQIVSVLMIAEIVSNGMLSLPSSLATVGMVPGLVLIIFLGVFAAYTSVLLVRFKLRHPEVHNMGDAGKIMFGWVGREVFSFGTIAFAFLLAGGQMLSGQIALSSLSNNGLCNVSFTGIFAAATFLCALPRTFDNLGFVSIASVMSIIVAGVVGMVGAGIHPVAGRSVVAARSSDFYTAFFSITNPVFAYCGHFMFFALMSEMKRPQDAIKAAYTLQGVATTYYAIFAGVTYGFLGSAVLSPSFSSLESVWAKAAYGIALPNLLIAGSLYVHTASKIIFIRLFRNSRHLHDHTVLGWGVWVFLVALFSGIAFVFAVGVPIFNYLIGITASLFAAWFTYGIAGMFWLYDSYHDGDGTRSWRRRWPGTLMAVLTIIVGLFICVAGLYVTIRAIVDAYASGTITAPFSCGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PID9</accession>
    <name>N1PID9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PID9"/>
    <dbReference type="HOGENOM" id="CLU_2622013_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="78" mass="8046" checksum="08C307BFB9B90529" modified="2013-06-26" version="1">MHFANTHPKAAPVLIGDQSPMLFASTIDIPPTTSDTGSLRSPPQAPQLNPLITPAYILSSAPSTASATRCSLSSPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIH9</accession>
    <name>N1PIH9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_55191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIH9"/>
    <dbReference type="STRING" id="675120.N1PIH9"/>
    <dbReference type="eggNOG" id="ENOG502T6GN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_276591_0_0_1"/>
    <dbReference type="OMA" id="KLIARRW"/>
    <dbReference type="OrthoDB" id="3644903at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055499">
        <property type="entry name" value="DUF7071"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23257">
        <property type="entry name" value="DUF7071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="789"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="641"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="866"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1015"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="866"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="911"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1024"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME41345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1150" mass="127120" checksum="62FA4CB4954DAC72" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIL1</accession>
    <name>N1PIL1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_175094</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIL1"/>
    <dbReference type="STRING" id="675120.N1PIL1"/>
    <dbReference type="eggNOG" id="KOG1341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005947_4_1_1"/>
    <dbReference type="OMA" id="RAHMLYF"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="611"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME42197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="73803" checksum="EE0A18CCC871C9D5" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIM4</accession>
    <name>N1PIM4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_36805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIM4"/>
    <dbReference type="HOGENOM" id="CLU_2145802_0_0_1"/>
    <dbReference type="OMA" id="YINGAGC"/>
    <dbReference type="OrthoDB" id="3959840at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109133" evidence="1">
        <location>
            <begin position="17"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="112" mass="11982" checksum="EC042C878236088F" modified="2013-06-26" version="1">MQLLTVLLGAIAAAGAAPIDTNRTLVSDSVVPTNITIEGRSEAMCLNCTSCKAKQDGIALKYIVRVGAPFGNGQDCDSVKKILQASNLPDNEKFHCRADKGDMTHLDFDAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIM9</accession>
    <name>N1PIM9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_176519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIM9"/>
    <dbReference type="STRING" id="675120.N1PIM9"/>
    <dbReference type="eggNOG" id="ENOG502S4FY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084247_0_1_1"/>
    <dbReference type="OMA" id="WMMAAKA"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="17"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME41405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="176" mass="20321" checksum="BC104C4A051ECC23" modified="2013-06-26" version="1">MTTPAIRSDPSLGPVWFWREFEIPYGFMSQWYESAFEVNGVTYQTAEMWMMIQKARLFGDEEIAEQMMQTTVPKEHQALGRKAKGFDRKKWDEHKSKIVEEGNYHKFTKGKASADMMRNLLATGERELVEASPADRIWGIGFGAADAEANRDKWGENRLGKAIMNVRERLRSEGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIU7</accession>
    <name>N1PIU7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_26108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIU7"/>
    <dbReference type="eggNOG" id="ENOG502RC8S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1695428_0_0_1"/>
    <dbReference type="OMA" id="HGEECAG"/>
    <dbReference type="OrthoDB" id="3650444at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="155" mass="16245" checksum="3BBF323CD94CE63E" modified="2013-06-26" version="1">MAVSADPFVTAHRLLEAGKPSPAESIQGLREQILANASALFPQLALRSPSFHTTGLSKPSELFEIITIGNIHKQALLLFGPPLARGIAARGPASKCVAAALAGLLDVLSEALSWYTETLLGELKHGEECAGGQVNFAMVEGGFHFSAGERLARGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ50</accession>
    <name>N1PJ50_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">NZE10</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <title>The Genomes of the Fungal Plant Pathogens Cladosporium fulvum and Dothistroma septosporum Reveal Adaptation to Different Hosts and Lifestyles but also Signatures of Common Ancestry.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Okmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H.A."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">NZE10</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ50"/>
    <dbReference type="HOGENOM" id="CLU_1234996_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME42608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="224" mass="24408" checksum="071A394E5AE7316F" modified="2013-06-26" version="1">MLLRLKKDIAKPSSLVLQSFPSHTLGSLKLKYSQLSDSDTCREPWTPDEASSPVQLRAAGNTALEILRVFANRSCYAPRNEMFSPGGIRAQSHDCSAEASTSYQYPTFIPANAGALAVTQALGGSHTLHHVAPAHVVGITSQRLSARRTTQTTTDSSGNPKVLSVDSKGHVRFVRWWLPPLLLDVPEDFIAVAQCYSLAEPLPEVFMSTSISTQCLSRKIRDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJP0</accession>
    <name>N1PJP0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJP0"/>
    <dbReference type="HOGENOM" id="CLU_1266866_0_0_1"/>
    <dbReference type="OMA" id="YWWERIV"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="218" mass="24952" checksum="637E3E8BEF66A91B" modified="2013-06-26" version="1">MASQLRRLVMNCTDAHDIGISDRHGEMVSAYWWERIVKSTTNLVELDICTGYRSYPATFDDERQGCKVMDHFLRHGHYCQLRKLEFRRSKHTGPTVVDSHVLKGFSTAHAKTLRHVSMSDILPPTGSVMNMSDVLLAYKSLLSASMPAIQILKVSLSRLDKHDDEKCYCVGNGYCQWYRFPICNLLARNFDELANYFEMELKDGSWDSGEIVMRGCQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK17</accession>
    <name>N1PK17_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_155716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK17"/>
    <dbReference type="STRING" id="675120.N1PK17"/>
    <dbReference type="eggNOG" id="ENOG502SIRY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017443_1_0_1"/>
    <dbReference type="OMA" id="AKHCHRA"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF9">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="213"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME42732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="613" mass="67915" checksum="972412AF32CABB08" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PK66</accession>
    <name>N1PK66_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_72908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME41960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PK66"/>
    <dbReference type="STRING" id="675120.N1PK66"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1208498_0_0_1"/>
    <dbReference type="OMA" id="QFTERAM"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME41960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="237" mass="26842" checksum="C36AB538DF4A6F03" modified="2013-06-26" version="1">MKDKWISSEILPNFQTDALNFMHKAQSVSEKLMLCFARGLGFPDDHFTKVHSTSRPDCQSVLRLLHYFQVDKDRGQLSSEYHRAGAHADWDLLTLLFQRPGQSGLEICPGREVVTSFGMGDTWTKVNFEEGDIVCNIGDLLMSWSDDRFKSTFHRVKAPTDPEKDYFGPRYSIAFFNQPCVDCEIQGPLKKYPKVTGADFTKAAMERNYNALKTKQTEIVSGRGSLHHVDIQVAANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PKT1</accession>
    <name>N1PKT1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_34615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PKT1"/>
    <dbReference type="HOGENOM" id="CLU_1189899_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="233" mass="25986" checksum="2179CFB4955EF72E" modified="2013-06-26" version="1">MAIEPVYNRFATRSESQALRAGKLVPCFHVLPPPPFGPAINPQSLADPDALQTLRDQLVLRSRLILDAVHQALLILTLPYQTLPRMVPSFLLLAYQSLLVLLTRLGSLSTEARKESCPYRTVPILSQLEERRRAGHASRPGHLRNSPSHALKPAAGDVRTRFQRSRELLLGHVRGAGCECYCSIFIWGVPLGSARMTGVQVPRLWGPSTLRMSARCPCSRLALEMLRYKAIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PLZ3</accession>
    <name>N1PLZ3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_133185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PLZ3"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="OMA" id="YSWMADL"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME42336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="54712" checksum="80C0B93EBCB04C8A" modified="2013-06-26" version="1">MTVSNSITRLWGSPSAERSLLIKLDFTILIYFSTIWFLFGINRSSYSTACKYGMKEDLGFEGKDYNYMSTIYLITYAIFQIPSTSLLTLTKPRYVFVAANTVWSVLTLVTYRVDKVWQVFVLNAFEGAFSAIAFVGAHFVYGSWYKQSELAARAAIFCGFGNLGNMAGGWIQAGLINALKGSPSALPAWRLIFIVVSCMTIPFAVFGWFAIPDLPQHRAARFLSEEEKELAATRLGKTAGNAWDWTVFRRVLLSWQFYLLPFVFMLYSLVVQALGNNVMPMWMASRGYSVVQQNTWPTAVHGTGIAATFLYCYISDKLRSRWQCSLAIGLTFIFSSAILVSSPKSDSAYFFAFYLLGTTYAPQALWYSWMADLTGHDLQLRAITTGFMNSFDFAFVTWWPLVFYPVTDAPNYRKGYIASLVTGCLTIPVIIIIALLERRGRQKGSIGRGASSPGESDEAPQLNHTEDDTVPKAFSGRQAGAVPSVVAISAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM26</accession>
    <name>N1PM26_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DOTSEDRAFT_71762</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM26"/>
    <dbReference type="STRING" id="675120.N1PM26"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036230_0_0_1"/>
    <dbReference type="OMA" id="SGHREIN"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043609">
        <property type="term" value="P:regulation of carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="222"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="341"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="517"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EME44063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="556" mass="60367" checksum="8EDFC241C378EF1D" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM59</accession>
    <name>N1PM59_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear segregation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_155167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM59"/>
    <dbReference type="STRING" id="675120.N1PM59"/>
    <dbReference type="eggNOG" id="ENOG502QRKP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023943_1_0_1"/>
    <dbReference type="OMA" id="AHWKEDQ"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME42416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="54946" checksum="76E70EFC840895B4" modified="2013-06-26" version="1">MAEVAETKAAPPAKPERPDEDEYKKNLAAAEKELKTAEDRMKQIKAKIDNARPQNKDSPAAKRQQDLRSELSGIRDQQKNSKSGRGQVMDKIKKLDEQLKTRIAESKAQRSKVQYKSADDVDAEIKKLQAQVDSGKLKIVDEKKALSDISQLNRLKKSFANFDDAQKGIDATKAEIAELKKQLDDPANKALSDRYTQITTELDSIKAEQDDAFKNLNALRDERTKVHEDQQKKYAAVKEIKDAYYQQRRAAVDYEREARRIREEKRKAENDAYHRGRRQEAAKSKLEEASAPAFQDEIRITQSLIAHFDPSFVKKQEASGPGKFAATDFRTVDASGIKGTALKSKKDDDDDAYFIGGGGKKKKGGRGAKVTGIASPAQEATSKFNLDLGTIDSLARINVDPPMSQADVPAVVEKLKSKLETWRKDQDKQTKENIAKAQAEIDRLEKEAAEADSGARTNGTDKTEKKVNGDAPVEDAAQQLGAASLEEKTVTEGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>N1PM61</accession>
    <name>N1PM61_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_34975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PM61"/>
    <dbReference type="HOGENOM" id="CLU_1695426_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="155" mass="16756" checksum="773F9B45FF9FD550" modified="2013-06-26" version="1">MYLSTPHSCPVNAFHYLLIHGRGATHSSFIPLVSALGLEECLQYTTSILYILVGHGDIYSTATPNFVLTTTMVTATLLIATSTLDLTNMGSQQIISVYSSLISSVNNDMAAQMSASMPRAMAQIIDVLWHASSYMSMGGIWQNSNMNVMIVMVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMA0</accession>
    <name>N1PMA0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_34901</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMA0"/>
    <dbReference type="STRING" id="675120.N1PMA0"/>
    <dbReference type="eggNOG" id="KOG2763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032862_1_0_1"/>
    <dbReference type="OMA" id="QFNYTFL"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000038">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="205"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME44486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="381" mass="42872" checksum="3BCFD07FFD749777" modified="2013-06-26" version="1">MSDSYHSVMLPLAQDPWLLDTYMNATGHIRIGTILMDLDALSGVVAYKHTGDGITTVTAACDRIVINHPLTEICDLEYSGKVTYASGRSSMEITLQVAKAAKEGEQTKPEDVMLTCQFTMVSLDPETRRPINIPAVRTDTEEEKQIYAQGEKNSLHRKELGKRSLLKQTPNDEESDLIHAIWQKQLQYHDPADPVRKPSNVHAMSKTQLNTATIMQPQYRNRHQFMIFGGYLLKQTFELAFCCAASFAHARPTFVSLDPSTFQNPVPVGSVLYLTATVVFTDPPMVASQSEDKSAEGQRAENSRTRVQVRVDSKVRDVEHGQAKPTGQFNYTFTVDKDIKVMPQTYTEFMMYVDARRRAKRVLESMQHGNTDSGTQDRVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PMM9</accession>
    <name>N1PMM9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PMM9"/>
    <dbReference type="STRING" id="675120.N1PMM9"/>
    <dbReference type="HOGENOM" id="CLU_1067714_0_0_1"/>
    <dbReference type="OMA" id="HADNCSA"/>
    <dbReference type="OrthoDB" id="3770080at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="203"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="261" mass="29624" checksum="C9C0EF061C68C815" modified="2013-06-26" version="1" fragment="single">MARLCHPCRALDLQRTDFTSAPWLPSERRNTNICVRTFASLIKSRSQCDLCDLIWHAFKRGDVDALSSVHSEDTWSLQWGQHTSDWQPDNETDGIEDEFGSALYPCFGEDGDRQDYGIQLVDEAGTGGFLRGRLISEHVDVGLLQAWIKRCKDQHGWRCRGSFLEPRDFDSTGLASLTVIDVERLCLHDLDKPELVTPWGPQYVALSYVWGSDNNVRTMKSNEARFRRPGGLDIDLPKTIADAIEVTRALGYPYLWIDSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNF6</accession>
    <name>N1PNF6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_172659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNF6"/>
    <dbReference type="STRING" id="675120.N1PNF6"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="OMA" id="WNISIGA"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF4">
        <property type="entry name" value="ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="627" mass="69273" checksum="C1DEAB6DD1024B09" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PNI1</accession>
    <name>N1PNI1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cryptic loci regulator 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_24083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME43979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PNI1"/>
    <dbReference type="STRING" id="675120.N1PNI1"/>
    <dbReference type="HOGENOM" id="CLU_621156_0_0_1"/>
    <dbReference type="OMA" id="NACPCHR"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="2">
        <location>
            <begin position="62"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME43979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="441" mass="49727" checksum="C13101AAB4C38863" modified="2013-06-26" version="1">MAARTIPGYAQVAIIAYTGPANGDATRKPSRDNYYQSDHYYRHALAQKLMKELGQAQPGTMYLLDKLPAGLTAWENQRPVLEGRRNSGTTDRFIYGHPGGPFETLDRAYDHIKFLLLHGAPSPTNPCPCHRCGKKRTKVETGVVRTCTPVPCPLVQITSVQVIPDHLRRLKLVDLIKALNNGDHLTAVVQQPQQVQQVPQVDQAQSTPMSQLFHQLYDTQQAQLTQQPRDFDLMQARRHQYTQQLWLLSQLRHHWQNGSTQQAKQRIQTRQTPWMRQAPYSLQVPSTPVAMPHPEVFYNQTVSSFTYQMQQQSVDWNREMVYPQLTAPSAQHAPSAQQVAASTSRTPQVPTRTTAFIHGLPDNIPWSPHSPIKREYSTEPGPAAPPSFRQPSQALGTKRNFEEQHGEEEDEATLIKRAKPDPAVDSATSGIEQCPSFSRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP60</accession>
    <name>N1PP60_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_44424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP60"/>
    <dbReference type="HOGENOM" id="CLU_1959535_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="128" mass="14117" checksum="A664464FC24DC161" modified="2013-06-26" version="1">MSREMVVLIEGLTSASKEFNVLRNLAAAPTAYSTTAADLTAKLHAMLEASLCWLYQGGSWLIYAPWQVLFNISSWHLKARSAGCGIPFHLSRSRLALCDSSRECPQHRLYAGICVTIEILARTDSDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PP81</accession>
    <name>N1PP81_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_129489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446539">
        <property type="protein sequence ID" value="EME44738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PP81"/>
    <dbReference type="STRING" id="675120.N1PP81"/>
    <dbReference type="eggNOG" id="ENOG502SI58">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018249_1_1_1"/>
    <dbReference type="OMA" id="MHEFNIM"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF8">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110012" description="ASST-domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME44738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="58974" checksum="AED4C68C20602C09" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQD0</accession>
    <name>N1PQD0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_33722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQD0"/>
    <dbReference type="STRING" id="675120.N1PQD0"/>
    <dbReference type="HOGENOM" id="CLU_1695423_0_0_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="155" mass="16957" checksum="CAAABE4975C12877" modified="2013-06-26" version="1">MGMRCGHNGVIFGCPSNNGKRYFLSATAFKYGPWKHDKWQRASDVEALKANFADWDECARRQVSLLPNDGGMMIWSIWAMHVVLHSQMKQSVRANTHQLQLSLSPKDESPSSEIAAHASTPCPCAGAGQSIEDVLILEQLLGTKLVATNSTGNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQG7</accession>
    <name>N1PQG7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_71046</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQG7"/>
    <dbReference type="STRING" id="675120.N1PQG7"/>
    <dbReference type="eggNOG" id="KOG0203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_4_1_1"/>
    <dbReference type="OMA" id="QQPPIFN"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="905"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="945"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1008"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1037"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1069"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="125"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME45193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="1109" mass="122736" checksum="D0A35D4FCF5093D9" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQM4</accession>
    <name>N1PQM4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_127788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQM4"/>
    <dbReference type="STRING" id="675120.N1PQM4"/>
    <dbReference type="eggNOG" id="ENOG502SP6B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024519_3_1_1"/>
    <dbReference type="OMA" id="WMALTFF"/>
    <dbReference type="OrthoDB" id="2129688at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME45751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47510" checksum="A2E7A4BA0893F83A" modified="2013-06-26" version="1">MSSRHDRFPEFKDGDVKLVVTGSRQYKLHSSVLRNNSEVMRELLDERDAAQLDRKAQKNGITTRFKLVLVENPLYPDGEEELSRIEYVFEAIPLNSNDQPAGNNLRGVGDGLENGRVVPEIFIAYEAVLGAFYNVPIQLGDAQSDGLTHLLSMALQITTVAEYLDCIHIITRPIEATLLATGQHLLKAIANNPPAWLSFAHRIKSKAIFRESLIHASGQYMYPTVQDAITSGDLPDEVTSLLKKKALIIIEAVRSCERHLASYYPTILMREKTVGRVDRDNIGRANYANDIIMWIALCIFRHWASDMMASDQTHHAKDLGFAFINAVAKGGDAYLAKTVLHDQFHLRFPMSPKGMACTEHRLAEIKEVVKQWTVPLMRNESHLDRKANPQHHFLFTTVKVTDYPWRDENGLDEEEEYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PQZ0</accession>
    <name>N1PQZ0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_150357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PQZ0"/>
    <dbReference type="STRING" id="675120.N1PQZ0"/>
    <dbReference type="eggNOG" id="ENOG502SV73">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104298_0_0_1"/>
    <dbReference type="OMA" id="HAVIHMK"/>
    <dbReference type="OrthoDB" id="3650189at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6590" evidence="1">
        <location>
            <begin position="21"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="163" mass="18348" checksum="733966087E0B0768" modified="2013-06-26" version="1" fragment="single">MFFGSDPESERLDPAYKKRSSSFFSRGKVFLTLWSEPTTREDPSTEVTRVRFGQTVFSRIRRFIVIKEGPAFCTAVQITTYTSQGVSKAGIKKSDHAIVHTGTDPPSPLPEEEAVHPHERMLQPPIRIDPVSPGDKLDALSRINYGKVYTIEHNLKVKPFGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRF4</accession>
    <name>N1PRF4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_43389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME44950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRF4"/>
    <dbReference type="eggNOG" id="ENOG502TFN5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_973606_0_0_1"/>
    <dbReference type="OMA" id="HRILHQW"/>
    <dbReference type="OrthoDB" id="3813486at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME44950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31253" checksum="1BC298046E2AB2EC" modified="2013-06-26" version="1">MANQHLNEASLLGLPRELRLEIYQHVFSLDISHRILHQWRDTHTAEQGFKSVPDLNEGPLSIPWLQLMLTCKTIALELRALMREPSFLEQHNNGTYTLDLEATRGGMTLGATTWRHIPCAPGQVRCLEAFYNASRGFQAWGVGGPHGITSGLYQTLNHFVHCGPRFDSAHILSIPMHLKELRVVVVERDFSGEEDDNASYRLSERDTDPRTTLYALGSIVGQIVRTGVLKGFVDDIHLSCDGEMLQWCPNSEDGTGIPEYWNRYGFDWGMELYKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRI4</accession>
    <name>N1PRI4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_70116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME45997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRI4"/>
    <dbReference type="STRING" id="675120.N1PRI4"/>
    <dbReference type="eggNOG" id="ENOG502SFKU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_3_2_1"/>
    <dbReference type="OMA" id="TPFIETW"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME45997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="139" mass="15701" checksum="FC0BB2D5F9A1E825" modified="2013-06-26" version="1">MSYNGKCHCGHHEWTVELKDDQQNHILCHCDTCKILGGGAFTMNQIIPKNQLKITKGGEPSKYTYYGDSGKGVNCYYCPKCTTHIYHHQEVMGPDTIIARTALLKDGRDKFDVGAEIYGKAKMKWEKEIAQTFETLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PRI9</accession>
    <name>N1PRI9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DOTSEDRAFT_168234</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PRI9"/>
    <dbReference type="STRING" id="675120.N1PRI9"/>
    <dbReference type="eggNOG" id="KOG0498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006113_0_0_1"/>
    <dbReference type="OMA" id="RMKSVWD"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000057">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF24">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G03170)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16643">
        <property type="entry name" value="cNMPbd_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="63"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="272"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="585"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="185"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="504"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="738"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="551"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EME46002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="992" mass="109171" checksum="21FC2F61C07D4E6B" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PSA7</accession>
    <name>N1PSA7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_23793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PSA7"/>
    <dbReference type="STRING" id="675120.N1PSA7"/>
    <dbReference type="eggNOG" id="ENOG502SE9M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_367610_0_0_1"/>
    <dbReference type="OMA" id="RRMERHK"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="758" mass="84049" checksum="D82F5401A141D45C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTK5</accession>
    <name>N1PTK5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_33337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTK5"/>
    <dbReference type="STRING" id="675120.N1PTK5"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721643_0_0_1"/>
    <dbReference type="OMA" id="INHIAVV"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="418" mass="46878" checksum="FA643F1E631C23D0" modified="2013-06-26" version="1">MDNAASSAALRRACDTPLPFQAGHWRFDCSCCLGTITDQALVIIHSDRICISCFQFGVKPQFIAALADESQFPVEWGGKEIELKHYRLCFTKDFRYAWKAKLQEYSVPPAKRFYCQGRVDTNTEKEICNKFLGRKRAGVSIEHCKECGCDSCAFCGSVVGSTDHICSGSNTTPEVDPFAELKRGVDYQRCPGCDMAVELRDGCNHITCRLGRCSQHFCFLCGLPATIEDGHWRAGKPCPLYHQPDAANAQYDAGIPDAAEVALIDRIRDEAEQDLILGRINHIAVVDIPDEIRERRAHRVELDGMLRAIENEVIDLVGLGLLAESWAERLEPFRQMHGYLDLLWKSLFAYTIKLETDEIIREGLTRLLDEIGQRIITSRATINPEMQARFPRAEEIFLQMAEAAMQLIPAEADAAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTP2</accession>
    <name>N1PTP2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Versicolorin reductase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Dothistromin biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_171377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTP2"/>
    <dbReference type="STRING" id="675120.N1PTP2"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OMA" id="WNIVFTG"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME45779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="281" mass="30043" checksum="60015A7DEF9249F4" modified="2013-06-26" version="1">MTATFPTYPDLKGKVALITGIGQVGRPDSDTWGNGAATARVLSHNGVKIVGCDLNLNAAHYTKKRLLQDNPEATIDVMSADMTSVQDIEAFVKAAFDKHGRIDILYNNVGMTAPGDPGTLSEEAWQKMLDLNLNSVFRCCRLVIPIMEKQGSGSIVNNASITAMRYIGKPQIGYATAKAAVIQYTKASGCMYASKGIRFNCVVPGLMYTPLVENLAESDKSEDQEVARKITQHNVPMGRMGDGFDVANAVVFLASECARYVTSHALVVDGGITESTGTGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PTS8</accession>
    <name>N1PTS8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_34247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446538">
        <property type="protein sequence ID" value="EME45814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PTS8"/>
    <dbReference type="HOGENOM" id="CLU_1008400_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME45814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="276" mass="31000" checksum="9C968C2B0199CD2A" modified="2013-06-26" version="1">MPRDDSVSRGTEATTTERETWKRHVQFVVEKFHDDRERPCHLGEQPPSRTTGHSVNAAPALPFVMARQRPSDRADLFQEVRGSELRIARGKVVLSDIGMQYPSAPGTCEKTLWLQLEDDQNIPGARQIFAIIEVLKNCEVLPPARRVPLAESSGSVTQAAMSWKENRSAEFGRTGEAYVYSTNKQVWHATPYTQHILAGENYTVFQSYHSLPVGATVPTLRAGTYALDSKRVAWGISEWWRTKASRGSSITHAGPISRKWESEGKQRKYAARNFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>N1PU49</accession>
    <name>N1PU49_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2231 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_169770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PU49"/>
    <dbReference type="eggNOG" id="ENOG502S8SF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102285_0_0_1"/>
    <dbReference type="OMA" id="NWWTRRS"/>
    <dbReference type="OrthoDB" id="2580011at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019251">
        <property type="entry name" value="DUF2231_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09990">
        <property type="entry name" value="DUF2231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2231" evidence="2">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="183" mass="19282" checksum="53FEC1D905E8FCF0" modified="2013-06-26" version="1">MAKPVHPATVHFPIAFLMLANGLDVLHALSSYLPTLITSTLPSALDSAKASYYLLSLALITSIPAVLTGGVEAMKMIQKSGMYEKDGTLRNKVKATIAHAVVNDVVIAANTYIWYQRREAVGKSLQGRVTGAYEPETWMIVGEAVMTGLMLVGANIGGNLTYVFGVGLGGGNSLAPKATSKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUU6</accession>
    <name>N1PUU6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deacetylase complex subunit Sds3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_70198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUU6"/>
    <dbReference type="STRING" id="675120.N1PUU6"/>
    <dbReference type="eggNOG" id="ENOG502S0G7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031130_0_0_1"/>
    <dbReference type="OMA" id="NQHQHYR"/>
    <dbReference type="OrthoDB" id="70376at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="580"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME46115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="65476" checksum="746BFD52CB9530AF" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PUX8</accession>
    <name>N1PUX8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_59757</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PUX8"/>
    <dbReference type="STRING" id="675120.N1PUX8"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="OMA" id="MRGHDFV"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF281">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="33"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="96"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME47291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31358" checksum="C9168232442485E0" modified="2013-06-26" version="1">MGTRADILLIASSIQAVDHERRQHKVGKFANLRPFTVDTVAHFPPSLKIICCSGHVYDAADTVALAERGIWYCNTPNACTEAVANAATYLNLNRELGLEATDSQGKALGIVGLGDIGTSIARKCEAVYGMEIHYCGPRRKRGNEELHSHGARYHPSVEAMIPAIDCIILAAPYTSETHHMLSKYQFRLAKPSGLRIVNIARGSRIDEEALLEALESKQVVGVGLDVHEHEPVVNEKLRSNHKVTLLPHIGVCSLTSWINFETQCWDNLAAFFETGTLLTPVHTLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWS8</accession>
    <name>N1PWS8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:ubiquinone oxidoreductase 20.1kD subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_126442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWS8"/>
    <dbReference type="STRING" id="675120.N1PWS8"/>
    <dbReference type="eggNOG" id="ENOG502S52G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100674_0_1_1"/>
    <dbReference type="OMA" id="VYRYYPD"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME46654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21137" checksum="8AD63A0918F7D8EF" modified="2013-06-26" version="1">MASLRSALRVAPRTHFVRPATIPRFAPRSYATVAPNPATDSKSPAQAEQAQEDVTLLGGQGQDPNMNGNYPDPSLTSALPIKRQFRDPYADWWDKQERRNYGEPVHEDNDILGIFTPEEYTHFKPAWGGVLLGTFVATVGVLCAVVYRYYPDRPSVTRTFPDGLETELGGPLARPARKDNDSPAPLDRSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PWV8</accession>
    <name>N1PWV8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_70747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PWV8"/>
    <dbReference type="HOGENOM" id="CLU_2386117_0_0_1"/>
    <dbReference type="OMA" id="DWFHENL"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="94" mass="10558" checksum="1676473D39611AE7" modified="2013-06-26" version="1">MDDLAVAEARTAAIVALWRAWSQHRDLATSVALAYLRRAQQGPPGNEHERLLVDWDNGNLEQHERARLDQLLRELAAAMTGRSIGQMGAWQPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PX09</accession>
    <name>N1PX09_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_52150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446537">
        <property type="protein sequence ID" value="EME46749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="675120.N1PX09"/>
    <dbReference type="eggNOG" id="KOG1795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000380_3_0_1"/>
    <dbReference type="OMA" id="ANKWNTS"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000386">
        <property type="term" value="F:second spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000389">
        <property type="term" value="P:mRNA 3'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="2130"/>
            <end position="2261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME46749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="2362" mass="273376" checksum="BA771C701BD69446" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXA9</accession>
    <name>N1PXA9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_41978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXA9"/>
    <dbReference type="STRING" id="675120.N1PXA9"/>
    <dbReference type="eggNOG" id="ENOG502S4CD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_289380_0_0_1"/>
    <dbReference type="OMA" id="WPQATKH"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1003" mass="107421" checksum="6987336056186B33" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXC0</accession>
    <name>N1PXC0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_166806</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXC0"/>
    <dbReference type="STRING" id="675120.N1PXC0"/>
    <dbReference type="eggNOG" id="KOG2665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_1_0_1"/>
    <dbReference type="OMA" id="GVHFTRM"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="10">
        <location>
            <begin position="30"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME47608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="429" mass="46965" checksum="8F5D805500F44FF3" modified="2013-06-26" version="1">MFSRHALTTLSRHSRCFSSTSKRDADFTHAVIGAGAVGLSIARRLQQVEGASVVLIEKHDMVGSETSSRNSEVIHAGLYYGKDSLKTRLCIEGKAMMYDYCSKNHVGFTNCGKWIVAQDDLQMNECQKVYDFAKEIDVPIRYVPKQEAERREPDVRAEAGILESTTTGIVDSHGYMQALQADYENFGGTTALVSPVTRIEAPAAGNRDWKIWTGSNASEPTASSPTPQTPEQSPNSEHDTFITAETVINSAGLYACAINNMILPPDRHRTPYYAKGTYFTYSKSTPRTSTLIYPAPIPGLGGLGTHLTFDLGGQVRFGPDVEWVDHPHDLAPTPDKKRFEAALEAIKSYLPTVDTSAISLGYAGIRPKLGRMSAVAGGSSFQDFYIKNEEGYHGFVNLLGIESPGLTSSLAIGEEVYRMLYKPAPLDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXK6</accession>
    <name>N1PXK6_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_21480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXK6"/>
    <dbReference type="HOGENOM" id="CLU_2049645_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME47723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="120" mass="14190" checksum="82AB6D77F1E4F63A" modified="2013-06-26" version="1">MSHHVRNARTVVDAPIFIIIVIFIFIFIFIIIIIFFFFFIIFFIIFMFRFIFFIFIFIIITIMARTDVPLVVTARSIDARRSRPTALHRSSIILNHRHPRWSPGRDIHGAHHATSLHGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXM4</accession>
    <name>N1PXM4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_69082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME46974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXM4"/>
    <dbReference type="eggNOG" id="ENOG502RHEE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2263657_0_0_1"/>
    <dbReference type="OrthoDB" id="5332384at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME46974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="103" mass="11413" checksum="B29B072DF2112412" modified="2013-06-26" version="1">MYTDTTLTTATMTILTSADLIQGAVVEKRYTVVDDVQRTYGFPDNNAPSADIAYDCGRGYKAGDKGTYDDPRAMATAPSEVNKCEIIWDFYTEKYLISEDICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PXS1</accession>
    <name>N1PXS1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PXS1"/>
    <dbReference type="STRING" id="675120.N1PXS1"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_420341_0_0_1"/>
    <dbReference type="OMA" id="CPPTTYG"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109674" evidence="2">
        <location>
            <begin position="17"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="652" mass="64420" checksum="5FD1A1C41DF655BC" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYG4</accession>
    <name>N1PYG4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_69389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYG4"/>
    <dbReference type="eggNOG" id="ENOG502S55X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062870_0_0_1"/>
    <dbReference type="OMA" id="EVRVCWL"/>
    <dbReference type="OrthoDB" id="3360032at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019433">
        <property type="entry name" value="GPI_ManTrfase_II_coact_Pga1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022:SF1">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10333">
        <property type="entry name" value="Pga1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004110322" evidence="2">
        <location>
            <begin position="21"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME47445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="226" mass="24842" checksum="4903169FC6669281" modified="2013-06-26" version="1">MRGLSCAFSLFAFVVTAALANTEKTIFIAPSAIILPHSGASLNALQLDTLTPADSALRTAIPVLFPSADHPKGHESWYLLRGLKAGQRHEIRICWAAIQPTEFWLDVYNITHVFDTPNLIQSLAAFAEEQASSSQAVAKFDPSAETILLLHVRAAADYFTTNRSLMLQPEPVDVDIILDPYLLNVFPASLLSTAIYLVVLAVGGWYLSGKIWRLLQPNSESKIHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PYX0</accession>
    <name>N1PYX0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DOTSEDRAFT_69949</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PYX0"/>
    <dbReference type="STRING" id="675120.N1PYX0"/>
    <dbReference type="eggNOG" id="KOG1149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_1"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="13">
        <location>
            <begin position="77"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EME48178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="686" mass="76920" checksum="9B28081E254FAC21" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q065</accession>
    <name>N1Q065_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_67944</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q065"/>
    <dbReference type="STRING" id="675120.N1Q065"/>
    <dbReference type="eggNOG" id="KOG1692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_4_0_1"/>
    <dbReference type="OMA" id="MQVRDRN"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109474" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME49067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="211" mass="24256" checksum="0F5C08BACDC4AA3E" modified="2013-06-26" version="1">MAFLGLFLSLLSFFAISHAHNIQLRAHSRECFHEELHRDDKMTVTFQVGDREFGGSGNLDIDFWIKAPSGNNIIDQRTVSSGDHSFDAREDGRYAYCFSNEHWSANTKEVSFNVHGIVYVPESDTPSDPLEKEIRIMSDHIAQVRDEQSYMVLRERTHRNTAESTNARVKWWSIFQLGVLIGEGVFQVWWLKRFFEVKSPGQPSFNRGALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0J8</accession>
    <name>N1Q0J8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_78124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME47999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0J8"/>
    <dbReference type="STRING" id="675120.N1Q0J8"/>
    <dbReference type="eggNOG" id="KOG3315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073154_2_1_1"/>
    <dbReference type="OMA" id="YMVKFDD"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000002">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME47999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="230" mass="25762" checksum="3B236C1FA18B7748" modified="2013-06-26" version="1">MPGMSNPPPPTAPPKELTYTPIHVAKPFQSTLRYPSSRKTIYDRNLNRTKATETSLASFSYLFNTLITYHHSKSGSVSEIETRLNRAGYPIGIKLLDLLLYRQSPRNAQRPTRILDLLQFIHGTLWRALFNRPADALEQSNSKKNEYMIVDNEPVVNTYISIPKEMSQLNCAAFVAGIIEGICDAAAFSTEGVSAHWSEGDEMWPGKTIFLLRFKESVVEREDAIKAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q0M4</accession>
    <name>N1Q0M4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_42302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q0M4"/>
    <dbReference type="STRING" id="675120.N1Q0M4"/>
    <dbReference type="eggNOG" id="KOG1684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_22_0_1"/>
    <dbReference type="OMA" id="EVFTMEY"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="8">
        <location>
            <begin position="46"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME48019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="487" mass="54491" checksum="3E5866A56DA06863" modified="2013-06-26" version="1">MPLRAKILSPALQQSAARSISSDSQIKELPGDEPNDVLFGNQGGVRNITLNRPKKLNSLNGSMARKIVPRLQEWSQSDLANVIVIKGEGRAFCAGGDVAWLAQRNKEGTEGQQESKDYFALEYKLDHLISTYRKPYVAFIDGITMGGGVGLSLHAPFRIATENTVFAMPETTIGFFPDVGASFFLPRMDGELGTYCALTSEQIKGVNVFYAGIATHYIHSSSLPDLEARLAELDFKDYDDLQHRNRIINQTVEEFVTGLPHDQPIGAPVGGNIRAAIDYAFQPAYDDIDQILKALQGLEEMVPTKPAHPEIIEWAAKTRKTILQRSPTSVKVTLRQLREGSQWSMAETFRKEHAIASRFMEHPDFIEGVTALLVDKPKRTPHWTPATLREVSEEDVASFFNHRTDFELLTKESGSSGEDYKAYPHAWIGLPSENSVRTQVGQEKSREQIVEHFVNQTNGKQGVKEKVEEILTRKAPQQENGMLQWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q124</accession>
    <name>N1Q124_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_95910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446536">
        <property type="protein sequence ID" value="EME48154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q124"/>
    <dbReference type="STRING" id="675120.N1Q124"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_2_3_1"/>
    <dbReference type="OMA" id="FRDPTIC"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="232" mass="25993" checksum="F6AA176D310748D2" modified="2013-06-26" version="1" fragment="single">MTSKLRILCLHGFTSNGHVHAHQVRRITKALPQYEFLFPDGPHVVDVASQMDMDTPANQAWADMVNMLSTSGHRAWWFARDGDWNNKETGGFYGLEKSLDYIGSYIQDSGPVHAIWGFSQGACFAGMLCALMQEKHSSHPLRKHLPAKISPPMAGVIFSGFRARFPQYDGLYEPGIDMPMLHVIGKQDALVHSERSEAFIRVCKNSDVLIHAGGHDIPKSVEDQARIFEFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q128</accession>
    <name>N1Q128_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_18891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q128"/>
    <dbReference type="STRING" id="675120.N1Q128"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_11_1"/>
    <dbReference type="OMA" id="KGKWFKT"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="473"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME48345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="64996" checksum="EE4E158E9CE0823C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q244</accession>
    <name>N1Q244_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_68583</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q244"/>
    <dbReference type="STRING" id="675120.N1Q244"/>
    <dbReference type="eggNOG" id="KOG3731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_9_1_1"/>
    <dbReference type="OMA" id="RAYFGAC"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16032">
        <property type="entry name" value="choline-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000032">
        <property type="entry name" value="Choline sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017785">
        <property type="entry name" value="Choline-sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025863">
        <property type="entry name" value="Choline_sulf_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03417">
        <property type="entry name" value="chol_sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12411">
        <property type="entry name" value="Choline_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Choline sulfatase enzyme C-terminal" evidence="5">
        <location>
            <begin position="440"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME49831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="60065" checksum="769C12ED096ADE23" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2K7</accession>
    <name>N1Q2K7_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_67823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2K7"/>
    <dbReference type="HOGENOM" id="CLU_2867618_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME48885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="64" mass="7054" checksum="7C3D7F51996AD142" modified="2013-06-26" version="1">MLKAHGVRARTWTRLRVVRMKSSGYAVPLPITQFLTYECLAILIRGAAAVPEELVITGIETVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2Q6</accession>
    <name>N1Q2Q6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">H-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_67705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME48754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2Q6"/>
    <dbReference type="STRING" id="675120.N1Q2Q6"/>
    <dbReference type="eggNOG" id="ENOG502RP86">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058882_0_0_1"/>
    <dbReference type="OMA" id="QIAIETW"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098636">
        <property type="term" value="C:protein complex involved in cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046871">
        <property type="term" value="F:N-acetylgalactosamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2080">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052487">
        <property type="entry name" value="Galactose-binding_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037221">
        <property type="entry name" value="H-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019019">
        <property type="entry name" value="H-type_lectin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46938">
        <property type="entry name" value="DISCOIDIN-1 SUBUNIT A-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09458">
        <property type="entry name" value="H_lectin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141086">
        <property type="entry name" value="Agglutinin HPA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H-type lectin" evidence="1">
        <location>
            <begin position="58"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="H-type lectin" evidence="1">
        <location>
            <begin position="166"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="H-type lectin" evidence="1">
        <location>
            <begin position="261"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME48754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="339" mass="37294" checksum="395C6932CE9EEE1C" modified="2013-06-26" version="1">MPAPKLHAHAHAHAHAVPRFAHLSEPGPDDGFFSTSEVRSKSEPALSTSRLIALPRGRYKEPPNLAAGFRSLDISCERSIRANIVANDFSTEGFQIAIETWGSSQLYEASVAWIEHKADAKDCVFGQFDTSTATPWPSADPFASLSPGKSNSQSGRDLQQKHAKAFLFPTPFSEPPEVVCWLNRLDLSSGRDYDYKIRAFADEINTESFLAHLSTWHSGRMPGAALCWIAFPKSKRSAESGCISTNHVRKRTDPRPITTAVVKFKKTFERPPTVIAAINMIDAAGNADLRIKLAISKVTKEGFRWTFETWDDSTLYAASAHWIALGATVPARPKSTGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q2Y8</accession>
    <name>N1Q2Y8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q2Y8"/>
    <dbReference type="eggNOG" id="ENOG502T0X6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_731560_0_0_1"/>
    <dbReference type="OMA" id="WEGSMAG"/>
    <dbReference type="OrthoDB" id="4167490at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="332" mass="36307" checksum="A23B05662C4AD8B5" modified="2013-06-26" version="1">MLPSHSSDFTPVKIRGKRNAIPAEKWHDAKRRKPQLQRRRLSNATMPTSSSVSRKRLQTDIGGSPLEMLPAEVTHHIFGYSANVNLPLASRQLAAKLSKSTHLEHQLTETLLAPVLRLLGNEEAGAAQLSAATRLLNSRFVTFEFFKSWLRGHNEARSLHVSDGAQDEAYWRAIWTALQPSPTLLPPSKLISPPFTAAKTSFLAVLVQGTPGVSTIDPAYGEFALQGLQSAIPARQGKVVSLLLAMGVTVSTEMLRIAVIDSGCDKDIVTRLLDATAPADGSLPYQQGVDLLDPSLWAWAEKARKDGDDKGQWLVALLRDRQQRKATAESIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q316</accession>
    <name>N1Q316_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_68870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q316"/>
    <dbReference type="STRING" id="675120.N1Q316"/>
    <dbReference type="eggNOG" id="ENOG502QQUZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009044_0_0_1"/>
    <dbReference type="OMA" id="GRHFWAQ"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="1"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME50151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="722" mass="80136" checksum="E6B7CFFE08936ABA" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q3X7</accession>
    <name>N1Q3X7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_142863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q3X7"/>
    <dbReference type="STRING" id="675120.N1Q3X7"/>
    <dbReference type="eggNOG" id="KOG1613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_5_0_1"/>
    <dbReference type="OMA" id="EIKAFWV"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="47"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME49154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="338" mass="36438" checksum="1109217A66FD27FA" modified="2013-06-26" version="1">MSNASESAAALTFARETFAKLTPGPFLLAHLKQEPRPVRPNGRQLFESRQPAVNTGSLTHSNGSAVVRVGDTAIVCGVRGEILLASDIPHAPHEDPEEQDLIEELGLLVPNVELSTGCSPAHLPGNPPSTLAQSLSYRVCSLLQDSRCIDASSLRIEYTEPDTGDDDAADESRVVIKAFWTLYIDVLCLALDGNAFDAAWLAITAALRDTTLPKAWWDQDREGVLCSPLLSDASALTLNEIPSVSTFAVFTTASPLQRPENAQSWVLVDPDAFEEDLCDEMLTIAVRKTGSGGTTLLKVEKSGGSFIGTLAIRDCVEAASRRLADTELALKNSRWRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4T3</accession>
    <name>N1Q4T3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_121901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4T3"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513077_0_0_1"/>
    <dbReference type="OMA" id="WETCFDA"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME49875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="56817" checksum="AD0A43F66BE9DEC1" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4T4</accession>
    <name>N1Q4T4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME49699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4T4"/>
    <dbReference type="eggNOG" id="ENOG502RHNW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121514_3_0_1"/>
    <dbReference type="OMA" id="DHDAHMK"/>
    <dbReference type="OrthoDB" id="529205at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME49699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="106" mass="12237" checksum="40C39F9CD71DD317" modified="2013-06-26" version="1">MAFLRPISRVTTRRPVHLTRFQAPARTLTYTPCMRLKEDKIQTPEEIESAKQEQLKTGKRREELESASESVVGADREEVSNHDNHIKELQQEGAKEKQKEHPEGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q4Z6</accession>
    <name>N1Q4Z6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_68774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q4Z6"/>
    <dbReference type="STRING" id="675120.N1Q4Z6"/>
    <dbReference type="eggNOG" id="KOG3912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025028_3_1_1"/>
    <dbReference type="OMA" id="FIYKHNV"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004109573" description="Integral membrane protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME50025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="48958" checksum="6304C735C2300259" modified="2013-06-26" version="1">MTSQAMIPVLVAFMLLTGVCNTLLTKYQDLQCVADCDTDRPKKFEQPVIQTLQMFVGEAGCWLVVFLSWLVQRVLERDVVPIQDIRYVPVASQDTGEEDEDDENELHHDLSSSQTLVDPTNIIAAPKLVAELLHKERQPLDGWNVTLLALPAICDICGTTLMNVGLLFVAASIYQMTRGALVLFVGLFSVIFLKRQLGAWKWASLFIVVLGVAVVGLAGVLDQKHGAPTLPKDAQSGDTIDVLAHAGLALRRGVSALEEHTAAETVLGFFLIAAAQIFTATQFVLEESIMERYSMDPIRVVGWEGIFGFLVTLIGMGVLHAAIGQTDAGRGGYFDAREGFYEMFHFRSIGVTSILIMISIGGFNFFGLSVTRLISATARSTIDTCRTLFIWLVSLGLGWESFKWLQVVGFVLLIYGTAVFNEVVRPPTVAWLKRQKRVALQQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5C4</accession>
    <name>N1Q5C4_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_68882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5C4"/>
    <dbReference type="HOGENOM" id="CLU_2073074_0_0_1"/>
    <dbReference type="OMA" id="NQYEDYD"/>
    <dbReference type="OrthoDB" id="10569291at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME50164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="118" mass="13080" checksum="40BAC3BD925A2C11" modified="2013-06-26" version="1">MTSLLKKLSIRKSSKPSSPATSPHGIPEATNQYEDYDERYEQQFRQSVQKQENASQRPSLLTVGPGCGTPGNAGRHPSQYGLGDIPVPEEKLERELELDERISGERKNSTGGEGARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>N1Q5E0</accession>
    <name>N1Q5E0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_41336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446535">
        <property type="protein sequence ID" value="EME50204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1Q5E0"/>
    <dbReference type="STRING" id="675120.N1Q5E0"/>
    <dbReference type="eggNOG" id="ENOG502SNG2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_436261_0_0_1"/>
    <dbReference type="OMA" id="QWANQRE"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="424"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME50204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="580" mass="63534" checksum="1C5051C327D84F27" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2WJJ9</accession>
    <name>M2WJJ9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_75032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WJJ9"/>
    <dbReference type="STRING" id="675120.M2WJJ9"/>
    <dbReference type="eggNOG" id="ENOG502SJRS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015365_0_0_1"/>
    <dbReference type="OMA" id="WSHHISR"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME39143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="708" mass="79096" checksum="B64304552BC1EDCE" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2WLP9</accession>
    <name>M2WLP9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_72397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WLP9"/>
    <dbReference type="STRING" id="675120.M2WLP9"/>
    <dbReference type="eggNOG" id="KOG0291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010458_1_0_1"/>
    <dbReference type="OMA" id="HKINGIC"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000470">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="462"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME42958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="604" mass="66074" checksum="8AFAC3BE1B139ABF" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>M2WN72</accession>
    <name>M2WN72_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_35718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WN72"/>
    <dbReference type="HOGENOM" id="CLU_1970525_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME43463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="127" mass="13395" checksum="6BD6B48A61A5EF48" modified="2013-05-01" version="1">MSLTINQKPNSTANNGCLASEQVFLVGVLAVAALGHVEDVCGVWKPRVPASTNSREDTLVATSGQSVCWLALEVTGIQFRCEDSVASKGSGDCIKSTDILQSPAKLRIYGISLASVQDRPEPCFAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2WNB9</accession>
    <name>M2WNB9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_89346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2WNB9"/>
    <dbReference type="STRING" id="675120.M2WNB9"/>
    <dbReference type="eggNOG" id="KOG2311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_1"/>
    <dbReference type="OMA" id="CNPAMGG"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000145">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="7">
        <location>
            <begin position="584"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME43513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="687" mass="74990" checksum="9F2D696C95200A04" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2XG69</accession>
    <name>M2XG69_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_39608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446548">
        <property type="protein sequence ID" value="EME38066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XG69"/>
    <dbReference type="HOGENOM" id="CLU_1713203_0_0_1"/>
    <dbReference type="OMA" id="AEVCPHK"/>
    <dbReference type="OrthoDB" id="10480078at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME38066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="181" mass="21108" checksum="E1EC028C1980D47C" modified="2013-05-01" version="1">MVPASSKKNTRAGSTTRPAKARVTNERWLYRDYMVVRVLVHEYHDNHQDFRKHHLSLIFAEVCPHKMQYPSNRLYEHRSVFKNTSVAKDKQRAWRRNEFANIESPGPDEDLVVEIKDAINATTAFKVIQDANEDSYMEECGRLEGEDAAWERGDSRRDESEQEKNKSDESDGDNGENYRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2XJ63</accession>
    <name>M2XJ63_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_47986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XJ63"/>
    <dbReference type="STRING" id="675120.M2XJ63"/>
    <dbReference type="eggNOG" id="KOG3060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052388_0_0_1"/>
    <dbReference type="OMA" id="LMEMLFY"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001208">
        <property type="entry name" value="Tetratricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="106"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME39497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="331" mass="36938" checksum="19B5F33B790AF5D7" modified="2013-05-01" version="1">MSTSLLLTPSTDVSPESTLALSQQAPSYYKSQSGWSLPYPLSLFLNNESQEKWQSYENIFLSTLRTGDTASAYLYLEELTDRFGPTNERVAALRGLYAEATAKTPEELENVMRHYEEILKEDPTAFTIRKRRCALLRSMGKTADAIQALTNLLDASPTDAEAWAELGDLYVEQGLWEQAVFCLEEVLLVMPNAWNVHAKLGEILFLQARARDAGAEQLKILSDSMRRFCRSVELCDDYLRGYYGLKLTTTRLLETLSSTKKSQMVATDAVTGELAPPTIEAVTKLNEVATEKLAEIVRKGTAGAKGWDGYNVAELAAARELLDRDSQKIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKK0</accession>
    <name>M2XKK0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_72425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKK0"/>
    <dbReference type="STRING" id="675120.M2XKK0"/>
    <dbReference type="eggNOG" id="ENOG502S6PS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_1_0_1"/>
    <dbReference type="OMA" id="ERMDITY"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37930" checksum="C55338722EF78678" modified="2013-05-01" version="1">MDMQLDQVEVEARDSGDAFSDDSGYDEGYLSTESVASSIFEYEQENGRTYHAFRRGKYVMPNDESEQERMDITYHSIRLTLEEQHFVAPIQKPRMILDIGTGTGIWAIDVADDFPHAQVIGTDLSPIQPTAVPPNLEFQIADADETWTFNQQFDFVHSRLINGFSVKSWEFFYEQAFKVLQPGGWVENQEFDLNFGSDDNTFPEDSAVQRWENLWEAGIQKFGLTGRCYPEQMKLAMEKAGFINVAIKPYKIPIGPWPKNKRLREAGLLFLVGLLEGVSGLSLRTFTQGLGWTVEELEVLLMEVKHEWKQKRIHTYCPLYVVHGQKPPSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2XKX8</accession>
    <name>M2XKX8_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS1</name>
        <name evidence="8" type="ORF">DOTSEDRAFT_72517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XKX8"/>
    <dbReference type="STRING" id="675120.M2XKX8"/>
    <dbReference type="eggNOG" id="KOG1628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062507_0_0_1"/>
    <dbReference type="OMA" id="TRFKGHE"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EME43162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="257" mass="29235" checksum="506C9445278BEE8D" modified="2013-05-01" version="1">MAVGKNKRLSKGKKGLKKRTDPFARKDWFSVKAPSTFAIRDVGKTLVNRTTGLKNANDALKGRIFEVSLADLQKDEDHAFRKVKLRVDEVQGKNCLTNFHGLDFTSDKLRSLVRKWQTLIEANVVVKTTDDYLLRLFCIAFTKRRPNQIKKTTYARSSQIRAIRKKMTDIMSREAQSCTLSQLTTKLIPEVIGREIEKSTQGIYPLQNVHVRKVKLLKAPKFDLGNLLSLHGESSTDDSGQKVEGNREFKETVLENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>M2XLD0</accession>
    <name>M2XLD0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_45238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XLD0"/>
    <dbReference type="HOGENOM" id="CLU_2922612_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME43262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="61" mass="6620" checksum="9F02A2F5BDDA0390" modified="2013-05-01" version="1">MQAQAAERSAIIKDARASEFREQRKVKGKDMSKKSPAAASPYAAAARVHTNPRPQDQSAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2XLY7</accession>
    <name>M2XLY7_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_54265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2XLY7"/>
    <dbReference type="STRING" id="675120.M2XLY7"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="OMA" id="TGWIMYM"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF4">
        <property type="entry name" value="ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="129"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME43452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="703" mass="79083" checksum="0DBC64A6F8F3D5BC" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y2M4</accession>
    <name>M2Y2M4_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_83246</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y2M4"/>
    <dbReference type="STRING" id="675120.M2Y2M4"/>
    <dbReference type="eggNOG" id="KOG1304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009646_3_1_1"/>
    <dbReference type="OMA" id="DTHRHIY"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990818">
        <property type="term" value="P:L-arginine transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089708">
        <property type="term" value="P:L-histidine transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089707">
        <property type="term" value="P:L-lysine transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000067">
        <property type="entry name" value="Transmembrane domain transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="641"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="746"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="381"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME39544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="785" mass="86497" checksum="363BE137415BF826" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>M2Y3F0</accession>
    <name>M2Y3F0_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_24864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2Y3F0"/>
    <dbReference type="HOGENOM" id="CLU_594505_0_0_1"/>
    <dbReference type="OrthoDB" id="3649524at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="460" mass="46019" checksum="C3A70615B27F9FE6" modified="2013-05-01" version="1">MGPTISGQPNTIVTLDTTFTSPTVYIAISGSYIYQSNSQNISDFKILIFPQTAASVSSLRGMIGGGFESQAYPFNYADLNSPVPAAAYRGQPKCFTYADYFGTITTVYRASDGSIDTTTSVGLANVALLNLCSTTYKDYNPASSIPPELTSLFIAEANAAKAPAKGNSQSDPDTSPTNGAITTGPDDQQVTAVNDPSNGGVVVSGTTIAHEQSANGAGIGSVAAQTGGSVVNVQSQWFSALAAPTPSAANGAVGRGGNGQAATVLHQGGGSVIIGSVIPPVGATSSIAGIGNVVAQSDGVVVNGASTIPFSAVQGGASYAPADPASDVISIGNQRITAAPNGGFVVALDQTLTPGEQVTVSGTMYPLESGGSAIVVNGGTGSVQHGGTSTSPSAATTTTTAPERGGSSMPSSGNGDVARQTFWAVLQRGSSTSLGMVLAPLPGLAMTSSGNRERQHMFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>M2YJ86</accession>
    <name>M2YJ86_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_92243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB446546">
        <property type="protein sequence ID" value="EME38981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YJ86"/>
    <dbReference type="STRING" id="675120.M2YJ86"/>
    <dbReference type="eggNOG" id="ENOG502S4E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110291_1_1_1"/>
    <dbReference type="OMA" id="KVGMARK"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME38981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20661" checksum="C010504A91800E5E" modified="2013-05-01" version="1">MQARVLPQVAQHHSRYSTELRNHHLPQPPHHPNYQPTPTAKMPITLTLPTTYGYTAILALGAIPLLSFFQGMTVSSLRKAARVPYPNAYASAEQSKSSPEAYKFNCAQRAHGNLLENMPQTIAMLLFAGLFYPTATPVLGATWVVGRVLYAYGYITSKENGKGRSLGAVFWLGQLGLMGLCVSAGLKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKK1</accession>
    <name>M2YKK1_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_75237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKK1"/>
    <dbReference type="STRING" id="675120.M2YKK1"/>
    <dbReference type="eggNOG" id="ENOG502S3PM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061001_1_0_1"/>
    <dbReference type="OMA" id="IRCHADW"/>
    <dbReference type="OrthoDB" id="5357075at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME39501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="339" mass="38319" checksum="65917069A208398F" modified="2013-05-01" version="1">MLSRPVLVHYCDSCNYNTPVKHTGSVREQDHICTHCGVKQRGADVVGESKGAMNSMQQDDLAQLFAQSMQLQQPATIQQQPVFVELVQPMSGKTVEAPIHYASAHYTPNSAHMRAETQSEPAQSPPPPYREALMPDAMADVLRQNSIDPLALLPNQVDLFLNADYEQRLRLLELWRISPPSYPHEQQAQQQWMNTSVEKEEHAARDRYEQQMQQRSACQEKHMFDTFVPKPESQAPVRLRSASSSAGTVTIKPMEAEPYIINGYEIAAASPRAVEPVYAAAGMWSAPRYEATLQQARLEDQYGMIDQIRCHADWERMNQQQFHGMHGPVEGVDSMDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>M2YKU1</accession>
    <name>M2YKU1_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DOTSEDRAFT_75229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446545">
        <property type="protein sequence ID" value="EME39485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YKU1"/>
    <dbReference type="STRING" id="675120.M2YKU1"/>
    <dbReference type="eggNOG" id="ENOG502SC62">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098671_1_0_1"/>
    <dbReference type="OMA" id="GVWRTTH"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877:SF2">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EME39485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="205" mass="23713" checksum="435EE8A617FA1F21" modified="2013-05-01" version="1">MRRKSSTKQDWIIRQVTEENIEQVVGFINDTRHQMFAGLVWKGAPLADSTHRLVRTGWFVAAYERPALLQEGGSQDLRLVGTVGIVPYNHRFPQLKLSNLRTVEVVRLFVVPDCRRCGLGTLMVDSLCKEARSSDIDCLYLHTHPFLQGASEFWSKMGFRTVDVDREDAVWQTTHMIKIPKMSKSWSWLWTKARGSFREFRRASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M2YLV5</accession>
    <name>M2YLV5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DOTSEDRAFT_173558</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME42996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YLV5"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OMA" id="AYYFGGM"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF44">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="18"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EME42996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="547" mass="59175" checksum="3F577D0532BF1965" modified="2013-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>M2YN04</accession>
    <name>M2YN04_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DOTSEDRAFT_72665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YN04"/>
    <dbReference type="STRING" id="675120.M2YN04"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_6_0_1"/>
    <dbReference type="OMA" id="EPYIAVC"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF2">
        <property type="entry name" value="HYPOTHETICAL GLUTATHIONE S-TRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="86"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EME43325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23733" checksum="4F8E61A6D62DC294" modified="2013-05-01" version="1">MEDLTLHQYHNSGNCYKIRLAAALLNIEITLEDYDLVKGESRTPEFLSKVSSNGSVPVLQIGNTFLPESGAALNYIAAGSHLVPKDRLQYAEMLRWMFFEQYQIEPTVGSLRFWTRKLGLENLDEAKKGQVNAKRQAGSAALDVMEQHLSGRRFFVREKFSLADVALFGYTHVSEQGDFDLSKWPNVKAWCERVKEQPGYVPIGNENWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-05-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>M2YPB6</accession>
    <name>M2YPB6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DOTSEDRAFT_89313</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446540">
        <property type="protein sequence ID" value="EME43466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M2YPB6"/>
    <dbReference type="STRING" id="675120.M2YPB6"/>
    <dbReference type="eggNOG" id="KOG3309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_0_1_1"/>
    <dbReference type="OMA" id="TLGWGWR"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="8">
        <location>
            <begin position="72"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EME43466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="187" mass="20539" checksum="7ED4612C02F74531" modified="2013-05-01" version="1">MVQLHCKAVSRSLTKLLRTASRETRTQWVAQSKSSPTARSLLPRTHTASRVFSTTPSRHHGDLTPPKPGEERKVTFIDKEGHEHTFEVSDGDNLLDIAQANDLEMEGACGGSCACSTCHIIVAGDEMYDKMDEPSDDENDMLDLAFGLTETSRLGCQVAMSKALDGLVVKLPSMTRNLQASDFEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PBQ5</accession>
    <name>N1PBQ5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Yos1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DOTSEDRAFT_141124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PBQ5"/>
    <dbReference type="STRING" id="675120.N1PBQ5"/>
    <dbReference type="eggNOG" id="KOG4779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152125_0_0_1"/>
    <dbReference type="OMA" id="VQTVMRM"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EME38361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="9688" checksum="93D54C04F9A5997D" modified="2013-06-26" version="1">MATLLFSFGGLFQVAVLLTNAIAILSEDRFLARIGWGSSSASTEPSFGGGNAGGDTSTKAKLIQLISSVRTLMRIPLIFLNVLIIVWAVAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>N1PC20</accession>
    <name>N1PC20_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAUS augmin-like complex subunit 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_114926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PC20"/>
    <dbReference type="STRING" id="675120.N1PC20"/>
    <dbReference type="eggNOG" id="ENOG502S4RN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013984_0_1_1"/>
    <dbReference type="OMA" id="IEWALYH"/>
    <dbReference type="OrthoDB" id="5575722at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028163">
        <property type="entry name" value="HAUS_6_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14661">
        <property type="entry name" value="HAUS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAUS augmin-like complex subunit 6 N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME38308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="565" mass="63811" checksum="1C74FE7075348BF1" modified="2013-06-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCG5</accession>
    <name>N1PCG5_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_178830</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME39957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCG5"/>
    <dbReference type="STRING" id="675120.N1PCG5"/>
    <dbReference type="eggNOG" id="KOG4513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_1"/>
    <dbReference type="OMA" id="FMDGRDT"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="7"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="92"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME39957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="521" mass="57581" checksum="B6BB8B9C4F38927A" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCK2</accession>
    <name>N1PCK2_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_137794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCK2"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005562_3_0_1"/>
    <dbReference type="OMA" id="PLREWHP"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="58783" checksum="16E09AB2F06C645C" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCM9</accession>
    <name>N1PCM9_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_74797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCM9"/>
    <dbReference type="HOGENOM" id="CLU_1540005_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME40052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="174" mass="19323" checksum="4B69271DC721A801" modified="2013-06-26" version="1">MIAEGGLLISSAIARMSTPALPRCNNRFSYSAAQHSLVQVPQYVAMECQCFTSAVCHDIFDGGHPINFAIVPLLHPAIATLRASRELLIQMIPSRFTIYTEVLRAQAVAICRGPSGAFAGLTRRDRISSHGVPRLVRLTIMIENRSRVEIVDPENLHRLRLELPTMVYKSQHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCN6</accession>
    <name>N1PCN6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DOTSEDRAFT_158719</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCN6"/>
    <dbReference type="STRING" id="675120.N1PCN6"/>
    <dbReference type="eggNOG" id="KOG0761">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_0_0_1"/>
    <dbReference type="OMA" id="YWWGYES"/>
    <dbReference type="OrthoDB" id="1747031at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031921">
        <property type="term" value="P:pyridoxal phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="45"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="198"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="306"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EME40062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="45838" checksum="44130FA8C538076C" modified="2013-06-26" version="1">MAAVHTQGQDHDRILSADGEGISDTNTLHLTMPPNTARTAKDDETSAGQKMLSAVTGSILTSLLVTPLDVVRVRLQSSSSPSPSARLPAFVQLPPNLGVTACCREVFWVQNQSQFCVASPAVIDERVISDCAAEETQRKTFNSTLDGIRKIARNEGIWTLWRGLSPTLLMSIPANVIYFAGYDWLRHSKRSPMKDHVSDDYAPLVAGSVARVLAAIAVSPIEMLRTRMQATHSNEKNVMRATVTGLQEMVSSQGYTSLWRGLSLTLWRDVPFSALYWWGYEWGRKRLDHNRVQSTIFSGKDGSHYQLLLDSFIAGAGAGGVAALVTTPFDVGKTRQQTVINSTMSAEKRRNSPEGRTMPRLLWHIYKTQGTSGLFKGWAARCLKVAPACAIMISSYEIGKKMAVTVNDKKYEGRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>N1PCQ9</accession>
    <name>N1PCQ9_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_179024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PCQ9"/>
    <dbReference type="STRING" id="675120.N1PCQ9"/>
    <dbReference type="eggNOG" id="ENOG502RG41">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_647619_0_0_1"/>
    <dbReference type="OMA" id="FYWADKF"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="11"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="263"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="370"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="494" mass="55258" checksum="B13E0BC575145E80" modified="2013-06-26" version="1">MVTPRGKGHEVEFYYDISCPFAYIASTKIDALAQRTNATLIWRPVLLGAIYRATNAPQGAAGSASDVFNPTKKAITSRAFHRTLKRTGIPYNEPPRHPHKTTAALRLLYFAPPSERPALTKALFDSYWVRTENVSDKAVLVDAVHRSGISDASSIISAINGGSFEGAQQRKDLEVSTDLAVKRGSPGVPGFWIPEEVWIDQSNQKRTGRLYWGQDRMHFVEAVLESLNEGRNGDSIARISKPLQALLPKSTRVGIPTGTEVKLEFWYDFSSPWAFLGWTQLARIKRQFGKKLHIEMKPFLLGILFREIGAPNTPMAAISEQKRNYSTLDHSDWVRWWNAINEQDGCPDKNIDFYWADKFPIRTPTVLRAALVEPKLVDVLYRACWERNLDMSSVETLEKVILQAGYNGAGVLTRANCLDVKQDLRARTLEAKESGLCGVPSYRVFRRQAGSLNRWSQVGDIVWGQDEISIVEDMIAGSDGDAIASVEATSKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>N1PD19</accession>
    <name>N1PD19_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_39364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446547">
        <property type="protein sequence ID" value="EME38329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PD19"/>
    <dbReference type="HOGENOM" id="CLU_1294378_0_0_1"/>
    <dbReference type="OMA" id="RSCEDRI"/>
    <dbReference type="OrthoDB" id="3650808at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME38329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="233" mass="26881" checksum="8FC7997606B2D28A" modified="2013-06-26" version="1">MSNHRNIFPFFSLPRELRDLIYPYLVFESGYIPLTNELRFHVYDYPLPHLFRINHQFKSELDETVLEISSLSAHHAGIAGLSLGNAVSELPPPLKGIRMVRFDVQDKWEDNLIGGVKWNDAWIRGILNDMNSTMSKPMQIAIHIHLGYHTTAEDMESAILWSGIWVDRGEVQDLKITRPGRERSCEDRIVLSHWNREARQFVRVAKDLSKGREENVSGPAGLLWQGEVAYLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PDQ5</accession>
    <name>N1PDQ5_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_74166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PDQ5"/>
    <dbReference type="HOGENOM" id="CLU_1266869_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="218" mass="23452" checksum="3784AF65D06FF121" modified="2013-06-26" version="1">MMLQGDTGPLHSEVTMGPSEDNYSGRDTEGLPAFEGEEGSQTAAKGARIEPGQKSVEPKSVVDHSTETAIFRTAAKSNEALDQGTFTRPTDEDISKPEKAQTDLLAGQKRAKKADQSDEAKIFVFKSLSVDRSAAAAHLAKKRIISSANDDTATVEANLQPLCKRIFAALTAFHGPPSSTWGEMYRQEYELGQANAAEVVKGMVADVEGGRQLRLRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE27</accession>
    <name>N1PE27_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DOTSEDRAFT_74430</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE27"/>
    <dbReference type="STRING" id="675120.N1PE27"/>
    <dbReference type="eggNOG" id="KOG1622">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_1"/>
    <dbReference type="OMA" id="IWQSFAV"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="214"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="242"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EME40868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="542" mass="59994" checksum="4A82D5B03A305345" modified="2013-06-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE43</accession>
    <name>N1PE43_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_91559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446544">
        <property type="protein sequence ID" value="EME40379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE43"/>
    <dbReference type="STRING" id="675120.N1PE43"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_0_1"/>
    <dbReference type="OMA" id="RDSAICY"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="275" mass="31562" checksum="75C1D86EDB0DB156" modified="2013-06-26" version="1">MRLLSADAEKPALKTFFNETERPEYAILSHTWMVAEDEVSFSDLADLDRARQKRGWKKIQHTILQAQAHDLDWVWVDTCCIDKSSSAELAEAINSMFRWYRDSAICYVYLDDVPDLTEWLELTHARWFTRGWTLQELLAPNDAHFFSQDWQILGDRGSLATLIAQAHGIGEGAASALHTLRHALTTRVTSFFEGFSIAQRMSWAAGRRLTRVEDEAYSLLGLFDANMPVLYGEGNKAFFRLQQEIMKTRMDHTIFVWEYDAPTGLYGTTDGQHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>N1PE53</accession>
    <name>N1PE53_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DOTSEDRAFT_74451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PE53"/>
    <dbReference type="STRING" id="675120.N1PE53"/>
    <dbReference type="eggNOG" id="KOG0883">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_38_1_1"/>
    <dbReference type="OMA" id="XHSVRGV"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EME40898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="114" mass="12450" checksum="283AB7DBF658F72E" modified="2013-06-26" version="1">MVQGGSPASGSTKESNSVYGEMFEDEIKPSLKHHARGIVSSANKGPDTNGSQFFITLAAAPHLDGKNTVFGRVLEGWDVLDKMEEIKVDKKNRPQETIKIQSAQMHANPLADER</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>N1PFR3</accession>
    <name>N1PFR3_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DOTSEDRAFT_74492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PFR3"/>
    <dbReference type="STRING" id="675120.N1PFR3"/>
    <dbReference type="eggNOG" id="KOG3423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064104_0_1_1"/>
    <dbReference type="OMA" id="PNAMNMD"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EME40954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="27779" checksum="B42FA66F5FFF4267" modified="2013-06-26" version="1">MADTNDPTSSSSTLEATTNSEPNAQQQSLTQSADNLSPQSQQLANEDPPLDTQLDRDLDAEIDPSTHTVTDSIMVDGMDTTQSSAAPAAGGEPDGMPNIPAVAEPRIPQKKDTSLRGFLGKMDDYAPLIPDAVTDYYLTLAGLPPPPETDRRLARLLALSTQKFIADIAADAYQYSRIRSTNTTSNNPMTGLGGAAGFGMNLPQGGEGEGGGKGKKDAGKAAPLGGPRAGYGGGGGAGGQGRTVLTMEDLGMAVGEYGVNVKRGEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGM8</accession>
    <name>N1PGM8_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_73625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGM8"/>
    <dbReference type="HOGENOM" id="CLU_1517828_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="177" mass="19639" checksum="AAADE33FB0E3DFCB" modified="2013-06-26" version="1">MPHFPSTLSARSVTVQLQLHFYGSITTPKVRGALGSTQLFTSWIVFGSFAAQFSVSSATVKLLFRPRNPLDEPRGLNYGFLRRAHRLKRTRFATVLDHEALYVVGRSVYDKQPSSVLFAGMAQTSSSAGRDRCSYDESPPIFAFRKLQSTQLYFIRTLAAQVALLQLSVSVRGSNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGV0</accession>
    <name>N1PGV0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_55874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGV0"/>
    <dbReference type="STRING" id="675120.N1PGV0"/>
    <dbReference type="eggNOG" id="ENOG502RAM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036632_4_0_1"/>
    <dbReference type="OMA" id="TEVAMHF"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="40"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME40750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="380" mass="41603" checksum="6F3BE9433D3E22A5" modified="2013-06-26" version="1">MADTEGEKWSTAITADNRGPLVTITVGLMLVAMFLFLGFRLTIRWPWPKLIGYDDLATMLGSLFAFGQSLAVFIAIDRGLGQHLDTLDAKKARDATNAIYASDVLSVVALTGSKLAVSLLLMRLSTYKRHINAARVITAVICVWGLIATVITALEIKRARADVRSAWIGLGALSIVLEVALFVLPIFLVWNLKMRLSAKITVVVGFAFRIPASALALARVLAVAKMLSAEEEIGFIDYTWDYINPTIFTTIEMHYSLMAATIPCMHLFLRQFSTGYLGTTNDQLHGTMIGSQNDQTDSYALSSIRSKNRKTAKSRRGGAVRQFSHSEAVSRALYQVDAAVTTISASRDRAGSVVSDGSEKIMVRHTVDVKWSESEECSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>N1PGY2</accession>
    <name>N1PGY2_DOTSN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_82193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446543">
        <property type="protein sequence ID" value="EME40571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PGY2"/>
    <dbReference type="HOGENOM" id="CLU_852650_0_0_1"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME40571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <sequence length="326" mass="36051" checksum="158A259D1209D40D" modified="2013-06-26" version="1">MSVSIPQYTSCIADVIGVVGRGDALARSTAIHHVAQVFSSEVLVTTPIGRPMLSESDGPSQGVVPPQVADGRVELVAHNGIGKPSLVGECFAGLASWTGAQTCDFHLAHTSRDQSTKSHQSRPLVARQDNSSLFVVQRDSTPHPSRHISAALHEVGTGSTPRTASNLAPNHKCHIFRDDERELDRRDSADCCGLRSTADVLRRRGQTRHVRLRPPLRRRDWQRVIKNRRSMWRHEASAVSVRRLHAKPRIRHSKDVDSDRGDNMVIDRPRTPAIPYQAFQDSPRTVPQAPSQSTVIGPKPKRAKVKKCDKPESSRSNFPRPGEPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>N1PI11</accession>
    <name>N1PI11_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DOTSEDRAFT_73974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PI11"/>
    <dbReference type="STRING" id="675120.N1PI11"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012334_0_2_1"/>
    <dbReference type="OMA" id="SSYWTEH"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EME41754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44788" checksum="B930E6C34E50D444" modified="2013-06-26" version="1">MSEEGAAVPAGQKSSWGSFIKQLASFNGDLSTMTAPAWIVSDKSLTEFSAYWAEMPSLLVAPAKEKDPEKRMVLVLKWFLSTLKQQYASRNEKLGSEKKPLNPFLGELFLGKWEDQAGETRLVSEQVSHHPPTTAYSIWNNQHGVRLQGYNAQKASFGTTINVRQVGHAIYHIDQFNEDYIITLPGLHIEGLIKGSPFVELNKSSYIVSSSGYAARIEYSGAGWVSGKKNSLSAVIYPHGKEKSKSSVLYKAKGSWTDSFTIEDSHGKVVENYDAKKEPRTELQVANLKDQDPLETRRAWKKVADAIAKSDMNLVSVEKTKIEEHQRALRKNEKEAGKDWNRTFFSQAKSLPIFEKLIKEVPSGSLEQEQTGGIWVFDQEKAKNAKPPFSQLSAEWKQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>N1PIA6</accession>
    <name>N1PIA6_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DOTSEDRAFT_99368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446542">
        <property type="protein sequence ID" value="EME41859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PIA6"/>
    <dbReference type="STRING" id="675120.N1PIA6"/>
    <dbReference type="HOGENOM" id="CLU_173712_0_0_1"/>
    <dbReference type="OMA" id="QHLSQIW"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EME41859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9551" checksum="6D73F4EF664DD076" modified="2013-06-26" version="1" fragment="single">ESESATTQYLRTHTTIPVSEVYFTNLNPNHVVGSAFTLMEKLPGQHLSQIWDSLSLRHKFEVLKQITGLLVQLSQLRFDEIGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJ35</accession>
    <name>N1PJ35_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DOTSEDRAFT_73029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-Elsalam K.A."/>
                <person name="Aerts A.L."/>
                <person name="Bahkali A.H."/>
                <person name="Beenen H.G."/>
                <person name="Chettri P."/>
                <person name="Cox M.P."/>
                <person name="Datema E."/>
                <person name="de Vries R.P."/>
                <person name="Dhillon B."/>
                <person name="Ganley A.R."/>
                <person name="Griffiths S.A."/>
                <person name="Guo Y."/>
                <person name="Hamelin R.C."/>
                <person name="Henrissat B."/>
                <person name="Kabir M.S."/>
                <person name="Jashni M.K."/>
                <person name="Kema G."/>
                <person name="Klaubauf S."/>
                <person name="Lapidus A."/>
                <person name="Levasseur A."/>
                <person name="Lindquist E."/>
                <person name="Mehrabi R."/>
                <person name="Ohm R.A."/>
                <person name="Owen T.J."/>
                <person name="Salamov A."/>
                <person name="Schwelm A."/>
                <person name="Schijlen E."/>
                <person name="Sun H."/>
                <person name="van den Burg H.A."/>
                <person name="van Ham R.C.H.J."/>
                <person name="Zhang S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
                <person name="Collemare J."/>
                <person name="Bradshaw R.E."/>
            </authorList>
            <dbReference type="PubMed" id="23209441"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1003088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="PLoS Pathog." volume="8" first="E1003037" last="E1003037">
            <title>Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.</title>
            <authorList>
                <person name="Ohm R.A."/>
                <person name="Feau N."/>
                <person name="Henrissat B."/>
                <person name="Schoch C.L."/>
                <person name="Horwitz B.A."/>
                <person name="Barry K.W."/>
                <person name="Condon B.J."/>
                <person name="Copeland A.C."/>
                <person name="Dhillon B."/>
                <person name="Glaser F."/>
                <person name="Hesse C.N."/>
                <person name="Kosti I."/>
                <person name="LaButti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Salamov A.A."/>
                <person name="Bradshaw R.E."/>
                <person name="Ciuffetti L."/>
                <person name="Hamelin R.C."/>
                <person name="Kema G.H.J."/>
                <person name="Lawrence C."/>
                <person name="Scott J.A."/>
                <person name="Spatafora J.W."/>
                <person name="Turgeon B.G."/>
                <person name="de Wit P.J.G.M."/>
                <person name="Zhong S."/>
                <person name="Goodwin S.B."/>
                <person name="Grigoriev I.V."/>
            </authorList>
            <dbReference type="PubMed" id="23236275"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1003037"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NZE10 / CBS 128990</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB446541">
        <property type="protein sequence ID" value="EME42124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="N1PJ35"/>
    <dbReference type="STRING" id="675120.N1PJ35"/>
    <dbReference type="HOGENOM" id="CLU_568610_0_0_1"/>
    <dbReference type="OrthoDB" id="10534108at2759"/>
    <dbReference type="Proteomes" id="UP000016933">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EME42124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="54019" checksum="4EC0A9CE6CA52547" modified="2013-06-26" version="1">MFRWYRSSKCCLAYLADVGSLSDGEDVVMEAFRKSVWFTRAWTLQELLAPTTVLFVNREWEIIGHKGRIRKGMGNLVRSTNDLTDQIAEITGIRRPVLLDFSMSKNIPFEEKQGWVMHRQTTRQEDKAYCLLGIFNISMPLIYGEGRKSFKRFLREVEEKERDTARKKQKKQKKMERKIRAQMDEAQEAERAPLTPILESPLVEVKGPRPIDRAIPLPSIPIPGPCTPYELVTTKTQRFSAIASALRHLWIAANSREQAIFAVASILDERGYAVPGDTIHEALSDMELVSSLAQVAYSGMVAAGWAPEDAVRHIESVCEQEGHPPEMAAAIAQEYMIYDAAVVDRGGFPYIPPSESFVSEESSLELKARRATVERHENDPSEQTLRDLQIEREDCVVKPASCTGLLPSLNLQKIAQSNEIQGAHHEADIEELDVDTTVLDAPRLSGQGITRTSETTSKDQGFVLMDTIPFDHFAAMHLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>N1PJF0</accession>
    <name>N1PJF0_DOTSN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DOTSEDRAFT_73153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dothistroma septosporum (strain NZE10 / CBS 128990)</name>
        <name type="common">Red band needle blight fungus</name>
        <name type="synonym">Mycosphaerella pini</name>
        <dbReference type="NCBI Taxonomy" id="675120"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Dothideomycetidae</taxon>
            <taxon>Mycosphaerellales</taxon>
            <taxon>Mycosphaerellaceae</taxon>
            <taxon>Dothistroma</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1003088" last="E1003088">
            <title>The genomes of the fungal plant pathogens Cladosporium fulvum and Dothistroma septosporum reveal adaptation to different hosts and lifestyles but also signatures of common ancestry.</title>
            <authorList>
                <person name="de Wit P.J.G.M."/>
                <person name="van der Burgt A."/>
                <person name="Oekmen B."/>
                <person name="Stergiopoulos I."/>
                <person name="Abd-